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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | A novel integrated CO2capture and direct methanation process using Ni/CaO catal-sorbents | A novel integrated CO(2)capture and utilization (CCU) process for direct methanation was proposed to reduce the total required thermal energy by effectively combining CO(2)capture and conversion using a Ni/CaO catal-sorbent. Compared to the conventional carbonation/decarbonation process, carbonated Ni/CaO catal-sorbents were regenerated by converting captured CO(2)to CH(4)under a H(2)atmosphere at temperatures lower than those required for CO(2)desorption. According to the theoretical and experimental results, the optimum reaction temperature for the novel CCU process was determined at 500 degrees C; while the Ni/CaO catal-sorbent exhibited high CO(2)capture and direct methanation capacity without sintering during consecutive cycle tests at 500 degrees C. Therefore, this new integrated CCU process for direct methanation could be a cost- and energy-effective approach to CH(4)production and climate emergency mitigation. | Jo, Seong Bin; Woo, Jin Hyeok; Lee, Jong Heon; Kim, Tae Young; Kang, Hu In; Lee, Soo Chool; Kim, Jae Chang | Kyungpook Natl Univ, Res Inst Adv Energy Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea | ; Jo, SeongBin/MFJ-9000-2025; Kim, Yu/L-8480-2017 | 57190754848; 57215492471; 57218697910; 57208461628; 57218699605; 8524020100; 55382762400 | soochool@knu.ac.kr;kjchang@knu.ac.kr; | SUSTAINABLE ENERGY & FUELS | SUSTAIN ENERG FUELS | 2398-4902 | 4 | 9 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 6.367 | 24.4 | 2.42 | 2025-06-25 | 77 | 76 | TEMPERATURE CO2 SORBENTS; DUAL FUNCTION MATERIALS; CAO-BASED SORBENTS; CARBON-DIOXIDE; FLUE-GAS; SOLID SORBENTS; CAPTURE; CONVERSION; TECHNOLOGY; SYSTEM | Calcium compounds; Carbon dioxide; Hydrogenation; Methanation; Sintering; Sorbents; CO2 capture; Cycle tests; Effective approaches; H2 atmosphere; Optimum reaction temperature; carbon dioxide; cost-benefit analysis; energy efficiency; experimental study; methane; reaction kinetics; Nickel compounds | English | 2020 | 2020-09-01 | 10.1039/d0se00760a | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | An organic-inorganic composite separator for preventing shuttle effect in lithium-sulfur batteries | Recently, lithium-sulfur batteries (LSBs) have been highlighted as next-generation batteries due to the high theoretical capacity of the sulfur nonmetal and Li metal. However, LSBs are difficult to be commercialized because of the continuous capacity fading phenomenon derived from the shuttle effect of lithium polysulfide. Herein, a novel organic-inorganic composite separator composed of poly(vinylidene fluoride-co-hexafluoropropylene) and anodic aluminum oxide is proposed to overcome these limitations. The proposed separator strongly reduces the dissolution issue of lithium polysulfide and considerably limits the movement of polysulfide. Moreover, it improves the stability of the lithium metal anode by evenly distributing the flux of lithium ions. Also, it shows excellent thermal stability and good electrolyte wettability. Therefore, the ionic conductivity shows a high value of more than 1 mS cm(-1), and the coulombic efficiency is over 99%. The LSBs assembled with the composite separator exhibit the maintained specific capacity over of 75% after 100 cycles at 0.5C. | Cho, Jinil; Ahn, Yong-keon; Gong, Yong Jun; Pyo, Seonmi; Yoo, Jeeyoung; Kim, Youn Sang | Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Program Nano Sci & Technol, 1 Gwanak Ro, Seoul 08826, South Korea; Konkuk Univ, Dept Energy Engn, 120 Neungdong Ro, Seoul 05029, South Korea; Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea; Seoul Natl Univ, Sch Chem & Biol Engn, Coll Engn, Seoul 08826, South Korea; Adv Inst Convergence Technol, 864-1 Iui Dong, Suwon 16229, Gyeonggi Do, South Korea | ; Cho, Hyuk/AAU-7753-2020; Kim, SoW/ABB-7917-2021; Yoo, Jeeyoung/AAH-1359-2019 | 57209801309; 56643866400; 57203432769; 57211858131; 56046607500; 8938854200 | jyoo@knu.ac.kr; | SUSTAINABLE ENERGY & FUELS | SUSTAIN ENERG FUELS | 2398-4902 | 4 | 6 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 6.367 | 24.4 | 0.38 | 2025-06-25 | 7 | 8 | ELECTROCHEMICAL CHARACTERIZATION; IONIC-CONDUCTIVITY; ENERGY-STORAGE; METAL ANODES; LI/S BATTERY; POLYSULFIDE; ELECTROLYTE; MECHANISM; MEMBRANE; BEHAVIOR | Alumina; Aluminum oxide; Anodic oxidation; Electrolytes; Fluorine compounds; Lithium compounds; Lithium-ion batteries; Polysulfides; Separators; Anodic aluminum oxide; Capacity fading; Coulombic efficiency; Lithium metal anode; Organic-inorganic composite; Poly(vinylidene fluoride-co-hexafluoropropylene); Specific capacities; Theoretical capacity; aluminum oxide; composite; electrode; electrolyte; energy storage; inorganic matter; lithium; organic matter; separation; sulfur; Lithium sulfur batteries | English | 2020 | 2020-06-01 | 10.1039/d0se00123f | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Anin situformed LiF protective layer on a Li metal anode with solvent-less cross-linking | Lithium metal is considered the most promising anode material because of its highest theoretical capacity and lowest electrode potential among the candidate materials. However, Li metal batteries have not been commercialized yet owing to their poor cycle stability. To solve this problem, many studies have reported that the addition of chemically stable LiF to the artificial solid electrolyte interphase (SEI) layer can effectively inhibit the low irreversibility of and dendrite growth on Li metal. However, this measure is