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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Ultra-Miniature Circularly Polarized CPW-Fed Implantable Antenna Design and its Validation for Biotelemetry Applications | The paper presents a coplanar waveguide (CPW)-fed ultra-miniaturized patch antenna operating in Industrial, Scientific and Medical (ISM) band (2.4-2.5GHz) for biotelemetry applications. The proposed antenna structure is circular in shape and its ground plane is loaded with a pair of slots for obtaining circular polarization. In the proposed design, asymmetric square slots generate phase condition for right-hand circularly polarized (RHCP) radiation. And, by merely changing the position of the slots, either RHCP or left-hand circularly polarized (LHCP) radiation can be excited. In the proposed design, a meandered central strip is used for miniaturization. The simulations of the proposed antenna are carried out using Ansys HFSS software with a single-layer and multilayer human tissue models. The antenna shows good performance for different tissue properties owing to its wide axial ratio bandwidth and impedance bandwidth. The antenna is fabricated and measurements are carried out in skin mimicking phantom and pork. Simulated and measured performances of the antenna are in close agreement. The power link budget is also calculated using an exterior circularly polarized (CP) receiving antenna. | Kaim, Vikrant; Kanaujia, Binod Kumar; Kumar, Sachin; Choi, Hyun Chul; Kim, Kang Wook; Rambabu, Karumudi | Jawaharlal Nehru Univ, Sch Computat & Integrat Sci, New Delhi 110067, India; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Univ Alberta, Dept Elect & Comp Engn, Edmonton, AB T6G 2V4, Canada | kanaujia, Binod/L-6484-2019; Kanaujia, Binod/L-6484-2019; Kumar, Sachin/W-2211-2019 | 57204075245; 56962785800; 56907994000; 57193342681; 57204432422; 24171880600 | kang_kim@ee.knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 1.81 | 2025-06-25 | 43 | 61 | CAPSULE ANTENNA; SLOT ANTENNA; TELEMETRY; SKIN; COMMUNICATION | English | 2020 | 2020-04-22 | 10.1038/s41598-020-63780-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Velvet activated McrA plays a key role in cellular and metabolic development in Aspergillus nidulans | McrA is a key transcription factor that functions as a global repressor of fungal secondary metabolism in Aspergillus species. Here, we report that mcrA is one of the VosA-VelB target genes and McrA governs the cellular and metabolic development in Aspergillus nidulans. The deletion of mcrA resulted in a reduced number of conidia and decreased mRNA levels of brlA, the key asexual developmental activator. In addition, the absence of mcrA led to a loss of long-term viability of asexual spores (conidia), which is likely associated with the lack of conidial trehalose and increased beta-(1,3)-glucan levels in conidia. In supporting its repressive role, the mcrA deletion mutant conidia contain more amounts of sterigmatocystin and an unknown metabolite than the wild type conidia. While overexpression of mcrA caused the fluffy-autolytic phenotype coupled with accelerated cell death, deletion of mcrA did not fully suppress the developmental defects caused by the lack of the regulator of G-protein signaling protein FlbA. On the contrary to the cellular development, sterigmatocystin production was restored in the Delta flbA Delta mcrA double mutant, and overexpression of mcrA completely blocked the production of sterigmatocystin. Overall, McrA plays a multiple role in governing growth, development, spore viability, and secondary metabolism in A. nidulans. | Lee, Mi-Kyung; Son, Ye-Eun; Park, Hee-Soo; Alshannaq, Ahmad; Han, Kap-Hoon; Yu, Jae-Hyuk | Korea Res Inst Biosci & Biotechnol KRIBB, Biol Resource Ctr, Jellobuk Do 56212, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Univ Wisconsin, Dept Bacteriol, 1550 Linden Dr, Madison, WI 53706 USA; Woosuk Univ, Dept Pharmaceut Engn, Wonju 55338, South Korea; Konkuk Univ, Dept Syst Biotechnol, Seoul 05030, South Korea | ; Yu, Jae-Hyuk/A-2343-2008; Park, Hee-Soo/AAC-6422-2019 | 57221217721; 57200513491; 15751448400; 57194569216; 22947495900; 7405531243 | jyu1@wisc.edu; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.23 | 2025-06-25 | 10 | 10 | ASEXUAL SPORULATION; SECONDARY METABOLISM; REGULATOR; BRLA; AUTOLYSIS; ASSAY; ABAA | Aspergillus nidulans; Fungal Proteins; Gene Deletion; Spores, Fungal; Sterigmatocystin; Transcription Factors; fungal protein; sterigmatocystin; transcription factor; Aspergillus nidulans; biosynthesis; fungus spore; gene deletion; genetics; metabolism | English | 2020 | 2020-09-15 | 10.1038/s41598-020-72224-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Directionality of growth and kinetics of branched fibril formation | The self-assembly of fibrils is a subject of intense interest, primarily due to its relevance to the formation of pathological structures. Some fibrils develop branches via the so-called secondary nucleation. In this paper, we use the master equation approach to model the kinetics of formation of branched fibrils. In our model, a branched fibril consists of one mother branch and several daughter branches. We consider five basic processes of fibril formation, namely, nucleation, elongation, branching, fragmentation, and dissociation of the primary nucleus of fibrils into free monomers. Our main focus is on the effect of the directionality of growth on the kinetics of fibril formation. We consider several cases. At first, the mother branch may elongate from one or from both ends, while the daughter branch elongates only from one end. We also study the case of branched fibrils with bidirectionally growing daughter branches, tangentially to the main stem, which resembles the intertwining process. We derive a set of ordinary differential equations for the moments of the number concentration of fibrils, which can be solved numerically. Assuming that the primary nucleus of fibrils dissociates with the fragmentation rate, in the limit of the zero branching rate, our model reproduces the results of a previous model that considers only the three basic processes of nucleation, elongation, and fragmentation. We also use the experimental parameters for the fibril formation of Huntingtin fragments to investigate the effect of unidirectional vs bidirectional elongation of the filaments on the kinetics of fibrillogenesis. | Razbin, Mohammadhosein; Benetatos, Panayotis; Mirabbaszadeh, Kavoos | Amirkabir Univ Technol, Dept Energy Engn & Phys, Tehran 14588, Iran; Kyungpook Natl Univ, Dept Phys, 80 Daehakro, Daegu 41566, South Korea | Razbin, Dr. rer. nat. Mohammadhosein/P-1405-2019; Razbin, Mohammadhosein/P-1405-2019; Benetatos, Panayotis/AAT-5957-2021 | 56324403700; 6507575810; 13102723100 | m.razbin@aut.ac.ir;pben@knu.ac.kr;mirabbas@aut.ac.ir; | JOURNAL OF CHEMICAL PHYSICS | J CHEM PHYS | 0021-9606 | 1089-7690 | 153 | 24 | SCIE | CHEMISTRY, PHYSICAL;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2020 | 3.488 | 23.0 | 0.22 | 2025-06-25 | 3 | 4 | SECONDARY NUCLEATION; AMYLOID FORMATION; PROTEIN; ACTIN; POLYMERIZATION; ASSOCIATION; MECHANISM; REVEALS; DISEASE; PHASE | Amyloid; Kinetics; Models, Molecular; Protein Aggregates; Protein Structure, Secondary; Crystallization; Elongation; Kinetics; Nucleation; Ordinary differential equations; amyloid; protein aggregate; Branching rate; Experimental parameters; Fibril formation; Fibrillogenesis; Master equations; Number concentration; Pathological structures; Secondary nucleation; chemistry; kinetics; molecular model; protein secondary structure; Growth kinetics | English | 2020 | 2020-12-28 | 10.1063/5.0029142 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Green's function of the Smoluchowski equation with reaction sink: Application to geminate and bulk recombination reactions | By applying a recently developed solution method for the Fredholm integral equation of the second kind, we obtain an expression for Green's function of the Smoluchowski equation with a reaction sink. The result is applied to obtain accurate analytical expressions for the time-dependent survival probability of a geminate reactant pair and the rate coefficient of the bulk recombination between reactants undergoing diffusive motions under strong Coulomb interactions. The effects of both repulsive and attractive interactions are considered, and the results are compared with the numerical results obtained by solving the equation for the survival probability and the nonequilibrium pair correlation function. It is shown that the solutions are accurate enough for most reasonable parameter values. | Lee, Kyusup; Sung, Jaeyoung; Choi, Cheol Ho; Lee, Sangyoub | Seoul Natl Univ, Dept Chem, Seoul 08826, South Korea; Chung Ang Univ, Dept Chem, Seoul 06974, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea | Choi, Cheol Ho/AAA-4705-2020 | 56595371700; 7402626837; 7402958948; 7601392651 | sangyoub@snu.ac.kr; | JOURNAL OF CHEMICAL PHYSICS | J CHEM PHYS | 0021-9606 | 1089-7690 | 152 | 13 | SCIE | CHEMISTRY, PHYSICAL;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2020 | 3.488 | 23.0 | 0.37 | 2025-06-25 | 5 | 5 | LONG-TIME BEHAVIOR; IRREVERSIBLE REACTIONS; OBSERVABLES | Physical chemistry; Physics; Analytical expressions; Attractive interactions; Bulk recombination; Diffusive motions; Fredholm integral equations; Pair correlation functions; Smoluchowski equation; Survival probabilities; Integral equations | English | 2020 | 2020-04-07 | 10.1063/1.5144269 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Nitric oxide-inducing