연구성과로 돌아가기
2022 연구성과 (96 / 280)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | New Equivalent Circuit of a Cymbal Transducer Incorporating the Third Harmonic Mode of Vibration | A cymbal transducer is composed of a pair of metal caps and a piezoceramic disk. Cymbal transducers arranged in an array exhibit broadband characteristics. Although the finite element method has been widely used for analyzing the transducer and its array, an equivalent circuit that allows efficient analysis was recently developed. However, this previously reported circuit was based solely on the fundamental vibration mode of the transducer, and is thus unsuitable for analyzing the broadband characteristics of the cymbal array. Therefore, to overcome this limitation, a new broadband equivalent circuit for the cymbal transducer was devised in the present study. The new circuit was constructed by incorporating terms related to the 3(rd) harmonic vibration mode of the cap and corresponding radiation impedance into the existing equivalent circuit. The validity of this novel circuit was verified by comparing the analysis results with those obtained from the measurement of acoustic characteristics exhibited by a cymbal-transducer specimen. Compared with the previous circuit, the new equivalent circuit allows more accurate analysis and design of a cymbal transducer over a wider frequency range. | Shim, Hayeong; Kim, Kyungseop; Seo, Heeseon; Roh, Yongrae | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Agcy Def Dev, Chang Won 51678, South Korea | 57202806954; 9634041100; 24765212200; 7102361870 | yryong@knu.ac.kr; | IEEE SENSORS JOURNAL | IEEE SENS J | 1530-437X | 1558-1748 | 22 | 16 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION;PHYSICS, APPLIED | 2022 | 4.3 | 23.0 | 0.45 | 2025-06-25 | 5 | 5 | Cymbal transducer; equivalent circuit; multi-mode; modal analysis; transmitting voltage response | ELECTROMECHANICAL TRANSDUCERS; REPRESENTATION; DESIGN | Cymbal transducer; Equivalent circuit; Modal analysis; Multi-mode; Transmitting voltage response | Acoustic impedance; Electric network analysis; Finite element method; Harmonic analysis; Modal analysis; Piezoelectric ceramics; Timing circuits; Transducers; Vibration analysis; Broadband characteristics; Broadband Communication; Cymbal transducer; Finite element analyse; Impedance; Multimodes; Third harmonic mode; Transmitting voltage response; Vibration; Vibration modes; Equivalent circuits | English | 2022 | 2022-08-15 | 10.1109/jsen.2022.3182799 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Nitric Oxide Signaling and Its Association with Ubiquitin-Mediated Proteasomal Degradation in Plants | Nitric oxide (NO) is a versatile signaling molecule with diverse roles in plant biology. The NO-mediated signaling mechanism includes post-translational modifications (PTMs) of target proteins. There exists a close link between NO-mediated PTMs and the proteasomal degradation of proteins via ubiquitylation. In some cases, ubiquitin-mediated proteasomal degradation of target proteins is followed by an NO-mediated post-translational modification on them, while in other cases NO-mediated PTMs can regulate the ubiquitylation of the components of ubiquitin-mediated proteasomal machinery for promoting their activity. Another pathway that links NO signaling with the ubiquitin-mediated degradation of proteins is the N-degron pathway. Overall, these mechanisms reflect an important mechanism of NO signal perception and transduction that reflect a close association of NO signaling with proteasomal degradation via ubiquitylation. Therefore, this review provides insight into those pathways that link NO-PTMs with ubiquitylation. | Pande, Anjali; Mun, Bong-Gyu; Khan, Murtaza; Rahim, Waqas; Lee, Da-Sol; Lee, Geun-Mo; Al Azawi, Tiba Nazar Ibrahim; Hussain, Adil; Yun, Byung-Wook | Kyungpook Natl Univ, Coll Agr & Life Sci, Lab Plant Mol Pathol & Funct Genom, Dept Plant Biosci,Sch Appl Biosci, Daegu 41944, South Korea; Abdul Wali Khan Univ, Dept Entomol, Lab Cell Biol, Mardan 23200, Khyber Pakhtunk, Pakistan | Mun, BongGyu/GYD-6010-2022; Hussain, Adil/K-6016-2018; Pande, Anjali/ABH-2333-2021; Hussain, Dr. Adil/K-6016-2018 | 57222624154; 57147241300; 57207990116; 57431774700; 57222624235; 57222627507; 57224980187; 41961162600; 8245123600 | anjali.pande23@gmail.com;mun0301@naver.com;murtazakhan.bio@gmail.com;waqasrahim999@yahoo.com;giftanna@naver.com;looxia@naver.com;redflower660@yahoo.com;adilhussain@awkum.edu.pk;bwyun@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 0.58 | 2025-06-25 | 16 | 17 | nitric oxide; ubiquitylation; S-nitrosylation; proteasome; proteolysis | END RULE PATHWAY; PROGRAMMED CELL-DEATH; TRANSCRIPTION COACTIVATOR NPR1; S-NITROSYLATED PROTEINS; ASCORBATE PEROXIDASE; REACTIVE OXYGEN; POSTTRANSLATIONAL MODIFICATION; FUNCTIONAL-CHARACTERIZATION; ARABIDOPSIS-THALIANA; HYDROGEN-PEROXIDE | Nitric oxide; Proteasome; Proteolysis; S‐nitrosylation; Ubiquitylation | Nitric Oxide; Plant Proteins; Plants; Proteasome Endopeptidase Complex; Proteolysis; Signal Transduction; Ubiquitin; Ubiquitination; influenza vaccine; jasmonic acid; nitric oxide; polyubiquitin; proteasome; reactive oxygen metabolite; superoxide dismutase; ubiquitin; nitric oxide; plant protein; ubiquitin; acclimatization; Arabidopsis thaliana; botany; controlled study; environmental stress; gene overexpression; germination; nitrosylation; nonhuman; plant immunity; protein degradation; protein processing; protein protein interaction; Review; S-nitrosylation; signal detection; signal transduction; stoichiometry; ubiquitination; genetics; metabolism; plant; signal transduction; ubiquitination | English | 2022 | 2022-02 | 10.3390/ijms23031657 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Correction | Nitric Oxide Signaling and Its Association with Ubiquitin-Mediated Proteasomal Degradation in Plants (vol 23, 