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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Kidney ischemia/reperfusion injury causes cholangiocytes primary cilia disruption and abnormal bile secretion | Background: Acute kidney injury (AKI) causes distant liver injury, to date, which causes poor outcomes of patients with AKI. Many studies have been performed to overcome AKI-associated liver injury. However, those studies have mainly focused on hepatocytes, and AKI-induced liver injury still remains a clinical problem. Here, we investigated the implication of cholangiocytes and their primary cilia which are critical in final bile secretion. Cholangiocyte, a lining cell of bile ducts, are the only liver epithelial cell containing primary cilium (a microtubule-based cell surface signal-sensing organelle). Methods: Cystathione gamma-lyase (CSE, a transsulfuration enzyme) deficient and wild-type mice were subjected to kidney ischemia followed by reperfusion (KIR). Some mice were administered with N -acetyl-cysteine (NAC). Results: KIR damaged hepatocytes and cholagiocytes, disrupted cholangiocytes primary cilia, released the disrupted ciliary fragments into the bile, and caused abnormal bile secretion. Glutathione (GSH) and H 2 S levels in the livers were significantly reduced by KIR, resulting in increased the ratio oxidized GSH to total GSH, and oxidation of tissue and bile. CSE and cystathione ll-synthase (CBS) expression were lowered in the liver after KIR. NAC administration increased total GSH and H 2 S levels in the liver and attenuated KIR-induced liver injuries. In contrast, Cse deletion caused the reduction of total GSH levels and worsened KIR-induced liver injuries, including primary cilia damage and abnormal bile secretion. Conclusions: These results indicate that KIR causes cholangiocyte damage, cholangiocytes primary cilia disruption, and abnormal bile secretion through reduced antioxidative ability of the liver. | Han, Yong Kwon; Lim, Hui Jae; Jang, Gibong; Jang, Se Young; Park, Kwon Moo | Kyungpook Natl Univ, Sch Med, Dept Anat, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, 680 Gukchaebosangro, Daegu 41944, South Korea; Kyungpook Natl Univ, Grad Sch Med, Dept Biomed Sci, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Grad Sch Med, BK21 Plus, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 57226292650; 59116331800; 57260433300; 57202881977; 8785448200 | kmpark@knu.ac.kr; | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | BBA-MOL BASIS DIS | 0925-4439 | 1879-260X | 1870 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS | 2024 | 4.2 | 17.1 | 0.87 | 2025-05-07 | 2 | 2 | Acute kidney injury; Distant liver injury; Primary cilia; Cholangiocyte; Oxidative stress | CYSTATHIONINE GAMMA-LYASE; INDUCED FUNCTIONAL INJURY; MAPK KINASE ACTIVATION; RENAL ISCHEMIA/REPERFUSION; OXIDATIVE STRESS; N-ACETYLCYSTEINE; ISCHEMIA; ANTIOXIDANT; GLUTATHIONE; PREVENTION | Acute kidney injury; Cholangiocyte; Distant liver injury; Oxidative stress; Primary cilia | Acute Kidney Injury; Animals; Bile; Bile Ducts; Cilia; Cystathionine gamma-Lyase; Epithelial Cells; Glutathione; Hepatocytes; Hydrogen Sulfide; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Reperfusion Injury; 3 mercaptopyruvate sulfurtransferase; 4 hydroxynonenal; acetylcysteine; alanine aminotransferase; alkaline phosphatase; alpha tubulin; beta tubulin; cystathionine beta synthase; cystathionine gamma lyase; cytokeratin 7; glutathione; glutathione disulfide; glutathione reductase; hydrogen peroxide; hydrogen sulfide; malonaldehyde; nitrogen; phospholipid hydroperoxide glutathione peroxidase; reactive oxygen metabolite; urea; cystathionine gamma lyase; glutathione; hydrogen sulfide; alanine aminotransferase blood level; alkaline phosphatase blood level; animal experiment; animal model; animal tissue; Article; bile secretion; brush border; cell vacuole; cholangiocyte; controlled study; female; gallbladder; gene deletion; kidney injury; liver cell; liver injury; male; mouse; nonhuman; oxidative stress; primary cilium; protein expression; protein secretion; renal ischemia reperfusion injury; urea nitrogen blood level; acute kidney failure; animal; bile; bile duct; C57BL mouse; cilium; epithelium cell; genetics; kidney; knockout mouse; liver; metabolism; pathology; reperfusion injury | English | 2024 | 2024-08 | 10.1016/j.bbadis.2024.167225 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Nanoarchstructured MoS2-based strain sensor with exceptional gauge factor | Two-dimensional (2D) MoS2, part of the transition metal dichalcogenides family, has emerged as a promising candidate for wearable strain sensors owing to its unique attributes, including mechanical flexibility, low toxicity, tunable and high electrical properties. MoS2-based sensors exhibit higher gauge factors (similar to 760 for monocrystalline, similar to 56.5 for polycrystalline) and a lower limit of detection than conventional metal sensors. We report an advanced strain sensor with ultra-high sensitivity to minute deformations, exploiting a three-dimensional nanostructured-2D MoS2 (3DN-MoS2) with an arch-like configuration. The nanoarchstructured MoS2-based strain sensor (NaM-SS) achieves exceptional gauge factors, exceeding 1500 for tensile strain, using 3DN-MoS2 sensing material in conjunction with a poly-dimethylsiloxane support. This piezo-resistive sensor, fabricated through an eco-friendly and straightforward process, exhibits remarkable gauge factors at three levels: 1500 (epsilon < 0.55 %), 13,500 (0.55 %< epsilon <= 0.75 %), and 37,000 (0.75 % < epsilon <= 1.2 %). The sensor's limit of detection stands at a subtle tensile strain epsilon of 0.02 %. Furthermore, its feasibility is validated by its ability to monitor various human physical motions, including eye blinking, blood pulsation, and muscle activity. Our findings indicate significant potential for precision strain sensors in applications requiring ultra-high sensitivity, such as detecting subtle biomedical signals, meticulous machinery control, and structural health monitoring. | Park, Hyeji; Park, Jaeseo; Kang, Sang-Woo; Jeong, Soo-Hwan | Korea Res Inst Stand & Sci, Strateg Technol Res Inst, Daejeon 34113, South Korea; Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea; Univ Sci & Technol, Precis Measurement, Daejeon 34113, South Korea | , SooHwanJeong/JOJ-6732-2023 | 57193897897; 57193167941; 13607652400; 7402425359 | swkang@kriss.re.kr;shjeong@knu.ac.kr; | SENSORS AND ACTUATORS A-PHYSICAL | SENSOR ACTUAT A-PHYS | 0924-4247 | 1873-3069 | 380 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION | 2024 | 4.9 | 17.1 | 0.38 | 2025-05-07 | 1 | 1 | Nanostructure; Transition metal dichalcogenides; Strain sensor; Gauge factor; Sensitivity | LAYER MOS2; FILMS; ARRAYS; SUBTLE | Gauge factor; Nanostructure; Sensitivity; Strain sensor; Transition metal dichalcogenides | Gage factors; Low-high; Mechanical flexibility; MoS 2; Nano-structured; Sensitivity; Strain sensors; Transition metal dichalcogenides (TMD); Two-dimensional; Ultra-high-sensitivity; Strain gages | English | 2024 | 2024-12-16 | 10.1016/j.sna.2024.116050 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Prognostic