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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Therapeutic Potential of AAV1-Rheb(S16H) Transduction against Neurodegenerative Diseases | Neurotrophic factors (NTFs) are essential for cell growth, survival, synaptic plasticity, and maintenance of specific neuronal population in the central nervous system. Multiple studies have demonstrated that alterations in the levels and activities of NTFs are related to the pathology and symptoms of neurodegenerative disorders, such as Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease. Hence, the key molecule that can regulate the expression of NTFs is an important target for gene therapy coupling adeno-associated virus vector (AAV) gene. We have previously reported that the Ras homolog protein enriched in brain (Rheb)-mammalian target of rapamycin complex 1 (mTORC1) axis plays a vital role in preventing neuronal death in the brain of AD and PD patients. AAV transduction using a constitutively active form of Rheb exerts a neuroprotective effect through the upregulation of NTFs, thereby promoting the neurotrophic interaction between astrocytes and neurons in AD conditions. These findings suggest the role of Rheb as an important regulator of the regulatory system of NTFs to treat neurodegenerative diseases. In this review, we present an overview of the role of Rheb in neurodegenerative diseases and summarize the therapeutic potential of AAV serotype 1 (AAV1)-Rheb(S16H) transduction in the treatment of neurodegenerative disorders, focusing on diseases, such as AD and PD. | Nam, Youngpyo; Moon, Gyeong Joon; Kim, Sang Ryong | Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41944, South Korea; Asan Med Ctr, Asan Inst Life Sci, Ctr Cell Therapy, Seoul 05505, South Korea; Univ Ulsan, Coll Med, Dept Convergence Med, Seoul 05505, South Korea; Kyungpook Natl Univ, Sch Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea | ; Moon, Gyeong/P-7878-2019 | 55143100300; 8323365700; 56486163800 | blackpyo2@naver.com;gj.moon@amc.seoul.kr;srk75@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 22 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 6.208 | 23.1 | 0.12 | 2025-07-30 | 6 | 5 | neurotrophic factor; Rheb(S16H); neurodegenerative disease; Alzheimer’ s disease; Parkinson’ s disease | NEUROTROPHIC-FACTOR; PARKINSONS-DISEASE; DOPAMINERGIC-NEURONS; SUBSTANTIA-NIGRA; MAMMALIAN TARGET; ALPHA-SYNUCLEIN; MOTOR-NEURONS; ALZHEIMER-DISEASE; RHEB GTPASE; MOUSE MODEL | Alzheimer’s disease; Neurodegenerative disease; Neurotrophic factor; Parkinson’s disease; Rheb(S16H) | Animals; Humans; Models, Biological; Nerve Growth Factors; Neurodegenerative Diseases; Parvovirinae; Ras Homolog Enriched in Brain Protein; Transduction, Genetic; adeno associated virus vector; mammalian target of rapamycin complex 1; neurotrophic factor; Rheb protein; nerve growth factor; Rheb protein; Adeno associated virus 1; Alzheimer disease; genetic transduction; human; mTOR signaling; neuroprotection; nonhuman; Parkinson disease; Review; viral gene delivery system; viral gene therapy; animal; biological model; degenerative disease; genetic transduction; metabolism; Parvovirinae | English | 2021 | 2021-03 | 10.3390/ijms22063064 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Transcription Factors as the "Blitzkrieg" of Plant Defense: A Pragmatic View of Nitric Oxide's Role in Gene Regulation | Plants are in continuous conflict with the environmental constraints and their sessile nature demands a fine-tuned, well-designed defense mechanism that can cope with a multitude of biotic and abiotic assaults. Therefore, plants have developed innate immunity, R-gene-mediated resistance, and systemic acquired resistance to ensure their survival. Transcription factors (TFs) are among the most important genetic components for the regulation of gene expression and several other biological processes. They bind to specific sequences in the DNA called transcription factor binding sites (TFBSs) that are present in the regulatory regions of genes. Depending on the environmental conditions, TFs can either enhance or suppress transcriptional processes. In the last couple of decades, nitric oxide (NO) emerged as a crucial molecule for signaling and regulating biological processes. Here, we have overviewed the plant defense system, the role of TFs in mediating the defense response, and that how NO can manipulate transcriptional changes including direct post-translational modifications of TFs. We also propose that NO might regulate gene expression by regulating the recruitment of RNA polymerase during transcription. | Falak, Noreen; Imran, Qari Muhammad; Hussain, Adil; Yun, Byung-Wook | Kyungpook Natl Univ, Sch Appl Biosci, Lab Plant Funct Genom, Daegu 702701, South Korea; Umea Univ, Dept Med Biochem & Biophys, S-90187 Umea, Sweden; Abdul Wali Khan Univ, Dept Agr, Mardan 23200, Khyber Pakhtunk, Pakistan | Hussain, Dr. Adil/K-6016-2018; Imran, Qari Muhammad/ABG-6074-2022; Hussain, Adil/K-6016-2018 | 57188737693; 55849263700; 41961162600; 8245123600 | noorfalak.pk@gmail.com;mimranbot@gmail.com;adilhussain@awkum.edu.pk;bwyun@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 22 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 6.208 | 23.1 | 1.01 | 2025-07-30 | 29 | 40 | nitric oxide; transcription factors; gene regulation; plant defense; guard hypothesis | PROGRAMMED CELL-DEATH; PATHOGEN RESISTANCE RESPONSE; AVIAN-MYELOBLASTOSIS VIRUS; ABIOTIC STRESS RESPONSES; S-NITROSYLATED PROTEINS; GENOME-WIDE ANALYSIS; ARABIDOPSIS-THALIANA; DNA-BINDING; SALICYLIC-ACID; COMPREHENSIVE ANALYSIS | Gene regulation; Guard hypothesis; Nitric oxide; Plant defense; Transcription factors | Disease Resistance; DNA-Directed RNA Polymerases; Gene Expression Regulation, Plant; Nitric Oxide; Plant Diseases; Transcription Factors; Transcription, Genetic; basic