1657, 2022) | Pande, Anjali; Mun, Bong-Gyu; Khan, Murtaza; Rahim, Waqas; Lee, Da-Sol; Lee, Geun-Mo; Al Azawi, Tiba Nazar Ibrahim; Hussain, Adil; Yun, Byung-Wook | Kyungpook Natl Univ, Sch Appl Biosci, Dept Plant Biosci, Coll Agr & Life Sci,Lab Plant Mol Pathol & Funct, Daegu 41944, South Korea; Abdul Wali Khan Univ, Dept Entomol, Cell Biol Lab, Mardan 23200, Khyber Pakhtunk, Pakistan | Hussain, Adil/K-6016-2018; Mun, BongGyu/GYD-6010-2022; Pande, Anjali/ABH-2333-2021; Hussain, Dr. Adil/K-6016-2018 | 57222624154; 57147241300; 57207990116; 57431774700; 57222624235; 57222627507; 57224980187; 41961162600; 8245123600 | anjali.pande23@gmail.com;mun0301@naver.com;murtazakhan.bio@gmail.com;waqasrahim999@yahoo.com;giftanna@naver.com;looxia@naver.com;redflower660@yahoo.com;adilhussain@awkum.edu.pk;bwyun@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 10 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 0 | 2025-06-25 | 0 | 0 | erratum | English | 2022 | 2022-05 | 10.3390/ijms23105628 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Novel Dormancy Mechanism of Castration Resistance in Bone Metastatic Prostate Cancer Organoids | Advanced prostate cancer (PCa) patients with bone metastases are treated with androgen pathway directed therapy (APDT). However, this treatment invariably fails and the cancer becomes castration resistant. To elucidate resistance mechanisms and to provide a more predictive pre-clinical research platform reflecting tumor heterogeneity, we established organoids from a patient-derived xenograft (PDX) model of bone metastatic prostate cancer, PCSD1. APDT-resistant PDX-derived organoids (PDOs) emerged when cultured without androgen or with the anti-androgen, enzalutamide. Transcriptomics revealed up-regulation of neurogenic and steroidogenic genes and down-regulation of DNA repair, cell cycle, circadian pathways and the severe acute respiratory syndrome (SARS)-CoV-2 host viral entry factors, ACE2 and TMPRSS2. Time course analysis of the cell cycle in live cells revealed that enzalutamide induced a gradual transition into a reversible dormant state as shown here for the first time at the single cell level in the context of multi-cellular, 3D living organoids using the Fucci2BL fluorescent live cell cycle tracker system. We show here a new mechanism of castration resistance in which enzalutamide induced dormancy and novel basal-luminal-like cells in bone metastatic prostate cancer organoids. These PDX organoids can be used to develop therapies targeting dormant APDT-resistant cells and host factors required for SARS-CoV-2 viral entry. | Lee, Sanghee; Mendoza, Theresa R.; Burner, Danielle N.; Muldong, Michelle T.; Wu, Christina C. N.; Arreola-Villanueva, Catalina; Zuniga, Abril; Greenburg, Olga; Zhu, William Y.; Murtadha, Jamillah; Koutouan, Evodie; Pineda, Naomi; Pham, Hao; Kang, Sung-Gu; Kim, Hyun Tae; Pineda, Gabriel; Lennon, Kathleen M.; Cacalano, Nicholas A.; Jamieson, Catriona H. M.; Kane, Christopher J.; Kulidjian, Anna A.; Gaasterland, Terry; Jamieson, Christina A. M. | Univ Calif San Diego, Dept Urol, La Jolla, CA 92093 USA; Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA; Rady Childrens Hosp, San Diego, CA 92123 USA; Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA; Korea Univ, Dept Urol, Coll Med, Seoul 02841, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu 41944, South Korea; Univ Calif Los Angeles, Dept Radiat Oncol, Los Angeles, CA 90095 USA; Scripps MD Anderson Canc Ctr, La Jolla, CA 92093 USA; Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA; Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA | 55940282600; 57209571517; 57193873609; 56020470100; 7501662114; 57544362100; 59057311500; 57542938200; 57542938300; 57542938400; 57543650300; 57543650400; 57544712700; 35995660400; 55739531300; 10045002900; 56607025800; 6603463071; 25649589800; 26643148200; 8735431000; 7003769747; 7006413274 | salee@health.ucsd.edu;theresa.mendoza09@gmail.com;danielleburner@gmail.com;mmuldong@health.ucsd.edu;c5wu@health.ucsd.edu;catalinaarreola95@gmail.com;abrilz2296@gmail.com;miakicheva@gmail.com;w.zhu@wustl.edu;jmurtadh@ucsd.edu;ekoutoua@ucsd.edu;naomicorral.nc@gmail.com;hpham0929@yahoo.com;kkangsung76@korea.ac.kr;urohtkim@gmail.com;gpineda@health.ucsd.edu;klennon@health.ucsd.edu;ncacalan@uda.edu;cjamieson@health.ucsd.edu;ckane@health.ucsd.edu;kulidjian.anna@scrippshealth.org;tgaasterland@ucsd.edu;camjamieson@health.ucsd.edu; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 1.06 | 2025-06-25 | 12 | 12 | androgen pathway directed therapy; angiotensin-converting enzyme 2; basal-luminal-like hybrid; bone metastatic prostate cancer; dormant; enzalutamide; patient-derived organoids; patient-derived xenograft; prostate cancer San Diego 1; SARS-CoV-2; transmembrane protease serine 2 | ANDROGEN RECEPTOR; STEM-CELLS; LUMINAL CELLS; PROMOTES; PHOSPHORYLATION; HETEROGENEITY; PROGRESSION; PLASTICITY; COVID-19; THERAPY | Androgen pathway directed therapy; Angiotensin-converting enzyme 2; Basal-luminal-like hybrid; Bone metastatic prostate cancer; Dormant; Enzalutamide; Patient-derived organoids; Patient-derived xenograft; Prostate cancer San Diego 1; SARS-CoV-2; Transmembrane protease serine 2 | androgen receptor; angiotensin converting enzyme 2; enzalutamide; host factor; transmembrane protease serine 2; androgen deprivation therapy; animal cell; animal experiment; animal model; Article; bone metastasis; cancer resistance; castration; castration resistant prostate cancer; cell cycle; cell level; circadian rhythm; controlled study; DNA repair; dormancy; down regulation; gene expression profiling; gene set enrichment analysis; human; human tissue; live cell imaging; male; mouse; nonhuman; organoid; Severe acute respiratory syndrome coronavirus 2; three dimensional cell culture; tissue culture; transcriptomics; tumor xenograft; upregulation; virus entry | English | 2022 | 2022-03 | 10.3390/ijms23063203 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Novel Plant Extract Ameliorates Metabolic Disorder through Activation of Brown Adipose Tissue in High-Fat Diet-Induced Obese Mice | Obesity is characterized by excessive body fat accumulation due to unbalanced energy intake and expenditure. Potential therapeutic targets for anti-obesity include the inhibition of white adipose tissue (WAT) hypertrophy and hyperplasia and the activation of brown adipose tissue (BAT). Not only the activation of BAT but also the browning of WAT have gained increasing attention in research fields as an alternative method in the prevention and treatment of obesity. Here, we investigated possible mechanisms underlying the anti-obesity effect of Phlomis umbrosa Turcz. root ethanol extract (PUE) in an obesogenic animal model. PUE treatment can reduce diet-induced obesity and modulate obesity-associated metabolic disorders, including insulin resistance, hepatic steatosis, and inflammation. In the liver, PUE improved hepatic steatosis by suppressing hepatic lipogenesis and lipid absorption while increasing biliary sterol excretion and hepatic fatty acid oxidation compared to the high-fat group. Moreover, PUE increased energy expenditure and regulated fecal lipid excretion, leading to reduced body weight gain. In particular, PUE remarkably activated the browning of subWAT via upregulation of the browning-related protein and gene expression and promoted BAT activation. In conclusion, these findings provide the potential therapeutic usefulness into the effects of PUE in the treatment of obesity and metabolic disorders. Furthermore, it suggests that PUE treatment can regulate energy metabolism via activating BAT and browning subWAT. | Kim, Ji-Won; Yang, Young-Mo; Kwon, Eun-Young; Choi, Ji-Young | Kyungpook Natl Univ, Dept Food Sci & Nutr, Daegu 41566, South Korea; Chosun Univ, Coll Pharm, Dept Pharm, Gwangju 61452, South Korea; Chosun Univ, Coll Nat Sci & Publ Hlth & Safety, Dept Food & Nutr, Gwangju 61452, South Korea | 57211318231; 56815912300; 15765422500; 57219113098 | jychoi@chosun.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 23 | 16 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 0.18 | 2025-06-25 | 1 | 2 | Phlomis umbrosa Turcz. (Labiatae) root; high-fat diet; hepatic steatosis; browning; thermogenesis; energy expenditure | INSULIN-RESISTANCE; HEPATIC STEATOSIS; LIVER; GLUCOSE; ASSAY; RAT | browning; energy expenditure; hepatic steatosis; high-fat diet; Phlomis umbrosa Turcz. (Labiatae) root; thermogenesis | Adipose Tissue, Brown; Adipose Tissue, White; Animals; Diet, High-Fat; Energy Metabolism; Fatty Liver; Insulin Resistance; Lipids; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Plant Extracts; Thermogenesis; alcohol; feces lipid; phlomis umbrosa extract; plant extract; unclassified drug; lipid; plant extract; adipose tissue; animal experiment; animal model; antiobesity activity; Article; body weight; body weight gain; brown adipose tissue; controlled study; diet-induced obesity; energy expenditure; energy metabolism; fatty acid oxidation; gene expression; insulin resistance; lipid absorption; lipid diet; lipid metabolism; lipid storage; lipogenesis; metabolic disorder; mouse; nonhuman; obesity; Phlomis; phlomis umbrosa; plant root; sterol excretion; thermogenesis; upregulation; adverse event; animal; brown adipose tissue; C57BL mouse; fatty liver; genetics; insulin resistance; metabolism; mouse mutant; obesity; white adipose tissue | English | 2022 | 2022-08 | 10.3390/ijms23169295 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Nuclear mRNA Export and Aging | The relationship between transcription and aging is one that has been studied intensively and experimentally with diverse attempts. However, the impact of the nuclear mRNA export on the aging process following its transcription is still poorly understood, although the nuclear events after transcription are coupled closely with the transcription pathway because the essential factors required for mRNA transport, namely TREX, TREX-2, and nuclear pore complex (NPC), physically and functionally interact with various transcription factors, including the activator/repressor and pre-mRNA processing factors. Dysregulation of the mediating factors for mRNA export from the nucleus generally leads to the aberrant accumulation of nuclear mRNA and further impairment in the vegetative growth and normal lifespan and the pathogenesis of neurodegenerative diseases. The optimal stoichiometry and density of NPC are destroyed during the process of cellular aging, and their damage triggers a defect of function in the nuclear permeability barrier. This review describes recent findings regarding the role of the nuclear mRNA export in cellular aging and age-related neurodegenerative disorders. | Park, Hyun-Sun; Lee, Jongbok; Lee, Hyun-Shik; Ahn, Seong Hoon; Ryu, Hong-Yeoul | Inje Univ, Coll Med, Dept Biochem, Busan 50834, South Korea; Hongik Univ, Dept Biol & Chem Engn, 2639 Sejong Ro, Sejong Si 30016, South Korea; Kyungpook Natl Univ, Coll Natl Sci, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Hanyang Univ, Coll Sci & Convergence Technol, Dept Mol & Life Sci, ERICA Campus, Ansan 15588, South Korea | ; Park, Hyeonsun/GSN-5362-2022; Lee, Jongbok/V-2096-2019 | 57189620033; 57187423600; 16316010200; 7401989611; 55889917800 | hspark@inje.ac.kr;jlee0917@hongik.ac.kr;leeh@knu.ac.kr;hoon320@hanyang.ac.kr;rhr4757@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 10 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 0.41 | 2025-06-25 | 13 | 12 | mRNA export; TREX; TREX-2; NPC; lifespan; neurodegenerative diseases | LIFE-SPAN; PORE COMPLEX; NUCLEOCYTOPLASMIC TRANSPORT; GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE; FUNCTIONAL COMPONENT; HISTONE SUMOYLATION; REPEAT EXPANSION; STRUCTURAL BASIS; BINDING PROTEIN | lifespan; mRNA export; neurodegenerative diseases; NPC; TREX; TREX-2 | Active Transport, Cell Nucleus; Cell Nucleus; Nuclear Pore; RNA Transport; RNA, Messenger; messenger RNA; nuclear RNA; messenger RNA; cell aging; degenerative disease; human; nonhuman; nuclear export; nuclear pore complex; Review; RNA processing; cell nucleus; genetics; metabolism; nuclear pore; nucleocytoplasmic transport; RNA transport | English | 2022 | 2022-05 | 10.3390/ijms23105451 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Editorial Material | Osteoclastogenesis and Osteogenesis | Kim, Jung-Eun | Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, BK21 Four KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea | 57209054588 | kjeun@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 2.59 | 2025-06-25 | 7 | 7 | Bone and Bones; Osteoclasts; Osteogenesis; bisphosphonic acid derivative; calcium binding protein; calvasculin; fatty acid amidase inhibitor; metallothionein III; mitogen activated protein kinase; pentraxin 3; reactive oxygen metabolite; bone regeneration; bone remodeling; cell aggregation; cell differentiation; Editorial; enzyme phosphorylation; gene expression; human; nonhuman; ossification; osteoblast; osteoclastogenesis; bone; bone development; osteoclast | English | 2022 | 2022-06 | 10.3390/ijms23126659 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Pharmacological Actions of 5-Hydroxyindolin-2 on Modulation of Platelet Functions and Thrombus Formation via Thromboxane A2 Inhibition and cAMP Production | Platelets play a very significant role in hemostasis while simultaneously posing a risk for the development of various cardiovascular diseases. Platelet-mediated issues can occur in blood vessels and trigger various medical problems. Therefore, controlling platelet function is important in the prevention of thrombosis. In this regard, we need to find compounds that provide potent antiplatelet activity with minimum side effects. Therefore, we examined the effect of 5-hydroxyindolin-2-one isolated from Protaetia brevitarsis larvae having antiplatelet properties and investigated different pathways that mediate the antiplatelet activity. We examined the effect of 5-hydroxyindolin-2-one (5-HI) on the regulation of phosphoproteins, thromboxane A(2) generation, and integrin alpha IIb beta 3 action. Our data showed that human platelet aggregation was inhibited by 5-HI (75, 100, 150, 200 mu M) without cytotoxicity, and it suppressed intracellular Ca2+ concentration through the regulation of inositol 1, 4, 5-triphosphate receptor I (Ser(1756)) and extracellular signal-regulated kinase (ERK). Moreover, collagen-elevated thromboxane A(2) production and alpha IIb beta 3 action were inhibited by 5-HI through the regulation of cytosolic phospholipase A(2) (cPLA(2)), mitogen-activated protein kinase p38 (p38(MAPK)), vasodilator-stimulated phosphoprotein (VASP), phosphoinositide 3-kinase (PI3K), and Akt (protein kinase B). Therefore, we suggested that 5-HI could be a potential substance for the prevention of thrombosis-mediated thrombosis. | Kwon, Hyuk-Woo; Kim, Sung Dae; Rhee, Man Hee; Shin, Jung-Hae | Far East Univ, Dept Biomed Lab Sci, Eumseong 27601, South Korea; Far East Univ, Dept Microbiol, Resource Res Inst, Eumseong 27601, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Sch Med, Daegu 41944, South Korea | Rhee, Man/O-5705-2016 | 55200547400; 55156746000; 57211035357; 56244056800 | rheemh@knu.ac.kr;mlsjshin@naver.com; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 23 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 0.53 | 2025-06-25 | 6 | 6 | 5-hydroxyindolin-2-one; Protaetia brevitarsis larvae; alpha IIb beta 3 action; granule secretion; clot retraction | MEDIATED CALCIUM-ENTRY; ACTIVATION; PHOSPHORYLATION; AGGREGATION; MECHANISMS; 3-KINASES; PATHWAY; DISEASE; CELLS | 5-hydroxyindolin-2-one; clot retraction; granule secretion; Protaetia brevitarsis larvae; αIIbβ3 action | Blood Platelets; Humans; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Thromboxanes; 5 hydroxyindolin 2 one; alpha2 integrin; alpha2b integrin; antithrombocytic agent; beta3 integrin; calcium ion; collagen; cyclic AMP; cyclic GMP; cytosolic phospholipase A2; fibrinogen; fibrinogen receptor; fibronectin; inositol 1,4,5 triphosphate receptor I; inositol 1,4,5 trisphosphate receptor; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 14; mitogen activated protein kinase p38; phosphatidylinositol 3 kinase; phosphoprotein; protein kinase B; serine; thromboxane A2; unclassified drug; vasodilator stimulated phosphoprotein; antithrombocytic agent; phosphatidylinositol 3 kinase; thromboxane; antiplatelet activity; Article; blood clot retraction; blood clotting; calcium cell level; calcium homeostasis; calcium mobilization; concentration response; controlled study; drug cytotoxicity; drug mechanism; fibrin clot; human; human cell; IC50; insect; larva; nonhuman; Protaetia brevitarsis; protein dephosphorylation; protein phosphorylation; protein synthesis; regulatory mechanism; signal transduction; thrombocyte aggregation; thrombocyte function; thrombosis; thrombosis prevention; metabolism; phosphorylation; thrombocyte; thrombocyte activation | English | 2022 | 2022-12 | 10.3390/ijms232314545 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation | Cancer is one of the deadliest non communicable diseases. Numerous anticancer medications have been developed to target the molecular pathways driving cancer. However, there has been no discernible increase in the overall survival rate in cancer patients. Therefore, innovative chemo-preventive techniques and agents are required to supplement standard cancer treatments and boost their efficacy. Fruits and vegetables should be tapped into as a source of compounds that can serve as cancer therapy. Phytochemicals play an important role as sources of new medication in cancer