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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Genetic Study in Korean Pediatric Patients with Steroid-Resistant Nephrotic Syndrome or Focal Segmental Glomerulosclerosis | Steroid-resistant nephrotic syndrome (SRNS) is one of the major causes of end-stage renal disease (ESRD) in childhood and is mostly associated with focal segmental glomerulosclerosis (FSGS). More than 50 monogenic causes of SRNS or FSGS have been identified. Recently, the mutation detection rate in pediatric patients with SRNS has been reported to be approximately 30%. In this study, genotype-phenotype correlations in a cohort of 291 Korean pediatric patients with SRNS/FSGS were analyzed. The overall mutation detection rate was 43.6% (127 of 291 patients).WT1was the most common causative gene (23.6%), followed byCOQ6(9.4%),NPHS1(8.7%),NUP107(7.1%), andCOQ8B(6.3%). Mutations inCOQ6,NUP107, andCOQ8Bwere more frequently detected, and mutations inNPHS2were less commonly detected in this cohort than in study cohorts from Western countries. The mutation detection rate was higher in patients with congenital onset, those who presented with proteinuria or chronic kidney disease/ESRD, and those who did not receive steroid treatment. Genetic diagnosis in patients with SRNS provides not only definitive diagnosis but also valuable information for decisions on treatment policy and prediction of prognosis. Therefore, further genotype-phenotype correlation studies are required. | Park, Eujin; Lee, Chung; Kim, Nayoung K. D.; Ahn, Yo Han; Park, Young Seo; Lee, Joo Hoon; Kim, Seong Heon; Cho, Min Hyun; Cho, Heeyeon; Yoo, Kee Hwan; Shin, Jae Il; Kang, Hee Gyung; Ha, Il-Soo; Park, Woong-Yang; Cheong, Hae Il | Seoul Natl Univ, Dept Pediat, Coll Med, Seoul 03080, South Korea; Hallym Univ, Kangnam Sacred Heart Hosp, Dept Pediat, Coll Med, Seoul 07441, South Korea; Samsung Med Ctr, Samsung Genome Inst, Seoul 06351, South Korea; GENINUS Inc, Seoul 05836, South Korea; Univ Ulsan, Asan Med Ctr, Dept Pediat, Childrens Hosp,Coll Med, Seoul 05505, South Korea; Pusan Natl Univ, Dept Pediat, Childrens Hosp, Yangsan 50612, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu 41944, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, Seoul 06351, South Korea; Korea Univ, Dept Pediat, Guro Hosp, Seoul 02841, South Korea; Yonsei Univ, Dept Pediat, Coll Med, Seoul 03722, South Korea; Severance Childrens Hosp, Div Pediat Nephrol, Seoul 03722, South Korea; Sungkyunkwan Univ, Dept Mol Cell Biol, Sch Med, Suwon 16419, South Korea | SHIN, JAE IL/J-6922-2017; Kim, Seong/AAD-8853-2020; Kim, Jeong/AAO-6927-2021; Park, Eujin/AAZ-5931-2020; Lee, Chung/KRP-3824-2024 | 56194662500; 58482922800; 56532228100; 57219957477; 56701214400; 37112404100; 57213778393; 7401727726; 15724272900; 7202592702; 57964880100; 7404071546; 7005904938; 7402229389; 34567974000 | eujinpark@hallym.or.kr;spinelyc@gmail.com;bionkdk@gmail.com;medicalpooh@hanmail.net;yspark@amc.seoul.kr;pedkid@gmail.com;pedksh@gmail.com;chomh@knu.ac.kr;heeyeon1.cho@samsung.com;guroped@korea.ac.kr;shinji@yuhs.ac;kanghg@snu.ac.kr;ilsooha@snu.ac.kr;woongyang.park@samsung.com;cheonghi@snu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 6 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 1.59 | 2025-06-25 | 36 | 38 | steroid-resistant nephrotic syndrome; focal segmental glomerulosclerosis; genetic analysis | MESANGIAL SCLEROSIS; GLOMERULAR PROTEIN; NPHS2 MUTATIONS; DEFICIENCY; KIDNEY; ONSET; ASSOCIATION; CHILDREN; VARIANTS; DISEASE | Focal segmental glomerulosclerosis; Genetic analysis; Steroid-resistant nephrotic syndrome | corticosteroid; creatinine; nilotinib; steroid; ubidecarenone; Alport syndrome; Article; child; chromosome aberration; chronic kidney failure; clinical article; cohort analysis; congenital nephrotic syndrome; copy number variation; correlational study; disorders of mitochondrial functions; end stage renal disease; estimated glomerular filtration rate; Fabry disease; female; focal glomerulosclerosis; gene frequency; gene mutation; genetic analysis; genetic variation; glomerulosclerosis; glomerulus filtration rate; gonadoblastoma; heteroplasmy; human; kidney function; kidney transplantation; lactic acidosis; major clinical study; male; MELAS syndrome; personalized medicine; polymerase chain reaction; prenatal diagnosis; preschool child; proteinuria; restriction fragment length polymorphism; Sanger sequencing; single nucleotide polymorphism; whole exome sequencing | English | 2020 | 2020-06 | 10.3390/jcm9062013 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Improving the Prognostic Performance of SUVmaxin¹⁸F-Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography Using Tumor-to-Liver and Tumor-to-Blood Standard Uptake Ratio for Locally Advanced Cervical Cancer Treated with Concurrent Chemoradiotherapy | Objective: We sought to evaluate whether the(18)F-fluorodeoxyglucose uptake normalization of the primary tumor to both the liver and blood pool and lymph nodes to both the liver and blood pool can enhance the discrimination for prognosis prediction in patients with cervical cancer. Methods: A total of 156 patients with cervical cancer (International Federation of Gynecology and Obstetrics stages IIB-IV) treated with concurrent chemoradiotherapy (CCRT) were enrolled. The maximum standardized uptake value (SUVmax) of tumor (tSUV(max)) and the lymph node (nSUV(max)) divided by the SUV(mean)of the liver (tumor-to-liver ratio (TLR) and node-to-liver (NLR)) and blood pool (tumor-to-blood ratio (TBR) and node-to-blood ratio (NBR)) were investigated. Univariate and multivariate analyses of disease-free survival (DFS) and overall survival (OS) were performed using clinical and metabolic parameters. A receiver operating characteristic curve analysis was performed to compare the accuracy of the metabolic parameters. Results: The multivariate analysis revealed that NLR (hazard ratio ((HR): 3.54; 95% confidence interval (CI): 1.53-8.19;p= 0.0032) and NBR (HR: 3.38; 95% CI: 1.02-11.19;p= 0.0457)) were independent prognostic factors for DFS, while TLR (HR: 4.16; 95% CI: 1.19-14.50;p= 0.0252), TBR (HR: 3.01; 95% CI: 1.04-8.70;p= 0.0415), NLR (HR: 4.84; 95% CI: 1.58-14.81;p= 0.0057), and NBR (HR: 6.87; 95% CI: 1.55-30.54;p= 0.0113) were significant prognostic factors for OS. The normalization of tSUV(max)to the liver or blood pool enhanced the discrimination for prediction of recurrence (tSUV(max)vs. TLR;p= 0.0056 and tSUV(max)vs. TBR;p= 0.0099) and death (tSUV(max)vs. TLR;p< 0.0001 and tSUV(max)vs. TBR;p= 0.0001). Conclusions: The normalization of tSUV(max)was an independent prognostic factor and improved the discrimination for the prediction of tumor recurrence and death in patients with locally advanced cervical cancer treated with CCRT. | Chong, Gun Oh; Jeong, Shin Young; Lee, Yoon Hee; Park, Shin-Hyung; Lee, Hyun Jung; Lee, Sang-Woo; Hong, Dae Gy; Lee, Yoon Soon | Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41944, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Obstet & Gynecol, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Nucl Med, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Radiat Oncol, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Obstet & Gynecol, Daegu 41944, South Korea | Park, Shinhyung/LNQ-6428-2024; lee, sangwoo/KUD-1906-2024 | 23099068000; 36164032500; 37088851700; 57203275843; 57202930844; 57196249819; 26656670100; 27172173100 | gochong@knu.ac.kr;syjeong@knu.ac.kr;yhlee1017@knu.ac.kr;shinhyungpark@knu.ac.kr;obgy1019@hanmail.net;swleenm@knu.ac.kr;chssa0220@hanmail.net;yslee@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 6 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0.08 | 2025-06-25 | 4 | 4 | locally advanced cervical cancer; F-18-FDG PET; CT; SUVmax; tumor-to-liver ratio; tumor-to-blood ratio; prognosis | LYMPH-NODES; VOLUME; CHEMOTHERAPY; CARCINOMA; THERAPY; PET/CT; MRI | <sup>18</sup>F‐FDG PET/CT; Locally advanced cervical cancer; Prognosis; SUV<sub>max</sub>; Tumor to‐blood ratio; Tumor‐to‐liver ratio | fluorodeoxyglucose f 18; adult; advanced cancer; Article; cancer prognosis; cancer staging; cancer survival; chemoradiotherapy; disease free survival; female; follow up; human; lymph node metastasis; major clinical study; maximum standardized uptake value; middle aged; muscle exercise; oncological parameters; overall survival; positron emission tomography-computed tomography; retrospective study; tumor-to-blood ratio; tumor-to-liver ratio; uterine cervix cancer | English | 2020 | 2020-06 | 10.3390/jcm9061878 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Interhemispheric Functional Connectivity in the Primary Motor Cortex Assessed by Resting-State Functional Magnetic Resonance Imaging Aids Long-Term Recovery Prediction among Subacute Stroke Patients with Severe Hand Weakness | This study aimed to evaluate the usefulness of interhemispheric functional connectivity (FC) as a predictor of motor recovery in severe hand impairment and to determine the cutoff FC level as a clinically useful parameter. Patients with stroke (n = 22; age, 59.9 +/- 13.7 years) who presented with unilateral severe upper-limb paresis and were confirmed to elicit no motor-evoked potential responses were selected. FC was measured using resting-state functional magnetic resonance imaging (rsfMRI) scans at 1 month from stroke onset. The good recovery group showed a higher FC value than the poor recovery group (p = 0.034). In contrast, there was no statistical difference in FC value between the good recovery and healthy control groups (p = 0.182). Additionally, the healthy control group showed a higher FC value than that shown by the poor recovery group (p = 0.0002). Good and poor recovery were determined based on Brunnstrom stage of upper-limb function at 6 months as the standard, and receiver operating characteristic curve indicated that a cutoff score of 0.013 had the greatest prognostic ability. In conclusion, interhemispheric FC measurement using rsfMRI scans may provide useful clinical information for predicting hand motor recovery during stroke rehabilitation. | Min, Yu-Sun; Park, Jang Woo; Park, Eunhee; Kim, Ae-Ryoung; Cha, Hyunsil; Gwak, Dae-Won; Jung, Seung-Hwan; Chang, Yongmin; Jung, Tae-Du | Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Rehabil Med, Daegu 41944, South Korea; Seoul Natl Univ, Dept Biomed Engn, Coll Med, Seoul 03080, South Korea; Kyungpook Natl Univ, Dept Med & Biol Engn, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea | 48061349800; 57202928230; 56107216400; 57196257330; 57189728122; 57212010177; 57223283117; 7501840633; 36622364500 | ssuni119@naver.com;giantstar.jw@gmail.com;ehmdpark@naver.com;ryoung20@hanmail.net;hscha1002@daum.net;eodnjs108@naver.com;pyromyth@naver.com;ychang@knu.ac.kr;teeed0522@hanmail.net; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 4 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 1.03 | 2025-06-25 | 18 | 20 | functional magnetic resonance imaging; neuronal plasticity; recovery of function; stroke; motor cortex | UPPER-LIMB RECOVERY; PATHWAYS; ONSET | Functional magnetic resonance imaging; Motor cortex; Neuronal plasticity; Recovery of function; Stroke | adult; aged; Article; brain ischemia; cerebrovascular accident; clinical article; controlled study; convalescence; echo planar imaging; female; functional connectivity; functional magnetic resonance imaging; hand function; human; lesion volume; male; middle aged; motor evoked potential; nerve cell plasticity; neuroimaging; primary motor cortex; receiver operating characteristic; stroke patient; stroke rehabilitation; very elderly | English | 2020 | 2020-04 | 10.3390/jcm9040975 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Lipophilic Environmental Chemical Mixtures Released During Weight-Loss: The Need to Consider Dynamics | Intentional weight loss can increase health risk in the long-term, despite short-term benefits, because human adipose tissue is widely contaminated with various lipophilic environmental contaminants, especially persistent organic pollutants (POPs). Recently, chronic exposure to low POPs has emerged as a new risk factor for common metabolic diseases and cardiovascular diseases. The amount of POPs released from adipocytes to the circulation increases during weight loss, thereby increasing POPs exposure of other critical organs. Possible harmful effects due to release of POPs during weight loss are opposite to those usually expected from losing weight. It is speculated that this tradeoff can explain recent puzzling findings on intensive weight loss. The presence of POPs in adipose tissue adds a challenge to weight management and an optimal strategy of weight management needs to consider both fat mass and dynamics of POPs. | Lee, Duk-Hee; Jacobs, David R., Jr.; Lind, Lars; Lind, P. Monica | Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu 41944, South Korea; Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA; Uppsala Univ, Dept Med Sci, Cardiovasc Epidmiol, Uppsala 75237, Sweden; Uppsala Univ, Dept Med Sci, Occupat & Environm Med, Uppsala 75185, Sweden | Lind, Lars/KAM-1968-2024; Lind, Monica/B-6677-2017; Jacobs, David/G-5405-2011 | 57211851121; 57200715827; 26643471200; 7102202987 | lee_dh@knu.ac.kr; | BIOESSAYS | BIOESSAYS | 0265-9247 | 1521-1878 | 42 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY | 2020 | 4.345 | 23.1 | 0.45 | 2025-06-25 | 10 | 13 | cardiovascular diseases; diabetes; obesity; persistent organic pollutants; weight loss | PERSISTENT ORGANIC POLLUTANTS; LIFE-STYLE; ADIPOSE-TISSUE; SERUM CONCENTRATIONS; METABOLIC DISEASES; OBESE INDIVIDUALS; ASSOCIATIONS; MORTALITY; EXPOSURE; OUTCOMES | cardiovascular diseases; diabetes; obesity; persistent organic pollutants; weight loss | Adipose Tissue; Environmental Pollutants; Humans; Obesity; Risk Factors; Weight Loss; environmental chemical; adipose tissue; Article; body mass; body weight loss; body weight management; cardiovascular risk; human; lipophilicity; obesity; persistent organic pollutant; physical activity; pollutant; risk factor | English | 2020 | 2020-06 | 10.1002/bies.201900237 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Management and Prognosis of Heart Failure in Octogenarians: Final Report from the KorAHF Registry | Treatment of heart failure (HF) in the elderly face many difficulties due to lack of robust evidence. We analyzed the outcome of HF in octogenarians using a nationwide HF registry. Among 5625 patients from the Korean Acute Heart Failure (KorAHF) registry, prognosis of octogenarian HF and the association of guideline-directed medical therapy (GDMT) with