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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | New Conditions on Normal Jacobi Operator of Real Hypersurfaces in the Complex Quadric | On a real hypersurface M of a complex quadric we have an almost contact metric structure induced by the Kahlerian structure of the ambient space. Therefore, on M we have the Levi-Civita connection del and, for any non-null real number k, the so called kth generalized Tanaka Webster connection (del) over cap ((k)). We introduce the notions of((del) over cap ((k)), del)-Codazzi and ((del) over cap ((k)), del)-Killing normal Jacobi operator on such a real hypersurface and classify Hopf real hypersurface in a complex quadric whose normal Jacobi operators satisfy any of both conditions. | Perez, Juan de Dios; Suh, Young Jin | Univ Granada, Dept Geometria & Topol, Granada 18071, Spain; Univ Granada, IEMATH, Granada 18071, Spain; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Kyungpook Natl Univ, RIRCM, Daegu 41566, South Korea | ; de Dios Perez, Juan/B-7768-2015 | 57205268627; 7202260479 | jdperez@ugr.es;yjsuh@knu.ac.kr; | BULLETIN OF THE MALAYSIAN MATHEMATICAL SCIENCES SOCIETY | B MALAYS MATH SCI SO | 0126-6705 | 2180-4206 | 44 | 2 | SCIE | MATHEMATICS | 2021 | 1.397 | 24.2 | 0.89 | 2025-07-30 | 4 | 4 | Complex quadric; Real hypersurface; Normal Jacobi operator; kth generalized Tanaka Webster connection; ((del)over-cap((k)), del)-Codazzi normal Jacobi operator; ((del)over-cap((k)), del)-Killing normal Jacobi operator | (∇ ^ <sup>(</sup><sup>k</sup><sup>)</sup>, ∇) -Codazzi normal Jacobi operator; (∇ ^ <sup>(</sup><sup>k</sup><sup>)</sup>, ∇) -Killing normal Jacobi operator; Complex quadric; kth generalized Tanaka Webster connection; Normal Jacobi operator; Real hypersurface | English | 2021 | 2021-03 | 10.1007/s40840-020-00988-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Rapid Molecular Tests for Detecting Respiratory Pathogens Reduced the Use of Antibiotics in Children | Multiplex polymerase chain reaction (mPCR) is increasingly being used to diagnose infections caused by respiratory pathogens in pediatric inpatient facilities. mPCR assays detect a broader array of viruses, with higher specificity and sensitivity and faster turnaround than previous assays. We adapted the FilmArray Respiratory Panel (FA-RP) for diagnosing respiratory infections. FA-RP is an in vitro mPCR assay that simultaneously and rapidly (in about 1 h) detects 20 pathogens directly from respiratory specimens. Here, we studied the clinical efficacy of FA-RP in children who underwent testing for respiratory pathogens at Yeungnam University Hospital from November 2015 to August 2018. From November 2015 to June 2016, routine mPCR testing was performed on nasopharyngeal swabs using the routine mPCR kit. From November 2016 to July 2018, mPCR testing was performed using FA-RP. A total of 321 tests by routine mPCR and 594 tests by FA-RP were included. The positive detection rates for routine mPCR and FA-RP were 71.3% and 83.3%, respectively. FA-RP reduced the lead time, waiting time, turnaround time, intravenous (IV) antibiotic use, and length of hospital stay for pediatric patients. The decreased use of antibiotics is expected to reduce antibiotic resistance in children. | Kim, Yu Kyung; Lee, Jong Ho; Kim, Sae Yoon; Ahn, Ji Young; Choi, Kwang Hae; Lee, Young Hwan; Jang, Kyung Mi; Hau, Yong Sauk; Lee, Jae Min | Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu 41944, South Korea; Yeungnam Univ, Coll Med, Dept Lab Med, Daegu 42415, South Korea; Yeungnam Univ, Coll Med, Dept Pediat, Daegu 42415, South Korea; Yeungnam Univ, Sch Business, Dept Business Adm, Gyongsan 38541, South Korea | Lee, Jae Min/H-8475-2013; ahn, jiyoung/KSM-2201-2024; Kim, Young-Il/ISS-7678-2023 | 9237571900; 57193676397; 53984438900; 57204718185; 55040976900; 57203798781; 57203762745; 26424630600; 39261799700 | kimyg@knu.ac.kr;leejongho@ynu.ac.kr;sysnow88@hanmail.net;jy4413@gmail.com;choi8819@gmail.com;yhlee@med.yu.ac.kr;fortune001j@gmail.com;augustine@yu.ac.kr;mopic@hanmail.net; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 10 | 3 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2021 | 5.222 | 24.2 | 1.23 | 2025-07-30 | 11 | 13 | acute respiratory infection; antimicrobials; multiplex polymerase chain reaction; respiratory pathogen; FilmArray Respiratory Panel | COMMUNITY-ACQUIRED PNEUMONIA; REQUIRING HOSPITALIZATION; INFECTIONS; IMPACT; PANEL | Acute respiratory infection; Antimicrobials; FilmArray Respiratory Panel; Multiplex polymerase chain reaction; Respiratory pathogen | antibiotic agent; C reactive protein; procalcitonin; Adenoviridae; alanine aminotransferase level; antibiotic resistance; Article; aspartate aminotransferase level; Bordetella pertussis; bronchiolitis; child; Chlamydia pneumoniae; cohort analysis; Coronavirinae; croup; diagnostic test accuracy study; drug therapy; Enterovirus; erythrocyte sedimentation rate; female; hemoglobin blood level; human; Human bocavirus; Human metapneumovirus; Human respiratory syncytial virus; Human rhinovirus; human tissue; infant; Influenza A virus; Influenza B virus; intravenous drug administration; lactate dehydrogenase blood level; length of stay; leukocyte count; lower respiratory tract infection; major clinical study; male; multiplex polymerase chain reaction; Mycoplasma pneumoniae; nasopharyngeal swab; Paramyxovirinae; pediatrics; platelet count; pneumonia; respiratory tract infection; respiratory virus; retrospective study; sensitivity and specificity; tonsillitis; turnaround time; upper respiratory tract infection; virus detection | English | 2021 | 2021-03 | 10.3390/antibiotics10030283 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Visible and Near-Infrared Image Acquisition and Fusion for Night Surveillance | Image fusion combines images with different information to create a single, information-rich image. The process may either involve synthesizing images using multiple exposures of the same scene, such as exposure fusion, or synthesizing images of different wavelength bands, such as visible and near-infrared (NIR) image fusion. NIR images are frequently used in surveillance systems because they are beyond the narrow perceptual range of human vision. In this paper, we propose an infrared image fusion method that combines high and low intensities for use in surveillance systems under low-light conditions. The proposed method utilizes a depth-weighted radiance map based on intensities and details to enhance local contrast and reduce noise and color distortion. The proposed method involves luminance blending, local tone mapping, and color scaling and