treatment. Some synthetic and natural chemicals are effective for cancer chemoprevention, i.e., the use of exogenous medicine to inhibit or impede tumor development. They help regulate molecular pathways linked to the development and spread of cancer. They can enhance antioxidant status, inactivating carcinogens, suppressing proliferation, inducing cell cycle arrest and death, and regulating the immune system. While focusing on four main categories of plant-based anticancer agents, i.e., epipodophyllotoxin, camptothecin derivatives, taxane diterpenoids, and vinca alkaloids and their mode of action, we review the anticancer effects of phytochemicals, like quercetin, curcumin, piperine, epigallocatechin gallate (EGCG), and gingerol. We examine the different signaling pathways associated with cancer and how inflammation as a key mechanism is linked to cancer growth. | Ahmed, Muhammad Bilal; Ul Islam, Salman; Alghamdi, Abdullah A. A.; Kamran, Muhammad; Ahsan, Haseeb; Lee, Young Sup | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Cecos Univ, Dept Pharm, St 1,Sect F 5 Phase 6 Hayatabad, Peshawar 25000, Pakistan; Albaha Univ, Fac Sci, Dept Biol, Albaha 65527, Saudi Arabia; Univ Western Australia, Sch Mol Sci, M310,35 Stirling Hwy, Perth, WA 6009, Australia; Univ Peshawar, Fac Life & Environm Sci, Dept Pharm, Peshawar 25120, Pakistan | Kamran, Muhammad/C-8121-2018; Ahmed, Muhammad/ABA-8180-2021; Alghamdi, Abdullah/AEO-0020-2022 | 58689879600; 56985186700; 57410884000; 57462900300; 57531232400; 36013628200 | yselee@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 24 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 4.33 | 2025-06-25 | 42 | 50 | phytochemicals; chemoprevention; cancer; signaling pathways; cell cycle; apoptosis; inflammation | DNA TOPOISOMERASE-II; CELL-CYCLE ARREST; NF-KAPPA-B; LUNG-CANCER; PROSTATE-CANCER; COLORECTAL-CANCER; INDUCED APOPTOSIS; GREEN TEA; IN-VIVO; NATURAL COMPOUNDS | apoptosis; cancer; cell cycle; chemoprevention; inflammation; phytochemicals; signaling pathways | Antineoplastic Agents; Humans; Inflammation; Neoplasms; Phytochemicals; Signal Transduction; antineoplastic agent; cabazitaxel; camptothecin; combretastatin A4; curcumin; docetaxel; epigallocatechin gallate; etoposide; gingerol; homoharringtonine; ingenol mebutate; irinotecan; paclitaxel; phytochemical; piperine; quercetin; teniposide; topotecan; vinblastine; vincristine; vindesine; vinflunine; vinorelbine tartrate; antineoplastic agent; phytochemical; Article; cell cycle arrest; cell death; inflammation; metastasis; signal transduction; human; inflammation; metabolism; neoplasm | English | 2022 | 2022-12 | 10.3390/ijms232415765 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Pigmentation and Flavonoid Metabolite Diversity in Immature 'Fuji' Apple Fruits in Response to Lights and Methyl Jasmonate | Artificial pigmentation of apple fruits has been intensely evaluated to generate less pigmented red apples, which are profitable because of the changes in fruit quality. In this study, we analyzed the diversity of flavonoids and the patterns of flavonoid metabolic gene expression under light irradiation with or without methyl jasmonate (MeJA) treatment in immature (S1) and color-turning (S2) staged 'Fuji' apples. Further, we assessed the metabolic regulation at the gene level between anthocyanin and flavonol in light-responsive apple skins. UV-B exposure within 3 days was found to significantly stimulate anthocyanin accumulation in apple skin compared to other light exposure. S1 skin was more sensitive to UV-B and MeJA treatment, in the aspect of indaein accumulation. The enhancement of apple pigmentation following treatment with adequate levels of UV-B and MeJA was maximized at approximately 72 h. Red (range from 4.25 to 17.96 mu g center dot g(-1) DW), blue (range from 4.59 to 9.17 mu g center dot g(-1) DW) and UV-A (range from 3.98 to 19.12 mu g center dot g(-1) DW) lights contributed to the induction of idaein content. Most genes related to the flavonoid pathways increased their expression under UV-B exposure, including the gene expression of the transcription factor, MdMYB10, a well-known upstream factor of flavonoid biosynthesis in apples. The boosted upregulation of MdMYB10, MdCHS, MdF3H MdLDOX, and MdUFGT genes due to MeJA in UV-B was found and may contribute the increase of idaein. UV-A and UV-B caused higher quercetin glycoside content in both S1 and S2 apple skins than longer wavelengths, resulting in significant increases in quercetin-3-O-galactoside and quercetin-3-O-glucoside. These results suggest that the application of adequate UV-B with MeJA in less-pigmented postharvest apples will improve apple color quality within a short period. | Ryu, Jung-A; Duan, Shucheng; Jeong, Ho-Young; Lee, Chanhui; Kang, In-Kyu; Eom, Seok Hyun | Gyeongsangbuk Do Agr Res & Extens Serv, Daegu 41404, South Korea; Kyungpook Natl Univ, Dept Hort, Daegu 41566, South Korea; Kyung Hee Univ, Coll Life Sci, Dept Hort Biotechnol, Yongin 17104, South Korea; Kyung Hee Univ, Coll Life Sci, Dept Plant & Environm New Resources, Yongin 17104, South Korea | 57216744726; 57221500551; 57207963667; 23005580300; 56577308800; 15836623800 | jaryu@korea.kr;dsc97@khu.ac.kr;ratank@khu.ac.kr;chan521@khu.ac.kr;kangik@knu.ac.kr;se43@khu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 2.03 | 2025-06-25 | 24 | 25 | anthocyanin; apple skin; artificial light; idaein; quercetin glycosides; ultraviolet B | UV-B; ANTHOCYANIN BIOSYNTHESIS; ETHYLENE BIOSYNTHESIS; QUERCETIN GLYCOSIDES; EXPRESSION ANALYSIS; ABSCISIC-ACID; RED; SKIN; GENES; ACCUMULATION | Anthocyanin; Apple skin; Artificial light; Idaein; Quercetin glycosides; Ultraviolet B | Acetates; Anthocyanins; Cyclopentanes; Flavonoids; Fruit; Gene Expression Regulation, Plant; Malus; Oxylipins; Pigmentation; Ultraviolet Rays; alcohol; anthocyanin; deoxyribonuclease; flavonoid; formic