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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | TXS 1206+549: a new γ-ray-detected narrow-line Seyfert 1 galaxy at redshift 1.34? | Radio and gamma-ray loud narrow-line Seyfert 1 galaxies (NLS1s) are unique objects to study the formation and evolution of relativistic jets, as they are believed to have high accretion rates and powered by low mass black holes contrary to that known for blazars. However, only about a dozen gamma-ray-detected NLS1s (gamma-NLS1s) are known to date and all of them are at z <= 1. Here, we report the identification of a new gamma-ray-emitting NLS1 TXS 1206 + 549 at z = 1.344. A near-infrared spectrum taken with the Subaru Telescope showed H beta emission line with FWHM of 1194 +/- 77 km s(-1) and weak [OIII] emission line but no optical FeII lines, due to the limited wavelength coverage and poor signal-to-noise ratio. However, UV FeII lines are present in the SDSS optical spectrum. The source is very radio-loud, unresolved, and has a flat radio spectrum. The broad-band spectral energy distribution of the source has the typical two hump structure shown by blazars and other gamma-NLS1s. The source exhibits strong variability at all wavelengths such as the optical, infrared, and gamma-ray bands. All these observed characteristics show that TXS 1206 + 549 is the most distant gamma-NLS1 known to date. | Rakshit, Suvendu; Schramm, Malte; Stalin, C. S.; Tanaka, I; Paliya, Vaidehi S.; Pal, Indrani; Kotilainen, Jari; Shin, Jaejin | Aryabhatta Res Inst Observat Sci, Naini Tal 263002, India; Univ Turku, Finnish Ctr Astron ESO FINCA, Quantum, Vesilinnantie 5, Turku 20014, Finland; Saitama Univ 255 Shimo Okubo, Grad Sch Sci & Engn, Sakura Ku, Saitama, Saitama 3388570, Japan; Indian Inst Astrophys, Block 2, Bangalore 560034, Karnataka, India; Natl Astron Observ Japan, Subaru Telescope, 650 North A Ohoku Pl, Hilo, HI 96720 USA; Deutsch Elektronen Synchrotron DESY, Platanenallee 6, D-15738 Zeuthen, Germany; Univ Turku, Dept Phys & Astron, Tuorla Observ, FI-20014 Turku 20014, Finland; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 41566, South Korea | 55572266300; 14833238000; 6603346246; 7402517496; 55582114000; 57550015500; 55924792900; 55554622900 | suvenduat@gmail.com;stalin@iiap.res.in; | MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY | MON NOT R ASTRON SOC | 0035-8711 | 1365-2966 | 504 | 1 | SCIE | ASTRONOMY & ASTROPHYSICS | 2021 | 5.235 | 23.9 | 0.56 | 2025-07-30 | 8 | 8 | galaxies: active; galaxies: jets; galaxies: Seyfert; gamma rays: galaxies | DIGITAL SKY SURVEY; BLACK-HOLE MASSES; ACTIVE GALACTIC NUCLEI; GENERAL PHYSICAL-PROPERTIES; RADIO-LOUD; CATALOG; QUASARS; 1ST; VARIABILITY; EMISSION | Galaxies: active; galaxies: jets; galaxies: Seyfert; gamma rays: galaxies | English | 2021 | 2021-06 | 10.1093/mnrasl/slab031 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Antioxidant Effect of Wheat Germ Extracts and Their Antilipidemic Effect in Palmitic Acid-Induced Steatosis in HepG2 and 3T3-L1 Cells | Wheat germ (WG) is a by-product of wheat milling and comprises many bioactive compounds. This study aimed to compare the antioxidant and antilipidemic effects of different WG extracts (WGEs) by analyzing candidate bioactive compounds such as carotenoids, tocopherols, gamma-oryzanol, and biogenic amines by reversed-phase high-performance liquid chromatography. Antioxidant activity was determined using the ABTS, DPPH, and FRAP assays. The antilipidemic effect was evaluated in palmitic acid-induced steatosis in HepG2 hepatocytes and 3T3-L1 adipocytes. Cellular lipid accumulation was assessed by Oil Red O staining and a cellular triglyceride content assay. All analyzed WGEs showed significant antioxidant potential, although some bioactive compounds, such as carotenoids, tocopherols, and gamma-oryzanol, were the highest in the ethanol extract. Correlation analysis revealed the antioxidant potential of all identified biogenic amines except for spermidine. Ethanol and n-hexane extracts significantly inhibited cellular lipid accumulation in cell models. These results suggest that WGEs exhibit promising antioxidant potential, with a variety of bioactive compounds. Collectively, the findings of this study suggest that bioactive compounds in WGEs attenuate plasma lipid and oxidation levels. In conclusion, WG can be used as a natural antioxidant and nutraceutical using appropriate solvents and extraction methods. | Liaqat, Humna; Kim, Kyeong Jin; Park, Soo-yeon; Jung, Sung Keun; Park, Sung Hee; Lim, Seokwon; Kim, Ji Yeon | Seoul Natl Univ Sci & Technol, Dept Food Sci & Technol, 232 Gongneung Ro, Seoul 01811, South Korea; Seoul Natl Univ Sci & Technol, Dept Nano Bio Engn, 232 Gongneung Ro, Seoul 01811, South Korea; Seoul Natl Univ Sci & Technol, Lab Nanobio, 232 Gongneung Ro, Seoul 01811, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Gachon Univ, Coll Bionano Technol, Dept Food Sci & Biotechnol, 1342 Seongnam Daero, Seongnam Si 13120, South Korea | ; Kim, Joo/X-7562-2019; Park, Soo-yeon/HOH-1638-2023; Jung, SUNG KEUN/AGR-2623-2022 | 58234647200; 57204269550; 56498086600; 35310491400; 57188802513; 36183480900; 55873676800 | humnaliaqat710@gmail.com;jinnykim@seoultech.ac.kr;sooyeon.park@seoultech.ac.kr;skjung04@knu.ac.kr;sunghpark@seoultech.ac.kr;slim@gachon.ac.kr;jiyeonk@seoultech.ac.kr; | FOODS | FOODS | 2304-8158 | 10 | 5 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 5.561 | 24.0 | 2.16 | 2025-07-30 | 22 | 29 | wheat germ extracts; bioactive