mortality and readmissions were analyzed. Octogenarian patients (1185, 22.4%) showed a higher mortality, and males were especially at increased risk (HR (hazard ratio) 1.19, 95% CI 1.01-1.40). A J-curve association between blood pressure (BP) and mortality was observed regardless of age, but the nadir value was lower in octogenarians (123.8 vs. 127.9 mmHg for systolic blood pressure (SBP); 67.1 vs. 73.9 mmHg for diastolic blood pressure (DBP), p < 0.001). Use of GDMT in octogenarian patients with HF and reduced ejection fraction (EF) were inadequate (74.3%, 47.1%, and 46.1% in octogenarians vs. 78.4%, 59.8%, and 55.2% in non-elderly for renin-angiotensin system inhibitors, beta-blockers, and aldosterone antagonists, respectively; all p < 0.05). However, those on medications had a significant reduction in 6 month mortality. For octogenarians with HF and preserved EF, angiotensin receptor blocker use reduced hospitalizations for HF in men (HR 0.19, 95% CI 0.04-0.87), but not in women (p-interaction = 0.037). HF in octogenarians were found to have different characteristics compared with the non-elderly. However, adequate use of GDMT was still associated with improved survival, and more attention should be given to prescribing medications with clinical benefits. | Oh, Gyu Chul; Cho, Hyun-Jai; Lee, Sang Eun; Kim, Min-Seok; Kim, Jae-Joong; Choi, Jin-Oh; Jeon, Eun-Seok; Hwang, Kyung-Kuk; Chae, Shung Chull; Baek, Sang Hong; Kang, Seok-Min; Yoo, Byung-Su; Choi, Dong-Ju; Ahn, Youngkeun; Kim, Kye Hun; Cho, Myeong-Chan; Oh, Byung-Hee; Lee, Hae-Young | Seoul Natl Univ Hosp, Dept Internal Med, Seoul 03080, South Korea; Asan Med Ctr, Dept Cardiol, Seoul 05505, South Korea; Sungkyunkwan Univ, Coll Med, Dept Med, Seoul 16419, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju 28644, South Korea; Kyungpook Natl Univ, Coll Med, Dept Internal Med, Daegu 37224, South Korea; Catholic Univ Korea, Dept Internal Med, Seoul 06591, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul 03722, South Korea; Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju 26426, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam 13620, South Korea; Chonnam Natl Univ, Heart Res Ctr, Gwangju 61469, South Korea | Choi, Joon/D-6140-2017; Oh, Byung-Hee/G-9875-2011; Choi, Dong-Ju/J-5686-2012; Kim, Soo-Yeon/ADR-9663-2022; Jeong, Gi/AAB-2830-2021; Oh, Gyu/AAJ-6530-2021; LEE, JI/L-6920-2013 | 52264473100; 35285421400; 57207065107; 57212315719; 36065764100; 15848011800; 7004279641; 7402426370; 7101962036; 7201371594; 7405685375; 7102851884; 35274349200; 56937721300; 56150430800; 7401727518; 57216293873; 56151235500 | david.gyuchul@gmail.com;hyunjaicho@snu.ac.kr;sangeunlee.md@gmail.com;guess124@gmail.com;jjkim@amc.seoul.kr;choijean5@gmail.com;eunseok.jeon@samsung.com;kyungkukhwang@gmail.com;scchae@knu.ac.kr;whitesh@catholic.ac.kr;smkang@yumc.yonsei.ac.kr;yubs@yonsei.ac.kr;djchoi@snubh.org;cecilyk@chonnam.ac.kr;cvkimkh@gmail.com;mccho@chungbuk.ac.kr;ohbhmed@snu.ac.kr;hylee612@snu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0.4 | 2025-06-25 | 5 | 7 | heart failure; guideline-directed medical therapy; sex difference; octogenarians; J-curve; mortality | REDUCED EJECTION FRACTION; RANDOMIZED-TRIAL; ELDERLY-PATIENTS; MEDICAL THERAPY; BLOOD-PRESSURE; MORTALITY; SPIRONOLACTONE; MORBIDITY | Guideline-directed medical therapy; Heart failure; J-curve; Mortality; Octogenarians; Sex difference | aldosterone antagonist; amino terminal pro brain natriuretic peptide; angiotensin receptor antagonist; beta adrenergic receptor blocking agent; dipeptidyl carboxypeptidase; dipeptidyl carboxypeptidase inhibitor; hemoglobin; natriuretic factor; aged; all cause mortality; Article; body mass; clinical outcome; clinical trial; comparative study; device therapy; diastolic blood pressure; disease registry; estimated glomerular filtration rate; female; follow up; heart ejection fraction; heart failure; hospital discharge; hospital readmission; hospitalization; human; major clinical study; male; mortality; multicenter study; outcome assessment; prognosis; renin angiotensin aldosterone system; survival rate; systolic blood pressure; very elderly | English | 2020 | 2020-02 | 10.3390/jcm9020501 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Marginal and Internal Fit of Ceramic Restorations Fabricated Using Digital Scanning and Conventional Impressions: A Clinical Study | This clinical study was designed with the aim of fabricating four ceramic crowns using the conventional method and digital methods with three different intraoral scanners and evaluate the marginal and internal fit as well as clinician satisfaction. We enrolled 20 subjects who required ceramic crowns in the upper or lower molar or the premolar. Impressions were obtained using digital scans, with conventional impressions (polyvinyl siloxane and desktop scanner) and three different intraoral scanners (EZIS PO, i500, and CS3600). Four lithium disilicate glass-ceramic crowns were fabricated for each patient. In the oral cavity, the proximal and occlusal adjustments were performed, and the marginal fit and internal fit were evaluated using the silicone replica technique. The clinician satisfaction score of the four crowns was evaluated as per the evaluations of the proximal and occlusal contacts made during the adjustment process and the marginal and internal fit. For statistical analysis, the differences among the groups were analyzed with one-way analysis of variance and Tukey HSD test as a post-test; Pearson correlation analysis was used for analyzing the correlations (alpha = 0.05). There was a significant difference in the marginal and internal fit of the ceramic crowns fabricated using three intraoral scanner types and one desktop scanner type (p < 0.001); there was a significant difference in the clinician satisfaction scores (p = 0.04). The clinician satisfaction score and marginal fit were significantly correlated (absolute marginal discrepancy and marginal gap) (p < 0.05). An impression technique should be considered for fabricating a ceramic crown with excellent goodness-of-fit. Further, higher clinician satisfaction could be obtained by reproducing the excellent goodness-of-fit using the intraoral scanning method as compared to the conventional method. | Lee, Jeong-Hyeon; Son, Keunbada; Lee, Kyu-Bok | Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Adv Dent Device Dev Inst A3DI, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Dent Sci, 2177 Dalgubeol Daero, Daegu 41940, South Korea | SON, Keunbada/AAG-8089-2019; Son, Keunbada/AAG-8089-2019 | 57219115610; 57202916520; 15925571200 | prossn@naver.com;sonkeunbada@gmail.com;kblee@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 12 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0.96 | 2025-06-25 | 17 | 20 | marginal and internal fit; intraoral scanner; conventional method; ceramic crown; digital workflow | PRESS-ON-METAL; PROSTHESES; ACCURACY; SYSTEMS | Ceramic crown; Conventional method; Digital workflow; Intraoral scanner; Marginal and internal fit | glass; lithium; silicone; siloxane; accuracy; adult; analysis of variance; Article; ceramics; clinical article; clinician; computer aided design/computer aided manufacturing; controlled study; correlation analysis; dentist; female; human; male; molar tooth; mouth cavity; occlusal adjustment; pilot study; premolar tooth; product parameters; satisfaction; scoring system; workflow | English | 2020 | 2020-12 | 10.3390/jcm9124035 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Neutrophil-Lymphocyte Ratio in Patients with Acute Heart Failure Predicts In-Hospital and Long-Term Mortality | The application of a simple blood test to predict prognosis in acute heart failure (AHF) patients is not well established. Neutrophil-lymphocyte ratio (NLR) is inexpensive and easy to obtain in hospitalized patients using a routine blood test. We evaluate the prognostic implications of NLR as an independent predictor of in-hospital and long-term mortality in AHF patients. Among 5625 patients enrolled in the Korean Acute Heart Failure registry, 5580 patients were classified into quartiles by their NLR level, and analyzed for in-hospital and post-discharge three-year mortality. Patients in the highest NLR quartile had the highest in-hospital and post-discharge three-year mortality. The same results were seen by dividing the aggravating factor into the infection or ischemia group and the non-infection or non-ischemia group. For patients aggravated from infection or ischemia, a cut-off NLR value was 7.0 that increase the risk of in-hospital and post-discharge three-year mortality. In subgroups of patients not aggravated from infection or ischemia, a cut-off NLR value was 5.0 that increase the risk of in-hospital and post discharge three-year mortality. Elevated NLR in AHF patients at the index hospitalization is an independent predictor for in-hospital and post-discharge three-year mortality. Taken together, NLR is a marker for risk assessment of AHF patients. | Cho, Jun Hwan; Cho, Hyun-Jai; Lee, Hae-Young; Ki, You-Jeong; Jeon, Eun-Seok; Hwang, Kyung-Kuk; Chae, Shung Chull; Baek, Sang Hong; Kang, Seok-Min; Choi, Dong-Ju; Yoo, Byung-Su; Kim, Kye Hun; Kim, Jae-Joong; Oh, Byung-Hee | Chung Ang Univ Hosp, Coll Med, Cardiovasc Arrhythmia Ctr, Heart Res Inst, Seoul 06973, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul 03080, South Korea; Sungkyunkwan Univ, Coll Med, Dept Internal Med, Seoul 06351, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju 28644, South Korea; Kyungpook Natl Univ, Coll Med, Dept Internal Med, Daegu 41944, South Korea; Catholic Univ Korea, Dept Internal Med, Seoul 06591, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul 03722, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam 13620, South Korea; Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju 26426, South Korea; Chonnam Natl Univ, Heart Res Ctr, Gwangju 61469, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Cardiol, Seoul 05505, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 03080, South Korea; Mediplex Sejong Hosp, Dept Cardiol, Incheon 21080, South Korea | ; Jeong, Gi/AAB-2830-2021; Oh, Byung-Hee/G-9875-2011; Lee, Hye-Young/JEP-8044-2023; choi, jo/O-5940-2014; Choi, Dong-Ju/J-5686-2012 | 57198513492; 35285421400; 56151235500; 57202030642; 7004279641; 7402426370; 7101962036; 7201371594; 7405685375; 35274349200; 7102851884; 56150430800; 36065764100; 57216293873 | cardio.jhcho@gmail.com;hyunjaicho@snu.ac.kr;hylee612@snu.ac.kr;drkiyou@gmail.com;eunseok.jeon@samsung.com;kyungkukhwang@gmail.com;scchae@knu.ac.kr;whitesh@catholic.ac.kr;smkang@yumc.yonsei.ac.kr;djchoi@snu.ac.kr;yubs@yonsei.ac.kr;KIJ10@lycos.co.kr;jjkim@amc.seoul.kr;ohbhmed@snu.ac.kr;hyunjaicho@gmail.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 3.5 | 2025-06-25 | 64 | 72 | acute heart failure; survival; mortality; outcome; neutrophil-lymphocyte ratio | MYOCARDIAL-INFARCTION; PROGNOSTIC VALUE; DEATH; COUNT; DISEASES; DESIGN | Acute heart failure; Mortality; Neutrophil-lymphocyte ratio; Outcome; Survival | albumin; angiotensin 2 receptor antagonist; brain natriuretic peptide; creatinine; hemoglobin; sodium; acute heart failure; adult; aged; all cause mortality; Article; blood pressure; blood sampling; body mass; clinical outcome; controlled study; creatinine blood level; estimated glomerular filtration rate; female; follow up; heart left ventricle ejection fraction; hemoglobin blood level; hospital admission; hospital mortality; hospitalization; human; leukocyte count; long term care; major clinical study; male; neutrophil lymphocyte ratio; overall survival; prediction; prognosis; prospective study; risk assessment; sodium blood level; transthoracic echocardiography; urea nitrogen blood level | English | 2020 | 2020-02 | 10.3390/jcm9020557 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Optimizing Preparative Regimen for Umbilical Cord Blood Transplantation in Adult Acute Leukemia Patients: Acute Lymphoblastic Leukemia Requires Myeloablative Conditioning but Not Acute Myeloid Leukemia | Cord blood transplantation (CBT) is a valuable alternative to bone marrow transplantation in adults without readily available donors. We conducted this study to investigate the feasibility of CBT for adult patients with acute leukemia with regards to impact of different conditioning and graft-versus-host disease (GVHD) prophylaxis regimens on clinical outcomes. From 16 centers in Korea, 41 acute myeloid leukemia (AML) and 29 ALL (acute lymphoblastic leukemia) patients undergoing CBT were enrolled. For AML patients, the neutrophil engraftment was observed in 87.5% of reduced intensity conditioning (RIC) and 72.0% of myeloablative conditioning (MAC) (p= 0.242). The median RFS was 5 months and OS 7 months. Conditioning regimen did not affect relapse free survival (RFS) or overall survival (OS). GVHD prophylaxis using calcineurin inhibitors (CNI) plus methotrexate was associated with better RFS compared to CNI plus ATG (p= 0.032). For ALL patients, neutrophil engraftment was observed in 55.6% of RIC and 90.0% of MAC (p= 0.034). The median RFS was 5 months and OS 19 months. MAC regimens, especially total body irradiation (TBI)-based regimen, were associated with both longer RFS and OS compared to other conditioning regimens. In conclusion, individualized conditioning regimens will add value in terms of enhancing safety and efficacy of CBT. | Byun, Ja Min; Hong, Junshik; Oh, Doyeun; Yhim, Ho-Young; Do, Young Rok; Park, Joon Seong; Jung, Chul Won; Yang, Deok-Hwan; Won, Jong-Ho; Lee, Hong Ghi; Moon, Joon Ho; Mun, Yeung-Chul; Jo, Deog-Yeon; Han, Jae Joon; Lee, Je-Hwan; Lee, Jae Hoon; Lee, Junglim; Yoon, Sung-Soo | Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Seoul 03080, South Korea; CHA Univ, Dept Internal Med, Sch Med, Seongnam 13496, South Korea; Jeonbuk Natl Univ, Dept Internal Med, Med Sch, Jeonju 54907, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Internal Med, Sch Med, Daegu 42601, South Korea; Ajou Univ, Dept Hematol Oncol, Sch Med, Suwon 16499, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Internal Med, Sch Med, Seoul 06351, South Korea; Chonnam Natl Univ, Div Hematol Oncol, Hwasun Hosp, Hwasun 58128, South Korea; Soonchunhyang Univ, Dept Internal Med, Div Hematol & Med Oncol, Seoul Hosp, Seoul 04401, South Korea; Konkuk Univ, Dept Internal Med, Div Hematol Oncol, Med Ctr, Seoul 05030, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol & Oncol, Daegu 41944, South Korea; Ewha Womans Univ, Dept Internal Med, Sch Med, Seoul 07985, South Korea; Chungnam Natl Univ, Dept Internal Med, Coll Med, Daejeon 35015, South