acid; glycoside; jasmonic acid methyl ester; quercetin; acetic acid; cyclopentane derivative; flavonoid; jasmonic acid methyl ester; oxylipin; apple; Article; biosynthesis; centrifugation; chlorophyll content; controlled study; gene; gene expression; gene overexpression; irradiation; light exposure; metabolic regulation; metabolite; nonhuman; pH; pigmentation; plant cell; quantitative analysis; real time reverse transcription polymerase chain reaction; reversed phase high performance liquid chromatography; RNA extraction; skin; spectrophotometry; ultrasound assisted extraction; ultraviolet A radiation; ultraviolet B radiation; fruit; gene expression regulation; growth, development and aging; Malus; metabolism; pigmentation; ultraviolet radiation | English | 2022 | 2022-02 | 10.3390/ijms23031722 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Preparation of Highly Crystalline Silk Nanofibrils and Their Use in the Improvement of the Mechanical Properties of Silk Films | Due to their commendable biocompatibility, regenerated silk fibroin (RSF) films have attracted considerable research interest. However, the poor mechanical properties of RSF films have limited their use in various biomedical applications. In this study, a novel, highly crystalline silk fibril was successfully extracted from silk by combining degumming with ultrasonication. Ultrasonication accelerated the development of silk nanofibrils measuring 130-200 nm on the surface of the over-degummed silk fibers, which was confirmed via scanning electron microscopy. Additionally, the crystallinity index of silk fibril was found to be significantly higher (similar to 68%) than that of conventionally degummed silk (similar to 54%), as confirmed by the Fourier-transform infrared (FTIR) spectroscopy results. Furthermore, the breaking strength and elongation of the RSF film were increased 1.6 fold and 3.4 fold, respectively, following the addition of 15% silk nanofibrils. Thus, the mechanical properties of the RSF film were remarkably improved by the addition of the silk nanofibrils, implying that it can be used as an excellent reinforcing material for RSF films. | Lee, Ji Hye; Park, Bo Kyung; Um, In Chul | Kyungpook Natl Univ, Dept Biofibers & Biomat Sci, Daegu 41566, South Korea; Oak Ridge Natl Lab, Bldg & Transportat Sci Div, One Bethel Valley Rd, Oak Ridge, TN 37831 USA | 57203144688; 56883541200; 7006725707 | icum@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 19 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 1.15 | 2025-06-25 | 12 | 13 | silk nanofibril; composite film; mechanical properties; degumming; ultrasonication | ELECTRO-SPINNING PERFORMANCE; STRUCTURAL CHARACTERISTICS; MOLECULAR-WEIGHT; BOMBYX-MORI; GELATION BEHAVIOR; NONWOVEN FABRICS; FIBROIN; SERICIN; DISSOLUTION; WET | composite film; degumming; mechanical properties; silk nanofibril; ultrasonication | Fibroins; Silk; Spectroscopy, Fourier Transform Infrared; crystallin; nanocomposite; nanofiber; silk fibroin; sodium carbonate; sorbitan stearate; fibroin; silk; aqueous solution; Article; Bombyx mori; breaking strength; crystal structure; electrospinning; field emission; field emission scanning electron microscopy; Fourier transform infrared spectroscopy; mechanics; reverse osmosis; scanning electron microscopy; surface property; ultrasound; chemistry; infrared spectroscopy | English | 2022 | 2022-10 | 10.3390/ijms231911344 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | PRP4 Induces Epithelial-Mesenchymal Transition and Drug Resistance in Colon Cancer Cells via Activation of p53 | Pre-mRNA processing factor 4B (PRP4) promotes pre-mRNA splicing and signal transduction. Recent studies have shown that PRP4 modulates the assembly of actin cytoskeleton in cancer cells and induces epithelial-mesenchymal transition (EMT) and drug resistance. PRP4 displays kinase domain-like cyclin-dependent kinases and mitogen-activated protein kinases, making it capable of phosphorylating p53 and other target proteins. In the current study, we report that PRP4 induces drug resistance and EMT via direct binding to the p53 protein, inducing its phosphorylation. Moreover, PRP4 overexpression activates the transcription of miR-210 in a hypoxia-inducible factor 1 alpha (HIF-1 alpha)-dependent manner, which activates p53. The involvement of miR-210 in the activation of p53 was confirmed by utilizing si-miR210. si-miR210 blocked the PRP4-activated cell survival pathways and reversed the PRP4-induced EMT phenotype. Moreover, we used deferoxamine as a hypoxia-mimetic agent, and si-HIF to silence HIF-1 alpha. This procedure demonstrated that PRP4-induced EMT and drug resistance emerged in response to consecutive activation of HIF-1 alpha, miR-210, and p53 by PRP4 overexpression. Collectively, our findings suggest that the PRP4 contributes to EMT and drug resistance induction via direct interactions with p53 and actions that promote upregulation of HIF-1 alpha and miR-210. We conclude that PRP4 is an essential factor promoting cancer development and progression. Specific PRP4 inhibition could benefit patients with colon cancer. | Ul Islam, Salman; Ahmed, Muhammad Bilal; Sonn, Jong-Kyung; Jin, Eun-Jung; Lee, Young-Sup | Cecos Univ, Dept Pharm, Peshawar 25000, Pakistan; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu 41566, South Korea; Wonkwang Univ, Coll Nat Sci, Dept Biol Sci, Iksan 54538, South Korea | Ahmed, Muhammad/ABA-8180-2021 | 56985186700; 58689879600; 35580853300; 34570037700; 36013628200 | dr_ssulman@yahoo.com;mbilalknu@gmail.com;sonnjk@knu.ac.kr;jineunjung@wonkwang.ac.kr;yselee@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 1.24 | 2025-06-25 | 10 | 14 | PRP4; miR-210; HCT116; p53; EMT; drug resistance | TUMOR-SUPPRESSOR P53; NEGATIVE REGULATION; MASTER REGULATORS; MICRORNA MIR-210; HYPOXIA; EXPRESSION; GENE; TARGET; MUTATIONS; INVASION | Drug