inadequate for achieving the desired performance, and it introduces difficulties in the fabrication process. This study employs anin situLiF protective layer (PL) to stabilize the surface of Li metal. This artificial SEI layer that includes LiF can be fabricated simply through thermal curing of an F-rich material on the surface of Li metal. This "in situLiF PL" effectively prevents volume expansion of Li metal, resulting in a capacity retention of 52.1% after 1000 cycles at 5.0C. The proposed artificial SEI layer design offers an alternative strategy for stabilizing the surface of Li metal. | Kim, Hyunjin; Kim, Youn Sang; Yoo, Jeeyoung | Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Program Nano Sci & Technol, Seoul 151744, South Korea; Adv Inst Convergence Technol, 864-1 Iui Dong, Suwon 443270, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea | ; Yoo, Jeeyoung/AAH-1359-2019; Kim, SoW/ABB-7917-2021 | 59564809200; 8938854200; 56046607500 | jyoo@knu.ac.kr; | SUSTAINABLE ENERGY & FUELS | SUSTAIN ENERG FUELS | 2398-4902 | 4 | 7 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 6.367 | 24.4 | 0.93 | 2025-06-25 | 28 | 28 | RECHARGEABLE BATTERIES; GRAPHITE ELECTRODE; ION BATTERIES; LITHIUM; CHALLENGES; SALTS | Anodes; Lithium compounds; Seebeck effect; Solid electrolytes; Candidate materials; Capacity retention; Electrode potentials; Fabrication process; Protective layers; Solid electrolyte interphase layer (SEI); Theoretical capacity; Volume expansion; chemical binding; chemical composition; electrode; electrolyte; in situ measurement; inhibition; lithium; solvent; theoretical study; Lithium | English | 2020 | 2020-07-01 | 10.1039/d0se00357c | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | CO2 green technologies in CO2 capture and direct utilization processes: methanation, reverse water-gas shift, and dry reforming of methane | CO2 green technologies, such as methanation, reverse water-gas shift (rWGS), and dry reforming of methane (DRM), in CO2 capture and direct utilization processes are proposed to reduce the total thermal energy by effectively combining CO2 capture and conversion using Ni/CaO catal-sorbents. Compared to conventional calcium looping using CaO-based sorbents, carbonated Ni/CaO catal-sorbents are completely regenerated at lower temperatures by simultaneously converting the captured CO2 into chemicals via methanation, rWGS, or DRM. At optimum temperatures and concentrations of the feed gas (H-2 or CH4), the Ni/CaO catal-sorbents show excellent CO2 capture capacity and productivity. In addition, the structural variation of the Ni/CaO catal-sorbents is elucidated. Based on these theoretical and experimental studies, the novel integrated CO2 capture and direct utilization processes can be a promising technology to produce chemicals as well as mitigate CO2 levels from large-scale sources. | Jo, Seong Bin; Woo, Jin Hyeok; Lee, Jong Heon; Kim, Tae Young; Kang, Hu In; Lee, Soo Chool; Kim, Jae Chang | Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA; Kyungpook Natl Univ, Res Inst Adv Energy Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea | Kim, Yu/L-8480-2017; Jo, SeongBin/MFJ-9000-2025 | 57190754848; 57215492471; 57218697910; 57208461628; 57218699605; 8524020100; 55382762400 | soochool@knu.ac.kr;kjchang@knu.ac.kr; | SUSTAINABLE ENERGY & FUELS | SUSTAIN ENERG FUELS | 2398-4902 | 4 | 11 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 6.367 | 24.4 | 2.69 | 2025-06-25 | 80 | 80 | FUNCTIONAL CATALYTIC MATERIALS; DUAL FUNCTION MATERIALS; CAO-BASED SORBENTS; CARBON-DIOXIDE; SOLID SORBENTS; CONVERSION; STABILITY; NI; HYDROGENATION; KINETICS | Calcium oxide; Carbon dioxide; Chemical shift; Hydrogenation; Methanation; Methane; Nickel compounds; Sorbents; Calcium looping; Dry reforming-of-methane; Green technology; Large scale source; Lower temperatures; Optimum temperature; Reverse water gas shift; Structural variations; carbon dioxide; carbon emission; methane; photolysis; Water gas shift | English | 2020 | 2020-11-01 | 10.1039/d0se00951b | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Interpreting the Subsurface Lithofacies at High Lithological Resolution by Integrating Information From Well-Log Data and Rock-Core Digital Images | Spectral facies interpretation and classification methods have been proposed to improve the sophistication of interpretation of the subsurface heterogeneity. In the spectral facies interpretations, the intensity values of the RGB spectrum and the local entropy from rock-core digital images are used, and the results are compared to conventional electrofacies and expert petrophysical interpretations. During the classification, a practically applicable model that identifies the more detailed types of lithofacies is constructed by using a multilayer neural network model, with the interpreted spectral facies and well-log data from the corresponding depths used as response and explanatory variables, respectively. Core digital images and five types of well-log data from the Satyr 5 well in Western Australia are applied for the actual implementation. Through comparative interpretations, three spectral facies are identified as separable lithofacies (i.e., shale, shaly-sandstone, and sandstone lithofacies), which is supported by detailed HyLogger mineralogy along the tested cores. On the other hand, two electrofacies (i.e., shale-dominant and sand-dominant facies) are identified by a conventional method. In the classification based on the spectral facies, the trained multilayer neural network model showed high prediction accuracy for all the lithofacies. Based on these observations, it is confirmed that more precise