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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Genomic and Phenotypic Characterization of Cutibacterium acnes Bacteriophages Isolated from Acne Patients | Cutibacterium acnes is a pathogen that can cause acne vulgaris, sarcoidosis, endodontic lesions, eye infections, prosthetic joint infections, and prostate cancer. Recently, bacteriophage (phage) therapy has been developed as an alternative to antibiotics. In this study, we attempted to isolate 15 phages specific to C. acnes from 64 clinical samples obtained from patients with acne vulgaris. Furthermore, we sequenced the genomes of these three phages. Bioinformatic analysis revealed that the capsid and tape measure proteins are strongly hydrophobic. To efficiently solubilize the phage particles, we measured the adsorption rate, one-step growth curve, and phage stability using an SMT2 buffer containing Tween 20. Here, we report the genotypic and phenotypic characteristics of the novel C. acnes-specific phages. | Kim, Shukho; Song, Hyesoon; Jin, Jong Sook; Lee, Weon Ju; Kim, Jungmin | Kyungpook Natl Univ, Dept Microbiol, Sch Med, Daegu 41944, South Korea; Anim & Plant Quarantine Agcy, Avian Dis Div, Gimcheon 39660, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu 41944, South Korea; Anim & Plant Quarantine Agcy, Ctr FMD Vaccine Res, Gimcheon 39660, South Korea | Kim, Shukho/AGG-1087-2022 | 24341187900; 57201093893; 22950662200; 24474659000; 57211297681 | shukhokim@knu.ac.kr;bumb007@hanmail.net;in75724@hanmail.net;weonju@knu.ac.kr;minkim@knu.ac.kr; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 11 | 8 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2022 | 4.8 | 23.2 | 1.59 | 2025-06-25 | 15 | 14 | Cutibacterium acnes; bacteriophage; phage therapy; hydrophobicity | ANNOTATION; INFECTION; ALIGNMENT; SEQUENCE; DATABASE; THERAPY; GENES; TOOL | bacteriophage; Cutibacterium acnes; hydrophobicity; phage therapy | English | 2022 | 2022-08 | 10.3390/antibiotics11081041 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Long-term outcomes of endoscopic resection followed by additional surgery after non-curative resection in undifferentiated-type early gastric cancer: a nationwide multi-center study | Background Undifferentiated-type early gastric cancer (UD EGC) shows lower curative resection rates after endoscopic submucosal dissection (ESD). Additional surgery is recommended after non-curative resection. We evaluated the long-term outcomes of ESD followed by additional surgery after non-curative resection in UD EGC compared to those for surgery as initial treatment. Methods We reviewed 1139 UD EGC patients who underwent ESD at 18 hospitals and 1956 patients who underwent surgery at two hospitals between February 2005 and May 2015. We enrolled 636 patients with non-curative ESD and 1429 surgery subjects beyond the curative ESD criteria. Among them, 133 patients with additional surgery after ESD (ESD + OP group) and 252 patients without additional surgery (ESD-only group) were matched 1:1 using propensity scores to patients with surgery as initial treatment (surgery group). Overall survival (OS) and recurrence-free survival (RFS) were compared. Results Signet ring cell carcinoma and poorly differentiated adenocarcinoma (PDA) were observed in 939 and 1126 cases, respectively. OS was significantly longer in the surgery group than in the ESD + OP group, especially for PDA. However, RFS was shorter in the ESD-only group than those in the ESD + OP and surgery groups. RFS did not differ significantly between the ESD + OP and surgery groups. Compared to the surgery group, the ESD-only and ESD + OP groups had an overall hazard ratio for RFS of 3.58 (95% confidence interval 1.44-8.88) and 0.46 (0.10-2.20), respectively. Conclusions ESD followed by additional surgery after non-curative resection showed comparable cancer-specific outcomes to initial surgery in UD EGC. | Kim, Jie-Hyun; Kim, Young-, II; Ahn, Ji Yong; Shin, Woon Geon; Yang, Hyo-Joon; Nam, Su Youn; Min, Byung-Hoon; Jang, Jae-Young; Lim, Joo Hyun; Lee, Wan Sik; Lee, Bong Eun; Joo, Moon Kyung; Park, Jae Myung; Lee, Hang Lak; Gweon, Tae-Geun; Park, Moo In; Choi, Jeongmin; Tae, Chung Hyun; Kim, Young-Woo; Park, Boram; Choi, I. I. Ju | Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Natl Canc Ctr, Ctr Gastr Canc, 323 Ilsan Ro, Goyang 10408, Gyeonggi, South Korea; Univ Ulsan, Asan Med Ctr, Dept Internal Med, Coll Med, Seoul, South Korea; Hallym Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Gastrointestinal Canc Ctr, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Gastroenterol, Daegu, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Sch Med, Seoul, South Korea; Kyung Hee Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Healthcare Res Inst, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea; Pusan Natl Univ, Dept Internal Med, Sch Med, Busan, South Korea; Korea Univ, Coll Med, Guro Hosp, Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, Dept Internal Med, Seoul St Marys Hosp, Seoul, South Korea; Hanyang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Incheon St Marys Hosp, Incheon, South Korea; Kosin Univ, Dept Internal Med, Coll Med, Busan, South Korea; Inje Univ, Sanggye Paik Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Natl Canc Ctr, Res Inst, Res Core Ctr, Biostat Collaborat Team, Goyang, South Korea | Kim, Jie-Hyun/Q-9061-2019; Kim, Seong Cheol/ABD-1493-2022; Ahn, Ji Yong/AGO-1695-2022; Kim, Yuriy/ABD-7016-2020; Lee, In/J-9324-2013; Kim, Young/J-5415-2012; Park, Jae Myung/AGK-6655-2022 | 49461401400; 57203809495; 36809017800; 13606883400; 57188930761; 55617028500; 7202932034; 57215881098; 55774506200; 57208140974; 36461131900; 35313509000; 8548758100; 7501478057; 55365094900; 8666034000; 55646404000; 35211966400; 57215377843; 55629622000; 7401471464 | cij1224@ncc.re.kr; | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | SURG ENDOSC | 0930-2794 | 1432-2218 | 36 | 3 | SCIE | SURGERY | 2022 | 3.1 | 23.2 | 1.87 | 2025-06-25 | 9 | 9 | Stomach neoplasms; Undifferentiated-type histology; Endoscopic mucosal resection; Surgery; Treatment outcome | Endoscopic mucosal resection; Stomach neoplasms; Surgery; Treatment outcome; Undifferentiated-type histology | Carcinoma, Signet Ring Cell; Endoscopic Mucosal Resection; Gastric Mucosa; Humans; Retrospective Studies; Stomach Neoplasms; Treatment Outcome; adult; Article; cancer surgery; clinical outcome; computer assisted tomography; controlled study; distant metastasis; early cancer; endoscopic mucosal resection; esophagogastroduodenoscopy; female; follow up; histology; human; hypertension; lymph vessel metastasis; major clinical study; male; middle aged; outcome assessment; overall survival; poorly differentiated adenocarcinoma; propensity score; recurrence free survival; retrospective study; signet ring carcinoma; stomach cancer; surgical margin; tumor depth; tumor volume; ulcer; clinical trial; multicenter study; pathology; signet ring carcinoma; stomach mucosa; stomach tumor; treatment outcome | English | 2022 | 2022-03 | 10.1007/s00464-021-08464-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Medical students' self-evaluation of character, and method of character education | Background As medical doctors must have a strong sense of ethics, character education is particularly important for them compared with other professions. This follow-up study aimed to establish the foundation for developing a character education program in medical schools by (1) conducting a survey among medical students on the self-assessment of one's character based on eight qualities (service and sacrifice, empathy and communication, care and respect, honesty and humility, responsibility and calling, collaboration and magnanimity, creativity and positivity, patience and leadership), the perceived importance of character, and satisfaction with character education at medical school, and (2) analyzing the usefulness of learning methods for acquiring character elements. It also aimed at verifying the (3) gender differences in self-evaluation of character elements, and (4) academic-year differences in the survey items. Methods Medical students' perceptions were identified through a questionnaire survey among 856 medical students from five South Korean medical schools. The questionnaire comprised items on the achievement level of the character element, importance of character in the medical curriculum, satisfaction with character education in medical schools, and the learning method's degree of helpfulness. Descriptive statistics, t-test, and one-way ANOVA were used to compare responses. Results The importance of eight-character qualities had high average scores, whereas the average scores for satisfaction with character education and achievement level were comparatively low. For the question on each learning method's helpfulness in gaining the eight-character qualities, the score of team-based learning activities was the highest, followed by club activities, relationships with peers, role modeling of professors, and course study. Regarding satisfaction with character education, male students gave higher scores than female students, manifesting a statistically significant difference. Regarding the importance of the character element in medical education, statistically significant differences existed based on academic year. Conclusion Medical students' perceptions of character education varied according to gender and academic year. They regarded character education highly but were unsatisfied with the current character education at medical schools. Thus, diverse character education curricula must be developed and implemented along with extra-curricular character programs. An effective approach to implementing character education can be discovered by verifying the differences in students' perceptions based on the character education courses in medical schools. | Hur, Yera; Yeo, Sanghee; Lee, Keumho | Hallym Univ, Coll Med, Inst Med Educ, Chunchon, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Ctr Med Educ, Daegu, South Korea; Korea Univ Technol & Educ, Ctr Liberal Arts, Cheonan, South Korea | ; HUR, YERA/AFP-1662-2022 | 7006336103; 23391520800; 57210887721 | april0401@hanmail.net; | BMC MEDICAL EDUCATION | BMC MED EDUC | 1472-6920 | 22 | 1 | SSCI;SCIE | EDUCATION & EDUCATIONAL RESEARCH;EDUCATION, SCIENTIFIC DISCIPLINES | 2022 | 3.6 | 23.2 | 0.75 | 2025-06-25 | 4 | 5 | Character; Medical students; Professional practice gaps; Self-assessment; Professionalism | ETHICS EDUCATION; PROFESSIONALISM; US | Character; Medical students; Professional practice gaps; Professionalism; Self-assessment | Curriculum; Diagnostic Self Evaluation; Education, Medical, Undergraduate; Female; Follow-Up Studies; Humans; Male; Schools, Medical; Self-Assessment; Students, Medical; achievement; adult; analysis of variance; article; controlled study; cooperation; curriculum; education; female; gender; human; human experiment; learning; major clinical study; male; medical education; medical school; medical student; perception; practice gap; professionalism; questionnaire; satisfaction; self evaluation; follow up; medical education; procedures; self evaluation | English | 2022 | 2022-04-13 | 10.1186/s12909-022-03342-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Non-Inferior Efficacy of Tenofovir Disoproxil to Tenofovir Disoproxil Fumarate in Virologically Suppressed Chronic Hepatitis B Patients | Purpose: Tenofovir disoproxil (TD), modified from tenofovir disoproxil fumarate (TDF), was developed as a salt-free formula-tion, removing fumarate to improve the ease of oral intake by reducing the tablet's size. We evaluated the maintenance of antiviral effects and overall safety profile of TD 245 mg after switching from TDF 300 mg in patients with chronic hepatitis B (CHB).Patients and Methods: CHB patients with HBV-DNA = 24 weeks of TDF therapy were enrolled. The primary efficacy endpoint was the HBV-DNA suppression rate (HBV-DNA <69 IU/mL) at week 48; We evaluated the non-inferiority (10% margin) of TD to TDF in terms of efficacy. Safety was assessed based on adverse events (AEs), laboratory tests, bone mineral density, and renal function abnormalities.Results: Overall, 189 subjects were randomized in a 2:1 ratio, and 117 and 66 subjects in the TD and TDF groups, respectively, completed the study. In the per-protocol set, the HBV-DNA suppression rate at week 48 was 99.1% and 100% in the TD and TDF groups, respectively. The lower limit of the 97.5% one-sided confidence interval for the intergroup difference in HBV-DNA suppression rate was -2.8%, which was greater than the prespecified margin of non-inferiority. The changes in creatinine clearance from baseline to week 48 was significantly less in the TD group and in the TDF group; -0.8 +/- 9.8 versus -2.4 +/- 12.8 mL/min, respectively (P=0.017).Conclusion: TD was non-inferior to TDF for maintaining viral suppression in CHB patients, showing the less decline of renal function. | Yim, Hyung Joon; Kim, Ji Hoon; Cho, Yong Kyun; Kweon, Young Oh; Cho, Hyun Chin; Hwang, Jae Seok; Lee, Changhyeong; Koh, Moon Soo; Baek, Yang-Hyun; Park, Young-Min; Lee, Jeong-Hoon; Kim, Seung Up; Kang, Min-Kyu; Park, Neung Hwa; Lee, June Sung; Chon, Young Eun; Cheon, Gab Jin; Chae, Hee Bok; Sohn, Joo Hyun; Lim, Young-Suk | Korea Univ, Coll Med, Dept Internal Med, Ansan Hosp, Seoul, South Korea; Korea Univ, Coll Med, Dept Internal Med, Guro Hosp, Seoul, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Gastroenterol & Hepatol,Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Gyeongsang Natl Univ, Sch Med, Dept Internal Med, Gyeongsang Natl Univ Hosp, Jinju, South Korea; Keimyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Daegu Catholic Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Dongguk Univ, Ilsan Hosp, Coll Med, Dept Internal Med, Goyang, South Korea; Dong A Univ, Dept Gastroenterol, Coll Med, Busan, South Korea; Bundang Jesaeng Gen Hosp, Dept Internal Med, Seongnam, South Korea; Bundang Jesaeng Gen Hosp, Hepatol Ctr, Seongnam, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Liver Res Inst, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Severance Hosp, Yonsei Liver Ctr, Seoul, South Korea; Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Internal Med, Coll Med, Ulsan, South Korea; Inje Univ, Ilsan Paik Hosp, Dept Internal Med, Coll Med, Goyang, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Internal Med, Seongnam, South Korea; Ulsan Univ, GangNeung Asan Hosp, Dept Med, Coll Med, Gangwon Do, South Korea; Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; Hanyang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Hanyang Univ, Guri Hosp, Guri, South Korea; Univ Ulsan, Liver Ctr, Asan Med Ctr, Dept Gastroenterol,Coll Med, 43 Gil 88,Olymp Ro, Seoul, South Korea | Kang, Min/U-8050-2018; Kim, Kyung/I-5501-2015; Lee, Jeong/J-5534-2019; Kim, Jung/L-9791-2019; Kim, Sun/L-4239-2013; Lim, Young-Suk/AFQ-5165-2022; 박, 진화/GYV-5685-2022 | 7005664934; 57328819200; 35261851400; 7004694832; 36866027100; 57205851488; 55784781600; 55390402400; 15844799800; 57226045370; 55936232200; 54933821200; 59142854300; 7202111836; 8429951900; 36089768300; 7003953934; 16433216300; 57222479854; 57226548822 | limys@amc.seoul.kr; | DRUG DESIGN DEVELOPMENT AND THERAPY | DRUG DES DEV THER | 1177-8881 | 16 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2022 | 4.8 | 23.2 | 0.33 | 2025-06-25 | 3 | 3 | viral DNA; bone density; antiviral agents; viral suppression | VIRUS INFECTION; DOUBLE-BLIND; ALAFENAMIDE; FIBROSIS; PHASE-3 | antiviral agents; bone density; viral DNA; viral suppression | Adenine; Antiviral Agents; Creatinine; DNA, Viral; Fumarates; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Tablets; Tenofovir; Treatment Outcome; Viral Load; alanine aminotransferase; aspartate aminotransferase; creatinine; tenofovir disoproxil; adenine; antivirus agent; creatinine; fumaric acid derivative; hepatitis B(e) antigen; tenofovir; virus DNA; adult; aged; albuminuria; antiviral activity; antiviral resistance; Article; chronic hepatitis B; comparative effectiveness; constipation; controlled study; creatinine clearance; drug design; drug efficacy; drug safety; drug substitution; dual energy X ray absorptiometry; fatigue; female; follow up; headache; hematuria; human; laboratory test; limit of detection; major clinical study; male; multicenter study; nausea; osteoporosis; patient compliance; patient safety; phase 4 clinical trial; pyuria; randomized controlled trial; rhinopharyngitis; seroconversion; sustained virologic response; case report; clinical trial; Hepatitis B virus; tablet manufacture; treatment outcome; virus load | English | 2022 | 2022 | 10.2147/dddt.s376821 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Pharmacokinetics and Pharmacodynamics of YYD601, a Dual Delayed-Release Formulation of Esomeprazole, Following Single and Multiple Doses in Healthy Adult Volunteers Under Fasting and Fed Conditions | Background: YYD601 was developed as a novel dual delayed release (DDR) formulation of esomeprazole to prolong the plasma esomeprazole concentration and extend the duration of acid suppression. Purpose: The pharmacokinetic (PK) and pharmacodynamics (PD) characteristics of YYD601 after single and multiple oral administrations were investigated in healthy Korean adults under fasting and fed conditions, and compared with the original esomeprazole capsule. Methods: In the single-center, randomized, open-label, parallel-design, two-period study, thirty two volunteers were enrolled into four dosing groups, including esomeprazole 40-mg (group A), YYD60130-mg (group B), YYD601 40-mg (group C), and YYD601 60-mg (group D) once daily for 5 days. Blood samples were collected for PK analysis, before and up to 24 h after dosing. For PD characteristics of YYD601, the percentages of time with intragastric pH > 4 over a 24-h period and during night-time following multiple oral administrations were evaluated. Results: A total of 27 subjects completed the study. YYD601 showed a dual-peak PK profile under fasting condition, with delayed T-max, compared with conventional formulation. There were no significant differences in the AUC values adjusted for dose between the three YYD601 dosage groups and the conventional esomeprazole 40 mg. The esomeprazole AUC following single and multiple administration decreased with food intake by approximately 33%. YYD601 showed a linear pharmacokinetic profile in the dose range studied. There was no statistically significant difference in increase in mean percentage of time with intragastric pH > 4 for 24-hour and during night-time between the three different doses of YYD601 and the conventional formulation. The treatments were well-tolerated during the study and no serious adverse events were observed. Conclusion: YYD601 30 mg has a comparable effect on gastric acid inhibition as conventional esomeprazole 40 mg following once daily oral administration. Single and multiple oral dosing of YYD601 up to 60 mg were safe and well-tolerated throughout the study. | Lee, Hae Won; Kang, Woo Youl; Jung, Wookjae; Gwon, Mi-Ri; Cho, Kyunghee; Yoon, Young-Ran; Seong, Sook Jin | Kyungpook Natl Univ, Sch Med, Dept Mol Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Clin Pharmacol, Daegu 41944, South Korea; Biocore Co Ltd, Analyt Res Div, Seoul 08511, South Korea | Yoon, Young-Ran/GLT-0172-2022 | 57202973823; 56816263900; 57218206353; 56035800800; 57211130109; 14629744500; 57211130049 | yry@knu.ac.kr;wintersj@knu.ac.kr; | DRUG DESIGN DEVELOPMENT AND THERAPY | DRUG DES DEV THER | 1177-8881 | 16 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2022 | 4.8 | 23.2 | 0.55 | 2025-06-25 | 5 | 5 | esomeprazole; dual delayed release; pharmacokinetics; pharmacodynamics | GASTROESOPHAGEAL-REFLUX DISEASE; INTRAGASTRIC ACID CONTROL; LANSOPRAZOLE 30 MG; RABEPRAZOLE 20 MG; DEXLANSOPRAZOLE MR; MANAGEMENT; OMEPRAZOLE; PROVIDES; ARTICLE; PANTOPRAZOLE | Dual delayed release; Esomeprazole; Pharmacodynamics; Pharmacokinetics | Administration, Oral; Adult; Area Under Curve; Cross-Over Studies; Esomeprazole; Fasting; Healthy