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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Current Management of Diaphyseal Long Bone Defects-A Multidisciplinary and International Perspective | The treatment of defects of the long bones remains one of the biggest challenges in trauma and orthopedic surgery. The treatment path is usually very wearing for the patient, the patient's environment and the treating physician. The clinical or regional circumstances, the defect etiology and the patient ' s condition and mental status define the treatment path chosen by the treating surgeon. Depending on the patient ' s demands, the bony reconstruction has to be taken into consideration at a defect size of 2-3 cm, especially in the lower limbs. Below this defect size, acute shortening or bone grafting is usually preferred. A thorough assessment of the patient ' s condition including comorbidities in a multidisciplinary manner and her or his personal demands must be taken into consideration. Several techniques are available to restore continuity of the long bone. In general, these techniques can be divided into repair techniques and reconstructive techniques. The aim of the repair techniques is anatomical restoration of the bone with differentiation of the cortex and marrow. Currently, classic, hybrid or all-internal distraction devices are technical options. However, they are all based on distraction osteogenesis. Reconstructive techniques restore long-bone continuity by replacing the defect zone with autologous bone, e.g., with a vascularized bone graft or with the technique described by Masquelet. Allografts for defect reconstruction in long bones might also be described as possible options. Due to limited access to allografts in many countries and the authors' opinion that allografts result in poorer outcomes, this review focuses on autologous techniques and gives an internationally aligned overview of the current concepts in repair or reconstruction techniques of segmental long-bone defects. | Rosslenbroich, Steffen Bernd; Oh, Chang-Wug; Kern, Thomas; Mukhopadhaya, John; Raschke, Michael Johannes; Kneser, Ulrich; Krettek, Christian | Univ Hosp Muenster, Dept Trauma Hand & Reconstruct Surg, D-48149 Munster, Germany; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthoped Surg, Daegu 41944, South Korea; BG Unfallklin Murnau, Dept Trauma Surg Murnau, D-82418 Murnau, Germany; Paras HMRI Hosp, Orthoped & Trauma Dept, Patna 800014, Bihar, India; Univ Heidelberg Ludwigshafen, BG Trauma Ctr Ludwigshafen, Dept Plast Surg, D-67059 Heidelberg, Germany; Hannover Med Sch, Trauma Dept Hannover, D-30625 Hannover, Germany | ; Oh, Chang-Wug/AAO-4602-2021; Rosslenbroich, Steffen/AIB-3974-2022 | 23669360200; 22135834200; 56392612000; 57205071975; 7004520056; 26643400800; 35076106000 | steffen.rosslenbroich@ukmuenster.de;cwoh@knu.ac.kr;thomas.kern@bgu-murnau.de;mukhoj@gmail.com;michael.raschke@ukmuenster.de;ulrich.kneser@bgu-ludwigshafen.de;krettek.christian@mh-hannover.de; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 19 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.24 | 2025-06-25 | 2 | 2 | bone defect; callus distraction; all-internal distraction; Ilizarov | INDUCED MEMBRANE TECHNIQUE; EXTERNAL FIXATOR; INTRAMEDULLARY NAIL; SEGMENTAL TRANSPORT; GROWTH-FACTORS; ILIAC CREST; RECONSTRUCTION; PLATE; ASPIRATE; MODULE | all-internal distraction; bone defect; callus distraction; Ilizarov | antibiotic bone cement; gentamicin bone cement; bone allograft; bone defect; bone development; bone graft; bone remodeling; callus distraction; diaphysis; distraction osteogenesis; human; long bone; outcome assessment; radius fracture; Review; ulna fracture | English | 2023 | 2023-10 | 10.3390/jcm12196283 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Current Status of Q Fever and the Challenge of Outbreak Preparedness in Korea: One Health Approach to Zoonoses | Human Q fever, a zoonosis caused by Coxiella burnetii, presents with diverse clinical manifestations ranging from mild self-limited febrile illnesses to life-threatening complications such as endocarditis or vascular infection. Although acute Q fever is a benign illness with a low mortality rate, a large-scale outbreak of Q fever in the Netherlands led to concerns about the possibility of blood transfusion-related transmission or obstetric complications in pregnant women. Furthermore, a small minority (< 5%) of patients with asymptomatic or symptomatic infection progress to chronic Q fever. Chronic Q fever is fatal in 5-50% of patients if left untreated. In South Korea, Q fever in humans was designated as a notifiable infectious disease in 2006, and the number of Q fever cases has increased sharply since 2015. Nonetheless, it is still considered a neglected and under-recognized infectious disease. In this review, recent trends of human and animal Q fever in South Korea, and public health concerns regarding Q fever outbreaks are reviewed, and we consider how a One Health approach could be applied as a preventive measure to prepare for zoonotic Q fever outbreaks. | Cho, Yun Sang; Park, Ji-Hyuk; Kim, Jong Wan; Lee, Jin-Ju; Youn, So Youn; Byeon, Hyeon Seop; Jeong, Hye Won; Kim, Dong-Min; Yu, Shi Nae; Yoon, Jang Won; Kwak, Dongmi; Yoo, Han Sang; Lee, Ji-Yeon; Kwon, Jeong-Ran; Hwang, Kyung-Won; Heo, Jung Yeon | Anim & Plant Quarantine Agcy, Dept Anim & Plant Hlth Res, Bacterial Dis Div, Lab Parasit & Honeybee Dis, Gimcheon, South Korea; Dongguk Univ, Coll Med, Dept Prevent Med, Gyeongju, South Korea; Anim & Plant Quarantine Agcy, Dept Anim & Plant Hlth Res, Res