correction. Each of these stages is processed in the LAB color space to preserve the color attributes of a visible image. The results confirm that the proposed method outperforms conventional methods. | Kwon, Hyuk-Ju; Lee, Sung-Hak | Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Deahakro, Daegu 702701, South Korea | 55169908300; 7601395661 | olin1223@ee.knu.ac.kr;shak2@ee.knu.ac.kr; | CHEMOSENSORS | CHEMOSENSORS | 2227-9040 | 9 | 4 | SCIE | CHEMISTRY, ANALYTICAL;ELECTROCHEMISTRY;INSTRUMENTS & INSTRUMENTATION | 2021 | 4.229 | 24.2 | 1.09 | 2025-07-30 | 16 | 20 | infrared; image fusion; tone mapping; luminance blending; night surveillance | Image fusion; Infrared; Luminance blending; Night surveillance; Tone mapping | Image acquisition; Image enhancement; Infrared imaging; Exposure fusions; Infrared image fusions; Luminance blending; Multiple exposure; Near- infrared images; Night surveillance; Surveillance systems; Tone mapping; Visible and near infrared; Wavelength band; Image fusion | English | 2021 | 2021-04 | 10.3390/chemosensors9040075 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Cancer-Associated Fibroblast Subgroups Showing Differential Promoting Effect on HNSCC Progression | Simple Summary It is generally accepted that fibroblasts represent a heterogeneous population of cells with different functions depending on the cell type. Although numerous reports have stated that cancer-associated fibroblast (CAF) promotes cancer progression, few studies have shown that they inhibit cancer progression. We propose that CAFs derived from some HNSCC patients is less effective in promoting cancer progression than CAFs from other patients and that specific collagen proteins may be involved in this process. Background: The critical effect of the tumor microenvironment on cancer progression is well recognized. Recent research suggests that the cancer-promoting properties of the tumor stroma may be attributed to fibroblasts. However, the effect of cancer-associated fibroblast (CAF) on the progression of head and neck squamous cell carcinoma (HNSCC) is not well known. Methods: From the immunohistochemical analysis of head and neck squamous cell carcinoma (HNSCC) tissues, we divided CAF into two groups depending on the presence or absence of a well-demarcated boundary between epithelial cancer cells and the surrounding extracellular matrix (ECM). Primary culture of CAF was performed, followed by co-transplantation with HNSCC cells into mice oral mucosa, and the tumorigenesis was compared. The mRNA expression patterns between these two CAF groups were compared using DNA microarray analysis. Results: CAFs from cancer tissues that showed no demarcation between ECM and epithelial cancer cells (CAF-Promote) tended to stimulate Matrigel invasion of HNSCC cells. Conversely, CAFs from cancer tissues that showed a boundary with epithelial cancer cells (CAF-Delay) caused no remarkable increase in Matrigel invasion. Compared with CAF-P, CAF-D is less effective in promoting FaDu tumorigenicity in the mouse model. In DNA microarray analysis, COL3A1 and COL6A6 showed particularly high expression in the CAF-D group. Conclusions: These cancer stroma-derived collagen proteins might delay the HNSCC progression. These findings are expected to provide vital information for predicting HNSCC prognosis and developing drug targets in the future. | Kang, Soo Hyun; Oh, Su Young; Lee, Heon-Jin; Kwon, Tae-Geon; Kim, Jin-Wook; Lee, Sung-Tak; Choi, So-Young; Hong, Su-Hyung | Kyungpook Natl Univ, Sch Dent, Dept Microbiol & Immunol, Daegu 700412, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Daegu 700412, South Korea | 57204021325; 57204016703; 36462383000; 35205433300; 55862646000; 55931708300; 57202918688; 8691449100 | black_bean@knu.ac.kr;oohsuy@knu.ac.kr;heonlee@knu.ac.kr;kwondk@knu.ac.kr;vocaleo@knu.ac.kr;st0907@knu.ac.kr;dentalchoi@knu.ac.kr;hongsu@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 13 | 4 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 1.52 | 2025-07-30 | 21 | 23 | head and neck squamous cell carcinoma; cancer-associated fibroblast; DNA microarray; collagen | Cancer-associated fibroblast; Collagen; DNA microarray; Head and neck squamous cell carcinoma | gelatinase A; gelatinase B; matrigel; matrix metalloproteinase 14; messenger RNA; animal experiment; animal model; animal tissue; Article; cancer associated fibroblast; cancer cell; cancer growth; carcinogenesis; carcinogenicity; COL3A1 gene; COL6A6 gene; controlled study; DNA microarray; extracellular matrix; FaDu cell line; female; fibroblast culture; gene; gene expression; head and neck squamous cell carcinoma; human; human cell; human tissue; mouse; mouth mucosa; nonhuman; overall survival; tumor invasion; tumor promotion | English | 2021 | 2021-02 | 10.3390/cancers13040654 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Characterization of Novel Progression Factors in Castration-Resistant Prostate Cancer Based on Global Comparative Proteome Analysis | Simple Summary Here, we investigated prostate cancer (PCa) tissues at each stage of progression, from benign prostatic hyperplasia to castration-resistant prostate cancer (CRPC), based on quantitative proteomic technology, including tissues after androgen deprivation therapy (ADT). In total, we identified 4768 proteins, and 4069 of them were quantified. We performed a systematic bioinformatics analysis of 865 differentially expressed proteins (DEPs) in the combined PCa tissues. We found 15 DEPs, including FOXA1 and HMGN1-3, as novel factors were significantly involved in the progression to CRPC after ADT in T3G3. All targets were verified to have increased levels of FOXA1 and HMGN1-3 in CRPC by immunoblotting and indirect enzyme-linked immunosorbent assay. The FOXA1 and HMGN1-3 proteins could be used as CRPC-related factors in clinical therapeutic agents. Identifying the biological change from hormone-naive prostate cancer to castration-resistant prostate cancer (CRPC) is a major clinical challenge for developing therapeutic agents. Although the pathways that lead to CRPC are not fully completely understood, recent evidence demonstrates that androgen signaling is often maintained through varied mechanisms. Androgen deprivation therapy (ADT) is used as a primary treatment for preventing the progression of prostate cancer (PCa). Here we investigated PCa tissues at each stage of progression, from benign prostatic hyperplasia (BPH) to CRPC, based on quantitative proteomic technology, including tissues after ADT. In total, 4768 proteins were identified in this study, of which 4069 were quantified in the combined PCa tissues. Among the quantified proteins, 865 were