compounds; antioxidants; antilipidemic effect | LIPID-ACCUMULATION; BIOGENIC-AMINES; OLEIC-ACID; RICE BRAN; GAMMA-ORYZANOL; CAROTENOIDS; CHOLESTEROL; QUANTIFICATION; PROFILES; CAPACITY | Antilipidemic effect; Antioxidants; Bioactive compounds; Wheat germ extracts | English | 2021 | 2021-05 | 10.3390/foods10051061 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Comparison of Morphological and Physicochemical Properties of a Floury Rice Variety upon Pre-Harvest Sprouting | Pre-harvest sprouting (PHS) severely reduces rice grain yield, significantly affects grain quality, and leads to substantial economic loss. In this study, we aimed to characterize the physicochemical properties and processing quality of the Garumi 2 flour rice variety under PHS conditions and compare them with those of the Seolgaeng, Hangaru, Shingil, and Ilpum rice varieties and the Keumkang wheat variety. Analysis of the molecular structure of starch revealed uniform starch granules, increased proportions of short-chain amylopectin in DP 6-12 (51.0-55.3%), and enhanced crystallinity (30.7-35.7%) in rice varieties for flour compared with the Ilpum cooking rice variety. PHS significantly altered the starch structure and gelatinization properties of Garumi 2. It also caused surface pitting and roughness in Garumi 2 starch granules and decreased their crystallinity. Collectively, the findings of this study provide important novel insights into the effects of PHS on the physicochemical properties of Garumi 2 floury rice for flour. | Han, Chae-Min; Shin, Jong-Hee; Kwon, Jung-Bae; Kim, Jong-Soo; Won, Jong-Gun; Kim, Jong-Sang | Gyeongsangbuk Do Prov Agr Res & Extens Serv, Div Crops Res, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Major Food Biomat, Daegu 41566, South Korea | 57222965378; 55239526000; 57222961523; 57222962056; 57222964146; 37106950100 | tastypeach86@korea.kr;szzong91@korea.kr;borikae@korea.kr;jskim0429@korea.kr;ricewon@korea.kr;jongsangkim@gmail.com; | FOODS | FOODS | 2304-8158 | 10 | 4 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 5.561 | 24.0 | 0.98 | 2025-07-30 | 11 | 12 | crystallinity; gelatinization; pre-harvest sprouting; rice; rice flour; starch structure | CHAIN-LENGTH; BROWN RICE; STARCH; GELATINIZATION; AMYLOPECTIN; GERMINATION; VISCOSITY; ENDOSPERM; WHEAT | Crystallinity; Gelatinization; Pre-harvest sprouting; Rice; Rice flour; Starch structure | English | 2021 | 2021-04 | 10.3390/foods10040746 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Could Japonica Rice Be an Alternative Variety for Increased Global Food Security and Climate Change Mitigation? | The growing importance of rice globally over the past three decades is evident in its strategic place in many countries' food security planning policies. Still, its cultivation emits substantial greenhouse gases (GHGs). The Indica and Japonica sub-species of Oryza sativa L. are mainly grown, with Indica holding the largest market share. The awareness, economics, and acceptability of Japonica rice in a food-insecure Indica rice-consuming population were surveyed. The impact of parboiling on Japonica rice was studied and the factors which most impacted stickiness were investigated through sensory and statistical analyses. A comparison of the growing climate and greenhouse gas emissions of Japonica and Indica rice was carried out by reviewing previous studies. Survey results indicated that non-adhesiveness and pleasant aroma were the most preferred properties. Parboiling treatment altered Japonica rice's physical and chemical properties, introducing gelatinization of starch and reducing adhesiveness while retaining micronutrient concentrations. Regions with high food insecurity and high consumption of Indica rice were found to have suitable climatic conditions for growing Japonica rice. Adopting the higher-yielding, nutritious Japonica rice whose cultivation emits less GHG in these regions could help strengthen food security while reducing GHGs in global rice cultivation. | Uyeh, Daniel Dooyum; Asem-Hiablie, Senorpe; Park, Tusan; Kim, Kyungmin; Mikhaylov, Alexey; Woo, Seungmin; Ha, Yushin | Kyungpook Natl Univ, Dept Bioind Machinery Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Upland Field Machinery Res Ctr, Daegu 41566, South Korea; Kyungpook Natl Univ, Smart Agr Innovat Ctr, Daegu 41566, South Korea; Penn State Univ, Inst Energy & Environm, University Pk, PA 16802 USA; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Div Plant Biosci, Daegu 41566, South Korea; Minist Finance Russian Federat, Financial Res Inst, Moscow 127006, Russia | Park, Tusan/C-2057-2012; Mikhaylov, Alexey/A-7964-2015; Kim, Kyung-Min Kim/C-7007-2014 | 57194449611; 36656958300; 57202780408; 34868260300; 57214766800; 57192074884; 57192072314 | uyehdooyum@gmail.com;senorpe.ah@gmail.com;tusan.park@knu.ac.kr;kkm@knu.ac.kr;Alexeyfa@ya.ru;woosm7571@gmail.com;yushin72@knu.ac.kr; | FOODS | FOODS | 2304-8158 | 10 | 8 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 5.561 | 24.0 | 4.92 | 2025-07-30 | 15 | 54 | rice cultivation; rice carbon emissions; hidden hunger; parboiling; rice quality; rice preference | MILLED-RICE; GROWING-SEASON; QUALITY; DIFFERENTIATION; EMISSIONS; DOMESTICATION; HISTORY; METHANE; ORIGIN; UPLAND | Hidden hunger; Parboiling; Rice carbon emissions; Rice cultivation; Rice preference; Rice quality | English | 2021 | 2021-08 | 10.3390/foods10081869 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Ethanol-Induced Hepatotoxicity and Alcohol Metabolism Regulation by GABA-Enriched Fermented Smilax china