Volunteers; Humans; Volunteers; esomeprazole; proton pump inhibitor; unclassified drug; yyd 601; esomeprazole; adult; area under the curve; Article; controlled study; delayed drug release; drug capsule; drug formulation; drug half life; drug safety; drug tolerability; fasting; feeding; human; human experiment; Korean (people); male; maximum concentration; normal human; pharmacodynamics; pharmacokinetics; prospective study; randomized controlled trial; crossover procedure; diet restriction; oral drug administration; volunteer | English | 2022 | 2022 | 10.2147/dddt.s338131 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Prediction model for curative endoscopic submucosal dissection of undifferentiated-type early gastric cancer | Background Endoscopic submucosal dissection (ESD) is an effective treatment for early gastric cancer (EGC); however, its curative resection rate is low for undifferentiated-type EGC. We developed and externally validated a prediction model for curative ESD of undifferentiated-type EGC. Methods In this cross-sectional study, we included 448 patients who underwent ESD for undifferentiated-type EGC at 18 hospitals in Korea between 2005 and 2015 in the development cohort and 1342 patients who underwent surgery at two hospitals in the validation cohort. A prediction model was developed using the logistic regression model. Results Endoscopic tumor size 1-2 cm (odds ratio [OR], 2.40; 95% confidence interval [CI] 1.54-3.73), tumor size > 2 cm (OR, 14.00; 95% CI 6.81-28.77), and proximal tumor location from the lower to upper third of the stomach (OR, 1.45; 95% CI 1.03-2.04) were independent predictors of non-curative ESD. A six-score prediction model was developed by assigning points to endoscopic tumor size > 2 cm (five points), tumor size 1-2 cm (two points), upper third location (two points), and middle third location (one point). The rate of curative ESD ranged from 70.6% (score 0) to 11.6% (score 5) with an area under the receiver operating characteristic curve (AUC) of 0.720 (95% CI 0.673-0.766). The model also showed good performance in the validation cohort (AUC, 0.775; 95% CI 0.748-0.803). Conclusions This six-score prediction model may help in predicting curative ESD and making informed decisions about the treatment selection between ESD and surgery for undifferentiated-type EGC. | Yang, Hyo-Joon; Joo, Moon Kyung; Park, Jae Myung; Ahn, Ji Yong; Jang, Jae-Young; Lim, Joo Hyun; Nam, Su Youn; Kim, Jie-Hyun; Min, Byung-Hoon; Lee, Wan-Sik; Lee, Bong Eun; Shin, Woon Geon; Lee, Hang Lak; Gweon, Tae-Geun; Park, Moo In; Choi, Jeongmin; Tae, Chung Hyun; Kim, Young-Il; Ryu, Keun Won; Choi, Il Ju | Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Div Gastroenterol,Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Gastrointestinal Canc Ctr, Seoul, South Korea; Korea Univ, Guro Hosp, Coll Med, Div Gastroenterol,Dept Internal Med, 148 Gurodong Ro, Seoul 08308, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, 222 Banpo Daero, Seoul 06591, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Div Gastroenterol,Dept Internal Med, Seoul, South Korea; Kyung Hee Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Healthcare Res Inst, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Gastroenterol, Daegu, South Korea; Yonsei Univ, Gangnam Severance Hosp, Coll Med, Div Gastroenterol,Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea; Chonnam Natl Univ, Med Sch, Dept Internal Med, Gwangju, South Korea; Pusan Natl Univ, Sch Med, Dept Internal Med, Busan, South Korea; Hallym Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Div Gastroenterol,Dept Internal Med, Incheon, South Korea; Kosin Univ, Coll Med, Dept Internal Med, Busan, South Korea; Inje Univ, Sanggye Paik Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Natl Canc Ctr, Res Inst & Hosp, Ctr Gastr Canc, Goyang, South Korea | ; Lee, In/J-9324-2013; Kim, Jie-Hyun/Q-9061-2019; Park, Jae Myung/AGK-6655-2022; Ahn, Ji Yong/AGO-1695-2022; Kim, Yuriy/ABD-7016-2020; Kim, Seong Cheol/ABD-1493-2022 | 57188930761; 35313509000; 8548758100; 36809017800; 57215881098; 55774506200; 55617028500; 49461401400; 7202932034; 57208140974; 36461131900; 13606883400; 7501478057; 55365094900; 8666034000; 55646404000; 35211966400; 57203809495; 55667555300; 7401471464 | latyrx@korea.ac.kr;parkjerry@catholic.ac.kr; | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | SURG ENDOSC | 0930-2794 | 1432-2218 | 36 | 2 | SCIE | SURGERY | 2022 | 3.1 | 23.2 | 0.83 | 2025-06-25 | 5 | 5 | Early gastric cancer; Undifferentiated-type histology; Endoscopic submucosal dissection; Curative resection; Risk assessment | LYMPH-NODE METASTASIS; LONG-TERM OUTCOMES; RESECTION; DISCREPANCY; SURGERY | Curative resection; Early gastric cancer; Endoscopic submucosal dissection; Risk assessment; Undifferentiated-type histology | Cross-Sectional Studies; Endoscopic Mucosal Resection; Gastric Mucosa; Humans; Republic of Korea; Retrospective Studies; Stomach Neoplasms; Treatment Outcome; adult; Article; cancer size; cancer surgery; clinical feature; cohort analysis; cross-sectional study; early cancer; endoscopic submucosal dissection; female; human; human tissue; major clinical study; male; multicenter study; predictive model; retrospective study; sex difference; smoking; stomach cancer; tumor depth; endoscopic mucosal resection; pathology; South Korea; stomach mucosa; stomach tumor; treatment outcome | English | 2022 | 2022-02 | 10.1007/s00464-021-08426-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Study | The impact of pretransplant and posttransplant alcohol consumption on outcomes in kidney transplant recipients (KTRs) is uncertain. Self-reported alcohol consumption was obtained at the time of transplant and 2 years after transplant in a prospective cohort study. Among 907 KTRs, 368 (40.6%) were drinkers at the time of transplant. Compared to non-drinkers, alcohol consumption did not affect the risk of death-censored graft failure (DCGF), biopsy-proven acute rejection (BPAR), cardiovascular events, or all-cause mortality. Compared to persistent non-drinkers, the development of DCGF, BPAR, cardiovascular events, all-cause mortality, or posttransplant diabetes mellitus was not affected by the alcohol consumption pattern (persistent, de novo, or stopped drinking) over time. However, de novo drinkers had a significantly higher total cholesterol (p < 0.001) and low-density lipoprotein cholesterol levels (p = 0.005) compared to persistent non-drinkers 5 years after transplant, and had significantly higher total cholesterol levels (p = 0.002) compared to the stopped drinking group 7 years after transplant, even after adjusting for the use of lipid-lowering agents, age, sex, and