differentially expressed proteins (21.2%). Based on the quantitative protein results, we performed systematic bioinformatics analysis and found that the levels of 15 proteins, including FOXA1 and HMGN1-3, increased among T3G3, T3GX, and CRPC, despite the ADT. Among all targets, we verified the increased levels of FOXA1 and HMGN1-3 in CRPC by immunoblotting and indirect enzyme-linked immunosorbent assay. In summary, we discuss the changes in intracellular factors involved in the progression of CRPC PCa despite ADT. Moreover, we suggest that FOXA1 and HMGN1-3 proteins could be used as potential CRPC-related factors in clinical therapeutic agents. | Na, Ann-Yae; Choi, Soyoung; Yang, Eunju; Liu, Kwang-Hyeon; Kim, Sunghwan; Jung, Hyun Jin; Choe, Youngshik; Ha, Yun-Sok; Kwon, Tae Gyun; Lee, Jun Nyung; Lee, Sangkyu | Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Mass Spectrometry Convergence Res Ctr, Daegu 41566, South Korea; Green Nano Mat Res Ctr, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Korea Brain Res Inst, Daegu 41068, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu 41405, South Korea; Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu 41405, South Korea | ; Kim, Sunghwan/HKN-9812-2023 | 57201530058; 57202918688; 57191204368; 55768214700; 57203772967; 57212592926; 22833254300; 35487226400; 15073765400; 16301364600; 57209046767 | cpblady@hanmail.net;sylvdh@knu.ac.kr;ejy125@gmail.com;dstlkh@knu.ac.kr;sunghwank@knu.ac.kr;junghj@kbri.re.kr;dallarae@gmail.com;yunsokha@gmail.com;tgkwon@knu.ac.kr;ljnlover@gmail.com;sangkyu@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 13 | 14 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 0.28 | 2025-07-30 | 3 | 4 | prostate cancer; androgen deprivation therapy; comparative proteomics; castration-resistant prostate cancer; FOXA1; HMGN | ANDROGEN RECEPTOR; EXPRESSION; MECHANISMS; IDENTIFICATION; METASTASIS; MARKERS; CELLS; FOXA1 | Androgen deprivation therapy; Castration-resistant prostate cancer; Comparative proteomics; FOXA1; HMGN; Prostate cancer | hepatocyte nuclear factor 3alpha; high mobility group N1 protein; high mobility group N2 protein; high mobility group N3 protein; high mobility group protein; proteome; unclassified drug; androgen deprivation therapy; Article; bioinformatics; cancer growth; cancer staging; cancer tissue; castration resistant prostate cancer; comparative proteomics; controlled study; human; human tissue; immunoblotting; indirect ELISA; major clinical study; male; prostate hypertrophy; protein expression; protein expression level; protein fingerprinting; quantitative analysis | English | 2021 | 2021-07 | 10.3390/cancers13143432 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Cisplatin Resistance in Epstein-Barr-Virus-Associated Gastric Carcinoma Acquired through ATM Methylation | Simple Summary Gastric cancer (GC) is the fifth-leading type of cancer and the third -leading cause of death from cancer. Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is recently accountable for 10% of all the GC worldwide. Platinum drugs such as cisplatin and oxaliplatin are the first-line choice in GC chemotherapy. The widespread use of cisplatin leads to make tumor cells develop single or multiple drug resistance via various mechanisms. DNA hypermethylation on tumor suppressor genes is one of causes leading to drug resistances. 5-Azacytidine (5-AZA) is a chemical analogue of cytidine and inhibits DNA methyltransferase, resulting in DNA hypomethylation. Our main objective was to identify synergistic effect of two important GC drugs whose mechanisms may be in complementary cooperation. We found that cisplatin enhances its anticancer activity with 5-AZA through DNA demethylation in EBVaGC. Identifying this synergistic effect of two important GC drugs can be useful to treat EBVaGC which shows resistance to platinum-based chemotherapy. Epstein-Barr-virus-associated gastric carcinoma (EBVaGC), first reported in 1992, currently accounts for 10% of all gastric carcinoma worldwide. EBVaGC has unique DNA hypermethylation phenotypes that allow for higher proportions of DNA methylation than any other gastric cancer. CpG islands in the gene promoter region are one of the major regions in which DNA methylation controls gene transcription. Despite cisplatin-based chemotherapy being one of the standard treatment regimens for advanced gastric cancer, including EBVaGC, cisplatin alone or in combination with 5-fluorouracil has been limited by its less potent anticancer activity and the occurrence of cisplatin resistance. Accordingly, the current study evaluated the anticancer activities of a combination of cisplatin and 5-Azacytidine (5-AZA) against EBVaGC. Our findings showed that cisplatin upregulated the DNMT3A gene, whereas shRNA-targeted removal of DNMT3A mRNA contributed to cisplatin-mediated EBV lytic reactivation. Moreover, the removal of DNMT3A mRNA upregulated the ATM gene through DNA demethylation on the ATM promoter. Furthermore, CRISPR/Cas9-targeted removal of the ATM gene resulted in significantly reduced cell susceptibility and EBV lytic reactivation by a combination of cisplatin and DNMT3A inhibitor 5-AZA. Finally, 5-AZA exhibited a synergistic effect with cisplatin in anti-EBV and anti-EBVaGC activities by increasing drug susceptibility and EBV lytic reactivation. The aforementioned results suggest that cisplatin combined with DNA methylation inhibitors could be a novel therapeutic approach for EBVaGC. | Lee, Sun Hee; Choi, Su Jin; Choi, Wonhyeok; Cho, Subin; Cho, Miyeon; Kim, Dong Sun; Kang, Byung Woog; Kim, Jong Gwang; Lee, You Mie; Cho, Hyosun; Kang, Hyojeung | Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr, VOICE MRC,Canc Res Inst, Daegu 41566, South Korea; Duksung Womens Univ, Coll Pharm, Duksung Innovat Drug Ctr, Seoul 01369, South Korea; Kyungpook Natl Univ, Sch Med, Dept Anat, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Oncol Hematol, Canc Res Inst,Sch Med, Daegu 41405, South Korea; Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr, VOICE MRC,Dept Mol Pathophysiol, Daegu 41566, South Korea | Lee, Kyung-Soo/C-9016-2011; Kim, Dae/AAJ-7518-2021 | 58607352900; 57195296302; 57235777600; 57221713516; 57190213901; 57125070500; 28567838500; 59501049300; 8230508600; 55572361200; 8979751700 | ihappy278@nate.com;sujinchoi88@naver.com;dnjsgur8367@naver.com;tnqls5019@naver.com;cmy1004g@naver.com;doskim@knu.ac.kr;bwkang@knu.ac.kr;jkk21c@knu.ac.kr;lym@knu.ac.kr;hyosun1102@duksung.ac.kr;hkang72@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 13 | 17 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 0.14 | 2025-07-30 | 6 | 6 | cisplatin; 5-Azacytidine; DNA methylation; Epstein-Barr virus; DNMT3A; ATM | DNA METHYLATION; CANCER; 5-AZACYTIDINE; CHEMOTHERAPY; APOPTOSIS; PATTERNS; LEUKEMIA; AML | 5-Azacytidine; ATM; Cisplatin; DNA methylation; DNMT3A; epstein–Barr virus | antibiotic agent; antifungal agent; azacitidine; benzylsulfonyl fluoride; cholecystokinin octapeptide; cisplatin; diaminobenzidine; eosin; hematoxylin; hygromycin; paraffin; paraformaldehyde; animal experiment; animal model; animal tissue; antineoplastic activity; Article; body weight; cell suspension; cell viability; chemotherapy; controlled study; cytotoxicity; DNA extraction; DNA methylation; drug sensitivity; enzyme linked immunosorbent assay; Epstein Barr virus; female; fetal bovine serum; gastric carcinoma cell line; genetic transfection; immunohistochemistry; Lentivirus; luciferase assay; methylation; microscopy; mouse; nonhuman; phenotype; real time polymerase chain reaction; stomach cancer; stomach carcinoma; Western blotting | English | 2021 | 2021-09 | 10.3390/cancers13174252 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparison of Oncologic Outcomes between Transduodenal Ampullectomy and Pancreatoduodenectomy in Ampulla of Vater Cancer: Korean Multicenter Study | Simple Summary This study used multicenter data to compare the oncological safety of transduodenal ampullectomy (TDA) with that of pylorus-preserving pancreatoduodenectomy (PPPD) in early ampulla of Vater (AoV) cancer. Data for patients who underwent surgical resection for AoV cancer (pTis-T2 stage) from 2000 to 2019 were collected from 15 institutions. A total of 486 patients were enrolled (PPPD, 418; TDA, 68). The oncologic behavior (tumor size, T stage, differentiation, lymphovascular invasion) in the PPPD group was more aggressive than that in the TDA group at all T stages. The 5-year disease-free survival and overall survival did not differ between the two groups when considering all T stages or only the Tis + T1 group. In T1 patients, PPPD had survival outcomes superior to those in the TDA group. In the TDA group, lymph node dissection did not affect survival. In conclusion, PPPD should be the standard procedure for early AoV cancer. This study used multicenter data to compare the oncological safety of transduodenal ampullectomy (TDA) with that of pylorus-preserving pancreatoduodenectomy (PPPD) in early ampulla of Vater (AoV) cancer. Data for patients who underwent surgical resection for AoV cancer (pTis-T2 stage) from January 2000 to September 2019 were collected from 15 institutions. The clinicopathologic characteristics and survival outcomes were compared between the PPPD and TDA groups. A total of 486 patients were enrolled (PPPD, 418; TDA, 68). The oncologic behavior in the PPPD group was more aggressive than that in the TDA group at all T stages: larger tumor size (p = 0.034), advanced T stage (p < 0.001), aggressive cell differentiation (p < 0.001), and more lymphovascular invasion (p = 0.002). Five-year disease-free survival (DFS) and overall survival (OS) did not differ between the two groups when considering all T stages or only the Tis+T1 group. Among T1 patients, PPPD produced significantly better DFS (PPPD vs. TDA, 84.8% vs. 66.6%, p = 0.040) and superior OS (PPPD vs. TDA, 89.1% vs. 68.0%, p = 0.056) than TDA. Lymph node dissection (LND) in the TDA group did not affect DFS or OS (TDA + LND vs. TDA-only, DFS, p = 0.784; OS, p = 0.870). In conclusion, PPPD should be the standard procedure for early AoV cancer. | Hong, Seung-Soo; Han, Sung-Sik; Kwon, Wooil; Jang, Jin-Young; Kim, Hee-Joon; Cho, Chol-Kyoon; Ahn, Keun-Soo; Yang, Jae-Do; Park, Youngmok; Min, Seog-Ki; Moon, Ju-Ik; Roh, Young-Hoon; Lee, Seung-Eun; Park, Joon-Seong; Kim, Sang-Geol; Jeong, Chi-Young; Heo, Jin-Seok; Hwang, Ho-Kyoung | Yonsei Univ, Dept Hepatobiliary & Pancreat Surg, Coll Med, Seoul 03722, South Korea; Natl Canc Ctr, Dept Surg, Goyang 10408, South Korea; Seoul Natl Univ, Dept Surg, Coll Med, Seoul 03080, South Korea; Chonnam Natl Univ, Dept Surg, Sch Med, Gwangju 61469, South Korea; Keimyung Univ, Dongsan Hosp, Dept Surg, Sch Med, Daegu 42601, South Korea; Chonbuk Natl Univ, Dept Surg, Coll Med, Jeonju 54907, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Div HBP Surg, Dept Surg, Busan 49241, South Korea; Ewha Womans Univ, Dept Surg, Coll Med, Seoul 07985, South Korea; Konyang Univ Hosp, Dept Surg, Deajeon 35365, South Korea; Dong A Univ, Dept Surg, Coll Med, Busan 49201, South Korea; Chung Ang Univ, Chung Ang Univ Hosp, Dept Surg, Coll Med, Seoul 06973, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Surg, Coll Med, Seoul 06273, South Korea; Kyungpook Natl Univ, Dept Surg, Coll Med, Daegu 41944, South Korea; Gyeongsang Natl Univ, Dept Surg, Sch Med, Jinju 52727, South Korea; Sungkyunkwan Univ, Div Hepatobiliary Pancreat Surg, Dept Surg, Sch Med,Samsung Med Ctr, 81 Ilwon Dong, Seoul 06351, South Korea | ; Kim, Kyung/I-5501-2015; Park, Youngmok/AAV-9310-2021 | 57241350600; 55740202300; 35211119200; 7402965187; 55650398000; 7403100273; 59712504100; 41562471000; 55494378600; 8938656500; 25824384400; 56812523400; 35210819100; 57226672001; 21735842600; 8933394000; 7102832040; 23667358400 | hongss@yuhs.ac;sshan@ncc.re.kr;willdoc@snu.ac.kr;jangjy4@snu.ac.kr;heejoonkim@jnu.ac.kr;ckcho@jnu.ac.kr;ahnks@dsmc.or.kr;hirojawa@jbnu.ac.kr;pym777@pnuh.co.kr;mp9666@ewha.ac.kr;monjuik@kyuh.ac.kr;gsryh@dau.ac.kr;selee508@cau.ac.kr;JSPARK330@yuhs.ac;ksg@knu.ac.kr;drjcy@gnu.ac.kr;jinseok.heo@samsung.com;drhhk@yuhs.ac; | CANCERS | CANCERS | 2072-6694 | 13 | 9 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 0.34 | 2025-07-30 | 5 | 5 | ampulla of Vater cancer; transduodenal ampullectomy; pancreaticoduodenectomy | CLINICOPATHOLOGICAL ANALYSIS; RESECTION; CARCINOMA; SURVIVAL | Ampulla of Vater cancer; Pancreaticoduodenectomy; Transduodenal ampullectomy | adult; Article; cancer prognosis; cancer staging; clinical effectiveness; clinical feature; cohort analysis; disease free survival; female; human; intestine surgery; Korean (people); major clinical study; male; middle aged; multicenter study; overall survival; pancreaticoduodenectomy; patient safety; recurrence risk; retrospective study; risk factor; survival rate; transduodenal ampullectomy; treatment outcome; trend study; tumor invasion; tumor volume; Vater papilla carcinoma | English | 2021 | 2021-05 | 10.3390/cancers13092038 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Deep Learning Analysis of CT Images Reveals High-Grade Pathological Features to Predict Survival in Lung Adenocarcinoma | Simple Summary The high-grade pattern (micropapillary or solid pattern, MPSol) in lung adenocarcinoma affects the patient's poor prognosis. We aimed to develop a deep