lithofacies interpretation and classification can be conducted with the developed methods. The developed methods have the potential to improve subsurface characterization when high lithological resolution is essential. | Jeong, Jina; Park, Eungyu; Emelyanova, Irina; Pervukhina, Marina; Esteban, Lionel; Yun, Seong-Taek | Kyungpook Natl Univ, Dept Geol, Daegu, South Korea; Commonwealth Sci & Ind Res Org CSIRO Energy, Perth, WA, Australia; Korea Univ, Earth & Environm Sci, Seoul, South Korea | Esteban, Lionel/E-8269-2013; Emelyanova, Irina/F-7743-2011 | 55488558800; 23995577700; 23501352100; 24339119300; 16039005100; 57221362072 | jeongj@knu.ac.kr;egpark@knu.ac.kr; | JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH | J GEOPHYS RES-SOL EA | 2169-9313 | 2169-9356 | 125 | 2 | SCIE | GEOCHEMISTRY & GEOPHYSICS | 2020 | 3.848 | 24.4 | 0.88 | 2025-06-25 | 14 | 16 | SMALL-SCALE HETEROGENEITY; ELECTROFACIES CHARACTERIZATION; PERMEABILITY PREDICTIONS; WIRELINE LOGS; LOGGING DATA; CLASSIFICATION; RESERVOIR; SEGMENTATION; POROSITY; EXAMPLE | Gaussian mixture model; lithofacies interpretation; multilayer neural network; rock-core digital images; spectral facies; well-log data | Australia; Western Australia; artificial neural network; data interpretation; digital image; Gaussian method; image classification; lithofacies; lithology; resolution; sediment core; well logging | English | 2020 | 2020-02 | 10.1029/2019jb018204 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Nanostructuring SnTe to improve thermoelectric properties through Zn and Sb co-doping | The suitability of tin telluride (SnTe) as a potential alternative thermoelectric material avidly continues and the outcome so far has been superbly promising. In our research, both Zn doped and Zn and Sb co-doped SnTe were studied. We show that introducing the ZnTe second phase plays a significantly crucial role in improving the thermoelectric properties of pristine SnTe. In addition, the Sb-rich layered structure has a paramount effect on specially reducing the phonon mean free path (PMFP) during dispersion. An anomalous behavior is observed in Zn doped SnTe, where slight doping results in increased electrical conductivity. On the other hand, Sb co-doping significantly reduces the carrier concentration and electrical conductivity is seen to decrease with increasing Sb concentration. A maximum Seebeck coefficient of similar to 170 mu V K-1 in a 15 mol% Sb co-doped sample emanates from the band convergence effect of Zn in SnTe and reduction of the carrier concentration; and an overall maximum power factor (PF) of similar to 17.2 mu W cm(-1) K-2 at 773 K is also reported. The astounding effect of Sb addition on modulation of the carrier concentration is evident in the ultra-low electronic thermal contribution (kappa(e)). An improved Vickers hardness value of up to 130 Hv and a two-fold improved ZT of Zn doped SnTe to a value of similar to 0.6 is promising but there still remains room for further improvement. | Kihoi, Samuel Kimani; Lee, Ho Seong | Kyungpook Natl Univ, Sch Mat Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea | ; Kihoi, Samuel Kimani/IUM-8515-2023 | 57208396874; 55706810400 | hs.lee@knu.ac.kr; | SUSTAINABLE ENERGY & FUELS | SUSTAIN ENERG FUELS | 2398-4902 | 4 | 11 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 6.367 | 24.4 | 1.15 | 2025-06-25 | 29 | 28 | ULTRALOW THERMAL-CONDUCTIVITY; P-TYPE SNTE; DOPED SNTE; BAND CONVERGENCE; PERFORMANCE; FIGURE; MERIT; POWER; BI; ENHANCEMENT | Antimony; Carrier concentration; Electric conductivity; II-VI semiconductors; IV-VI semiconductors; Thermoelectric equipment; Thermoelectricity; Vickers hardness; Zinc; Anomalous behavior; Electrical conductivity; Layered Structures; Maximum power factor; Phonon mean free path; Thermal contributions; Thermo-Electric materials; Thermoelectric properties; antimony; electrical power; nanomaterial; thermal power; zinc; Tin compounds | English | 2020 | 2020-11-01 | 10.1039/d0se01081b | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Solventless thermal crosslinked polymer protective layer for high stable lithium metal batteries | Owing to its high theoretical capacity (3860 mA h g(-1)), Li metal is emerging as a next-generation anode material. However, its volume expansion is a major obstacle in its commercialization because it causes the collapse of the solid electrolyte interphase layer and lowers the coulombic efficiency of the battery. Moreover, it induces dendrite formation, which causes internal short circuits. To overcome this obstacle, we propose the use of a cross-linked poly(ethylene glycol) dimethacrylate (c-PEGDMA) film containing ethylene oxide units as a protective layer for the metal surface. We prepared the c-PEGDMA by using a simple solventless process. It was coated on the surface of Li metal for a short time and thermally cured. The film was found to inhibit the volume expansion of Li metal during cycling, thereby reducing coulombic efficiency degradation and dendrite growth. The proposed surface stabilization technique is expected to be effective for Li metal batteries. | Kim, Hyunjin; Kim, Youn Sang; Yoo, Jeeyoung | Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Program Nano Sci & Technol, Seoul 151744, South Korea; Adv Inst Convergence Technol, 864-1 Iui Dong, Suwon 443270, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea | Kim, SoW/ABB-7917-2021; Yoo, Jeeyoung/AAH-1359-2019 | 59564809200; 8938854200; 56046607500 | jyoo@knu.ac.kr; | SUSTAINABLE ENERGY & FUELS | SUSTAIN ENERG FUELS | 2398-4902 | 4 | 2 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 6.367 | 24.4 | 0.22 | 2025-06-25 | 4 | 5 | GRAPHITE ELECTRODE; ION BATTERIES; CHALLENGES; ANODE; LIF | Anodes; Efficiency; Ethylene; Expansion; Lithium batteries; Polyethylene glycols; Solid electrolytes; Solid-State Batteries; Coulombic efficiency; Cross-linked polymers; Dendrite formation; Poly(ethylene glycol) dimethacrylate; Protective layers; Solid electrolyte interphase; Surface stabilization; Theoretical capacity; chemical bonding; commercialization; electrochemistry; electrolyte; energy efficiency; energy storage; ethylene; film; lithium; polymer; reduction; Lithium | English | 2020 | 2020-02-01 | 10.1039/c9se01046g | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Correction | Solventless thermal crosslinked polymer protective layer for high stable lithium metal batteries (vol 52, pg 686, 2020) | Correction for 'Solventless thermal crosslinked polymer protective layer for high stable lithium metal batteries' by Hyunjin Kim et al., Sustainable Energy Fuels, 2020, DOI: ; 10.1039/c9se01046g. | Kim, Hyunjin; Kim, Youn Sang; Yoo, Jeeyoung | Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Program Nano Sci & Technol, Seoul 151744, South Korea; Adv Inst Convergence Technol, 864-1 Iui Dong, Suwon 443270, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea | Yoo, Jeeyoung/AAH-1359-2019; Kim, SoW/ABB-7917-2021 | 59564809200; 8938854200; 56046607500 | SUSTAINABLE ENERGY & FUELS | SUSTAIN ENERG FUELS | 2398-4902 | 4 | 2 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 6.367 | 24.4 | 0 | 2025-06-25 | 0 | 0 | English | 2020 | 2020-02-01 | 10.1039/d0se90015j | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Transformation of a proton insulator to a conductor via reversible amorphous to crystalline structure transformation of MOFs | In this study, a successful proton conduction modulation of MOFs, from an ionic insulator to an ionic conductor, is demonstrated through their structural transformation. It is shown that the reversible structural change from amorphous to crystalline phases allows for the reversible proton conduction modulation of MOFs. Moreover, the proton conduction mechanism of the ionic conductor phase is elucidated by H-2 NMR analysis. | Song, Yoodae; Khudozhitkov, Alexander E.; Lee, Jihyun; Kang, Hyosik; Kolokolov, Daniil, I; Stepanov, Alexander G.; Yoon, Minyoung | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Gachon Univ, Dept Nanochem, Seongnam 13420, South Korea; Russian Acad Sci, Siberian Branch, Boreskov Inst Catalysis, Novosibirsk 630090, Russia; Novosibirsk State Univ, Novosibirsk 630090, Russia | Khudozhitkov, Alexandr/O-4812-2017; Stepanov, Alexander/AAB-8065-2022; Kolokolov, Daniil/I-4273-2012 | 57193251789; 57023987800; 57211144130; 57203503399; 24766214700; 7402418240; 25222186500 | kdi@catalysis.ru;myyoon@knu.ac.kr; | CHEMICAL COMMUNICATIONS | CHEM COMMUN | 1359-7345 | 1364-548X | 56 | 32 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2020 | 6.222 | 24.4 | 0.74 | 2025-06-25 | 10 | 11 | COORDINATION; MAGNESIUM | Ionic conduction; Ionic conductivity; metal organic framework; proton; Crystalline phasis; Crystalline structure; Ionic conductor; Ionic insulators; NMR analysis; Proton conduction; Proton conduction mechanisms; Structural transformation; adsorption; Article; chemical analysis; chemical procedures; chemical structure; conductance; crystallization; deuteron nuclear magnetic resonance; humidity; hydrogen bond; infrared spectroscopy; isotherm; protonation; structure analysis; synthesis; temperature; water vapor; X ray diffraction; Modulation | English | 2020 | 2020-04-25 | 10.1039/d0cc00755b | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Clinical outcomes of coronavirus disease 2019 in patients with pre-existing liver diseases: A multicenter study in South Korea | Background/Aims: Although coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, the implication of pre-existing liver disease on the outcome of COVID-19 remains unresolved. Methods: A total of 1,005 patients who were admitted to five tertiary hospitals in South Korea with laboratory-confirmed COVID-19 were included in this study. Clinical outcomes in COVID-19 patients with coexisting liver disease as well as the predictors of disease severity and mortality of COVID-19 were assessed. Results: Of the 47 patients (4.7%) who had liver-related comorbidities, 14 patients (1.4%) had liver cirrhosis. Liver cirrhosis was more common in COVID-19 patients with severe pneumonia than in those with non-severe pneumonia (4.5% vs. 0.9%, P=0.006). Compared to patients without liver cirrhosis, a higher proportion of patients with liver cirrhosis required oxygen therapy; were admitted to the intensive care unit; had septic shock, acute respiratory distress syndrome, or acute kidney injury; and died (P<0.05). The overall survival rate was significantly lower in patients with liver cirrhosis than in those without liver cirrhosis (log-rank test, P=0.003). Along with old age and diabetes, the presence of liver cirrhosis was found to be an independent predictor of severe disease (odds ratio, 4.52; 95% confidence interval [CI], 1.20-17.02; P=0.026) and death (hazard ratio, 2.86; 95% CI, 1.04-9.30; P=0.042) in COVID-19 patients. Conclusions: This study suggests liver cirrhosis is a significant risk factor for COVID-19. Stronger personal protection and more intensive treatment for COVID-19 are recommended in these patients. | Lee, Yu Rim; Kang, Min Kyu; Song, Jeong Eun; Kim, Hyun Jung; Kweon, Young Oh; Tak, Won Young; Jang, Se Young; Park, Jung Gil; Lee, Changhyeong; Hwang, Jae Seok; Jang, Byoung Kuk; Suh, Jeong Ill; Chung, Woo Jin; Kim, Byung Seok; Park, Soo Young | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Daegu