Korea; Kyung Hee Univ, Coll Med, Dept Hematol & Med Oncol, Seoul 02447, South Korea; Univ Ulsan, Asan Med Ctr, Dept Hematol, Coll Med, Seoul 05505, South Korea; Gachon Univ, Dept Internal Med, Div Hematol, Coll Med,Gil Med Ctr, Incheon 21565, South Korea; Daegu Fatima Hosp, Dept Internal Med, Div Hematol & Med Oncol, 99 Ayang Ro, Daegu 41199, South Korea | ; , 한재준(의과대학 의학과)/AAT-6350-2020; Lee, Dae Young/ADO-9686-2022; Yoon, Sung-Soo/J-2773-2012; Lee, Jeong/JFA-4725-2023; Park, Jung Hyun/HJA-3755-2022; Won, Jongho/AAM-8322-2021; Lee, Jae-Hyun/ABE-3803-2020; Byun, Ja/AAI-2125-2020 | 57191727590; 18634264100; 7203001784; 35785270600; 8960168300; 57685470700; 56405934800; 8701758000; 26434081600; 35327071800; 56568642700; 7003363716; 57205440382; 57203488910; 16637544900; 56013463700; 16203096000; 7404036304 | jaminbyun@naver.com;alertjun@hanmail.net;doh@cha.ac.kr;yhimhy@naver.com;dyr1160@dsmc.or.kr;jspark65@ajou.ac.kr;chulwonl.jung@samsung.com;drydh1685@hotmail.com;jhwon.sch@gmail.com;mlee@kuh.ac.kr;jhmoon74@naver.com;yeungchul@ewha.ac.kr;deogyeon@cnu.ac.kr;jchriste@naver.com;jhlee3@amc.seoul.kr;jhlee@gilhospital.com;junglim3@gmail.com;ssysmc@snu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 7 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0 | 2025-06-25 | 0 | 0 | cord blood transplantation; acute myeloid leukemia; acute lymphoblastic leukemia; conditioning | ALTERNATIVE DONOR TRANSPLANTATION; STEM-CELL TRANSPLANTATION; VERSUS-HOST-DISEASE; UNRELATED DONOR; BONE-MARROW; COMPLETE REMISSION; OLDER PATIENTS; RECIPIENTS; CHILDREN; SINGLE | Acute lymphoblastic leukemia; Acute myeloid leukemia; Conditioning; Cord blood transplantation | busulfan; cyclophosphamide; cyclosporine; cytarabine; etoposide; fludarabine; HLA DRB1 antigen; melphalan; methotrexate; mycophenolate mofetil; tacrolimus; thiotepa; thymocyte antibody; acute leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; adult; aged; allogeneic stem cell transplantation; Article; bone marrow transplantation; cardiopulmonary bypass; controlled study; cord blood stem cell transplantation; Cytomegalovirus; female; follow up; graft versus host reaction; hematopoietic stem cell transplantation; HLA typing; human; liver venoocclusive disease; major clinical study; male; mortality; myeloablative conditioning; neutrophil count; overall survival; platelet count; recurrence free survival; umbilical cord blood; whole body radiation | English | 2020 | 2020-07 | 10.3390/jcm9072310 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Outcomes of COVID-19 among Patients on In-Center Hemodialysis: An Experience from the Epicenter in South Korea | Patients with advanced chronic kidney disease (CKD) or who are on hemodialysis (HD) could have increased susceptibility to the 2019 coronavirus disease (COVID-19) given their pre-existing comorbidities, older age, compromised immune system, and regular visits to populated outpatient dialysis centers. This study included 14 consecutive patients on HD or with advanced CKD who initiated HD after being diagnosed with laboratory-confirmed COVID-19 from February to April 2020 in hospitals throughout Daegu, South Korea. The included patients, 42.9% of whom were men, had a mean age of 63.5 years. Four patients had a history of contact with a patient suffering from COVID-19. The most common symptom was cough (50.0%), followed by dyspnea (35.7%). The mean time from symptom onset to diagnosis and admission was 2.6 and 3.5 days, respectively. Patients exhibited lymphopenia and elevated inflammatory markers, including C-reactive protein and ferritin. Chest radiography findings showed pulmonary infiltration in 10 patients. All patients underwent regular HD in a negative pressure room and received antiviral agents. Four patients received mechanical ventilation and continuous renal replacement therapy at a median duration of 14.0 and 8.5 days, respectively. One patient underwent extracorporeal membrane oxygenation for three days. Among the 14 patients included, two died due to acute respiratory distress syndrome, nine were discharged from the hospital, and three remained hospitalized. Despite the high-risk conditions associated with worse outcomes, patients on HD did not exhibit extremely poor overall COVID-19 outcomes perhaps due to early diagnosis, prompt hospitalization, and antiviral therapy. | Jung, Hee-Yeon; Lim, Jeong-Hoon; Kang, Seok Hui; Kim, Seong Gyu; Lee, Yong-Hoon; Lee, Jaehee; Chang, Hyun-Ha; Kim, Shin-Woo; Choi, Ji-Young; Cho, Jang-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Park, Sun-Hee | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Div Nephrol,Dept Internal Med, Daegu 41944, South Korea; Yeungnam Univ, Dept Internal Med, Div Nephrol, Med Ctr, Daegu 42415, South Korea; Daegu Catholic Univ, Dept Internal Med, Div Nephrol, Med Ctr, Daegu 42472, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Div Pulm & Crit Care Med,Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Div Infect Dis,Dept Internal Med, Daegu 41944, South Korea | Cho, Jang-hee/ABD-3534-2020; Kim, Yong-Lim/AGK-3172-2022; Lim, Jeong-Hoon/ABE-6003-2020; Lee, Jaehee/S-1697-2018; Lee, Jun Young/CAI-2335-2022; Jung, Hee-Yeon/AFB-8578-2022; Park, Sun-Hee/LMN-0033-2024 | 57196396467; 55360244300; 35269232600; 57208897521; 57199022948; 13805476000; 7407521688; 8710731500; 7501393222; 7403536291; 8558530700; 55633533600; 7501831741 | hy-jung@knu.ac.kr;jh-lim@knu.ac.kr;kangkang@ynu.ac.kr;shaorangun@gmail.com;id0121@naver.com;jaelee@knu.ac.kr;changhha@knu.ac.kr;ksw2kms@knu.ac.kr;jyss1002@hanmail.net;jh-cho@knu.ac.kr;drcdkim@knu.ac.kr;ylkim@knu.ac.kr;sh-park@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 6 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 1.99 | 2025-06-25 | 27 | 26 | COVID-19; SARS-CoV-2; hemodialysis; South Korea | CORONAVIRUS DISEASE 2019; CLINICAL CHARACTERISTICS; PROCALCITONIN; EPIDEMIC; WUHAN | COVID-19; Hemodialysis; SARS-CoV-2; South Korea | alkaline phosphatase; C reactive protein; ferritin; glucocorticoid; hydroxychloroquine; lactate dehydrogenase; lopinavir plus ritonavir; adult; adult respiratory distress syndrome; aged; antiviral therapy; Article; artificial ventilation; cardiovascular disease; Charlson Comorbidity Index; computer assisted tomography; coronavirus disease 2019; coughing; diabetes mellitus; dyspnea; extracorporeal oxygenation; female; fever; hemodialysis; hospitalization; human; hypertension; length of stay; lymphocytopenia; major clinical study; male; middle aged; mortality rate; oxygen therapy; quarantine; renal replacement therapy; retrospective study; reverse transcription polymerase chain reaction; Severe acute respiratory syndrome coronavirus 2; South Korea; tachycardia; tachypnea; thorax radiography; very elderly | English | 2020 | 2020-06 | 10.3390/jcm9061688 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Potential Salivary mRNA Biomarkers for Early Detection of Oral Cancer | We evaluated potential biomarkers in human whole saliva for the early diagnosis of oral squamous cell carcinoma (OSCC). We selected 30 candidate genes with relevance to cancer from recent reports in PubMed. Saliva samples were obtained from 34 non-tumor control and 33 OSCC patients. Real-time PCR was performed, and mRNA levels were compared. Normalized mRNA levels of six genes (NGFI-A binding protein 2 (NAB2), cytochrome P450, family 27, subfamily A, polypeptide 1 (CYP27A1), nuclear pore complex interacting protein family, member B4 (NPIPB4), monoamine oxidase B (MAOB), sialic acid acetyltransferase (SIAE), and collagen, type III, alpha 1 (COL3A1)) were significantly lower in saliva of OSCC patients. Receiver operating characteristics (ROC) analysis was used to individually evaluate the predictive power of the potential biomarkers for OSCC diagnosis. The area under the curve (AUC) values were evaluated for the OSCC vs. non-tumor groups via univariate ROC analyses, as well as multivariate ROC analyses of combinations of multiple potential biomarkers. The combination of CYP27A1 + SIAE showed a favorable AUC value of 0.84. When we divided saliva samples into two groups according to age using a 60-year cut-off, with OSCC patients and controls evaluated together, the AUC of MAOB-NAB2 was more predictive of OSCC in the under-60 group (AUC, 0.91; sensitivity, 0.92; and specificity, 0.86) than any other gene combination. These results are expected to aid the early diagnosis of OSCC, especially in patients under 60 years of age. While more studies with larger numbers of patients are necessary, our result suggest that salivary mRNA would be a potent biomarker for early OSCC diagnosis. | Oh, Su Young; Kang, Sung-Min; Kang, Soo Hyun; Lee, Heon-Jin; Kwon, Tae-Geon; Kim, Jin-Wook; Lee, Sung-Tak; Choi, So-Young; Hong, Su-Hyung | Kyungpook Natl Univ, Sch Dent, Dept Microbiol & Immunol, Daegu 700412, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Daegu 700412, South Korea | 57204016703; 59499667300; 57204021325; 36462383000; 35205433300; 55862646000; 55931708300; 57202918688; 8691449100 | oohsuy@knu.ac.kr;dkdkdk43@knu.ac.kr;black_bean@knu.ac.kr;heonlee@knu.ac.kr;kwondk@knu.ac.kr;vocaleo@knu.ac.kr;st0907@knu.ac.kr;dentalchoi@knu.ac.kr;hongsu@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 2.15 | 2025-06-25 | 32 | 38 | oral squamous cell carcinoma; saliva; early diagnosis; mRNA; area under the curve | SQUAMOUS-CELL CARCINOMA; MONOAMINE-OXIDASE; CURVE ANALYSIS; TRANSCRIPTOME; PERIODONTITIS; MICROARRAY; EXPRESSION; DIAGNOSIS; PCR | Area under the curve; Early diagnosis; MRNA; Oral squamous cell carcinoma; Saliva | amine oxidase (flavin containing) isoenzyme B; biological marker; cholestanetriol 26 monooxygenase; collagen type 3; messenger RNA; nucleoporin; adult; aged; Article; clinical article; collagen type 3 alpha 1 gene; controlled study; cytochrome P450 27A1 gene; diagnostic test accuracy study; DNA microarray; early diagnosis; female; gene; gene expression; human; male; middle aged; monoamine oxidase B gene; mouth squamous cell carcinoma; NGFI A binding protein 2 gene; nuclear pore complex interacting protein B4 gene; prediction; real time polymerase chain reaction; receiver operating characteristic; saliva analysis; sensitivity and specificity; sialic acid acetyltransferase gene; very elderly | English | 2020 | 2020-01 | 10.3390/jcm9010243 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Prediction of Motor Recovery in Patients with Basal Ganglia Hemorrhage Using Diffusion Tensor Imaging | Predicting prognosis in patients with basal ganglia hemorrhage is difficult. This study aimed to investigate the usefulness of diffusion tensor imaging in predicting motor outcome after basal ganglia hemorrhage. A total of 12 patients with putaminal hemorrhage were included in the study (aged 50 +/- 12 years), 8 patients were male (aged 46 +/- 11 years) and 4 were female (aged 59 +/- 9 years). We performed diffusion tensor imaging and measured clinical outcome at baseline (pre) and 3 weeks (post1), 3 months (post2), and 6 months (post3) after the initial treatment. In the affected side of the brain, the mean fractional anisotropy (FA) value on pons was significantly higher in the good outcome group than that in the poor outcome group at pre (p = 0.004) and post3 (p = 0.025). Pearson correlation analysis showed that mean FA value at pre significantly correlated with the sum of the Brunnstrom motor recovery stage scores at post3 (R = 0.8, p = 0.002). Change in the FA ratio on diffusion tractography can predict motor recovery after hemorrhagic stroke. | Min, Yu-Sun; Jang, Kyung Eun; Park, Eunhee; Kim, Ae-Ryoung; Kang, Min-Gu; Cheong, Youn-Soo; Kim, Ju-Hyun; Jung, Seung-Hwan; Park, Jaechan; Jung, Tae-Du | Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Rehabil Med, Daegu 41944, South Korea; Seoul Natl Univ, Coll Med, Dept Biomed Engn, Seoul 03080, South Korea; Kyungpook Natl Univ, Dept Med & Biomed Engn, Daegu 41944, South Korea; Dong A Univ, Coll Med, Dept Phys Med & Rehabil, Busan 49201, South Korea; Maryknoll Hosp, Dept Rehabil Med, Busan 48972, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu 41944, South Korea; Kyungpook Natl Univ, Biomed Res Inst, Sch Med, Daegu 41944, South Korea | 48061349800; 56740018300; 56107216400; 57196257330; 57205351774; 57040715600; 57208450909; 57223283117; 44661451000; 36622364500 | ssuni119@gmail.com;soulmate907@naver.com;ehmdpark@naver.com;ryoung20@hanmail.net;kangmingu.ryan@gmail.com;dbstnone@naver.com;kjoohyun88@gmail.com;pyromyth@naver.com;jparkneurosurgery@gmail.com;teeed0522@hanmail.net; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 5 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0.32 | 2025-06-25 | 7 | 7 | diffusion tensor imaging; magnetic resonance imaging; recovery; rehabilitation; stroke | INTRACEREBRAL HEMORRHAGE; WALLERIAN DEGENERATION; PROPORTIONAL RECOVERY; STROKE; TRACT; MECHANISMS; HEMATOMA; INJURY; LIMB | Diffusion tensor imaging; Magnetic resonance imaging; Recovery; Rehabilitation; Stroke | adult; Article; Barthel index; basal ganglion hemorrhage; brain hemorrhage; brain injury assessment; brunnstrom motor recovery stage; clinical article; clinical outcome; diffusion tensor imaging; female; flaccid paralysis; follow up; fractional anisotropy; Glasgow coma scale; human; jebsen hand function test; magnetic resonance angiography; male; middle aged; modified ranson scale; motor dysfunction assessment; motricity index; National Institutes of Health Stroke Scale; nuclear magnetic resonance imaging; prediction; putaminal hemorrhage; pyramidal tract; range of motion; tractography | English | 2020 | 2020-05 | 10.3390/jcm9051304 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Prognosis-Predicting Model Based on [¹⁸F]fluorodeoxyglucose PET Metabolic Parameters in Locally Advanced Cervical Cancer Patients Treated with Concurrent Chemoradiotherapy: Multi-Center Retrospective Study | This study aimed to develop a prognosis-predicting model based on [F-18]fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) and clinicopathologic factors in locally advanced cervical cancer patients treated with concurrent chemoradiotherapy (CCRT). The medical records of 270 locally advanced cervical cancer patients who were treated with CCRT were collected from three institutions and reviewed retrospectively. A nomogram was used for predicting 2-year disease-free survival (DFS) and 5-year overall survival (OS) based on Cox proportional hazards regression. Predictor variables included nodal maximum standardized uptake value (SUVmax), primary tumor SUVmax, age, tumor size, stage, serum squamous cell carcinoma antigen level, and human papillomavirus status. Internal nomogram validation was performed. A nomogram for predicting the 2-year DFS and 5-year OS was constructed using six and seven parameters, respectively. With a focus on 2-year DFS, our model found nodal SUVmax to be the highest weighted negative prognostic factor. With a focus on 5-year OS, young age was the highest weighted negative prognostic factor. The concordance index was 0.75 and 0.78 for the 2-year DFS and 5-year OS, respectively. This nomogram is a predictive tool that can be used to counsel patients for predicting survival outcomes. Moreover, our prognosis-predicting model may make it possible to personalize treatment. | Lee, Won Kee; Chong, Gun Oh; Jeong, Shin Young; Lee, Hyun Jung; Park, Shin-Hyung; Ryu, Jung Min; Choi, Youn Seok; Kang, Sungmin; Koo, Yu-Jin; Lee, Dae Hyung; Kong, Eunjung; Lee, Sang-Woo | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Med Informat, Med Res Collaborat Ctr,Sch Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Obstet & Gynecol, Chilgok Hosp, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Nucl Med, Chilgok Hosp, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Obstet & Gynecol, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Radiat Oncol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu 41944, South Korea; Daegu Catholic Univ, Sch Med, Dept Obstet & Gynecol, Daegu 42472, South Korea; Daegu Catholic Univ, Sch Med, Dept Nucl Med, Daegu 42472, South Korea; Yeungnam Univ, Med Sch & Hosp, Dept Obstet & Gynecol, Daegu 42415, South Korea; Yeungnam Univ, Med Sch & Hosp, Dept Nucl Med, Daegu 42415, South Korea | ; lee, sangwoo/KUD-1906-2024; Park, Shinhyung/LNQ-6428-2024 | 22953484700; 23099068000; 36164032500; 57202930844; 57203275843; 57204547720; 55507132200; 55731422300; 59072938800; 56763032400; 37007708500; 57196249819 | wonlee@knu.ac.kr;gochong@knu.ac.kr;syjeong@knu.ac.kr;obgy1019@hanmail.net;shinhyungpark@knu.ac.kr;medgirl87@naver.com;drcys@cu.ac.kr;kufa77@hanmail.net;yujinkoo@ynu.ac.kr;leebhy@ynu.ac.kr;ejkong@ymc.yu.ac.kr;swleenm@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0.72 | 2025-06-25 | 10 | 11 | risk model; nomogram; locally advanced cervical cancer; F-18-FDG PET; CT; concurrent chemoradiotherapy; prognosis | F-18-FLUORODEOXYGLUCOSE UPTAKE; ONCOLOGY-GROUP; LYMPH-NODES; RECURRENCE; SURVIVAL; CHEMORADIATION; TOMOGRAPHY; NOMOGRAMS; CARCINOMA | <sup>18</sup>F-FDG PET/CT; Concurrent chemoradiotherapy; Locally advanced cervical cancer; Nomogram; Prognosis; Risk model | cisplatin; fluorodeoxyglucose f 18; hemoglobin; squamous cell carcinoma antigen; adult; Article; cancer prognosis; cancer recurrence; cancer staging; cancer survival; chemoradiotherapy; computer assisted tomography; disease free survival; external beam radiotherapy; female; follow up; histology; human; lymph node; lymph node metastasis; measurement accuracy; metabolic parameters; nomogram; nuclear magnetic resonance imaging; overall survival; positron emission tomography-computed tomography; proportional hazards model; radiation dose; retrospective study; risk factor; tumor recurrence; tumor volume; uterine cervix cancer; Wart virus | English | 2020 | 2020-02 | 10.3390/jcm9020427 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Prognostic Factors of COVID-19 Infection in Elderly Patients: A Multicenter Study | The outbreak of the COVID-19 pandemic is a substantial threat to the health of all populations worldwide, and old age is a robust risk factor for poor prognosis of COVID-19 infection. To reduce the fatality rate of COVID-19 infection, further understanding of elderly patients with COVID-19 is necessary. We aimed to investigate the prognostic factors in elderly patients with COVID-19. This was a multicenter and retrospective study. Overall, 340 elderly patients with COVID-19 were enrolled in 3 hospitals in Daegu, South Korea. Death and severe pneumonia requiring oxygen treatment were defined as poor clinical outcomes. Of the patients studied, 15% died and 35.2% were classified as having severe pneumonia. In binary logistic regression analysis, activities of daily living (ADL) impairment, fever during hospitalization, initial infiltration on chest radiograph, and initial increased C-reactive protein (CRP) were significantly associated with severe pneumonia (OR = 5.33, p < 0.001; OR = 3.2, p = 0.002; OR = 2.32, p = 0.044; and OR = 1.33, p < 0.001, respectively). ADL impairment, comorbidity, fever during hospitalization, and initial increased CRP were significantly associated with death (OR = 7.13, p < 0.001; OR = 3.28, p = 0.005; OR = 3.15, p = 0.032, and OR = 1.18, p < 0.001, respectively). ADL impairment, fever, and initial CRP were poor prognostic factors in elderly patients with COVID-19. Understanding these poor prognostic factors is necessary to control the disease in elderly patients. | Hwang, Jihye; Ryu, Ho-Sung; Kim, Hyun Ah; Hyun, Miri; Lee, Ji Yeon; Yi, Hyon-Ah | Keimyung Univ, Dept Neurol, Daegu Dongsan Hosp, Daegu 41931, South Korea; Kyungpook Natl Univ Hosp, Dept Neurol, Daegu 41944, South Korea; Keimyung Univ, Sch Med, Dept Med, Div Infect Dis,Dongsan Hosp, Daegu 42601, South Korea; Keimyung Univ, Sch Med, Dept Neurol, Dongsan Hosp, Daegu 42601, South Korea | 57241916300; 57014206500; 57059615500; 55927698200; 57216774221; 7202719675 | jhhwang0110@gmail.com;ryuhosung138@gmail.com;hyunah1118@dsmc.or.kr;eternity7919@dsmc.or.kr;jirong84@dsmc.or.kr;geschwind@dsmc.or.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 12 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 1.51 | 2025-06-25 | 22 | 27 | COVID-19; SARS-CoV-2; novel coronavirus; elderly; prognosis | COVID-19; Elderly; Novel coronavirus; Prognosis; SARS-CoV-2 | alanine aminotransferase; albumin; antibiotic agent; antimalarial agent; antivirus agent; aspartate aminotransferase; C reactive protein; creatine; glucose; lactate dehydrogenase; steroid; ADL disability; aged; antibiotic therapy; antiviral therapy; Article; artificial ventilation; cerebrovascular accident; clinical outcome; cohort analysis; comorbidity; controlled study; coronavirus disease 2019; coughing; daily life activity; death; dementia; diabetes mellitus; diarrhea; disease association; dyspnea; extracorporeal oxygenation; fatigue; female; fever; geriatric patient; headache; hospitalization; human; hypertension; lung infiltrate; major clinical study; male; myalgia; nausea; oxygen therapy; pneumonia; prognosis; real time reverse transcription polymerase chain reaction; renal replacement therapy; respiratory distress; retrospective study; rhinorrhea; sore throat; South Korea; thorax pain; thorax radiography; urea nitrogen blood level; vomiting | English | 2020 | 2020-12 | 10.3390/jcm9123932 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Remission of Proteinuria May Protect against Progression to Chronic Kidney Disease in Pediatric-Onset IgA Nephropathy | Immunoglobulin A nephropathy (IgAN) is one of the most common primary glomerulopathies diagnosed in children and adolescents. This study aimed to evaluate the clinical features in and outcomes of pediatric IgAN over the last 30 years. Patients who were diagnosed before age of 18 at 20 centers in Korea were evaluated retrospectively. Of the 1154 patients (768 males, 386 females) with a median follow-up of 5 years, 5.6% (n= 65) progressed to stage 3-5 chronic kidney