effect of microscopically negative but close resection margin in gastric cancer | Introduction: Microscopically positive resection margin (RM) following curative surgery has been linked to disease recurrence in gastric cancer (GC), but the impact of microscopically negative but close RM (CRM) remains unclear. This study aimed to evaluate the prognostic implications of a CRM of 0.5 cm) groups. The impact of CRM on recurrence-free survival (RFS) and overall survival (OS) was analyzed compared to the SRM group. Results: The cohort comprised 1264 patients with early GC (EGC, 64.6%) and 694 with advanced GC (AGC, 35.4%). Forty-four patients (2.2%) had RM of <= 0.5 cm. CRM was associated with worse RFS in AGC (5-year RFS in the CRM vs. SRM groups; 41.6% vs. 68.7%, p = 0.011); however, the effect on OS was not significant (p = 0.159). Multivariate analysis revealed that CRM was an independent prognostic factor for RFS (hazard ratio [HR] 2.035, 95% confidence interval [CI] 1.097-3.776). In AGC, the locoregional recurrence rate was significantly higher in the CRM group than in the SRM group (15.4% vs. 4.9%, p = 0.044). Conclusion: CRM of <= 0.5 cm was a significant prognostic factor for RFS in GC patients and was associated with a significant increase in locoregional recurrence in AGC. | Park, Ji Yeon; Yang, Jae Yeong; Park, Ki Bum; Kwon, Oh Kyoung; Lee, Seung Soo; Chung, Ho Young | Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Dept Surg, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Surg, Daegu, South Korea | ; Park, Ji Yeon/AAV-2471-2020 | 57196405216; 58983956400; 57220965452; 26536109900; 54400392100; 56008255800 | jybark99@knu.ac.kr; | EJSO | EJSO-EUR J SURG ONC | 0748-7983 | 1532-2157 | 50 | 9 | SCIE | ONCOLOGY;SURGERY | 2024 | 2.9 | 17.1 | 1.52 | 2025-05-07 | 2 | 2 | Margins of excision; Stomach neoplasms; Survival rate; Survival analysis; Recurrence | CURATIVE RESECTIONS; PROXIMAL RESECTION; LINE INVOLVEMENT; RECURRENCE; DISTANCE; ADENOCARCINOMA; GASTRECTOMY; IMPACT | Margins of excision; Recurrence; Stomach neoplasms; Survival analysis; Survival rate | Adenocarcinoma; Adult; Aged; Disease-Free Survival; Female; Gastrectomy; Humans; Male; Margins of Excision; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Retrospective Studies; Stomach Neoplasms; Survival Rate; antineoplastic agent; adjuvant chemotherapy; adult; age; Article; body mass; cancer prognosis; clinical feature; cohort analysis; comparative study; female; follow up; gastrectomy; human; major clinical study; male; middle aged; overall survival; prospective study; radical gastrectomy; recurrence free survival; recurrence risk; retrospective study; stomach cancer; surgical margin; tumor volume; adenocarcinoma; aged; cancer staging; disease free survival; gastrectomy; mortality; pathology; prognosis; stomach tumor; surgery; survival rate; tumor recurrence | English | 2024 | 2024-09 | 10.1016/j.ejso.2024.108517 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Letter | Reevaluating surgical margins in gastric cancer: Addressing the impact of close resection margins and BMI classification on prognosis | Park, Ji Yeon; Park, Ki Bum; Kwon, Oh Kyoung | Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Surg, 807 Hoguk Ro, Daegu 41404, South Korea | Park, Ji Yeon/AAV-2471-2020 | 57196405216; 57220965452; 26536109900 | jybark990118@naver.com;jybark99@knu.ac.kr; | EJSO | EJSO-EUR J SURG ONC | 0748-7983 | 1532-2157 | 50 | 10 | SCIE | ONCOLOGY;SURGERY | 2024 | 2.9 | 17.1 | 0 | 2025-05-07 | 0 | 0 | Body Mass Index; Gastrectomy; Humans; Margins of Excision; Prognosis; Stomach Neoplasms; age; body mass; body weight; cancer prognosis; cancer staging; cancer surgery; clinical outcome; comorbidity; gastrectomy; human; ideal body weight; independent variable; Letter; obese patient; obesity; overall survival; perioperative complication; postoperative complication; recurrence free survival; risk factor; sex; stomach cancer; surgical risk; tumor-close margin; underweight; gastrectomy; pathology; procedures; prognosis; stomach tumor; surgery; surgical margin | English | 2024 | 2024-10 | 10.1016/j.ejso.2024.108575 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Biocatalytic degradation of environmental endocrine disruptor chlorobenzene via surfactant-optimized laccase-mediator system | The emergence of environmental endocrine disruptor chlorobenzene (CB) in surface water and its potential environmental impacts have attracted serious global attention. It is still very difficult to achieve effective degradation of it by catalytic oxidation process under mild conditions. Here, an optimized method for degrading CB in aqueous solution using Trametes versicolor laccase and surfactant-assisted laccase-mediator (SALM) system was investigated. The use of a Tween 80 surfactant enhanced the solubility of CB and promoted its efficient degradation. Under favorable conditions, the SALM system yielded a degradation efficiency of 43.5% and a dechlorination efficiency of 41.55% for CB (25 mg/L) within 24 h. The possible degradation pathway of CB by this system was speculated by detecting the intermediates produced during the reaction. The outcome of the proliferation assays on MCF-7 human breast cancer cells demonstrated a reduction in the estrogenic activity of the CB solution following treatment with the SALM system. Furthermore, the influence of the quantity and positional variation of chlorine substituents on the degradation process was methodically investigated. Moreover, molecular analyses were employed to study the detailed interaction mechanism between laccase and CB, which revealed that the hydrophobic interaction contributed dominantly to binding process. These findings provide an efficient and environmentally friendly degradation system for the development of purification strategies for halogenated pollutants. | Wang, Dan; Huang, Guifang; Yu, Chunming; Wang, Yawen; Baek, Nawon; Zhu, Ruofei | Xinjiang Univ, Coll Text & Clothing, Urumqi, Peoples R China; Xinjiang Univ, Xinjiang Key Lab Intelligent & Green Text, Urumqi, Peoples R China; Kyungpook Natl Univ, Dept Clothing & Text, Daegu, South Korea; Kyungpook Natl Univ, Ctr Beautiful Aging, Daegu, South Korea | 57219834668; 59385157400; 59384390900; 59385005500; 57223872666; 57216312396 | ffwd@xju.edu.cn;ruofeizhu@xju.edu.cn; | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | FRONT BIOENG BIOTECH | 2296-4185 | 12 | SCIE | ENGINEERING, BIOMEDICAL;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 4.8 | 17.2 | 0 | 2025-05-07 | 0 | 1 | laccase; chlorobenzenes; degradation; estrogenic activity; molecular simulation | ASSISTED DEGRADATION; ENZYMATIC TREATMENT; REMOVAL; CONTAMINANTS; PEROXIDASES; RESIDUES; CARBON | chlorobenzenes; degradation; estrogenic activity; laccase; molecular simulation | Biodegradation; Dechlorination; Degradation; Endocrine disrupters; Chlorobenzene; Condition; Environmental endocrine disruptors; Estrogenic activities; Laccase/mediator systems; Laccases; Molecular simulations; Oxidation process; Surfactant assisted; Trametes versicolor laccase; Catalytic oxidation | English | 2024 | 2024-10-14 | 10.3389/fbioe.2024.1469029 