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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Restoration of Cathepsin D Level via L-Serine Attenuates PPA-Induced Lysosomal Dysfunction in Neuronal Cells | L-serine is a non-essential amino acid endogenously produced by astrocytes and is abundant in human diets. Beneficial roles of the metabolic products from L-serine in various conditions in the brain including neuronal development have been reported. Through several preclinical studies, L-serine treatment was also shown to offer beneficial therapeutic effects for brain damage such as ischemic stroke, amyotrophic lateral sclerosis, and Parkinson's disease. Despite evidence for the value of L-serine in the clinic, however, its beneficial effects on the propionic acid (PPA)-induced neuronal toxicity and underlying mechanisms of L-serine-mediated neuroprotection are unknown. In this study, we observed that PPA-induced acidic stress induces abnormal lipid accumulation and functional defects in lysosomes of hippocampal neurons. L-serine treatment was able to rescue the structure and function of lysosomes in PPA-treated hippocampal neuronal cells. We further identified that L-serine suppressed the formation of lipid droplets and abnormal lipid membrane accumulations inside the lysosomes in PPA-treated hippocampal neuronal cells. Taken together, these findings indicate that L-serine can be utilized as a neuroprotective agent for the functionality of lysosomes through restoration of cathepsin D in disease conditions. | Jeon, Hyunbum; Kim, Yeo Jin; Hwang, Su-Kyeong; Seo, Jinsoo; Mun, Ji Young | Korea Brain Res Inst, Neural Circuit Res Grp, Daegu 41062, South Korea; Daegu Gyeongbuk Inst Sci & Technol DGIST, Dept Brain Sci, Daegu 42988, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu 41944, South Korea; Astrogen Inc, 440 Hyeoksin Daero, Daegu 41072, South Korea | ; Mun, Jiyoung/IUN-3520-2023; Seo, Jinsoo/AAD-4950-2019 | 57558931700; 57225107404; 37761570400; 7401783716; 8654053900 | jymun@kbri.re.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 18 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 0.53 | 2025-06-25 | 5 | 6 | L-serine; lysosome; lipid droplet; propionic acid (PPA); neuron | CHAIN FATTY-ACIDS; TRIACYLGLYCEROL ACCUMULATION; AMINO-ACID; EXPRESSION | L-serine; lipid droplet; lysosome; neuron; propionic acid (PPA) | Cathepsin D; Humans; Lysosomes; Neurons; Neuroprotective Agents; Propionates; Serine; cathepsin D; fat droplet; neuroprotective agent; propionic acid; serine; cathepsin D; neuroprotective agent; propionic acid derivative; serine; animal cell; Article; cell function; cell organelle; cell stress; cell structure; cell vacuole; cell viability; cellular distribution; controlled study; gene expression; hippocampus; HT22 cell line; lipid membrane; lipid storage; lysosome; nerve cell; neuroprotection; neurotoxicity; nonhuman; physiological stress; rat; human; metabolism; nerve cell | English | 2022 | 2022-09 | 10.3390/ijms231810613 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Review of the Current State of Freely Accessible Web Tools for the Analysis of 16S rRNA Sequencing of the Gut Microbiome | Owing to the emergence and improvement of high-throughput technology and the associated reduction in costs, next-generation sequencing (NGS) technology has made large-scale sampling and sequencing possible. With the large volume of data produced, the processing and downstream analysis of data are important for ensuring meaningful results and interpretation. Problems in data analysis may be encountered if researchers have little experience in using programming languages, especially if they are clinicians and beginners in the field. A strategy for solving this problem involves ensuring easy access to commercial software and tools. Here, we observed the current status of free web-based tools for microbiome analysis that can help users analyze and handle microbiome data effortlessly. We limited our search to freely available web-based tools and identified MicrobiomeAnalyst, Mian, gcMeta, VAMPS, and Microbiome Toolbox. We also highlighted the various analyses that each web tool offers, how users can analyze their data using each web tool, and noted some of their limitations. From the abovementioned list, gcMeta, VAMPS, and Microbiome Toolbox had several issues that made the analysis more difficult. Over time, as more data are generated and accessed, more users will analyze microbiome data. Thus, the availability of free and easily accessible web tools can enable the easy use and analysis of microbiome data, especially for those users with less experience in using command-line interfaces. | Ibal, Jerald Conrad; Park, Yeong-Jun; Park, Min-Kyu; Lee, Jooeun; Kim, Min-Chul; Shin, Jae-Ho | Kyungpook Natl Univ, NGS Core Facil, Daehak Ro 80, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daehak Ro 80, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biotechnol, Daehak Ro 80, Daegu 41566, South Korea | ; Ibal, Jerald/JYQ-0493-2024 | 57196117664; 56275800900; 7404490480; 57897128100; 57203466596; 57224125922 | jhshin@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 18 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 0.07 | 2025-06-25 | 3 | 2 | 16S rRNA; gut microbiome; next-generation sequencing; microbiome analysis; web-based tool | 16S rRNA; gut microbiome; microbiome analysis; next-generation sequencing; web-based tool | Gastrointestinal Microbiome; High-Throughput Nucleotide Sequencing; Microbiota; RNA, Ribosomal, 16S; Software; RNA 16S; RNA 16S; comparative study; data analysis; data processing; gastrointestinal tract; global catalogue of metagenomics; high throughput sequencing; high throughput technology; human; information processing; internet access; intestine flora; machine learning; metagenomics; microbial community; microbiome; nonhuman; population structure; Review; RNA analysis; RNA sequencing; visualization and analysis of microbial population structure; genetics; high throughput sequencing; microflora; procedures; software | English | 2022 | 2022-09 | 10.3390/ijms231810865 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Silk/Rayon Webs and Nonwoven Fabrics: Fabrication, Structural Characteristics, and Properties | Silk is a naturally occurring material and has been widely used in biomedical and cosmetic applications owing to its unique properties, including blood