Root Extract in Rats | Chronic alcohol consumption can cause hepatic injury and alcohol-induced toxicities. Extracts from Smilax china root have been widely used in traditional medicine and for their potential pharmacological benefits. We aimed to determine if fermented Smilax china extract (FSC) regulates alcoholic fatty liver and liver injury using two in vivo experiments. Sprague-Dawley rats were administered ethanol (3 g/kg b.w.; po) with or without FSC pretreatment to induce an acute hangover. In another experiment, rats were fed either a normal or Lieber-DeCarli ethanol (6.7%) diet with or without FSC pretreatment (125, 250, and 500 mg/kg b.w.; po) for 28 days. Serum biomarkers, liver histopathology, and the mRNA levels of anti-inflammatory, antioxidant, lipogenic, and lipolytic genes were analyzed. FSC pretreatment significantly reduced blood alcohol and acetaldehyde concentrations, upregulated the mRNA expression of alcohol dehydrogenase, aldehyde dehydrogenase, and superoxide dismutase, and decreased the activities of liver enzymes in a dose-dependent manner. It also downregulated SERBP-1c and upregulated PPAR-alpha and reduced the gene expression of the anti-inflammatory cytokine IL-6 in the liver. The final extract after fermentation had increased GABA content. Furthermore, FSC was found to be safe with no acute oral toxicity in female rats. Thus, FSC increases alcohol metabolism and exhibits antioxidant and anti-inflammatory effects to induce hepatoprotection against alcohol-induced damage. It may be used as a functional food ingredient after excess alcohol consumption. | Boby, Naila; Lee, Eon-Bee; Abbas, Muhammad Aleem; Park, Na-Hye; Lee, Sam-Pin; Ali, Md. Sekendar; Lee, Seung-Jin; Park, Seung-Chun | Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 41061, South Korea; Keimyung Univ, Dept Food Sci & Technol, Daegu 42601, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Brain Sci & Engn Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Brain Sci & Engn Inst, Daegu 41944, South Korea; Int Islamic Univ Chittagong, Dept Pharm, Chittagong 4318, Bangladesh; Korea Inst Toxicol, Dev & Reprod Toxicol Res Grp, Daejeon 34114, South Korea | ; Lee, Jun Young/CAI-2335-2022; Abbas, Muhammad Aleem/GLT-8362-2022; Lee, Jung Bok/HHZ-3200-2022; Boby, Naila/GRE-8096-2022; Park, Seung-Chun/AAV-3388-2021 | 57197787296; 57216526135; 57216531374; 57192425603; 57216647188; 57219661221; 58689440900; 7501832396 | nailaboby@knu.ac.kr;eonbee@gmail.com;syedaleemabbas77@gmail.com;skyphn@naver.com;splee@knu.ac.kr;alipharm2000@gmail.com;lee.seungjin@kitox.re.kre;parksch@knu.ac.kr; | FOODS | FOODS | 2304-8158 | 10 | 10 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 5.561 | 24.0 | 1.28 | 2025-07-30 | 16 | 17 | Smilax china; alcohol metabolism; superoxide dismutase; alcohol dehydrogenase; aldehyde dehydrogenase | IN-VITRO; ANTIOXIDANT ACTIVITY; L. LEAF; HANGOVER; NICOTINE; MICE | Alcohol dehydrogenase; Alcohol metabolism; Aldehyde dehydrogenase; Smilax china; Superoxide dismutase | English | 2021 | 2021-10 | 10.3390/foods10102381 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases | Fermented soybean products, such as cheonggukjang (Japanese natto), doenjang (soy paste), ganjang (soy sauce), and douchi, are widely consumed in East Asian countries and are major sources of bioactive compounds. The fermentation of cooked soybean with bacteria (Bacillus spp.) and fungi (Aspergillus spp. and Rhizopus spp.) produces a variety of novel compounds, most of which possess health benefits. This review is focused on the preventive and ameliorative potential of fermented soy foods and their components to manage neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. | Jang, Chan Ho; Oh, Jisun; Lim, Ji Sun; Kim, Hyo Jung; Kim, Jong-Sang | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Natl Inst Korean Med Dev, Dept Korean Med Dev, Gyongsan 38540, South Korea; Kyungpook Natl Univ, Dept Integrat Biotechnol, Daegu 41566, South Korea | 24477187500; 56311554100; 57202909530; 55673631100; 37106950100 | cksghwkd7@gmail.com;j.oh@knu.ac.kr;lzsunny@daum.net;indersee31@nikom.or.kr;vision@knu.ac.kr; | FOODS | FOODS | 2304-8158 | 10 | 3 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 5.561 | 24.0 | 2.3 | 2025-07-30 | 64 | 74 | fermented soybean products; Parkinson's disease; Alzheimer's disease; isoflavones; gut microbiota | LACTIC-ACID BACTERIA; CALORIC-RESTRICTION MIMETICS; GROUP-B SOYASAPONINS; ANTIOXIDANT ACTIVITIES; DOPAMINERGIC-NEURONS; ALZHEIMERS-DISEASE; GUT-MICROBIOTA; PARKINSONS-DISEASE; COGNITIVE FUNCTION; OXIDATIVE STRESS | Alzheimer’s disease; Fermented soybean products; Gut microbiota; Isoflavones; Parkinson’s disease | English | 2021 | 2021-03 | 10.3390/foods10030636 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Metabolomic Variability of Different Soybean Genotypes: β-Carotene-Enhanced (Glycine max), Wild (Glycine soja), and Hybrid (Glycine max x Glycine soja) Soybeans | We obtained a new hybrid soybean (Hybrid) by hybridizing beta-carotene-enhanced soybean (BCE; Glycine max L.) containing the phytoene synthase-2A-carotene desaturase gene and wild-type soybean (Wild; Glycine soja). To investigate metabolic changes between variants, we performed metabolic profiling of leaves (three growth stages) and seeds. Multivariate analyses revealed significant metabolic differences between genotypes in seeds and leaves, with seeds showing accumulation of phytosterols, tocopherols, and carotenoids (BCE only), indicating co-induction of the methylerythritol 