resistance; EMT; HCT116; MiR-210; P53; PRP4 | Cell Line, Tumor; Colonic Neoplasms; Drug Resistance; Epithelial-Mesenchymal Transition; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; MicroRNAs; RNA Precursors; Tumor Suppressor Protein p53; annexin; F actin; fluorescein isothiocyanate; hypoxia inducible factor 1alpha; messenger RNA; messenger RNA precursor; microRNA; microRNA 210; penicillin derivative; Pre mRNA processing factor 4B; protein p53; resveratrol; streptomycin; unclassified drug; hypoxia inducible factor 1alpha; microRNA; protein p53; RNA precursor; animal tissue; apoptosis assay; Article; cell invasion; colon cancer; down regulation; epithelial mesenchymal transition; gene expression; gene overexpression; gene silencing; genetic transfection; HCT 116 cell line; HCT 15 cell line; human; human cell; immunofluorescence; immunohistochemistry; immunoprecipitation; in vivo study; kinase assay; microarray analysis; mouse; nonhuman; PC3-PIP cell line; phenotype; polyacrylamide gel electrophoresis; protein expression; real time polymerase chain reaction; tumor growth; tumor volume; upregulation; Western blotting; colon tumor; drug resistance; epithelial mesenchymal transition; genetics; hypoxia; metabolism; tumor cell line | English | 2022 | 2022-03 | 10.3390/ijms23063092 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | QTL Mapping and Candidate Gene Analysis for Seed Germination Response to Low Temperature in Rice | Low temperature is a serious threat to the seed emergence of rice, which has become one of the main limiting factors affecting rice production in the world. It is of great significance to find the candidate genes controlling low-temperature tolerance during seed germination and study their functions for breeding new rice cultivars with immense low-temperature tolerance during seed germination. In the current experiment, 120 lines of the Cheongcheong Nagdong Double Haploid (CNDH) population were used for quantitative trait locus (QTL) analysis of low-temperature germinability. The results showed a significant difference in germination under low different temperature (LDT) (15 degrees C, 20 degrees C) conditions. In total, four QTLs were detected on chromosome 3, 6, and 8. A total of 41 genes were identified from all the four QTLs, among them, 25 genes were selected by gene function annotation and further screened through quantitative real-time polymerase chain reaction (qRT-PCR). Based on gene function annotation and level of expression under low-temperature, our study suggested the OsGPq3 gene as a candidate gene controlling viviparous germination, ABA and GA signaling under low-temperature. This study will provide a theoretical basis for marker-assisted breeding and lay the basis for further mining molecular mechanisms of low-temperature germination tolerance in rice. | Kim, Nari; Jan, Rahmatullah; Park, Jae-Ryoung; Asif, Saleem; Zhao, Dan-Dan; Kim, Eun-Gyeong; Jang, Yoon-Hee; Eom, Gyu-Hyeon; Lee, Gang-Seob; Kim, Kyung-Min | Kyungpook Natl Univ, Grad Sch, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea; Rural Dev Adm, Crop Breeding Div, Natl Inst Crop Sci, Wonju 55365, South Korea; Rural Dev Adm, Dept Agr Biotechnol, Natl Inst Agr Sci, Jeonju 54874, South Korea | ; Kim, Kyung-Min Kim/C-7007-2014; ZHAO, DANDAN/HIK-2130-2022; Jan, Rahmatullah/AIC-3439-2022 | 57395985700; 57201981969; 57211205505; 57396413700; 57459517300; 57221496070; 57219901992; 57771626600; 25927158200; 34868260300 | jennynari@hanmail.net;rehmatbot@yahoo.com;icd92@naver.com;saleemasif10@gmail.com;qx288mm@naver.com;dkqkxk632@naver.com;uniunnie@naver.com;znfnfn978@naver.com;kangslee@korea.kr;kkm@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 13 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 0.97 | 2025-06-25 | 10 | 11 | low-temperature; seed germination; Cheongcheong Nagdong double haploid; quantitative trait locus; viviparous germination; marker-assisted breeding | ABSCISIC-ACID; ARABIDOPSIS; DORMANCY; IDENTIFICATION; GIBBERELLINS; PLANT; LOCI | Cheongcheong Nagdong double haploid; low-temperature; marker-assisted breeding; quantitative trait locus; seed germination; viviparous germination | Genetic Association Studies; Germination; Oryza; Plant Breeding; Seeds; Temperature; abscisic acid; Article; chromosome 3; gene expression level; gene function; genetic analysis; germination; low temperature; marker assisted breeding; nonhuman; phenotype; plant gene; quantitative trait locus mapping; real time polymerase chain reaction; rice; signal transduction; viviparity; genetic association study; genetics; germination; Oryza; plant breeding; plant seed; temperature | English | 2022 | 2022-07 | 10.3390/ijms23137379 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Radar Sensor-Based Estimation of Vehicle Orientation for Autonomous Driving | Automotive sensors are essential to autonomous driving, which performs various functions to perceive the surrounding environment. Among the various functions of the automotive sensors, the estimation of vehicle orientation is considered significant in responding to unpredictable situations in a dynamic driving environment. In this article, we propose a method of estimating the vehicle orientation using a cascaded multiple-input multiple-output (MIMO) frequency-modulated continuous-wave (FMCW) radar system. The radar signal is collected by varying the orientation angle of the vehicle, and the point cloud data corresponding to the vehicle are extracted through signal preprocessing. Because the processed point cloud data are distributed along the axis of vehicle orientation, the orientation angle can be estimated by applying regression algorithms. We used the principal component analysis (PCA), decision tree, and convolutional neural network (CNN) algorithms for regression and compared their performances. The comparison of various estimation methods showed that