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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Editorial Material | Acute Hemorrhagic Encephalomyelitis in the Context of MOG Antibody-Associated Disease. Comment on Chen et al. Rapid Progressive Fatal Acute Hemorrhagic Encephalomyelitis. Diagnostics 2023, 13, 2481 | The study by Chen et al. of a 56-year-old man diagnosed with acute hemorrhagic encephalomyelitis (AHEM) had a significant impact on us. The authors provided a comprehensive account of their diagnostic journey and emphasized the need to differentiate myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) from AHEM. However, recent research suggests that AHEM may not be an isolated entity, but rather a phenotype within MOGAD. The patient's clinical presentation included MRI brain lesions characteristic of MOGAD in addition to hemorrhagic abnormalities. These findings raise the possibility that AHEM in this case represents a MOGAD phenotype. In conclusion, it is important to recognize the potential association between AHEM and MOGAD, especially when distinct MOGAD brain MRI patterns are present, as in this case. | Kim, Sohyeon; Eun, Mi-Yeon; Lee, Jae-Joon; Seok, Hung Youl | Keimyung Univ, Sch Med, Dongsan Hosp, Dept Neurol, Daegu 42601, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu 41404, South Korea | Eun, Mi-Yeon/AAV-2877-2021; Seok, Hung Youl/HZI-4365-2023 | 57214724357; 36463396500; 57209362997; 24472118000 | bjksh@naver.com;eunmiyn@gmail.com;hypersonan@gmail.com;shy2354@gmail.com; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 13 | 19 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 1.6 | 2025-06-25 | 3 | 3 | acute hemorrhagic encephalomyelitis; myelin oligodendrocyte glycoprotein | acute hemorrhagic encephalomyelitis; myelin oligodendrocyte glycoprotein | aquaporin 4; autoantibody; corticosteroid; cyclophosphamide; immunoglobulin; methylprednisolone; myelin oligodendrocyte glycoprotein; myelin oligodendrocyte glycoprotein antibody; unclassified drug; acute hemorrhagic leukoencephalitis; adult; antibody titer; aphasia; blurred vision; brain damage; brain hemorrhage; brain injury; brain stem injury; case report; cerebellum injury; clinical article; convalescence; disease association; disease exacerbation; facial nerve paralysis; fatality; gray matter; hemiparesis; human; immunotherapy; Letter; male; mental disease; middle aged; myelin oligodendrocyte glycoprotein antibody associated disease; myelitis; neuroimaging; neurological complication; nuclear magnetic resonance imaging; optic neuritis; outcome assessment; phenotype; plasma exchange; steroid therapy; T2 weighted imaging; white matter | English | 2023 | 2023-10 | 10.3390/diagnostics13193148 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Acute Ileal Diverticulitis: Computed Tomography and Ultrasound Findings | Background: Acute ileal diverticulitis is a rare disease mimicking acute appendicitis. Inaccurate diagnosis with a low prevalence and nonspecific symptoms leads to delayed or improper management. Methods: This retrospective study aimed to investigate the characteristic sonographic (US) and computed tomography (CT) findings with clinical features in seventeen patients with acute ileal diverticulitis diagnosed between March 2002 and August 2017. Results: The most common symptom was abdominal pain (82.3%, 14/17) localized to the right lower quadrant (RLQ) in 14 patients. The characteristic CT findings of acute ileal diverticulitis were ileal wall thickening (100%, 17/17), identification of inflamed diverticulum at the mesenteric side (94.1%, 16/17), and surrounding mesenteric fat infiltration (100%, 17/17). The typical US findings were outpouching diverticular sac connecting to the ileum (100%, 17/17), peridiverticular inflamed fat (100%, 17/17), ileal wall thickening with preserved layering pattern (94.1%, 16/17), and increased color flow to the diverticulum and surrounding inflamed fat on color Doppler imaging (100%, 17/17). The perforation group had a significantly longer hospital stay than non-perforation group (p = 0.002). In conclusion, acute ileal diverticulitis has characteristic CT and US findings that allow radiologists to accurately diagnose the disease. | Kwon, Lyo Min; Lee, Kwanseop; Kim, Min-Jeong; Lee, In Jae; Kim, Gab Chul | Hallym Univ, Coll Med, Dept Radiol, Sacred Heart Hosp, Anyang 14068, South Korea; Kyungpook Natl Univ, Dept Radiol, Med Ctr, Daegu 41404, South Korea | Kwon, Lyo/ABC-5338-2020 | 56915815100; 55986760800; 57026490400; 55455770100; 23004499400 | drkmj@hallym.or.kr; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 13 | 8 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.38 | 2025-06-25 | 1 | 2 | diverticulitis; ileum; tomography; X-ray computed; ultrasonography; perforation | SMALL-BOWEL DIVERTICULITIS; JEJUNOILEAL DIVERTICULITIS; CT; PERFORATION; MANAGEMENT; DIAGNOSIS | diverticulitis; ileum; perforation; tomography; ultrasonography; X-ray computed | antibiotic agent; abdominal pain; abdominal tenderness; acute diverticulitis; acute ileal diverticulitis; acute ileal diverticulitis; adult; aged; appendectomy; appendicitis; Article; chill; cholecystitis; clinical article; clinical feature; clinical outcome; color Doppler flowmetry; comparative study; conservative treatment; controlled study; diarrhea; epigastric pain; female; fever; follow up; hospitalization; human; intestine perforation; leukocytosis; male; middle aged; multidetector computed tomography; nausea; patient history of surgery; peritonitis; retrospective study; symptom; vomiting; x-ray computed tomography | English | 2023 | 2023-04 | 10.3390/diagnostics13081408 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Application of an Intraoperative Limb Positioner for Adjustable Traction in Both-Column Fractures of the Acetabulum: A Technical Note with Clinical Outcome | Traction of the ipsilateral leg is usually required to facilitate fracture reduction while operating