helix loop helix transcription factor; nitric oxide; protein Myb; RNA polymerase; transcription factor; transcription factor ap2; transcription factor nac; transcription factor wrky; unclassified drug; DNA directed RNA polymerase; nitric oxide; transcription factor; defense mechanism; gene control; gene expression; nonhuman; plant defense; protein processing; Review; synthesis; disease resistance; gene expression regulation; genetic transcription; genetics; metabolism; plant disease | English | 2021 | 2021-01 | 10.3390/ijms22020522 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Tunicamycin as a Novel Redifferentiation Agent in Radioiodine Therapy for Anaplastic Thyroid Cancer | The silencing of thyroid-related genes presents difficulties in radioiodine therapy for anaplastic thyroid cancers (ATCs). Tunicamycin (TM), an N-linked glycosylation inhibitor, is an anticancer drug. Herein, we investigated TM-induced restoration of responsiveness to radioiodine therapy in radioiodine refractory ATCs. I-125 uptake increased in TM-treated ATC cell lines, including BHT101 and CAL62, which was inhibited by KClO4, a sodium-iodide symporter (NIS) inhibitor. TM upregulated the mRNA expression of iodide-handling genes and the protein expression of NIS. TM blocked pERK1/2 phosphorylation in both cell lines, but AKT (protein kinase B) phosphorylation was only observed in CAL62 cells. The downregulation of glucose transporter 1 protein was confirmed in TM-treated cells, with a significant reduction in F-18-fluorodeoxyglucose (FDG) uptake. A significant reduction in colony-forming ability and marked tumor growth inhibition were observed in the combination group. TM was revealed to possess a novel function as a redifferentiation inducer in ATC as it induces the restoration of iodide-handling gene expression and radioiodine avidity, thereby facilitating effective radioiodine therapy. | Choi, Yoon Ju; Lee, Jae-Eon; Ji, Hyun Dong; Lee, Bo-Ra; Lee, Sang Bong; Kim, Kil Soo; Lee, In-Kyu; Chin, Jungwook; Cho, Sung Jin; Lee, Jaetae; Lee, Sang-Woo; Ha, Jeoung-Hee; Jeon, Yong Hyun | Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41566, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 41404, South Korea; Gyeongbuk Inst Bioind, Vaccine Commerializat Ctr, 88,Saneodanjigil, Andong Si 36618, Gyeongbuk, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41405, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu 41404, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu 41404, South Korea | Lee, Sang/I-8954-2014; Jeon, Yong/N-6910-2019; Kim, Seung/N-5248-2019; Lee, In-Kyu/AAR-6374-2021; Chin, Jungwook/E-7611-2013; lee, sangwoo/KUD-1906-2024; Lee, Jaetae/AAR-3317-2021 | 57214147987; 56808832000; 57191592819; 59602302100; 57190304501; 35272034300; 36071537600; 36554007700; 58735369700; 7601451907; 57196249819; 35073968600; 16042453400 | hongsi1221@naver.com;jaetae@knu.ac.kr;jihd0210@naver.com;damsmom@dgmif.re.kr;sangbongyi1@gmail.com;kslac@dgmif.re.kr;leei@knu.ac.kr;jwchin@dgmif.re.kr;sjcho@dgmif.re.kr;swleenm@knu.ac.kr;jhha4834@knu.ac.kr;jeon9014@gmail.com; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 22 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 6.208 | 23.1 | 0.44 | 2025-07-30 | 8 | 8 | tunicamycin; sodium-iodide symporter; anaplastic thyroid cancer; redifferentiation; radioiodine therapy | IODIDE SYMPORTER EXPRESSION; GLUCOSE TRANSPORTERS; CARCINOMA; INHIBITION; SORAFENIB; MIGRATION; PATHWAY | Anaplastic thyroid cancer; Radioiodine therapy; Redifferentiation; Sodium-iodide symporter; Tunicamycin | Animals; Antineoplastic Agents; Cell Differentiation; Cell Line, Tumor; Female; Fluorodeoxyglucose F18; Gene Silencing; Glycosylation; Humans; Iodides; Iodine Radioisotopes; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Phosphorylation; Proto-Oncogene Proteins c-akt; Symporters; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Tunicamycin; B Raf kinase; fluorodeoxyglucose f 18; glucose transporter 1; iodine 131; K ras protein; messenger RNA; mitogen activated protein kinase 1; mitogen activated protein kinase 3; potassium perchlorate; protein kinase B; radioactive iodine; tunicamycin; antineoplastic agent; cotransporter; iodide; Iodine-125; protein kinase B; radioactive iodine; sodium iodide symporter; tunicamycin; anaplastic thyroid carcinoma; animal experiment; Article; BHT-101 cell line; CAL-62 cell line; cancer inhibition; colony forming unit; combination drug therapy; controlled study; female; gene expression; human; human cell; in vitro study; in vivo study; mouse; mRNA expression level; nonhuman; protein expression; protein phosphorylation; radioisotope therapy; signal transduction; single drug dose; upregulation; uptake assay; animal; Bagg albino mouse; cancer transplantation; cell differentiation; chemistry; drug effect; gene silencing; glycosylation; MAPK signaling; metabolism; nude mouse; phosphorylation; thyroid carcinoma; thyroid tumor; tumor cell line | English | 2021 | 2021-02 | 10.3390/ijms22031077 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | An initial experience with a novel technique of single-port robotic resection for rectal cancer | Background The da Vinci single-port (SP) system is designed to facilitate single-incision robotic surgery in a narrow space. We developed a new procedure of rectal resection using this system. The aim of the present study was to evaluate the technical feasibility and safety of SP robotic rectal resection for rectal cancer patients based on our initial experience. Methods A study was conducted on consecutive patients with mid or low rectal cancer who had SP robotic resection at our institution between July and September 2020. The demographic characteristics, perioperative data, and pathology results of the patients were retrospectively analyzed. Results There were 5 patients (3 males, 2 females, median age 57 years (range 36-73 years). The median tumor height from the anal verge was 4 cm (range 3-5 cm). Two patients received preoperative chemoradiotherapy for advanced rectal cancer. A single docking was conducted, and the median docking time was 4 min 20 s (range 3 min 30 s to 5 min). The median total operation time was 195 min (range 155-240 min), and the median time of pelvic dissection was 45 min (range 36-62 min). All patients had circumferential and distal tumor-free resection margins. One patient experienced an anastomosis-related complication. The median duration of hospital stay was 7 days (range 7-8 days). Conclusions Our initial experience suggests that SP robotic rectal resection is safe and feasible. Further clinical trials comparing SP and multiport robotic rectal resection should be conducted to verify the superior aspects of this new system. | Kim, H. J.; Choi, G. -S.; Song, S. H.; Park, J. S.; Park, S. Y.; Lee, S. M.; Choi, J. A. | Kyungpook Natl Univ, Colorectal Canc Ctr, Chilgok Hosp, Sch Med, Daegu 41404, South Korea | 57204567554; 8058759100; 57221771693; 35226761100; 12242293700; 55236751200; 8692733000 | kyuschoi@mail.knu.ac.kr; | TECHNIQUES IN COLOPROCTOLOGY | TECH COLOPROCTOL | 1123-6337 | 1128-045X | 25 | 7 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;SURGERY | 2021 | 3.699 | 23.2 | 3.29 | 2025-07-30 | 30 | 28 | Robotic surgery; Single-port (SP) robot; Single-port (SP) robotic rectal resection; Rectal cancer | TOTAL MESORECTAL EXCISION; LAPAROSCOPIC SURGERY; LEARNING-CURVE; COLECTOMY; DISEASE | Rectal cancer; Robotic surgery; Single-port (SP) robot; Single-port (SP) robotic rectal resection | Adult; Aged; Female; Humans; Laparoscopy; Male; Middle Aged; Proctectomy; Rectal Neoplasms; Retrospective Studies; Robotic Surgical Procedures; Robotics; Treatment Outcome; antineoplastic agent; adult; advanced cancer; aged; Article; cancer patient; chemoradiotherapy; clinical article; end to end anastomosis; feasibility study; female; human; length of stay; male; middle aged; operation duration; operative blood loss; patient safety; postoperative complication; preoperative care; rectum anastomosis; rectum cancer; rectum resection; reoperation; retrospective study; robot assisted surgery; surgical margin; surgical technique; total mesorectal excision; treatment outcome; tumor volume; venous congestion; laparoscopy; rectum tumor; robotics | English | 2021 | 2021-07 | 10.1007/s10151-021-02457-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Initial experience with a suprapubic single-port robotic right hemicolectomy in patients with colon cancer | Background We developed a novel suprapubic single-port robotic right hemicolectomy (spRHC) procedure for patients with right colon cancer using a da Vinci SP Surgical System. The aim of this study was to determine the safety and feasibility of this technique. Methods We performed the spRHC procedure on five patients with right colon cancers between July and September 2020. All procedures including colon mobilization, D3 lymphadenectomy, and intracorporeal anastomosis were completed using the single-port robotic platform through a mini-transverse suprapubic incision and an additional assistant port. Data regarding patient characteristics, perioperative outcomes and pathologic results were analyzed. Results Four of the five patients were males. The median age was 69 years (range, 58-77 years).Two patients received preoperative chemotherapy for advanced colon cancer. The median total operative time was 160 min (range, 150-240 min). The median docking time was 4 min 40 s (range, 2 min 10 s-5 min 10 s). The median console time was 105 min (range, 100-120 min). There were no conversions to multiport or open surgeries. The median hospital stay was 7 days (range, 5-12 days). One patient experienced a wound infection. The median number of harvested lymph nodes was 41 (range, 39-50 lymph nodes). Conclusions SpRHC is safe and feasible. However, further comparative studies are needed to assess whether this procedure can provide patients with significant benefits compared with multiport robotic surgery. | Song, S. H.; Kim, H. J.; Choi, G. -S.; Park, J. S.; Park, S. Y.; Lee, S. -M.; Choi, J. A. | Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Colorectal Canc Ctr, 807 Hogukro, Daegu 41404, South Korea | 57221771693; 57204567554; 8058759100; 35226761100; 12242293700; 55236751200; 8692733000 | kyuschoi@mail.knu.ac.kr; | TECHNIQUES IN COLOPROCTOLOGY | TECH COLOPROCTOL | 1123-6337 | 1128-045X | 25 | 9 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;SURGERY | 2021 | 3.699 | 23.2 | 1.97 | 2025-07-30 | 19 | 19 | Single-port robotic surgery; Single-port robotic right hemicolectomy; Right colon cancer; Robotic surgery | LAPAROSCOPIC RIGHT HEMICOLECTOMY; RIGHT COLECTOMY; INCISION LAPAROSCOPY; SYSTEM; FEASIBILITY; SURGERY; SAFETY | Right colon cancer; Robotic surgery; Single-port robotic right hemicolectomy; Single-port robotic surgery | Aged; Colectomy; Colonic Neoplasms; Humans; Laparoscopy; Lymph Node Excision; Male; Operative Time; Robotic Surgical Procedures; Robotics; adult; advanced cancer; aged; anastomosis; Article; cancer chemotherapy; clinical article; clinical feature; colon cancer; colon surgery; feasibility study; female; hemicolectomy; human; incision; length of stay; lymph node dissection; lymph node size; male; operation duration; outcome assessment; perioperative period; process development; robot assisted surgery; safety; treatment duration; wound infection; colon resection; colon tumor; laparoscopy; robotics | English | 2021 | 2021-09 | 10.1007/s10151-021-02482-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Long-term clinical outcomes of total mesorectal excision and selective lateral pelvic lymph node dissection for advanced low rectal cancer: a comparative study of a robotic versus laparoscopic approach | Background The long-term outcomes of minimally invasive lateral pelvic lymph node dissection (LPND) are not completely known. The aim of this study was to compare long-term outcomes between robotic and laparoscopic LPND in low rectal cancer patients with suspected lymph node metastasis in the pelvic sidewall. Methods We retrospectively reviewed the records of all rectal cancer patients who had laparoscopic or robotic total mesorectal excision (TME) with LPND between March 2006 and June 2016. Stage IV patients were excluded. The outcomes of patients who had laparoscopic and robotic TME with LPND were compared. Results Twenty-nine patients had laparoscopic LPND and 70 had robotic LPND. No significant differences in patient characteristics were observed between the two groups. The urinary retention rate was lower in the robotic group than in the laparoscopic group (7.1% vs. 24.1%; p = 0.043). During a median follow-up of 44.3 months, the overall recurrence rates were 48.3% and 31.4% in the laparoscopic and robotic groups, respectively (p = 0.175). The 5-year disease-free survival rates were 50.4% and 67.0% in the laparoscopic and robotic groups, respectively (p = 0.227). The 5-year overall survival rates were 65.0% and 92.2% in the laparoscopic and robotic groups, respectively (p = 0.017). Conclusions Robotic TME with LPND is safe and feasible. In particular, it is associated with lower urinary retention. Robotic TME with LPND might yield a similar local recurrence rate and 5-year disease-free survival, but favorable long-term overall survival as compared to the laparoscopic approach. However, considering the retrospective nature and both major variables of TME and LPND involved together, this should be cautiously interpreted. | Song, S. H.; Choi, G. -S.; Kim, H. J.; Park, J. S.; Park, S. Y.; Lee, S. -M.; Choi, J. A.; Seok, H. A. | Kyungpook Natl Univ, Chilgok Hosp, Colorectal Canc Ctr, Sch Med, 807 Hogukro, Daegu 40414, South Korea | 57221771693; 8058759100; 57204567554; 35226761100; 12242293700; 56824903400; 8692733000; 57222000502 | kyuschoi@knu.ac.kr; | TECHNIQUES IN COLOPROCTOLOGY | TECH COLOPROCTOL | 1123-6337 | 1128-045X | 25 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;SURGERY | 2021 | 3.699 | 23.2 | 2.5 | 2025-07-30 | 26 | 25 | Lymph nodes; Lymph node excision; Laparoscopy; Disease-free survival; Robotic surgical procedures; Rectal neoplasms; Neoplasm recurrence; Overall survival | Disease-free survival; Laparoscopy; Lymph node excision; Lymph nodes; Neoplasm recurrence; Overall survival; Rectal neoplasms; Robotic surgical procedures | Humans; Laparoscopy; Lymph Node Excision; Lymph Nodes; Neoplasm Recurrence, Local; Rectal Neoplasms; Retrospective Studies; Robotic Surgical Procedures; Treatment Outcome; alpha adrenergic receptor blocking agent; abdominal infection; adult; age; aged; American Society of Anaesthesiologists score; anastomosis leakage; Article; body mass; cancer recurrence; cancer staging; chemoradiotherapy; clinical outcome; comparative study; disease association; disease free survival; drug use; feasibility study; female; follow up; gender; heart disease; human; ileus; laparoscopic surgery; lateral pelvic lymph node dissection; limb weakness; lymph node metastasis; major clinical study; male; minimally invasive surgery; overall survival; patient safety; pelvis lymphadenectomy; postoperative care; postoperative complication; postoperative hemorrhage; preoperative care; rectovaginal fistula; rectum cancer; retrospective study; robot assisted surgery; surgical approach; surgical infection; surgical mortality; total mesorectal excision; tumor localization; urine retention; very elderly; laparoscopy; lymph node; lymph node dissection; rectum tumor; treatment outcome; tumor recurrence | English | 2021 | 2021-04 | 10.1007/s10151-020-02383-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Transcriptional response in the whiteleg shrimp (Penaeus vannamei) to short-term microplastic exposure | The ingestion of microplastics by diverse marine organisms induces behavioral disorders, physiological changes, and immune and stress responses. The negative effects of microplastic exposure in penaeid shrimps are still unclear despite the annual increase in the consumption of these food sources by humans and in marine aquaculture. Therefore, this study aimed to investigate the potential negative effects of microplastic exposure and gain a deeper understanding of its impacts on culturing penaeid shrimp. We generated RNA sequencing data from the whiteleg shrimp (Penaeus vannamei) artificially exposed to microplastics and analyzed the differentially expressed genes. Based on transcriptional comparisons, exposure to microplastics induces cardiac muscle dysfunction and promotes stress and immune responses in whiteleg shrimp. Thus, we confirmed the negative impact of microplastic exposure in whiteleg shrimp. These results provide a foundation for studies on the biological effects of microplastic ingestion on aquaculture species and their potential impact on humans through their consumption of these important marine resources. | Han, Jee Eun; Choi, Seong-Kyoon; Jeon, Hye Jin; Park, Jin-Kyu; Han, Se-Hyeon; Jeong, Jinyoung; Kim, Ji Hyung; Lee, JunMo | Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; DGIST, Core Prot Resources Ctr, Daegu 42988, South Korea; DGIST, Div Biotechnol, Daegu 42988, South Korea; Seoul Broadcasting Syst, Dept News Team, Seoul 07574, South Korea; Korea Res Inst Biosci & Biotechnol, Environm Dis Res Ctr, Daejeon 34141, South Korea; Korea Res Inst Biosci & Biotechnol, Infect Dis Res Ctr, Daejeon, South Korea; Kyungpook Natl Univ, Dept Oceanog, Daegu 41566, South Korea | Jeong, Jinyoung/MBH-8618-2025; Kim, Ji Hyung/B-7321-2011 | 57214671240; 55505432500; 57212193058; 35213723500; 57210915063; 56665544700; 57225000204; 57217851052 | kzh81@kribb.re.kr;junmolee@knu.ac.kr; | AQUACULTURE REPORTS | AQUACULT REP | 2352-5134 | 20 | SCIE | FISHERIES | 2021 | 3.385 | 23.2 | 1.97 | 2025-07-30 | 20 | 20 | Penaeid shrimp; Microplastic exposure; Negative impact; Cardiac muscle dysfunction; Stress response; Immune response | STRESS-RESPONSE; BETA-ARRESTINS; THYMIDINE PHOSPHORYLASE; APOLIPOPROTEIN-D; GENES TRPV5; EXPRESSION; INGESTION; EXCHANGER; HEART; NCX1 | Cardiac muscle dysfunction; Immune response; Microplastic exposure; Negative impact; Penaeid shrimp; Stress response | English | 2021 | 2021-07 | 10.1016/j.aqrep.2021.100713 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Deep learning based prediction of necessity for orthognathic surgery of skeletal malocclusion using cephalogram in Korean individuals | Background Posteroanterior and lateral cephalogram have been widely used for evaluating the necessity of orthognathic surgery. The purpose of this study was to develop a deep learning network to automatically predict the need for orthodontic surgery using cephalogram. Methods The cephalograms of 840 patients (Class ll: 244, Class lll: 447, Facial asymmetry: 149) complaining about dentofacial dysmorphosis and/or a malocclusion were included. Patients who did not require orthognathic surgery were classified as Group I (622 patients-Class ll: 221, Class lll: 312, Facial asymmetry: 89). Group II (218 patients-Class ll: 23, Class lll: 135, Facial asymmetry: 60) was set for cases requiring surgery. A dataset was extracted using random sampling and was composed of training, validation, and test sets. The ratio of the sets was 4:1:5. PyTorch was used as the framework for the experiment. Results Subsequently, 394 out of a total of 413 test data were properly classified. The accuracy, sensitivity, and specificity were 0.954, 0.844, and 0.993, respectively. Conclusion It was found that a convolutional neural network can determine the need for orthognathic surgery with relative accuracy when using cephalogram. | Shin, WooSang; Yeom, Han-Gyeol; Lee, Ga Hyung; Yun, Jong Pil; Jeong, Seung Hyun; Lee, Jong Hyun; Kim, Hwi Kang; Kim, Bong Chul | Korea Inst Ind Technol KITECH, Safety Syst Res Grp, Gyongsan, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Coll IT Engn, Daegu, South Korea; Wonkwang Univ, Daejeon Dent Hosp, Dept Oral & Maxillofacial Radiol, Coll Dent, Daejeon, South Korea; Wonkwang Univ, Daejeon Dent Hosp, Dept Oral & Maxillofacial Surg, Coll Dent, Daejeon, South Korea | Kim, Bong/ABB-3866-2020; Lee, jaeho/ABE-6242-2020 | 57221727628; 57208645237; 57222474273; 16644164300; 57219224526; 57221622970; 57222486045; 55578739400 | bck@wku.ac.kr; | BMC ORAL HEALTH | BMC ORAL HEALTH | 1472-6831 | 21 | 1 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2021 | 3.747 | 23.4 | 6.94 | 2025-07-30 | 60 | 61 | Cephalogram; Machine learning; Machine intelligence; Orthognathic surgery | ARTIFICIAL-INTELLIGENCE; NEURAL-NETWORKS | Cephalogram; Machine intelligence; Machine learning; Orthognathic surgery | Cephalometry; Deep Learning; Humans; Malocclusion; Malocclusion, Angle Class III; Orthognathic Surgery; Orthognathic Surgical Procedures; Republic of Korea; cephalometry; diagnostic imaging; human; malocclusion; orthognathic surgery; South Korea | English | 2021 | 2021-03-18 | 10.1186/s12903-021-01513-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Impact of temporary closures of emergency departments during the COVID-19 outbreak on clinical outcomes for emergency patients in a metropolitan area | Background: During the early phase of the coronavirus disease 2019 (COVID-19) outbreak, many emergency departments (EDs) were exposed to COVID-19 and were temporarily closed according to national protocol of Korea. We aimed to evaluate the effect of concurrent and recurrent temporary closures of EDs on the clinical outcomes of patients who visited EDs during the COVID-19 outbreak. Methods: This cross-sectional study used a nationwide emergency patient database. Patients who visited one of the 46 EDs in Daegu and Gyeongbuk between January 21 and April 14, 2020 were included. The main exposure variable was the first medical contact (ED visit or 119 call to emergency medical services (EMS)) during closure of at least one ED. There were 25 temporary closures of six Level-1 and Level-2 EDs between February 18 and March 17, 2020. We constructed a dataset by performing bidirectional crossover matching and conducted a conditional logistic regression analysis where the primary outcome was in-hospital mortality. Results: Of the 94,360 eligible study participants, 36,327 were classified into the non-EMS-use group and 10,116 were classified into the EMS-use group. In-hospital mortality rates were 2.0% and 1.6% for the temporary-closure and no-closure groups in the non-EMS-use group (p-value, 0.03) and 8.7% and 7.4% in the EMS-use group (p-value, 0.02), respectively. In the conditional logistic analysis for in-hospital mortality, the odds ratios (95% confidence intervals) of the temporary-closure group compared the no-closure group were 1.22 (1.03-1.44) among the non-EMS-use group and 1.23 (1.04-1.46) among the EMS-use group. Conclusion: The temporary closures of EDs due to the unpredicted COVID-19 exposure resulted in an increase in emergency patients' in-hospital mortality rates irrespective of whether they used EMS. Preparing regional EMS systems to cope with new outbreaks is essential to protect the safety of all citizens. (c) 2021 Elsevier Inc. All rights reserved. | Lee, Dong Eun; Ro, Young Sun; Ryoo, Hyun Wook; Moon, Sungwoo | Kyungpook Natl Univ, Chilgok Hosp, Dept Emergency Med, Sch Med, Daegu, South Korea; Natl Med Ctr, Natl Emergency Med Ctr, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Emergency Med, 101 Daehak Ro, Seoul 03080, South Korea; Seoul Natl Univ Hosp, Lab Emergency Med Serv, Biomed Res Inst, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Emergency