the proposed method of using the CNN framework can accurately estimate the orientation angle of a vehicle within a root mean square error (RMSE) of 4 degrees. | Lim, Sohee; Jung, Jaehoon; Lee, Byeong-ho; Choi, Jeongsik; Kim, Seong-Cheol | Seoul Natl Univ SNU, Dept Elect & Comp Engn, Seoul 08826, South Korea; Seoul Natl Univ SNU, Inst New Media & Commun INMC, Seoul 08826, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | ; Choi, Jeongsik/ABA-6906-2020 | 57203931160; 59911066400; 57195528668; 58534394200; 22334016200 | gml0488@maxwell.snu.ac.kr;jay623@maxwell.snu.ac.kr;bhlee@maxwell.snu.ac.kr;jeongsik.choi@knu.ac.kr;sckim@maxwell.snu.ac.kr; | IEEE SENSORS JOURNAL | IEEE SENS J | 1530-437X | 1558-1748 | 22 | 22 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION;PHYSICS, APPLIED | 2022 | 4.3 | 23.0 | 1.34 | 2025-06-25 | 14 | 15 | Radar; Sensors; Point cloud compression; Estimation; Radar antennas; MIMO communication; Antenna measurements; Automotive radar; autonomous driving; frequency-modulated continuous-wave (FMCW) radar; regression; vehicle orientation | Automotive radar; autonomous driving; frequency-modulated continuous-wave (FMCW) radar; regression; vehicle orientation | Automobile drivers; Automotive radar; Continuous wave radar; Decision trees; Frequency estimation; Frequency modulation; Mean square error; MIMO radar; Neural networks; Principal component analysis; Radar antennas; Radar measurement; Antennas measurement; Automotive radar; Autonomous driving; Frequency-modulated-continuous-wave radars; Multiple-input multiple-output communications; Point cloud compression; Point-clouds; Radars antennas; Regression; Vehicle orientation; Regression analysis | English | 2022 | 2022-11-15 | 10.1109/jsen.2022.3210579 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory Diseases | Oxidative stress is a major component of cell damage and cell fat, and as such, it occupies a central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2-related factor 2 (Nrf2), a key transcription factor that coordinates expression of genes encoding antioxidant and detoxifying enzymes, is regulated primarily by Kelch-like ECH-associated protein 1 (Keap1). However, involvement of the Keap1-Nrf2 pathway in tissue and organism homeostasis goes far beyond protection from cellular stress. In this review, we focus on evidence for Nrf2 pathway dysfunction during development of several metabolic/inflammatory disorders, including diabetes and diabetic complications, obesity, inflammatory bowel disease, and autoimmune diseases. We also review the beneficial role of current molecular Nrf2 agonists and summarize their use in ongoing clinical trials. We conclude that Nrf2 is a promising target for regulation of numerous diseases associated with oxidative stress and inflammation. However, more studies are needed to explore the role of Nrf2 in the pathogenesis of metabolic/inflammatory diseases and to review safety implications before therapeutic use in clinical practice. | Kim, Min-Ji; Jeon, Jae-Han | Kyungpook Natl Univ Hosp, Dept Endocrinol Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Internal Med, Daegu 41404, South Korea | ; Kim, Min-Ji/Z-5205-2019 | 57206189095; 36910340400 | irisfullip@naver.com;jeonjh@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 23 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 5.6 | 23.0 | 1.77 | 2025-06-25 | 53 | 52 | Nrf2; oxidative stress; metabolic disease; inflammatory disease; clinical trials | NF-KAPPA-B; TRANSCRIPTION FACTOR NRF2; DIET-INDUCED OBESITY; PANCREATIC BETA-CELLS; OXIDATIVE STRESS; ANTIOXIDANT RESPONSE; REACTIVE OXYGEN; SIGNALING PATHWAY; DIMETHYL FUMARATE; KEAP1-NRF2 SYSTEM | Clinical trials; Inflammatory disease; Metabolic disease; Nrf2; Oxidative stress | Antioxidants; GA-Binding Protein Transcription Factor; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Oxidative Stress; aj 201; alpha cyclodextrin; bardoxolone methyl; curcumin; cyclic AMP; dimethyl fumarate; heme oxygenase 1; histone acetyltransferase; histone deacetylase 3; imidazole; interleukin 6; kelch like ECH associated protein 1; oltipraz; omaveloxolone; quercetin; resveratrol; retinoic acid receptor; retinoid X receptor; sequestosome 1; sulforadex; sulforaphane; superoxide dismutase; synaptotagmin I; transcription factor Maf; transcription factor Nrf2; unclassified drug; ursodeoxycholic acid; antioxidant; GA binding protein; kelch like ECH associated protein 1; transcription factor Nrf2; acne vulgaris; adipogenesis; adrenoleukodystrophy; Alport syndrome; amyotrophic lateral sclerosis; asthma; autoregulation; basic leucine zipper motif; brain hemorrhage; cataract; cell stress; cerebrovascular accident; chromatin immunoprecipitation; chronic obstructive lung disease; conformational transition; coronavirus disease 2019; depression; diabetes mellitus; diabetic complication; disease activity; drug receptor binding; energy expenditure; focal glomerulosclerosis; Friedreich ataxia; gene expression; homeostasis; human; Huntington chorea; inflammation; inflammatory bowel disease; inflammatory disease; insulin resistance; kidney polycystic disease; liver cirrhosis; metabolic disorder; metabolic syndrome X; mitochondrial myopathy; multiple sclerosis; muscular dystrophy; nonalcoholic fatty liver; nonhuman; nuclear magnetic resonance spectroscopy; obesity; oxidative stress; Parkinson disease; phase 1 clinical trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); phosphorylation; pregnancy diabetes mellitus; protein expression; protein processing; psoriatic arthritis; pulmonary hypertension; Review; rheumatoid arthritis; schizophrenia; scleroderma; spinocerebellar degeneration; subarachnoid hemorrhage; systemic lupus erythematosus; ubiquitination; ulcerative colitis; upregulation; metabolism | English | 2022 | 2022-03 | 10.3390/ijms23052846 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: