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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Neo-Fs Index: A Novel Immunohistochemical Biomarker Panel Predicts Survival and Response to Anti-Angiogenetic Agents in Clear Cell Renal Cell Carcinoma | Simple Summary Although anti-angiogenetic agents (AAA) are mainstay treatments for clear cell renal cell carcinoma (ccRCC), there are very few histology-based predictive biomarkers applicable in routine clinical practice. Considering that frameshifts contribute to antitumor immunity and ccRCC harbors the highest indel proportion across tumors, we hypothesized that protein markers frequently mutated via frameshift indels could predict prognosis and response to AAA. We evaluated the prognostic impact of the individual protein markers and found five proteins showing independent prognostic value. Utilizing the five proteins, we developed an integrated biomarker-Neo-fs index. High Neo-fs index predicted better prognosis and AAA response. High Neo-fs index, which harbored greater single nucleotide variant and indel mutation, was also associated with antitumor immune gene signature. Neo-fs index could be a practical biomarker to improve risk stratification and predict AAA response in ccRCC patients. Background: Frameshift indels have emerged as a predictor of immunotherapy response but were not evaluated yet to predict anti-angiogenetic agent (AAA) response or prognosis in clear cell renal cell carcinoma (ccRCC). Methods: Here, to develop biomarkers that predict survival and response to AAA, we evaluated the immunohistochemical expression of proteins whose genes frequently harbor frameshift indels in 638 ccRCC patients and correlated the individual and integrated markers with prognosis and AAA response. The mutational landscape was evaluated using targeted next-generation sequencing in 12 patients concerning protein markers. Immune gene signatures were retrieved from TCGA RNA seq data. Results: Five proteins (APC, NOTCH1, ARID1A, EYS, and filamin A) were independent adverse prognosticators and were incorporated into the Neo-fs index. Better overall, disease-specific and recurrence-free survival were observed with high Neo-fs index in univariate and multivariate survival analyses. Better AAA responses were observed with a high Neo-fs index, which reflected increased MHC class I, CD8+ T cell, cytolytic activity, and plasmacytoid dendritic cell signatures and decreased type II-IFN response signatures, as well as greater single-nucleotide variant (SNV) and indel counts. Conclusions: Neo-fs index, reflecting antitumor immune signature and more SNVs. and indels, is a powerful predictor of survival and AAA response in ccRCC. | Kim, Jisup; Park, Jee-Young; Shin, Su-Jin; Lim, Beom Jin; Go, Heounjeong | Univ Ulsan, Dept Pathol, Asan Med Ctr, Coll Med, Seoul 05505, South Korea; Yonsei Univ, Dept Pathol, Coll Med, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Med Ctr, Daegu 41944, South Korea | Park, Jung Hwan/AAA-1951-2022; Kim, Dong Ki/J-5389-2012; Shin, Su-Jin/KPB-2645-2024 | 56703774500; 57226185359; 57189709813; 7201983912; 57204538826 | jspath@amc.seoul.kr;pathpjy@naver.com;charm@yuhs.ac;bjlim@yuhs.ac;damul37@amc.seoul.kr; | CANCERS | CANCERS | 2072-6694 | 13 | 6 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 0.28 | 2025-07-30 | 5 | 5 | clear cell renal cell carcinoma; frameshift insertion and deletion; immunohistochemical biomarker; anti-angiogenic agent response; prognosis | SYSTEMIC THERAPY; PD-1 BLOCKADE; TUMORS; NEOANTIGENS; SENSITIVITY; PHENOTYPE; FILAMIN; PROTEIN | Anti-angiogenic agent response; Clear cell renal cell carcinoma; Frameshift insertion and deletion; Immunohistochemical biomarker; Prognosis | APC protein; everolimus; filamin A; gamma interferon; major histocompatibility antigen class 1; Notch1 receptor; oncoprotein; pazopanib; protein ARID1A; protein EYS; sorafenib; sunitinib; temsirolimus; unclassified drug; adult; angiogenesis; Article; cancer prognosis; cancer survival; CD8+ T lymphocyte; controlled study; cytolysis; disease specific survival; female; gene expression; gene mutation; genetic variability; high throughput sequencing; human; human cell; immunohistochemistry; major clinical study; male; middle aged; overall survival; patient selection; phenotype; plasmacytoid dendritic cell; prediction; protein expression; recurrence free survival; renal cell carcinoma; retrospective study; RNA sequencing; single nucleotide polymorphism; treatment response; tumor immunity | English | 2021 | 2021-03 | 10.3390/cancers13061199 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Patient-Reported Outcomes of Regular Aerobic Exercise in Gastric Cancer | Simple Summary The benefits of exercise for health-related quality of life (HRQOL) and depression in patients with gastric cancer remain unclear. Thus this research was suggested to examine the association between maintenance of regular aerobic exercise at a recommended level and depression and HRQOL in patients with gastric cancer during or after treatment. The findings indicated that exercise can have a synergistic effect on improvement in HRQOL via indirect positive effects on depression and direct effects on HRQOL in patients with gastric cancer. The findings of this research may add the evidence on the benefits of exercise for HRQOL and depression in patients with gastric cancer to the research community. The benefits of exercise for health-related quality of life (HRQOL) and depression in patients with gastrointestinal disease remain unclear, and studies on gastric cancer are scant. This study examines the association between the maintenance of regular aerobic exercise at a recommended level and depression and HRQOL in patients with gastric cancer during or after treatment. In this cross-sectional study, a face-to-face survey was used to collect data from 126 patients with primary gastric cancer during or after treatment in a tertiary acute-care hospital in Korea. Regular exercise was defined as regularly maintained aerobic exercise of at least moderate intensity consuming >= 4 metabolic equivalents for >= 150 min/wk for at least 6 months. Depression was measured using the 9-item version of the Patient Health Questionnaire, and HRQOL was assessed using the EORTC QLQ-C30. Patients who maintained aerobic exercise at a recommended level were less likely to have depression and more likely to have improved global QOL, as well as physical, role, and emotional functioning. Patients with depression were less likely to report improved global QOL and functioning. Thus, exercise can have a synergistic effect on improvement in HRQOL via indirect positive effects on depression and direct effects on HRQOL in patients with gastric cancer. Oncology nurses should encourage patients with gastric cancer who suffer from a depressive mood to set up and implement specific plans for practicing regular exercise, which can lead to an improvement in both depression and HRQOL. | Lee, Myung-Kyung; Oh, Jihyun | Kyungpook Natl Univ, Res Inst Nursing Sci, Coll Nursing, Daegu 41944, South Korea; Daejeon Univ, Dept Nursing, Daejeon 34520, South Korea | 40661513200; 57207574572 | mlee@knu.ac.kr;grape0123@hanmail.net; | CANCERS | CANCERS | 2072-6694 | 13 | 9 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 0.62 | 2025-07-30 | 10 | 11 | exercise; depression; quality of life; gastric cancer | QUALITY-OF-LIFE; HOME-BASED EXERCISE; KOREAN VERSION; BREAST-CANCER; DEPRESSION; VALIDATION; CHEMOTHERAPY; POPULATION; FATIGUE; PROGRAM | Depression; Exercise; Gastric cancer; Quality of life | adult; aerobic exercise; aged; Article; controlled study; cross-sectional study; depression; emotionality; European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30; exercise intensity; female; health survey; human; major clinical study; male; metabolic equivalent; oncology nurse; outcome assessment; Patient Health Questionnaire 9; patient-reported outcome; quality of life; South Korea; stomach cancer; tertiary care center; therapy effect | English | 2021 | 2021-05 | 10.3390/cancers13092080 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | PBK/TOPK: An Effective Drug Target with Diverse Therapeutic Potential | Simple Summary Cancer is a major public health problem worldwide, and addressing its morbidity, mortality, and prevalence is the first step towards appropriate control measures. Over the past several decades, many pharmacologists have worked to identify anti-cancer targets and drug development strategies. Within this timeframe, many natural compounds have been developed to inhibit cancer growth by targeting kinases, such as AKT, AURKA, and TOPK. Kinase assays and computer modeling are considered to be effective and powerful tools for target screening, as they can predict physical interactions between small molecules and their bio-molecular targets. In the present review, we summarize the inhibitors and compounds that target TOPK and describe its role in cancer progression. The extensive body of research that has investigated the contribution of TOPK to cancer suggests that it may be a promising target for cancer therapy. T-lymphokine-activated killer cell-originated protein kinase (TOPK, also known as PDZ-binding kinase or PBK) plays a crucial role in cell cycle regulation and mitotic progression. Abnormal overexpression or activation of TOPK has been observed in many cancers, including colorectal cancer, triple-negative breast cancer, and melanoma, and it is associated with increased development, dissemination, and poor clinical outcomes and prognosis in cancer. Moreover, TOPK phosphorylates p38, JNK, ERK, and AKT, which are involved in many cellular functions, and participates in the activation of multiple signaling pathways related to MAPK, PI3K/PTEN/AKT, and NOTCH1; thus, the direct or indirect interactions of TOPK make it a highly attractive yet elusive target for cancer therapy. Small molecule inhibitors targeting TOPK have shown great therapeutic potential in the treatment of cancer both in vitro and in vivo, even in combination with chemotherapy or radiotherapy. Therefore, targeting TOPK could be an important approach for cancer prevention and therapy. Thus, the purpose of the present review was to consider and analyze the role of TOPK as a drug target in cancer therapy and describe the recent findings related to its role in tumor development. Moreover, this review provides an overview of the current progress in the discovery and development of TOPK inhibitors, considering future clinical applications. | Huang, Hai; Lee, Mee-Hyun; Liu, Kangdong; Dong, Zigang; Ryoo, Zeayoung; Kim, Myoung Ok | Kyungpook Natl Univ, ITRD, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; China US Henan Hormel Canc Inst, Zhengzhou 450008, Peoples R China; Dongshin Univ, Coll Korean Med, Naju 58245, Jeollanamdo, South Korea; Zhengzhou Univ, Dept Pathophysiol, Sch Basic Med Sci, Acad Med Sci,Coll Med, Zhengzhou 450001, Peoples R China; Kyungpook Natl Univ, Sch Life Sci, Daegu 41566, South Korea | 57215021952; 58960253600; 56890019100; 57225955964; 16937104900; 8934745900 | huanghai@knu.ac.kr;mhlee@dsu.ac.kr;kdliu@zzu.edu.cn;dongzg@zzu.edu.cn;jaewoong64@knu.ac.kr;ok4325@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 13 | 9 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 0.83 | 2025-07-30 | 24 | 30 | TOPK; cancer therapy; signaling pathway; inhibitors | ORIGINATED PROTEIN-KINASE; EPITHELIAL-MESENCHYMAL TRANSITION; PROTON-PUMP INHIBITOR; PDZ-BINDING KINASE; CELL LUNG-CANCER; NF-KAPPA-B; COLORECTAL-CANCER; INDUCED APOPTOSIS; TOPK PHOSPHORYLATION; MITOTIC KINASE | Cancer therapy; Inhibitors; Signaling pathway; TOPK | protein kinase; T lymphokine activated killer cell originated protein kinase; tumor marker; unclassified drug; apoptosis; autophagy (cellular); cancer chemotherapy; cancer prognosis; cell cycle; DNA damage; enzyme activity; enzyme regulation; human; malignant neoplasm; metastasis; nonhuman; overall survival; protein expression; protein interaction; protein targeting; Review; signal transduction; tumor cell; tumor growth | English | 2021 | 2021-05 | 10.3390/cancers13092232 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Predicting Tumor Budding Status in Cervical Cancer Using MRI Radiomics: Linking Imaging Biomarkers to Histologic Characteristics | Background: Our previous study demonstrated that tumor budding (TB) status was associated with inferior overall survival in cervical cancer. The purpose of this study is to evaluate whether radiomic features can predict TB status in cervical cancer patients. Methods: Seventy-four patients with cervical cancer who underwent preoperative MRI and radical hysterectomy from 2011 to 2015 at our institution were enrolled. The patients were randomly allocated to the training dataset (n = 48) and test dataset (n = 26). Tumors were segmented on axial gadolinium-enhanced T1- and T2-weighted images. A total of 2074 radiomic features were extracted. Four machine learning classifiers, including logistic regression (LR), random forest (RF), support vector machine (SVM), and neural network (NN), were used. The trained models were validated on the test dataset. Results: Twenty radiomic features were selected; all were features from filtered-images and 85% were texture-related features. The area under the curve values and accuracy of the models by LR, RF, SVM and NN were 0.742 and 0.769, 0.782 and 0.731, 0.849 and 0.885, and 0.891 and 0.731, respectively, in