Gyeongbuk Liver Study Grp, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Daegu, South Korea; Daegu Catholic Univ, Sch Med, Dept Internal Med, 33 Duryugongwon Ro 17 Gil, Daegu 42472, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, 1035 Dalgubeul Daero, Daegu 42601, South Korea; Dongguk Univ, Gyeongju Hosp, Coll Med, Dept Internal Med, Gyeongju, South Korea | Kang, Min/U-8050-2018; Kim, Seul Kee/A-6076-2015; Park, Jung/AAK-5167-2020; Kim, Jin Hyoung/AAE-8050-2019; song, jeong/P-9106-2015; Hyun-Jung, Kim/E-8074-2011 | 57194094753; 59142854300; 57189097150; 57196215317; 7004694832; 7004074582; 57202881977; 57216816399; 55784781600; 57205851488; 58849853600; 7201515001; 55741230500; 55974276800; 57191674344 | chung50@dsmc.or.kr;kbs9225@cu.ac.kr;psyoung0419@gmail.com; | CLINICAL AND MOLECULAR HEPATOLOGY | CLIN MOL HEPATOL | 2287-2728 | 2287-285X | 26 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 6.074 | 24.5 | 1.25 | 2025-06-25 | 22 | 24 | Liver diseases; Liver cirrhosis; Prognosis; Mortality; COVID-19 | CIRRHOSIS; INFECTIONS; MANAGEMENT; FAILURE; RISK | COVID-19; Liver cirrhosis; Liver diseases; Mortality; Prognosis | alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; bilirubin; C reactive protein; cobicistat plus darunavir; creatine kinase; creatinine; hydroxychloroquine; immunoglobulin; lactate dehydrogenase; lactic acid; lopinavir; potassium; procalcitonin; ritonavir; serum albumin; sodium; acute kidney failure; adult; adult respiratory distress syndrome; aged; Article; artificial ventilation; bacteremia; clinical outcome; computer assisted tomography; coronavirus disease 2019; death; disease severity; extracorporeal oxygenation; female; forced expiratory volume; hospitalization; human; intensive care unit; kidney function test; liver cirrhosis; liver disease; liver function test; liver transplantation; major clinical study; male; mortality; multicenter study; overall survival; oxygen therapy; pneumonia; risk factor; septic shock; Severe acute respiratory syndrome coronavirus 2; South Korea; survival rate; urea nitrogen blood level | English | 2020 | 2020-10 | 10.3350/cmh.2020.0126 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Entecavir plus tenofovir vs. lamivudine/telbivudine plus adefovir in chronic hepatitis B patients with prior suboptimal response | Background/Aims: Suboptimal responses to lamivudine or telbivudine plus adefovir (LAM/LdT+ADV) rescue therapy are common in patients with LAM-resistant hepatitis B virus (HBV) infections. We compared patients switched to entecavir plus tenofovir (ETV+TDF) to those maintained on LAM/LdT+ADV. Methods: This prospective randomized controlled trial examined 91 patients whose serum HBV DNA levels were greater than 60 IU/mL after at least 24 weeks of treatment with LAM/LdT+ADV for LAM-resistant HBV. Patients were randomized to receive a new treatment (ETV+TDF, n=45) or maintained on the same treatment (LAM/LdT+ADV, n=46) for 48 weeks. Patients with baseline ADV resistance were excluded. Results: Compared to LAM/LdT+ADV group, ETV+TDF group had more patients with a virologic response (42/45 [93.33%] vs. 3/46 [6.52%], P<0.001) and had a greater mean reduction in serum HBV DNA level from baseline (-4.16 vs. -0.37 log(10 )IU/mL, P<0.001). Multivariate analysis indicated that high baseline HBV DNA level (P=0.005) and LAM/LdT+ADV maintenance therapy (P=0.001) were negatively associated with virologic response. At week 48, additional ADV- or ETV-associated mutations were cleared in ETV+TDF group, but such mutations were present in 4.3% of patients in LAM/ LdT+ADV group (P=0.106). The two groups had similar rates of adverse events. Conclusions: ETV+TDF combination treatment led to a significantly higher rate of virologic response compared to LAM/ LdT+ADV combination treatment in patients with LAM-resistant HBV who had suboptimal responses to LAM/LdT+ADV regardless of HBV genotypic resistance profile (NCT01597934). | Woo, Hyun Young; Park, Jun Yong; Bae, Si Hyun; Kim, Chang Wook; Jang, Jae Young; Tak, Won Young; Kim, Dong Joon; Kim, In Hee; Heo, Jeong; Ahn, Sang Hoon | Pusan Natl Univ, Coll Med, Dept Internal Med, 179 Gudeok Ro, Busan 49241, South Korea; Pusan Natl Univ Hosp, Med Res Inst, 179 Gudeok Ro, Busan 49241, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Catholic Univ Korea, Dept Internal Med, Coll Med, Seoul, South Korea; Soonchunhyang Univ, Digest Dis Ctr, Inst Digest Res, Dept Internal Med,Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Hallym Univ, Coll Med, Dept Internal Med, Chunchon, South Korea; Hallym Univ, Inst Liver & Digest Dis, Chunchon, South Korea; Chonbuk Natl Univ, Chonbuk Natl Univ Hosp, Dept Internal Med, Coll Med, Chonju, South Korea | ; Kim, Chang/G-5001-2015; Park, Jun/H-7127-2019; Kim, Young/T-8521-2019; Heo, Jeong/MHQ-1390-2025; Ahn, Sang Hoon/AFM-2603-2022 | 12787138800; 47861376300; 57578310300; 57212853555; 57221679776; 7004074582; 55806065600; 7404143744; 8422238800; 7401989551 | jheo@pusan.ac.kr;ahnsh@yuhs.ac; | CLINICAL AND MOLECULAR HEPATOLOGY | CLIN MOL HEPATOL | 2287-2728 | 2287-285X | 26 | 3 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 6.074 | 24.5 | 0.16 | 2025-06-25 | 9 | 8 | Entecavir; Tenofovir; Lamivudine; Antiviral drug resistance; Adefovir | TERM LAMIVUDINE THERAPY; RESCUE THERAPY; HEPATOCELLULAR-CARCINOMA; VIROLOGICAL RESPONSE; NAIVE PATIENTS; RESISTANT; COMBINATION; EFFICACY; DIPIVOXIL; RISK | Adefovir; Antiviral drug resistance; Entecavir; Lamivudine; Tenofovir | adefovir; alanine aminotransferase; aspartate aminotransferase; entecavir; hepatitis B(e) antigen; lamivudine; peginterferon