compatibility, excellent cytocompatibility, and a low inflammatory response in the body. A natural silk nonwoven fabric with good mechanical properties was recently developed using the binding property of sericin. In this study, silk/rayon composite nonwoven fabrics were developed to increase productivity and decrease production costs, and the effect of the silk/rayon composition on the structure and properties of the fabric was examined. The crystalline structure of silk and rayon was maintained in the fabric. As the silk content increased, the porosity and moisture regain of the silk/rayon web and nonwoven fabric decreased. As the silk content increased, the maximum stress of the web and nonwoven fabric increased, and the elongation decreased. Furthermore, the silk/rayon web exhibited the highest values of maximum stress and elongation at similar to 200 degrees C. Regardless of the silk/rayon composition, all silk/rayon nonwoven fabrics showed good cytocompatibility. Thus, the silk/rayon fabric is a promising material for cosmetic and biomedical applications owing to its diverse properties and high cell viability. | Bae, Yu Jeong; Jang, Mi Jin; Um, In Chul | Kyungpook Natl Univ, Dept Biofibers & Biomat Sci, Daegu 41566, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Preclin Res Ctr, Daegu 41061, South Korea | 57782228700; 57222997201; 7006725707 | qodbwjc109@knu.ac.kr;mijin22@kmedihub.re.kr;icum@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 14 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 1.06 | 2025-06-25 | 12 | 12 | silk; rayon; nonwoven fabric; mechanical properties; cytocompatibility | SILK FIBROIN; MOLECULAR-WEIGHT; MECHANICAL-PROPERTIES; IN-VITRO; SERICIN; REGENERATION; DISSOLUTION; SCAFFOLDS; CRYSTALLINITY; CELLULOSE | cytocompatibility; mechanical properties; nonwoven fabric; rayon; silk | Cellulose; Sericins; Silk; Textiles; cosmetic; polymer; rayon; sericin; silk; unclassified drug; cellulose; rayon, purified; sericin; animal cell; Article; biocompatibility; biomedicine; cell viability; controlled study; crystal structure; cytotoxicity; field emission scanning electron microscopy; moisture; mouse; nonhuman; porosity; productivity; structure analysis; temperature; X ray diffraction; chemistry; textile | English | 2022 | 2022-07 | 10.3390/ijms23147511 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | SUMOylation and Major Depressive Disorder | Since the discovery of the small ubiquitin-like modifier (SUMO) protein in 1995, SUMOylation has been considered a crucial post-translational modification in diverse cellular functions. In neurons, SUMOylation has various roles ranging from managing synaptic transmitter release to maintaining mitochondrial integrity and determining neuronal health. It has been discovered that neuronal dysfunction is a key factor in the development of major depressive disorder (MDD). PubMed and Google Scholar databases were searched with keywords such as 'SUMO', 'neuronal plasticity', and 'depression' to obtain relevant scientific literature. Here, we provide an overview of recent studies demonstrating the role of SUMOylation in maintaining neuronal function in participants suffering from MDD. | Jeoung, Seok-Won; Park, Hyun-Sun; Ryoo, Zae Young; Cho, Dong-Hyung; Lee, Hyun-Shik; Ryu, Hong-Yeoul | Kyungpook Natl Univ, Coll Natl Sci, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41566, South Korea; Inje Univ, Dept Biochem, Coll Med, Busan 50834, South Korea | ; Park, Hyeonsun/GSN-5362-2022; RYOO, ZAEYOUNG/AAQ-1573-2020; Choi, Hye Rin/JDV-9065-2023 | 57822770000; 57189620033; 16937104900; 35093684400; 16316010200; 55889917800 | swjeoung96@gmail.com;hspark@inje.ac.kr;jaewoong64@knu.ac.kr;dhcho@knu.ac.kr;leeh@knu.ac.kr;rhr4757@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 14 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 0.2 | 2025-06-25 | 6 | 6 | SUMOylation; major depressive disorder (MDD); neuron; synapse; mitochondria | LONG-TERM POTENTIATION; MITOCHONDRIAL FISSION; PROTEIN SUMOYLATION; HISTONE SUMOYLATION; SYNAPTIC PLASTICITY; SEROTONERGIC SYSTEM; PREFRONTAL CORTEX; SUMO MODIFICATION; CALCIUM INFLUX; MESSENGER-RNA | major depressive disorder (MDD); mitochondria; neuron; SUMOylation; synapse | Depressive Disorder, Major; Humans; Neurons; Protein Processing, Post-Translational; Small Ubiquitin-Related Modifier Proteins; Sumoylation; AMPA receptor; brain derived neurotrophic factor; cytoplasmic polyadenylation element binding protein; dopamine transporter; G protein coupled receptor; ion channel; mitogen activated protein kinase; mitogen activated protein kinase kinase; neuronal nitric oxide synthase; nitrous oxide; Raf protein; Ras protein; serotonin receptor; SNARE protein; ubiquitin; SUMO protein; disorders of mitochondrial functions; human; major depression; nerve cell plasticity; neurotransmitter release; pathogenesis; regulatory mechanism; Review; sumoylation; major depression; metabolism; nerve cell; protein processing | English | 2022 | 2022-07 | 10.3390/ijms23148023 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Plastome Sequences of Triticum sphaerococcum (ABD) and Triticum turgidum subsp. durum (AB) Exhibit Evolutionary Changes, Structural Characterization, Comparative Analysis, Phylogenomics and Time Divergence | The mechanism and course of Triticum plastome evolution is currently unknown; thus, it remains unclear how Triticum plastomes evolved during recent polyploidization. Here, we report the complete plastomes of two polyploid wheat species, Triticum sphaerococcum (AABBDD) and Triticum turgidum subsp. durum (AABB), and compare them with 19 available and complete Triticum plastomes to create the first map of genomic structural variation. Both T. sphaerococcum and T. turgidum subsp. durum plastomes were found to have a quadripartite structure, with plastome lengths of 134,531 bp and 134,015 bp, respectively. Furthermore, diploid (AA), tetraploid (AB, AG) and hexaploid (ABD, AGA(m)) Triticum species plastomes displayed a conserved gene content and commonly harbored an identical set of annotated unique genes. Overall, there was a positive correlation between the number of repeats and plastome size. In all plastomes, the number of tandem repeats was higher than the number of palindromic and forward repeats. We constructed a Triticum phylogeny based on the complete plastomes and 42 shared genes from 71 plastomes. We estimated the