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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Application of silver-assisted laser desorption ionization ultrahigh-resolution mass spectrometry for the speciation of sulfur compounds | We herein report the optimization and application of silver cationization (Ag+) in combination with laser desorption ionization (LDI) ultrahigh-resolution mass spectrometry (UHR-MS) to determine the structures of the sulfur-containing compounds present in heavy crude oil. A number of sulfur-containing model compounds were used to optimize the positive-ion mode LDI-MS conditions in the presence of a silver-complexing agent. Under the optimized LDI conditions, sulfur-rich heavy oil fractions were treated with the silver salt, where Ag+ coordinated with the sulfur atoms to speciate the sulfur species. The obtained results suggested that benzothiophenic, naphtheno-non-aromatic sulfides, and non-aromatic thiols were the major components present in the analyzed oil sample. | Acter, Thamina; Solihat, Nissa Nurfajrin; Kim, Sungjune; Uddin, Nizam; Mustafa, Ahmad Ismail; Shamsuddin, Sayed Md; Kim, Sunghwan | East West Univ, Dept Math & Phys Sci, A-2 Jahurul Islam Ave, Dhaka 1212, Bangladesh; Univ Dhaka, ILET, Dhaka 1000, Bangladesh; Indonesian Inst Sci LIPI, Res Ctr Biomat, Cibinong 16911, Indonesia; Kyungpook Natl Univ, Dept Chem, 80 Daehak Ro, Daegu 41566, South Korea; Daffodil Int Univ, Fac Allied Hlth Sci, Dept Nutr & Food Engn, 102 Shukrabad,Mirpur Rd, Dhaka 1207, Bangladesh; Univ Dhaka, Fac Engn & Technol, Dept Appl Chem & Chem Engn ACCE, Dhaka 1000, Bangladesh; Green Nano Mat Res Ctr, 80 Daehak Ro, Daegu 41566, South Korea | Solihat, Nissa/GVT-7174-2022; Kim, Sunghwan/HKN-9812-2023; Uddin, Nizam/N-3536-2014; Uddin, Dr. Nizam/N-3536-2014 | 56768064900; 57199653322; 57221297786; 57188533756; 7101901688; 36917093700; 57203772967 | sunghwank@knu.ac.kr; | ANALYTICAL AND BIOANALYTICAL CHEMISTRY | ANAL BIOANAL CHEM | 1618-2642 | 1618-2650 | 412 | 1 | SCIE | BIOCHEMICAL RESEARCH METHODS;CHEMISTRY, ANALYTICAL | 2020 | 4.157 | 24.7 | 0.46 | 2025-06-25 | 9 | 9 | Silver cationization; Ultrahigh-resolution mass spectrometry; Laser desorption ionization; Fourier transform ion cyclotron resonance mass spectrometry | ATMOSPHERIC-PRESSURE PHOTOIONIZATION; MOLECULAR-WEIGHT DISTRIBUTIONS; CRUDE OILS; PETROLEUM FRACTIONS; NAPHTHENIC ACIDS; THIYL RADICALS; HDX MS; CATIONIZATION; IDENTIFICATION; OPTIMIZATION | Fourier transform ion cyclotron resonance mass spectrometry; Laser desorption ionization; Silver cationization; Ultrahigh-resolution mass spectrometry | Aromatic compounds; Crude oil; Desorption; Heavy oil production; Ionization; Mass spectrometry; Positive ions; Silver halides; Cationization; Fourier transform ion cyclotron resonance mass spectrometry; Heavy oil fractions; Laser desorption ionization; Positive ion mode; Speciation of sulfur; Sulfur containing compound; Ultrahigh resolution mass spectrometries; Sulfur compounds | English | 2020 | 2020-01 | 10.1007/s00216-019-02272-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Inhibition of Tumor Growth against Chemoresistant Cholangiocarcinoma by a Proapoptotic Peptide Targeting Interleukin-4 Receptor | Cholangiocarcinoma (CCA) has a poor prognosis and high chemoresistance. Interleukin-4 receptor (IL-4R) is overexpressed in several cancer cells and plays a crucial role in tumor progression and drug resistance. IL4RPep-1, an IL-4R-binding peptide, has been identified by phage display and used for tumor targeting. In this study, we exploited IL4RPep-1 to guide the tumor-specific delivery of a proapoptotic peptide to chemoresistant CCA, thereby inhibiting tumor growth. Immunohistochemistry of human primary CCA tissues showed that IL-4R levels were upregulated in moderately to poorly differentiated types, and higher levels of IL-4R are correlated with lower survival rates in patients with CCA. IL4RPep-1 was observed to preferentially bind with high IL-4R-expressing KKU-213 human CCA cells, whereas it barely bound with low IL-4R-expressing KKU-055 cells. A hybrid of IL4RPep-1 and a proapoptotic peptide (KLAKLAK)2 (named as IL4RPep-1-KLA) induced cytotoxicity and apoptosis in KKU-213 cells and increased those levels induced by 5-fluorouracil (5-FU). IL4RPep-1-KLA was internalized in the cells and colocalized with mitochondria. Whole-body fluorescence imaging and immunohistochemical analysis of tumor tissues showed the homing of IL4RPep-1-KLA as well as IL4RPep-1 to KKU-213 tumor in mice. Systemic administration of IL4RPep-1-KLA efficiently inhibited KKU-213 tumor growth, whereas treatment with 5-FU alone did not significantly inhibit tumor growth in mice. No significant systemic side effects including liver toxicity and immunotoxicity were observed in mice during peptide treatments. These findings suggest that IL4RPep-1-KLA holds potential as a targeted therapeutic agent against chemoresistant CCA. | Permpoon, Uttapol; Khan, Fatima; Vadevoo, Sri Murugan Poonkavithai; Gurung, Smriti; Gunassekaran, Gowri Rangaswamy; Kim, Min-Jong; Kim, Sang-Hyun; Thuwajit, Peti; Lee, Byungheon | Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Biochem & Cell Biol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Div Biomed Sci, Daegu 41944, South Korea; Mahidol Univ, Siriraj Hosp, Fac Med, Dept Immunol, Bangkok 10700, Thailand; Kyungpook Natl Univ, Sch Med, Div Biomed Sci, Cell & Matrix Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea | ; Thuwajit, Peti/AAD-1014-2021; Khan, Fatima/GQP-2552-2022 | 57205752273; 57205752395; 56663280000; 57205752137; 36028043400; 57192888932; 57210450420; 6507562284; 16304374900 | peti.thu@mahidol.edu;leebh@knu.ac.kr; | MOLECULAR PHARMACEUTICS | MOL PHARMACEUT | 1543-8384 | 1543-8392 | 17 | 11 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2020 | 4.939 | 24.8 | 0.51 | 2025-06-25 | 11 | 10 | chemoresistance; cholangiocarcinoma; 5-fluorouracil; IL-4 receptor; proapoptotic peptide | KEYHOLE LIMPET HEMOCYANIN; ANTITUMOR-ACTIVITY; ANTICANCER ACTIVITY; IN-VITRO; DELIVERY; CELLS; IL-4; CHEMOTHERAPY; MECHANISMS; RESPONSES | 5-fluorouracil; chemoresistance; cholangiocarcinoma; IL-4 receptor; proapoptotic peptide | Animals; Apoptosis; Bile Duct Neoplasms; Carcinogenesis; Cell Line, Tumor; Cholangiocarcinoma; Drug Delivery Systems; Drug Resistance, Neoplasm; Fluorouracil; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-4 Receptor alpha Subunit; Mice; Mice, Inbred BALB C; Mice, Nude; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays; alanine aminotransferase; alkaline