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Challenges of COVID-19 Case Forecasting in the US, 2020-2021 | During the COVID-19 pandemic, forecasting COVID-19 trends to support planning and response was a priority for scientists and decision makers alike. In the United States, COVID-19 forecasting was coordinated by a large group of universities, companies, and government entities led by the Centers for Disease Control and Prevention and the US COVID-19 Forecast Hub (https://covid19forecasthub.org). We evaluated approximately 9.7 million forecasts of weekly state-level COVID-19 cases for predictions 1-4 weeks into the future submitted by 24 teams from August 2020 to December 2021. We assessed coverage of central prediction intervals and weighted interval scores (WIS), adjusting for missing forecasts relative to a baseline forecast, and used a Gaussian generalized estimating equation (GEE) model to evaluate differences in skill across epidemic phases that were defined by the effective reproduction number. Overall, we found high variation in skill across individual models, with ensemble-based forecasts outperforming other approaches. Forecast skill relative to the baseline was generally higher for larger jurisdictions (e.g., states compared to counties). Over time, forecasts generally performed worst in periods of rapid changes in reported cases (either in increasing or decreasing epidemic phases) with 95% prediction interval coverage dropping below 50% during the growth phases of the winter 2020, Delta, and Omicron waves. Ideally, case forecasts could serve as a leading indicator of changes in transmission dynamics. However, while most COVID-19 case forecasts outperformed a na & iuml;ve baseline model, even the most accurate case forecasts were unreliable in key phases. Further research could improve forecasts of leading indicators, like COVID-19 cases, by leveraging additional real-time data, addressing performance across phases, improving the characterization of forecast confidence, and ensuring that forecasts were coherent across spatial scales. In the meantime, it is critical for forecast users to appreciate current limitations and use a broad set of indicators to inform pandemic-related decision making. As SARS-CoV-2 began to spread throughout the world in early 2020, modelers played a critical role in predicting how the epidemic could take shape. Short-term forecasts of epidemic outcomes (for example, infections, cases, hospitalizations, or deaths) provided useful information to support pandemic planning, resource allocation, and intervention. Yet, infectious disease forecasting is still a nascent science, and the reliability of different types of forecasts is unclear. We retrospectively evaluated COVID-19 case forecasts, which were often unreliable. For example, forecasts did not anticipate the speed of increase in cases in early winter 2020. This analysis provides insights on specific problems that could be addressed in future research to improve forecasts and their use. Identifying the strengths and weaknesses of forecasts is critical to improving forecasting for current and future public health responses. | Lopez, Velma K.; Cramer, Estee Y.; Pagano, Robert; Drake, John M.; O'Dea, Eamon B.; Adee, Madeline; Ayer, Turgay; Chhatwal, Jagpreet; Dalgic, Ozden O.; Ladd, Mary A.; Linas, Benjamin P.; Mueller, Peter P.; Xiao, Jade; Bracher, Johannes; Castro Rivadeneira, Alvaro J.; Gerding, Aaron; Gneiting, Tilmann; Huang, Yuxin; Jayawardena, Dasuni; Kanji, Abdul H.; Le, Khoa; Muehlemann, Anja; Niemi, Jarad; Ray, Evan L.; Stark, Ariane; Wang, Yijin; Wattanachit, Nutcha; Zorn, Martha W.; Pei, Sen; Shaman, Jeffrey; Yamana, Teresa K.; Tarasewicz, Samuel R.; Wilson, Daniel J.; Baccam, Sid; Gurung, Heidi; Stage, Steve; Suchoski, Brad; Gao, Lei; Gu, Zhiling; Kim, Myungjin; Li, Xinyi; Wang, Guannan; Wang, Lily; Wang, Yueying; Yu, Shan; Gardner, Lauren; Jindal, Sonia; Marshall, Maximilian; Nixon, Kristen; Dent, Juan; Hill, Alison L.; Kaminsky, Joshua; Lee, Elizabeth C.; Lemaitre, Joseph C.; Lessler, Justin; Smith, Claire P.; Truelove, Shaun; Kinsey, Matt; Mullany, Luke C.; Rainwater-Lovett, Kaitlin; Shin, Lauren; Tallaksen, Katharine; Wilson, Shelby; Karlen, Dean; Castro, Lauren; Fairchild, Geoffrey; Michaud, Isaac; Osthus, Dave; Bian, Jiang; Cao, Wei; Gao, Zhifeng; Lavista Ferres, Juan; Li, Chaozhuo; Liu, Tie-Yan; Xie, Xing; Zhang, Shun; Zheng, Shun; Chinazzi, Matteo; Davis, Jessica T.; Mu, Kunpeng; Piontti, Ana; Vespignani, Alessandro; Xiong, Xinyue; Walraven, Robert; Chen, Jinghui; Gu, Quanquan; Wang, Lingxiao; Xu, Pan; Zhang, Weitong; Zou, Difan; Gibson, Graham Casey; Sheldon, Daniel; Srivastava, Ajitesh; Adiga, Aniruddha; Hurt, Benjamin; Kaur, Gursharn; Lewis, Bryan; Marathe, Madhav; Peddireddy, Akhil Sai; Porebski, Przemyslaw; Venkatramanan, Srinivasan; Wang, Lijing; Prasad, Pragati V.; Walker, Jo W.; Webber, Alexander E.; Slayton, Rachel B.; Biggerstaff, Matthew; Reich, Nicholas G.; Johansson, Michael A. | CDCP, COVID 19 Response, Atlanta, GA 30333 USA; Univ Massachusetts, Amherst, MA USA; Univ Georgia, Athens, GA USA; Massachusetts Gen Hosp, Boston, MA USA; Georgia Inst Technol, Atlanta, GA USA; Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA USA; Value Analyt Labs, Boston, MA USA; Boston Univ, Sch Med, Boston, MA USA; Karlsruhe Inst Technol, Chair Econometr & Stat, Karlsruhe, Germany; Heidelberg Inst Theoret Studies, Heidelberg, Germany; Univ Bern, Inst Math Stat & Actuarial Sci, Bern, Switzerland; Iowa State Univ, Ames, IA USA; Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA; Fed Reserve Bank San Francisco, San Francisco, CA USA; IEM, Bel Air, MD USA; IEM, Baton Rouge, LA USA; George Mason Univ, Fairfax, VA USA; Kyungpook Natl Univ, Daegu, South Korea; Clemson Univ, Clemson, SC USA; Coll William & Mary, Williamsburg, VA USA; Amazon, Seattle, WA USA; Univ Virginia, Charlottesville, VA USA; Johns Hopkins Univ, Baltimore, MD USA; Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA; Ecole Polytech Fed Lausanne, Lausanne, Switzerland; Univ North Carolina Chapel Hill, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA; Johns Hopkins Univ, Appl Phys Lab, Baltimore, MD USA; Univ Victoria, Victoria, BC, Canada; TRIUMF, Victoria, BC, Canada; Los Alamos Natl Lab, Los Alamos, NM USA; Microsoft, Redmond, WA USA; Northeastern Univ, Lab Modeling Biol & Sociotech Syst, Boston, MA USA; Univ Calif Los Angeles, Los Angeles, CA USA; Univ Southern Calif, Los Angeles, CA USA; Discreet Labs, Raleigh, NC USA; New Jersey Inst Technol, Newark, NJ USA | Gao, Zhifeng/AFD-7759-2022; Reich, Nicholas/L-1168-2019; Srivastava, Ajitesh/AAQ-9555-2020; Gao, Lei/I-4159-2013; Zhang, Weitong/AHA-3224-2022; li, xinyi/GWZ-8941-2022; li, zhiwen/C-4675-2011; Xiao, Jade/KPB-0427-2024; Chen, Jinghui/NQE-7634-2025; Gneiting, Tilmann/A-8773-2009; Truelove, Shaun/D-4187-2018; Pei, Sen/AAN-8662-2020; Yamana, Teresa/GNM-7684-2022; Chinazzi, Matteo/HNI-9615-2023; Lewis, Bryan/LMN-4955-2024; Drake, John/D-6622-2012; Lee, Elizabeth/H-6508-2019; Xu, Pan/AAH-3620-2019; Biggerstaff, Matthew/I-5732-2013; Porebski, Przemyslaw/D-9661-2018; CHEN, Wei/KNT-1323-2024; O'Dea, Eamon/E-6389-2016; GU, Zhiling/LTF-1692-2024 | 57104552900; 