Med, Sch Med, Daegu, South Korea; Korea Univ, Dept Emergency Med, Ansan Hosp, Gyeonggi, South Korea | Lee, Dong Eun/HTN-4501-2023 | 57202299238; 37665990400; 55350557500; 8725859700 | delee18589@gmail.com;Ro.youngsun@gmail.com;ryoo@knu.ac.kr;sungwoo.moon89@gmail.com; | AMERICAN JOURNAL OF EMERGENCY MEDICINE | AM J EMERG MED | 0735-6757 | 1532-8171 | 47 | SCIE | EMERGENCY MEDICINE | 2021 | 4.093 | 23.4 | 2.45 | 2025-07-30 | 15 | 15 | COVID-19; Emergency medical services; Mortality | ASSOCIATION; EXPOSURE | COVID-19; Emergency medical services; Mortality | Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; COVID-19; Cross-Sectional Studies; Databases, Factual; Disease Outbreaks; Emergency Service, Hospital; Female; Health Facility Closure; Hospital Mortality; Humans; Infant; Infant, Newborn; Logistic Models; Male; Middle Aged; Republic of Korea; SARS-CoV-2; Young Adult; adult; aged; Article; child; controlled study; coronavirus disease 2019; cross-sectional study; crossover procedure; emergency health service; emergency patient; emergency ward; epidemic; female; health care access; hospital mortality; human; Korea; major clinical study; male; middle aged; mortality rate; newborn; outcome assessment; patient care; patient participation; patient safety; population structure; prediction; priority journal; retrospective study; school child; urban hospital; very elderly; adolescent; diagnosis; epidemic; epidemiology; factual database; health care facility; hospital emergency service; infant; preschool child; South Korea; statistical model; therapy; young adult | English | 2021 | 2021-09 | 10.1016/j.ajem.2021.03.038 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Influenza-associated Neurologic Complications in Hospitalized Pediatric Patients A Multicenter Retrospective Study in Republic of Korea | Background: The rates of influenza-associated neurologic complications are variable among studies, and a difference has been observed between the Western and Asian countries. The study aims to evaluate the frequency and characteristics of influenza-associated neurologic complications. Methods: We performed a retrospective review of hospitalized cases of influenza infection from October 2010 to April 2017 from 3 referral hospitals. Results: A total of 1988 influenza cases were identified. Influenza-associated neurologic complications were 161 cases (8.1%); influenza virus A was detected in 113 (70.2%) cases, B in 47 (29.2%) cases and both A and B in 1 case (0.6%). Twenty-four patients (15%) had underlying neurologic diseases. The most common diagnosis was a simple febrile convulsion (44%), followed by complex febrile convulsion (29%), fever-provoked seizure under pre-existing neurologic disease or afebrile seizure (14%), encephalopathy/encephalitis (8%) and meningitis (5%). Most of the patients fully recovered (96%). Three patients (1.9%) died of myocarditis (n = 1), encephalopathy (n = 1), and simultaneous encephalitis and myocarditis (n = 1). Pre-existing neurologic disease, age groups of 6 months to 6 years and 6-12 years were a risk factor of influenza-associated neurologic complications with an adjusted odds ratio of 5.41 (95% confidence interval [CI] 3.23-9.06, P < 0.001), 12.99 (95% CI 1.77-95.19, P = 0.01) and 8.54 (95% CI 1.14-64.79, P = 0.04), respectively. There was no association between neuropsychiatric adverse events and oseltamivir prescription (P = 0.17). Conclusions: Influenza-associated neurologic complications are not uncommon, and most patients fully recovered. The frequency of influenza-associated neurologic complications in Korean children was not significantly different from that of children in Western countries. | Choi, Gwang-Jun; Park, Ji Young; Choi, Joon-Sik; Choi, Sae Rom; Kim, Dongsub; Lee, Jun Hwa; Woo, Young-Jong; Lee, Jeehun; Kim, Yae-Jean | Sungkyunkwan Univ, Sch Med, Dept Pediat, Samsung Med Ctr, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Dept Pediat, Samsung Changwon Hosp, Seoul, South Korea; Samsung Biomed Res Inst, Ctr Clin Res, Seoul, South Korea; Chonnam Natl Univ, Sch Med, Dept Pediat, Chonnam Natl Univ Hosp, Gwangju, South Korea; Div Infect Dis Control, Daegu Metropolitan City, South Korea; Chung Ang Univ, Chung Ang Univ Hosp, Dept Pediat, Coll Med, Seoul, South Korea; Yonsei Univ, Yongin Severance Hosp, Dept Pediat, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Pediat, Sch Med, Daegu, South Korea | Lee, Jun Hwa/GWZ-3737-2022; Park, Ji Young/KDO-4256-2024; Kim, Junetae/AAS-1234-2021 | yaejeankim@skku.edu; | PEDIATRIC INFECTIOUS DISEASE JOURNAL | PEDIATR INFECT DIS J | 0891-3668 | 1532-0987 | 40 | 12 | SCIE | IMMUNOLOGY;INFECTIOUS DISEASES;PEDIATRICS | 2021 | 3.806 | 23.5 | 12 | encephalopathy; encephalitis; seizures; meningitis; oseltamivir | SEASONAL INFLUENZA; ABNORMAL-BEHAVIOR; CHILDREN; INFECTION; MANIFESTATIONS; ENCEPHALOPATHY; OSELTAMIVIR; ADULTS; VIRUS | English | 2021 | 2021-12 | 10.1097/inf.0000000000003332 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Morphology and phylogenetic relationships of two new Antarctic species in phylogroup Chloromonadinia (Volvocales, Chlorophyceae) | The phylogroup Chloromonadinia (Volvocales, Chlorophyceae) comprises green microalgae that inhabit a variety of environments, including freshwater, soil, and snow. Two strains were isolated from two sites in the South Shetland Islands in maritime Antarctica, and their morphological and molecular characteristics were studied. Light microscopy of the strain KSF0090 revealed ellipsoidal or broad ellipsoidal, sometimes almost spherical cells with a chloroplast without a pyrenoid, a prominent eyespot, and a hemispherical papilla. The vegetative cells of KSF0208 were ellipsoidal to ovoid cells with a chloroplast with a central pyrenoid, a linear eyespot, and a papilla. The two strains differed from other closely related species based on size and the aforementioned morphological characteristics. Nuclear small subunit rDNA sequence data indicated that each strain formed a distinct well-supported lineage within the phylogroup Chloromonadinia. In addition, comparative analyses of the secondary structures of internal transcribed spacer 2 and compensatory base changes were used to identify and characterize the two strains. Based on their morphological and molecular characteristics, we propose KSF0090 and KSF0208 as two new species, Chloromonas deceptionensis sp. nov. and Ostravamonas greenwichensis sp. nov., respectively. | Chae, Hyunsik; Kim, Eun Jae; Lim, Sooyeon; Kim, Han Soon; Choi, Han-Gu; Kim, Sanghee; Kim, Ji Hee | Korea Polar Res Inst, Div Life Sci, Incheon 21990, South Korea; Kyungpook Natl Univ, Sch Life Sci, Daegu 41566, South Korea; Geninus, Genome Analysing Team, Seoul 05836, South Korea | Kim, Hee-Jin/P-1903-2015 | 55785278500; 57217796922; 57212867561; 7410135359; 34876408000; 57208574704; 56271013400 | jhalgae@kopri.re.kr; | PHYCOLOGIA | PHYCOLOGIA | 0031-8884 | 2330-2968 | 60 | 3 | SCIE | MARINE & FRESHWATER BIOLOGY;PLANT SCIENCES | 2021 | 3.088 | 23.5 | 0.1 | 2025-07-30 | 2 | 2 | Chloromonas deceptionensis; Internal transcribed spacer 2; Molecular phylogeny; Ostravamonas greenwichensis | TAXONOMIC REASSESSMENT | Chloromonas deceptionensis; Internal transcribed spacer 2; Molecular phylogeny; Ostravamonas greenwichensis | English | 2021 | 2021-05-04 | 10.1080/00318884.2021.1893005 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | PRIMARY ENDOSYMBIOSIS OF PHOTOSYNTHETIC PAULINELLA REVEALED BY GENOMICS | Lhee, Duckhyun; Lee, JunMo; Ettahi, Khaoula; Cho, Chung Hyun; Ha, Ji-San; Chan, Ya-Fan; Zelzion, Udi; Stephens, Timothy G.; Price, Dana C.; Gabr, Arwa; Nowack, Eva C. M.; Bhattacharya, Debashish; Yoon, Hwan Su | Sungkyunkwan Univ, Dept Biol Sci, Suwon 16419, South Korea; Kyungpook Natl Univ, Dept Oceanog, Daegu 41566, South Korea; Rutgers State Univ, Dept Biochem & Microbiol, New Brunswick, NJ 08901 USA; Rutgers State Univ, Dept Entomol, Ctr Vector Biol, New Brunswick, NJ 08901 USA; Rutgers State Univ, Microbiol & Mol Genet Grad Program, New Brunswick, NJ 08854 USA; Heinrich Heine Univ, Inst Mikrobielle Zellbiol, D-40225 Dusseldorf, Germany | Cho, Chung Hyun/AAM-1233-2020; Nowack, Eva/F-7879-2018 | PHYCOLOGIA | PHYCOLOGIA | 0031-8884 | 2330-2968 | 60 | SCIE | MARINE & FRESHWATER BIOLOGY;PLANT SCIENCES | 2021 | 3.088 | 23.5 | 0 | Chromatophore; photosynthetic amoeba; primary endosymbiosis | English | 2021 | 2021-07-01 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | Sequential afatinib and osimertinib in patients with EGFR mutation-positive NSCLC and acquired T790M: A global non-interventional study (UpSwinG) | Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are standard of care for EGFR mutation-positive non-small cell lung cancer (NSCLC). However, optimal sequence of treatment has yet to be defined. Overall survival (OS) is influenced by the availability/use of subsequent therapy after first-line treatment. Emergence of T790M is the main mechanism of resistance to afatinib and second-line osimertinib could be a treatment option in this instance. Methods: In this non-interventional, global study (NCT04179890), existing medical/electronic records were identified for consecutive EGFR TKI-naive patients with EGFR mutation-positive NSCLC (Del19 or L858R) treated with first-line afatinib and second-line osimertinib in regular clinical practice (n = 191; all T790M-positive). The primary objective was time to treatment failure (TTF). Key secondary objectives were OS and objective response rate (ORR). Results: At the start of afatinib treatment, median age (range) was 62 years (34-88). Fifty-five percent of patients were female and 67% were Asian. ECOG PS (0/1/>= 2) was 31%/57%/12%. Fourteen percent of patients had brain metastases. At the start of osimertinib treatment, ECOG PS (0/1/>= 2) was 25%/61%/14% and 14% had brain metastases (rising to 29% at the end of osimertinib treatment). The source of biopsy material (solid/liquid) was 86%/3% at the start of afatinib and 54%/33% at start of osimertinib. Mutations were mainly detected with PCR methods. Overall, median TTF was 27.7 months (95% CI: 24.0-30.2) and median OS was 36.5 months (95% CI: 32.9-41.8). ORR with afatinib and osimertinib was 74% and 45%. TTF, OS and ORR were generally consistent across subgroups. Conclusion: Sequential afatinib and osimertinib demonstrated encouraging activity in patients with EGFR mutation-positive NSCLC and acquired T790M. Activity was observed across all subgroups, including patients with poor ECOG PS or brain metastases. ECOG PS and incidence of brain metastases remained stable prior to, and after, afatinib treatment. | Popat, Sanjay; Jung, Hyun Ae; Lee, Shin Yup; Hochmair, Maximilian J.; Lee, Seung Hyeun; Escriu, Carles; Lee, Min Ki; Migliorino, Maria R.; Lee, Yong Chul; Girard, Nicolas; Daoud, Hasan; Marten, Angela; Miura, Satoru | Royal Marsden Natl Hlth Serv Fdn Trust, Lung Unit, 203 Fulham Rd, London SW3 6JJ, England; Inst Canc Res, London, England; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Hematol Oncol,Dept Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Karl Landsteiner Inst Lung Res & Pulm Oncol, Klin Floridsdorf, Dept Resp & Crit Care Med, Vienna, Austria; Kyung Hee Univ, Sch Med, Div Pulm & Crit Care Med, Dept Internal Med,Med Ctr, Seoul, South Korea; Clatterbridge Canc Ctr, Wirral, Merseyside, England; Pusan Natl Univ, Sch Med, Dept Internal Med, Busan, South Korea; San Camillo Forlanini Hosp, Rome, Italy; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Res Ctr Pulm Dis, Dept Internal Med,Biomed Res Inst,Med Sch, Jeonju, South Korea; Inst Thorax Curie Montsouris, Inst Curie, Paris, France; UVSQ, Paris Saclay, St Aubin, France; Boehringer Ingelheim Int GmbH, Ingelheim, Germany; Niigata Canc Ctr Hosp, Dept Internal Med, Niigata, Japan | Popat, Sanjay/AAO-1634-2021; Girard, Nicolas/IAO-8135-2023; Lee, Seung Hyeun/P-5566-2018 | 6701774598; 35272249400; 49863712700; 14032862400; 57208400366; 55255182600; 16433227400; 6603705901; 57191489788; 56443626100; 57292162300; 7003348582; 22934797200 | Sanjay.Popat@rmh.nhs.uk;hyunae.jung@samsung.com;shinyup@knu.ac.kr;hausruck@gmail.com;humanmd04@hanmail.net;Carles.escriu@nhs.net;leemk@pusan.ac.kr;mmigliorino@scamilloforlanini.rm.it;leeyc@chonbuk.ac.kr;nicolas.girard2@curie.fr;hasan.daoud@boehringer-ingelheim.com;angela.maerten@boehringer-ingelheim.com;miusat1118@niigata-cc.jp; | LUNG CANCER | LUNG CANCER | 0169-5002 | 1872-8332 | 162 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2021 | 6.081 | 23.5 | 1.57 | 2025-07-30 | 24 | 23 | EGFR; Afatinib; Osimertinib; Sequential; T790M | CELL LUNG-CANCER; 1ST-LINE TREATMENT; OPEN-LABEL; GEFITINIB | Afatinib; EGFR; Osimertinib; Sequential; T790M | Acrylamides; Afatinib; Aniline Compounds; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Female; Humans; Lung Neoplasms; Middle Aged; Mutation; Protein Kinase Inhibitors; afatinib; epidermal growth factor receptor; osimertinib; acrylamide derivative; afatinib; aniline derivative; EGFR protein, human; epidermal growth factor receptor; osimertinib; protein kinase inhibitor; adult; aged; Article; brain metastasis; drug withdrawal; ECOG Performance Status; epidermal growth factor receptor gene; female; gene mutation; high throughput sequencing; human; liquid biopsy; major clinical study; male; non small cell lung cancer; objective response rate; overall survival; polymerase chain reaction; retrospective study; time to treatment failure; treatment duration; treatment failure; treatment response; genetics; lung tumor; middle aged; mutation; non small cell lung cancer | English | 2021 | 2021-12 | 10.1016/j.lungcan.2021.09.009 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | UNUSUAL MITOCHONDRIAL GENOME EXPANSION IN THREE PORPHYRIDIUM SPECIES (RHODOPHYTA) | Kim, Dongseok; Lee, JunMo; Graf, Louis; Cho, Chung Hyun; Kim, Eun Jeung; Bhattacharya, Debashish; Yoon, Hwan Su | Sungkyunkwan Univ, Dept Biol Sci, Suwon 16419, South Korea; Kyungpook Natl Univ, Dept Oceanog, Daegu 41566, South Korea; Rutgers State Univ, Dept Biochem & Microbiol, New Brunswick, NJ 08901 USA | Cho, Chung Hyun/AAM-1233-2020 | dongseokkim6662@gmail.com; | PHYCOLOGIA | PHYCOLOGIA | 0031-8884 | 2330-2968 | 60 | SCIE | MARINE & FRESHWATER BIOLOGY;PLANT SCIENCES | 2021 | 3.088 | 23.5 | 0 | Red algae; group II intron; replication slippage | English | 2021 | 2021-07-01 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | ○ | Article | Controlling the geometric design of anodic 1D TiO2 nanotubes for the electrochemical reduction of 2,4,6-trinitrotoluene in ambient conditions | In this study, we investigated how the geometric design of anodic one-dimensional (1D) TiO2 nanotube arrays affected their performance in the electrochemical reduction of 2,4,6-trinitrotoluene (2,4,6-TNT) in aqueous solutions and ambient conditions. Two main geometric parameters were considered: the inner diameter and length of TiO2 nanotubes. The various TiO2 nanotubes were fabricated using an anodization technique performed in four types of fluoride-containing organic solvents by adjusting various anodization parameters. All as-prepared samples successfully detected 2,4,6-TNT in an aqueous solution using cyclic voltammetry and linear sweep voltammetry. Three peaks corresponding to the reduction of each nitro group in 2,4,6-TNT were observed between - 0.5 and - 1.0 V (versus Ag/AgCl, 3 M KCl). Further, we discovered that nanotube length affected 2,4,6-TNT reduction performance. We also performed experiments at various concentrations of 2,4,6-TNT and determined the sensitivity to be 1.78 x 10-3 mA cm-2 ppm-1, the limit of detection to be 6.49 ppm, and the limit of quantitation to be 21.6 ppm 2,4,6-TNT over a linear range of 20 - 100 ppm using an electrode with nanotube inner diameter of 75 nm and length of 6 mu m. A simple and fast fabricated composite-free 1D TiO2 nanotube arrays electrode can form the basis for future studies in enhancing the detection sensitivity. Electrochemical detection of other nitro-based compounds, such as nitroglycerin, nitrocellulose, picric acid, and their mixtures, require further investigation. | Moon, Sanghyeon; Charyulu, Devarayapalli Kamakshaiah; Lee, Wonjoo; Lee, Kiyoung | Inha Univ, Dept Chem & Chem Engn, 100 Inha Ro, Incheon 22212, South Korea; Kyungpook Natl Univ, Res Inst Environm Sci & Technol, 80 Daehak Ro, Daegu 41566, South Korea; Daeduk Univ, Div Mil Sci, 68 Gajeongbuk Ro, Daejeon 34111, South Korea | Lee, Kiyoung/J-8680-2013 | 57217595243; 57270640000; 57215807492; 57219211501 | wjlee@ddu.ac.kr;kiyoung@inha.ac.kr; | JOURNAL OF ELECTROANALYTICAL CHEMISTRY | J ELECTROANAL CHEM | 1572-6657 | 1873-2569 | 900 | SCIE | CHEMISTRY, ANALYTICAL;ELECTROCHEMISTRY | 2021 | 4.598 | 23.6 | 0.58 | 2025-07-30 | 9 | 9 | Anodization; TiO2 nanotubes; 2; 4; 6-trinitrotoluene; Geometric design; Electrochemical reduction | MASS-SPECTROMETRY; CARBON; EXPLOSIVES; SENSOR; NANOPARTICLES; PERFORMANCE; GRAPHENE; NITROGEN; BIOTRANSFORMATION; NITROAROMATICS | 2,4,6-trinitrotoluene; Anodization; Electrochemical reduction; Geometric design; TiO<sub>2</sub> nanotubes | Chemical detection; Cyclic voltammetry; Electrochemical electrodes; Fluorine compounds; Geometry; Nanotubes; Potassium compounds; Titanium dioxide; % reductions; 2,4,6-trinitrotoluene; Ambient conditions; Anodizations; Electrochemical reductions; Geometric design; Inner diameters; Nanotube arrays; Performance; TiO 2 nanotube; Electrolytic reduction | English | 2021 | 2021-11-01 | 10.1016/j.jelechem.2021.115717 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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