phosphatase; creatinine; fluorouracil; immunoglobulin G2a; interleukin 4 receptor; fluorouracil; IL4R protein, human; interleukin 4 receptor alpha; KLA peptide; signal peptide; alanine aminotransferase blood level; alkaline phosphatase blood level; animal experiment; animal tissue; apoptosis; Article; bile duct carcinoma; body weight change; cancer inhibition; chemosensitivity; controlled study; creatinine blood level; cytoplasm; cytotoxicity; ex vivo study; human; human cell; IC50; immune response; immunohistochemistry; immunotoxicity; in vivo study; internalization (cell); kidney; liver; lung; mouse; nonhuman; priority journal; spleen; spleen weight; survival rate; tumor volume; tumor weight; animal; Bagg albino mouse; bile duct cancer; bile duct carcinoma; carcinogenesis; chemistry; drug delivery system; drug effect; drug resistance; drug screening; metabolism; nude mouse; pathology; procedures; treatment outcome; tumor cell line | English | 2020 | 2020-11-02 | 10.1021/acs.molpharmaceut.0c00529 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Alterations in power spectral density in motor- and pain-related networks on neuropathic pain after spinal cord injury | Background: The mechanisms by which mobility function and neuropathic pain are mutually influenced by supraspinal plasticity in motor- and pain-related brain networks following spinal cord injury (SCI) remains poorly understood. Objective: To determine cortical and subcortical resting-state network alterations using power spectral density (PSD) analysis and investigate the relationships between these intrinsic alterations and mobility function and neuropathic pain following SCI. Methods: A total of 41 patients with incomplete SCI and 33 healthy controls were included. The degree of mobility and balance function and severity of neuropathic pain and depressive mood were evaluated. The resting-state functional magnetic resonance imaging data of low-frequency fluctuations were analyzed based on PSD. Differences in PSD values between patients with SCI and controls were assessed using the two-sample t-test (false discovery rate-corrected P < 0.05). The relationship between PSD values and mobility function and pain intensity was assessed using Pearson's correlation coefficient adjusted for the severity of depressive mood. Results: Compared with healthy controls, lower PSD values in supplementary motor and medial prefrontal areas (the anterior cingulate cortex, ventral medial prefrontal cortex, and superior orbito-prefrontal cortex) were associated with greater pain severity and poorer postural balance and mobility (P < 0.05) in patients with SCI, whereas higher PSD values in the primary motor cortex, premotor cortex, thalamus, and periaqueductal gray were associated with greater pain severity and poorer postural balance and mobility (P < 0.05). Conclusions: Cortical and subcortical plastic alterations in intrinsic motor- and pain-related networks were observed in patients with SCI and were simultaneously associated with neuropathic pain intensity and degree of mobility function. | Park, Eunhee; Cha, Hyunsil; Kim, Eunji; Min, Yu-Sun; Kim, Ae Ryoung; Lee, Hui Joong; Jung, Tae-Du; Chang, Yongmin | Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Rehabil Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Med & Biol Engn, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 56107216400; 57189728122; 57215273419; 48061349800; 57196257330; 23485776600; 36622364500; 7501840633 | teeed0522@hanmail.net; | NEUROIMAGE-CLINICAL | NEUROIMAGE-CLIN | 2213-1582 | 28 | SCIE | NEUROIMAGING | 2020 | 4.881 | 25.0 | 0.7 | 2025-06-25 | 11 | 13 | Power spectral density; Resting-state functional magnetic resonance imaging; Mobility; Neuropathic pain; Spinal cord injury | MIDBRAIN PERIAQUEDUCTAL GRAY; INTERNATIONAL STANDARDS; BRAIN-STEM; CORTEX; CLASSIFICATION; REORGANIZATION; CONNECTIONS; DISABILITY; MONKEYS; ATROPHY | Mobility; Neuropathic pain; Power spectral density; Resting-state functional magnetic resonance imaging; Spinal cord injury | Adult; Aged; Brain; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuralgia; Pain Measurement; Spinal Cord Injuries; adult; aged; anterior cingulate; Article; body equilibrium; clinical article; controlled study; correlation coefficient; depression; disease severity; evaluation study; female; functional magnetic resonance imaging; human; male; nerve cell network; neuropathic pain; orbital cortex; pain intensity; periaqueductal gray matter; prefrontal cortex; premotor cortex; primary motor cortex; priority journal; resting state network; spectroscopy; spinal cord injury; Student t test; thalamus; ventromedial prefrontal cortex; brain; complication; diagnostic imaging; middle aged; neuralgia; nuclear magnetic resonance imaging; pain measurement | English | 2020 | 2020 | 10.1016/j.nicl.2020.102342 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Characteristics and outcomes of HFpEF with declining ejection fraction | Objective Some patients with heart failure with preserved ejection fraction (HFpEF) experience declining of left-ventricular ejection fraction (LVEF) during follow-up. We aim to investigate the characteristics and outcomes of patients with HF with declining ejection fraction (HFdEF). Methods We analyzed a prospective, nationwide multicenter cohort with consecutive patients with acute HF enrolled from March 2011 to December 2014. HFpEF was defined as LVEF >= 50% at index admission. After 1 year, HFpEF patients were further classified as HFdEF (LVEF >= 50% at admission and = 50% both at admission and 1 year). Primary outcome was 4-year all-cause mortality according to HF type from HFdEF diagnosis. Results Of patients with HFpEF, 426 (90.4%) were diagnosed as having persistent HFpEF and 45 (9.6%) as having HFdEF. Natriuretic peptide level was an independent predictor of HFdEF (natriuretic peptide level > median: odds ratio: 3.20, 95% confidence interval [CI]: 1.42-7.25, P = 0.005). During 4-year follow-up, patients with HFdEF had higher mortality than those with persistent HFpEF (Log-rank P < 0.001). After adjustment, HFdEF was associated with an almost twofold increased risk for mortality (hazard ratio 1.82, 95% CI 1.13-2.96, P = 0.015). The use of beta-blockers, renin-angiotensin system inhibitors, and mineralocorticoid receptor antagonists was not associated with improved prognosis of patients with HFdEF. Conclusions HFdEF is a distinct HF type with grave outcomes. Further investigations that focus on HFdEF are warranted to better understand and develop treatment