57204097950; 57222341674; 7201816666; 36247444500; 57202117794; 35797984500; 57203030161; 56121042800; 57204535488; 6506942815; 57216593525; 57238151300; 56732858200; 57222345245; 57222338771; 7003342687; 57222338689; 57222343555; 57221696769; 57219752492; 57219507419; 7005390035; 57199156250; 57222340455; 57221697227; 57219588923; 57210090989; 42161940400; 57203074277; 8259512200; 58492556100; 55478300700; 58492556200; 57237796700; 57237798600; 55523582200; 56680448000; 57219629332; 57216929620; 58679664800; 56233720800; 59650462200; 57211862267; 57211676575; 36109794700; 57702566800; 59579140500; 57237969000; 57223457666; 36655661800; 57209229166; 57030957100; 57202393899; 22951309100; 57223453978; 56549664600; 57216337696; 6602908826; 16686795300; 57223457773; 57222344113; 57223456053; 14067325700; 7202228750; 55949067700; 54416124000; 56038012200; 59368334000; 57225815341; 57238843500; 57208244216; 57237970900; 57239022200; 57238149000; 57238494300; 57199261878; 36760546800; 57215716183; 57216352522; 57272315500; 7004546582; 57204895349; 57221687636; 57218847493; 56020748300; 57202467714; 57192236782; 57219694396; 56513235800; 57212152190; 23398451200; 38862842800; 36447297900; 57223309476; 57204910792; 35617044100; 7005103606; 57221151145; 39262249400; 57078694800; 57195471168; 57219557058; 57221686857; 58491586000; 55337092600; 16314774100; 57831368600; 16233749100 | oko8@cdc.gov; | PLOS COMPUTATIONAL BIOLOGY | PLOS COMPUT BIOL | 1553-734X | 1553-7358 | 20 | 5 | SCIE | BIOCHEMICAL RESEARCH METHODS;MATHEMATICAL & COMPUTATIONAL BIOLOGY | 2024 | 3.6 | 17.2 | 3.06 | 2025-05-07 | 8 | 8 | HUMAN-BEHAVIOR | Computational Biology; COVID-19; Forecasting; Humans; Models, Statistical; Pandemics; SARS-CoV-2; United States; Cell proliferation; Decision making; Disease control; Forecasting; rain; Centres for disease control and preventions; Decision makers; Entity-led; Gaussians; Generalized estimating equations; Government entities; Large groups; Leading indicators; Prediction interval; Weighted intervals; accuracy; algorithm; Article; coronavirus disease 2019; decision making; disease transmission; epidemic; forecasting; human; incidence; outcome assessment; pandemic; seasonal variation; sensitivity analysis; time series analysis; trend study; United States; bioinformatics; coronavirus disease 2019; pandemic; procedures; Severe acute respiratory syndrome coronavirus 2; statistical model; COVID-19 | English | 2024 | 2024-05 | 10.1371/journal.pcbi.1011200 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Comparison of endoscopic healing and durability between infliximab originator and CT-P13 in pediatric patients with inflammatory bowel disease | Background and aims: Favourable clinical data were published on the efficacy of CT-P13, the first biosimilar of infliximab (IFX), in pediatric inflammatory bowel disease (IBD); however, few studies have compared the effect on endoscopic healing (EH) and drug retention rate between the IFX originator and CT-P13. Therefore, we aimed to compare EH and the drug retention rate between the IFX originator and CT-P13. Methods: Children with Crohn's disease (CD) and ulcerative colitis (UC)/IBD-unclassified (IBD-U) at 22 medical centers were enrolled, with a retrospective review conducted at 1-year and last follow-up. Clinical remission, EH and drug retention rate were evaluated. Results: We studied 416 pediatric patients with IBD: 77.4% had CD and 22.6% had UC/IBD-U. Among them, 255 (61.3%) received the IFX originator and 161 (38.7%) received CT-P13. No statistically significant differences were found between the IFX originator and CT-P13 in terms of corticosteroid-free remission and adverse events. At 1-year follow-up, EH rates were comparable between them (CD: P=0.902, UC: P=0.860). The estimated cumulative cessation rates were not significantly different between the two groups. In patients with CD, the drug retention rates were 66.1% in the IFX originator and 71.6% in the CT-P13 group at the maximum follow-up period (P >0.05). In patients with UC, the drug retention rates were 49.8% in the IFX originator and 56.3% in the CT-P13 group at the maximum follow-up period (P >0.05). Conclusions: The IFX originator and CT-P13 demonstrated comparable therapeutic response including EH, clinical remission, drug retention rate and safety in pediatric IBD. | Kim, Eun Sil; Choi, Sujin; Choe, Byung-Ho; Park, Sowon; Lee, Yeoun Joo; Sohn, Sang Jun; Kim, Soon Chul; Kang, Ki Soo; Lee, Kunsong; Shim, Jung Ok; Kim, Yu Bin; Hong, Suk Jin; Lee, Yoo Min; Kim, Hyun Jin; Choi, So Yoon; Kim, Ju Young; Lee, Yoon; Park, Ji-Sook; Kim, Jae Young; Yi, Dae Yong; Lee, Ji Hyuk; Choi, Kwang-Hae; Jang, Hyo-Jeong; Jeong, In Sook; Kang, Ben | Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Pediat, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Crohns & Colitis Assoc Daegu Gyeongbuk CCAiD, Daegu, South Korea; Yonsei Univ, Severance Childrens Hosp, Coll Med, Div Gastroenterol Hepatol & Nutr,Dept Pediat, Seoul, South Korea; Pusan Natl Univ, Sch Med, Pusan Natl Univ Childrens Hosp, Dept Pediat, Yangsan, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Dept Pediat, Med Sch, Jeonju, South Korea; Jeju Natl Univ Hosp, Dept Pediat, Jeju, South Korea; Dankook Univ, Coll Med, Dept Pediat, Cheonan, South Korea; Korea Univ, Coll Med, Guro Hosp, Dept Pediat, Seoul, South Korea; Ajou Univ, Sch Med, Dept Pediat, Suwon, South Korea; Daegu Catholic Univ, Dept Pediat, Sch Med, Daegu, South Korea; Soonchunhyang Univ, Coll Med, Soonchunhyang Univ Bucheon Hosp, Dept Pediat, Bucheon, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Dept Pediat, Coll Med, Daejeon, South Korea; Kosin Univ, Kosin Univ Gospel Hosp, Dept Pediat, Coll Med, Busan, South Korea; Eulji Univ, Daejeon Eulji Med Ctr, Dept Pediat, Daejeon, South Korea; Korea Univ, Dept Pediat, Med Ctr, Anam Hosp, Seoul, South Korea; Gyeongsang Natl Univ, Coll Med, Dept Pediat, Jinju, South Korea; Gyeongsang Natl Univ, Inst Med Sci, Jinju, South Korea; Gyeongsang Natl Univ, Dept Pediat, Changwon Hosp, Chang Won, South Korea; Chung Ang Univ, Coll Med, Dept Pediat, Chung Ang Univ Hosp, Seoul, South Korea; Chungbuk Natl Univ, Coll Med, Dept Pediat, Chungju, South Korea; Yeungnam Univ, Dept Pediat, Sch Med, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Pediat, Daegu, South Korea; Chung Ang Univ, Gwangmyeong Hosp, Dept Pediat, Gwangmyeong, South Korea | Lee, Jason/M-7522-2016; Kim, Youngmin/C-7926-2019; Choe, Byung-Ho/KSM-6251-2024; 康, 奔/JMQ-0812-2023; Kim, Siwon/KHX-9078-2024; Lee, KyungJae/MIO-6255-2025; Kim, Nam-Joong/J-2735-2012; Lee, Ji Min/ABE-7494-2021; Yi, Dae/G-1729-2014; Lee, Yeoun Joo/AGP-1813-2022 | 57205500267; 57223972405; 57574977300; 57020161000; 34877162300; 58748811200; 36087407700; 56892514000; 55911172700; 57022898300; 57212382905; 56573097000; 55588928200; 58975661600; 57207282105; 57202996384; 55588945800; 35485228600; 57203251636; 57190851975; 36011672600; 55040976900; 55355948500; 57193896536; 57194823199 | benkang@knu.ac.kr; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 15 | SCIE | IMMUNOLOGY | 2024 | 5.9 | 17.2 | 0 | 2025-04-16 | 1 | 0 | children; inflammatory bowel disease; CT-P13; endoscopic