learning (DL) model for predicting any high-grade patterns in lung adenocarcinoma and to assess the prognostic performance of model in advanced lung cancer patients who underwent neoadjuvant of definitive concurrent chemoradiation therapy (CCRT). Our model considering both tumor and peri-tumoral area showed area under the curve value of 0.8. DL model worked well in independent validation set of advanced lung cancer, stratifying their survival significantly. The subgroup with a high probability of MPSol estimated by the DL model showed a 1.76-fold higher risk of death. Thus, our DL model can be useful in estimating high-grade histologic patterns in lung adenocarcinomas and predicting clinical outcomes of patients with advanced lung cancer who underwent neoadjuvant or definitive CCRT. We aimed to develop a deep learning (DL) model for predicting high-grade patterns in lung adenocarcinomas (ADC) and to assess the prognostic performance of model in advanced lung cancer patients who underwent neoadjuvant or definitive concurrent chemoradiation therapy (CCRT). We included 275 patients with 290 early lung ADCs from an ongoing prospective clinical trial in the training dataset, which we split into internal-training and internal-validation datasets. We constructed a diagnostic DL model of high-grade patterns of lung ADC considering both morphologic view of the tumor and context view of the area surrounding the tumor (MC3DN; morphologic-view context-view 3D network). Validation was performed on an independent dataset of 417 patients with advanced non-small cell lung cancer who underwent neoadjuvant or definitive CCRT. The area under the curve value of the DL model was 0.8 for the prediction of high-grade histologic patterns such as micropapillary and solid patterns (MPSol). When our model was applied to the validation set, a high probability of MPSol was associated with worse overall survival (probability of MPSol >0.5 vs. <0.5; 5-year OS rate 56.1% vs. 70.7%), indicating that our model could predict the clinical outcomes of advanced lung cancer patients. The subgroup with a high probability of MPSol estimated by the DL model showed a 1.76-fold higher risk of death (HR 1.76, 95% CI 1.16-2.68). Our DL model can be useful in estimating high-grade histologic patterns in lung ADCs and predicting clinical outcomes of patients with advanced lung cancer who underwent neoadjuvant or definitive CCRT. | Choi, Yeonu; Aum, Jaehong; Lee, Se-Hoon; Kim, Hong-Kwan; Kim, Jhingook; Shin, Seunghwan; Jeong, Ji Yun; Ock, Chan-Young; Lee, Ho Yun | Sungkyunkwan Univ, Samsung Med Ctr, Dept Radiol, Sch Med SKKU SOM, Seoul 06351, South Korea; Lunit Inc, Seoul 06241, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Hematooncol,Sch Med SKKU SOM, Seoul 06351, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Thorac Surg, Sch Med SKKU SOM, Seoul 06351, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Pathol, Sch Med, Daegu 41404, South Korea | ; Lee, Soohyeon/AAX-9843-2020; Lee, Ho Yun/D-6086-2012; Kim, Hong/AAR-4892-2020 | 56610984900; 57208029787; 58376934900; 34968151200; 7601380132; 56504330800; 57205472984; 36667082500; 57192502540 | skyblue718@skku.edu;brian.j.aum@lunit.io;shlee119@skku.edu;hkts@skku.edu;jkimsmc@skku.edu;ssh@lunit.io;jyjeong@knu.ac.kr;ock.chanyoung@lunit.io;hoyunlee@skku.edu; | CANCERS | CANCERS | 2072-6694 | 13 | 16 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 0.83 | 2025-07-30 | 16 | 19 | lung adenocarcinoma (ADC); heterogeneity; high-grade pattern; histology; prognosis; recurrence | RESPIRATORY SOCIETY CLASSIFICATION; INTERNATIONAL-ASSOCIATION; CANCER; PATTERN; SYSTEM | Heterogeneity; High-grade pattern; Histology; Lung adenocarcinoma (ADC); Prognosis; Recurrence | adult; advanced cancer; aged; Article; cancer free survival; cancer prognosis; cancer staging; chemoradiotherapy; clinical outcome; computer assisted tomography; controlled study; deep learning; female; follow up; histopathology; human; lung adenocarcinoma; major clinical study; male; middle aged; mortality risk; neoadjuvant chemotherapy; overall survival; progression free survival; prospective study; retrospective study; survival prediction; tumor recurrence | English | 2021 | 2021-08 | 10.3390/cancers13164077 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Definitive Chemoradiotherapy versus Radical Hysterectomy Followed by Tailored Adjuvant Therapy in Women with Early-Stage Cervical Cancer Presenting with Pelvic Lymph Node Metastasis on Pretreatment Evaluation: A Propensity Score Matching Analysis | Simple Summary Pelvic nodal involvement is frequently present in early-stage cervical cancer patients on pretreatment imaging studies. However, it is unclear whether radical chemoradiotherapy (CRT) or radical hysterectomy RH followed by tailored adjuvant radiotherapy is more appropriate in these patients. We compared oncological outcomes of up-front surgery followed by tailored adjuvant radiotherapy and definitive CRT in these patients. We found no differences in outcomes existed between definitive CRT and hysterectomy with tailored adjuvant radiotherapy. However, after surgery, 88.7% of patients required adjuvant radiotherapy. These findings suggest that definitive CRT can avoid unplanned tri-modality therapy without compromising oncologic outcomes. To compare the oncologic outcomes between chemoradiotherapy (CRT) and radical hysterectomy followed by tailored adjuvant therapy in patients with early cervical cancer presenting with pelvic lymph node metastasis. We retrospectively analyzed the medical records of women with early cervical cancer presenting with positive pelvic nodes identified on pretreatment imaging assessment. Propensity score matching was employed to control for the heterogeneity between two groups according to confounding factors. Overall survival, disease-free survival, and pattern of failure were compared between the two groups. A total of 262 patients were identified; among them, 67 received definitive CRT (group A), and 195 received hysterectomy (group B). Adjuvant therapy was administered to 88.7% of group B. There were no significant differences between group A and group B regarding the 5-year overall survival rates (89.2% vs. 89.0%) as well as disease-free survival rates (80.6% vs. 82.7%), and patterns of failure. Distant metastasis was the major failure pattern identified in both groups. In multivariate analysis, non-squamous histology was significantly associated with poorer overall survival. As there are no significant differences in 5-year OS, DFS, and patterns of failure, definitive CRT could avoid the combined modality therapy without compromising oncologic