alpha2a; telbivudine; tenofovir; virus DNA; adult; Article; blood sampling; chronic hepatitis B; clinical effectiveness; controlled study; disease association; dyspepsia; female; follow up; gene mutation; genetic resistance; Hepatitis B virus; human; liver cirrhosis; major clinical study; male; multicenter study; nausea; nonhuman; prospective study; randomized controlled trial; reverse transcription polymerase chain reaction; thorax pain; treatment duration; treatment response; virus load | English | 2020 | 2020-07 | 10.3350/cmh.2019.0044n | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Inhibition of PTP1B by farnesylated 2-arylbenzofurans isolated from Morus alba root bark: unraveling the mechanism of inhibition based on in vitro and in silico studies | Among the 2-arylbenzofuran derivatives isolated fromMorus alba, the farnesylated 2-arylbenzofuran is a rarer constituent. The derivative has been reported to exert anti-obesity effect; however, its inhibitory effect on protein tyrosine phosphatase 1B (PTP1B) has not been investigated. In the previous study, the presence of the farnesyl group in the structure of 2-arylbenzofurans was found to have positive influences on their pancreatic lipase inhibitory activity. In the present study, we have confirmed the authenticity of the notation based on the PTP1B inhibitory activity of farnesylated 2-arylbenzofurans. Specifically, two farnesylated 2-arylbenzofurans [morusalfurans B (2) and C (3)] showed strong inhibitory effects on PTP1B with IC(50)values of 8.92 and 7.26 mu M, respectively, which was significantly higher than that of the positive controls [sodium orthovanadate (IC50 = 15.10 mu M) and ursolic acid (IC50 = 11.34 mu M)]. Besides, two 2-arylbenzofurans [morusalfurans A (1) and F (6)], one flavonoid [morusalnol B (9)], and one geranylated stilbene [morusibene A (11)] exhibited PTP1B inhibition with IC(50)values ranging from 11.02 to 26.56 mu M. Kinetic studies revealed compounds2,3,6, and11as mixed type PTP1B inhibitors, while1and9are known as noncompetitive. Molecular docking simulations demonstrated that these active compounds can bind with the respective catalytic or/and allosteric sites of PTP1B with negative binding energies and the results are in accordance with that of the kinetic studies. To the best of our knowledge, this is the first time, the PTP1B inhibitory activity of eleven compounds (1-11), as well as the mechanism of action underlying the effects on PTP1B enzyme of the active compounds, were investigated. In vitro and in silico results suggest that the farnesylated 2-arylbenzofurans fromM. albamay potentially be utilized as an effective treatment therapy for type 2 diabetes mellitus and its associated complications. | Ha, Manh Tuan; Shrestha, Srijan; Tran, Thu Huong; Kim, Jeong Ah; Woo, Mi Hee; Choi, Jae Sue; Min, Byung Sun | Daegu Catholic Univ, Coll Pharm, Drug Res & Dev Ctr, Gyeongbuk 38430, South Korea; Hanoi Univ Sci & Technol, Sch Chem Engn, Hanoi, Vietnam; Pukyong Natl Univ, Dept Food & Life Sci, Busan 48513, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 702701, South Korea; Univ Adelaide, Sch Med, Discipline Pharmacol, Fac Hlth Sci, Adelaide, SA, Australia | Tuan, Ha/AAW-5444-2021; Tran, Thu Huong/LIC-4838-2024 | 57189040434; 9132885700; 57037751000; 24722570900; 7201527720; 25654629500; 55663638200 | choijs@pknu.ac.kr;bsmin@cu.ac.kr; | ARCHIVES OF PHARMACAL RESEARCH | ARCH PHARM RES | 0253-6269 | 1976-3786 | 43 | 9 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2020 | 4.946 | 24.5 | 1.36 | 2025-06-25 | 20 | 22 | Morus alba; Moraceae; Farnesylated 2-arylbenzofurans; Protein tyrosine phosphatase 1B; Kinetic; Molecular docking | INSULIN SENSITIVITY; DIABETES-MELLITUS; PROTEIN; L.; CHOLINESTERASE; BIOACTIVITIES; CONSTITUENTS; ANTIOXIDANT; DERIVATIVES; MULBERRY | Farnesylated 2-arylbenzofurans; Kinetic; Molecular docking; Moraceae; Morus alba; Protein tyrosine phosphatase 1B | Allosteric Regulation; Benzofurans; Catalytic Domain; Diabetes Mellitus, Type 2; Enzyme Assays; Humans; Hypoglycemic Agents; Inhibitory Concentration 50; Insulin; Kinetics; Molecular Docking Simulation; Morus; Plant Bark; Plant Extracts; Plant Roots; Prenylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; morusalfuran A; morusalfuran B; morusalfuran C; morusalfuran D; morusalfuran E; morusalfuran F; morusalfuran G; morusalnol A; morusalnol B; morusalnol C; morusibene A; protein tyrosine phosphatase 1B inhibitor; unclassified drug; ursolic acid; vanadate sodium; antidiabetic agent; benzofuran derivative; insulin; plant extract; protein tyrosine phosphatase 1B; PTPN1 protein, human; allosterism; Article; bark; computer model; controlled study; drug determination; drug isolation; drug mechanism; drug structure; enzyme activity; enzyme inhibition; farnesylation; IC50; in vitro study; molecular docking; Morus alba; nonhuman; plant root; bark; chemistry; drug effect; enzyme active site; enzyme assay; human; isolation and purification; kinetics; metabolism; Morus; non insulin dependent diabetes mellitus; plant root; prenylation | English | 2020 | 2020-09 | 10.1007/s12272-020-01269-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Lactobacillus attenuates progression of nonalcoholic fatty liver disease by lowering cholesterol and steato-sis | Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is closely related to gut-microbiome. There is a paucity of research on which strains of gut microbiota affect the progression of NAFLD. This study explored the NAFLD-associated microbiome in humans and the role of Lactobacillus in the progression of NAFLD in mice. Methods: The gut microbiome was analyzed via next-generation sequencing