both-column acetabular fractures. However, it is challenging to maintain constant traction manually during the operation. Herein, we surgically treated such injuries while maintaining traction using an intraoperative limb positioner and investigated the outcomes. This study included 19 patients with both-column acetabular fractures. Surgery was performed after the patient's condition had stabilized, at an average of 10.4 days after injury. The Steinmann pin was transfixed to the distal femur and connected to a traction stirrup; subsequently, the construct was affixed to the limb positioner. A manual traction force was applied through the stirrup and maintained with the limb positioner. Using a modified Stoppa approach combined with the lateral window of the ilioinguinal approach, the fracture was reduced, and plates were applied. Primary union was achieved in all cases at an average of 17.3 weeks. The quality of reduction at the final follow-up was found to be excellent, good, and poor in 10, 8, and 1 patients, respectively. The average Merle d'Aubigne score at the final follow-up was 16.6. Surgical treatment of both-column acetabular fracture using intraoperative traction with a limb positioner yields satisfactory radiological and clinical outcomes. | Kim, Joon-Woo; Oh, Chang-Wug; Park, Kyeong-Hyeon; Hong, Won-Ki; Yoon, Sung-Hyuk; Lee, Gwang-Sub; Oh, Jong-Keon | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthoped Surg, Daegu 41944, South Korea; Korea Univ Guro Hosp, Sch Med, Dept Orthoped Surg, Seoul 10408, South Korea | ; Hong, Wonki/AAC-6283-2021; Oh, Chang-Wug/AAO-4602-2021; Park, KyeongHyeon/KEH-4919-2024 | 22951329000; 22135834200; 56969984400; 57218322356; 56323207000; 58118421700; 7402155046 | cwoh@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 4 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.26 | 2025-06-25 | 2 | 1 | acetabular fracture; both-column fracture; intraoperative traction; limb positioner | MANAGEMENT; REDUCTION; HIP | acetabular fracture; both-column fracture; intraoperative traction; limb positioner | acetabulum fracture; adult; aged; Article; clinical article; clinical outcome; distal femur; female; femur head necrosis; follow up; fracture healing; fracture reduction; hip arthroplasty; human; intraoperative period; male; middle aged; osteoarthritis; postoperative period; surgical approach; surgical technique; traction therapy; very elderly; weight bearing; young adult | English | 2023 | 2023-02 | 10.3390/jcm12041682 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Association between Anterior Surgical Approach and Dysphagia Severity in Patients with Cervical Spinal Cord Injury | Introduction: Early detection and management of dysphagia are essential for preventing aspiration pneumonia and reducing mortality in patients with cervical spinal cord injury (C-SCI). In this study, we identified risk factors for dysphagia in patients with C-SCI by analyzing the correlation between the clinical factors and the severity of dysphagia, not the presence or absence of dysphagia. Combined with the analysis results of previous studies, we thought that this additional analysis method could more accurately reveal the risk factors for dysphagia in patients with C-SCI. Methods: The presence and severity of dysphagia in patients with C-SCI was evaluated using a modified videofluoroscopic dysphagia scale (mVDS) and penetration-aspiration scale (PAS). All included patients with C-SCI performed a video fluoroscopic swallowing study (VFSS). Clinical factors such as age, sex, the presence of tracheostomy, spinal cord independence measure (SCIM), pulmonary function test (PFT), including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FVC/FEV1, maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP), American Spinal Cord Injury Association (ASIA) score, Berg Balance Scale (BBS), and operation method were investigated. Results: In the multivariate regression analysis, the anterior surgical approach was the only clinical factor that had a significant correlation in both mVDS and PAS, which represents the severity of dysphagia in C-SCI patients (p < 0.05). Conclusion: The anterior surgical approach was correlated with the severity of dysphagia in patients with C-SCI. Considering this, as one of the risk factors affecting dysphagia in patients with C-SCI, surgical method may also need to be considered. Additionally, we recommend that clinicians should pay particular attention to the potential for development of dysphagia in patients who received anterior cervical surgery. However, further prospective studies with larger sample sizes are needed for more accurate generalization. | Chang, Min Cheol; Kim, Dae Yeong; Choi, Jin-Woo; Choi, Ho Yong; Park, Jin-Sung; Park, Donghwi | Yeungnam Univ Hosp, Dept Rehabil Med, Daegu 42415, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Phys Med & Rehabil, Coll Med, Ulsan 44033, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Coll Med, Dept Neurosurg, Seoul 05278, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu 41944, South Korea; Daegu Fatima Hosp, Dept Rehabil Med, Ayangro 99, Daegu 41199, South Korea | ; Chang, Min Cheol/AAE-2321-2022 | 57991534800; 58247221000; 58126912600; 57190256537; 44061744500; 56606561400 | 736043@uuh.ulsan.kr;bdome@hanmail.net; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 1.28 | 2025-06-25 | 5 | 5 | deglutition; spinal cord injury; dysphagia; tracheostomy | PENETRATION-ASPIRATION; SPONDYLOTIC MYELOPATHY; RISK-FACTORS; SURGERY; DISKECTOMY; FUSION; MANAGEMENT | deglutition; dysphagia; spinal cord injury; tracheostomy | adult; age; aged; American Spinal Injury Association impairment scale; anterior cervical surgery; Article; Berg Balance Scale; cervical spinal cord injury; clinical assessment tool; clinical feature; controlled study; correlation analysis; disease severity; dysphagia; evaluation study; female; fluoroscopy; forced expiratory volume; forced vital capacity; human; lung