body mass index. Although pretransplant and posttransplant alcohol consumption were not associated with major outcomes in KTRs during the median follow-up of 6.0 years, a new start of alcohol use after KT results in a relatively poor lipid profile. | Jung, Hee-Yeon; Jeon, Yena; Huh, Kyu Ha; Park, Jae Berm; Kim, Myung-Gyu; Lee, Sik; Han, Seungyeup; Ro, Han; Yang, Jaeseok; Ahn, Curie; Cho, Jang-Hee; Park, Sun-Hee; Kim, Yong-Lim; Kim, Chan-Duck | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Yonsei Univ, Coll Med, Dept Surg, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Surg, Sch Med, Seoul, South Korea; Korea Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Chonbuk Natl Univ Hosp, Dept Internal Med, Jeonju, South Korea; Keimyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Gachon Univ, Gil Hosp, Dept Internal Med, Incheon, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea | Yang, Jae/LUW-8250-2024; Han, Seung Seok/HGD-2825-2022; Cho, Jang-hee/ABD-3534-2020; Jung, Hee-Yeon/AFB-8578-2022; Park, Sun-Hee/LMN-0033-2024; Kim, Yong-Lim/AGK-3172-2022 | 57196396467; 57209909350; 35183155900; 13605451500; 36183208900; 57192521521; 24281360600; 26538034700; 57212326527; 7201986669; 7403536291; 7501831741; 55633533600; 8558530700 | hy-jung@knu.ac.kr;drcdkim@knu.ac.kr; | TRANSPLANT INTERNATIONAL | TRANSPL INT | 0934-0874 | 1432-2277 | 35 | SCIE | SURGERY;TRANSPLANTATION | 2022 | 3.1 | 23.2 | 0.15 | 2025-06-25 | 2 | 1 | kidney transplantation; alcohol; all-cause mortality; biopsy-proven acute rejection; cardiovascular events; death-censored graft failure; low-density lipoprotein cholesterol; total cholesterol | INSULIN SENSITIVITY; CHOLESTEROL LEVELS; FUNCTION DECLINE; ALL-CAUSE; RISK; DISEASE; POPULATION; METABOLISM; MORTALITY; DRINKERS | alcohol; all-cause mortality; biopsy-proven acute rejection; cardiovascular events; death-censored graft failure; kidney transplantation; low-density lipoprotein cholesterol; total cholesterol | Alcohol Drinking; Cardiovascular Diseases; Cholesterol; Graft Rejection; Graft Survival; Humans; Kidney Transplantation; Lipids; Prospective Studies; Risk Factors; cholesterol; cyclosporine; everolimus; high density lipoprotein cholesterol; low density lipoprotein cholesterol; sirolimus; steroid; tacrolimus; triacylglycerol; adult; aged; alcohol consumption; Article; cardiovascular disease; cholesterol blood level; clinical trial; cohort analysis; controlled study; coronary artery bypass graft; diabetes mellitus; female; glomerulus filtration rate; graft failure; heart infarction; human; hypertension; immunosuppressive treatment; kidney graft; kidney transplantation; lipid fingerprinting; liver transplantation; low density lipoprotein cholesterol level; major clinical study; male; multicenter study; non-drinker; prospective study; retransplantation | English | 2022 | 2022-05-30 | 10.3389/ti.2022.10243 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | CONCEPTUAL COST ESTIMATION FRAMEWORK FOR MODULAR PROJECTS: A CASE STUDY ON PETROCHEMICAL PLANT CONSTRUCTION | Modularization, which allows for pre-assembly away from a construction site, has been known to be more cost-effective than stick-built; however, contractors have difficulty ascertaining the benefits and adopting it. Calculating the benefits and costs of adopting modularization precedes decision making. However, modular cost estimation is challenging since relevant information in the early stages of a project and historical data about industrial modularization both have limited availability. To solve this problem, this study developed a conceptual cost estimation framework for industrial modular projects by converting stick-built project information. The framework is composed of eight steps based on two approaches. This study conducted a case study to demonstrate the applicability of the framework, which compared the project cost of modularization scenarios 1 and 2 with that of the stick-built version of the ongoing project. In addition, the estimated modular cost was compared with the engineers' estimation to verify the accuracy of the framework. The contributions of this study are in identifying and quantifying the factors influencing the differences in cost between the modularization and stick-built versions, and developing the conceptual cost estimation framework for an industrial modular project. This framework is expected to support deciding on adopting modularization, budgeting, and project viability. | Choi, Younguk; Park, Chan Young; Lee, Changjun; Yun, Sungmin; Han, Seung Heon | Yonsei Univ, Dept Civil & Environm Engn, Seoul, South Korea; Kyungpook Natl Univ, Intelligent Construct Automat Ctr, Daegu, South Korea; Yeungnam Univ, Dept Civil Engn, Gyongsan, South Korea | Park, Chan/F-5696-2010 | 57462804400; 57190000674; 57195408712; 26222001400; 23004849600 | smyun@yu.ac.kr;shh6018@yonsei.ac.kr; | JOURNAL OF CIVIL ENGINEERING AND MANAGEMENT | J CIV ENG MANAG | 1392-3730 | 1822-3605 | 28 | 2 | SCIE | ENGINEERING, CIVIL | 2022 | 4.3 | 23.4 | 0.3 | 2025-06-25 | 5 | 5 | modularization; industrial modular projects; conceptual cost estimation; quantity-based estimation; Monte-Carlo simulation | MONTE-CARLO-SIMULATION; ESTIMATING MODEL; QUANTITY | Conceptual cost estimation; Industrial modular projects; Modularization; Monte-Carlo simulation; Quantity-based estimation | Budget control; Cost effectiveness; Cost estimating; Decision making; Modular construction; Monte Carlo methods; Petrochemical plants; Petrochemicals; Case-studies; Conceptual cost estimation; Construction sites; Cost effective; Industrial modular project; Modular programs; Modularizations; Modulars; Plant construction; Quantity-based estimation; Intelligent systems | English | 2022 | 2022 | 10.3846/jcem.2022.16234 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Developing extreme heat acclimation in Bemisia tabaci Mediterranean (Hemiptera: Aleyrodidae) | Bemisia tabaci Mediterranean (MED) is a highly invasive cryptic species complex found in the world's tropical, subtropical, and temperate regions. It is a severe pest of various crops and a vector of plant pathogenic viruses, particularly geminiviruses. Thermal acclimation of insects is a critical for the survival in unfavorable temperature condition. We observed that great survival rate of B. tabaci MED at the uncontrolled greenhouse which had fluctuating temperature condition (FTC) from 10 degrees C to 60 degrees C in spring and summer season. Our study showed that while B. tabaci MED reared under FTC for 10 weeks from April to June, its survival rate was gradually increased when heat shock was treated 50 degrees C for 0.5 h. In contrast, the same heat shock treatment was lethal in the