divergence of Hordeum vulgare from wheat around 11.04-11.9 million years ago (mya) using a well-resolved plastome tree. Similarly, Sitopsis species diverged 2.8-2.9 mya before Triticum urartu (AA) and Triticum monococcum (AA). Aegilops speltoides was shown to be the maternal donor of polyploid wheat genomes and diverged ~0.2-0.9 mya. The phylogeny and divergence time estimates presented here can act as a reference framework for future studies of Triticum evolution. | Lubna, Sajjad; Asaf, Sajjad; Jan, Rahmatullah; Khan, Abdul Latif; Ahmad, Waqar; Asif, Saleem; Al-Harrasi, Ahmed; Kim, Kyung-Min; Lee, In-Jung | Abdul Wali Khan Univ, Dept Bot, Garden Campus, Mardan 23200, Pakistan; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Div Plant Biosci, Daegu 41566, South Korea; Univ Houston, Coll Technol, Dept Engn Technol, Sugar Land, TX 77479 USA | Ul-Hamid, Anwar/B-7297-2015; Khan, Abdul/H-5910-2011; Jan, Rahmatullah/AIC-3439-2022; Asaf, Sajjad/ABA-3647-2021; Lee, In-Jung/GLS-0432-2022; Kim, Kyung-Min Kim/C-7007-2014; Ahmad, Waqar/ABC-8062-2021 | 57200621537; 56595059900; 57201981969; 26639372800; 59054664000; 57396413700; 6506093146; 34868260300; 16425830900 | lubnabilal68@gmail.com;sajadasif2000@gmail.com;rehmatbot@yahoo.com;latifepm78@yahoo.co.uk;waqarahmed111@gmail.com;saleemasif10@gmail.com;aharrasi@unizwa.edu.om;kkim@knu.ac.kr;ijlee@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 0.44 | 2025-06-25 | 5 | 5 | wheat; polyploidy; chloroplast genome; inverted repeats; Triticum sphaerococcum; Triticum turgidum subsp; durum | COMPLETE CHLOROPLAST GENOME; ACETYL-COA CARBOXYLASE; PHYLOGENETIC-RELATIONSHIPS; INVERTED REPEAT; GENUS TRITICUM; B-GENOME; WHEAT; POACEAE; AEGILOPS; DNA | Chloroplast genome; Inverted repeats; Polyploidy; Triticum sphaerococcum; Triticum turgidum subsp. durum; Wheat | Aegilops; Diploidy; Genome, Plant; Phylogeny; Polyploidy; Triticum; cytochrome b; cytochrome f; DNA directed RNA polymerase; initiation factor 2; membrane protein; palindromic DNA; proteinase; proton transporting adenosine triphosphate synthase; reduced nicotinamide adenine dinucleotide dehydrogenase; ribosome protein; ribosome RNA; ribulosebisphosphate carboxylase; transfer RNA; accD gene; Aegilops; Aegilops speltoides; angiosperm; Article; atpF gene; barley; Bayes theorem; ccsA gene; chloroplast genome; controlled study; cultivar; cytochrome synthesis gene; diploidy; DNA extraction; DNA structure; evolutionary adaptation; functional repeat; gene; gene content; gene dosage; gene loss; gene rearrangement; gene replication; gene sequence; genetic variability; genetic variation; genome size; geological time; hexaploidy; intron; large ribosomal subunit; large single copy region; matK gene; maximum likelihood method; model; molecular genetic phenomena and functions; molecular genetics; molecular phylogeny; ndhH gene; ndhJ gene; nonhuman; nucleotide sequence; open reading frame; petA gene; petL gene; photosynthesis; photosystem I; photosystem II; phylogenetic tree; phylogenomics; phylogeny; plant genetics; plastid genome; polyploidy; population structure; protein assembly; protein coding gene; psbD gene; psbE gene; psbl gene; rpl14 gene; rps12 gene; simple sequence repeat; small ribosomal subunit; small single copy region; structure analysis; substitution model; tandem repeat; tetraploidy; Triticum aestivum; Triticum durum; Triticum macha; Triticum monococcum; Triticum sphaerococcum; Triticum timopheevii; Triticum turgidum; trnL gene; wheat; wild barley; ycf1 gene; ycf15 gene; ycf2 gene; ycf3 gene; ycf68 gene; genetics; plant genome | English | 2022 | 2022-03 | 10.3390/ijms23052783 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Role of Exogenous Gibberellic Acid and Methyl Jasmonate against White-Backed Planthopper (Sogatella furcifera) Stress in Rice (Oryza sativa L.) | Rice (Oryza sativa L.) is one of the essential staple foods for more than half of the world's population, and its production is affected by different environmental abiotic and biotic stress conditions. The white-backed planthopper (WBPH, Sogatella furcifera) causes significant damage to rice plants, leading to substantial economic losses due to reduced production. In this experiment, we applied exogenous hormones (gibberellic acid and methyl jasmonate) to WBPH-infested rice plants and examined the relative expression of related genes, antioxidant accumulation, the recovery rate of affected plants, endogenous hormones, the accumulation of H2O2, and the rate of cell death using DAB and trypan staining, respectively. The expression of the transcriptional regulator (OsGAI) and gibberellic-acid-mediated signaling regulator (OsGID2) was upregulated significantly in GA 50 mu M + WBPH after 36 h. OsGAI was upregulated in the control, GA 50 mu M + WBPH, GA 100 mu M + WBPH, and MeJA 100 mu M + WBPH. However, after 48 h, the OsGID2 was significantly highly expressed in all groups of plants. The glutathione (GSH) values were significantly enhanced by GA 100 mu M and MeJA 50 mu M treatment. Unlike glutathione (GSH), the catalase (CAT) and peroxidase (POD) values were significantly reduced in control + WBPH plants. However, a slight increase in CAT and POD values was observed in GA 50 + WBPH plants and a reduction in the POD value was observed in GA 100 mu M + WBPH and MeJA 50 mu M + WBPH plants. GA highly recovered the WBPH-affected rice plants, while no recovery was seen in MeJA-treated plants. MeJA was highly accumulated in control + WBPH, MeJA 50 mu M + WBPH, and GA 100 mu M + WBPH plants. The H2O2 accumulation was highly decreased in GA-treated plants, while extensive cell death was observed in MeJA-treated plants compared with GA-treated plants. From this study, we can conclude that the exogenous application of GA can overcome the effects of the WBPH and enhance resistance in rice. | Asif, Saleem; Jang, Yoon-Hee; Kim, Eun-Gyeong; Jan, Rahmatullah; Asaf, Sajjad; Aaqil Khan, Muhammad; Farooq, Muhammad; Lubna; Kim, Nari; Lee, In-Jung; Kim, Kyung-Min | Kyungpook Natl Univ, Grad Sch, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Abdul Wali Khan Univ, Dept Bot, Garden Campus, Mardan 23200, Pakistan | ; Jan, Rahmatullah/AIC-3439-2022; Khan, Muhammad/ABB-9797-2021; Kim, Kyung-Min Kim/C-7007-2014; Asaf, Sajjad/ABA-3647-2021; Lee, In-Jung/GLS-0432-2022 | 57396413700; 57219901992; 57221496070; 57201981969; 56595059900; 57188585606; 57215544380; 57200621537; 57395985700; 16425830900; 34868260300 | kkm@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 23 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 0.8 | 2025-06-25 | 10 | 9 | exogenous hormones; white-backed planthoppers; gibberellic acid and methyl jasmonate; antioxidant; biotic stress | DISEASE DEVELOPMENT; BROWN PLANTHOPPER; OXIDATIVE STRESS; SALICYLIC-ACID; DEFENSE; EXPRESSION; GENE; ACCUMULATION; PROTEIN; PLANTS | antioxidant; biotic stress; exogenous hormones; gibberellic acid and methyl jasmonate; white-backed planthoppers | Animals; Glutathione; Hemiptera; Hormones; Hydrogen Peroxide; Oryza; catalase; chlorophyll; diaminobenzidine; diminazene aceturate; gibberellic acid; glutathione; hydrogen peroxide; jasmonic acid methyl ester; peroxidase; gibberellic acid; glutathione; hormone; hydrogen peroxide; jasmonic acid methyl ester; abiotic stress; agronomic trait; Article; bioaccumulation; biotic stress; cell death; chlorophyll content; controlled study; gene expression; nonhuman; osgai gene; osgid2 gene; oxidative stress; plant gene; plant stress; planthopper; regulator gene; rice; signal transduction; trypan blue assay; upregulation; animal; genetics; Hemiptera; metabolism; Oryza | English | 2022 | 2022-12 | 10.3390/ijms232314737 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | TNF-α-Mediated RIPK1 Pathway Participates in the Development of Trigeminal Neuropathic Pain in Rats | Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) participates in the regulation of cellular stress and inflammatory responses, but its function in neuropathic pain remains poorly understood. This study evaluated the role of RIPK1 in neuropathic pain following inferior alveolar nerve injury. We developed a model using malpositioned dental implants in male Sprague Dawley rats. This model resulted in significant mechanical allodynia and upregulated RIPK1 expression in the trigeminal subnucleus caudalis (TSC). The intracisternal administration of Necrosatin-1 (Nec-1), an RIPK1 inhibitor, blocked the mechanical allodynia produced by inferior alveolar nerve injury The intracisternal administration of recombinant rat tumor necrosis factor-alpha (rrTNF-alpha) protein in naive rats produced mechanical allodynia and upregulated RIPK1 expression in the TSC. Moreover, an intracisternal pretreatment with Nec-1 inhibited the mechanical allodynia produced by rrTNF-alpha protein. Nerve injury caused elevated TNF-alpha concentration in the TSC and a TNF-alpha block had anti-allodynic effects, thereby attenuating RIPK1 expression in the TSC. Finally, double immunofluorescence analyses revealed the colocalization of TNF receptor and RIPK1 with astrocytes. Hence, we have identified that astroglial RIPK1, activated by the TNF-alpha pathway, is a central driver of neuropathic pain and that the TNF-alpha-mediated RIPK1 pathway is a potential therapeutic target for reducing neuropathic pain following nerve injury. | Son, Jo Young; Ju, Jin Sook; Kim, Yu Mi; Ahn, Dong Kuk | Kyungpook Natl Univ, Sch Dent, Dept Oral Physiol, 2177 Dalgubeol Daero, Daegu 41940, South Korea | 57201998311; 7202751199; 57816812300; 7202706889 | n-violetjy@nate.com;jsju@knu.ac.kr;boboatom@naver.com;dkahn@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 0.8 | 2025-06-25 | 11 | 9 | RIPK1; inferior alveolar nerve injury; mechanical allodynia; TNF-alpha; trigeminal neuropathic pain | MECHANICAL ALLODYNIA; KINASE; COMPRESSION; EXPRESSION; BEHAVIOR; HYPERALGESIA; NOCICEPTION; CROSSROADS; ACTIVATION; ROLES | Inferior alveolar nerve injury; Mechanical allodynia; RIPK1; TNF-α; Trigeminal neuropathic pain | Animals; Astrocytes; Disease Models, Animal; Gene Expression Regulation; Hyperalgesia; Male; Neuralgia; Rats; Rats, Sprague-Dawley; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Trigeminal Neuralgia; Tumor Necrosis Factor-alpha; protein serine threonine kinase; tumor necrosis factor; receptor interacting protein serine threonine kinase; RIPK1 protein, rat; tumor necrosis factor; allodynia; animal experiment; animal model; Article; astrocyte; caudal trigeminal nucleus; cell activation; controlled study; immunofluorescence; implantation; inferior alveolar nerve; mechanical allodynia; nerve injury; neuropathic pain; nonhuman; protein function; rat; Western blotting; animal; disease model; gene expression regulation; genetics; hyperalgesia; male; metabolism; neuralgia; signal transduction; Sprague Dawley rat; trigeminus neuralgia | English | 2022 | 2022-01 | 10.3390/ijms23010506 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Transcriptional Control of Trpm6 by the Nuclear Receptor FXR | Farnesoid x receptor (FXR) is a nuclear bile acid receptor that belongs to the nuclear receptor superfamily. It plays an essential role in bile acid biosynthesis, lipid and glucose metabolism, liver regeneration, and vertical sleeve gastrectomy. A loss of the FXR gene or dysregulations of FXR-mediated gene expression are associated with the development of progressive familial intrahepatic cholestasis, tumorigenesis, inflammation, and diabetes mellitus. Magnesium ion (Mg2+) is essential for mammalian physiology. Over 600 enzymes are dependent on Mg2+ for their activity. Here, we show that the Trpm6 gene encoding a Mg2+ channel is a direct FXR target gene in the intestinal epithelial cells of mice. FXR expressed in the intestinal epithelial cells is absolutely required for sustaining a basal expression of intestinal Trpm6 that can be robustly induced by the treatment of GW4064, a synthetic FXR agonist. Analysis of FXR ChIP-seq data revealed that intron regions of Trpm6 contain two prominent FXR binding peaks. Among them, the proximal peak from the transcription start site contains a functional inverted repeat 1 (IR1) response element that directly binds to the FXR-RXR alpha heterodimer. Based on these results, we proposed that an intestinal FXR-TRPM6 axis may link a bile acid signaling to Mg2+ homeostasis. | Kim, Eun Young; Lee, Jae Man | Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Biochem & Cell Biol, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, BK21 FOUR KNU Biomed Convergence Program, Daegu 41944, South Korea | ; Kim, YoungHwan/B-2395-2013; Lee, Jae/KFF-5361-2024 | 57194632567; 47461355200 | key11@knu.ac.kr;jaemanlee@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 0.62 | 2025-06-25 | 6 | 7 | nuclear receptor; FXR; bile acid; Trpm6; small intestine; colon; magnesium | FARNESOID-X-RECEPTOR; BILE-ACID RECEPTOR; SECONDARY HYPOCALCEMIA; LIVER; HYPOMAGNESEMIA; ACTIVATION; MICE; IDENTIFICATION; CHOLESTEROL; SENSITIVITY | Bile acid; Colon; FXR; Magnesium; Nuclear receptor; Small intestine; Trpm6 | Animals; Base Sequence; Bile Acids and Salts; Cell Line, Tumor; Epithelial Cells; Gene Expression Regulation; HeLa Cells; Humans; Intestines; Introns; Magnesium; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Response Elements; Transcription Initiation Site; Transcription, Genetic; TRPM Cation Channels; bile acid; cell nucleus receptor; farnesoid X receptor; G protein coupled receptor; genomic DNA; glucose; magnesium ion; retinoid X receptor alpha; small interfering RNA; testosterone; transcriptome; transient receptor potential channel M6; bile acid; cell receptor; farnesoid X-activated receptor; magnesium; transient receptor potential channel M; Trpm6 protein, mouse; animal cell; animal experiment; Article; bile acid synthesis; bioinformatics; cholestasis; chromatin immunoprecipitation sequencing; controlled study; diabetes mellitus; DNA responsive element; enzyme activity; female; gene expression; genetic transcription; genetic transfection; glucose metabolism; homeostasis; human; intrahepatic cholestasis; lipid metabolism; liver metabolism; liver regeneration; male; microarray analysis; molecular cloning; mouse; nonhuman; oxidative phosphorylation; protein expression; real time polymerase chain reaction; reverse transcription polymerase chain reaction; RNA sequence; signal transduction; sleeve gastrectomy; small intestine; transcription initiation site; upregulation; animal; C57BL mouse; epithelium cell; gene expression regulation; genetics; HeLa cell line; intestine; intron; knockout mouse; metabolism; nucleotide sequence; physiology; tumor cell line | English | 2022 | 2022-02 | 10.3390/ijms23041980 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Usage of IR Sensors in the HVAC Systems, Vehicle and Manufacturing Industries: A Review | The use of thermal sensors is increasing in response to dealing with the problems of the visible light spectrum. These sensors measure the temperature of the object and convert it to some readable output. There is a diverse range of temperature sensors, and different sensors are used for different purposes. The choice of the sensor depends on the cost of the sensor, resolution, and level of accuracy. For instance, an IR camera combined with the RGB sensor can produce better human activity recognition. However, increase the cost of the machine. For some applications, a high resolution is not required and a low-cost sensor can satisfy the need. In this survey, we discuss the employment of thermal sensors in HVAC systems, vehicle, and manufacturing industries as they are heavily used in these industries. We reported the types of available thermal sensors and the sensors commonly used in each industry. This is followed by a comprehensive review of the application-specific methods. In the end, we may say that the selection of the thermal sensor has much importance as well as the choice of the suitable algorithms according to the given conditions to avail the maximum accuracy in our results. | Altaf, Muhammad Adeel; Ahn, Jongsik; Khan, Danish; Kim, Min Young | Kyungpook Natl Univ, Sch Elect & Elect Engn, Deagu 41566, South Korea; Hanwha Syst, Intelligence SW Team, Pangyo 13524, South Korea; Kyungpook Natl Univ, Ctr ICT & Automot Convergence, Deagu 41566, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Res Ctr Neurosurg Robot Syst, Deagu 41566, South Korea | ; Khan, Danish/AAW-6708-2021; Altaf, Muhammad Adeel/AGR-0409-2022 | 57609122300; 57223291728; 57200212320; 56739349100 | adeel.altaf88@knu.ac.kr;jongsik.ahn@hanwha.com;danish@knu.ac.kr;minykim@knu.ac.kr; | IEEE SENSORS JOURNAL | IEEE SENS J | 1530-437X | 1558-1748 | 22 | 10 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION;PHYSICS, APPLIED | 2022 | 4.3 | 23.0 | 0.34 | 2025-06-25 | 8 | 11 | Sensors; Detectors; Temperature sensors; Temperature measurement; Imaging; Intelligent sensors; Infrared detectors; Thermal sensors; infrared array sensors; thermal camera; RGB sensors; fusion; HVAC systems; autonomous driving system | OCCUPANCY ESTIMATION; INFRARED DETECTORS; FAULT-DETECTION; FLOW DETECTION; TRACKING | Autonomous driving system; Fusion; HVAC systems; Infrared array sensors; RGB sensors; Thermal camera; Thermal sensors | Cameras; Costs; Infrared devices; Manufacture; Temperature sensors; Array sensors; Autonomous driving; Autonomous driving system; Driving systems; HVAC system; Infrared array sensor; Infrared arrays; Intelligent sensors; RGB sensor; Thermal camera; Thermal sensors; Temperature measurement | English | 2022 | 2022-05-15 | 10.1109/jsen.2022.3166190 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | A comprehensive review on techniques used in conversion of biomass into bioeconomy | In the modern world, the major problems humanity faces, such as exploitation of depleting natural resources, rising population, combined with other environmental and economic challenges, shift our attention towards the booming sector such as bioeconomy. The bioeconomy is a bio-based economy or the knowledge-based bioeconomy (KBBE) where the basic building blocks for materials, chemicals, and energy are developed from renewable biological resources, such as plant and animal sources. The bioeconomy contributes to increased energy sources and material production which has a less hazardous impact on the environment. Numerous wastes are dumped on to earth's surface that can be converted into various bio-economic products. Microbes are primarily utilized to convert wastes into bioeconomy products, which needs several influencing conditions for the conversion process. The present review will unravel the potential impact of the bioeconomy and its history; this study also deals with the current status and future perspective of the bioeconomy. | Swetha, T. Angelin; Mohanrasu, K.; Sudhakar, Muniyasamy; Raja, Rathinam; Ponnuchamy, Kumar; Muthusamy, Govarthanan; Arun, A. | Alagappa Univ, Dept Microbiol, Bioenergy & Bioremediat Lab, Karaikkudi, Tamil Nadu, India; Univ Newcastle, Global Innovat Ctr Adv Nanomat GICAN, Callaghan, NSW 2308, Australia; CSIR Chem Cluster, Adv Polymers & Composites Res, Pretoria, South Africa; Nelson Mandela Univ, Dept Chem, Port Elizabeth, South Africa; Bharath Inst Higher Educ & Res BIHER, Sree