function test; major clinical study; male; maximal expiratory pressure; maximal inspiratory pressure; modified Videofluoroscopic Dysphagia Scale; Penetration Aspiration Scale; rating scale; risk factor; scoring system; sex; Spinal Cord Independence Measure Score; spine surgery; statistical significance; surgical approach; surgical technique; swallowing; tracheostomy; videorecording | English | 2023 | 2023-04-30 | 10.3390/jcm12093227 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Editorial Material | Benign Intranodal Thyroid Tissue Similar to Nodal Metastasis of Thyroid Papillary Carcinoma: A Rare Case Report | In patients with thyroid nodules, if the cervical lymph nodes gradually enlarge, a histological confirmation is required to rule out malignancy. Here is a case of benign intranodal thyroid tissue with cystic changes resembling lymph node metastasis of a papillary thyroid carcinoma. A 47-year-old man received ethanol sclerotherapy because of repeated enlargement of the thyroid gland 2 years prior to presentation. Subsequently, the patient underwent abscess removal from the deep neck and partial lobectomy of the attached left thyroid gland. Two months before the visit, extensive cervical lymphadenopathy was detected on ultrasonography (US) and computed tomography (CT). Total thyroidectomy and cervical lymph node dissection were performed to differentiate between metastatic papillary carcinoma of the thyroid gland and benign thyroid inclusions. Microscopic examination revealed multiple variable-sized nodules of benign thyroid follicles with cystic changes in both thyroid glands and bilateral cervical lymph nodes. An occult papillary microcarcinoma strongly positive for HBME-1 was also observed in the left thyroid lobe. However, the benign intranodal thyroid tissue was negative in both the real-time PCR-based BRAF V600E mutation test and HBME-1 immunohistochemical stain. Similarly, benign intranodal thyroid tissue can be enlarged by multiple cystic changes in a large number of lymph nodes along the neck node chain. For the differentiation of metastatic thyroid papillary carcinoma, real-time PCR-based BRAF V600E mutation test and HBME-1 immunohistochemical staining in addition to histological examination are helpful. | Kang, Yoo-Na; Cha, Jung-Guen | Kyungpook Natl Univ, Sch Med, Dept Forens Med, 680 Guk Chaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 7402784356; 57206855971 | yoonakang@knu.ac.kr; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 13 | 3 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0 | 2025-06-25 | 0 | 0 | intranodal; thyroid gland; papillary carcinoma | CERVICAL LYMPH-NODES; INCLUSIONS; PATIENT; GLAND | intranodal; papillary carcinoma; thyroid gland | alcohol; B Raf kinase; hbme 1 protein; tumor marker; unclassified drug; abscess; adult; Article; cancer diagnosis; cancer surgery; case report; cervical lymph node; cervical lymphadenopathy; clinical article; computer assisted tomography; echography; fine needle aspiration biopsy; gene mutation; human; human tissue; immunohistochemistry; lobectomy; lymph node dissection; lymph node metastasis; lymphadenopathy; male; microscopy; middle aged; nodular hyperplasia; real time polymerase chain reaction; sclerotherapy; thymectomy; thyroid disease; thyroid nodule; thyroid papillary carcinoma; total thyroidectomy | English | 2023 | 2023-02 | 10.3390/diagnostics13030577 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Biomarkers for Predicting Response to Personalized Immunotherapy in Gastric Cancer | Despite advances in diagnostic imaging, surgical techniques, and systemic therapy, gastric cancer (GC) is the third leading cause of cancer-related death worldwide. Unfortunately, molecular heterogeneity and, consequently, acquired resistance in GC are the major causes of failure in the development of biomarker-guided targeted therapies. However, by showing promising survival benefits in some studies, the recent emergence of immunotherapy in GC has had a significant impact on treatment-selectable procedures. Immune checkpoint inhibitors (ICIs), widely indicated in the treatment of several malignancies, target inhibitory receptors on T lymphocytes, including the programmed cell death protein (PD-1)/programmed death-ligand 1 (PD-L1) axis and cytotoxic T-lymphocyte-associated protein 4 (CTLA4), and release effector T-cells from negative feedback signals. In this article, we review currently available predictive biomarkers (including PD-L1, microsatellite instability, Epstein-Barr virus, and tumor mutational burden) that affect the ICI treatment response, focusing on PD-L1 expression. We further briefly describe other potential biomarkers or mechanisms for predicting the response to ICIs in GC. This review may facilitate the expansion of the understanding of biomarkers for predicting the response to ICIs and help select the appropriate therapeutic approaches for patients with GC. | Kim, Moonsik; Jeong, Ji Yun; Seo, An Na | Kyungpook Natl Univ, Sch Med, Dept Pathol, 136 Gil 90, Daegu 41405, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Pathol, 807 Hogukno, Daegu 41404, South Korea | ; Seo, An Na/F-6440-2015 | 57195918515; 57205472984; 55804153700 | teiroa83@knuh.kr;jjiyun@gmail.com;san_0729@naver.com; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 13 | 17 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.4 | 2025-06-25 | 7 | 6 | gastric cancer; immunotherapy; molecular pathology; biomarker; programmed cell death-ligand 1 | EXPRESSION-BASED CLASSIFICATION; TUMOR MUTATIONAL BURDEN; PLUS CHEMOTHERAPY; PD-L1; HETEROGENEITY; SUBTYPES; PROTEIN; SAMPLES | biomarker; gastric cancer; immunotherapy; molecular pathology; programmed cell death-ligand 1 | cytotoxic T lymphocyte antigen 4; epidermal growth factor receptor 2; fluoropyrimidine; immune checkpoint inhibitor; nivolumab; pembrolizumab; programmed death 1 ligand 1; programmed death 1 receptor; trastuzumab; adenocarcinoma; adult; cancer patient; Epstein