colony reared under constant temperature condition (CTC) at the controlled insectary. After being acclimated, the lethal temperatures LT50, LT95, and LT100 under CTC were 47.7 degrees C, 50.1 degrees C, and 50.3 degrees C, whereas those under FTC were 59.8 degrees C, 62.7 degrees C, and 63.0 degrees C, respectively. In addition, we observed that the transcript levels of three investigated heat shock protein (HSP) genes (hsp20, hsp70, and hsp90) were lower under FTC than under CTC. This study suggests that B. tabaci MED retains high heat acclimation ability, making it tolerant of extreme thermal conditions. | Jhan, Pijush Kanti; Lee, Kyeong-Yeoll | Kyungpook Natl Univ, Coll Agr & Life Sci, Div Appl Biosci, Daegu 41566, South Korea; Noakhali Sci & Technol Univ, Dept Agr, Noakhali, Bangladesh; Kyungpook Natl Univ, Inst Plant Med, Daegu, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea | 57204901028; 57217153096 | leeky@knu.ac.kr; | ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY | ARCH INSECT BIOCHEM | 0739-4462 | 1520-6327 | 110 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;ENTOMOLOGY;PHYSIOLOGY | 2022 | 2.2 | 23.5 | 0.5 | 2025-06-25 | 4 | 4 | climate change; heat acclimation; temperature; thermal tolerance; whitefly | SHOCK-PROTEIN GENES; EXPRESSION PATTERNS; CLIMATE-CHANGE; TEMPERATURE; BIOTYPE; STRESS; THERMOTOLERANCE; TOLERANCE; FECUNDITY; RESPONSES | climate change; heat acclimation; temperature; thermal tolerance; whitefly | Acclimatization; Animals; Extreme Heat; Heat-Shock Proteins; Heat-Shock Response; Hemiptera; heat shock protein; acclimatization; animal; genetics; heat; heat shock response; Hemiptera; metabolism | English | 2022 | 2022-06 | 10.1002/arch.21890 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Development of raspberry Pi single-board computer architecture based ultra-compact optical coherence tomography | The main goal of this study is to develop an ultra-compact optical coherence tomography (OCT) system operated by a single-board computer to enhance its on-field applicability with superior user-friendliness and minimized system complexity. The conceptual breakthrough of this demonstration is the development of an OCT using a simple Raspberry Pi single-board computer architecture (RB-OCT) that works in a similar manner as the conventional OCT systems. The unique feature of the developed all-in-one RB-OCT system is the versatile ultra-compactness, comprising all key components of an OCT system. To further enhance the miniaturization, the micro-electromechanical system (MEMS) scanning unit, the entire optical configuration, and signal generating amplifier circuits were custom made to be compatible with Raspberry Pi single-board computer architecture. The dimensions of the developed system are 228 mm width, 168 mm length, and 107 mm depth with an approximate weight of 2 kg, including an image display. The software interface was developed using C++ based on Debian OS and configured using parallel programming with multi-threading. In vivo skin, ex vivo mouse cochlea, and fresh onion peels were used to evaluate the performance of the proposed system. Based on the feasibility study, this new type of single-board architecture OCT has potential merits over conventional OCT systems to be applied as a primary imaging device in various fields. | Cho, Hoseong; Kim, Pilun; Wijesinghe, Ruchire Eranga; Kim, Hyeree; Ravichandran, Naresh Kumar; Jeon, Mansik; Kim, Jeehyun | Kyungpook Natl Univ, Coll IT Engn, Sch Elect & Elect Engn, Daegu 41566, South Korea; LG Elect, Prod Engn Res Inst, 222 LG Ro Jinwi Myeon, Pyeongtaek Si 17790, Gyeonggi Do, South Korea; Univ Sri Jayewardenepura, Fac Technol, Dept Mat & Mech Technol, Pitipana 10200, Homagama, Sri Lanka; Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, Daegu 41566, South Korea; Korea Basic Sci Inst, Ctr Sci Instrumentat, Daejeon 34133, South Korea | RAVICHANDRAN, NARESH KUMAR/D-2190-2017; Wijesinghe, Ruchire/K-3797-2016 | 57209416599; 56967482800; 56018152300; 57209102795; 57125825900; 24171094000; 7601373350 | msjeon@knu.ac.kr;jeehk@knu.ac.kr; | OPTICS AND LASERS IN ENGINEERING | OPT LASER ENG | 0143-8166 | 1873-0302 | 148 | SCIE | OPTICS | 2022 | 4.6 | 23.5 | 0.62 | 2025-06-25 | 4 | 7 | Ultra-compact Optical Coherence Tomography; Raspberry Pi-OCT (RB-OCT); single-board computer architecture; Portable Biomedical Imaging System | HAND-HELD | Portable Biomedical Imaging System; Raspberry Pi-OCT (RB-OCT); single-board computer architecture; Ultra-compact Optical Coherence Tomography | C++ (programming language); Computer architecture; Computer software; Medical imaging; MEMS; Parallel programming; Architecture-based; Coherence tomography; Optical-; Portable biomedical imaging system; Raspberry pi-optical coherence tomography; Single board computers; Single-board computer architecture; Single-board computers; Tomography system; Ultra-compact optical coherence tomography; Optical tomography | English | 2022 | 2022-01 | 10.1016/j.optlaseng.2021.106754 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluation of Lethal and Sublethal Effects of Methyl Benzoate on the Generalist Predator Orius laevigatus (Fieber) | Methyl benzoate (MBe), a volatile organic molecule, has been shown to have insecticidal effects on a variety of agricultural, stored products, and urban arthropod pests in recent investigations. However, the toxicity of MBe against nontarget organisms has rarely been investigated. This study investigated the lethal and sublethal effects of MBe on the generalist predator Orius laevigatus (Fieber) (Hemiptera: Anthocoridae) via different exposure routes. This species is an important natural enemy of thrips, aphids, and mites in biological control programs globally. Acute toxicity bioassays conducted on O. laevigatus showed that the lethal median concentration (LC50) values of MBe for topical and residual toxicity were 0.73 and 0.94%, respectively, after 24 hr of exposure. Importantly, a sublethal concentration of MBe (LC30 = 0.51%) did not affect the survival and reproduction of O. laevigatus. In addition, prey consumption by O. laevigatus under different exposure conditions with varying densities of Aphis gossypii (Glover) (Hemiptera: Aphididae) adults demonstrated a good fit for a Type II functional response. The sublethal concentration of MBe did not affect the attack rate and handling time of O. laevigatus compared to untreated insects, nor did it affect the longevity and fecundity of O. laevigatus females. Thus, according to the International Organization for Biological Control, the sublethal MBe concentration for O. laevigatus is categorized as harmless and may be used in conjunction with this predator species for integrated control of many agricultural insect pests. | Mostafiz, Md Munir; Guncan, Ali; Lee, Kyeong-Yeoll | Kyungpook Natl Univ, Coll Agr & Life Sci, Div Appl Biosci, Daegu 41566, South Korea; Ordu Univ, Fac Agr, Dept Plant Protect, TR-52200 Ordu, Turkey; Kyungpook Natl Univ, Sustainable Agr Res Ctr, Gunwi 39061, South Korea | Mostafiz, Md. Munir/AAD-7664-2019; Guncan, Ali/H-5610-2011 | 57204895546; 6504231034; 57217153096 | leeky@knu.ac.kr; | JOURNAL OF ECONOMIC ENTOMOLOGY | J ECON ENTOMOL | 0022-0493 | 1938-291X | 115 | 6 | SCIE | ENTOMOLOGY | 2022 | 2.2 | 23.5 | 0.48 | 2025-06-25 | 4 | 3 | biopesticide; environmentally friendly; integrated pest management; natural enemy; sustainable agriculture | FRANKLINIELLA-OCCIDENTALIS; COLEOPTERA-COCCINELLIDAE; FUNCTIONAL-RESPONSE; ESSENTIAL OILS; PESTICIDES; THIAMETHOXAM; INSECTICIDES; TOXICITY; BEETLE; BUG | biopesticide; environmentally friendly; integrated pest management; natural enemy; sustainable agriculture | Animals; Aphids; Benzoates; Female; Heteroptera; Insecta; Thysanoptera; benzoic acid; methyl benzoate; animal; aphid; female; Heteroptera; insect; Thysanoptera | English | 2022 | 2022-12 | 10.1093/jee/toac137 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Identification of entomopathogenic fungus Metarhizium rileyi infested in fall armyworm in the cornfield of Korea, and evaluation of its virulence | The fall armyworm (FAW) Spodoptera frugiperda is an important invasive pest in Africa and Asia. It is a polyphagous pest with at least 353 recorded host plant species, including corn. Chemical control of this pest is unsuccessful because of a developed resistance and harmful effects on the environment. Entomopathogenic fungi are potential biological control agents for FAW. In this study, the native strain of Metarhizium rileyi (KNU-Ye-1), collected from a cornfield at Yeongcheon, Korea, was identified by morphological and molecular characterization. The susceptibility of the fourth-instar larvae of FAW to the native strain M. rileyi was examined in the laboratory. The results showed that the Korean strain of M. rileyi (KNU-Ye-1) was highly virulent to FAW larvae, causing 89% mortality 7 days posttreatment. Therefore, M. rileyi (KNU-Ye-1) identified in this study is highly valuable for the biological control of FAW in the field. | Acharya, Rajendra; Lee, Ji-Youn; Hwang, Hwal-Su; Kim, Min-Ki; Lee, Seung-Yeol; Jung, Hee-Young; Park, Ikju; Lee, Kyeong-Yeoll | Kyungpook Natl Univ, Coll Agr & Life Sci, Daegu, South Korea; Kyungpook Natl Univ, Grad Sch Plant Protect & Quarantine, Daegu, South Korea; Chilgokgun Agr Technol Ctr, Chilgok, South Korea; Gyeongbuk Agr Res & Extens Serv, Daegu, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu, South Korea | Lee, Hye Ah/ABC-8131-2021; Acharya, Rajendra/AAG-6838-2020 | 57210568049; 57877018200; 57204055221; 57226681143; 56106499600; 7403029383; 57200320797; 57217153096 | leeky@knu.ac.kr; | ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY | ARCH INSECT BIOCHEM | 0739-4462 | 1520-6327 | 111 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;ENTOMOLOGY;PHYSIOLOGY | 2022 | 2.2 | 23.5 | 0.75 | 2025-06-25 | 6 | 6 | biological control; climate change; invasive species; natural enemy; Spodoptera frugiperda | FRUGIPERDA LEPIDOPTERA-NOCTUIDAE; INSECTICIDE RESISTANCE; NOMURAEA-RILEYI; HOST PLANTS; FIELDS | biological control; climate change; invasive species; natural enemy; Spodoptera frugiperda | Animals; Larva; Metarhizium; Spodoptera; Virulence; animal; larva; Metarhizium; microbiology; Spodoptera; virulence | English | 2022 | 2022-12 | 10.1002/arch.21965 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Selection of stable reference genes for quantitative real-time PCR in the Varroa mite, Varroa destructor | To investigate the acaricide toxicity and resistance mechanisms in the Varroa mite, it is essential to understand the genetic responses of Varroa mites to acaricides, which are usually evaluated by transcriptional profiling based on quantitative real-time polymerase chain reaction (qPCR). In this study, to select reference genes showing consistent expression patterns regardless of the acaricide treatment or the type of tissue, Varroa mites treated with each of the three representative acaricides (coumaphos, fluvalinate, and amitraz) were processed for transcriptomic analysis, from which eight genes (NADH dehydrogenase [NADHD], glyceraldehyde-3-phosphate dehydrogenase [GAPDH], eukaryotic translation elongation factor 1 alpha 1 [eEF1A1], eukaryotic translation elongation factor 2 [eEF2], ribosomal protein L5 [RpL5], Actin, tubulin alpha-1D chain [alpha-tubulin], and Rab1) were selected as candidates. The transcription profiles of these genes, depending on the treatment of the three acaricides or across different tissues (cuticle, legs, gut/fat bodies, and synganglion), were analyzed using qPCR with four validation programs, BestKeeper, geNorm, NormFinder, and RefFinder. Following acaricide treatment, eEF1A1 and NADHD showed the least variation in their expression levels, whereas the expression levels of alpha-tubulin and RpL5 were the most stable across different tissue groups. Rab1/GAPDH and Actin/eEF2 showed the least stable expression patterns following acaricide treatments and across different tissues, respectively, requiring precautions for use. When vitellogenin gene expression was analyzed by different reference genes, its expression profiles varied significantly depending on the reference genes, highlighting the importance of proper reference gene use. Thus, it is recommended using eEF1A1 and NADHD as reference genes for the comparison of the effects of acaricide on the whole body, whereas alpha-tubulin and RpL5 are recommended for investigating the tissue-specific expression profiles of target genes. | Lee, Joonhee; Kim, Young H.; Kim, Kyungmun; Kim, Dongwon; Lee, Si H.; Kim, Sanghyeon | Seoul Natl Univ, Dept Agr Biotechnol, Entomol Program, 1 Gwanak Ro, Seoul 08826, South Korea; Kyungpook Natl Univ, Dept Appl Biol, Sangju, Gyeongbuk, South Korea; Kyungpook Natl Univ, Dept Ecol Sci, Sangju, Gyeongbuk, South Korea; RDA, Natl Inst Agr Sci, Div Apiculture, Dept Agr Biol, Wonju, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, 1 Gwanak Ro, Seoul 08826, South Korea | Lee, Sang/R-7470-2019 | 57562565200; 58516491300; 56590665400; 57402056900; 34872664900; 57203773859 | shlee22@snu.ac.kr;zlddh97@snu.ac.kr; | ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY | ARCH INSECT BIOCHEM | 0739-4462 | 1520-6327 | 110 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;ENTOMOLOGY;PHYSIOLOGY | 2022 | 2.2 | 23.5 | 0.75 | 2025-06-25 | 6 | 6 | acaricide; qPCR; reference gene; tissue; Varroa mite | REVERSE TRANSCRIPTION-PCR; BEES APIS-MELLIFERA; HOUSEKEEPING GENES; EXPRESSION; RESISTANCE; HONEYBEE; PROTEIN; RNA | acaricide; qPCR; reference gene; tissue; Varroa mite | Acaricides; Actins; Animals; Gene Expression Profiling; Real-Time Polymerase Chain Reaction; Tubulin; Varroidae; acaricide; actin; tubulin; animal; gene expression profiling; genetics; real time polymerase chain reaction; Varroidae | English | 2022 | 2022-07 | 10.1002/arch.21905 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Sub 100 nm resolution confocal focus-engineered coherent anti-Stokes Raman scattering microscopy under non-degenerate pumping condition | For the development of microscopic tools that can resolve non-fluorescent samples beyond the diffraction limit, we propose focus-engineered non-degenerate pumped coherent anti-Stokes Raman scattering (CARS) using spa-tial light modulator (SLM)-based phase shaping, liquid lens focus control, and confocal detection. Non-degenerate pumped CARS (ND-CARS) with frequency-doubled probe pulses resulted in approximately 75% improvement in resolution compared to that of degenerate CARS. Focal adjustment using the liquid lens facilitated the accurate overlapping of three beams. The circular pi-phase modulation at the center of the probe-beam wavefront demar-cated the net CARS focal volume into a sub 100 nm-scale core and surrounding side lobes. The confocal geometry detection setup successfully removed the side lobes, allowing optical imaging of 81 nm-sized zinc oxide particles at 87 nm, and edge-to-edge resolution was determined to be 103 nm. | Lee, Gwanjin; Jyothsna, Konkada Manattayil; Lim, Heejin; Park, Jonghoo; Lee, JaeDong; Raghunathan, Varun; Kim, Hyunmin | DGIST, Dept Phys & Chem, Daegu 42988, South Korea; Indian Inst Sci, Dept Elect Commun Engn, Bangalore, India; DGIST, Dept New Biol, Daegu 42988, Daegu, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; DGIST, Div Biotechnol, Daegu 42988, South Korea; DGIST, Interdisciplinary Studies, Daegu 42988, South Korea | Kim, Hyunmin/D-2875-2011 | 57759986400; 57211120709; 57200994073; 57196408322; 55689995600; 7006419981; 57192552925 | hyunmin.kim@dgist.ac.kr; | OPTICS AND LASERS IN ENGINEERING | OPT LASER ENG | 0143-8166 | 1873-0302 | 158 | SCIE | OPTICS | 2022 | 4.6 | 23.5 | 0.06 | 2025-06-25 | 1 | 2 | Sub-diffraction-limit nonlinear optical microscopy; Coherent anti-Stokes Raman spectroscopy; Nanoparticles | GENERATION; ZNO | Coherent anti-Stokes Raman spectroscopy; Nanoparticles; Sub-diffraction-limit nonlinear optical microscopy | Coherent scattering; Diffraction; II-VI semiconductors; Light modulators; Nanoparticles; Optical pumping; Probes; Raman scattering; Zinc oxide; Coherent anti Stokes Raman scattering; Coherent anti-Stokes Raman scattering microscopy; Coherent anti-stokes Raman spectroscopy; Liquid lens; Nm resolution; Nonlinear optical microscopy; Side lobes; Sub-100 nm; Sub-diffraction limit; Sub-diffraction-limit nonlinear optical microscopy; Raman spectroscopy | English | 2022 | 2022-11 | 10.1016/j.optlaseng.2022.107142 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Virtual intraoperative optical coherence tomography angiography integrated surgical microscope for simultaneous imaging of morphological structures and vascular maps in vivo | Intraoperative surgical microscopy integrated with optical coherence tomography (OCT) has improved the ac-curacy and safety of surgeries by providing a visualization of the sub-surface tissue structure. Although intraop-erative OCT has resolved the conventional limitations of the surgical microscope, it is still remained to pro -vide additional informative blood vessel-related data that is required to enhance the stability of surgery by minimizing bleeding and tissue damage. In this paper, we developed a virtual intraoperative OCT angiogra-phy integrated surgical microscope (VI-OCTA-SM) to simultaneously visualize morphological tissue structure and microvasculature data of the surgical region including tumor margin and blood vessel map. In addition, cross-sectional OCT and OCTA images and a three-dimensional maximum amplitude projection OCTA vascu-lar map are concurrently displayed on the ocular eyepiece by augmented reality. The results of VI-OCTA-SM-based in-vivo imaging of mouse tissue (ear and brain) with different magnifications confirmed the capabil-ity of the VI-OCTA-SM to perform microvasculature imaging of small animals with an adjustable lateral res-olution and scanning range according to the experimental conditions. Moreover, we successfully conducted melanoma resection as a simulated surgery following the guidance of the VI-OCTA-SM, which verified the appli-cability of the developed system to the surgical environment. Our proposed VI-OCTA-SM system has promising potential in various intraoperative applications including dermatological, ophthalmological, and neurological surgeries. | Seong, Daewoon; Ki, Won; Kim, Pilun; Lee, Jaeyul; Han, Sangyeob; Yi, Soojin; Kim, Hong Kyun; Jeon, Mansik; Kim, Jeehyun | Kyungpook Natl Univ, Coll IT Engn, Sch Elect & Elect Engn, Daegu 41566, South Korea; LG Elect, Prod Engn Res Inst, 222 LG Ro Jinwi Myeon, Pyeongtaek Si 17790, Gyeonggi Do, South Korea; Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA; Kyungpook Natl Univ, Inst Biomed Engn, Sch Med, Daegu 41566, South Korea; Kyungpook Natl Univ Hosp, Biomed Inst, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu 41944, South Korea | Lee, Junsoo/IUO-9627-2023 | 57212512353; 57396678400; 56967482800; 57188689420; 57193695305; 56783537100; 57218260940; 24171094000; 7601373350 | msjeon@knu.ac.kr; | OPTICS AND LASERS IN ENGINEERING | OPT LASER ENG | 0143-8166 | 1873-0302 | 151 | SCIE | OPTICS | 2022 | 4.6 | 23.5 | 1.06 | 2025-06-25 | 12 | 12 | Surgical microscope; Intraoperative optical coherence tomography; angiography; Optical coherence tomography; Optical coherence tomography angiography; Surgery guiding | DIGITAL-SUBTRACTION-ANGIOGRAPHY; GALVANOMETER SCANNER; OPERATING MICROSCOPE; INDOCYANINE GREEN; GUIDANCE; SURGERY; SYSTEM | Intraoperative optical coherence tomography angiography; Optical coherence tomography; Optical coherence tomography angiography; Surgery guiding; Surgical microscope | Augmented reality; Blood; Blood vessels; Microscopes; Optical tomography; Surgery; Tissue; In-vivo; Intra-operative; Intraoperative optical coherence tomography angiography; Micro-vasculature; Morphological structures; Optical coherence tomography angiography; Simultaneous imaging; Surgery guiding; Surgical microscopes; Tissue structure; Angiography | English | 2022 | 2022-04 | 10.1016/j.optlaseng.2021.106943 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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