in healthy people (n=37) and NAFLD patients with elevated liver enzymes (n=57). Six-week-old male C57BL/6J mice were separated into six groups (n=10 per group; normal, Western, and four Western diet + strains [109 colony-forming units/g for 8 weeks; L. acidophilus, L. fermentum, L. paracasei, and L. plantarum]). Liver/body weight ratio, liver pathology, serum analysis, and metagenomics in the mice were examined. Results: Compared to healthy subjects (1.6±4.3), NAFLD patients showed an elevated Firmicutes/Bacteroidetes ratio (25.0±29.0) and a reduced composition of Akkermansia and L. murinus (P<0.05). In the animal experiment, L. acidophilus group was associated with a significant reduction in liver/body weight ratio (5.5±0.4) compared to the Western group (6.2±0.6) (P<0.05). L. acidophilus (41.0±8.6), L. fermentum (44.3±12.6), and L. plantarum (39.0±7.6) groups showed decreased cholesterol levels compared to the Western group (85.7±8.6) (P<0.05). In comparison of steatosis, L. acidophilus (1.9±0.6), L. plantarum (2.4±0.7), and L. paracasei (2.0±0.9) groups showed significant improvement of steatosis compared to the Western group (2.6±0.5) (P<0.05). Conclusions: Ingestion of Lactobacillus, such as L. acidophilus, L. fermentum, and L. plantarum, ameliorates the progression of nonalcoholic steatosis by lowering cholesterol. The use of Lactobacillus can be considered as a useful strategy for the treatment of NAFLD. © 2021 by Korean Association for the Study of the Liver. | Lee, Na Young; Shin, Min Jea; Youn, Gi Soo; Yoon, Sang Jun; Choi, Ye Rin; Kim, Hyeong Seop; Gupta, Haripriya; Han, Sang Hak; Kim, Byoung Kook; Lee, Do Yup; Park, Tae Sik; Sung, Hotaik; Kim, Byung Yong; Suk, Ki Tae | 1nstitue for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, South Korea; 1nstitue for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, South Korea; 1nstitue for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, South Korea; 1nstitue for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, South Korea; 1nstitue for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, South Korea; 1nstitue for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, South Korea; 1nstitue for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, South Korea; Department of Pathology, Hallym University College of Medicine, Chuncheon, South Korea; Chong Kun Dang Bio Research Institute, Ansan, South Korea; Department of Agricultural Biotechnol-ogy, Seoul National University, Seoul, South Korea; Department of Life Science, Gachon University, Sungnam, South Korea; Department of Medicine, College of Medicine, Kyungpook National University, Daegu, South Korea; Department of Microbiome, ChunLab, Inc, Seoul, South Korea; 1nstitue for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon, South Korea | 57214223390; 35485651200; 54894334000; 57214226795; 57220602316; 57221500943; 57211533706; 57207284742; 57214083378; 37047058900; 13611391800; 55240452500; 7501565352; 57226393680 | bykim@chunlab.com;ktsuk@hallym.ac.kr; | Clinical and Molecular Hepatology | CLIN MOL HEPATOL | 2287-2728 | 2287-285X | 27 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 6.074 | 24.5 | 2.89 | 2025-06-25 | 102 | Cholesterol; Gut microbiome; Lactobacillus; Nonalcoholic fatty liver disease; Probiotics | alanine aminotransferase; aspartate aminotransferase; cholesterol; creatine; eosin; formaldehyde; gamma glutamyltransferase; hematoxylin; high density lipoprotein cholesterol; interleukin 1beta; interleukin 6; isoflurane; paraffin; RNA 16S; triacylglycerol; trizol; tumor necrosis factor; Actinobacteria; adult; Aerococcaceae; Akkermansia; animal experiment; animal model; Article; Bacteroidetes; blood cell count; body mass; body weight; cholesterol blood level; cholesterol metabolism; colony forming unit; computer assisted tomography; controlled study; disease exacerbation; DNA extraction; DNA sequencing; drug overdose; echography; Enterococcaceae; fatty liver; feces analysis; female; fermentation; Firmicutes; gene expression; glucose blood level; Granulicatella; high throughput sequencing; human; inflammation; intestine flora; Lactobacillus; Lactobacillus acidophilus; Lactobacillus fermentum; Lactobacillus paracasei; Lactobacillus plantarum; Lactococcus; Leuconostocaceae; lipid metabolism; liver function test; liver weight; major clinical study; male; metagenomics; microbial community; microbial identification; middle aged; mouse; mRNA expression level; nonalcoholic fatty liver; nonhuman; observational study; polymerase chain reaction; prospective study; protein expression; Proteobacteria; Streptococcaceae; Streptococcus; Western diet | English | Final | 2020 | 10.3350/cmh.2020.0125 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Pharmacokinetics of ginsenosides following repeated oral administration of red ginseng extract significantly differ between species of experimental animals | We aimed to investigate ginsenoside pharmacokinetics in mice and rats following the repeated oral administration of red ginseng extract (RGE) (2 g/kg/day for 7 days). In mouse plasma, seven protopanaxadiol (PPD)-type ginsenosides (20(S)-ginsenoside Rb1, Rb2, Rc, Rd, Rg3, 20(S)-compound K, and 20(S)-PPD) and one protopanaxatriol (PPT)-type 20(S)-ginsenoside Re were detected, whereas 20(S)-ginsenoside Rb1, Rb2, Rc, Rd, 20(S)-PPD, and 20(S)-PPT were detected in rat plasma. The tetra- or tri-glycosylated PPD-type ginsenosides Rb1, Rb2, Rc, and Rd, high content ginsenosides in RGE, showed high plasma exposure, a short absorption time (T-max), and a long elimination time (T-1/2) among the ginsenosides detected in both species. Among the deglycosylated metabolites existing in the feces, 20(S)-compound K and 20(S)-PPD in mice and 20(S)-PPD and 20(S)-PPT in rats were found in the plasma samples. In addition to the differences in the ginsenosides detected in mice and rats, the T-max and T-1/2 of 20(S)-PPD and 20(S)-PPT in rats were greater than those in mice, suggesting the species-dependent difference in the gut metabolism and absorption of ginsenosides in the pathway from 20(S)-ginsenoside Rd to 20(S)-PPD and from 20(S)-ginsenoside Re to 20(S)-PPT. In conclusion, the choice of animal model should be the subject of careful consideration when exploring the pharmacology of RGE with specific focus on the plasma profile of an individual ginsenoside. | Jeon, Ji-Hyeon; Lee, Jaehyeok; Choi, Min-Koo; Song, Im-Sook | Kyungpook Natl Univ, Coll Pharm, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, 80 Daehakro, Daegu 41566, South Korea; Dankook Univ, Coll Pharm, Cheonan 31116, South Korea | 57204685946; 57219980183; 8695781400; 7201564500 | isssong@knu.ac.kr; | ARCHIVES OF PHARMACAL RESEARCH | ARCH PHARM RES | 0253-6269 | 1976-3786 | 43 | 12 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2020 | 4.946 | 24.5 | 2.17 | 2025-06-25 | 39 | 38 | Pharmacokinetics; Ginsenosides; Red ginseng extract; Gut metabolism; Absorption | METABOLITE COMPOUND K; PANAX-GINSENG; BIOAVAILABILITY; NOTOGINSENG; RB1 | Absorption; Ginsenosides; Gut metabolism; Pharmacokinetics; Red ginseng extract | Administration, Oral; Animals; Drug Administration Schedule; Gastrointestinal Absorption; Ginsenosides; Glycosylation; Half-Life; Male; Mice, Inbred ICR; Panax; Plant Extracts; Rats, Sprague-Dawley; Species Specificity; ginseng extract; ginsenoside; ginsenoside; plant extract; animal experiment; Article; controlled study; drug elimination; drug structure; ginseng; human; male; mean absorption time; mouse; nonhuman; rat; animal; blood; chemistry; comparative study; drug administration; gastrointestinal absorption; glycosylation; half life time; Institute for Cancer Research mouse; isolation and purification; oral drug administration; Panax; species difference; Sprague Dawley rat | English | 2020 | 2020-12 | 10.1007/s12272-020-01289-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Phytochemical and pharmacological properties of Myristica fragrans Houtt.: an updated review | Myristica fragrans Houtt. (Myristicaceae), an aromatic evergreen tree, is well known as a commercial source of mace (aril) and nutmeg (seed), which have long been widely used as spices in the culinary field. In addition, various parts of M. fragrans have been used in folk medicine for treating several diseases. Since its extensive uses in the culinary sector and folk medicine, M. fragrans has long attracted a great deal of attention from pharmacologists and chemists. Numerous studies have indicated that M. fragrans contains diverse phytochemicals such as lignans, neolignans, diphenylalkanes, phenylpropanoids, and terpenoids, which exhibit many of pharmacological activities. Among them, macelignan (1), meso-dihydroguaiaretic acid (2), myristicin (111), and malabaricone C (Mal C, 104) are the most active compounds. The aim of this review is to comprehensively summarize the phytochemical and pharmacological properties of M. fragrans that have reported to date. | Ha, Manh Tuan; Vu, Ngoc Khanh; Tran, Thu Huong; Kim, Jeong Ah; Woo, Mi Hee; Min, Byung Sun | Daegu Catholic Univ, Coll Pharm, Drug Res & Dev Ctr, Gyeongbuk 38430, South Korea; Hanoi Univ Sci & Technol, Sch Chem Engn, Hanoi, Vietnam; Kyungpook Natl Univ, Coll Pharm, Daegu 702701, South Korea | ; Tran, Thu Huong/LIC-4838-2024; Tuan, Ha/AAW-5444-2021; khanh, vu/JXL-3187-2024 | 57189040434; 57217172502; 57037751000; 24722570900; 7201527720; 55663638200 | bsmin@cu.ac.kr; | ARCHIVES OF PHARMACAL RESEARCH | ARCH PHARM RES | 0253-6269 | 1976-3786 | 43 | 11 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2020 | 4.946 | 24.5 | 1.43 | 2025-06-25 | 72 | 87 | Myristica fragrans; Myristicaceae; Lignan; Neolignan; Diphenylalkane; Malabaricone C | DIMERIC PHENYLPROPANOIDS; CHEMICAL-CONSTITUENTS; METABOLIZING-ENZYMES; ANTIFUNGAL ACTIVITY; ESSENTIAL OIL; NO PRODUCTION; NUTMEG OIL; LIGNANS; MACE; ANTIOXIDANT | Diphenylalkane; Lignan; Malabaricone C; Myristica fragrans; Myristicaceae; Neolignan | Analgesics; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Humans; Molecular Structure; Myristica; Phytochemicals; Plant Extracts; Structure-Activity Relationship; 2 akylcyclobutanone derivative; alkane derivative; cyclobutanone derivative; diphenylalkane; fatty acid; fatty acid ester; flavonoid; herbaceous agent; lignan; macelignan; malabaricone C; meso dihydroguaiaretic acid; Myristica fragrans extract; myristicin; neolignan; phenylpropanoid; phytochemical; phytosterol; plant extract; saponin; terpene; terpene derivative; terpenoid; triterpenoid; unclassified drug; analgesic agent; antiinfective agent; antiinflammatory agent; antineoplastic agent; antioxidant; phytochemical; plant extract; analgesic activity; antibacterial activity; antidiabetic activity; antifungal activity; antiinflammatory activity; antineoplastic activity; antiobesity activity; antioxidant activity; chemoprophylaxis; drug structure; heart protection; human; liver protection; neuropharmacology; nonhuman; nutmeg; pharmacological parameters; phytochemistry; Review; toxicological parameters; animal; chemical structure; chemistry; isolation and purification; Myristica; structure activity relation; toxicity | English | 2020 | 2020-11 | 10.1007/s12272-020-01285-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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