strategies for these high-risk patients. Graphic abstract [GRAPHICS] . | Park, Jin Joo; Park, Chan Soon; Mebazaa, Alexandre; Oh, Il-Young; Park, Hyun-Ah; Cho, Hyun-Jai; Lee, Hae-Young; Kim, Kye Hun; Yoo, Byung-Su; Kang, Seok-Min; Baek, Sang Hong; Jeon, Eun-Seok; Kim, Jae-Joong; Cho, Myeong-Chan; Chae, Shung Chull; Oh, Byung-Hee; Choi, Dong-Ju | Seoul Natl Univ, Bundang Hosp, Cardiovasc Ctr, Div Cardiol, Gumiro 166, Seongnam, Gyeonggi Do, South Korea; Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea; Univ Paris Diderot, Hop Univ St Louis Lariboisiere, AP HP, Dept Anesthesiol & Intens Care Med,UMR 942 Inserm, Paris, France; Inje Univ, Seoul Paik Hosp, Dept Family Med, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ, Heart Res Ctr, Gwangju, South Korea; Yonsei Univ, Wonju Coll Med, Wonju, South Korea; Yonsei Univ, Coll Med, Seoul, South Korea; Catholic Univ Korea, Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Asan Med Ctr, Div Cardiol, Seoul, South Korea; Chungbuk Natl Univ, Coll Med, Cheongju, South Korea; Kyungpook Natl Univ, Coll Med, Daegu, South Korea; Mediplex Sejong Hosp, Incheon, South Korea | Oh, Byung-Hee/G-9875-2011; choi, jo/O-5940-2014; Deniau, Benjamin/AAU-7314-2021; Oh, Il-Young/ACC-0418-2022; Choi, Dong-Ju/J-5686-2012; Jeong, Gi/AAB-2830-2021 | 35799900000; 57198830480; 57210091243; 8724022000; 13405439400; 35285421400; 56151235500; 56150430800; 7102851884; 7405685375; 7201371594; 7004279641; 36065764100; 7401727518; 7101962036; 57216293873; 35274349200 | djchoi@snubh.org; | CLINICAL RESEARCH IN CARDIOLOGY | CLIN RES CARDIOL | 1861-0684 | 1861-0692 | 109 | 2 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS | 2020 | 5.46 | 25.0 | 1.73 | 2025-06-25 | 18 | 22 | Heart failure with declining ejection fraction; Predictor; Prognosis; Mortality; Treatment | HEART-FAILURE PATIENTS; NT-PROBNP; PATHOPHYSIOLOGY; ASSOCIATION; DIAGNOSIS | Heart failure with declining ejection fraction; Mortality; Predictor; Prognosis; Treatment | Aged; Aged, 80 and over; Cardiovascular Agents; Comorbidity; Disease Progression; Female; Heart Failure; Humans; Male; Middle Aged; Prospective Studies; Recovery of Function; Registries; Republic of Korea; Risk Factors; Stroke Volume; Time Factors; Treatment Outcome; Ventricular Function, Left; amino terminal pro brain natriuretic peptide; beta adrenergic receptor blocking agent; dipeptidyl carboxypeptidase inhibitor; mineralocorticoid antagonist; cardiovascular agent; aged; all cause mortality; Article; body mass; cardiogenic shock; cardiovascular mortality; cerebrovascular disease; chronic obstructive lung disease; clinical outcome; cohort analysis; comparative study; controlled study; diastolic blood pressure; echocardiography; female; follow up; heart failure with reduced ejection fraction; heart left ventricle ejection fraction; heart ventricle size; hospital admission; human; incidence; ischemic heart disease; kidney disease; left ventricular systolic dysfunction; major clinical study; male; multicenter study; New York Heart Association class; propensity score; renin angiotensin aldosterone system; sensitivity analysis; systolic blood pressure; urea nitrogen blood level; valvular heart disease; clinical trial; comorbidity; convalescence; disease exacerbation; drug effect; heart failure; heart left ventricle function; heart stroke volume; middle aged; mortality; pathophysiology; prospective study; register; risk factor; South Korea; time factor; treatment outcome; very elderly | English | 2020 | 2020-02 | 10.1007/s00392-019-01505-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Characterization of overwintering sites of Haemaphysalis longicornis (Acari: Ixodidae) and tick infection rate with severe fever with thrombocytopenia syndrome virus from eight provinces in South Korea | Haemaphysalis longicornis (Acari: Ixodidae) is an important vector of pathogens causing tick-borne diseases such as severe fever with thrombocytopenia syndrome (SFTS) in eastern Asia. Although an understanding of the overwintering ecology of ticks is fundamental to management of this vector, its winter biology remains unclear. Therefore, we conducted a field survey from eight provinces in South Korea to characterize overwintering sites of H. longicornis and investigate their SFTS virus infection rates. First, we conducted flagging which consists of horizontal sweeping of a 1 m(2) cloth back-and-forth to collect ticks that may exhibit questing behaviors in four different landscapes: grassland, shrub, coniferous forest, and deciduous forest. From 640 sweeps of flagging (where each sweep covered 3.8 m(2)), we collected five unfed ixodid ticks. However, H. longicornis was not found. After the flagging, to locate overwintering ticks, we inspected a total of 679 samples consisting of three different structures: ground (leaf litter, soil surface, and topsoil layer), rocks, and dead trees. From the samples inspected, 85 unfed overwintering ixodid ticks were found. Haemaphysalis longicornis was the dominant species (88 %), and mostly nymphs were collected (94 %). This species was collected from ground samples, especially from the topsoil layer. Most H. longicornis were found in herbaceous landscapes such as grassland (46 %) and shrub (52 %). SFTS virus was found in 3 out of 38 pools of unfed nymphs (minimal infection rate: 4 %). Our results can serve as baseline information for the development of vector management programs. | Kim, Joo-Young; Jung, Minhyung; Kho, Jung-Wook; Song, Hyunsung; Moon, KyungHwan; Kim, Young Ho; Lee, Doo-Hyung | Gachon Univ, Dept Life Sci, Seongnam Si, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Ecol Sci, Sangju Si, Gyeongsangbuk D, South Korea | Kim, Young/J-5414-2012 | 57207883191; 57188649986; 57203589968; 57209221785; 57202874378; 58516491300; 55649570824 | DL343@gachon.ac.kr; | TICKS AND TICK-BORNE DISEASES | TICKS TICK-BORNE DIS | 1877-959X | 1877-9603 | 11 | 5 | SCIE | INFECTIOUS DISEASES;MICROBIOLOGY;PARASITOLOGY | 2020 | 3.744 | 25.0 | 1.11 | 2025-06-25 | 16 | 16 | Vector biology; Longhorned tick; Overwintering ecology | INSECT COLD-HARDINESS; BISEXUAL POPULATIONS; CYTOGENETICS; TOLERANCE; IXODOIDEA; FREEZE; JAPAN | Longhorned tick; Overwintering ecology; Vector biology | Animal Distribution; Animals; Ixodidae; Larva; Nymph; Phlebovirus; Republic of Korea; Seasons; adult; Article; controlled study; grassland; Haemaphysalis longicornis; infection rate; leaf litter; nonhuman; nymph; overwintering; polymerase chain reaction; priority journal; rock; severe fever with thrombocytopenia syndrome; shrub; soil