healing; durability | NECROSIS FACTOR-ALPHA; CROHNS-DISEASE; DOUBLE-BLIND; BIOSIMILAR INFLIXIMAB; INNOVATOR INFLIXIMAB; MEDICAL-MANAGEMENT; PARALLEL-GROUP; CHILDREN; THERAPY; EFFICACY | children; CT-P13; durability; endoscopic healing; inflammatory bowel disease | Antibodies, Monoclonal; Child; Colitis, Ulcerative; Crohn Disease; Humans; Inflammatory Bowel Diseases; Infliximab; Treatment Outcome; biosimilar agent; corticosteroid; CT-P13; hemoglobin; infliximab; unclassified drug; CT-P13; infliximab; monoclonal antibody; adolescent; Article; child; Crohn disease; Crohn Disease Activity Index; drug retention; drug withdrawal; endoscopic healing; endoscopy; female; follow up; gastrointestinal hemorrhage; hospitalization; human; inflammatory bowel disease; Kaplan Meier method; leukocyte count; major clinical study; male; multicenter study; observational study; platelet count; retrospective study; Simple Endoscopic Score for Crohn Disease; ulcerative colitis; Crohn disease; treatment outcome; ulcerative colitis | English | 2024 | 2024-02-22 | 10.3389/fimmu.2024.1284181 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Editorial Material | Editorial: Single-cell analysis on the pathophysiology of autoimmune diseases | Tzeng, Shiang-Jong; Kim, Inkyeom; Sun, Kuang-Hui | Natl Taiwan Univ, Grad Inst Pharmacol, Coll Med, Taipei, Taiwan; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu, South Korea; Kyungpook Natl Univ, BK21 Plus, Sch Med, Biomed Convergence Program, Daegu, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Sch Med, Daegu, South Korea; Natl Yang Ming Chiao Tung Univ, Dept Biotechnol, Taipei, Taiwan; Natl Yang Ming Chiao Tung Univ, Lab Sci Med, Taipei, Taiwan | Sun, Kuang-Hui/A-4511-2012; Tzeng, Shiang-Jong/AED-3885-2022 | 8061289500; 7404144630; 7401518685 | sjtzeng@ntu.edu.tw;inkim@knu.ac.kr;khsun@nycu.edu.tw; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 15 | SCIE | IMMUNOLOGY | 2024 | 5.9 | 17.2 | 2.19 | 2025-05-07 | 2 | 2 | autoimmune disease; single-cell RNA sequencing (scRNA-seq); transcriptomics; epigenomics; mass cytometry; CITE-seq; pathophysiology; therapy | autoimmune disease; CITE-seq; epigenomics; mass cytometry; pathophysiology; single-cell RNA sequencing (scRNA-seq); therapy; transcriptomics | Animals; Autoimmune Diseases; Humans; Single-Cell Analysis; cathepsin L; high mobility group B1 protein; interferon regulatory factor 7; interleukin 8; toll like receptor 4; transcriptome; transforming growth factor beta; vasculotropin; autoimmune disease; CITE sequence; CRISPR-CAS9 system; disease severity; drug therapy; Editorial; epigenetics; gene editing; gene expression; gene sequence; gene silencing; hematopoietic stem cell; human; hypertension; immune response; immunohistochemistry; inflammation; lamina propria; lupus erythematosus nephritis; mass cytometry; natural killer cell; pathophysiology; personalized medicine; progenitor cell line; protein protein interaction; psoriasis; regulatory B lymphocyte; rheumatoid arthritis; RNA sequence; single cell analysis; single cell RNA seq; systemic lupus erythematosus; systemic sclerosis; transcriptomics; upregulation; vaccination; animal; immunology; procedures | English | 2024 | 2024-07-02 | 10.3389/fimmu.2024.1451354 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Estimates of vaccine effectiveness of the updated monovalent XBB.1.5 COVID-19 vaccine against symptomatic SARS-CoV-2 infection, hospitalization, and receipt of oxygen therapy in South Korea - October 26 to December 31, 2023 | Objectives: We evaluated the vaccine effectiveness of monovalent XBB.1.5 vaccine against symptomatic COVID-19 infection, hospitalization, and the need for oxygen therapy in South Korea. Design: This study employed a test-negative case-control design. COVID-19 test results in symptomatic subjects from six university hospitals across South Korea were collected (October 26-December 31, 2023). The adjusted absolute and relative vaccine effectiveness were assessed. Results: In total, 5516 subjects were enrolled: 4,824 were unvaccinated with XBB.1.5, and 692 were vaccinated with XBB.1.5 COVID-19 mRNA vaccines. The absolute vaccine effectiveness when comparing the odds between XBB.1.5 vaccination and no vaccination against symptomatic COVID-19 infection, hospitalization, and oxygen therapy was 65.2% (95% CI, 36.1-81.0), 77.3% (95% CI, 51.1-89.5), and 85.3% (95% CI, 57.8-94.9), respectively. The relative vaccine effectiveness when comparing the odds between XBB.1.5 vaccination and no XBB.1.5 vaccination against symptomatic COVID-19 infection, hospitalization, and oxygen therapy was 57.7% (95% CI, 34.7-72.6), 64.3% (95% CI, 35.9-80.2), and 65.5% (95% CI, 27.0-83.7), respectively. Conclusion: The short-term effectiveness of the XBB.1.5 vaccine against symptomatic COVID-19 infection, hospitalization, and receipt of oxygen therapy in South Korea was significant. Long-term vaccine effectiveness warrants evaluation, and these assessments should be conducted regularly. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) | Lee, Jung Ah; Jang, Heeseon; Ahn, Sang Min; Seong, Jae Eun; Kim, Young Keun; Sohn, Yujin; Jung, Sook In; Jeong, Hye Won; Kim, Shin-Woo; Lee, Jin-Soo; Baek, Ji-Hyeon; Lee, Se Ju; Kwon, Geun-Yong; Shin, Jeeyeon; Jeong, Hangjin; Kim, Changsoo; Choi, Jun Yong | Yonsei Univ, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea; Chonnam Natl Univ, Med Sch, Dept Infect Dis, Gwangju, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Inha Univ, Coll Med, Dept Internal Med, Div Infect Dis, Incheon, South Korea; Korea Dis Control & Prevent Agcy, Div Immunizat, Cheongju, South Korea | LEE, SEJUE/KMX-1267-2024; Kim, Young Hoon/F-5424-2012; Jeong, Hye/AET-1982-2022; JUNG, SOOK IN/AGO-2862-2022; Choi, Jun/AEH-4018-2022 | 57432722000; 57212674364; 57217106968; 59232954200; 35322538300; 57216369805; 7403676835; 13103042700; 8710731500; 56162297100; 26644740900; 57192094225; 55313197100; 57822280200; 55834988300; 56192768900; 57791298700 | seran@yuhs.ac; | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | INT J INFECT DIS | 1201-9712 | 1878-3511 | 148 | SCIE | INFECTIOUS DISEASES | 2024 | 4.3 | 17.2 | 0.65 | 2025-05-07 | 3 | 3 | COVID-19; Vaccine; Vaccine effectiveness; XBB.1.5 | COVID-19-ASSOCIATED HOSPITALIZATION; IMMUNOCOMPETENT ADULTS; OMICRON VARIANT; UNITED-STATES; NETWORK | COVID-19; Vaccine; Vaccine effectiveness; XBB.1.5 | Adult; Aged; Case-Control Studies; COVID-19; COVID-19 Vaccines; Female; Hospitalization; Humans; Male; Middle Aged; Oxygen Inhalation Therapy; Republic of Korea; SARS-CoV-2; Vaccination; Vaccine Efficacy; Young Adult; oxygen; SARS-CoV-2 vaccine; vaccine; adult; aged; Article; case control study; chronic lung disease; controlled study; coronavirus disease 2019; drug efficacy; evaluation study; female; hematologic malignancy; hospitalization; human; major clinical study; male; oxygen therapy; population based case control study; retrospective study; SARS-CoV-2 (lineage XBB.1.5); South Korea; university hospital; unvaccinated person; vaccination; vaccinee; coronavirus disease 2019; epidemiology; immunology; middle aged; prevention and control; Severe acute respiratory syndrome coronavirus 2; South Korea; therapy; vaccination; young adult | English | 2024 | 2024-11 | 10.1016/j.ijid.2024.107249 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Exosomal noncoding RNA: A potential therapy for retinal vascular diseases | Exosomes are extracellular vesicles that can contain DNA, RNA, proteins, and metabolites. They are secreted by cells and play a regulatory role in various biological responses by mediating cell-to-cell communication. Moreover, exosomes are of interest in developing therapies for retinal vascular disorders because they can deliver various substances to cellular targets. According to recent research, exosomes can be used as a strategy for managing retinal vascular diseases, and they are being investigated for therapeutic purposes in eye conditions, including glaucoma, dry eye syndrome, retinal ischemia, diabetic retinopathy, and age-related macular degeneration. However, the role of exosomal noncoding RNA in retinal vascular diseases is not fully understood. Here, we reviewed the latest research on the biological role of exosomal noncoding RNA in treating retinal vascular diseases. Research has shown that noncoding RNAs, including microRNAs, circular RNAs, and long noncoding RNAs play a significant role in the regulation of retinal vascular diseases. Furthermore, through exosome engineering, the expression of relevant noncoding RNAs in exosomes can be controlled to regulate retinal vascular diseases. Therefore, this review suggests that exosomal noncoding RNA could be considered as a biomarker for diagnosis and as a therapeutic target for treating retinal vascular disease. | Heo, Jong-Ik; Ryu, Juhee | Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea | 58881241500; 57208255566 | juheeryu@knu.ac.kr; | MOLECULAR THERAPY NUCLEIC ACIDS | MOL THER NUCL ACIDS | 2162-2531 | 35 | 1 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 6.1 | 17.2 | 2.51 | 2025-05-07 | 12 | 12 | CELL-DERIVED EXOSOMES; MESENCHYMAL STEM-CELLS; ENDOTHELIAL GROWTH-FACTOR; CIRCULAR RNA; ENGINEERING EXOSOMES; INTRAVITREAL AFLIBERCEPT; EXTRACELLULAR VESICLES; DIABETIC-RETINOPATHY; RETINITIS-PIGMENTOSA; UP-REGULATION | circular RNA; exosomal RNA; long noncoding RNA; microRNA; MT: Novel therapeutic targets and biomarker development Special Issue; noncoding RNA; retinal vascular disease | circular ribonucleic acid; long untranslated RNA; microRNA; untranslated RNA; age related macular degeneration; cancer therapy; cardiovascular disease; cell engineering; clinical assessment; clinical research; clinical trial (topic); coronavirus disease 2019; diabetic macular edema; diabetic retinopathy; dry eye syndrome; exosome; gene expression; gene function; genetic engineering; human; malignant neoplasm; nonhuman; phase 1 clinical trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); regulatory mechanism; retinal vascular disease; Review; therapy effect | English | 2024 | 2024-03-12 | 10.1016/j.omtn.2024.102128 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | High-performance and selective semi-transparent perovskite solar cells using 3D-structured FTO | Perovskite solar cells (PSCs) have been in the spotlight as a promising next-generation solar cell. With the tremendous development of power conversion efficiency (PCE) over the past decades, a considerable amount of research has focused on semi-transparent perovskite solar cells for applications. However, the short-circuit current density (JSC) greatly decreases in semi-transparent PSCs with an increase in transmittance, and this results in a significant decrease in PCE. In this study, semi-transparent PSCs were fabricated by controlling the absorption layer thickness and aperture ratio using a 3D-structured FTO manufactured via processes that can work large areas (direct printing and mist-CVD). This strategy has an advantage in that the aperture ratio (transmission/entire area) can be controlled easily by adjusting pattern specification. The effect of a 3D-structured FTO enhanced the diffuse transmittance and shortened the carrier travel distance; further, it minimized the decrease in PCE because of an increase in transmittance. Our fully semi-transparent PSCs (F–PSCs) with the ITO cathode achieved a PCE of 12.0 %–14.6 %, and an average visible transmittance (AVT) of 13.4 %–17.0 %. These results demonstrate that the parameter of semi-transparent PSCs (transmittance and PCE) can be easily tailored to the application by controlling the specification of the pattern. © 2023 Elsevier Ltd | Ju, Sucheol; Choi, Seung Ju; Sung, Hansang; Kim, Minjin; Song, Ji Won; Choi, In Woo; Kim, Hak-Beom; Jo, Yimhyun; Lee, Sangwook; Yoon, Seog-Young; Kim, Dong Suk; Lee, Heon | Department of Materials Science and Engineering, Korea University, Anam-ro 145, Sungbuk-Ku, Seoul, 136-701, South Korea; Ulsan Advanced Energy Technology R&D Center, Korea Institute of Energy Research, 25 Techno Saneop-ro 55 Beon-gil, Nam-gu, Ulsan, 44776, South Korea, School of Materials Science and Engineering, Pusan National University, Busan, 46241, South Korea; Department of Materials Science and Engineering, Korea University, Anam-ro 145, Sungbuk-Ku, Seoul, 136-701, South Korea; Ulsan Advanced Energy Technology R&D Center, Korea Institute of Energy Research, 25 Techno Saneop-ro 55 Beon-gil, Nam-gu, Ulsan, 44776, South Korea; Ulsan Advanced Energy Technology R&D Center, Korea Institute of Energy Research, 25 Techno Saneop-ro 55 Beon-gil, Nam-gu, Ulsan, 44776, South Korea; Ulsan Advanced Energy Technology R&D Center, Korea Institute of Energy Research, 25 Techno Saneop-ro 55 Beon-gil, Nam-gu, Ulsan, 44776, South Korea; Ulsan Advanced Energy Technology R&D Center, Korea Institute of Energy Research, 25 Techno Saneop-ro 55 Beon-gil, Nam-gu, Ulsan, 44776, South Korea; Ulsan Advanced Energy Technology R&D Center, Korea Institute of Energy Research, 25 Techno Saneop-ro 55 Beon-gil, Nam-gu, Ulsan, 44776, South Korea; School of Materials Science and Engineering, Kyungpook National University (KNU), Daegu, 41566, South Korea; School of Materials Science and Engineering, Pusan National University, Busan, 46241, South Korea; School of Energy and Chemical Engineering, Ulsan National Institute of Science and 20 Technology (UNIST), Ulsan, 44919, South Korea; Department of Materials Science and Engineering, Korea University, Anam-ro 145, Sungbuk-Ku, Seoul, 136-701, South Korea, ZERC, 620, New Engineering Building, 73-15, Anam-ro, Seongbuk-gu, Seoul, South Korea | 57204843847; 57222334423; 57843628300; 57200517006; 57222335221; 57189686986; 55624289700; 36903636000; 57203597324; 26026722900; 55816248100; 38061465900 | heonlee@korea.ac.kr;syy3@pusan.ac.kr;kimds@unist.ac.kr; | Renewable Energy | RENEW ENERG | 0960-1481 | 1879-0682 | 222 | SCIE | ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2024 | 9.1 | 17.2 | 1.05 | 2025-05-07 | 5 | Direct printing; Mist-chemical vapor deposition; Semi-transparent perovskite solar cell; Three-dimensional-structured fluorine doped tin oxide | Conversion efficiency; Nanocomposites; Perovskite; Perovskite solar cells; Specifications; Tin oxides; Aperture ratio; Chemical vapour deposition; Direct printing; Fluorine doped-tin oxides; Mist-chemical vapor deposition; Performance; Power conversion efficiencies; Semi-transparent; Semi-transparent perovskite solar cell; Three-dimensional-structured fluorine doped tin oxide; electrode; fuel cell; performance assessment; perovskite; solar power; transmittance; Chemical vapor deposition | English | Final | 2024 | 10.1016/j.renene.2023.119817 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Incidence of tuberculosis disease in individuals diagnosed with tuberculosis infection after screening: A population-based cohort study in South Korea | Objectives: Limited evidence exists regarding the impact of adherence to diverse tuberculosis (TB) preventive therapy (TPT) regimens on TB risk in individuals with TB infections (TBIs). This study aimed to examine the association between adherence to three TPT regimens and TB incidence. Methods: This population-based retrospective cohort study used South Korean national health insurance data to identify individuals who were newly diagnosed with TBI between 2015 and 2020. TB incidence was compared among the different TPT regimens used. Treatment adherence was evaluated using the medication possession ratio (MPR). Results: The study involved 220,483 individuals with TBI, with half undergoing TPT. Over a mean 3.17-year follow-up, 2,430 cases of active TB were observed. TPT was associated with a 14% reduction in TB incidence risk in the entire study population with varying levels of TB risk. Non-adherence (MPR = 80%) reduced the risk of TB incidence by up to 72%. Conclusions: This study reveals increased adherence with shorter TPT regimens in a national TBI cohort, emphasizing the pivotal role of medication adherence in preventing TB. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) | Lee, Jaehee; Kim, Dohyang; Hwang, Jinseub; Kwon, Jin-Won | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Daegu Univ, Dept Stat, Gyeongbuk, South Korea; Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug D, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea | ; Lee, Jaehee/S-1697-2018; Lee, Yoojin/AAB-9799-2022 | 13805476000; 57218821860; 57189231296; 16202951700 | jwkwon@knu.ac.kr; | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | INT J INFECT DIS | 1201-9712 | 1878-3511 | 141 | SCIE | INFECTIOUS DISEASES | 2024 | 4.3 | 17.2 | 0.65 | 2025-05-07 | 2 | 2 | Tuberculosis preventive therapy; Tuberculosis infection; Medication possession ratio; Tuberculosis; South Korea | ISONIAZID PREVENTIVE THERAPY; LATENT TUBERCULOSIS | Medication possession ratio; South Korea; Tuberculosis; Tuberculosis infection; Tuberculosis preventive therapy | Antitubercular Agents; Cohort Studies; Humans; Incidence; Isoniazid; Latent Tuberculosis; Republic of Korea; Retrospective Studies; Rifampin; Tuberculosis; isoniazid; rifampicin; isoniazid; rifampicin; tuberculostatic agent; adult; aged; Article; cohort analysis; controlled study; female; follow up; human; incidence; major clinical study; male; mass screening; national health insurance; patient compliance; population health; prophylaxis; retrospective study; risk assessment; risk factor; South Korea; treatment duration; tuberculosis; very elderly; complication; epidemiology; incidence; latent tuberculosis; South Korea; tuberculosis | English | 2024 | 2024-04 | 10.1016/j.ijid.2024.02.004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Investigation on the thermal control and performance of PCM-porous media-integrated heat sink systems: Deep neural network modelling employing experimental correlations | Phase change material (PCM)-based heat sinks can offer reliable and effective thermal management (TM) solutions for increasingly sophisticated applications. A critical aspect of such heat sinks is determining how long it takes them to reach a set-point temperature. However, no generalised method exists in the literature that can predict and interpret the thermal performance of a wide range of PCM-porous media-integrated heat sinks. In this regard, this study examines the heat transfer characteristics of PCM-based heat sinks integrated with various metallic foams through experimental and deep learning (DL) techniques. The experiments are performed for transient TM analysis of various PCM-based heat sinks. Diverse variables, including foam porosity (0.95-0.97), PCM fraction (0.6-0.8), heat flux (0.8-2.4 kW/m2), foam materials (Fe-Ni alloy, Ni and copper) and PCM type (RT-35HC, RT-44HC, RT-54HC and paraffin wax), are investigated in this study. The experimental data are fed to the optimal DL model using the Bayesian surrogate model-tuned hyperparameters. Utilising a correlation analysis, as exemplified by the heat map and correlation plot, in conjunction with explainable artificial intelligence, it has been deduced that the thermal performance of the heat sink is principally influenced by factors such as PCM type, PCM fraction, foam material, foam porosity, and heat flux. Comparing the model's predicted data with the empirical findings, a good agreement was observed. Specifically, the mean absolute error (MAE) for the anticipated temperature and gradient registered at 0.0438 and 0.0054, whilst the mean square error (MSE) manifested values of 0.0579 and 0.0087, respectively. The proposed model can accurately assess the heat sink's thermal performance (correlation coefficient, R2 = 0.99) for various PCM types, fractions, foam materials, applied heat flux and foam porosity. | Rehman, Tauseef-ur; Sajjad, Uzair; Lamrani, Bilal; Shahsavar, Amin; Ali, Hafiz Muhammad; Yan, Wei-Mon; Park, Cheol Woo | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Natl Taipei Univ Technol, Dept Energy & Refrigerating Air Conditioning Engn, Taipei 10608, Taiwan; Natl Taipei Univ Technol, Res Ctr Energy Conservat New Generat Residential C, Taipei 10608, Taiwan; Univ Mohammed V Rabat, Fac Sci, Lab MANAPSE, BP 1014 RP, Rabat, Morocco; Kermanshah Univ Technol, Dept Mech Engn, Kermanshah, Iran; King Fahd Univ Petr & Minerals, Mech Engn Dept, Dhahran 31261, Saudi Arabia; King Fahd Univ Petr & Minerals, Interdisciplinary Res Ctr Renewable Energy & Power, Dhahran 31261, Saudi Arabia | ; Sajjad, Uzair/AAV-8645-2021; LAMRANI, Bilal/IQS-2711-2023; Rehman, Tauseef-ur/AAE-3086-2022; Ali, HM/AAH-3473-2021 | 57159403400; 57202950663; 57203242590; 36523886500; 55749198400; 57200197835; 7408416474 | chwoopark@knu.ac.kr; | RENEWABLE ENERGY | RENEW ENERG | 0960-1481 | 1879-0682 | 220 | SCIE | ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2024 | 9.1 | 17.2 | 3.22 | 2025-04-16 | 15 | 17 | Bayesian optimisation; Deep learning; Heat sink; Phase change materials; Thermal management | PHASE-CHANGE MATERIALS; NUMERICAL-SIMULATION; ENERGY STORAGE; FOAM; COMPOSITES; MANAGEMENT; NICKEL; FLOW; ENHANCEMENT; ACID | Bayesian optimisation; Deep learning; Heat sink; Phase change materials; Thermal management | Deep neural networks; Heat flux; Heat sinks; Heat transfer; Mean square error; Nickel alloys; Phase change materials; Porosity; Bayesian optimization; Deep learning; Foam material; Integrated heat; Material fractions; Material's type; Material-based; Porous medium; Thermal control; Thermal Performance; artificial neural network; Bayesian analysis; foam; heat flux; heat transfer; machine learning; porosity; Temperature control | English | 2024 | 2024-01 | 10.1016/j.renene.2023.119719 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Optimization of wind farm power output using wake redirection control | The wake effect, which is caused by the upstream turbines in a wind farm, adversely affects the efficiency of downstream turbines, leading to reduced energy generation and increased turbine fatigue loading. To mitigate this effect, a real-time wind farm control technique, i.e., wake redirection control (WRC), employing teaching learning-based optimization (TLBO) is introduced. This technique redirects the wakes away from the downstream turbines in real time, allowing them to generate more power by sacrificing some of the power generated by the upstream turbines. As a result, the total power generated by the wind farm is maximized. A low-fidelity 20-turbine real-life offshore wind farm is modeled and simulated in FLORISSEM, the MATLAB version of the FLORIS (FLOw Redirection and Induction in Steady-state). The power produced by the wind farm model is maximized in real time by employing TLBO. The optimization results (i.e., the optimized yaw angles) are validated using the corresponding high-fidelity wind farm model developed in SOWFA (Simulator fOr Wind Farm Applications). Various results are presented to demonstrate that the TLBO-based WRC positively affects the power generated by the wind farm. | Balakrishnan, Raj Kiran; Son, Eunkuk; Hur, Sung-ho | Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Daehakro, Daegu 41566, South Korea; Korea Inst Energy Res, Jeju Global Res Ctr JGRC, Wind Energy Res Dept, 200 Haemajihaean Ro, Jeju Si 63357, Jeju Do, South Korea | 57656299100; 52264507100; 36455858700 | shur@knu.ac.kr; | RENEWABLE ENERGY | RENEW ENERG | 0960-1481 | 1879-0682 | 235 | SCIE | ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2024 | 9.1 | 17.2 | 0.63 | 2025-05-07 | 2 | 4 | Optimization; Teaching learning-based optimization; Wake effect; Wake redirection control; Wind farm control | LEARNING-BASED OPTIMIZATION; TURBINE WAKES; MODEL; SIMULATION; DESIGN; FLORIS | Optimization; Teaching learning-based optimization; Wake effect; Wake redirection control; Wind farm control | MATLAB; Offshore wind turbines; Windmill; Down-stream; Optimisations; Power; Real- time; Teaching-learning-based optimizations; Wake effect; Wake redirection control; Wind farm; Wind farm control; Wind farm models; fatigue; optimization; power generation; real time; teaching; turbine; wake; wind farm; Offshore wind farms | English | 2024 | 2024-11 | 10.1016/j.renene.2024.121357 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Prognostic significance of combined PD-L1 expression in malignant and infiltrating cells in hepatocellular carcinoma treated with atezolizumab and bevacizumab | Background: Programmed death-ligand 1 (PD-L1) expression is abundant not only in malignant cells but also in infiltrating cells within the tumor microenvironment (TME) of hepatocellular carcinoma (HCC). This study explored the association between PD-L1 expression in TME and outcomes in HCC patients treated with atezolizumab plus bevacizumab (AB), emphasizing the implications of PD-L1 expression in both malignant and tumor-infiltrating cells. Methods: This study included 72 patients with HCC who underwent percutaneous core needle liver biopsy before AB treatment between September 2020 and December 2023. PD-L1 expression on tumor tissues was assessed using the combined positive score (CPS) with cutoff values of 1 and 10, utilizing antibody clone 22C3 (Dako). Results: The distribution of PD-L1 CPS included 24 patients with CPS = 10. Significant differences in overall survival (OS) were observed across the three groups, with CPS >= 10 showing the highest survival rates (p = 0.010). Patients with CPS >= 10 had better OS than those with CPS = 1 had better OS than CPS = 10 group had the highest median PFS of 11.0 months among the three groups (P = 0.044). Objective response rates (ORR) were higher in the PD-L1 CPS >= 10 group than in the 1-10 and = 10 and >= 1 were associated with favorable outcomes regarding OS (hazard ratio [HR] 0.283, P = .027 and HR 0.303, P = .006, respectively). Conclusions: Combined analysis of PD-L1 expression in malignant and tumor-infiltrating cells can be a promising biomarker for the prognosis of HCC patients treated with AB. | Lee, Jaejun; Yoo, Jae-Sung; Kim, Ji Hoon; Lee, Dong Yeup; Yang, Keungmo; Kim, Bohyun; Choi, Joon-Il; Jang, Jeong Won; Choi, Jong Young; Yoon, Seung Kew; Han, Ji Won; Sung, Pil Soo | Catholic Univ, Liver Res Ctr, Coll Med, Dept Biomed & Hlth Sci, Seoul, South Korea; Catholic Univ, Seoul St Marys Hosp, Coll Med, Div Hepatol,Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Catholic Univ, Uijeongbu St Marys Hosp, Coll Med, Dept Internal Med,Div Hepatol, Seoul, South Korea; Catholic Univ, Seoul St Marys Hosp, Coll Med, Dept Radiol, Seoul, South Korea | Sung, Pil/K-2072-2019; Jang, Jeong/LOS-2890-2024 | 56643301500; 58567192800; 58027048600; 59231232000; 57211494507; 57791012600; 7501395833; 7402965009; 57203732617; 59293877400; 57206611002; 57206341074 | tmznjf@catholic.ac.kr;pssung49@gmail.com; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 15 | SCIE | IMMUNOLOGY | 2024 | 5.9 | 17.2 | 0 | 2025-05-07 | 1 | 1 | PD-L1; HCC; atezolizumab; overall survival; objective response | OPEN-LABEL; PHASE-II; IMMUNOHISTOCHEMISTRY; MULTICENTER | atezolizumab; HCC; objective response; overall survival; PD-L1 | Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Bevacizumab; Biomarkers, Tumor; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Lymphocytes, Tumor-Infiltrating; Male; Middle Aged; Prognosis; Treatment Outcome; Tumor Microenvironment; atezolizumab; bevacizumab; programmed death 1 receptor; antineoplastic agent; atezolizumab; bevacizumab; CD274 protein, human; monoclonal antibody; programmed death 1 ligand 1; tumor marker; adult; area under the curve; Article; cancer cell; cancer staging; CD8+ T lymphocyte; Child Pugh score; combined positive score; complete response; computer assisted tomography; Cox regression analysis; disease control rate; dynamic magnetic resonance imaging; estimated glomerular filtration rate; female; follow up; health care policy; human; human tissue; immunohistochemistry; infiltrating cell; interrater reliability; Kaplan Meier method; liver biopsy; liver cell carcinoma; lymphocyte count; major clinical study; male; middle aged; multicenter study; multivariate analysis; nuclear magnetic resonance imaging; objective response rate; outcome assessment; overall survival; partial response; progression free survival; prothrombin time; receiver operating characteristic; sensitivity analysis; sensitivity and specificity; subgroup analysis; survival rate; treatment response; tumor microenvironment; tumor volume; aged; diagnosis; drug therapy; immunology; liver cell carcinoma; liver tumor; metabolism; mortality; pathology; prognosis; treatment outcome; tumor associated leukocyte | English | 2024 | 2024-12-10 | 10.3389/fimmu.2024.1506355 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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