Barr virus; esophageal adenocarcinoma; gastroesophageal junction; gene expression; human; human cell; immunotherapy; microsatellite instability; molecular pathology; negative feedback; nonhuman; protein expression; regulated cell death; reproducibility; Review; scoring system; stomach cancer; T lymphocyte; treatment response; tumor mutational burden | English | 2023 | 2023-09 | 10.3390/diagnostics13172782 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Change in Severity and Clinical Manifestation of MIS-C Over SARS-CoV-2 Variant Outbreaks in Korea | Background: There is difference in the incidence of multi-system inflammatory syndrome in children (MIS-C) in patients with different variants of severe acute respiratory syndrome coronavirus 2, however, little is known about the epidemiology in Asian countries. We investigated and compared the epidemiology of the MIS-C during omicron-dominant period with that of previous periods in South Korea. Methods: We obtained clinical, epidemiological and laboratory data on MIS-C cases from national MIS-C surveillance in South Korea. We defined pre-delta period as January 2020-May 2021; delta period as June 2021-December 2021; and omicron period as January 2022-April 2022. We describe the clinical characteristics and outcomes of MIS-C patients by period. Results: A total of 91 cases were assessed to be MIS-C cases. Number of MIS-C cases have increased from six cases during pre-delta period to 66 cases during omicron period, while the incidence rate (the number of MIS-C cases per 100,000 cases of reported coronavirus disease 2019) has decreased from 38.5 cases per 100,000 (95% confidence interval [CI], 14.1-83.9) during pre-delta period to 1.6 cases per 100,000 (95% CI, 1.2-2.0) during omicron periods. During pre-delta period, 66.7% and 100% had hypotension and gastrointestinal involvement, respectively; while during omicron period, 12.1% and 6.1% had such clinical manifestations. Fifty percent of pre-delta MIS-C patients were taken intensive care unit (ICU) cares, while 10.6% of patients during omicron periods were in ICUs. Conclusion: Omicron period were associated with less severe clinical manifestation compared to pre-delta and delta periods. Although incidence rate of MIS-C was lower for the omicron period than pre-delta and delta periods, number of patients reported with MIS-C may pose a substantial clinical burden. | Choe, Young June; Choi, Eun Hwa; Choi, Jong Woon; Eun, Byung Wook; Eun, Lucy Youngmin; Kim, Yae-Jean; Kim, Yeo Hyang; Kim, Young A.; Kim, Yun-Kyung; Kwak, Ji Hee; Lee, Hyukmin; Park, June Dong; Jung, Yeon Haw; Gwack, Jin; Lee, Sangwon | Korea Univ, Anam Hosp, Dept Pediat, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Pediat, Seoul, South Korea; Bundang Jesaeng Gen Hosp, Dept Pediat, Seongnam, South Korea; Nowon Eulji Univ Hosp, Dept Pediat, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Pediat, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Dept Pediat, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Pusan Natl Univ, Sch Med, Dept Pediat, Yangsan, South Korea; Korea Univ, Dept Pediat, Coll Med, Seoul, South Korea; Kangbuk Samsung Hosp, Dept Pediat, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Lab Med, Seoul, South Korea; Korea Dis Control & Prevent Agcy, Gen Publ Hlth Emergency Preparedness, Cheongju, South Korea; Seoul Natl Univ, Coll Med, Dept Pediat, 101 Daehak Ro, Seoul 03080, South Korea | Kim, Young A/HSG-2689-2023; KIM, YUN/E-8331-2011; Park, June/J-5496-2012; Eun, Byungwook/NAZ-8644-2025; Kim, Junetae/AAS-1234-2021; Choe, Young/AAG-6632-2021 | 36859299800; 24066557000; 56126677700; 12762260900; 55914286000; 7410198066; 57032023800; 59842792500; 8709854400; 56041753900; 8872234300; 8621069800; 57223085097; 23134705500; 57208560129 | eunchoi@snu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 30 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 2.81 | 2025-06-25 | 10 | 11 | MIS-C; COVID-19; SARS-CoV-2 | MULTISYSTEM INFLAMMATORY SYNDROME; OMICRON VARIANT; SOUTH-KOREA; COVID-19; DISEASE; CHILDREN; SURVEILLANCE; VACCINE | COVID-19; MIS-C; SARS-CoV-2 | Child; COVID-19; Disease Outbreaks; Humans; pediatric multisystem inflammatory disease, COVID-19 related; Republic of Korea; SARS-CoV-2; SARS-CoV-2 variants; child; coronavirus disease 2019; epidemic; human; Severe acute respiratory syndrome coronavirus 2; South Korea | English | 2023 | 2023-07-31 | 10.3346/jkms.2023.38.e225 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Changes in the End-of-Life Process in Patients with Life-Limiting Diseases through the Intervention of the Pediatric Palliative Care Team | Kyungpook National University Children's Hospital initiated pediatric palliative care (PPC) services in January 2019, focusing on children and adolescents with life-limiting conditions (LLC). A study examined changes in the end-of-life processes in patients with LLC before and after a PPC intervention. This study included 48 deceased patients under 18 years at the hospital, divided into two groups: January 2015 to December 2016 without PPC (25 patients, Period 1) and January 2019 to April 2022 with PPC (23 patients, Period 2). Analysis of medical records revealed the following: no age/sex differences; more active advanced care planning in Period 2 (15/23 vs. 7/25, p = 0.01); discussing withholding/withdrawing treatment increased in Period 2 (91.3% vs. 64.0%, p = 0.025); intubation and CPR were less frequent in Period 2 (intubation 2/23 vs. 19/25, p = 0.000; CPR 3/23 vs. 11/25, p = 0.018); Period 1 had more deaths in the ICU (18/25 vs. 10/23, p = 0.045); and 3 patients in Period 2 chose home deaths. A survey in Period 2 revealed high satisfaction with emotional support (91.7%), practical assistance (91.6%), and symptom management (83.3%). PPC facilitated discussions on advanced care planning and treatment choices, ensuring peaceful and prepared farewells for children with LLC and their families. | Kwon, Jung Eun; Kim, Yeo Hyang | Kyungpook Natl Univ, Childrens Hosp, Pediat Palliat Care Ctr, Sch Med,Dept Pediat, Daegu 41404, South Korea | 57194002366; 57032023800 | lovecello623@gmail.com;kimyhmd@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 20 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.51 | 2025-06-25 | 1 | 2 | advanced care planning; child; intubation; palliative care | CHILDREN; IMPACT | advanced care planning; child; intubation; palliative care | adolescent; adult; advance care planning; Article; at home mortality; child; clinical article; controlled study; emotional support; endotracheal intubation; family decision making; female; follow up; groups by age; human; infant; intensive care unit; male; palliative therapy; patient decision making; resuscitation; retrospective study; terminal care | English | 2023 | 2023-10 | 10.3390/jcm12206588 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Clinical Practice Guideline for Gastritis in Korea | Gastritis is a disease characterized by inflammation of the gastric mucosa. It is very common and has various classification systems such as the updated Sydney system. As there is a lot of evidence that Helicobacter pylori infection is associated with the development of gastric cancer and that gastric cancer can be prevented by eradication, H. pylori gastritis has been emphasized recently. The incidence rate of gastric cancer in Korea is the highest in the world, and due to the spread of screening endoscopy, atrophic gastritis and intestinal metaplasia are commonly diagnosed in the general population. However, there have been no clinical guidelines developed in Korea for these lesions. Therefore, this clinical guideline has been developed by the Korean College of Helicobacter and Upper Gastrointestinal Research for important topics that are frequently encountered in clinical situations related to gastritis. Evidence-based guidelines were developed through systematic review and de novo processes, and eight recommendations were made for eight key questions. This guideline needs to be periodically revised according to the needs of clinical practice or as important evidence about this issue is published in the future. | Kang, Seung Joo; Kim, Jae Gyu; Moon, Hee Seok; Kook, Myeong-Cherl; Lee, Jong Yeul; Bang, Chang Seok; Tae, Chung Hyun; Gong, Eun Jeong; Nam, Su Youn; Kim, Hyun Jung | Seoul Natl Univ Hosp Healthcare Syst, Gangnam Ctr, Dept Internal Med, Seoul, South Korea; Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Chungnam Natl Univ, Coll Med, Dept Internal Med, Daejeon, South Korea; Natl Canc Ctr, Ctr Gastr Canc, Goyang, South Korea; Hallym Univ, Coll Med, Dept Internal Med, Chunchon, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Div Gastroenterol, Dept Internal Med, Daegu, South Korea; Korea Univ, Coll Med, Dept Prevent Med, Seoul, South Korea | KIM, Hyeon-Joong/C-4448-2011; Bang, Chang SEOK/I-9689-2019; Kook, Moochang/B-7001-2014; Moon, Hee Seok/AAC-6951-2022 | 51261274600; 57486236700; 35269308500; 7003734725; 15755866200; 57991522300; 35211966400; 56107863900; 55617028500; 56703907300 | jgkimd@cau.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 13 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 2.05 | 2025-06-25 | 8 | 8 | Gastritis; Helicobacter pylori; Atrophy; Intestinal Metaplasia | HELICOBACTER-PYLORI ERADICATION; INTESTINAL METAPLASIA; DOUBLE-BLIND; ATROPHIC GASTRITIS; CLINICOPATHOLOGICAL CHARACTERISTICS; EROSIVE GASTRITIS; RANDOMIZED-TRIAL; RISK-FACTORS; CANCER; SUCRALFATE | Atrophy; Gastritis; Helicobacter pylori; Intestinal Metaplasia | Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Metaplasia; Republic of Korea; Stomach Neoplasms; complication; gastritis; Helicobacter infection; Helicobacter pylori; human; metaplasia; pathology; South Korea; stomach mucosa; stomach tumor | English | 2023 | 2023-04-03 | 10.3346/jkms.2023.38.e115 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Comparing the Efficacy of Carvedilol and Flecainide on the Treatment of Idiopathic Premature Ventricular Complexes from Ventricular Outflow Tract: A Multicenter, Randomized, Open-Label Pilot Study | The mechanism of premature ventricular complexes (PVC) occurring in the ventricular outflow tract (OT) is related to an intracellular calcium overload and delayed afterdepolarizations that lead to triggered activity. The guidelines recommend using beta-blockers and flecainide for idiopathic PVCs, but they also acknowledge the limited evidence supporting this recommendation. We conducted a multicenter, randomized, open-label pilot study comparing the effect of carvedilol and flecainide on OT PVC, which are widely used to treat this arrhythmia. Patients with a 24 h Holter recording a PVC burden >= 5%, which showed positive R waves in leads II, III, and aVF, and without structural heart disease were enrolled. They were randomly assigned to the carvedilol or flecainide group, and the maximum tolerated dose was administered for 12 weeks. A total of 103 participants completed the protocol: 51 with carvedilol and 52 with flecainide. After 12 weeks of treatment, the mean PVC burden significantly decreased in both groups: 20.3 +/- 11.5 to 14.6 +/- 10.8% with carvedilol (p < 0.0001) and 17.1 +/- 9.9 to 6.6 +/- 9.9% with flecainide (p < 0.0001). Both carvedilol and flecainide effectively suppressed OT PVCs in patients without structural heart disease, with flecainide showing a superior efficacy compared to carvedilol. | Hwang, Jongmin; Oh, Yong-Seog; Park, Hyoung-Seob; Choi, Jong-Il; Lee, Young Soo; Choi, Eue-Keun; Shin, Dong-Gu; On, Young Keun; Kim, Tae-Hoon; Park, Hyung Wook; Cho, Min Soo; Bae, Myung Hwan; Han, Seongwook | Keimyung Univ, Cardiovasc Ctr, Dongsan Hosp, Daegu 42601, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Div Cardiol, Seoul 06591, South Korea; Korea Univ, Arrhythmia Ctr, Med Ctr, Anam Hosp, Seoul 02841, South Korea; Catholic Univ Daegu, Dept Cardiol, Daegu 42472, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul 03080, South Korea; Yeungnam Univ, Med Ctr, Dept Internal Med, Div Cardiol,Coll Med, Daegu 42415, South Korea; Sungkyunkwan Univ, Heart Vasc Stroke Inst, Samsung Med Ctr, Dept Internal Med,Sch Med,Div Cardiol, Seoul 06351, South Korea; Yonsei Univ, Severance Cardiovasc Hosp, Dept Internal Med, Div Cardiol,Coll Med, Seoul 03722, South Korea; Chonnam Natl Univ Hosp, Dept Cardiol, Gwangju 61469, South Korea; Univ Ulsan, Asan Med Ctr, Dept Cardiol, Coll Med, Seoul 05505, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Cardiol, Daegu 41944, South Korea | Kim, Ji/AAO-7560-2021; Choi, Eue-Keun/J-5968-2014; Kim, Jong/AAE-8556-2019; kim, Tae-hoon/GXF-5826-2022; Choi, Jong-Il/P-7476-2018 | 57215648513; 14021940000; 36175197800; 55722509800; 56368143800; 35558194200; 14045949300; 6508172107; 57188703626; 35275710300; 54796425300; 36607356800; 7405944969 | dsmcep@gmail.com;swhanepdoc@gmail.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 8 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 1.28 | 2025-06-25 | 3 | 5 | ventricular premature complexes; carvedilol; anti-arrhythmia agents | INDUCED CA2+ RELEASE; ANTIARRHYTHMIC-DRUGS; CATHETER ABLATION; HEART-FAILURE; BETA-BLOCKER; TACHYCARDIA; OUTCOMES | anti-arrhythmia agents; carvedilol; carvedilol; ventricular premature complexes | angiotensin receptor antagonist; calcium; calcium channel blocking agent; carvedilol; dipeptidyl carboxypeptidase inhibitor; diuretic agent; flecainide; hydroxymethylglutaryl coenzyme A reductase inhibitor; adult; aged; antiarrhythmic activity; Article; blurred vision; burning sensation; calcium cell level; comparative effectiveness; controlled study; disease burden; diseases; dizziness; drug dose titration; drug safety; exertional dyspnea; fatigue; female; headache; heart depolarization; heart palpitation; heart rate; heart ventricle extrasystole; Holter monitoring; human; idiopathic disease; major clinical study; male; maximum tolerated dose; multicenter study; open study; patient compliance; patient-reported outcome; pilot study; PR interval; QRS interval; R wave; randomized controlled trial; sexual dysfunction; somnolence; treatment duration; visual analog scale | English | 2023 | 2023-04 | 10.3390/jcm12082887 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparison of Clinical Outcomes of Tracheostomy between COVID-19 and Non-COVID-19 Patients | Background and Objectives: We compared decannulation-related factors between COVID-19 and non-COVID-19 patients who underwent tracheostomy. Subjects and Methods: We conducted a retrospective study of patients who underwent a tracheostomy. The clinical factors were compared between the successful (decannulation within 3 months) and failed decannulation (decannulation over 3 months) groups in COVID-19 and non-COVID-19 patients. Results: The successful decannulation rates were 41.1% in COVID-19 and 45.1% in non-COVID-19 patients, with no significant differences in demographic and clinical factors between the two groups. In the non-COVID-19 patients, the failed decannulation group had a higher proportion of cerebrovascular and pulmonary diseases. Ventilator dependency or increased oxygen demand was the primary cause of decannulation failure in both groups, with no significant differences except for a higher prevalence of swallowing problems in the COVID-19 group (42.4% vs. 20.0%). Conclusions: The predominant cause of decannulation failure was ventilator and oxygen demand in both the non-COVID-19 and COVID-19 patients. In the non-COVID-19 patients, underlying cerebrovascular diseases were considered to have a significant impact on the decannulation process. On the other hand, swallowing problems significantly influenced decannulation among the COVID-19 patients. Therefore, we should consider early and active respiratory and swallowing rehabilitation to facilitate successful decannulation in COVID-19 patients. | Jung, Sung Ha; Park, Joo Hyun; Yi, Heejun; Kim, Heejung; Lee, Gil Joon; Choi, Nayeon | Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seoul 06351, South Korea; Jeju Natl Univ, Jeju Natl Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, Jeju 63243, South Korea; Hanyang Univ, Myongji Hosp, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, Ilsan 10475, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Daegu 41944, South Korea | 57985416600; 57943966900; 58599836000; 57210863444; 57193082568; 55601531900 | jungsungha@gmail.com;youryhj@gmail.com;onlyta28@naver.com;giljoon.lee@gmail.com;chlskduschoi@naver.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 23 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0 | 2025-06-25 | 0 | 0 | tracheostomy; COVID-19; decannulation; tracheostoma | NEW-YORK-CITY; ENDOTRACHEAL INTUBATION; DYSPHAGIA; CARE | COVID-19; decannulation; tracheostoma; tracheostomy | aged; Article; cardiovascular disease; cerebrovascular accident; cerebrovascular disease; clinical outcome; controlled study; coronavirus disease 2019; decannulation; female; head and neck surgery; human; lung disease; major clinical study; male; nasopharyngeal swab; otorhinolaryngology; oxygen consumption; polymerase chain reaction; prevalence; rehabilitation care; retrospective study; swallowing; tracheostomy | English | 2023 | 2023-12 | 10.3390/jcm12237461 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Comparison Study between ERCP and PTBD for Recurrent Choledocholithiasis in Patients Following Gastrectomy | The recurrence rate of choledocholithiasis in the general population has been reported to exceed 10%. The incidence of cholelithiasis was reported to be higher in patients following gastrectomy than that in the general population. However, there is no study for recurrent choledocholithiasis incidence in patients following gastrectomy. This study aimed to evaluate the recurrence rate of choledocholithiasis and identify risk factors for recurrent choledocholithiasis in patients following gastrectomy. A retrospective analysis was