4-phosphate and mevalonic acid pathways. Additionally, Hybrid produced intermediate levels of carotenoids and high levels of amino acids. Principal component analysis revealed metabolic discrimination between growth stages of soybean leaves and identified differences in leaf groups according to different genotypes at 8, 12, and 16 weeks, with Wild showing higher levels of environmental stress-related compounds relative to BCE and Hybrid leaves. The metabolic profiling approach could be a useful tool to identify metabolic links in various soybean cultivars. | Jung, Jung-Won; Park, Soo-Yun; Oh, Sung-Dug; Jang, Yejin; Suh, Sang-Jae; Park, Soon-Ki; Ha, Sun-Hwa; Park, Sang-Un; Kim, Jae-Kwang | Incheon Natl Univ, Div Life Sci, Incheon 22012, South Korea; Rural Dev Adm RDA, Natl Inst Agr Sci, Jeonju Si 55365, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Kyung Hee Univ, Dept Genet Engn, Yongin 17104, South Korea; Chungnam Natl Univ, Dept Crop Sci, Daehak Ro 99, Daejeon 34134, South Korea; Chungnam Natl Univ, Dept Smart Agr Syst, 99 Daehak Ro, Daejeon 34134, South Korea | 57314365300; 45661697500; 7404104129; 55612018200; 15754843200; 8055974900; 7202501231; 57783497100; 56892616700 | 19961015@inu.ac.kr;psy22@korea.kr;ohbaboh@korea.kr;jyejin@korea.kr;sjsuh@knu.ac.kr;psk@knu.ac.kr;sunhwa@khu.ac.kr;supark@cnu.ac.kr;kjkpj@inu.ac.kr; | FOODS | FOODS | 2304-8158 | 10 | 10 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 5.561 | 24.0 | 0.88 | 2025-07-30 | 12 | 13 | metabolic profiling; metabolite analysis; hybrid soybean; beta-carotene-enhanced soybean; wild soybean | GAMMA-AMINOBUTYRIC-ACID; GENETIC DIVERSITY; PHYTOSTEROL; ANTIOXIDANT; TURNOVER; PLANTS | Hybrid soybean; Metabolic profiling; Metabolite analysis; Wild soybean; β-carotene-enhanced soybean | English | 2021 | 2021-10 | 10.3390/foods10102421 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Protective Effect of Prunus mume Fermented with Mixed Lactic Acid Bacteria in Dextran Sodium Sulfate-Induced Colitis | The fruit of Prunus mume (PM) is widely cultivated in East Asia, and it has been used as a folk medication for gastrointestinal disorders, e.g., diarrhea, stomach ache and ulceration. In this study, the pectinase-treated PM juice (PJ) was fermented with Lactobacillus strains containing fundamental organic acids and free amino acids. The PJ fermented with Lactobacillus plantarum and L. casei (FP) was investigated for its protective effect in dextran sodium sulfate (DSS)-induced colitis mice model. The administration of FP reduced lipid peroxidation and histopathological colitis symptoms, e.g., shortening of the colon length, depletion of mucin, epithelial injury and ulceration, in colonic tissues. The FP-supplemented group showed the alleviation of pro-inflammatory cytokines. Compared with the DSS control group, the supplementation of FP significantly reduced the levels of serum interferon-gamma (IFN-gamma), interleukin (IL)-1 beta, IL-6, IL-12 and IL-17 as well as colonic tumor necrosis factor-alpha, IFN-gamma, IL-12 and IL-17. Furthermore, the DSS-induced TUNEL-positive area was significantly reduced by the FP supplementation. These results show that the supplementation of FP fermented with mixed lactic acid bacteria, L. plantarum and L. casei, elucidated the protective effect in DSS-induced colitis mice. Hence, this study suggests that FP can be utilized as a natural therapeutic agent for colitis and intestinal inflammation. | Kim, Jeong-Ho; Won, Yeong-Seon; Cho, Hyun-Dong; Hong, Seong-Min; Moon, Kwang-Deog; Seo, Kwon-Il | Kyungpook Natl Univ, Dept Food Sci & Technol, Daegu 41566, South Korea; Dong A Univ, Dept Food Biotechnol, Busan 49315, South Korea; Univ Illinois, Dept Pharmacol & Regenerat Med, Chicago, IL 60612 USA; Gachon Univ, Coll Pharm, Incheon 21936, South Korea; Gachon Univ, Gachon Inst Pharmaceut Sci, Incheon 21936, South Korea | Kim, Jeong-Ho/A-7641-2018; Cho, Hyun-Dong/HLW-0763-2023 | 57194659775; 59148009100; 55383853000; 57194647985; 55999192900; 59836699000 | kimjeoho90@gmail.com;wonys@dau.ac.kr;chd0811@hanmail.net;homsgm0517@gmail.com;kdmoon@knu.ac.kr;kseo@dau.ac.kr; | FOODS | FOODS | 2304-8158 | 10 | 1 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 5.561 | 24.0 | 1.47 | 2025-07-30 | 18 | 18 | colitis; fermentation; lactic acid bacteria; pro-inflammatory cytokine; Prunus mume | Colitis; Fermentation; Lactic acid bacteria; Pro-inflammatory cytokine; Prunus mume | English | 2021 | 2021-01 | 10.3390/foods10010058 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Facilitating Reparative Dentin Formation Using Apigenin Local Delivery in the Exposed Pulp Cavity | Apigenin, a natural product belonging to the flavone class, affects various cell physiologies, such as cell signaling, inflammation, proliferation, migration, and protease production. In this study, apigenin was applied to mouse molar pulp after mechanically pulpal exposure to examine the detailed function of apigenin in regulating pulpal inflammation and tertiary dentin formation. In vitro cell cultivation using human dental pulp stem cells (hDPSCs) and in vivo mice model experiments were employed to examine the effect of apigenin in the pulp and dentin regeneration. In vitro cultivation of hDPSCs with apigenin treatment upregulated bone morphogenetic protein (BMP)- and osteogenesis-related signaling molecules such as BMP2, BMP4, BMP7, bone sialoprotein (BSP), runt-related transcription factor 2 (RUNX2), and osteocalcin (OCN) after 14 days. After apigenin local delivery in the mice pulpal cavity, histology and cellular physiology, such as the modulation of inflammation and differentiation, were examined using histology and immunostainings. Apigenin-treated specimens showed period-altered immunolocalization patterns of tumor necrosis factor (TNF)-alpha, myeloperoxidase (MPO), NESTIN, and transforming growth factor (TGF)-beta 1 at 3 and 5 days. Moreover, the apigenin-treated group showed a facilitated dentin-bridge formation with few irregular tubules after 42 days from pulpal cavity preparation. Micro-CT images confirmed obvious dentin-bridge structures in the apigenin-treated specimens compared with the control. Apigenin facilitated the reparative dentin formation through the modulation of inflammation and the activation of signaling regulations. Therefore, apigenin would be a potential therapeutic agent for regenerating dentin in exposed pulp caused by dental caries and traumatic injury. | Aryal, Yam Prasad; Yeon, Chang-Yeol; Kim, Tae-Young; Lee, Eui-Seon; Sung, Shijin; Pokharel, Elina; Kim, Ji-Youn; Choi, So-Young; Yamamoto, Hitoshi; Sohn, Wern-Joo; Lee, Youngkyun; An, Seo-Young; An, Chang-Hyeon; Jung, Jae-Kwang; Ha, Jung-Hong; Kim, Jae-Young | Kyungpook Natl Univ, Sch Dent, Dept Biochem, IHBR, Daegu, South Korea; Gachon Univ, Dept Dent Hyg, Coll Hlth Sci, Incheon, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, IHBR, Daegu, South Korea; Tokyo Dent Coll, Dept Histol & Dev Biol, Tokyo, Japan; Daegu Haany Univ, Premajor Cosmet & Pharmaceut, Gyongsan, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Radiol, IHBR, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Med, IHBR, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Conservat Dent, IHBR, Daegu, South Korea | Kim, Ji-Youn/A-5779-2017 | 57202611163; 57211854259; 57208461628; 57202610354; 55787126100; 57220028220; 57157491000; 57202918688; 55725330600; 44161404800; 36062942200; 55258203200; 17134437600; 55970994400; 55549831900; 56812734700 | endoking@knu.ac.kr;jykim91@knu.ac.kr; | FRONTIERS IN PHYSIOLOGY | FRONT PHYSIOL | 1664-042X | 12 | SCIE | PHYSIOLOGY | 2021 | 4.755 | 24.1 | 0.82 | 2025-07-30 | 10 | 10 | inflammation; osteodentin; pulp cavity; reparative dentin formation; signaling modulation | WNT; INFLAMMATION; CELLS; DIFFERENTIATION; REGENERATION; STRESS; SIGNAL | inflammation; osteodentin; pulp cavity; reparative dentin formation; signaling modulation | apigenin; bone morphogenetic protein; bone morphogenetic protein 2; bone morphogenetic protein 4; bone sialoprotein; myeloperoxidase; nestin; osteocalcin; osteogenic protein 1; transcription factor RUNX2; transforming growth factor beta1; tumor necrosis factor; adult; animal cell; animal experiment; animal model; animal tissue; Article; bone development; cell differentiation; cell function; controlled study; dental caries; dental pulp cavity; dental pulp stem cell; dentin; histology; human; human cell; immunolocalization; in vitro study; inflammation; injury; male; micro-computed tomography; mouse; nonhuman; signal transduction; tooth pulp disease; upregulation | English | 2021 | 2021-12-10 | 10.3389/fphys.2021.773878 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Protective Effects of Complement Component 8 Gamma Against Blood-Brain Barrier Breakdown | The blood-brain barrier (BBB) regulates the traffic of micromolecules and macromolecules between the peripheral blood and the central nervous system, to maintain brain homeostasis. BBB disruption and dysfunction accompany a variety of neurological disorders and are closely related with the neuroinflammatory cascades that are triggered by leukocyte infiltration and glial activation. Here, we explored the role of complement component 8 gamma (C8G) in the maintenance of BBB integrity. Previously, C8G was shown to inhibit neuroinflammation by interfering with the sphingosine-1-phosphate (S1P)-S1PR2 interaction. The results of the present study revealed that C8G is localized in perivascular astrocytes, whereas S1PR2 is expressed in endothelial cells (ECs). In the lipopolysaccharide (LPS)-induced neuroinflammation model, the intracerebroventricular administration of the recombinant C8G protein protected the integrity of the BBB, whereas shRNA-mediated C8G knockdown enhanced BBB permeability and neutrophil infiltration. Using pharmacological agonists and antagonists of S1PR2, we demonstrated that C8G inhibited the inflammatory activation of ECs in culture by antagonizing S1PR2. In the in vitro BBB model, the addition of the recombinant C8G protein preserved endothelial integrity, whereas the knockdown of C8G exacerbated endothelial leakage under inflammatory conditions. Together, our findings indicate an important role for astrocytic C8G in protecting the BBB in the inflamed brain, suggesting a novel mechanism of cross talk between astrocytes and ECs in terms of BBB maintenance. | Kim, Jong-Heon; Han, Jin; Suk, Kyoungho | Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Daegu, South Korea | 57203324811; 57218360938; 7005114595 | jongheonkim@knu.ac.kr;ksuk@knu.ac.kr; | FRONTIERS IN PHYSIOLOGY | FRONT PHYSIOL | 1664-042X | 12 | SCIE | PHYSIOLOGY | 2021 | 4.755 | 24.1 | 0.9 | 2025-07-30 | 13 | 13 | complement component 8 gamma; sphingosine-1-phosphate; sphingosine-1-phosphate receptor 2; blood-brain barrier; astrocyte; neuroinflammation | ASTROCYTE-ENDOTHELIAL INTERACTIONS; SPHINGOSINE KINASE; SPHINGOSINE-1-PHOSPHATE RECEPTOR-2; SPHINGOLIPID METABOLISM; VASCULAR-PERMEABILITY; ACTIVATION; CELLS; LIPOPOLYSACCHARIDE; DISRUPTION; EXPRESSION | astrocyte; blood-brain