property; South Korea; taiga; temperate deciduous forest; tick borne disease; tree; animal; animal dispersal; growth, development and aging; isolation and purification; Ixodidae; larva; Phlebovirus; physiology; season; virology | English | 2020 | 2020-09 | 10.1016/j.ttbdis.2020.101490 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Molecular detection and phylogenetic analysis of canine tick-borne pathogens from Korea | Ticks transmit more pathogens than any other arthropod vector and are of paramount veterinary and zoonotic significance. Domestic dogs are an important reservoir of zoonotic agents, particularly because of their close contact with humans. Previous studies in Korea have examined canine tick-borne pathogens (CTBP) by ELISA and real-time PCR methods. However, phylogenetic information on CTBP in Korea is lacking. This study assessed the prevalence, risk factors, and co-infectivity of CTBP such as piroplasms, rickettsiae, Coxiella burnetii, hepatozoa, hemotropic mycoplasmas, and Borrelia spp., using PCR and phylogenetic analyses. Of the 510 dogs tested, three CTBP, including Anaplasma phagocytophilum 16S rRNA (13; 2.6 %), Hepatozoon canis 18S rRNA (2; 0.4 %), and Mycoplasma haemocanis 16S rRNA (1; 0.2 %) were detected. PCR adapted to amplify A. phagocytophilum msp2 and groEL genes generated amplicons thereof in two out of 13 positive dogs. One shelter dog was coinfected with A. phagocytophilum and M. haemocanis. However, Ehrlichia spp., Rickettsia spp., C. burnetii, Borrelia spp., Babesia spp., and Theileria spp. pathogens were not detected. To the best of our knowledge, this is the first study to undertake a phylogenetic analysis of H. canis and M. haemocanis in dogs reared in Korea. Although previous studies have improved our understanding of evolutionary behaviors and host-pathogen relations of CTBP, additional investigations are required to pin down vectors and reservoirs of CTBP in Korea. A surveillance system for arthropod vectors and CTBP in dogs should be established to monitor pathogen distribution and mitigate pathogen spread proactively, such as with ectoparasite medications in dogs. | Seo, Min-Goo; Kwon, Oh-Deog; Kwak, Dongmi | Anim & Plant Quarantine Agcy, Gimcheon 39660, Gyeongbuk, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea | ; Seo, Min-Goo/NQF-4335-2025 | 53982155300; 7402195886; 7007148758 | koreasmg@korea.kr;odkwon@knu.ac.kr;dmkwak@knu.ac.kr; | TICKS AND TICK-BORNE DISEASES | TICKS TICK-BORNE DIS | 1877-959X | 1877-9603 | 11 | 2 | SCIE | INFECTIOUS DISEASES;MICROBIOLOGY;PARASITOLOGY | 2020 | 3.744 | 25.0 | 0.93 | 2025-06-25 | 13 | 14 | Canine tick-borne pathogens; Phylogeny; Multilocus genotyping | ANAPLASMA-PHAGOCYTOPHILUM; HEPATOZOON-CANIS; GENETIC-VARIANTS; DOMESTIC DOGS; SHELTER DOGS; CATTLE; DEER; IDENTIFICATION; TRANSMISSION; HEMOPLASMAS | Canine tick-borne pathogens; Multilocus genotyping; Phylogeny | Animals; Coinfection; Dog Diseases; Dogs; Phylogeny; Prevalence; Republic of Korea; Risk Factors; Tick-Borne Diseases; RNA 16S; RNA 18S; adult; Anaplasma phagocytophilum; Article; Babesia; Borrelia; controlled study; Coxiella burnetii; dog; Ehrlichia; female; gene; groEL gene; Hepatozoon canis; host pathogen interaction; Korea; male; mixed infection; molecular diagnosis; molecular evolution; msp2 gene; Mycoplasma; nonhuman; phylogeny; piroplasmosis; polymerase chain reaction; priority journal; Rickettsia; risk factor; Theileria; tick; tick borne disease; animal; dog disease; microbiology; mixed infection; parasitology; phylogeny; prevalence; South Korea; tick borne disease; veterinary medicine | English | 2020 | 2020-03 | 10.1016/j.ttbdis.2019.101357 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Optimization and sustainability analysis of PV/wind/diesel hybrid energy system for decentralized energy generation | This paper focuses on the techno-economic feasibility and sustainability of a PV/wind/diesel hybrid system designed for decentralized power supply. Several designs have been studied for the hybrid system by varying the PV slope and wind turbine hub height under different dispatch strategies to supply the load. For each design, the power system has been optimized to determine the maximum electrical output at a low cost. Sensitivity analyses have been performed to evaluate operational risk in the actual operation as well as the cost-effectiveness of the proposed system. As a final remark, the sustainability of the proposed hybrid energy system has been analyzed based on some key indicators to understand the implications of a design choice on electrical production, CO2 emission and cost of energy. Our results show that for a projected period of 25 years, the selected hybrid power system for electrification of a housing estate will cost 10.2 million USD for a daily load of 4876.5 kWh, and the cost for every kWh of electricity generated is $0.4574. Results also show that the hybridization of the standard diesel generating system increased the reliability and cost-effectiveness of the power system, saving $0.316 for every kWh of electricity generated, with about 1,521,310 kg of CO2 emission avoided annually. | Nsafon, Benyoh Emmanuel Kigha; Owolabi, Abdulhameed Babatunde; Butu, Hemen Mark; Roh, Jong Wook; Suh, Dongjun; Huh, Jeung-Soo | Kyungpook Natl Univ, Inst Global Climate Change & Energy, Grad Sch, Dept Climate Change, Daegu 41566, South Korea | ; Butu, Hemen/MBH-0863-2025 | 57211664452; 57192210107; 57214246289; 25638796100; 36613529600; 7102258915 | luxnsafon@yahoo.ca;jshuh@knu.ac.kr; | ENERGY STRATEGY REVIEWS | ENERGY STRATEG REV | 2211-467X | 2211-4688 | 32 | SCIE | ENERGY & FUELS | 2020 | 6.425 | 25.0 | 1.81 | 2025-06-25 | 40 | 50 | Optimization; Energy sustainability indicators; Photovoltaic; Wind energy; Decentralized | TECHNOECONOMIC ANALYSIS; SIZE OPTIMIZATION; POWER-SYSTEM; FEASIBILITY | Decentralized; Energy sustainability indicators; Optimization; Photovoltaic; Wind energy | Carbon dioxide; Cost effectiveness; Electric power generation; Electric power systems; Hybrid systems; Sensitivity analysis; Sustainable development; Decentralized energy; Decentralized power supplies; Dispatch strategy; Electrical output; Hybrid energy system; Hybrid power systems; Sustainability analysis; Techno-economic feasibility; Cost benefit analysis | English | 2020 | 2020-11 | 10.1016/j.esr.2020.100570 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Radiographic progression based on baseline characteristics from TNF inhibitor biosimilar studies in patients with rheumatoid arthritis | Objective Phase III clinical trials of the tumour necrosis factor inhibitors SB4, SB2, and SB5 (biosimilars to etanercept, infliximab, and adalimumab, respectively) have demonstrated efficacy in moderate-to-severe rheumatoid arthritis (RA). Data from these trials were used to identify baseline characteristics associated with radiographic progression and to build a matrix risk model for its prediction. Methods Patients with radiographic progression and baseline demographic and disease characteristic data were pooled across the 3 phase III studies of each biosimilar and its reference product. Baseline demographics and disease characteristics were evaluated for their relationship with radiographic progression (1-year mean change in mTSS > 0); 3 factors were selected based on strongest Pearson's correlation coefficient with the change in modified Total Sharp Score. Univariate logistic regression was performed to assess the association between each baseline factor and the rate of radiographic progression, with subsequent matrix model development performed using multivariate logistic regression. Results A total of 1371 patients were included in the analysis, with a radiographic progression rate of 27.4%. The 3 baseline predictors of radiographic progression, based on Pearson's correlation coefficient, were 28 swollen joint count (SJC28), C-reactive protein (CRP), and physician global assessment (PhGA). A matrix model showed that the predicted risk of radiographic progression was higher with the increased level of SJC28, CRP, and PhGA (P < 0.001). Conclusions In this pooled analysis of phase III clinical trial data of biosimilars for RA, identifiable baseline factors (SJC28, CRP, and PhGA) associated with radiographic progression were similar to those described in prior studies. Even though radiographic progression was minimal, a small number of patients who have increased SJC28, CRP, and PhGA at baseline should be closely monitored and follow treat-to-target approach. | Smolen, Josef S.; Kang, Young Mo; Yoo, Wan-Hee; Emery, Paul; Weinblatt, Michael E.; Keystone, Edward C.; Genovese, Mark C.; Myung, Gihyun; Baek, Inyoung; Ghil, Jeehoon | Med Univ Vienna, Dept Med, Div Rheumatol, Waehinger Guertel 18-20, A-1090 Vienna, Austria; Kyungpook Natl Univ, Dept Internal Med, Div Rheumatol, Sch Med, Daegu, South Korea; Chonbuk Natl Univ Hosp, Dept Internal Med, Div Rheumatol, Jeonju, South Korea; Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England; Harvard Med Sch, Div Rheumatol Immunol & Allergy, Brigham & Womens Hosp, Boston, MA 02115 USA; Univ Toronto, Mt Sinai Hosp, Div Rheumatol, Toronto, ON, Canada; Stanford Univ, Med Ctr, Div Immunol & Rheumatol, Stanford, CA 94305 USA; Samsung Bioepis Co Ltd, Incheon, South Korea | Smolen, Josef/ADI-7087-2022; emery, paul/B-3560-2013; Li, Shaofu/O-2241-2019 | 57211726941; 26221798000; 7102197467; 7201777137; 7005257845; 7004943164; 7006671573; 57193419467; 57201857595; 56730934800 | josef.smolen.ard@meduniwien.ac.at; | ARTHRITIS RESEARCH & THERAPY | ARTHRITIS RES THER | 1478-6354 | 1478-6362 | 22 | 1 | SCIE | RHEUMATOLOGY | 2020 | 5.156 | 25.0 | 0.14 | 2025-06-25 | 2 | 2 | Biosimilar; TNF inhibitors; Rheumatoid arthritis; Radiography | ANTITUMOR NECROSIS FACTOR; ADALIMUMAB PLUS METHOTREXATE; RECEIVING CONCOMITANT METHOTREXATE; DISEASE-ACTIVITY; MONOCLONAL-ANTIBODY; JOINT DAMAGE; DOUBLE-BLIND; COMBINATION ETANERCEPT; TREATMENT STRATEGIES; READ RADIOGRAPHS | Biosimilar; Radiography; Rheumatoid arthritis; TNF inhibitors | adalimumab; C reactive protein; etanercept; infliximab; 28 swollen joint count; adult; Article; controlled study; correlation coefficient; demography; disease course; disease duration; double blind procedure; drug efficacy; drug safety; female; human; major clinical study; male; phase 3 clinical trial; physician global assessment; prediction; questionnaire; randomized controlled trial; rheumatoid arthritis; risk factor; swollen joint count | English | 2020 | 2020-08-14 | 10.1186/s13075-020-02267-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Severe fever with thrombocytopenia syndrome in canines from the Republic of Korea | Severe fever with thrombocytopenia syndrome (SFTS) in a companion dog was confirmed based on clinical symptoms, virus isolation, and virus-specific antibody detection. Fever and anorexia began after tick bite. Viremia disappeared within two weeks and antibodies were detected one week after disease onset. | Han, Sun-Woo; Kang, Jun-Gu; Byeon, A-Ram; Cho, Yoon-Kyoung; Choi, Kyoung-Seong; Chae, Joon-Seok | Seoul Natl Univ, Res Inst Vet Sci, Lab Vet Internal Med, PLUS Program Creat Vet Sci Res BK21, 1 Gwanak Ro, Seoul 08826, South Korea; Seoul Natl Univ, Coll Vet Med, 1 Gwanak Ro, Seoul 08826, South Korea; Seoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea; Seoul Natl Univ, Dept Biomed Sci, Med Res Ctr, Seoul 03080, South Korea; Apple Anim Hosp, Chungju 27359, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Sangju 37224, South Korea | 57216636732; 40561359000; 57216629611; 57201634305; 7403949556; 7102478039 | suntina227@snu.ac.kr;herculess@snu.ac.kr;apple-ah@naver.com;hmhm0410@snu.ac.kr;kschoi3@knu.ac.kr;jschae@snu.ac.kr; | TICKS AND TICK-BORNE DISEASES | TICKS TICK-BORNE DIS | 1877-959X | 1877-9603 | 11 | 4 | SCIE | INFECTIOUS DISEASES;MICROBIOLOGY;PARASITOLOGY | 2020 | 3.744 | 25.0 | 1.11 | 2025-06-25 | 16 | 16 | Canine; Severe fever with thrombocytopenia syndrome; Virus; Ticks | SYNDROME VIRUS; SOUTH-KOREA | Canine; Severe fever with thrombocytopenia syndrome; Ticks; Virus | Animals; Anorexia; Antibodies, Viral; Dog Diseases; Dogs; Phlebovirus; Republic of Korea; Severe Fever with Thrombocytopenia Syndrome; Viremia; virus antibody; anemia; anorexia; antibody detection; Article; controlled study; decreased appetite; dog; fever; immunofluorescence test; nonhuman; phylogeny; priority journal; real time reverse transcription polymerase chain reaction; severe fever with thrombocytopenia syndrome; South Korea; thrombocytopenia; tick bite; Vero C1008 cell line; virus isolation; animal; anorexia; blood; case report; complication; dog disease; isolation and purification; Phlebovirus; severe fever with thrombocytopenia syndrome; veterinary medicine; viremia; virology | English | 2020 | 2020-07 | 10.1016/j.ttbdis.2020.101454 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Continentalic acid exhibited nephroprotective activity against the LPS and E. coli-induced kidney injury through inhibition of the oxidative stress and inflammation | The present study investigated the effect of the continentalic acid (CNT) isolated from the Aralia Continentalis against the LPS and E. coli-induced nephrotoxicity. The LPS and E. coli administration markedly altered the behavioral parameters including spontaneous pain, tail suspension and survival rate. However, the treatment with CNT dose dependently improved the behavioral parameters. The CNT treatment significantly improved the renal functions test (RFTs) and hematological parameters following LPS and E. coli-induced kidney injury. Furthermore, the LPS and E. coli administration markedly compromised the anti-oxidant enzymes and enhanced the oxidative stress markers. However, the CNT treatment markedly enhanced the anti-oxidants enzymes such as GSH, GST, Catalase and SOD, while attenuated the oxidative stress markers such as MDA and POD. The MPO enzyme is widely used marker for the neutrophilic infiltration, the LPS and E. coli administration markedly increased the MPO activity. However, the CNT treatment markedly attenuated the MPO activity in both LPS and E. coli-induced kidney injury. Furthermore, the CNT treatment markedly attenuated the NO production compared to the LPS and E. coli-induced kidney injury group. Additionally, the CNT treatment improved the histological parameters markedly (H and E, PAS and Masson's trichome staining) and protect the kidney from the inflammatory insult of the LPS and E. coli evidently. The comet assay revealed marked DNA damage, however, the CNT treatment markedly prevented the LPS and E. coli-induced kidney damage. The CNT treatment markedly enhanced the expression of Nrf2, while attenuated the iNOS expression in both models of kidney injury. | Khan, Amir Muhammad; Khan, Ashraf Ullah; Ali, Hussain; Ul Islam, Salman; Seo, Eun Kyoung; Khan, Salman | Quaid I Azam Univ, Dept Pharm, Fac Biol Sci, Islamabad 45320, Pakistan; Kyungpook Natl Univ, Sch Life Sci, Coll Nat Sci, Daegu 41566, South Korea; Ewha Womans Univ, Coll Pharm, 52 Ewhayeodae Gil, Seoul 03760, South Korea | khan, shahan/M-6985-2017; Khan, Muhammad/IXN-8470-2023; Khan, Salman/F-4588-2016 | 57214230785; 57200756218; 56003879200; 56985186700; 7005953758; 54393307500 | skhan@qau.edu.pk; | INTERNATIONAL IMMUNOPHARMACOLOGY | INT IMMUNOPHARMACOL | 1567-5769 | 1878-1705 | 80 | SCIE | IMMUNOLOGY;PHARMACOLOGY & PHARMACY | 2020 | 4.932 | 25.2 | 1.74 | 2025-06-25 | 32 | 30 | LPS; E. coli; Anti-oxidants; Oxidative stress; NO | ESCHERICHIA-COLI; SEPSIS; ATTENUATION; INDUCTION; RESPONSES; ANOMALIN; EXTRACT; LESIONS; ORGAN; NRF2 | Anti-oxidants; E. coli; LPS; NO; Oxidative stress | Acute Kidney Injury; Animals; Aralia; Disease Models, Animal; Diterpenes; Escherichia coli; Humans; Kidney; Lipopolysaccharides; Mice; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Oxidative Stress; Protective Agents; catalase; continentalic acid; diterpenoid; glutathione; glutathione transferase; inducible nitric oxide synthase; lipopolysaccharide; malonaldehyde; myeloperoxidase; peroxidase; superoxide dismutase; transcription factor Nrf2; unclassified drug; continentalic acid; diterpenoid; inducible nitric oxide synthase; lipopolysaccharide; Nfe2l2 protein, mouse; Nos2 protein, mouse; protective agent; transcription factor Nrf2; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; Article; comet assay; controlled study; DNA damage; Escherichia coli; kidney injury; mouse; neutrophil chemotaxis; nonhuman; priority journal; protein expression; renal protection; acute kidney failure; animal; Aralia; chemistry; disease model; drug effect; Escherichia coli; human; immunology; kidney; metabolism; oxidative stress; pathology | English | 2020 | 2020-03 | 10.1016/j.intimp.2020.106209 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Hispidulin alleviates imiquimod-induced psoriasis-like skin inflammation by inhibiting splenic Th1/Th17 cell population and keratinocyte activation | Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation and abnormal differentiation of epidermal keratinocytes accompanied by increased infiltration of immune cells. Previous studies have demonstrated that hispidulin (4',5,7-trihydroxy-6-methoxyflavone, HPD) has various pharmacological benefits such as anti-fungal, anti-inflammation, and anti-allergic effects. This study investigated the effectiveness of HPD to treat psoriasis using an imiquimod (IMQ)-induced mouse model and activated keratinocytes. IMQ was topically applied to the back skin of mice for six consecutive days, and the mice were orally administered HPD. Based on the histological observation and immunological analysis, oral administration of HPD suppressed psoriatic characteristics including skin thickness, psoriasis area severity index, transepidermal water loss, and neutrophil infiltration. HPD alleviated pathologically increased levels of immunoglobulin G2a, myeloperoxidase, and tumor necrosis factor-alpha. Splenic Th1 and Th17 cell populations were also reduced by HPD in the murine model. In addition, in activated keratinocytes, HPD inhibited gene expression of Th1- and Th17-associated cytokines and chemokines, and phosphorylation of mitogen-activated protein kinases and nuclear factor-kappa B. In summary, HPD alleviates psoriasis skin inflammation in vivo and in vitro. Therefore, we suggest that HPD would be a potent therapeutic candidate for the treatment of psoriasis. | Kim, Namkyung; Lee, Soyoung; Kang, Jinjoo; Choi, Young-Ae; Lee, Byungheon; Kwon, Taeg Kyu; Jang, Yong Hyun; Kim, Sang-Hyun | Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Pharmacol, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol, Immunoregulatory Mat Res Ctr, Jeongeup, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Immunol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu, South Korea | 57216981866; 8537269200; 57216977823; 7404777420; 16304374900; 7202206057; 57016046400; 57210450420 | yhjang@knu.ac.kr;shkim72@knu.ac.kr; | INTERNATIONAL IMMUNOPHARMACOLOGY | INT IMMUNOPHARMACOL | 1567-5769 | 1878-1705 | 87 | SCIE | IMMUNOLOGY;PHARMACOLOGY & PHARMACY | 2020 | 4.932 | 25.2 | 0.6 | 2025-06-25 | 18 | 19 | Hispidulin; Psoriasis; Imiquimod; Keratinocytes; Myeloperoxidase | T-CELLS; PATHOGENESIS; LESIONS; MICE | Hispidulin; Imiquimod; Keratinocytes; Myeloperoxidase; Psoriasis | Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Female; Flavones; Humans; Imiquimod; Keratinocytes; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Neutrophils; NF-kappa B; Psoriasis; Spleen; Th1 Cells; Th17 Cells; CXCL1 chemokine; hispidulin; immunoglobulin enhancer binding protein; immunoglobulin G2a; interleukin 17; interleukin 1beta; interleukin 6; mitogen activated protein kinase; myeloperoxidase; tumor necrosis factor; antiinflammatory agent; cytokine; flavone derivative; hispidulin; imiquimod; immunoglobulin enhancer binding protein; mitogen activated protein kinase; animal experiment; animal model; Article; controlled study; dry skin; erythema; erythrocyte; female; flow cytometry; HaCat cell line; human; human cell; imiquimod-induced psoriasis; immunohistochemistry; keratinocyte; mouse; neutrophil chemotaxis; nonhuman; priority journal; Psoriasis Area and Severity Index; real time polymerase chain reaction; skin water loss; skinfold thickness; spleen weight; Th1 cell; Th17 cell; animal; C57BL mouse; cell line; drug effect; immunology; keratinocyte; neutrophil; psoriasis; spleen; Th1 cell; Th17 cell | English | 2020 | 2020-10 | 10.1016/j.intimp.2020.106767 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The suppressive effect of dabrafenib, a therapeutic agent for metastatic melanoma, in IgE-mediated allergic inflammation | The functional inhibition of mast cells, which serve as a key effector cells in allergic reactions may be a specific target for treating immunoglobulin (Ig)E-mediated allergic reactions, which occur in various allergic diseases including anaphylaxis, asthma, and atopic dermatitis. In this study, we demonstrated the effects of dabrafenib, a therapeutic agent used to treat metastatic melanoma, with a focus on mast cell activation and local cutaneous anaphylaxis. In two types of mast cells (RBL-2H3 and mouse bone marrow-derived mast cells), dabrafenib (0.01, 0.1, 1 mu M) pretreatment significantly decreased IgE-induced degranulation, intracellular calcium influx, and the activity of intracellular signaling molecules, such as Lyn, Syk, Akt, and PLC gamma. Dabrafenib ameliorated mRNA and protein expression levels of interleukin-4 and tumor necrosis factor-alpha by the reduction of nuclear localization of nuclear factor-kappa B and nuclear factor of activated T-cells. In passive cutaneous anaphylaxis, oral administration of dabrafenib (0.1, 1, 10 mg/kg) reduced local pigmentation and ear thickness in a dose-dependent manner. Taken together, these results suggest that dabrafenib is a therapeutic drug candidate that controls IgE-mediated allergic inflammatory diseases through suppression of mast cell activity. | Choi, Young-Ae; Lee, Soyoung; Choi, Jin Kyeong; Kang, Byeong-Cheol; Kim, Min-Jong; Dhakal, Hima; Kwon, Taeg Kyu; Khang, Dongwoo; Kim, Sang-Hyun | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Cell & Matrix Res Inst, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol, Immunoregulatory Mat Res Ctr, Jeongeup, South Korea; NEI, Mol Immunol Sect, Lab Immunol, NIH, Bethesda, MD 20892 USA; Jeonbuk Natl Univ, Dept Immunol, Med Sch, Jeonju, South Korea; Keimyung Univ, Sch Med, Dept Immunol, Daegu, South Korea; Gachon Univ, Sch Med, Dept Physiol, 191 Hambangmoe Ro, Incheon, South Korea | 7404777420; 8537269200; 50261279600; 57192889562; 57192888932; 57195999763; 7202206057; 26039177500; 57210450420 | dkhang@gachon.ac.kr;shkim72@knu.ac.kr; | INTERNATIONAL IMMUNOPHARMACOLOGY | INT IMMUNOPHARMACOL | 1567-5769 | 1878-1705 | 83 | SCIE | IMMUNOLOGY;PHARMACOLOGY & PHARMACY | 2020 | 4.932 | 25.2 | 0.13 | 2025-06-25 | 5 | 3 | Dabrafenib; IgE-mediated allergic inflammation; Mast cells; Histamine; IL-4 | ROOIBOS ASPALATHUS-LINEARIS; MAST-CELLS; IN-VITRO; RAF KINASES; NOTHOFAGIN; INTERLEUKIN-4; CYTOKINES; CANCER; NFAT; IL-4 | Dabrafenib; Histamine; IgE-mediated allergic inflammation; IL-4; Mast cells | Anaphylaxis; Animals; Antineoplastic Agents; Calcium Signaling; Cell Degranulation; Disease Models, Animal; Humans; Imidazoles; Immunoglobulin E; Interleukin-4; Male; Mast Cells; Melanoma; Mice; Mice, Inbred ICR; Neoplasm Metastasis; NF-kappa B; Oximes; Skin; T-Lymphocytes; calcium; dabrafenib; dexamethasone; histamine; immunoglobulin E; interleukin 4; interleukin 6; messenger RNA; phospholipase C gamma; protein kinase B; protein kinase Lyn; protein kinase Syk; transcription factor NFAT; transcription factor RelA; tumor necrosis factor; antineoplastic agent; dabrafenib; imidazole derivative; immunoglobulin E; immunoglobulin enhancer binding protein; interleukin 4; oxime; allergy; animal cell; animal experiment; animal model; animal tissue; antiallergic activity; antiinflammatory activity; Article; calcium cell level; cell activation; controlled study; cytokine production; dose response; ear thickness; inflammation; intracellular signaling; male; mast cell; mast cell degranulation; metastatic melanoma; mouse; mRNA expression level; nonhuman; passive skin anaphylaxis; pigmentation; priority journal; protein expression level; RBL-2H3 cell line; transcription initiation; anaphylaxis; animal; calcium signaling; degranulation; disease model; drug effect; human; immunology; Institute for Cancer Research mouse; melanoma; metabolism; metastasis; pathology; skin; T lymphocyte | English | 2020 | 2020-06 | 10.1016/j.intimp.2020.106398 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Observation of in-plane magnetic field induced phase transitions in FeSe | We investigate thermodynamic properties of FeSe under in-plane magnetic fields using torque magnetometry, specific heat, and magnetocaloric measurements. Below the upper critical field H-c2, we observed the field induced anomalies at H-1 similar to 15 T and H-2 similar to 22 T near H parallel to ab and below a characteristic temperature T* similar to 2 K. The transition magnetic fields H-1 and H-2 exhibit negligible dependence on both temperature and field orientation. This contrasts to the strong temperature and angle dependence of H-c2, suggesting that these anomalies are attributed to the field induced phase transitions, originating from the inherent spin-density-wave instability of quasipaticles near the superconducting gap minima or possible Flude-Ferrell-Larkin-Ovchinnikov state in the highly spin-polarized Fermi surfaces. Our observations imply that FeSe, an atypical multiband superconductor with extremely small Fermi energies, represents a unique model system for stabilizing unusual superconducting orders beyond the Pauli limit. | Ok, Jong Mok; Kwon, Chang Il; Kohama, Yoshimitsu; You, Jung Sang; Park, Sun Kyu; Kim, Ji-hye; Jo, Y. J.; Choi, E. S.; Kindo, Koichi; Kang, Woun; Kim, Ki-Seok; Moon, E. G.; Gurevich, A.; Kim, Jun Sung | Pohang Univ Sci & Technol, Dept Phys, Pohang 37673, South Korea; Inst for Basic Sci Korea, Ctr Artificial Low Dimens Elect Syst, Pohang 37673, South Korea; Univ Tokyo, Inst Solid State Phys, Kashiwa, Chiba 2778581, Japan; Kyungpook Natl Univ, Dept Phys, Daegu 702701, South Korea; Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL 32310 USA; Ewha Womans Univ, Dept Phys, Seoul 03760, South Korea; Korea Adv Inst Sci & Technol, Dept Phys, Daejeon 34141, South Korea; Old Dominion Univ, Dept Phys, Norfolk, VA 23529 USA | Moon, Eun-Gook/G-5019-2015; Gurevich, Alex/A-4327-2008; Kim, Jun Sung/AAI-1673-2020; Kohama, Yoshimitsu/AAF-3281-2020 | 55744462900; 56468847000; 13004637000; 57117032600; 57191674417; 59089216600; 13502586500; 7402121894; 7006020484; 7202402145; 56097057300; 23036223400; 7102439758; 50061571500 | js.kim@postech.ac.kr; | PHYSICAL REVIEW B | PHYS REV B | 2469-9950 | 2469-9969 | 101 | 22 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2020 | 4.036 | 25.3 | 1.48 | 2025-06-25 | 23 | 23 | ELECTRON-SPIN; SUPERCONDUCTIVITY; TEMPERATURE; NEMATICITY; STATES; ORDER | Density (optical); Iron compounds; Iron-based Superconductors; Magnetic fields; Magnetometry; Selenium compounds; Specific heat; Spin density waves; Temperature; Characteristic temperature; Ferrell-Larkin-Ovchinnikov state; Field-induced phase transition; In-plane magnetic fields; Multi-band superconductors; Superconducting gaps; Superconducting orders; Upper critical fields; Phase transitions | English | 2020 | 2020-06-16 | 10.1103/physrevb.101.224509 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Universal properties of anyon braiding on one-dimensional wire networks | We demonstrate that anyons on wire networks have fundamentally different braiding properties than anyons in two dimensions (2D). Our analysis reveals an unexpectedly wide variety of possible non-Abelian braiding behaviors on networks. The character of braiding depends on the topological invariant called the connectedness of the network. As one of our most striking consequences, particles on modular networks can change their statistical properties when moving between different modules. However, sufficiently highly connected networks already reproduce the braiding properties of 2D systems. Our analysis is fully topological and independent on the physical model of anyons. | Maciazek, Tomasz; An, Byung Hee | Univ Bristol, Sch Math, Fry Bldg,Woodland Rd, Bristol BS8 1UG, Avon, England; Polish Acad Sci, Ctr Theoret Phys, Al Lotnikow 32-46, PL-02668 Warsaw, Poland; Kyungpook Natl Univ, Dept Math Educ, 80 Daehakro, Daegu 41566, South Korea | Maciążek, Tomasz/J-5893-2019; An, Byung Hee/O-8592-2014 | 55871881900; 36599927400 | kk19347@bristol.ac.uk; | PHYSICAL REVIEW B | PHYS REV B | 2469-9950 | 2469-9969 | 102 | 20 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2020 | 4.036 | 25.3 | 0.33 | 2025-06-25 | 6 | 5 | 2-D systems; Connected networks; Modular network; Physical model; Statistical properties; Topological invariants; Two dimensions (2D); Universal properties; Topology | English | 2020 | 2020-11-23 | 10.1103/physrevb.102.201407 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Effect of COD:N ratio on biological nitrogen removal using full-scale step-feed in municipal wastewater treatment plants | This study investigated the effect of low and high chemical oxygen demand (COD):N ratios on biological nitrogen removal and microbial distributions in full-scale step-feed (SF) municipal wastewater treatment plants (WWTPs) in Thailand (SF1) and Taiwan (SF2). The SF1WWTP had a low COD:N (4:1) ratio, a long solids retention time (SRT) (> 60 d), and low dissolved oxygen (DO) conditions (0.2 mg L(- 1)in anoxic tank and 0.9 mg L(- 1)in aerobic tank). The total nitrogen (TN) removal efficiency was 48%. The SF2WWTP had a high COD:N (10:1) ratio, a short SRT (7 d), and high DO (0.6 mg L(- 1)in anoxic tank and 1.8 mg L(- 1)in aerobic tank). The TN removal efficiency was 61%. The nitrification and denitrification rates from these two plants were inadequate. Using a quantitative polymerase chain reaction (qPCR) technique, the populations of ammonium oxidizing bacteria (AOB) and ammonium oxidizing archaea were quantified. Measurement of ammonia monooxygenase (amoA) gene abundances identified these AOB:Nitrosomonassp.,Nitrosospirasp.,Nitrosoccussp. andZoogloeasp. Higher amounts of the archaeal-amoAgene were found with long SRT, lower DO and COD:N ratios. Abundance ofNitrobactersp. was slightly higher thanNitrospirasp. at the SF1, while abundance ofNitrobactersp. was two orders of magnitude greater thanNitrospirasp. at the SF2. More denitrifying bacteria were of thenirS-type than thenirK-type, especially at higher COD:N ratio. Most bacteria belong to the phyla Acidobacteria, Actinobacteria Bacteroidetes, Chloroflexi, Proteobacteria. The results from this work showed that insufficient carbon sources at the SF(1)and high DO concentration in anoxic tank of SF(2)adversely affected nitrogen removal efficiencies. In further research work, advanced techniques on the next generation sequencing with different variable regions should be recommended in full-scale WWTPs. | Phanwilai, Supaporn; Noophan, Pongsak; Li, Chi-Wang; Choo, Kwang-Ho | Kasetsart Univ, Fac Engn, Dept Environm Engn, Bangkok 10900, Thailand; Tamkang Univ, Dept Water Resources & Environm Engn, New Taipei 25137, Taiwan; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Adv Inst Water Ind, Daegu 41566, South Korea | Li, Chi-Wang/G-1254-2015; Choo, Kwang-Ho/A-3456-2016 | 57193061180; 6506612491; 56621869300; 7102083272 | fengpsn@ku.ac.th; | SUSTAINABLE ENVIRONMENT RESEARCH | SUSTAIN ENVIRON RES | 2468-2039 | 30 | 1 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2020 | 4.98 | 25.4 | 0.89 | 2025-06-25 | 30 | 34 | Biological nitrogen removal; COD:N, Full-scale; Step-feed | AMMONIA-OXIDIZING BACTERIA; SIMULTANEOUS NITRIFICATION; ACTIVATED-SLUDGE; DENITRIFICATION; ARCHAEA; QUANTIFICATION; CRENARCHAEOTA; OXIDATION; ABUNDANCE; GENES | Biological nitrogen removal; COD:N; Full-scale; Step-feed | Ammonia; Bacteria; Biological water treatment; Chemical oxygen demand; Denitrification; Dissolved oxygen; Efficiency; Genes; Nitrogen removal; Polymerase chain reaction; Sewage pumping plants; Tanks (containers); Wastewater treatment; Water treatment plants; Ammonium oxidizing bacteria; Biological nitrogen removal; Microbial distribution; Municipal wastewater treatment plants; Next-generation sequencing; Nitrification and denitrification; Nitrogen removal efficiency; Quantitative polymerase chain reaction; Sewage treatment plants | English | 2020 | 2020-10-01 | 10.1186/s42834-020-00064-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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