outcomes. | Park, Jongmoo; Kim, Yeon-Joo; Song, Mi-Kyung; Nam, Joo-Hyun; Park, Sang-Yoon; Kim, Young-Seok; Kim, Joo-Young | Kyungpook Natl Univ, Dept Radiat Oncol, Chilgok Hosp, Daegu 41404, South Korea; Natl Canc Ctr, Proton Therapy Ctr, Dept Radiat Oncol, Goyang Si 10408, Gyeonggi Do, South Korea; Natl Canc Ctr, Biometr Res Branch, Goyang Si 10408, Gyeonggi Do, South Korea; Natl Canc Ctr, Biostat Collaborat Unit, Goyang Si 10408, Gyeonggi Do, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Obstet & Gynecol, 88,Olympic Ro 43 Gil, Seoul 05505, South Korea; Natl Canc Ctr, Ctr Uterine Canc, Goyang Si 10408, Gyeonggi Do, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Radiat Oncol, 88 Olympic Ro 43 Gil, Seoul 05505, South Korea | Kim, Yangdo/AAC-2495-2021; Kim, Hyung/J-5451-2012; Kim, Ju/AAV-3029-2020 | 56180048900; 57216357970; 56221929800; 23486473800; 56515542200; 57040026600; 57207436986 | fauny11@naver.com;yjkim1785@ncc.re.kr;songmk@nhis.or.kr;jhnam@amc.seoul.kr;parksang@ncc.re.kr;ysk@amc.seoul.kr;jooyoungcasa@ncc.re.kr; | CANCERS | CANCERS | 2072-6694 | 13 | 15 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 0.69 | 2025-07-30 | 15 | 14 | uterine cervical cancer; radiotherapy; chemotherapy; hysterectomy | PROGNOSTIC-FACTORS; ONCOLOGY-GROUP; RADIOTHERAPY; SURGERY; MRI; BRACHYTHERAPY; CHEMOTHERAPY; IIA; PATTERNS; BIOPSY | Chemotherapy; Hysterectomy; Radiotherapy; Uterine cervical cancer | adjuvant chemoradiotherapy; adjuvant radiotherapy; adult; aged; Article; brachytherapy; cancer adjuvant therapy; cancer staging; cohort analysis; controlled study; diagnostic imaging; disease free survival; distant metastasis; female; health care policy; human; intermethod comparison; lymph node metastasis; major clinical study; medical record; middle aged; multimodality cancer therapy; overall survival; patient identification; patient preference; propensity score; radical hysterectomy; retrospective study; treatment outcome; uterine cervix cancer; very elderly | English | 2021 | 2021-08 | 10.3390/cancers13153703 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Draft Genome of the Edible Oriental Insect Protaetia brevitarsis seulensis | Lee, Joon Ha; Jung, Myunghee; Shin, Younhee; Subramaniyam, Sathiyamoorthy; Kim, In-Woo; Seo, Minchul; Kim, Mi-Ae; Kim, Seong Hyun; Hwang, Jihye; Choi, Eun Hwa; Hwang, Ui Wook; Hwang, Jae Sam | Rural Dev Adm, Natl Inst Agr Sci, Dept Agr Biol, Wonju, South Korea; Insilicogen Inc, Res & Dev Ctr, Yongin, South Korea; Kyungpook Natl Univ, Dept Biol Educ, Teachers Coll, Daegu, South Korea; Kyungpook Natl Univ, Inst Phylogen & Evolut, Daegu, South Korea | Kim, Juhee/KFS-3069-2024; Choi, Eun Hwa/HTN-1610-2023 | 37960965000; 56072068700; 56420396400; 42762340400; 55477735200; 36182504700; 56911258300; 56494313500; 57219609298; 57203556599; 35074015800; 16637012100 | hwangjs@korea.kr; | FRONTIERS IN GENETICS | FRONT GENET | 1664-8021 | 11 | SCIE | GENETICS & HEREDITY | 2021 | 4.772 | 24.3 | 0.45 | 2025-07-30 | 2 | 4 | Cetoniinae; Kolbe; genome; Protaetia brevitarsis seulensis; edible insect | GENE; ANNOTATION; LARVAE | Cetoniinae; edible insect; genome; Kolbe; Protaetia brevitarsis seulensis | buffer; carbohydrate; citrate sodium; citric acid; cytochrome; genomic DNA; liquid nitrogen; phosphate buffered saline; reagent; transcriptome; trizol; centrifugation; DNA extraction; fatty acid metabolism; food industry; gel electrophoresis; gene expression; gene ontology; gene structure; genetic analysis; genome size; haplotype; humidity; illumina sequencing; insect; larva; microbial contamination; phylogenetic tree; protaetia brevitaris seulensis; RNA sequencing; sawdust; volatilization; whole genome sequencing | English | 2021 | 2021-01-13 | 10.3389/fgene.2020.593994 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Enhancement of Biomass Production in Colony-Forming Green Algae, Botryosphaerella sudetica, Under Mixotrophic Cultivation | In this study, we characterized the potential of colony-forming green algae, Botryosphaerella sudetica KNUA107, isolated from Ulleung Island, South Korea, as a bioresource and analyzed the effects of mixotrophic cultivation on its bioresource production efficiency. Internal transcribed spacer (ITS) (ITS1, 5.8S, and ITS2), ribulose bisphosphate carboxylase large subunit (rbcL), and elongation factor Tu (tufa) regions were used for molecular identification and phylogenetic analysis. B. sudetica KNUA107 had a strong relationship with the green algae of Botryococcus and Botryosphaerella genera, which are colony-forming species, and was also associated with members of the Neochloris genus. To improve biomass productivity, we tested mixotrophic cultivation conditions using several organic carbon sources. Glucose supplementation stimulated B. sudetica KNUA107 growth and reduced the time needed to reach the stationary phase. In addition, the colony size was 1.5-2.0 times larger with glucose than in photoautotrophic cultures, and settleability improved in proportion to colony size. The total lipid content and biomass productivity were also higher in cultures supplemented with glucose. Among the lipid components, saturated fatty acids and monounsaturated fatty acids had the highest proportion. Our study suggests that B. sudetica KNUA107, which has enhanced efficiency in biomass production and lipid components under mixotrophic cultivation, has high potential as a bioresource. | Yun, Hyun-Sik; Kim, Young-Saeng; Yoon, Ho-Sung | Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Ulleung Do & Dok Do, Daegu, South Korea | 57215320824; 35798433500; 7402990205 | kyslhh1228@hanmail.net;hsy@knu.ac.kr; | FRONTIERS IN GENETICS | FRONT GENET | 1664-8021 | 12 | SCIE | GENETICS & HEREDITY | 2021 | 4.772 | 24.3 | 0.15 | 2025-07-30 | 3 | 3 | colony-forming; green algae; mixotrophic cultivation; glucose; settleability; saturated fatty acid; monounsaturated fatty acid | CHLAMYDOMONAS-REINHARDTII; BIODIESEL PRODUCTION; NUTRIENT REMOVAL; MICROALGAE; GROWTH; LIGHT; OIL; CHLOROPHYCEAE; SETTLEABILITY; ACCUMULATION | colony-forming; glucose; green algae; mixotrophic cultivation; monounsaturated fatty acid; saturated fatty acid; settleability | carotenoid; chlorophyll; elongation factor Tu; fructose; galactose; glucose; internal transcribed spacer; internal transcribed spacer 1; internal transcribed spacer 2; monounsaturated fatty acid; pigment; ribose; ribulosebisphosphate carboxylase; saturated fatty acid; sucrose; Article; biomass production; Botryococcus; Botryosphaerella sudetica KNUA107 strain; colony formation; green alga; mixotroph; photoautotroph; phylogeny | English | 2021 | 2021-06-04 | 10.3389/fgene.2021.669702 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | High-Fat