the test dataset. Conclusion: MRI-based radiomic features could predict TB status in patients with cervical cancer. | Chong, Gun Oh; Park, Shin-Hyung; Park, Nora Jee-Young; Bae, Bong Kyung; Lee, Yoon Hee; Jeong, Shin Young; Kim, Jae-Chul; Park, Ji Young; Ando, Yu; Han, Hyung Soo | Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41944, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Obstet & Gynecol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Clin Omics Res Ctr, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Cardiovasc Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu 41944, South Korea | ; Park, Shinhyung/LNQ-6428-2024 | 23099068000; 57203275843; 57226185359; 57191481610; 37088851700; 36164032500; 55719981700; 57210160197; 57295299200; 7401969388 | gochong@knu.ac.kr;shinhyungpark@knu.ac.kr;pathpjy@naver.com;bae1675@naver.com;mylyh@naver.com;syjeong@knu.ac.kr;jckim@knu.ac.kr;jyparkmd@knu.ac.kr;doyu94@daum.net;hshan@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 13 | 20 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 0.55 | 2025-07-30 | 11 | 11 | radiomics; cervical cancer; magnetic resonance imaging; tumor budding | CT TEXTURE ANALYSIS; SQUAMOUS-CELL CARCINOMA; COLORECTAL-CANCER; ESOPHAGEAL CANCER; PROGNOSTIC-FACTOR; RANDOMIZED-TRIAL; STAGE; HETEROGENEITY; RATIONALE; THERAPY | Cervical cancer; Magnetic resonance imaging; Radiomics; Tumor budding | tumor marker; adult; aged; Article; cancer classification; cancer staging; clinical evaluation; clinical feature; controlled study; female; histopathology; human; image analysis; image segmentation; machine learning; major clinical study; medical record review; nerve cell network; nuclear magnetic resonance imaging; preoperative period; prognostic assessment; radical hysterectomy; radiomics; random forest; retrospective study; support vector machine; tumor budding; uterine cervix cancer | English | 2021 | 2021-10 | 10.3390/cancers13205140 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Rethinking a Non-Predominant Pattern in Invasive Lung Adenocarcinoma: Prognostic Dissection Focusing on a High-Grade Pattern | Simple Summary Prognostic considerations for non-predominant histologic patterns are necessary because most lung adenocarcinomas have a mixed histologic pattern. We aimed to identify prognostic stratification by second most predominant pattern of lung adenocarcinomas and to more accurately assess prognostic factors with CT imaging analysis, particularly enhancing non-predominant but high-grade pattern. We confirmed that the second most predominant histologic pattern can stratify lung adenocarcinoma patients according to prognosis. Especially, when the second most predominant pattern was high-grade, recurrence risk increased by 4.2-fold compared with the low-grade group. Thus, predicting the malignant potential and establishing treatment policies should not rely only on the most predominant pattern. Also, imaging parameters of higher non-contrast CT value and higher SUVmax value are associated with non-predominant but high-grade histologic pattern. Background: Prognostic considerations for non-predominant patterns are necessary because most lung adenocarcinomas (ADCs) have a mixed histologic pattern, and the spectrum of actual prognosis varies widely even among lung ADCs with the same most predominant pattern. We aimed to identify prognostic stratification by second most predominant pattern of lung ADC and to more accurately assess prognostic factors with CT imaging analysis, particularly enhancing non-predominant but high-grade pattern. Methods: In this prospective study, patients with early-stage lung ADC undergoing curative surgery underwent preoperative dual-energy CT (DECT) and positron emission tomography (PET)/CT. Histopathology of ADC, the most predominant and second most predominant histologic patterns, and preoperative imaging parameters were assessed and correlated with patient survival. Results: Among the 290 lung ADCs included in the study, 231 (79.7%) were mixed-pathologic pattern. When the most predominant histologic pattern was intermediate-grade, survival curves were significantly different among the three second most predominant subgroups (p = 0.004; low, lepidic; intermediate, acinar and papillary; high, micropapillary and solid). When the second most predominant pattern was high-grade, recurrence risk increased by 4.2-fold compared with the low-grade group (p = 0.005). To predict a non-predominant but high-grade pattern, the non-contrast CT value of tumor was meaningful with a lower HU value associated with the histologic combination of lower grade (low-grade as most predominant and intermediate-grade as second most predominant pattern, OR = 6.15, p = 0.005; intermediate-grade as most predominant and high-grade as second most predominant pattern, OR = 0.10, p = 0.033). SUVmax of the tumor was associated with the non-predominant but high-grade pattern, especially in the histologic combination of intermediate-high grade (OR = 1.14, p = 0.012). Conclusions: The second most predominant histologic pattern can stratify lung ADC patients according to prognosis. Thus, predicting the malignant potential and establishing treatment policies should not rely only on the most predominant pattern. Moreover, imaging parameters of non-contrast CT value and SUVmax could be useful in predicting a non-predominant but high-grade histologic pattern. | Choi, Yeonu; Kim, Jonghoon; Park, Hyunjin; Kim, Hong Kwan; Kim, Jhingook; Jeong, Ji Yun; Ahn, Joong Hyun; Lee, Ho Yun | Sungkyunkwan Univ, Sch Med SKKU SOM, Dept Radiol, 81 Irwon Ro, Seoul 06351, South Korea; Sungkyunkwan Univ, Sch Med SKKU SOM, Samsung Med Ctr, Ctr Imaging Sci, 81 Irwon Ro, Seoul 06351, South Korea; Sungkyunkwan Univ, Dept Elect & Comp Engn, Suwon 16419, South Korea; Inst Basic Sci, Ctr Neurosci Imaging Res, Suwon 16419, South Korea; Sungkyunkwan Univ, Sch Med SKKU SOM, Samsung Med Ctr, Dept Thorac & Cardiovasc Surg, Seoul 06351, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu 41404, South Korea; Sungkyunkwan Univ, Sch Med SKKU SOM, Samsung Med Ctr, Data Sci Res Inst,Biomed Stat Ctr, Seoul 06351, South Korea; Sungkyunkwan Univ, SAIHST, Dept Hlth Sci & Technol, Seoul 06351, South Korea | Kim, Junpyo/HGD-2747-2022; Lee, Ho Yun/D-6086-2012; Park, Hyunjin/A-1164-2007; Kim, Hong/AAR-4892-2020 | 56610984900; 57214338837; 56512679000; 34968151200; 7601380132; 57205472984; 55224100800; 57192502540 | skyblue718@skku.edu;jhkim4915@skku.edu;hyunjinp@skku.edu;hkts@skku.edu;jkimsmc@skku.edu;jyjeong@knu.ac.kr;anter@skku.edu;hoyunlee@skku.edu; | CANCERS | CANCERS | 2072-6694 | 13 | 11 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 0.69 | 2025-07-30 | 16 | 16 | lung adenocarcinoma (ADC); heterogeneity; high-grade pattern; histology; prognosis; recurrence | POSITRON-EMISSION-TOMOGRAPHY; GLASS OPACITY NODULES; INTERNATIONAL-ASSOCIATION; IASLC/ATS/ERS CLASSIFICATION; COMPUTED-TOMOGRAPHY; HISTOLOGIC PATTERN; CT; SUBTYPE; LOBECTOMY; SYSTEM | Heterogeneity; High-grade pattern; Histology; Lung adenocarcinoma (ADC); Prognosis; Recurrence | adult; Article; cancer grading; cancer patient; cancer prognosis; cancer survival; computer assisted tomography; controlled study; demography; disease free survival; dual energy computed tomography; female; health care policy; histology; histopathology; human; lung adenocarcinoma; lung surgery; major clinical study; male; maximum standardized uptake value; middle aged; population structure; positron emission tomography; prediction; preoperative period; prospective study; recurrence risk | English | 2021 | 2021-06 | 10.3390/cancers13112785 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Rhein Suppresses Colorectal Cancer Cell Growth by Inhibiting the mTOR Pathway In Vitro and In Vivo | Simple Summary Colorectal cancer (CRC) is the fourth most common cancer and the second most common cause of cancer-related deaths globally. Rhein is a natural anthraquinone extract from rhubarb, which exhibits potent anticancer activity in various cancers. In this study, we show that rhein significantly inhibited the growth, migration, and invasion of CRC cells by directly binding to mTOR and inhibiting the mTOR signaling pathway. Rhein promotes mTOR degradation through the ubiquitin-proteasome pathway. In addition, rhein significantly suppressed tumor growth in a xenograft mouse model without obvious toxicity. Our results indicate that rhein is a promising anticancer agent that may be useful for the prevention and treatment of CRC. Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world. Rhein has demonstrated therapeutic effects in various cancer models. However, its effects and underlying mechanisms of action in CRC remain poorly understood. We investigated the potential anticancer activity and underlying mechanisms of rhein in CRC in vitro and in vivo. Cell viability and anchorage-independent colony formation assays were performed to examine the antigrowth effects of rhein on CRC cells. Wound-healing and Transwell assays were conducted to assess cell migration and invasion capacity. Cell cycle and apoptosis were investigated by flow cytometry and verified by immunoblotting. A tissue microarray was used to detect mTOR expression in CRC patient tissues. Gene overexpression and knockdown were done to analyze the function of mTOR in CRC. The anticancer effect of rhein in vivo was assessed in a CRC xenograft mouse model. The results show that rhein significantly inhibited CRC cell growth by inducing S-phase cell cycle arrest and apoptosis. Rhein inhibited CRC cell migration and invasion through the epithelial-mesenchymal transition (EMT) process. mTOR was highly expressed in CRC cancer tissues and cells. Overexpression of mTOR promoted cell growth, migration, and invasion, whereas mTOR knockdown diminished these phenomena in CRC cells in vitro. In addition, rhein directly targeted mTOR and inhibited the mTOR signaling pathway in CRC cells. Rhein promoted mTOR degradation through the ubiquitin-proteasome pathway. Intraperitoneal administration of rhein inhibited HCT116 xenograft tumor growth through the mTOR pathway. In conclusion, rhein exerts anticancer activity in vitro and in vivo by targeting mTOR and inhibiting the mTOR signaling pathway in CRC. Our results indicate that rhein is a potent anticancer agent that may be useful for the prevention and treatment of CRC. | Zhang, Haibo; Yi, Jun-Koo; Huang, Hai; Park, Song; Park, Sijun; Kwon, Wookbong; Kim, Eungyung; Jang, Soyoung; Kim, Si-Yong; Choi, Seong-Kyoon; Kim, Sung-Hyun; Liu, Kangdong; Dong, Zigang; Ryoo, Zae Young; Kim, Myoung Ok | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, ITRD, Sangju 37224, South Korea; Gyeongbuk Livestock Res Inst, Yeongju 36052, South Korea; DGIST, Core Prot Resources Ctr, Daegu 41566, South Korea; DGIST, Dept Brain & Cognit Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, BK21 FOUR KNU Creat Bioresearch, Sch Life Sci, Daegu 41566, South Korea; DGIST, Div Biotechnol, Daegu 41566, South Korea; Korea Polytech Coll, Dept Biomed Anal, Chungnam 34134, South Korea; China US Henan Hormel Canc Inst, Zhengzhou 450008, Peoples R China | ; Yi, Junkoo/JBR-8507-2023; Zhang, Haibo/HLP-9266-2023; RYOO, ZAEYOUNG/AAQ-1573-2020 | 57221648126; 56182537200; 57215021952; 57139047900; 54682212300; 57139843600; 57217871658; 57139360300; 57212197751; 55505432500; 59103241900; 56890019100; 57225955964; 16937104900; 8934745900 | 2018326925@knu.ac.kr;79lee38@korea.kr;huanghai@knu.ac.kr;stemsj@knu.ac.kr;cristaling@dgist.ac.kr;bongdaling@dgist.ac.kr;kge99777@knu.ac.kr;jangsy@knu.ac.kr;kim_si-yong@knu.ac.kr;cskbest@dgist.ac.kr;shkim92@kopo.ac.kr;kdliu@zzu.edu.cn;zgdong@hi.umm.edu;jaewoong64@knu.ac.kr;ok4325@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 13 | 9 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 1.45 | 2025-07-30 | 23 | 24 | Rhein; colorectal cancer; mTOR; xenograft | SHOCK FACTOR-1 HSF1; S-PHASE ARREST; HEAT-SHOCK; DOWN-REGULATION; POOR-PROGNOSIS; EXPRESSION; INITIATION; DEGRADATION; RECURRENCE; AUTOPHAGY | Colorectal cancer; MTOR; Rhein; Xenograft | cycloheximide; mammalian target of rapamycin; rhein; ubiquitin protein ligase; anchorage independent growth; animal cell; animal experiment; animal model; animal tissue; antineoplastic activity; apoptosis; Article; cell cycle; cell cycle arrest; cell proliferation; cell viability; colony formation; colorectal cancer; controlled study; down regulation; drug efficacy; drug potency; epithelial mesenchymal transition; human; human cell; ID50; immunofluorescence; in vitro study; in vivo study; male; microscopy; mouse; mTOR signaling; nonhuman; protein cleavage; protein degradation; protein expression; protein stability; tissue microarray; tumor volume; ubiquitination; Western blotting | English | 2021 | 2021-05 | 10.3390/cancers13092176 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comprehensive Lists of Internal Calibrants for Ultrahigh-Resolution Mass Spectrometry Analysis of Crude Oil and Natural Organic Matter and Their Preparation Recipes | In this work, comprehensive lists of internal calibrants for accurate mass determination of molecules in crude oils, natural organic matter, and soil as well as their preparation recipes are presented. The lists include various sets of chemicals for positive- and negative-ion mode electrospray ionization, atmospheric pressure chemical ionization, atmospheric pressure photoionization, and laser desorption ionization. The chemicals were chosen based on their solvent compatibility, ionization efficiency, and accessibility. The sample preparation process was optimized for each ionization method and type of sample. The lists include detailed information on preparation solvent, concentrations, and mixing ratios of sample and calibrants. Internal calibration using the information in the lists results in successful calibration, and all the data presented in this study show root-mean-square errors between the theoretical and obtained m/z numbers of less than 0.4 ppm. The information presented in this study provides an important guideline for researchers working on complex mixtures with ultrahigh-resolution mass spectrometry. | Cho, Eunji; Solihat, Nissa Nurfajrin; Kim, Young Hwan; Kim, Sunghwan | Kyungpook Natl Univ, Mass Spectrometry Based Convergence Res Inst, Daegu 41566, South Korea; Indonesian Inst Sci LIPI, Res Ctr Biomat, Cibinong 16911, Indonesia; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Green Nano Mat Res Ctr, Daegu 41566, South Korea; Korea Basic Sci Inst, Ctr Res Equipment, Cheongju 28119, Chungcheongbuk, South Korea; Chungnam Natl Univ, Grad Sch Analyt Sci & Technol, Daejeon 34134, South Korea | Kim, Sunghwan/HKN-9812-2023; Solihat, Nissa/GVT-7174-2022; Kim, Young Hwan/AAA-5484-2022 | 55863428700; 57199653322; 57007547300; 57203772967 | yhkim@kbsi.re.kr;sunghwank@knu.ac.kr; | JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | J AM SOC MASS SPECTR | 1044-0305 | 1879-1123 | 32 | 2 | SCIE | BIOCHEMICAL RESEARCH METHODS;CHEMISTRY, ANALYTICAL;CHEMISTRY, PHYSICAL;SPECTROSCOPY | 2021 | 3.262 | 24.4 | 0.93 | 2025-07-30 | 13 | 13 | Atmospheric chemistry; Atmospheric ionization; Atmospheric pressure; Biogeochemistry; Calibration; Crude oil; Drug products; Indicators (chemical); Mass spectrometry; Mean square error; Negative ions; Organic compounds; Petroleum analysis; 2 propanol; 9 anthroic acid; acetonitrile; arginine; heptadecanoic acid; methanol; natural organic matter; petroleum; stearic acid; Atmospheric pressure chemical ionization; Atmospheric pressure photo ionization; Internal calibration; Ionization efficiency; Laser desorption ionization; Natural organic matters; Root mean square errors; Ultrahigh resolution mass spectrometries; Article; atmospheric pressure; calibration; fourier transform ion cyclotron resonance mass spectrometry; ionization; mass spectrometry; negative ion electrospray; positive ion electrospray; Electrospray ionization | English | 2021 | 2021-02-03 | 10.1021/jasms.0c00456 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Accuracy of Portable Face-Scanning Devices for Obtaining Three-Dimensional Face Models: A Systematic Review and Meta-Analysis | The use of three-dimensional face-scanning systems to obtain facial models is of increasing interest, however, systematic assessments of the reliability of portable face-scan devices have not been widely conducted. Therefore, a systematic review and meta-analysis were performed considering the accuracy of facial models obtained by portable face-scanners in comparison with that of those obtained by stationary face-scanning systems. A systematic literature search was conducted in electronic databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for articles published from 1 January 2009 to 18 March 2020. A total of 2806 articles were identified, with 21 articles available for the narrative review and nine studies available for meta-analysis. The meta-analysis revealed that the accuracy of the digital face models generated by the portable scanners was not significantly different from that of the stationary face-scanning systems (standard mean difference (95% confidence interval) = -0.325 mm (-1.186 to 0.536); z = -0.74; p = 0.459). Within the comparison of the portable systems, no statistically significant difference was found concerning the accuracy of the facial models among scanning methods (p = 0.063). Overall, portable face-scan devices can be considered reliable for obtaining facial models. However, caution is needed when applying face-scanners with respect to scanning device settings, control of involuntary facial movements, landmark and facial region identifications, and scanning protocols. | Mai, Hang-Nga; Kim, Jaeil; Choi, Youn-Hee; Lee, Du-Hyeong | Kyungpook Natl Univ, Inst Translat Res Dent, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prevent Dent, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu 41940, South Korea | ; Mai, Hang-Nga/Q-9865-2018 | 56964780900; 57211615348; 7404777239; 35770948000 | mai.hang.nga1403@gmail.com;jaeilkim@knu.ac.kr;cyh1001@knu.ac.kr;deweylee@knu.ac.kr; | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | INT J ENV RES PUB HE | 1660-4601 | 18 | 1 | SCIE;SSCI | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 4.614 | 24.5 | 0.74 | 2025-07-30 | 24 | 28 | accuracy; three-dimensional face model; portable facial scanning; systematic review; meta-analysis | FACIAL ANATOMY; REPRODUCIBILITY; RELIABILITY; VALIDATION; PHOTOGRAMMETRY | Accuracy; Meta-analysis; Portable facial scanning; Systematic review; Three-dimensional face model | Automated Facial Recognition; Databases, Factual; Face; Humans; Reproducibility of Results; accuracy assessment; equipment; literature review; meta-analysis; reliability analysis; three-dimensional modeling; face; human; meta analysis; narrative; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; review; systematic review; devices; factual database; reproducibility | English | 2021 | 2021-01 | 10.3390/ijerph18010094 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Adsorptive Removal of Arsenic and Lead by Stone Powder/Chitosan/Maghemite Composite Beads | Arsenic (As) and lead (Pb) contamination in groundwater is a serious problem in countries that use groundwater as drinking water. In this study, composite beads, called SCM beads, synthesized using stone powder (SP), chitosan (Ch), and maghemite (Mag) with different weight ratios (1/1/0.1, 1/1/0.3, and 1/1/0.5 for SP/Ch/Mag) were prepared, characterized and used as adsorbents for the removal of As and Pb from artificially contaminated water samples. Adsorption isotherm experiments of As and Pb onto the beads were conducted and single-solute adsorption isotherm models such as the Langmuir, Freundlich, Dubinin-Radushkevich (DR), and dual mode (DM) models were fitted to the experimental data to analyze the adsorption characteristics. The maximum adsorption capacities of the SCM beads were 75.7 and 232.8 mmol/kg for As and Pb, respectively, which were 40 and 5.6 times higher than that of SP according to the Langmuir model analyses. However, the DM model had the highest determinant coefficient (R-2) values for both As and Pb adsorption, indicating that the beads had heterogenous adsorption sites with different adsorption affinities. These magnetic beads could be utilized to treat contaminated groundwater. | Pak, Hun; Phiri, Jesse; We, Junhyung; Jung, Kyungho; Oh, Sanghwa | Kyungpook Natl Univ, Sch Architectural Civil Environm & Energy Engn, Daegu 41566, South Korea | 57237676300; 57236845700; 57236565100; 57211004544; 26665620700 | ph6524@knu.ac.kr;jesset.phiri@knu.ac.kr;gud6417@knu.ac.kr;nabi6030@daum.net;shoh@knu.ac.kr; | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | INT J ENV RES PUB HE | 1660-4601 | 18 | 16 | SCIE;SSCI | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 4.614 | 24.5 | 0.63 | 2025-07-30 | 11 | 11 | arsenic; lead; maghemite; chitosan; stone powder; bead; adsorption | AQUEOUS-SOLUTION; IRON-OXIDE; SORPTION; EQUILIBRIUM; WATER; GOETHITE; KINETICS; PB(II); IONS; GROUNDWATER | Adsorption; Arsenic; Bead; Chitosan; Lead; Maghemite; Stone powder | Adsorption; Arsenic; Chitosan; Ferric Compounds; Hydrogen-Ion Concentration; Kinetics; Lead; Powders; Water Pollutants, Chemical; Water Purification; aluminum; arsenic; calcium; carbon; chitosan; chlorine; drinking water; ferric oxide; ground water; iron; lead; magnesium; nitrogen; oxygen; phosphorus; potassium; silicon; sodium; talc; ferric ion; ferric oxide; lead; adsorption; arsenic; composite; experimental study; groundwater pollution; lead; maghemite; pollutant removal; adsorption; adsorption isotherm; adsorptive removal; Article; Brunauer Emmett Teller method; centrifugation; Dual mode model; Dubinin Radushkevich model; energy dispersive X ray spectroscopy; enthalpy; entropy; field emission scanning electron microscopy; Fourier transform infrared spectroscopy; Freundlich model; gibbs free energy; heavy metal removal; isotherm; Langmuir model; model; particle size; partition coefficient; pH; physical parameters; pore size; thermodynamics; water contamination; kinetics; powder; water management; water pollutant | English | 2021 | 2021-08 | 10.3390/ijerph18168808 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Analysis of Superspreading Potential from Transmission Clusters of COVID-19 in South Korea | The COVID-19 pandemic has been spreading worldwide with more than 246 million confirmed cases and 5 million deaths across more than 200 countries as of October 2021. There have been multiple disease clusters, and transmission in South Korea continues. We aim to analyze COVID-19 clusters in Seoul from 4 March to 4 December 2020. A branching process model is employed to investigate the strength and heterogeneity of cluster-induced transmissions. We estimate the cluster-specific effective reproduction number R-eff and the dispersion parameter ? using a maximum likelihood method. We also compute R-m as the mean secondary daily cases during the infection period with a cluster size m. As a result, a total of 61 clusters with 3088 cases are elucidated. The clusters are categorized into six groups, including religious groups, convalescent homes, and hospitals. The values of R-eff and ? of all clusters are estimated to be 2.26 (95% CI: 2.02-2.53) and 0.20 (95% CI: 0.14-0.28), respectively. This indicates strong evidence for the occurrence of superspreading events in Seoul. The religious groups cluster has the largest value of R-eff among all clusters, followed by workplaces, schools, and convalescent home clusters. Our results allow us to infer the presence or absence of superspreading events and to understand the cluster-specific characteristics of COVID-19 outbreaks. Therefore, more effective suppression strategies can be implemented to halt the ongoing or future cluster transmissions caused by small and sporadic clusters as well as large superspreading events. | Lee, Hyojung; Han, Changyong; Jung, Jooyi; Lee, Sunmi | Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea; Kyung Hee Univ, Dept Appl Math, Yongin 17104, South Korea; Korea Univ, Dept Biostat, Seoul 02841, South Korea | Han, Chang/AAI-8376-2020 | 57196021198; 7403379281; 57362853200; 55716483800 | hjlee@knu.ac.kr;cyhan@khu.ac.kr;wjdwndl8113@naver.com;sunmilee@khu.ac.kr; | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | INT J ENV RES PUB HE | 1660-4601 | 18 | 24 | SCIE;SSCI | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 4.614 | 24.5 | 0.7 | 2025-07-30 | 9 | 11 | SARS-CoV-2; COVID-19; statistical model; superspreading events; cluster-induced transmissions; cluster-specific reproduction number | Cluster-induced transmissions; Cluster-specific reproduction number; COVID-19; SARS-CoV-2; Statistical model; Superspreading events | COVID-19; Disease Outbreaks; Humans; Pandemics; Republic of Korea; SARS-CoV-2; Seoul [South Korea]; South Korea; SARS coronavirus; COVID-19; disease spread; disease transmission; numerical model; religion; statistical analysis; workplace; Article; coronavirus disease 2019; dispersion; effective reproduction number; home; hospital; human; pandemic; religious group; school; South Korea; superspreading event; virus transmission; workplace; epidemic; epidemiology | English | 2021 | 2021-12 | 10.3390/ijerph182412893 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Association between Periodontal Health and Stroke: Results from the 2013-2015 Korea National Health and Nutrition Examination Survey (KNHANES) | Background/purpose: As the population ages, the prevalence of stroke increases, and as such there has been increasing interest in the risk factors associated with stroke. Although an association between periodontitis and stroke has been suggested, there has been no study of this association among the Korean population. Therefore, we investigated the association between periodontal health and stroke among Korean adults. Materials and methods: A total of 9497 adults aged >= 40 years representing the Korean population were included in this cross-sectional study from the Korea National Health and Nutrition Examination Survey (KNHANES) VI (2013-2015). Periodontitis was diagnosed by dentists based on the Community Periodontal Index (CPI). Also, participants filled out a questionnaire regarding their experience of doctor-diagnosed stroke. Hypertension, diabetes, body mass index (BMI), and oral hygiene behavior covariates were adjusted in logistic regression analysis. Results: The mean age of the study population was 55.7 +/- 10.17 years and 52.7% of them were female. Also, 248 people had a history of having a stroke. Results of the logistic regression analysis after adjusting for age and sex showed a significant relationship between oral health behavior, periodontal health, and stroke even after adjusting for age, sex, education, household income, national health insurance, employment status, alcohol, smoking, diabetes, hypertension, BMI, and oral health behaviors (odds ratio [OR], 1.71; 95% confidence interval [CI] = 1.03-2.85). Conclusion: Our findings suggest that periodontitis is associated with stroke in Korean adults. (C) 2020 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V. | Cho, Min-Jeong; Kim, Young-Seok; Park, Eun Young; Kim, Eun-Kyong | Kyungpook Natl Univ, Dept Dent Hyg, Coll Sci & Technol, 2559 Gyeongsangde Ro, Sangju, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Dept Prevent Dent, Sch Dent, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Dent, Daegu, South Korea | Kim, Jeong Ho/AAA-7538-2022 | 57201842940; 56091925200; 57188575494; 55915892100 | jinha01@naver.com; | JOURNAL OF DENTAL SCIENCES | J DENT SCI | 1991-7902 | 2213-8862 | 16 | 1 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2021 | 3.719 | 24.5 | 1.59 | 2025-07-30 | 10 | 11 | Oral hygiene; Periodontitis; Stroke | TOOTH LOSS; RISK; HYPERTENSION; ATHEROSCLEROSIS; HISTORY; DISEASE | Oral hygiene; Periodontitis; Stroke | English | 2021 | 2021-01 | 10.1016/j.jds.2020.05.006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Associations between Mental Health and Oral Health among Korean Adolescents: Analysis of the National Surveys (2008-2017) | We aimed to analyze the trends and associations between the oral and mental health of Korean adolescents using the Korea Youth Risk Behavior Web-based Surveys. In total, 713,713 adolescents who participated in the surveys were included. To examine trends in oral and mental health, Pearson's correlation coefficients were calculated between the weighted percentages and years, and the regression line slope was assessed to estimate annual changes. A complex sample logistic regression analysis was also performed. Experiencing oral symptoms and suicide-related factors both showed a gradually decreasing trend from 2008 and slight increases in 2017 and 2016, respectively. Compared with adolescents who had no oral symptoms, those with all six oral symptoms showed an increase in suicide attempts in the last 12 months, suicide ideation, and feelings of sadness and despair. In conclusion, experiencing more oral symptoms is associated with an increased risk of suicide-related factors. | Lee, Kyeong-Hee; Lee, Won-Kee; Jung, Eun-Seo; Choi, Yoon-Young | Shinhan Univ, Coll Bioecol Hlth, Dept Dent Hyg, Uijongbu 11644, South Korea; KyungPook Natl Univ, Sch Med, Dept Med Informat, Daegu 41944, South Korea | Choi, Yoonyoung/AAP-5711-2020 | 57208239842; 22953484700; 57208244881; 57208238348 | khlee@shinhan.ac.kr;wonlee@knu.ac.kr;dentalmien@hanmail.net;dencyy@naver.com; | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | INT J ENV RES PUB HE | 1660-4601 | 18 | 20 | SCIE;SSCI | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 4.614 | 24.5 | 0.21 | 2025-07-30 | 3 | 3 | adolescents; mental health; national survey; oral health; suicide attempt; suicide ideation | Adolescents; Mental health; National survey; Oral health; Suicide attempt; Suicide ideation | Adolescent; Adolescent Behavior; Depression; Humans; Mental Health; Oral Health; Republic of Korea; Risk Factors; Suicidal Ideation; Surveys and Questionnaires; Korea; mental health; oral health; risk factor; suicide; symptom; young population; adolescence; adolescent; Article; comparative study; female; gingiva bleeding; gingiva pain; halitosis; health status; hopelessness; human; Korean (people); major clinical study; male; mental health; mouth; mouth disease; risk factor; sadness; suicidal ideation; suicide; suicide attempt; tongue disease; tongue pain; tooth fracture; tooth pain; trend study; adolescent behavior; depression; epidemiology; health; questionnaire; South Korea | English | 2021 | 2021-10 | 10.3390/ijerph182010660 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Comparison of Interface Pressures and Subjective Comfort of Pressure-Relieving Overlays on the Operating Table for Healthy Volunteers | (1) Background: Pressure ulcers in the hospital setting occurring within 72 h after surgery are called perioperative pressure injuries. The aim of this study was to provide data for the prevention of perioperative pressure injuries following the use of pressure-relieving overlays by measuring the interface pressures and subjective comfort. (2) Methods: This study is based on a repeated measures design. The subjects included 30 healthy volunteers aged 18 to 57 years. Interface pressures of the sacrum and both heels were measured in the supine position, and the subjective comfort was evaluated with visual analog scale after applying polyurethane foam, gel pad, and egg crate foam for relief. (3) Results: The pressures in the sacrum and both heels were the lowest with polyurethane foam, and the subjective comfort was the highest. (4) Conclusions: Inexpensive polyurethane foam with satisfactory pressure relief is recommended as an overlay for surgical patients. | Han, Min Jung; Ko, Sangjin | Kyungpook Natl Univ Hosp, Daegu 41944, South Korea; Univ Ulsan, Dept Nursing, Ulsan 44610, South Korea | 57222241830; 57189035848 | rngemini@naver.com;sangjinko@ulsan.ac.kr; | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | INT J ENV RES PUB HE | 1660-4601 | 18 | 5 | SCIE;SSCI | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 4.614 | 24.5 | 0.14 | 2025-07-30 | 3 | 3 | pressure ulcer; operating tables; perioperative nursing; pressure; sacrum; heel | Heel; Operating tables; Perioperative nursing; Pressure; Pressure ulcer; Sacrum | Adolescent; Adult; Beds; Healthy Volunteers; Heel; Humans; Lower Extremity; Middle Aged; Operating Tables; Pressure Ulcer; Young Adult; gel; polyurethan foam; hospital sector; medicine; polymer; adult; Article; comfort; controlled study; female; foam; heel; human; human experiment; interface pressure; male; normal human; sacrum; South Korea; supine position; surgical patient; visual analog scale; adolescent; bed; decubitus; lower limb; middle aged; operating table; young adult | English | 2021 | 2021-03 | 10.3390/ijerph18052640 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Diagnostic Evaluation and Preparation of the Reference Information for River Restoration in South Korea | We assessed the naturalness of rivers based on the riparian vegetation index throughout the national territory of South Korea as a preparatory process for restoration to improve the ecological quality of rivers. The riparian vegetation index was obtained by incorporating the diversity of species and community, vegetation profile, and ratios of the number of species and areas occupied by exotic, obligate upland, and annual plants. The evaluation was conducted based on both the riparian vegetation index and each vegetation component. The result of the evaluation based on the riparian vegetation index showed that more than 70% of the river reaches were graded as less than "moderate" and exotic and obligate upland plants were more common than endemic aquatic plants. The reaches recorded as "very good" and "good" grades were usually restricted around the upstream of the north and central-eastern parts, whereas reaches of the other areas showed "poor" naturalness (less than "moderate"). The vegetation components selected for the evaluation showed a significant correlation with each other as well as the riparian vegetation index. The degree of contribution of each vegetation component showed that the vegetation profile played the most significant role, followed by species diversity, community diversity, and the ratio of area occupied by annual plants. The riparian vegetation index revealed a significant correlation with the indices based on other taxa such as benthic invertebrates, periphytic algae, and fish, habitat conditions in the waterway, and water quality based on biochemical oxygen demand (BOD). The diagnostic evaluation results imply that most reaches need ecological restoration. The reference information was prepared by incorporating the vegetation condition with the highest score in each reach in the diagnostic evaluation. The river reach was divided into five reaches of upper and lower valley streams, upstream, midstream, and downstream. Information on the reference vegetation for restoration was prepared with the stand profile including both horizontal and vertical arrangements of riparian vegetation and species composition classified by the reach divided into five types. The levels of restoration were determined based on the diagnostic evaluation results. The lower the naturalness grade, the higher the level of restorative treatment was recommended. | Lim, Chi Hong; Pi, Jeong Hoon; Kim, A. Reum; Cho, Hyun Je; Lee, Kyu Song; You, Young Han; Lee, Kye Han; Kim, Kee Dae; Moon, Jeong Suk; Lee, Chang Seok | Natl Inst Ecol, Seocheon 33657, South Korea; Korea Natl Baekdudaegan Aboretum, Bonghwa 36209, South Korea; Seoul Womens Univ, Dept Bio & Environm Technol, Seoul 01797, South Korea; Kyungpook Natl Univ, Sch Forest Sci & Landscape Architecture, Daegu 41566, South Korea; Gangnung Wonju Univ, Dept Biol, Kangnung 25457, South Korea; Kongju Natl Univ, Dept Biol, Kong Ju 32588, South Korea; Chonnam Natl Univ, Dept Forest Resources, Gwangju 61186, South Korea; Korea Natl Univ Educ, Dept Environm Educ, Cheongju 28173, South Korea; Natl Inst Environm Res, Incheon 22689, South Korea | ; Lee, Chang/AAR-1697-2020 | 56625452600; 37067710800; 57196153229; 59792527000; 36987921600; 36643092900; 7501508901; 54412507900; 57197858178; 55700519000 | sync03@nie.re.kr;ecopjh@korea.kr;dkfma@swu.ac.kr;jhj132@hanmail.net;leeks84@gwnu.ac.kr;youeco21@kongju.ac.kr;khL@jnu.ac.kr;kdkim@knue.ac.kr;waterfa@korea.kr;leecs@swu.ac.kr; | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | INT J ENV RES PUB HE | 1660-4601 | 18 | 4 | SCIE;SSCI | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 4.614 | 24.5 | 0.7 | 2025-07-30 | 10 | 12 | diagnostic evaluation; reference river information; restoration; riparian vegetation; river type | ECOLOGICAL ASSESSMENT; RIPARIAN; INDICATORS; STREAMS; MACROINVERTEBRATES; QUALITY; PERSPECTIVE; MACROPHYTES; INTEGRITY; FRAMEWORK | Diagnostic evaluation; Reference river information; Restoration; Riparian vegetation; River type | Animals; Ecosystem; Invertebrates; Republic of Korea; Rivers; Water Quality; South Korea; Invertebrata; annual variation; community composition; restoration ecology; riparian vegetation; species diversity; species richness; alga; annual plant; article; biochemical oxygen demand; controlled study; habitat; human; invertebrate; nonhuman; South Korea; species composition; species diversity; stream (river); vegetation; water quality; animal; ecosystem; river; South Korea | English | 2021 | 2021-02 | 10.3390/ijerph18041724 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of Different Software Programs on the Accuracy of Dental Scanner Using Three-Dimensional Analysis | This in vitro study aimed to evaluate the 3D analysis for complete arch, half arch, and tooth preparation region by using four analysis software programs. The CAD reference model (CRM; N = 1 per region) and CAD test models (CTMs; N = 20 per software) of complete arch, half arch, and tooth preparation were obtained by using scanners. For both CRM and CTMs, mesh data other than the same area were deleted. For 3D analysis, four analysis software programs (Geomagic control X, GOM Inspect, Cloudcompare, and Materialise 3-matic) were used in the alignment of CRM and CTMs as well as in the 3D comparison. Root mean square (RMS) was regarded as the result of the 3D comparison. One-way analysis of variance and Tukey honestly significant difference tests were performed for statistical comparison of four analysis software programs (alpha = 0.05). In half-arch and tooth preparation region, the four analysis software programs showed a significant difference in RMS values (p < 0.001), but in complete-arch region, no significant difference was found among the four software programs (p = 0.139). As the area of the virtual cast for 3D analysis becomes smaller, variable results are obtained depending on the software program used, and the difference in results among software programs are not considered in the 3D analysis for complete-arch region. | Son, Keunbada; Lee, Wan-Sun; Lee, Kyu-Bok | Kyungpook Natl Univ, Grad Sch, Dept Dent Sci, Daegu 41940, South Korea; Kyungpook Natl Univ, Adv Dent Device Dev Inst A3DI, Daegu 41940, South Korea; Busan Inst Sci & Technol, Dept Dent Technol, 88 Srang Ro,132 Beon Gil, Busan 616737, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu 41940, South Korea | Son, Keunbada/AAG-8089-2019; SON, Keunbada/AAG-8089-2019 | 57202916520; 56103762800; 15925571200 | sonkeunbada@gmail.com;ws.lee@bist.ac.kr;kblee@knu.ac.kr; | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | INT J ENV RES PUB HE | 1660-4601 | 18 | 16 | SCIE;SSCI | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 4.614 | 24.5 | 2.24 | 2025-07-30 | 37 | 41 | 3D analysis; 3D comparison; alignment; 3D dental scanner; accuracy; dentistry | TOOTH PREPARATION; REGISTRATION; DESIGN | 3D analysis; 3D comparison; 3D dental scanner; Accuracy; Alignment; Dentistry | Computer-Aided Design; Imaging, Three-Dimensional; Software; accuracy assessment; public health; software; three-dimensional modeling; tooth; analysis of variance; article; clinical article; dental surgery; dentistry; software; computer aided design; software; three-dimensional imaging | English | 2021 | 2021-08 | 10.3390/ijerph18168449 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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