barrier; complement component 8 gamma; neuroinflammation; sphingosine-1-phosphate; sphingosine-1-phosphate receptor 2 | 3 (4 methylphenylsulfonyl) 2 propenenitrile; complement component 8 gamma; complement component C8; Evans blue; interleukin 1beta; interleukin 6; lysosphingolipid receptor; nitrite; short hairpin RNA; sphingosine 1 phosphate receptor; sphingosine 2 phosphate receptor; unclassified drug; animal cell; animal experiment; animal model; animal tissue; Article; astrocyte; bEnd.3 cell line; blood brain barrier; blood brain barrier integrity; cell membrane permeability; cell viability assay; controlled study; down regulation; electric resistance; endothelial cell line; enzyme activation; extravasation; gene silencing; HEK293T cell line; HUVEC cell line; immunofluorescence; immunohistochemistry; in vitro study; lipopolysaccharide-induced neuroinflammation; male; mouse; MTT assay; nervous system parameters; neuroprotection; neutrophil chemotaxis; nonhuman; nucleotide sequence; polyacrylamide gel electrophoresis; protein expression; reverse transcription polymerase chain reaction; transendothelial electric resistance; upregulation | English | 2021 | 2021-06-03 | 10.3389/fphys.2021.671250 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Salicylic Acid, a Plant Hormone, Suppresses Phytophagous Insect Immune Response by Interrupting HMG-Like DSP1 | Salicylic acid is a plant hormone that can mediate various plant physiological processes. Salicylic acid can bind to human high mobility group box 1 (HMGB1) and interrupt its role in mediating immune responses. Dorsal switch protein 1 (DSP1) is an insect homolog of HMGB1. In this study, a DSP1 (Se-DSP1) encoded in Spodoptera exigua, a phytophagous insect, was characterized, and its potential role in immune response was explored. Upon bacterial challenge, Se-DSP1 was localized in the nucleus and released into the hemolymph. The released Se-DSP1 could mediate both cellular and humoral immune responses by activating eicosanoid biosynthesis. Salicylic acid could bind to Se-DSP1 with a high affinity. The immune responses of S. exigua were significantly interrupted by SA feeding. Larvae reared on tomatoes with high endogenous SA levels became more susceptible to entomopathogens. Taken together, these results suggest a tritrophic defensive role of plant SA against phytophagous insects. | Mollah, Md Mahi Imam; Choi, Hyong Woo; Yeam, Inhwa; Lee, Je Min; Kim, Yonggyun | Andong Natl Univ, Dept Plant Med, Andong, South Korea; Andong Natl Univ, Dept Hort & Breeding, Andong, South Korea; Kyungpook Natl Univ, Dept Hort Sci, Daegu, South Korea | Mollah, Md Mahi Imam/HPD-8829-2023; Choi, Hyong/W-7213-2019; Lee, Je/AAE-7496-2020; Lee, Je Min/F-9797-2014 | 57210188026; 14627068300; 9733885400; 8885729900; 59662780600 | hosanna@anu.ac.kr; | FRONTIERS IN PHYSIOLOGY | FRONT PHYSIOL | 1664-042X | 12 | SCIE | PHYSIOLOGY | 2021 | 4.755 | 24.1 | 1.81 | 2025-07-30 | 25 | 25 | salicylic acid; eicosanoid; HMGB1; immunity; insect | GROUP BOX 1; DNA-BINDING; TRANSCRIPTIONAL ACTIVITY; DROSOPHILA DSP1; PROTEIN; MEDIATOR; RELEASE; TOLL; INFLAMMATION; ACTIVATION | eicosanoid; HMGB1; immunity; insect; salicylic acid | dorsal switch protein 1; high mobility group B protein; salicylic acid; unclassified drug; animal tissue; Article; binding affinity; biosynthesis; controlled study; DSP1 gene; hemolymph; immune response; insect; insect larva; nonhuman; plant pest; Spodoptera exigua | English | 2021 | 2021-10-04 | 10.3389/fphys.2021.744272 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Antibacterial Activity of LCB10-0200 against Klebsiella pneumoniae | Klebsiella pneumoniae is one of the important clinical organisms that causes various infectious diseases, including urinary tract infections, necrotizing pneumonia, and surgical wound infections. The increase in the incidence of multidrug-resistance K. pneumoniae is a major problem in public healthcare. Therefore, a novel antibacterial agent is needed to treat this pathogen. Here, we studied the in vitro and in vivo activities of a novel antibiotic LCB10-0200, a siderophore-conjugated cephalosporin, against clinical isolates of K. pneumoniae. In vitro susceptibility study found that LCB10-0200 showed potent antibacterial activity against K. pneumoniae, including the beta-lactamase producing strains. The in vivo efficacy of LCB10-0200 was examined in three different mouse infection models, including systemic, thigh, and urinary tract infections. LCB10-0200 showed more potent in vivo activity than ceftazidime in the three in vivo models against the drug-susceptible and drug-resistant K. pneumoniae strains. Taken together, these results show that LCB10-0200 is a potential antibacterial agent to treat infection caused by K. pneumoniae. | Oh, Sang-Hun; Kim, Young-Rok; Park, Hee-Soo; Oh, Kyu-Man; Cho, Young-Lag; Kwak, Jin-Hwan | Handong Global Univ, Sch Life Sci, Pohang 37554, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; LegoChem Biosci Inc, Daejeon 34302, South Korea | Kim, Hae-Yeong/S-1685-2017; Park, Hee-Soo/AAC-6422-2019; Kwak, Jin-Hwan/AAI-1895-2020 | 57192113352; 57208315805; 15751448400; 57201249126; 56308025500; 34975548100 | shoh@handong.edu;fred87@nate.com;phsoo97@knu.ac.kr;kyuman@legochembio.com;young@legochembio.com;jhkwak@handong.edu; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 10 | 10 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2021 | 5.222 | 24.2 | 0.09 | 2025-07-30 | 2 | 2 | Klebsiella pneumoniae; siderophore; cephalosporin | SPECTRUM BETA-LACTAMASES; ANTIBIOTIC-RESISTANCE; SIDEROPHORE CEPHALOSPORIN; PSEUDOMONAS-AERUGINOSA; MECHANISMS; INFECTION | Cephalosporin; Klebsiella pneumoniae; LCB10-0200; Siderophore | antibiotic agent; cephalosporin; lcb10 0200; siderophore; stomach mucin; unclassified drug; animal experiment; animal model; antibacterial activity; antibiotic resistance; antibiotic sensitivity; Article; bacterial growth; bacterial load; bacterial strain; bacterium isolate; colony forming unit; controlled study; in vitro study; Klebsiella pneumoniae; male; minimum inhibitory concentration; mortality; mouse; necrotizing pneumonia; nonhuman; pneumonia; Pseudomonas aeruginosa; surgical infection; urinary tract infection; wound infection | English | 2021 | 2021-10 | 10.3390/antibiotics10101185 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | DksA Modulates Antimicrobial Susceptibility of Acinetobacter baumannii | The stringent response regulators, (p)ppGpp and DksA, modulate various genes involved in physiological processes, virulence, and antimicrobial resistance in pathogenic bacteria. This study investigated the role of DksA in the antimicrobial susceptibility of Acinetobacter baumannii. The increment dksA mutant (KM0248D) of A. baumannii ATCC 17978 and its complemented strain (KM0248C) were used, in addition to the increment dksA mutant strain (NY0298D) of clinical 1656-2 strain. The microdilution assay was used to determine the minimum inhibitory concentrations (MICs) of antimicrobial agents. Quantitative real-time PCR was performed to analyze the expression of genes associated with efflux pumps. The KM0248D strain exhibited an increase of MICs to quinolones and tetracyclines, whereas KM0248D and NY0298D strains exhibited a decrease of MICs to aminoglycosides. The expression of genes associated with efflux pumps, including adeB, adeI/J, abeM, and/or tetA, was upregulated in both increment dksA mutant strains. The deletion of dksA altered bacterial morphology in the clinical 1656-2 strain. In conclusion, DksA modulates the antimicrobial susceptibility of A. baumannii. The increment dksA mutant strains of A. baumannii upregulate efflux pump gene expression, whereas (p)ppGpp-deficient mutants downregulate efflux pump gene expression. (p)ppGpp and DksA conduct opposite roles in the antimicrobial susceptibility of A. baumannii via efflux pump gene regulation. | Kim, Nayeong; Son, Joo-Hee; Kim, Kyeongmin; Kim, Hyo-Jeong; Shin, Minsang; Lee, Je-Chul | Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu 41944, South Korea | 57211500281; 57201721443; 57216604095; 57221772924; 7401536650; 25930392000 | tbc02021@naver.com;soun716@daum.net;horizon112@naver.com;lo0729ve@naver.com;shinms@knu.ac.kr;leejc@knu.ac.kr; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 10 | 12 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2021 | 5.222 | 24.2 | 0.19 | 2025-07-30 | 5 | 5 | Acinetobacter baumannii; DksA; (p)ppGpp; antimicrobial susceptibility; efflux pump gene | RESISTANCE; PPGPP; GENES; PROMOTERS; OMPA; COLI | (p)ppGpp; Acinetobacter baumannii; Antimicrobial susceptibility; DksA; Efflux pump gene | amikacin; bacterial protein; cefotaxime; cefoxitin; ceftazidime; chloramphenicol; ciprofloxacin; colistin; DksA protein; erythromycin; gentamicin; imipenem; levofloxacin; meropenem; nalidixic acid; tetracycline derivative; tigecycline; tobramycin; trimethoprim; unclassified drug; abeM gene; Acinetobacter baumannii; adeB gene; adeI gene; adeJ gene; antibiotic sensitivity; Article; cell heterogeneity; controlled study; down regulation; Escherichia coli; gene; gene deletion; gene expression; Gram staining; minimum inhibitory concentration; nonhuman; real time polymerase chain reaction; upregulation | English | 2021 | 2021-12 | 10.3390/antibiotics10121472 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Fluoroquinolone Can Be an Effective Treatment Option for Acute Pyelonephritis When the Minimum Inhibitory Concentration of Levofloxacin for the Causative Escherichia coli Is ≤16 mg/L | The purpose of this study was to determine whether the fluoroquinolone (FQ) minimum inhibitory concentration (MIC) for the causative agent Escherichia coli influences the clinical response of FQ treatment at 72 h in patients with community-acquired acute pyelonephritis (CA-APN). We prospectively collected the clinical data of women with CA-APN from 11 university hospitals from March 2010 to February 2012 as well as E. coli isolates from the urine or blood. In total, 78 patients included in this study received FQ during the initial 72 h, and the causative E. coli was detected. The clinical response at 72 h was significantly higher in patients with a levofloxacin MIC 16 mg/L (70.4% vs. 28.6%, p = 0.038). No difference was observed in clinical response at 72 h based on ciprofloxacin MIC. To summarize, FQ can be an effective treatment option for CA-APN when levofloxacin MIC against E. coli is <= 16 mg/L. | Kim, Yeonjae; Kim, Bongyoung; Wie, Seong Heon; Kim, Jieun; Ki, Moran; Cho, Yong Kyun; Lim, Seung Kwan; Lee, Jin Seo; Kwon, Ki Tae; Lee, Hyuck; Cheong, Hee Jin; Park, Dae Won; Ryu, Seong Yeol; Chung, Moon Hyun; Pai, Hyunjoo | Natl Med Ctr, Ctr Infect Dis, Seoul 04564, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul 04763, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Div Infect Dis,St Vincents Hosp, Seoul 06591, South Korea; Natl Canc Ctr, Grad Sch Canc Sci & Policy, Dept Canc Control & Policy, Goyang 10408, South Korea; Gacheon Univ, Med Coll, Dept Internal Med, Incheon 21565, South Korea; Gyeonggi Prov Med Ctr, Ansung Hosp, Dept Internal Med, Ansung 17572, South Korea; Hallym Univ, Kangdong Sacred Heart Hosp, Div Infect Dis, Seoul 05355, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41566, South Korea; Dong A Univ, Dong A Univ Hosp, Div Infect Dis, Busan 49201, South Korea; Korea Univ, Guro Hosp, Div Infect Dis, Seoul 08308, South Korea; Korea Univ, Ansan Hosp, Div Infect Dis, Ansan 15355, South Korea; Keimyeong Univ, Dongsan Hosptial, Div Infect Dis, Daegu 41931, South Korea; Seogwipo Med Ctr, Div Infect Dis, Jeju 63585, South Korea | ; Kim, Ji/J-5440-2012; Kim, Woo/AAG-1822-2019; Pai, Hyunjoo/M-7492-2018; Kim, Hyunho/GQH-5608-2022; Ki, Moran/R-6600-2019; Kim, Bongyoung/H-3409-2018; Kim, Hanjin/KYP-2633-2024 | 56066688300; 55622077200; 12796392700; 51963871600; 6603678673; 57222306801; 8042072100; 27171254600; 9733850500; 35076225200; 7102495865; 55724785200; 9733513600; 7402437198; 7004631730 | arckyj@nmc.or.kr;sobakas@hanyang.ac.kr;wiesh@catholic.ac.kr;quidam76@hanyang.ac.kr;moranki@ncc.re.kr;karmacho@gmail.com;haveabigheart@gmail.com;rem324@naver.com;ktkwon@knu.ac.kr;hyucklee@gmail.com;heejinmd@korea.ac.kr;pugae1@hanmail.net;121rsy@hanmail.net;mhchungid@daum.net;paihj@hanyang.ac.kr; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 10 | 1 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2021 | 5.222 | 24.2 | 0.38 | 2025-07-30 | 3 | 5 | urinary tract infection; pyelonephritis; E; coli; fluoroquinolone; treatment | URINARY BACTERICIDAL ACTIVITY; ANTIBIOTIC-TREATMENT; CLINICAL FAILURE; RESISTANCE | E. coli; Fluoroquinolone; Pyelonephritis; Treatment; Urinary tract infection | antibiotic agent; levofloxacin; quinolone derivative; acute pyelonephritis; adult; antibiotic resistance; antibiotic sensitivity; Article; Charlson Comorbidity Index; cohort analysis; controlled study; diabetes mellitus; Escherichia coli; female; fever; hospitalization; human; leukocyte count; leukocytosis; major clinical study; male; middle aged; minimum inhibitory concentration; nonhuman; observational study; prospective study; pyelonephritis; pyuria; urinary tract infection; urine culture | English | 2021 | 2021-01 | 10.3390/antibiotics10010037 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Improving Surface Imprinting Effect by Reducing Nonspecific Adsorption on Non-Imprinted Polymer Films for 2,4-D Herbicide Sensors | Surface imprinting used for template recognition in nanocavities can be controlled and improved by surface morphological changes. Generally, the lithographic technique is used for surface patterning concerning sensing signal amplification in molecularly imprinted polymer (MIP) thin films. In this paper, we describe the effects of silanized silica molds on sensing the properties of MIP films. Porous imprinted poly(MAA-co-EGDMA) films were lithographically fabricated using silanized or non-treated normal silica replica molds to detect 2,4-dichlorophenoxyacetic acid (2,4-D) herbicide as the standard template. The silanized mold MIP film (st-MIP) (Delta f = -1021 Hz) exhibited a better sensing response than the non-treated normal MIP (n-MIP) (Delta f = -978 Hz) because the imprinting effects, which occurred via functional groups on the silica surface, could be reduced through silane modification. Particularly, two non-imprinted (NIP) films (st-NIP and n-NIP) exhibited significantly different sensing responses. The st-NIP (Delta f(st-NIP) = -332 Hz) films exhibited lower Delta f values than the n-NIP film (Delta f(n-NIP) = -610 Hz) owing to the remarkably reduced functionality against nonspecific adsorption. This phenomenon led to different imprinting factor (IF) values for the two MIP films (IFst-MIP = 3.38 and IFn-MIP = 1.86), which was calculated from the adsorbed 2,4-D mass per poly(MAA-co-EGDMA) unit weight (i.e., Q(MIP)/Q(NIP)). Moreover, it was found that the st-MIP film had better selectivity than the n-MIP film based on the sensing response of analogous herbicide solutions. As a result, it was revealed that the patterned molds' chemical surface modification, which controls the surface functionality of imprinted films during photopolymerization, plays a role in fabricating enhanced sensing properties in patterned MIP films. | Yang, Jin Chul; Hong, Suck Won; Park, Jinyoung | Kyungpook Natl Univ, Sch Appl Chem Engn, 80 Daehak Ro, Daegu 41566, South Korea; Pusan Natl Univ, Dept Cognomechatron Engn, Dept Opt & Mechatron Engn, Coll Nanosci & Nanotechnol, Busan 46241, South Korea; Kyungpook Natl Univ, Dept Polymer Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea | ; PARK, JUN-YOUNG/P-5981-2015 | 56381794400; 57252820400; 57286293400 | whdns861223@knu.ac.kr;swhong@pusan.ac.kr;jinpark@knu.ac.kr; | CHEMOSENSORS | CHEMOSENSORS | 2227-9040 | 9 | 3 | SCIE | CHEMISTRY, ANALYTICAL;ELECTROCHEMISTRY;INSTRUMENTS & INSTRUMENTATION | 2021 | 4.229 | 24.2 | 0.58 | 2025-07-30 | 7 | 8 | molecular imprinting; photopolymerization; silanization; hemispherical silica mold; herbicide | Hemispherical silica mold; Herbicide; Molecular imprinting; Photopolymerization; Silanization | Ionomers; Lithography; Photopolymerization; Surface chemistry; Hemispherical silica mold; Imprinting effects; Imprinting factor; Molecular imprinting; Molecularly Imprinted Polymer; Molecularly imprinted polymer films; Photo polymerization; Sensing response; Silanizations; Surface imprinting; Herbicides | English | 2021 | 2021-03 | 10.3390/chemosensors9030043 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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