Diet-Induced Obese Effects of Adipocyte-Specific CXCR2 Conditional Knockout in the Peritoneal Tumor Microenvironment of Ovarian Cancer | Obesity contributes to one-fifth of cancer deaths. Ovarian cancer (OC) progression is frequently asymptomatic, making its early detection difficult and its chance of survival low. OC expresses highly tumorigenic chemokines, CXCL1/8, of which the specific receptor CXCR2 is increased in the adipocytes. So, the CXCL1/8-CXCR2 axis may appear as a molecular link between obesity and OC. Here, we generated adipocyte-specific CXCR2 conditional knockout (cKO) mice to investigate how this CXCR2 cKO affects the peritoneal dissemination of OC under obese conditions. High-fat, diet-induced obese mice had a shorter survival than lean mice. Particularly, obese cKO mice had a reduced tumor burden but increased ascites accumulation, showing a decreased floating tumor burden in ascites, as well as proliferation and macrophage infiltration in tumors compared to obese wild-type mice. Despite the ascites accumulation, adipocyte-specific CXCR2 cKO reduced the obesity-induced tumor burden, likely altering the peritoneal tumor microenvironment of OC. Obesity contributes to ovarian cancer (OC) progression via tumorigenic chemokines. Adipocytes and OC cells highly express CXCR2, and its ligands CXCL1/8, respectively, indicating that the CXCL1/8-CXCR2 axis is a molecular link between obesity and OC. Here, we investigated how the adipocyte-specific CXCR2 conditional knockout (cKO) affected the peritoneal tumor microenvironment of OC in a high-fat diet (HFD)-induced obese mouse model. We first generated adipocyte-specific CXCR2 cKO in mice: adipose tissues were not different in crown-like structures and adipocyte size between the wild-type (WT) and cKO mice but expressed lower levels of CCL2/6 compared to the obese WT mice. HFD-induced obese mice had a shorter survival time than lean mice. Particularly, obese WT and cKO mice developed higher tumors and ascites burdens, respectively. The ascites from the obese cKO mice showed increased vacuole clumps but decreased the floating tumor burden, tumor-attached macrophages, triglyceride, free fatty acid, CCL2, and TNF levels compared to obese WT mice. A tumor analysis revealed that obese cKO mice attenuated inflammatory areas, PCNA, and F4/80 compared to obese WT mice, indicating a reduced tumor burden, and there were positive relationships between the ascites and tumor parameters. Taken together, the adipocyte-specific CXCR2 cKO was associated with obesity-induced ascites despite a reduced tumor burden, likely altering the peritoneal tumor microenvironment of OC. | Choe, Deokyeong; Lee, Eun-Sook; Beeghly-Fadiel, Alicia; Wilson, Andrew J.; Whalen, Margaret M.; Adunyah, Samuel E.; Son, Deok-Soo | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Florida A&M Univ, Coll Pharm, Dept Pharmaceut Sci, Tallahassee, FL 32301 USA; Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN 37203 USA; Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Nashville, TN 37203 USA; Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, Nashville, TN 37232 USA; Tennessee State Univ, Dept Chem, Nashville, TN 37209 USA; Meharry Med Coll, Dept Biochem Canc Biol Neurosci & Pharmacol, Sch Med, Nashville, TN 37208 USA | Choe, Deokyeong/AAQ-1194-2020; Wilson, Andrew/KRQ-9512-2024 | 37074453400; 55874892600; 57216794151; 35406866600; 7007052474; 6701347337; 56036704600 | cd02da@knu.ac.kr;eunsook.lee@famu.edu;alicia.beeghly@vumc.org;andrew.j.wilson@vumc.org;mwhalen@tnstate.edu;sadunyah@mmc.edu;dson@mmc.edu; | CANCERS | CANCERS | 2072-6694 | 13 | 19 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 0.34 | 2025-07-30 | 5 | 5 | obesity; high-fat diet; CXCR2; ascites; ovarian cancer | NF-KAPPA-B; CHEMOKINE; GROWTH; SURVIVAL; CELLS; CCL2; INFLAMMATION; EXPRESSION; MOUSE | Ascites; CXCR2; High-fat diet; Obesity; Ovarian cancer | chemokine receptor CXCR2; CXCL1 chemokine; CXCL2 chemokine; epithelial derived neutrophil activating factor 78; gamma interferon inducible protein 10; monocyte chemotactic protein 1; adipocyte; adipose tissue; animal cell; animal experiment; animal model; animal tissue; Article; ascites; cancer growth; cell vacuole; controlled study; diet-induced obesity; disease burden; female; histopathology; immunohistochemistry; lean body weight; mouse; nonhuman; oncological parameters; ovary cancer; peritoneum tumor; proteomics; radioimmunoprecipitation; survival time; tumor microenvironment; Western blotting | English | 2021 | 2021-10 | 10.3390/cancers13195033 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Liver Stiffness-Based Risk Prediction Model for Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease | Simple Summary A new liver stiffness (LS) based risk prediction model for the development of hepatocellular carcinoma (HCC) in patients with non-alcoholic fatty liver disease (NAFLD), which consists of old age, low platelet count, aspartate aminotransferase level, and high LS measured by transient elastography, showed acceptable performance in the internal and external validation in Asian patients. Non-alcoholic fatty liver disease (NAFLD) is associated with an increased hepatocellular carcinoma (HCC) risk. We established and validated a liver stiffness (LS)-based risk prediction model for HCC development in patients with NAFLD. A total of 2666 and 467 patients with NAFLD were recruited in the training and validation cohorts, respectively. NAFLD was defined as controlled attenuated parameter >= 238 dB/m by transient elastography. Over a median of 64.6 months, HCC developed in 22 (0.8%) subjects in the training cohort. Subjects who developed HCC were older and had higher prevalence of diabetes and cirrhosis, lower platelet count, and higher AST levels compared to those who did not develop HCC (all p = 60 years (hazard ratio (HR) = 9.1), platelet count = 9.3 kPa (HR = 13.8) were independent predictors (all p = 34 IU/L. AUCs for predicting HCC development at 2, 3, and 5 years were 0.948, 0.947, and 0.939, respectively. This model was validated in the validation cohort (AUC 0.777, 0.781, and 0.784 at 2, 3, and 5 years, respectively). The new risk prediction model for NAFLD-related HCC development showed acceptable performance in the training and validation cohorts. | Lee, Jae Seung; Sinn, Dong Hyun; Park, Soo Young; Shin, Hye Jung; Lee, Hye Won; Kim, Beom Kyung; Park, Jun Yong; Kim, Do Young; Ahn, Sang Hoon; Oh, Joo Hyun; Lee, Jung Il; Kim, Seung Up | Yonsei Univ, Dept Internal Med, Coll Med, Seoul 03722, South Korea; Yonsei Univ, Inst Gastroenterol, Coll Med, Seoul 03722, South Korea; Severance Hosp, Yonsei Liver Ctr, Seoul 03722, South Korea; Samsung Med Ctr, Dept Med, Seoul 06351, South Korea; Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Yonsei Univ, Dept Biomed Syst Informat, Biostat Collaborat Unit, Coll Med, Seoul 03722, South Korea; Nowon Eulji Med Ctr, Dept Med, Seoul 01830, South Korea; Gangnam Severance Hosp, Dept Internal Med, Seoul 06273, South Korea | Lee, Hye/D-9081-2016; Lee, Jeong-Hoon/Q-1055-2018; Kim, Sun/L-4239-2013; Ahn, Sang Hoon/AFM-2603-2022; Park, Jun/H-7127-2019; Kim, Nayoung/J-5387-2012; SANG-HOON, AHN/AAV-2600-2020; LEE, JAE SEUNG/KHT-9575-2024; Sinn, Dong/JAC-4247-2023; Kim, Yoon/G-6633-2015 | 57204060462; 23493891100; 57191674344; 57203549694; 57200110315; 35302925200; 47861376300; 56119929100; 7401989551; 57211991276; 57190744199; 54933821200 | sikarue@yuhs.ac;sinndhn@hanmail.net;psyoung0419@gmail.com;HJSHIN105@yuhs.ac;lorry-lee@yuhs.ac;beomkkim@yuhs.ac;drpjy@yuhs.ac;dyk1025@yuhs.ac;ahnsh@yuhs.ac;mdflorence@yuhs.ac;ksukorea@yuhs.ac; | CANCERS | CANCERS | 2072-6694 | 13 | 18 | SCIE | ONCOLOGY | 2021 | 6.575 | 24.3 | 1.31 | 2025-07-30 | 23 | 23 | hepatocellular carcinoma; non-alcoholic fatty liver disease; liver cirrhosis; liver fibrosis; transient elastography; liver stiffness; risk prediction | TRANSIENT ELASTOGRAPHY; JAPANESE PATIENTS; CANCER; EPIDEMIOLOGY; ASSOCIATION; PREVALENCE; BURDEN | Hepatocellular carcinoma; Liver cirrhosis; Liver fibrosis; Liver stiffness; Non-alcoholic fatty liver disease; Risk prediction; Transient elastography | alanine aminotransferase; albumin; aspartate aminotransferase; bilirubin; cholesterol; adult; aged; albumin blood level; Article; cancer incidence; cancer risk; carcinogenesis; cholesterol blood level; cohort analysis; controlled study; diabetes mellitus; disease association; female; follow up; groups by age; human; human cell; hypertension; liver cell carcinoma; liver cirrhosis; liver stiffness; liver stiffness based risk prediction model; major clinical study; male; middle aged; model; nonalcoholic fatty liver; platelet count; prediction; predictor variable; prevalence; retrospective study; transient elastography; validation study | English | 2021 | 2021-09 | 10.3390/cancers13184567 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | MONTI: A Multi-Omics Non-negative Tensor Decomposition Framework for Gene-Level Integrative Analysis | Multi-omics data is frequently measured to enrich the comprehension of biological mechanisms underlying certain phenotypes. However, due to the complex relations and high dimension of multi-omics data, it is difficult to associate omics features to certain biological traits of interest. For example, the clinically valuable breast cancer subtypes are well-defined at the molecular level, but are poorly classified using gene expression data. Here, we propose a multi-omics analysis method called MONTI (Multi-Omics Non-negative Tensor decomposition for Integrative analysis), which goal is to select multi-omics features that are able to represent trait specific characteristics. Here, we demonstrate the strength of multi-omics integrated analysis in terms of cancer subtyping. The multi-omics data are first integrated in a biologically meaningful manner to form a three dimensional tensor, which is then decomposed using a non-negative tensor decomposition method. From the result, MONTI selects highly informative subtype specific multi-omics features. MONTI was applied to three case studies of 597 breast cancer, 314 colon cancer, and 305 stomach cancer cohorts. For all the case studies, we found that the subtype classification accuracy significantly improved when utilizing all available multi-omics data. MONTI was able to detect subtype specific gene sets that showed to be strongly regulated by certain omics, from which correlation between omics types could be inferred. Furthermore, various clinical attributes of nine cancer types were analyzed using MONTI, which showed that some clinical attributes could be well explained using multi-omics data. We demonstrated that integrating multi-omics data in a gene centric manner improves detecting cancer subtype specific features and other clinical features, which may be used to further understand the molecular characteristics of interest. The software and data used in this study are available at: https://github.com/ inukj/MONTI. | Jung, Inuk; Kim, Minsu; Rhee, Sungmin; Lim, Sangsoo; Kim, Sun | Kyungpook Natl Univ, Dept Comp Sci & Engn, Daegu, South Korea; Oak Ridge Natl Lab, Comp & Computat Sci Directorate, Oak Ridge, TN 37830 USA; Seoul Natl Univ, Dept Comp Sci & Engn, Seoul, South Korea; Seoul Natl Univ, Interdisciplinary Program Bioinformat, Seoul, South Korea | Lim, Sangsoo/GXM-6835-2022 | 56067575500; 58926828100; 55236314400; 57191446217; 36063436900 | inukjung@knu.ac.kr;sunkim.bioinfo@snu.ac.kr; | FRONTIERS IN GENETICS | FRONT GENET | 1664-8021 | 12 | SCIE | GENETICS & HEREDITY | 2021 | 4.772 | 24.3 | 0.69 | 2025-07-30 | 7 | 10 | feature selection; tensor decomposition; cancer; multi-omics; integrative analysis | BREAST-CANCER; DNA METHYLATION; CLASSIFICATION; PROGNOSIS | cancer; feature selection; integrative analysis; multi-omics; tensor decomposition | microRNA; accuracy; Article; breast cancer; cluster analysis; colon cancer; decomposition; DNA methylation; gene expression; genetic algorithm; human; major clinical study; multi omics non negative tensor decomposition framework; multiomics; software; stomach cancer; tensor decomposition | English | 2021 | 2021-09-10 | 10.3389/fgene.2021.682841 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Correction | MONTI: A Multi-Omics Non-Negative Tensor Decomposition Framework for Gene-Level Integrative Analysis (vol 12, 682841, 2021) | Jung, Inuk; Kim, Minsu; Rhee, Sungmin; Lim, Sangsoo; Kim, Sun | Kyungpook Natl Univ, Dept Comp Sci & Engn, Daegu, South Korea; Oak Ridge Natl Lab, Comp & Computat Sci Directorate, Oak Ridge, TN 37830 USA; Seoul Natl Univ, Dept Comp Sci & Engn, Seoul, South Korea; Seoul Natl Univ, Interdisciplinary Program Bioinformat, Seoul, South Korea | Lim, Sangsoo/GXM-6835-2022 | 56067575500; 58926828100; 55236314400; 57191446217; 36063436900 | inukjung@knu.ac.kr;sunkim.bioinfo@snu.ac.kr; | FRONTIERS IN GENETICS | FRONT GENET | 1664-8021 | 12 | SCIE | GENETICS & HEREDITY | 2021 | 4.772 | 24.3 | 1.72 | 2025-07-30 | 0 | 3 | feature selection; tensor decomposition; cancer; multi-omics; integrative analysis | cancer; feature selection; integrative analysis; multi-omics; tensor decomposition | erratum | English | 2021 | 2021-10-25 | 10.3389/fgene.2021.778490 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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