Balaji Med Coll & Hosp SBMCH, Res & Dev Wing, Chennai 600044, Tamil Nadu, India; Alagappa Univ, Dept Anim Hlth & Management, Karaikkudi 630003, Tamil Nadu, India; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Saveetha Dent Coll & Hosp, Saveetha Inst Med & Tech Sci, Dept Biomat, Chennai 600077, Tamil Nadu, India | ; Muniyasamy, Sudhakar/K-8592-2015; Arun, Alagarsamy/F-8986-2019; Ponnuchamy, Kumar/D-3470-2013; Arun, A./F-8986-2019; Govarthanan, Muthusamy/C-1491-2014; Muthusamy, Govarthanan/C-1491-2014; Muniyasamy, Sudhakar/AAH-6879-2019 | 57204759900; 57202300780; 57226007770; 16029399900; 55173720800; 54881927600; 57078221100 | arunalacha@gmail.com; | SUSTAINABLE ENERGY TECHNOLOGIES AND ASSESSMENTS | SUSTAIN ENERGY TECHN | 2213-1388 | 2213-1396 | 53 | SCIE | ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2022 | 8 | 23.1 | 1.2 | 2025-06-25 | 18 | 20 | Bioeconomy; Anaerobic digestion; Torrification; Pyrolysis; Gasification | MICROBIAL FUEL-CELLS; CONTINUOUS ELECTRICITY-GENERATION; WASTE-WATER TREATMENT; ANAEROBIC-DIGESTION; MEDIATOR-LESS; FAST PYROLYSIS; HYDROGEN; GASIFICATION; KINETICS; TORREFACTION | Anaerobic digestion; Bioeconomy; Gasification; Pyrolysis; Torrification | Knowledge based systems; Basic building block; Bio-based; Biological resources; Booming sector; Economic challenges; Energy; Energy materials; Environmental challenges; Knowledge based; Torrification; Anaerobic digestion | English | 2022 | 2022-10 | 10.1016/j.seta.2022.102682 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Advanced thermochemical conversion of algal biomass to liquid and gaseous biofuels: A comprehensive review of recent advances | Algal biomass is considered to be one of the most promising feedstocks of importance for conversion into biofuels. With their benefits over other biomass feedstocks, such as sustainability, renewability and productivity, microalgae are one of the most promising biomass resources for use in thermochemical conversion processes. With this review, we hope to present the most recent information available on the commonly used thermochemical conversion procedures, which are hydrothermal liquefaction, pyrolysis, and gasification processes. The study evaluated both the quality and yield of liquid products (bio-oil) as well as gaseous products (syngas) derived by thermochemical conversion processes, to truly comprehend the effectiveness and feasibility of each method. It was found that the yield of bio-oil obtained through hydrothermal liquefaction was lower than the yield achieved through pyrolysis. However, the energy density, fuel properties and storage stability of hydrothermal liquefaction bio-oil are superior to those of pyrolysis bio-oil. This study also demonstrated that the gasification process has been the most energy-saving approach for the transformation of microalgae to syngas. Microalgae supercritical water gasification might be a good way to turn microalgae into high-heating-value gas without having to dry it first. Finally, the prospects and obstacles of converting microalgal biomass to biofuels were discussed. Overall, the purpose of this work is to present a comprehensive assessment of the most recent developments in microalgal biomass thermochemical conversion for the production of liquid and gaseous biofuels. | Krishnan, Radhakrishnan Yedhu; Manikandan, Sivasubramanian; Subbaiya, Ramasamy; Kim, Woong; Karmegam, Natchimuthu; Govarthanan, Muthusamy | Amal Jyothi Coll Engn, Dept Food Technol, Kottayam 686518, Kerala, India; Saveetha Inst Med & Tech Sci SIMATS, Saveetha Sch Engn, Dept Biotechnol, Chennai 602105, Tamil Nadu, India; Copperbelt Univ, Sch Math & Nat Sci, Dept Biol Sci, Jambo Dr,POB 21692, Kitwe, Zambia; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Govt Arts Coll Autonomous, Dept Bot, Salem 636007, Tamil Nadu, India | Natchimuthu, Karmegam/J-4745-2019; Krishnan, Radhakrishnan/K-7885-2016; Muthusamy, Govarthanan/C-1491-2014; Govarthanan, Muthusamy/C-1491-2014; Karmegam, Natchimuthu/J-4745-2019; Subbaiya, R/AAR-2948-2021; S, Manikandan/GZM-7135-2022 | 57198186588; 55213168500; 55263515700; 55581636400; 6506043230; 54881927600 | kanishkarmegam@gmail.com;gova.muthu@gmail.com; | SUSTAINABLE ENERGY TECHNOLOGIES AND ASSESSMENTS | SUSTAIN ENERGY TECHN | 2213-1388 | 2213-1396 | 52 | SCIE | ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2022 | 8 | 23.1 | 3.11 | 2025-06-25 | 44 | 52 | Microalgae; Bio-oil; Syngas; Hydrothermal liquefaction; Pyrolysis; Gasification | SUPERCRITICAL WATER GASIFICATION; BIO-OIL PRODUCTION; LOW-LIPID MICROALGAE; HYDROTHERMAL LIQUEFACTION; CATALYTIC PYROLYSIS; HYDROGEN-PRODUCTION; NANNOCHLOROPSIS-GADITANA; MICROWAVE PYROLYSIS; GRACILARIA-GRACILIS; CO-PYROLYSIS | Bio-oil; Gasification; Hydrothermal liquefaction; Microalgae; Pyrolysis; Syngas | Biofuels; Biomass; Calorific value; Energy conservation; Feedstocks; Fuel storage; Gasification; Liquefaction; Liquids; Microorganisms; Pyrolysis; Synthesis gas; Algal biomass; Bio-oils; Biomass feedstock; Biomass To Liquid; Conversion process; Gasification process; Hydrothermal liquefactions; Microalgal biomass; Syn gas; Thermochemical Conversion; algal bloom; biofuel; biomass; liquefaction; microalga; thermochemistry; Microalgae | English | 2022 | 2022-08 | 10.1016/j.seta.2022.102211 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Investigation of free and forced vortex induced thermal energy exchange potential | Recently, the gravitational water vortex flow capability to exchange heat to another fluid that circulates on the outer surface of the basin has been explored by constructing spiral flow channels (SFC). Because of the roller coaster effect, the time and area of contact between the two separate fluid streams for the sole purpose of thermal exchange limited the heat transfer. The present study proposes a new configuration that circulates the hot water in a shell with baffles (SWB) configuration around the basin. Moreover, the effect of a mixer driven by a gravitational water vortex has also been investigated to further enhance the heat transfer without the application of any external power. In short, the present study investigates and compare the heat exchange characteristics of an artificially induced free and forced vortex heat exchanger of both configurations. Each configuration has been tested by varying the hot side mass flow rates as 0.15, 0.25, 0.39, 0.7, 1.23 and 2.4 kg/s. For each mass flow rate maintained on the colder side, i.e., 0.6, 0.7, 0.8, 0.9, 1 and 1.1 kg/s, to determine the outlet temperatures of both sides. Results show that the SWB configuration for the same operating conditions is 1.32 times more effective in exchanging heat than SFC configuration. The presence of a mixer on the colder side decreases the heat transfer rate with a recorded maximum temperature drop of 2.5 K of the cold fluid. Moreover, the heat flux exchanged in the absence of a mixer for SWB and SFC configurations is 2.1 times and 1.32 times greater than those in the presence of the mixer, respectively. Therefore, the presence of the mixer on the colder side is not suitable for heat transfer enhancement in gravitational water vortex flow. | Riaz, Muhammad Talha; Cheema, Taqi Ahmad; Tayyab, Muhammad; Khan, Ali Ul Atas; Amber, Khuram Pervez; Sajid, Muhammad Bilal; Park, Cheol Woo | GIK Inst Engn Sci & Technol, Fac Mech Engn, Topi 23460, Pakistan; Mirpur Univ Sci & Technol MUST, Dept Mech Engn, Mirpur 10250, Ajk, Pakistan; Natl Univ Sci & Technol NUST, US Pakistan Ctr Adv Studies Energy USPCAS E, Sect H-12, Islamabad, Pakistan; Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea | ; Tayyab, Muhammad/HIR-8111-2022; AMBER, KHURAM/LXB-2584-2024; Sajid, Muhammad Bilal/GQH-8124-2022 | 57471680700; 36522492600; 58793345200; 57471917200; 55944660900; 57529993200; 7408416474 | tacheema@giki.edu.pk;chwoopark@knu.ac.kr; | SUSTAINABLE ENERGY TECHNOLOGIES AND ASSESSMENTS | SUSTAIN ENERGY TECHN | 2213-1388 | 2213-1396 | 52 | SCIE | ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2022 | 8 | 23.1 | 0.3 | 2025-06-25 | 4 | 5 | Gravitational water vortex heat exchanger; Mixer; Forced vortex; Energy balance; Shell with baffles; Spiral flow channel | SOLAR AIR HEATER; RIB ROUGHNESS; PERFORMANCE; TUBE | Energy balance; Forced vortex; Gravitational water vortex heat exchanger; Mixer; Shell with baffles; Spiral flow channel | Channel flow; Heat exchangers; Heat flux; Heat transfer; Mass transfer; Mixers (machinery); Baffle configurations; Channel configuration; Cold side; Flow channels; Forced vortex; Gravitational water vortex heat exchanger; Mass-flow rate; Shell with baffle; Spiral flow; Spiral flow channel; energy balance; equipment; flow field; heat production; heat transfer; machinery; vortex flow; water flow; Vortex flow | English | 2022 | 2022-08 | 10.1016/j.seta.2022.102107 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Does precutting prior to endoscopic piecemeal resection of large colorectal neoplasias reduce local recurrence? A KASID multicenter study | Background It would be expected that local recurrence could be reduced by performing precutting (with sufficient margins) prior to endoscopic piecemeal mucosal resection (EPMR). We explored the clinical outcomes and local recurrence after precutting EPMR of large colorectal neoplasias. Methods Between January 2005 and December 2015, in total, 223 patients with colorectal neoplasias >= 2 cm in diameter removed via EPMR in four tertiary hospitals were enrolled. The patients were divided into a precut EPMR group (n = 62) and a non-precut EPMR group (n = 161). We retrospectively evaluated clinical outcomes and factors associated with local recurrence. Results The mean total procedure time was significantly shorter in the non-precut EPMR group than in the precut EPMR group. However, the number of pieces, and the complete resection and recurrence rates, did not differ significantly [for the latter, precut 8.1% vs. non-precut 9.9%, P = 0.668]. The complete resection rate, number of pieces, and use of argon plasma coagulation (APC) were significantly associated with the local recurrence rate on univariate analysis. In the Cox's proportional hazards model, prophylactic APC [hazard ratio 0.307, 95% confidence interval (CI) 0.114-0.823; P = 0.019] and complete resection rate (odds ratio 0.083, 95% CI 0.011-0.655; P = 0.018) were significantly associated with the local recurrence rate. Conclusion Precutting prior to EPMR did not significantly reduce the local recurrence rate or the number of resected pieces. Histologically complete resection, reducing the number of pieces, and prophylactic APC seem to be important in terms of reducing local recurrence. | Yoon, Hong Jin; Sohn, Dae Kyung; Jung, Yunho; Lee, Hyun Seok; Koo, Hoon Sup; Kim, Kyeong Ok; Shin, Jeong Eun; Kim, Hyun Gun; Chung, Il Kwun; Hwangbo, Young | Soonchunhyang Univ, Dept Internal Med, Div Gastroenterol, Coll Med, 31 Suncheonhyang 6 Gil, Cheonan 31151, South Korea; Natl Canc Ctr, Ctr Colorectal Canc, Res Inst & Hosp, Goyang, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Konyang Univ, Dept Internal Med, Coll Med, Daejeon, South Korea; Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Dankook Univ, Dept Internal Med, Coll Med, Cheonan, South Korea; Soonchunhyang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Soonchunhyang Univ, Dept Prevent Med, Coll Med, 31 Suncheonhyang 6 Gil, Cheonan 31151, South Korea | Lee, Hyun/D-5004-2011; Jung, Yunho/AGN-4564-2022 | 57125322900; 12447054500; 54789008200; 36647886100; 36523211900; 53363798100; 55239527500; 35285751400; 59436748700; 55926551700 | yunho7575@gmail.com;hbyoung@sch.ac.kr; | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | SURG ENDOSC | 0930-2794 | 1432-2218 | 36 | 5 | SCIE | SURGERY | 2022 | 3.1 | 23.2 | 0.62 | 2025-06-25 | 1 | 3 | Endoscopic mucosal resection; Colonic tumor; Piecemeal resection | MUCOSAL RESECTION; SUBMUCOSAL DISSECTION; RISK-FACTORS; COLONIC POLYPS; EFFICACY; TUMORS; EMR | Colonic tumor; Endoscopic mucosal resection; Piecemeal resection | Colonoscopy; Colorectal Neoplasms; Endoscopic Mucosal Resection; Humans; Intestinal Mucosa; Neoplasm Recurrence, Local; Retrospective Studies; Treatment Outcome; adult; argon plasma coagulation; Article; bleeding; cancer recurrence; clinical outcome; colorectal tumor; endoscopic piecemeal mucosal resection; endoscopic surgery; female; follow up; human; major clinical study; male; multicenter study; perforation; recurrence risk; retrospective study; clinical trial; colonoscopy; endoscopic mucosal resection; intestine mucosa; pathology; prevention and control; procedures; treatment outcome; tumor recurrence | English | 2022 | 2022-05 | 10.1007/s00464-021-08664-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Double tract reconstruction versus double flap technique: short-term clinical outcomes after laparoscopic proximal gastrectomy for early gastric cancer | Background Laparoscopic proximal gastrectomy (LPG) is increasingly preferred for operative management of early gastric cancer, although there is no consensus on a standard reconstruction method after resection. Two popular methods used after LPG are double tract reconstruction (DTR) and double flap technique (DFT). This study assessed comprehensive clinical outcomes including quality of life (QoL) and body composition change 1 year after DFT and DTR. Methods We retrospectively reviewed prospectively collected data from 51 to 18 patients who underwent DTR and DFT, respectively, between September 2014 and December 2018. Short-term surgical outcomes, presence of reflux esophagitis, nutritional supplementation, medications, nutritional status (laboratory results and body composition analysis), and QoL measured preoperatively and at 1 year postoperatively were compared between both groups. Results Both groups did not differ significantly in clinicopathological characteristics. The DFT as compared to the DTR group required significantly longer time for anastomosis (79.4 vs. 60.9 min, p < 0.001) and use of fewer staplers (3.39 vs. 6.86, p < 0.001). While the presence of endoscopic reflux esophagitis and iron/vitamin B-12 replacement were comparable, the DTR group showed a higher tendency of taking anti-reflux medications for reflux symptoms (DTR: 13.7% vs. DFT: 0.0%, p = 0.177). The DTR group lost significantly more weight (p = 0.038) and body fat (p = 0.009). QoL analysis showed significant deterioration in diarrhea, eating restriction, and taste problems in both groups (DTR group: p = 0.008, p < 0.001, p = 0.010, respectively, and DFT group: p = 0.017, p = 0.024, p = 0.034, respectively). However, only the DTR group showed significant deterioration in physical function (p = 0.009), role function (p = 0.033), nausea/vomiting (p = 0.041), appetite loss (p = 0.019), dysphagia (p = 0.001), pain (p = 0.025), and body image (p = 0.004). Conclusions Despite requiring a longer anastomosis time, performing DFT after LPG was shown to be an ideal reconstruction method in terms of better 1-year QoL and nutritional outcome. Further larger studies over longer postoperative periods are necessary to confirm our findings. | Yu, Byunghyuk; Park, Ki Bum; Park, Ji Yeon; Lee, Seung Soo; Kwon, Oh Kyoung; Chung, Ho Young; Hwang, Yoon Jin | Kyungpook Natl Univ, Intens Care Unit, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Gastr Canc Ctr, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Hepatobiliary Pancreat Ctr, Chilgok Hosp, Daegu, South Korea | Yu, Byunghyuk/HGB-0950-2022; Park, Ji Yeon/AAV-2471-2020 | 57208745241; 57220965452; 57196405216; 54400392100; 26536109900; 56008255800; 7402310967 | okugisurg@knu.ac.kr; | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | SURG ENDOSC | 0930-2794 | 1432-2218 | 36 | 7 | SCIE | SURGERY | 2022 | 3.1 | 23.2 | 4.15 | 2025-06-25 | 23 | 20 | Stomach neoplasm; Proximal gastrectomy; Esophagogastrostomy | QUALITY-OF-LIFE; STUMP CARCINOMA | Esophagogastrostomy; Proximal gastrectomy; Stomach neoplasm | Anastomosis, Surgical; Esophagitis, Peptic; Gastrectomy; Humans; Laparoscopy; Postoperative Complications; Quality of Life; Retrospective Studies; Stomach Neoplasms; Treatment Outcome; antineoplastic agent; cholesterol; cobalamin; cyanocobalamin; ferritin; hemoglobin; iron; serum albumin; transferrin; abdominal abscess; adjuvant chemotherapy; adjuvant therapy; adult; age; American Society of Anaesthesiologists score; anastomosis; anastomosis leakage; anastomotic stenosis; anxiety disorder; Article; balloon dilatation; body composition; body fat; body image; body mass; body weight; cancer diagnosis; cancer surgery; cholesterol blood level; clinical article; clinical feature; clinical outcome; comparative study; diarrhea; diet restriction; diet supplementation; disease classification; double flap technique; double tract reconstruction; dysphagia; early cancer; endoscopic submucosal dissection; esophagogastrostomy; European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30; female; heartburn; human; intermethod comparison; intestine obstruction; iron blood level; iron therapy; laparoscopic surgery; laparotomy; length of stay; Los Angeles classification; loss of appetite; lymph node dissection; male; nutritional status; operation duration; operative blood loss; percutaneous drainage; postoperative complication; postoperative nausea and vomiting; postoperative pain; prevalence; prospective study; proximal gastrectomy; questionnaire; reflux esophagitis; reoperation; retrospective study; sex; short term survival; small intestine obstruction; stenosis; stomach cancer; surgical technique; taste disorder; tumor localization; tumor volume; vitamin blood level; xerostomia; gastrectomy; laparoscopy; pathology; postoperative complication; procedures; quality of life; reflux esophagitis; stomach tumor; treatment outcome | English | 2022 | 2022-07 | 10.1007/s00464-021-08902-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effect of conservative levator veli palatini dissection on palatoplasty: A retrospective cohort study | Kim, Yun Hyun; Ryu, Jeong Yeop; Lee, Joon Seok; Yang, Jung Dug; Chung, Ho Yun; Cho, Byung Chae; Choi, Kang Young | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, Daegu, South Korea | LEE, JIN/Q-3108-2018; Yang, Jung/R-7806-2019; Ryu, Jeong Yeop/GLQ-9419-2022 | 57212668506; 56366349400; 56496041000; 55171704700; 7404007181; 55662871100; 57203745682 | kychoi@knu.ac.kr; | JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY | J CRANIO MAXILL SURG | 1010-5182 | 1878-4119 | 50 | 9 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE;SURGERY | 2022 | 3.1 | 23.2 | 0 | 2025-06-25 | 0 | 0 | CLEFT; REPAIR | Cleft Palate; Humans; Palatal Muscles; Palate, Soft; Reconstructive Surgical Procedures; Retrospective Studies; local anesthetic agent; Article; child; cohort analysis; controlled study; dissection; female; human; levator veli palatini; major clinical study; male; nasalance; nasality; palatoplasty; preschool child; retrospective study; skeletal muscle; surgical patient; surgical technique; vowel; cleft palate; palate muscle; reconstructive surgery; soft palate | English | 2022 | 2022-09 | 10.1016/j.jcms.2022.09.002 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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