Planning Div, Gimcheon, South Korea; Anim & Plant Quarantine Agcy, World Org Anim Hlth WOAH Reference Lab Brucellosis, Bacterial Dis Div, Dept Anim & Plant Hlth Res, Gimcheon, South Korea; Chungcheongbuk Do Inst Vet Serv & Res, Cheongju, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju, South Korea; Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; Chosun Univ, Dept Internal Med, Div Infect Dis, Coll Med, Gwangju, South Korea; Soonchunhyang Univ, Cheonan Hosp, Dept Internal Med, Div Infect Dis, Cheonan, South Korea; Kangwon Natl Univ, Coll Vet Med, Chunchon, Gangwon, South Korea; Kangwon Natl Univ, Inst Vet Sci, Chunchon, Gangwon, South Korea; Kyungpook Natl Univ, Coll Vet Med, Div Vet Parasitol, Daegu, South Korea; Seoul Natl Univ, Coll Vet Med, Dept Infect Dis, Seoul, South Korea; Korea Dis Control & Prevent Agcy, Bur Infect Dis Policy, Div Zoonot & Vector Borne Dis Control, Cheongju, South Korea; Ajou Univ, Dept Infect Dis, Sch Med, Suwon, South Korea; Ajou Univ, Dept Infect Dis, Sch Med, 164 World Cup Ro, Suwon 16499, South Korea | ; Jeong, Hye/AET-1982-2022; kim, dongmin/MEO-8165-2025; Cho, Yun Sang/ACA-6165-2022 | 16066666200; 55343358200; 56313003400; 37960993400; 57190743135; 56606934900; 13103042700; 39861468000; 57203755478; 7403587255; 7007148758; 56507863000; 58336425000; 57188563581; 58336425100; 24587525000 | jyheomd@ajou.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 24 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 1.02 | 2025-06-25 | 4 | 4 | QFever; Coxiella burnetii; Zoonoses; One Health | COXIELLA-BURNETII INFECTIONS; UNITED-STATES; DIAGNOSIS; NETHERLANDS; BRUCELLOSIS; PNEUMONIA; RISK; TRANSMISSION; ENDOCARDITIS; VACCINATION | Coxiella burnetii; One Health; Q Fever; Zoonoses | Animals; Communicable Diseases; Disease Outbreaks; Female; Humans; One Health; Pregnancy; Q Fever; Republic of Korea; Zoonoses; animal; communicable disease; epidemic; female; human; One Health; pregnancy; Q fever; South Korea; zoonosis | English | 2023 | 2023-06-19 | 10.3346/jkms.2023.38.e197 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Data-similarity-based IoT node selection for UAV trajectory optimization | Data collected from densely deployed IoT sensor nodes via UAVs may incur remarkable redundancy, unnecessarily wasting the UAV power. This paper introduces a framework of UAV trajectory planning for optimizing energy efficiency via data-similarity-based node selection while maintaining sufficient information integrity out of the refined data. The proposed framework consists of three phases, namely data similarity determination, redundant nodes removal, and UAV trajectory planning. In particular, we propose a sliding-window dynamic time warping (SDTW) algorithm to quantify the data similarity between nodes. Then a hybrid genetic ant colony algorithm (HGACA) is introduced for the redundant node removal, where data similarity and UAV energy consumption are jointly considered. Finally, we formulate the trajectory planning problem as a three-stage integer linear programming (ILP) model, which clusters the nodes with minimal overlap and finds the shortest UAV cruising path that traverses each cluster head once and only once. The simulation result demonstrates that the proposed framework outperforms all the considered counterparts under various threshold values of data similarity in terms of execution time and power consumption while maintaining information integrity. | Mei, Haoran; Khan, Muhammad Fawad; Peng, Limei; Tak, Byungchul; Lee, Jiyeon; Ho, Pin-Han | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea; Univ Waterloo, Dept Elect & Comp Engn, Waterloo, ON, Canada | Khan, Muhammad Fawad/KZU-3885-2024; Mei, Haoran/HKF-6510-2023 | 57208655106; 58295476600; 7201574271; 6506911621; 58377757200; 7402211578 | auroraplm@knu.ac.kr; | COMPUTERS & ELECTRICAL ENGINEERING | COMPUT ELECTR ENG | 0045-7906 | 1879-0755 | 112 | SCIE | COMPUTER SCIENCE, HARDWARE & ARCHITECTURE;COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;ENGINEERING, ELECTRICAL & ELECTRONIC | 2023 | 4 | 17.8 | 0.38 | 2025-06-25 | 3 | 3 | IoT; UAV; Data collection; ILP; Clustering | DATA AGGREGATION | Clustering; Data collection; ILP; IoT; UAV | Ant colony optimization; Energy efficiency; Energy utilization; Genetic algorithms; Integer programming; Internet of things; Sensor nodes; Trajectories; Clusterings; Data collection; Data-similarity; Information integrity; Integer Linear Programming; IoT; Node selection; Redundant nodes; Trajectory optimization; Trajectory Planning; Unmanned aerial vehicles (UAV) | English | 2023 | 2023-12 | 10.1016/j.compeleceng.2023.108994 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | De Novo Crescentic Glomerulonephritis Following COVID-19 Infection: A Pediatric Case Report | As the global coronavirus disease 2019 (COVID-19) pandemic continues to sweep across the globe, reports of kidney involvement in adult patients infected with COVID-19 have been documented, and recently, cases in the pediatric population have also been reported. This report highlights the case of an 11-year-old boy who developed acute kidney injury presenting as gross hematuria, proteinuria, and hypertension immediately after a COVID-19 infection. A renal biopsy allowed us to diagnose the patient with post-COVID-19 infection -associated de novo crescentic immune-mediated glomerulonephritis. Oral prednisolone and cyclophosphamide treatments were initiated after methylprednisolone pulse therapy administration. Currently, the patient is receiving medical treatment for five weeks, and his renal function is gradually recovering. Previous studies have suggested that, although quite rare, a variety of kidney complications can occur after COVID-19 infection or vaccination, and it is recommended to monitor renal function through evaluation. Herein, we report a pediatric case of post-COVID-19 infection-associated de novo crescentic immune-mediated glomerulonephritis consistent with rapidly progressive glomerulonephritis. | Eun, Jung Kwan; Park, Min Ji; Kim, Mee-seon; Han, Man Hoon; Kim, Yong-Jin; Baek, Hee Sun; Cho, Min Hyun | Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pediat, 130 Dongdeok-ro, Daegu 41944, South Korea | ; Kim, Yong-Jin/J-2745-2012 | 58159064100; 57425372600; 56123006700; 57194067936; 56150365500; 56689379700; 7401727726 | chomh@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 12 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.77 | 2025-06-25 | 3 | 3 | De Novo; Crescentic Glomerulonephritis; COVID-19; Pediatric | MINIMAL CHANGE DISEASE | COVID-19; Crescentic Glomerulonephritis; De Novo; Pediatric | Acute Kidney Injury; Adult; Child; COVID-19; Glomerulonephritis; Humans; Kidney; Male; Nephritis; acute kidney failure; adult; case report; child; complication; glomerulonephritis; human; kidney; male; nephritis; pathology | English | 2023 | 2023-03-27 | 10.3346/jkms.2023.38.e89 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Deep Neural Network-Based Automatic Dicentric Chromosome Detection Using a Model Pretrained on Common Objects | Dicentric chromosome assay (DCA) is one of the cytogenetic dosimetry methods where the absorbed dose is estimated by counting the number of dicentric chromosomes, which is a major radiation-induced change in DNA. However, DCA is a time-consuming task and requires technical expertise. In this study, a neural network was applied for automating the DCA. We used YOLOv5, a one-stage detection algorithm, to mitigate these limitations by automating the estimation of the number of dicentric chromosomes in chromosome metaphase images. YOLOv5 was pretrained on common object datasets. For training, 887 augmented chromosome images were used. We evaluated the model using validation and test datasets with 380 and 300 images, respectively. With pretrained parameters, the trained model detected chromosomes in the images with a maximum F1 score of 0.94 and a mean average precision (mAP) of 0.961. Conversely, when the model was randomly initialized, the training performance decreased, with a maximum F1 score and mAP of 0.82 and 0.873%, respectively. These results confirm that the model could effectively detect dicentric chromosomes in an image. Consequently, automatic DCA is expected to be conducted based on deep learning for object detection, requiring a relatively small amount of chromosome data for training using the pretrained network. | Kim, Kangsan; Kim, Kwang Seok; Jang, Won Il; Jang, Seongjae; Hwang, Gil Tae; Woo, Sang-Keun | Korea Inst Radiol & Med Sci, Div Appl RI, Seoul 01812, South Korea; Korea Inst Radiol & Med Sci, Dept Radiat Oncol, Seoul 01812, South Korea; Korea Inst Radiol & Med Sci, Natl Radiat Emergency Med Ctr, Seoul 01812, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea | Jang, Seongjae/AAV-5628-2021; Hwang, Gil Tae/L-6502-2017 | 57223962028; 50461711800; 55897965000; 15750593000; 7202676087; 12752961800 | krmount@kirams.re.kr;giltae@knu.ac.kr;skwoo@kirams.re.kr; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 13 | 20 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.76 | 2025-06-25 | 4 | 4 | dicentric chromosome assay; cytogenetic dosimetry; chromosome metaphases image; object detection; you only look once; deep learning; transfer learning | STRAND BREAK REPAIR; INDUCED DNA-DAMAGE; BIOLOGICAL DOSIMETRY; RADIATION; MECHANISMS | chromosome metaphases image; cytogenetic dosimetry; deep learning; dicentric chromosome assay; object detection; transfer learning; you only look once | Article; artificial neural network; controlled study; convolutional neural network; deep neural network; dicentric chromosome; metaphase chromosome | English | 2023 | 2023-10 | 10.3390/diagnostics13203191 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Developing an Attention Assessment Tool for Individuals With Autism Spectrum Disorder Using Timbre, Rhythm, and Pitch | Background: Music is regarded as a beneficial tool for assessing the clinical symptoms and communication skills in individuals with autism spectrum disorder (ASD) or autism. The present study developed a music-based attention test (MAT) for individuals with autism using music parameters and the algorithm of the comprehensive attention test (CAT).Methods: We recruited 51 autistic individuals and 50 neurotypical individuals to participate in the CAT, MAT, and social intelligence tests. The reliability and validity of the MAT were assessed using exploratory factor analysis, concurrent validity, and criterion-related validity.Results: The MAT had sound internal consistency (high Cronbach's & alpha; = 0.948). In addition, the MAT had suitable concurrent validity in the correlation between CAT and MAT, as well as good criterion validity when attention was measured using the MAT and was compared between autistic individuals and neurotypical individuals. Attention evaluated using the MAT was associated with the social quotient in individuals with autism.Conclusions: The MAT could be a relevant tool for gauging attention in individuals with ASD. Furthermore, attention determined using the MAT may be correlated with social quotient in autistic individuals. Future studies should consider that using music in the field of attention could improve the social quotient of individuals with autism. | Lee, Jin Hyung; Hwang, Hyunchan; Yun, Juri; Kim, Hee Jun; Yoo, Seo-Koo; Chung, Un Sun; Han, Doug Hyun | Chung Ang Univ Hosp, Dept Psychiat, Seoul, South Korea; Ewha Womans Univ, Dept Mus Therapy, Seoul, South Korea; Chung Ang Univ Hosp, Dept Oncol, Seoul, South Korea; Soongsil Univ, Sch Social Welf, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu, South Korea; Chung Ang Univ Hosp, Dept Psychiat, 102 Heukseok Ro, Seoul 06973, South Korea | Kim, Jee/J-5441-2012 | 57145328700; 57202022375; 57219801809; 57203630724; 56567186100; 24477437300; 8774251600 | hduk70@gmail.com; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 29 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0 | 2025-06-25 | 0 | 0 | Music Attention Test; Comprehensive Attention Test; Autism Spectrum Disorder; Social Quotient | DEFICIT/HYPERACTIVITY DISORDER; MUSIC-THERAPY; CHILDREN; SKILLS; INTERVENTION | Autism Spectrum Disorder; Comprehensive Attention Test; Music Attention Test; Social Quotient | Algorithms; Autism Spectrum Disorder; Autistic Disorder; Factor Analysis, Statistical; Humans; Reproducibility of Results; algorithm; autism; factor analysis; human; reproducibility | English | 2023 | 2023-07-24 | 10.3346/jkms.2023.38.e228 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Do Concurrent Multiple Infections with High-Risk HPVs Carry a More Malignant Potential than a Single Infection in the Uterine Cervix? | The high-risk human papillomavirus (HR-HPV) has been known as the most important carcinogen in uterine cervical carcinoma. However, there is limited evidence of the malignant potential of these concurrent multiple infections. This study included women who had undergone cervical conization. They underwent an HPV test by cervical swab within 12 months before the surgery. They were divided into two groups: one with a single infection with HR-HPV16 and the other with concurrent multiple infections with HR-HPVs, including genotype 16. Pathologic examination classified cases as CIS+ to assess and compare the malignant potential in both groups, including carcinoma in situ (CIS) and invasive carcinoma. Of the 220 patients infected with HR-HPV16, the single infection group consisted of 120 patients (54.5%), whereas the concurrent multiple infections consisted of 100 (45.5%) patients. The rates of HSIL were significantly higher in the concurrent multiple infection group. However, the odds ratio for CIS+ did not show a significant difference between both groups (1.417, 95% CI = 0.831-2.414, p = 0.200). The malignant potential was not significantly different between concurrent multiple infections with HR-HPVs, including 16, and a single infection with 16 in Korean women. | Lee, Juhun; Lee, Hyun Jung | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Obstet & Gynecol, Daegu 41944, South Korea | 57360628800; 57202930844 | gyjhlee@knu.ac.kr;obgy1019@daum.net; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 19 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.26 | 2025-06-25 | 1 | 1 | human papillomavirus; concurrent multiple HPV infections; cervical premalignancy; malignant potential; risk of carcinogenesis; cervical cancer | HUMAN-PAPILLOMAVIRUS TYPES; CANCER STATISTICS; PREVALENCE; NEOPLASIA; TYPE-16; PROTEIN; WOMEN; DNA; E7 | cervical cancer; cervical premalignancy; concurrent multiple HPV infections; human papillomavirus; malignant potential; risk of carcinogenesis | adult; Article; cancer patient; cancer risk; cancer surgery; carcinogenesis; coinfection; female; genotype; histopathology; human; Human papillomavirus type 16; infection risk; Korean (people); major clinical study; papillomavirus infection; patient selection; precancer; risk assessment; risk factor; uterine cervicitis; uterine cervix carcinoma; uterine cervix carcinoma in situ; uterine cervix conization | English | 2023 | 2023-10 | 10.3390/jcm12196155 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effect of Minimum Bronchial Cuff Volume of Left-Sided Double-Lumen Tube for One-Lung Ventilation on the Change in Bronchial Cuff Pressure during Lateral Positioning in Thoracic Surgery: A Prospective Observational Study | The minimum bronchial cuff volume (BCVmin) of a double-lumen tube (DLT) without air leaks during lung isolation may vary among individuals, and lateral positioning could increase the bronchial cuff pressure (BCP). We investigated the effect of initially established BCVmin (BCVi) on the change in BCP by lateral positioning. Seventy patients who underwent elective lung surgery were recruited and divided into two groups according to the BCVi obtained during anesthetic induction in each patient. Outcome analysis was conducted using data from 39 patients with a BCVi greater than 0 (BCVi > 0 group) and 27 with a BCVi of 0 (BCVi = 0 group). The primary outcome was a change in the value measured in the supine and lateral positions of the initially established BCP (BCPi; BCP at the time of BCVi injection), which was significantly larger in the BCVi > 0 group than in the BCVi = 0 group (1.5 (0.5-6.0) cmH(2)O vs. 0.0 (0.0-1.0) cmH(2)O; p < 0.001). BCVi was related to the left main bronchus (LMB) diameter (Spearman's rho = 0.676, p < 0.001) and the gap between the LMB diameter and the outer diameter of the bronchial cuff (Spearman's rho = 0.553, p < 0.001). Therefore, selecting a DLT size with a bronchial cuff that fits each patient's LMB may be useful in minimizing the change in BCP when performing lateral positioning during thoracic surgery. If the bronchial cuff requires unavoidable initial inflation, it is necessary to be aware that BCP may increase during lateral positioning and to monitor the BCP regularly if possible. | Do, Young-Woo; Kim, Jong-Hae; Kim, Kyungmin; Oh, Jinyoung; Kwak, Kyung-Hwa; Jeon, Younghoon; Byun, Sung-Hye | Kyungpook Natl Univ, Sch Med, Dept Thorac & Cardiovasc Surg, 807 Hoguk Ro, Daegu 41404, South Korea; Daegu Catholic Univ, Sch Med, Dept Anesthesiol & Pain Med, 33 Duryugongwon Ro 17 Gil, Daegu 42472, South Korea; Kyungpook Natl Univ, Sch Med, Dept Anesthesiol & Pain Med, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Anesthesiol & Pain Med, 130 Dongdeok Ro, Daegu 41944, South Korea | Byun, Sung Hye/AEK-1234-2022; Kim, JongHae/HGC-1554-2022 | 57189600352; 57865562800; 57201480192; 57609999900; 22937974700; 21645921000; 56921446300 | stone0311@naver.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 7 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0 | 2025-06-25 | 0 | 0 | double-lumen tube; lateral position; cuff; pressure; thoracic surgery | SIZE; ANATOMY; CT | cuff; double-lumen tube; lateral position; pressure; thoracic surgery | propofol; remifentanil; rocuronium; adult; aged; anesthesia induction; Article; bronchial cuff pressure; bronchial cuff volume; capnometry; computer assisted tomography; controlled study; correlation coefficient; endotracheal intubation; female; human; lung surgery; main bronchus; major clinical study; male; observational study; one lung ventilation; outcome assessment; pilot study; prospective study; supine position; thoracoscopy; thorax surgery; video assisted thoracoscopic surgery | English | 2023 | 2023-04 | 10.3390/jcm12072473 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Electrophysiologic Patterns of Symptomatic Vincristine-Induced Peripheral Neuropathy in Children with Acute Lymphocytic Leukemia | Acute lymphocytic leukemia is one of the most common cancers in children. Multi-drug chemotherapy is used for treatment, and the representative drug is vincristine. Although various side effects may occur due to vincristine, the association with peripheral neuropathy is high compared to that of other drugs. This study focused on children under the age of 18 years of age with ALL who received chemotherapy containing vincristine. We retrospectively analyzed the results of a nerve conduction study and a cumulative dose of vincristine in 30 children diagnosed with peripheral neuropathy. The average cumulative dose until diagnosis of vincristine-induced peripheral neuropathy was 14.99 +/- 1.21 mg/m(2), and motor nerves were predominantly involved. Additionally, a marked decrease in average amplitude was also observed in motor nerves. In addition, when the relationship between the incidence of peripheral neuropathy and the cumulative dose was analyzed through the survival curve, about 50% of children developed peripheral neuropathy at a dose of 15.5 +/- 1.77 mg/m(2). Based on the electrophysiological characteristics of pediatric vincristine-induced peripheral neuropathy, as well as the relationship between the incidence rate and the cumulative dose, it is possible to observe more closely the vincristine-induced peripheral neuropathy occurrence in children with ALL at an appropriate time. | Jeong, Jae-Gyeong; Ahn, Chang-Hwan; Min, Yu-Sun; Kim, Sung Eun; Kim, Ji Yoon; Jung, Tae-Du | Kyungpook Natl Univ Hosp, Dept Rehabil Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Rehabil Med, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Pediat, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu 41944, South Korea | ; KIM, SUNG/ADF-8559-2022 | 57222016696; 58076572400; 48061349800; 57224168759; 57205408095; 36622364500 | phojyk@knu.ac.kr;teeed0522@hanmail.net; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.77 | 2025-06-25 | 2 | 3 | acute lymphocytic leukemia; vincristine-induced peripheral neuropathy; chemotherapy-induced peripheral neuropathy; nerve conduction study; pediatrics | ACUTE LYMPHOBLASTIC-LEUKEMIA; NERVE-CONDUCTION; VINCA ALKALOIDS; CANCER; NEUROTOXICITY; VINBLASTINE; THERAPY | acute lymphocytic leukemia; chemotherapy-induced peripheral neuropathy; nerve conduction study; pediatrics; vincristine-induced peripheral neuropathy | asparaginase; cyclophosphamide; cytarabine; daunorubicin; dexamethasone; doxorubicin; mercaptopurine; methotrexate; prednisone; tioguanine; vincristine; acute lymphoblastic leukemia; adolescent; adult; Article; cancer chemotherapy; cancer survival; chemotherapy-induced peripheral neuropathy; child; clinical article; controlled study; electrophysiology; female; human; incidence; male; median nerve; motor nerve; nerve conduction; peroneus nerve; retrospective study; survival rate; tibial nerve; ulnar nerve | English | 2023 | 2023-01 | 10.3390/jcm12020686 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Emotional and Behavioral Correlates of Exposure to Electronic Media in School-Aged Children: A Prospective Study | Background: Exposure to electronic media is increasing from early childhood. This study aimed to examine the association between screen time and behavioral outcomes in school aged children with a prospective birth-cohort.Methods: We examined the association between screen time and behavioral outcomes in school-aged children with a Korean birth-cohort study. Participants were 2,150 children, recruited during their fetal period, assessed annually for developmental outcomes. Media exposure was assessed at T4 (3.2 y/o), T8 (7.3 y/o), and T10 (9.4 y/o). After exclusions for missing data, 1,368 children were categorized into four groups (Low-Low, Low-High, High Low, and High-High) based on average daily media time in early childhood and during schooldays, respectively. Children's temperament was assessed from T1 (0.5 y/o) to T4. Emotional and behavioral outcomes were assessed using the Child Behavior Checklist (DSMoriented subscales) at T8 and T10.Results: We found that early-years temperament was generally similar between the media time groups: they only differed significantly on Activity at T1 and Emotionality at T2 (1.2 y/o). However, compared to the Low-Low group, the Low-High group had significantly higher odds of high-risk scores for Conduct Problems (increased odds ratios [ORs] of 1.82 at T8 and 1.83 at T10) and Anxiety Problems (increased ORs of 1.60 at T8 and 1.82 at T10). Self-rated self-esteem and overall happiness at T10 also significantly differed among the four groups.Conclusion: Our findings suggest the negative impacts of media exposure on the emotional and behavioral development of school-aged children, which substantiates the guidelines that restrict media exposure during childhood. | Kim, Kyoung Min; Chung, Un Sun | Dankook Univ, Coll Med, Dept Psychiat, Cheonan, South Korea; Dankook Univ Hosp, Dept Psychiat, Cheonan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 57202116799; 24477437300 | unsunchung@gmail.com; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 36 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.51 | 2025-06-25 | 3 | 3 | Screen Media; Behavior; Emotion; Childbirth Cohort; School-Aged Children | SEDENTARY BEHAVIOR; TELEVISION; ASSOCIATION; ADOLESCENTS; DISORDERS; IMITATION; YOUNGER; ANXIETY; HEALTH | Behavior; Childbirth Cohort; Emotion; School-Aged Children; Screen Media | Anxiety; Child; Child, Preschool; Cohort Studies; Electronics; Emotions; Humans; Prospective Studies; anxiety; child; cohort analysis; emotion; human; preschool child; prospective study | English | 2023 | 2023-09-11 | 10.3346/jkms.2023.38.e283 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Epigenetic Regulation of the Expression of T Cell Stimulatory and Inhibitory Factors by Histone H3 Lysine Modification Enzymes and Its Prognostic Roles in Glioblastoma | Background: This study aimed to identify the specific T cell co-stimulatory and co-inhibitory factors that play prognostic roles in patients with glioblastoma. Additionally, the unique histone H3 modification enzymes that regulate the expression levels of these specific co stimulatory and co-inhibitory factors were investigated.Methods: The medical records of 84 patients newly diagnosed with glioblastoma at our institution from January 2006 to December 2020 were retrospectively reviewed. Immunohistochemical (IHC) staining for T cell co-stimulatory factors (CD27, CD28, CD137, OX40, and ICOS), T cell co-inhibitory factors (CTLA4, PD1, PD-L1, TIM3, and CD200R), and histone H3 lysine modification enzymes (MLL4, RIZ, EZH1, NSD2, KDM5c, JMJD1a, UTX, and JMJD5) was performed on archived paraffin-embedded tissues obtained by biopsy or resection. Quantitative real time-polymerase chain reaction (qRT-PCR) was performed for specific factors, which demonstrated causal relationships, in order to validate the findings of the IHC examinations.Results: The mean follow-up duration was 27.5 months (range, 4.1-43.5 months). During this period, 76 patients (90.5%) died, and the mean OS was 19.4 months (95% confidence interval, 16.3-20.9 months). Linear positive correlations were observed between the expression levels of CD28 and JMJD1a (R2 linear = 0.982) and those of CD137 and UTX (R2 linear = 1.528). Alternatively, significant negative correlations were observed between the expression levels of CTLA4 and RIZ (R2 linear = -1.746) and those of PD-L1 and EZH1 (R2 linear = -2.118); these relationships were confirmed by qRT-PCR. In the multivariate analysis, increased expression levels of CD28 (P = 0.042), and CD137 (P = 0.009), and decreased expression levels of CTLA4 (P = 0.003), PD-L1 (P = 0.020), and EZH1 (P = 0.040) were significantly associated with longer survival.Conclusion: These findings suggest that the expression of certain T cell co-stimulatory factors, such as CD28 and CD 137, and co-inhibitory factors, such as CTLA4 and PD-L1 are associated with prognosis of glioblastoma patients. | Lee, Sang Hyuk; Kim, Seung Hwan; Nam, Taek Min; Jang, Ji Hwan; Kim, Kyu Hong; Lee, Young-Sam; Kim, Minseok S.; Kim, Mee-Seon; Jin, Sung Yup; Lee, Moonok; Lee, Sung-Hun; Kim, Young Zoon | Sungkyunkwan Univ, Samsung Changwon Hosp, Sch Med, Dept Neurosurg, 158 Paryong Ro, Chang Won 51353, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Dept New Biol, Daegu 42988, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Well Aging Res Ctr, Div Biotechnol, Daegu, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Translat Respons Med Ctr, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Dent, Dept Pathol, Daegu, South Korea; Sungkyunkwan Univ, Samsung Changwon Hosp, Dept Anesthesiol & Pain Med, Sch Med, Chang Won, South Korea; Clinomics Inc, Canc Res Inst, Suwon, South Korea | ; Kim, Seunghyun/AAA-3402-2022; Nam, Taek Min/JRX-4545-2023; Kim, Minseok/AAJ-4797-2020 | 57241362600; 57218140329; 56927761300; 37665123400; 27867788800; 56328278900; 57191998332; 56123006700; 57223172442; 57211403848; 57203597138; 55574096600 | yzkim@skku.edu; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 33 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.26 | 2025-06-25 | 1 | 1 | Sang Hyuk Lee ; Glioblastoma; Epigenome; Histone Modification; T Cell; Immunology; Oncology | TUMOR-INFILTRATING LYMPHOCYTES; CENTRAL-NERVOUS-SYSTEM; HODGKIN LYMPHOMA; DNA METHYLATION; PD-L1; BLOCKADE; SURVIVAL; NIVOLUMAB; THERAPY; AMPLIFICATION | Epigenome; Glioblastoma; Histone Modification; Immunology; Oncology; T Cell | B7-H1 Antigen; CD28 Antigens; CTLA-4 Antigen; Epigenesis, Genetic; Glioblastoma; Histones; Humans; Lysine; Prognosis; Retrospective Studies; T-Lymphocytes; CD28 antigen; cytotoxic T lymphocyte antigen 4; histone; lysine; programmed death 1 ligand 1; genetic epigenesis; genetics; glioblastoma; human; prognosis; retrospective study; T lymphocyte | English | 2023 | 2023-08-21 | 10.3346/jkms.2023.38.e258 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Correction | Establishment of a Nationwide Korean Imaging Cohort of Coronavirus Disease 2019 (vol 35, e413, 2019) | Yoon, Soon Ho; Ham, Soo-Youn; Nam, Bo Da; Chae, Kum Ju; Lee, Dabee; Yoo, Jin Young; Bak, So Hyeon; Kim, Jin Young; Kim, Jin Hwan; Kim, Ki Beom; Jung, Jung Im; Lim, Jae-Kwang; Lee, Jong Eun; Chung, Myung Jin; Lee, Young Kyung; Kim, Young Seon; Jo, Ji Eun; Lee, Sang Min; Kwon, Woocheol; Park, Chang Min; Kim, Yun-Hyeon; Jeong, Yeon Joo | Seoul Natl Univ Hosp, Dept Radiol, Seoul Natl Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Radiol, Seoul, South Korea; Soonchunhyang Univ, Seoul Hosp, Coll Med, Dept Radiol, Seoul, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Dept Radiol,Res Inst Clin Med, Biomed Res Inst, Jeonju, South Korea; Dankook Univ Hosp, Dept Radiol, Cheonan, South Korea; Chungbuk Natl Univ Hosp, Dept Radiol, Cheongju, South Korea; Kangwon Natl Univ, Kangwon Natl Univ Hosp, Sch Med, Dept Radiol, Chunchon, South Korea; Keimyung Univ, Sch Med, Dept Radiol, Dongsan Hosp, Daegu, South Korea; Chungnam Natl Univ Hosp, Coll Med, Dept Radiol, Daejeon, South Korea; Daegu Fatima Hosp, Dept Radiol, Daegu, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Radiol, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Radiol, Daegu, South Korea; Chonnam Natl Univ Hosp, Dept Radiol, Gwangju, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiol, Seoul, South Korea; Seoul Med Ctr, Dept Radiol, Seoul, South Korea; Yeungnam Univ, Yeungnam Univ Hosp, Dept Radiol, Coll Med, Daegu, South Korea; Busan Med Ctr, Dept Radiol, Busan, South Korea; Univ Ulsan, Asan Med Ctr, Dept Radiol, Coll Med, Seoul, South Korea; Univ Ulsan, Res Inst Radiol, Asan Med Ctr, Coll Med, Seoul, South Korea; Ewha Womans Univ, Dept Radiol, Seoul Hosp, Seoul, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Sch Med, Dept Radiol, 179 Gudeok Ro, Busan 49241, South Korea; Biomed Res Inst, 179 Gudeok Ro, Busan 49241, South Korea | ; Yoo, Jin/AAG-6414-2019; Lee, Jung-Seok/L-6826-2019; Nam, Boda/MSX-2031-2025; Kim, Juhee/KFS-3069-2024; Chung, Myung/C-1876-2011; Park, Chang/J-8409-2016 | 57219956574; 35893853100; 57193992783; 57195310676; 57216496820; 57193577386; 57192422019; 55862597800; 55910532600; 59080545400; 7402897119; 55515341400; 57196009389; 55728272500; 56436943800; 57192908764; 57220153071; 58097828800; 57027170100; 16234023200; 35313444300; 57706214000 | jeongyj@pusan.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 34 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0 | 2025-06-25 | 0 | 0 | erratum | English | 2023 | 2023-08-28 | 10.3346/jkms.2023.38.e298 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Expired Platelet Concentrate Up-Cycling: Growth Factor-Rich Bioproduct Preparation for FBS Substitute | Due to the short storage period, large quantities of platelet concentrate (PC) are expiring. The expired PC cannot be injected into a blood vessel, but the activity of bioactive molecules, especially growth factors, is still preserved. In this paper, we organized a process to obtain a growth factor-rich bioproduct for use as a supplement in human cell culture by optimizing freezing, thawing, and sterilization conditions. Each unit of PC displayed visual differences, diverse biochemical values, and growth factor concentrations. To minimize lot-to-lot variation, we pooled a minimum of 10 PC units. The concentrations of growth factors were maximized through five freeze-thaw cycles for 12 h at -80 degrees C for freezing and for 5 min at 36 degrees C for thawing. We used a cell strainer with 40 mu m pores, followed by a 0.45 mu m filter and a 0.22 mu m filter sequentially to sterilize the bioproduct with minimizing loss. The obtained growth factors remained stable for 4-6 h at room temperature (23 degrees C), 24 h at 4 degrees C, and 12 months at -80 degrees C. Cellular responses to the growth factor-rich bioproduct were tested with primary human renal proximal tubule epithelial cells. The cells exhibited a significantly increased growth rate, compared to the fetal bovine serum (FBS)-treated control group. The cells maintained their characteristic cuboidal shape, and stem cells and renal progenitor cells also preserved their genetic characteristics during culture. Therefore, the growth factor-rich bioproduct isolated from expired PC through our process can be used as a medium supplement to replace FBS in human cell culture for clinical application. | Lee, Eun Hye; Chun, So Young; Yoon, Bo Hyun; Jeon, Minji; Ha, Yun-Sok; Chung, Jae-Wook; Kwon, Joonbeom; Kim, Jeongshik; Hwan Kim, Dae; Park, Sang-Joon; Kwon, Tae Gyun; Kim, Bum Soo; Kim, Hyun Tae | Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu 41566, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu 41944, South Korea; Daegu Fatima Hosp, Dept Urol, Daegu 41199, South Korea; Ulsan Joongang Hosp, Dept Pathol, Ulsan 44667, South Korea; Yeungnam Univ, Dept Lab Anim Res Support Team, Daegu 42415, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Histol, Daegu 41566, South Korea | Lee, Yun-Soo/AAA-7364-2022; Kim, Soo-Yeon/ADR-9663-2022 | 57189661699; 8688166900; 57218931150; 59026085100; 35487226400; 35204798500; 57198430572; 57190736920; 55897992900; 7501825941; 15073765400; 57202817150; 55739531300 | eun90hye@gmail.com;soyachun99@naver.com;bobo1904@naver.com;njiya120@naver.com;yunsokha@gmail.com;jeus119@hanmail.net;aziru98@gmail.com;kjspath@hanmail.net;ikorando5@hanmail.net;psj26@knu.ac.kr;tgkwon@knu.ac.kr;urokbs@knu.ac.kr;urologistk@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 23 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0 | 2025-06-25 | 0 | 0 | expired platelet concentrate (PC); growth factors; human stem cell culture; fetal bovine serum (FBS); medium supplement | CELLS | expired platelet concentrate (PC); fetal bovine serum (FBS); growth factors; human stem cell culture; medium supplement | growth factor; thrombocyte concentrate; Article; blood vessel; controlled study; epithelium cell; fetal bovine serum; freeze thawing; freezing; genetic trait; growth rate; human; human cell; human cell culture; instrument sterilization; kidney proximal tubule; room temperature; stem cell culture; thawing; thrombocyte rich plasma | English | 2023 | 2023-12 | 10.3390/jcm12237345 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Editorial Material | Immune Responses and Breakthrough Infections After COVID-19 Vaccination | Kwon, Ki Tae | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea; Kyungpook Natl Univ, Dept Internal Med, Div Infect Dis, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea | ; Kim, Hanjin/KYP-2633-2024 | 9733850500 | ktkwon@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 20 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.51 | 2025-06-25 | 2 | 2 | Antibodies, Viral; Breakthrough Infections; COVID-19; COVID-19 Vaccines; Humans; Immunity; Vaccination; SARS-CoV-2 vaccine; virus antibody; breakthrough infection; coronavirus disease 2019; human; immunity; vaccination | English | 2023 | 2023-05-22 | 10.3346/jkms.2023.38.e185 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Impact of Positron Emission Tomography Viability Imaging: Guided Revascularizations on Clinical Outcomes in Patients With Myocardial Scar on Single-Photon Emission Computed Tomography Scans | Background: Positron emission tomography (PET) viability scan is used to determine whether patients with a myocardial scar on single-photon emission computed tomography (SPECT) may need revascularization. However, the clinical utility of revascularization decision-making guided by PET viability imaging has not been proven yet. The purpose of this study was to investigate the impact of PET to determine revascularization on clinical outcomes.Methods: Between September 2012 and May 2021, 53 patients (37 males; mean age = 64 +/- 11 years) with a myocardial scar on MIBI SPECT who underwent PET viability test were analyzed in this study. The primary outcome was a temporal change in echocardiographic findings. The secondary outcome was all-cause mortality.Results: Viable myocardium was presented by PET imaging in 29 (54.7%) patients. Revascularization was performed in 26 (49.1%) patients, including 18 (34.0%) with percutaneous coronary intervention (PCI) and 8 (15.1%) with coronary artery bypass grafting. There were significant improvements in echocardiographic findings in the revascularization group and the viable myocardium group. All-cause mortality was significantly lower in the revascularization group than in the medical therapy-alone group (19.2% vs. 44.4%, log-rank P = 0.002) irrespective of viable (21.4% vs. 46.7%, log-rank P = 0.025) or non-viable myocardium (16.7% vs. 41.7%, log-rank P = 0.046). All-cause mortality was significantly lower in the PCI group than in the medical therapy-alone group (11.1% vs. 44.4%, log-rank P < 0.001).Conclusion: Revascularization improved left ventricular systolic function and survival of patients with a myocardial scar on SPECT scans, irrespective of myocardial viability on PET scans. | Park, Jong Sung; Lee, Jang Hoon; Hong, Chae Moon; Park, Bo Eun; Park, Yoon Jung; Kim, Hong Nyun; Kim, Namkyun; Jang, Se Yong; Bae, Myung Hwan; Yang, Dong Heon; Park, Hun Sik; Cho, Yongkeun | Kyungpook Natl Univ Hosp, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea | Park, Hang-soo/AEH-1640-2022 | 58363053000; 54581258000; 37050876700; 57201131446; 57216539556; 56706769800; 55887032700; 57207977889; 36607356800; 35277423400; 57198844106; 9249593500 | ljhmh75@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 46 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.51 | 2025-06-25 | 2 | 2 | Myocardial Scar; Positron Emission Tomography; Single-Photon Emission Computed Tomography; Revascularization; Percutaneous Coronary Intervention; Prognosis | LEFT-VENTRICULAR DYSFUNCTION; CORONARY-ARTERY-DISEASE; INFARCTION | Myocardial Scar; Percutaneous Coronary Intervention; Positron Emission Tomography; Prognosis; Revascularization; Single-Photon Emission Computed Tomography | Aged; Cicatrix; Humans; Male; Middle Aged; Myocardium; Percutaneous Coronary Intervention; Positron-Emission Tomography; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; aged; cardiac muscle; computer assisted emission tomography; human; male; middle aged; percutaneous coronary intervention; positron emission tomography; scar; single photon emission computed tomography; x-ray computed tomography | English | 2023 | 2023-11-27 | 10.3346/jkms.2023.38.e399 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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