performed on patients with gastrectomy history who underwent choledocholithiasis removal in Kyungpook National University Hospital between January 2011 and December 2019. Choledocholithiases were treated by endoscopic retrograde cholangiopancreatography (ERCP) (n = 41) or percutaneous transhepatic biliary drainage (PTBD) (n = 90). The gastrectomy type was classified as subtotal gastrectomy with Billroth I (18.3%), Billroth II (45.0%), and total gastrectomy with Roux-en-Y (36.6%). During a median follow-up period of 31.5 (range, 6-105) months, choledocholithiasis recurrence was noted in 19 of 131 patients (14.5%). In subgroup analysis, the ERCP group (24.4%) had higher choledocholithiasis recurrence than the PTBD group (10.0%). Stone removal modality (ERCP), no use of balloon sphincteroplasty, and the presence of periampullary diverticulum were significant risk factors for recurrent choledocholithiasis. In multivariate analysis, ERCP (hazard ratio (HR), 3.597; 95% confidence interval (CI): 1.264-10.204) CBD stricture (HR, 3.823; 95% CI: 1.118-13.080) and no use of balloon sphincteroplasty (HR, 4.830; 95% CI: 1.669-13.889) were risk factors for recurrent choledocholithiasis following stone removal. The incidence of CBD stones in patients who underwent gastrectomy is similar to that of the general population. ERCP, CBD stricture, and no use of balloon sphincteroplasty are potential risk factors for recurrent CBD stones following gastrectomy. When we consider PTBD disadvantages, the ERCP procedure with active use of balloon sphincteroplasty is recommended to decrease recurrent CBD stones. | Kweon, O. Seong; Heo, Jun; Jung, Min Kyu | Kyungpook Natl Univ, Sch Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu 41944, South Korea | Kim, Young/J-5414-2012 | 58553046300; 36448170600; 56783168100 | hero797@hanmail.net; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 13 | 16 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.19 | 2025-06-25 | 1 | 1 | gastrectomy; choledocholithiasis; endoscopic retrograde cholangiopancreatography; percutaneous transhepatic biliary drainage; recurrence | BILE-DUCT STONES; RISK-FACTORS; PREVALENCE; GALLSTONES | choledocholithiasis; endoscopic retrograde cholangiopancreatography; gastrectomy; percutaneous transhepatic biliary drainage; recurrence | aged; Article; biliary tract drainage; Charlson Comorbidity Index; cholangiography; common bile duct stone; computer assisted tomography; controlled study; diverticulosis; echography; endoscopic retrograde cholangiopancreatography; endoscopist; female; follow up; gastrectomy; gastrectomy Billroth I; gastrectomy Billroth II; human; incidence; interventional radiologist; major clinical study; male; multivariate analysis; outcome assessment; partial gastrectomy; patient history of surgery; percutaneous transhepatic biliary drainage; periampullary diverticulum; recurrence risk; recurrent disease; retrospective study; risk assessment; risk factor; Roux-en-Y gastric bypass; sphincteroplasty; total gastrectomy; Vater papilla stenosis | English | 2023 | 2023-08 | 10.3390/diagnostics13162651 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Complication Analysis in Korean Patients With Hemophilia A From 2007 to 2019: A Nationwide Study by the Health Insurance Review and Assessment Service Database | Background: There has been remarkable progress in hemophilia A (HA) treatment in Korea. Viral inactivation products were developed in 1989, use of recombinant factor VIII (FVIII) concentrates started in 2002, and prophylaxis expanded thereafter. This study was conducted to identify the changes in complications in HA before and after 1989 or 2002. Methods: The study was performed using the 2007-2019 Healthcare Big Data Hub of the Health Insurance Review and Assessment Service. Results: Among 2,557 patients, 1,084 had & GE; 1 complication; 829 had joint problems, 328 had viral infections, 146 had neurologic sequelae, and 87 underwent 113 surgeries or procedures due to complications. Patients born after 1989 had a significantly lower risk of viral infections than those born before 1989; 27.1% vs. 1.4% (P 10 years to expand prophylaxis widely. Neurologic sequelae have not decreased; thus, additional efforts to decrease intracranial hemorrhage are needed. We suggest personalized dosing of FVIII and more meticulous care during childbirth to further reduce the complications. | Choi, Young Bae; Shim, Ye Jee; Kim, Soon Gu; Lee, Won Kee | Ajou Univ, Ajou Univ Hosp, Sch Med, Dept Pediat, Suwon, South Korea; Keimyung Univ, Dongsan Hosp, Sch Med, Dept Pediat, Daegu, South Korea; Keimyung Univ, Educ Support Ctr, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Med Res Collaborat Ctr, Sch Med,Dept Med Informat, Daegu, South Korea | 57204085410; 57222517942; 57440802200; 22953484700 | yejeeshim@dsmc.or.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 30 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.51 | 2025-06-25 | 2 | 2 | Epidemiology; Hemarthrosis; Hemophilia A; Intracranial Hemorrhage; Viral Diseases | INTRACRANIAL HEMORRHAGE; EMICIZUMAB PROPHYLAXIS; JOINT DISEASE; OUTCOMES; PATHOPHYSIOLOGY; LIFE | Epidemiology; Hemarthrosis; Hemophilia A; Intracranial Hemorrhage; Viral Diseases | Hemophilia A; Humans; Insurance, Health; Intracranial Hemorrhages; Republic of Korea; brain hemorrhage; complication; health insurance; hemophilia A; human; South Korea | English | 2023 | 2023-07-31 | 10.3346/jkms.2023.38.e235 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Consensus Definition of Blood Samples from the Subcategorized Normal Controls in the Korea Biobank Network | A control group is defined as a group of people used for comparison. Depending on the type of study, it can be a group of healthy people or a group not exposed to risk factors. It is important to allow researchers to select the appropriate control participants. The Korea Biobank Project-sponsored biobanks are affiliated with the Korea Biobank Network (KBN), for which the National Biobank of Korea plays a central coordinating role among KBN biobanks. KBN organized several working groups to address new challenges and needs in biobanking. The "Normal Healthy Control Working Group" developed standardized criteria for three defined control groups, namely, normal, normal-plus, and disease-specific controls. Based on the consensus on the definition of a normal control, we applied the criteria for normal control participants to retrospective data. The main reason for exclusion from the "Normal-plus" group was blood test results beyond 5% of the reference range, including hypercholesterolemia. Subclassification of samples of normal controls by detailed criteria will help researchers select optimal normal controls for their studies. | Han, Ji Eun; Park, Min Kyu; Jin, Ju Hyun; Lee, Jung Ah; Park, Gyeongsin; Park, Jong Sook; Bae, Han-Ik; Yun, Seok Joong; Seo, An Na; Han, Man-Hoon; Lee, Hyoungnam; Jeon, Jae-Pil; Yu, Ji-In; Kim, Soon Sun; Cheong, Jae Youn | Ajou Univ Hosp, Dept Gastroenterol, Suwon 16499, South Korea; Chungbuk Natl Univ, Coll Med, Dept Clin Pharmacol & Therapeut, Cheongju 28644, South Korea; Ajou Univ Hosp, Human Genome Res & Bioresource Ctr, Suwon 16499, South Korea; Catholic Univ Korea, Biobank Seoul St Marys Hosp, Seoul 03382, South Korea; Catholic Univ Korea, Dept Hosp Pathol, Coll Med, Seoul 06591, South Korea; Soonchunhyang Univ, Dept Allergy & Pulmonol, Bucheon Hosp, Bucheon 14584, South Korea; Kyungpook Natl Univ Hosp, Dept Pathol, Daegu 41404, South Korea; Chungbuk Natl Univ, Coll Med, Dept Urol, Cheongju 28644, South Korea; Chungbuk Natl Univ Hosp, Dept Urol, Cheongju 28644, South Korea; Korea Natl Inst Hlth, Dept Precis Med, Div Biobank, Cheongju 28159, South Korea | Kim, Siwon/KHX-9078-2024; Kim, Sun/L-4239-2013 | 57454445900; 55730438600; 58247689500; 58247902300; 8406567900; 58246859100; 7103224222; 16302421300; 55804153700; 57194067936; 58246859300; 14023048100; 57188646211; 59667437100; 7004933299 | jaeyoun620@gmail.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0 | 2025-06-25 | 0 | 0 | control definition; healthy control; normal control; biospecimen; biobank; Korea Biobank Network | biobank; biospecimen; control definition; healthy control; Korea Biobank Network; normal control | adult; Article; biobank; blood sampling; consensus; controlled study; human; hypercholesterolemia; Korea; standard | English | 2023 | 2023-04-24 | 10.3390/jcm12093080 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Cost-Effectiveness of All-Oral Regimens for the Treatment of Multidrug-Resistant Tuberculosis in Korea: Comparison With Conventional Injectable-Containing Regimens | Background: Regimens for the treatment of multidrug-resistant tuberculosis (MDR-TB) have been changed from injectable-containing regimens to all-oral regimens. The economic effectiveness of new all-oral regimens compared with conventional injectable-containing regimens was scarcely evaluated. This study was conducted to compare the cost-effectiveness between all-oral longer-course regimens (the oral regimen group) and conventional injectable -containing regimens (the control group) to treat newly diagnosed MDR-TB patients.Methods: A health economic analysis over lifetime horizon (20 years) from the perspective of the healthcare system in Korea was conducted. We developed a combined simulation model of a decision tree model (initial two years) and two Markov models (remaining 18 years, six-month cycle length) to calculate the incremental cost-effectiveness ratio (ICER) between the two groups. The transition probabilities and cost in each cycle were assumed based on the published data and the analysis of health big data that combined country-level claims data and TB registry in 2013-2018.Results: The oral regimen group was assumed to spend 20,778 USD more and lived 1.093 years or 1.056 quality-adjusted life year (QALY) longer than the control group. The ICER of the base case was calculated to be 19,007 USD/life year gained and 19,674 USD/QALY. The results of sensitivity analyses showed that base case results were very robust and stable, and the oral regimen was cost-effective with a 100% probability for a willingness to pay more than 21,250 USD/QALY. Conclusion: This study confirmed that the new all-oral longer regimens for the treatment of MDR-TB were cost-effective in replacing conventional injectable-containing regimens. | Park, Hae-Young; Kwon, Jin-Won; Kim, Hye-Lin; Kwon, Sun-Hong; Nam, Jin Hyun; Min, Serim; Oh, In-Sun; Bea, Sungho; Ha Choi, Sun | Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug D, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Sahmyook Univ, Coll Pharm, Seoul, South Korea; Sungkyunkwan Univ, Sch Pharm, Suwon, South Korea; Korea Univ, Div Big Data Sci, Sejong Campus, Sejong, South Korea; Sungkyunkwan Univ, Dept Biohlth Regulatory Sci, Suwon, South Korea; McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada; Kyungpook Natl Univ, Sch Med, Dept Internal Med, 807 Hoguk Ro, Daegu 41404, South Korea | ; Kim, Chang/G-5001-2015; Kwon, Sun-Hong/KFS-7860-2024 | 57203771734; 16202951700; 57203629752; 56010779700; 57193239694; 57783199300; 57204059049; 57222590269; 57199723585 | sunha20@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 21 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.26 | 2025-06-25 | 1 | 1 | Multidrug-Resistant Tuberculosis; Tuberculosis; Health Economics; Cost Analysis | TREATMENT OUTCOMES; BEDAQUILINE | Cost Analysis; Health Economics; Multidrug-Resistant Tuberculosis; Tuberculosis | Clinical Protocols; Cost-Benefit Analysis; Humans; Quality-Adjusted Life Years; Republic of Korea; Tuberculosis, Multidrug-Resistant; clinical protocol; cost benefit analysis; human; multidrug resistant tuberculosis; quality adjusted life year; South Korea | English | 2023 | 2023-04-24 | 10.3346/jkms.2023.38.e167 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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