disease (CKD). The 10- and 20-year CKD-free survival rates were 91.2% and 75.6%, respectively. Outcomes did not differ when comparing those in Korea who were diagnosed prior to versus after the year 2000. On multivariate analysis, combined asymptomatic hematuria and proteinuria as presenting symptoms and decreased renal function at the time of biopsy were associated with progression to CKD, while remission of proteinuria was negatively associated with this outcome. Patients who presented with gross hematuria or nephrotic syndrome tended toward positive outcomes, especially if they ultimately achieved remission. While remission of proteinuria might imply that the disease is inherently less aggressive, it also can be achieved by management. Therefore, more aggressive management might be required for pediatric-onset IgAN. | Suh, Jin-Soon; Jang, Kyung Mi; Hyun, Hyesun; Cho, Myung Hyun; Lee, Joo Hoon; Park, Young Seo; Oh, Jae Hyuk; Kim, Ji Hong; Yoo, Kee Hwan; Chung, Woo Yeong; Kim, Seong Heon; Kim, Keehyuck; Lee, Dae Yeol; Lee, Jung Won; Cho, Min Hyun; Park, Hyewon; Koo, Ja Wook; Han, Kyoung Hee; Yang, Eun Mi; Lee, Keum Hwa; Shin, Jae Il; Cho, Heeyeon; Kim, Kyo Soon; Ha, Il-Soo; Park, Yong Hoon; Kang, Hee Gyung | Catholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Dept Pediat, Bucheon 14647, South Korea; Yeungnam Univ Hosp, Daegu 42415, South Korea; Catholic Univ Korea, St Vincents Hosp, Coll Med, Suwon 16247, South Korea; Hallym Univ, Sacred Heart Hosp, Anyang 14068, South Korea; Univ Ulsan, Childrens Hosp, Asan Med Ctr, Coll Med, Seoul 05505, South Korea; Ajou Univ Hosp, Sch Med, Suwon 16499, South Korea; Yonsei Univ, Dept Pediat, Coll Med, Seoul 03722, South Korea; Korea Univ, Guro Hosp, Seoul 08308, South Korea; Inje Univ, Busan Paik Hosp, Coll Med, Busan 47392, South Korea; Pusan Natl Univ, Childrens Hosp, Yangsan 50612, South Korea; Natl Hlth Insurance Serv Ilsan Hosp, Goyang 10444, South Korea; Jeonbuk Natl Univ Hosp, Jeonju 54907, South Korea; Ewha Womans Univ, Seoul Hosp, Seoul 07804, South Korea; Kyungpook Natl Univ, Sch Med, Daegu 41944, South Korea; Seoul Natl Univ, Bundang Hosp, Seongnam 13620, South Korea; Inje Univ, Sanggye Paik Hosp, Seoul 01757, South Korea; Jeju Natl Univ, Sch Med, Jeju 63243, South Korea; Chonnam Natl Univ Hosp, Hwasun 58128, South Korea; Med Sch, Hwasun 58128, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea; Konkuk Univ Hosp, Seoul 05029, South Korea; Seoul Natl Univ, Coll Med, Seoul 03080, South Korea; Seoul Natl Univ, Childrens Hosp, Seoul 03080, South Korea | ; SHIN, JAE IL/J-6922-2017; Lee, Dae Young/ADO-9686-2022; Lee, Yong Jae/GLR-4153-2022; Kim, Seong/AAD-8853-2020; Kim, Dong Ki/J-5389-2012; Lee, Seok/ABF-7548-2020; cho, myung hyun/AEB-7941-2022; Suh, Jin-Soon/GNH-6543-2022; Kim, Jung/L-9791-2019 | 35222513700; 57203762745; 57204538255; 57203276948; 37112404100; 56701214400; 57246559600; 36062363200; 7202592702; 8605959600; 57213778393; 7409325956; 35074385100; 26028875500; 7401727726; 59110223200; 26221103500; 58389645900; 56665095200; 57193231590; 57964880100; 15724272900; 57246966000; 7005904938; 57246642900; 7404071546 | rebekahjs@hanmail.net;fortune001j@gmail.com;inthy@naver.com;dong82dong82@naver.com;pedkid@gmail.com;yspark@amc.seoul.kr;ssacktung@naver.com;KKKJHD@yuhs.ac;guroped@korea.ac.kr;chungwy@korea.com;pedksh@gmail.com;kkim@nhimc.or.kr;leedy@jbnu.ac.kr;happymaniajw@hanmail.net;chomh@knu.ac.kr;ghyewon@gmail.com;koojw9@paik.ac.kr;hansyang78@gmail.com;nuts99@naver.com;AZSAGM@yuhs.ac;SHINJI@yuhs.ac;heeyeon1.cho@samsung.com;kimkyo@kuh.ac.kr;ilsooha@snu.ac.kr;yhpark@medical.yu.ac.kr;kanghg@snu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 7 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0.64 | 2025-06-25 | 14 | 13 | children; IgA nephropathy; long-term outcome; remission of proteinuria | OXFORD CLASSIFICATION; NEPHROTIC SYNDROME; JAPANESE CHILDREN; RISK-FACTORS; PROGNOSIS; FEATURES; EPIDEMIOLOGY; PREVALENCE; PREDICTORS; GENETICS | Children; IgA nephropathy; Long-term outcome; Remission of proteinuria | albumin; immunosuppressive agent; adolescent; Article; child; chronic kidney failure; clinical outcome; disease exacerbation; disease free survival; end stage renal disease; estimated glomerular filtration rate; female; follow up; glomerulonephritis; hematuria; human; human tissue; immunoglobulin A nephropathy; kidney biopsy; kidney failure; kidney function; major clinical study; male; nephrotic syndrome; pathology; proliferative glomerulonephritis; protein to creatinine ratio; proteinuria; recurrence risk; remission; renal replacement therapy; renin angiotensin aldosterone system; risk factor; urinalysis; urinary tract infection | English | 2020 | 2020-07 | 10.3390/jcm9072058 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Revealing a Transformation-Induced Plasticity (TRIP) Phenomenon in a Medium-Entropy Alloy | A transformation-induced plasticity phenomenon in Fe-65(CoCrMnNi)(35)medium-entropy alloy was investigated. According to the X-ray diffraction patterns, the as-cast specimen contains a single-phase face-centered cubic (fcc), while low-temperature annealing at 500 degrees C and 600 degrees C leads to the introduction of a body-centered cubic (bcc) phase as a secondary phase. Further increment of the annealing temperature to above 700 degrees C eliminates the bcc phase, and the microstructure was found to contain a single-phase fcc. At 20% true strain, an fcc-to-bcc phase transformation is observed; whereas, at 28% true strain, an fcc-to-hcp phase transformation takes place as an additional deformation mechanism. This strain-induced phase transformation phenomenon leads to improved tensile properties of this alloy. | Ondicho, Ibrahim; Alunda, Bernard; Owino, Dicken; Otieno, Luke; Chepkoech, Melody | Dedan Kimathi Univ Technol, Dept Mech Engn, Private Bag 10143, Nyeri, Kenya; Dedan Kimathi Univ Technol, Mat Design & Mfg MADEMA Grp, Private Bag 10143, Dedan Kimathi, Nyeri, Kenya; Yuengnam Univ, Dept Adv Root Ind Engn, Gyongsan, South Korea; Taita Taveta Univ, Dept Min & Minerals Proc Engn, POB 635-80300, Voi, Kenya; Inha Univ, Dept Mech Engn, Incheon, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu, South Korea; Howard Univ, Dept Mech Engn, Washington, DC 20059 USA | ; Ondicho, Ibrahim/AAJ-5960-2020; Otieno, Luke/KHW-8698-2024 | 57205095162; 55354745500; 57217184530; 57205578290; 57200114147 | ibrahim.ondicho@dkut.ac.ke; | ACTA METALLURGICA SINICA-ENGLISH LETTERS | ACTA METALL SIN-ENGL | 1006-7191 | 2194-1289 | 33 | 8 | SCIE | METALLURGY & METALLURGICAL ENGINEERING | 2020 | 2.755 | 23.1 | 0.23 | 2025-06-25 | 7 | 8 | Phase transformation; X-ray diffraction; Mechanical behavior; Microstructure evolution; Multicomponent alloys | PHASE-STABILITY; MECHANICAL-PROPERTIES; SINGLE-PHASE; ORIENTATION | Mechanical behavior; Microstructure evolution; Multicomponent alloys; Phase transformation; X-ray diffraction | Phase transitions; Plasticity; Temperature; Annealing temperatures; Body-centered-cubic phase; Deformation mechanism; Face-centered cubic; Low temperature annealing; Secondary phase; Strain-induced phase transformation; Transformation induced plasticity; Entropy | English | 2020 | 2020-08 | 10.1007/s40195-020-01088-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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