Genistein elicits apoptosis-like death via an intense SOS response in Escherichia coli | Increasing prevalence of multidrug-resistant untreatable infections has prompted researchers to trial alternative treatments such as a substitute for traditional antibiotics. This study endeavored to elucidate the antibacterial mechanism(s) of this isoflavone, via analysis of relationship between genistein and Escherichia coli. Furthermore, this investigation analyzed whether genistein generates nitric oxide (NO) in E. coli as NO contributes to cell death. RecA, an essential protein for the bacterial SOS response, was detected through western blot, and the activated caspases decreased without RecA. The results showed that the NO induced by genistein affected the bacterial DNA. Under conditions of acute DNA damage, an SOS response called apoptosis-like death occurred, affecting DNA repair. These results suggested that RecA was bacterial caspase-like protein. In addition, NO was toxic to the bacterial cells and induced dysfunction of the plasma membrane. Thus, membrane depolarization and phosphatidylserine exposure were observed similarly to eukaryotic apoptosis. In conclusion, the combined results demonstrated that the antibacterial mode of action(s) of genistein was a NO-induced apoptosis-like death, and the role of RecA suggested that it contributed to the SOS response of NO defense. Key points Genistein generates nitric oxide in E. coli. Genistein exhibits intense SOS response in E. coli. Genistein-induced NO causes apoptosis-like death in E. coli. | Kim, Heesu; Lee, Dong Gun | Kyungpook Natl Univ, Sch Life Sci, Plus KNU Creat BioRes Grp BK21, Daegu 41566, South Korea | Lee, Dong-Gun/IWD-9833-2023 | 57219859173; 55668060900 | dglee222@knu.ac.kr; | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | APPL MICROBIOL BIOT | 0175-7598 | 1432-0614 | 104 | 24 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2020 | 4.813 | 23.0 | 0.82 | 2025-06-25 | 17 | 17 | Genistein; Escherichia coli; Bacterial apoptosis-like death; Nitric oxide; RecA | ANTIBACTERIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; ANTIBIOTIC-RESISTANCE; TOPOISOMERASE-IV; DNA GYRASE; OXIDATIVE STRESS; NATURAL-PRODUCTS; INHIBITION; CELLS; ISOFLAVONE | Bacterial apoptosis-like death; Escherichia coli; Genistein; Nitric oxide; RecA | Apoptosis; Escherichia coli; Escherichia coli Proteins; Genistein; Nitric Oxide; Rec A Recombinases; SOS Response, Genetics; Bacteria (microorganisms); Escherichia coli; Eukaryota; Cell death; Cell membranes; DNA; Escherichia coli; Nitric oxide; Proteins; bacterial DNA; caspase; genistein; n(g) nitroarginine methyl ester; nitric oxide; norfloxacin; oxygen; peroxynitrite; phosphatidylserine; RecA protein; Escherichia coli protein; genistein; nitric oxide; RecA protein; Antibacterial mechanisms; Bacterial cells; Essential proteins; Induced apoptosis; Membrane depolarization; Mode of action; Multidrug resistants; Phosphatidylserine; apoptosis; coliform bacterium; drug resistance; induced response; nitric oxide; plasma; protein; antibacterial activity; antibiotic resistance; antimicrobial activity; apoptosis; Article; bacterial cell; chromosome condensation; DNA damage; DNA fragmentation; DNA repair; Escherichia coli; membrane depolarization; minimum inhibitory concentration; nonhuman; protein expression; sos response (genetics); Western blotting; apoptosis; genetics; metabolism; Flavonoids | English | 2020 | 2020-12 | 10.1007/s00253-020-11003-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Xylose utilization in Saccharomyces cerevisiae during conversion of hydrothermally pretreated lignocellulosic biomass to ethanol | With growing interest in alternative fuels to minimize carbon and particle emissions, research continues on the production of lignocellulosic ethanol and on the development of suitable yeast strains. However, great diversities and continued technical advances in pretreatment methods for lignocellulosic biomass complicate the evaluation of developed yeast strains, and strain development often lags industrial applicability. In this review, recent studies demonstrating developed yeast strains with lignocellulosic biomass hydrolysates are compared. For the pretreatment methods, we highlight hydrothermal pretreatments (dilute acid treatment and autohydrolysis), which are the most commonly used and effective methods for lignocellulosic biomass pretreatment. Rather than pretreatment conditions, the type of biomass most strongly influences the composition of the hydrolysates. Metabolic engineering strategies for yeast strain development, the choice of xylose-metabolic pathway, adaptive evolution, and strain background are highlighted as important factors affecting ethanol yield and productivity from lignocellulosic biomass hydrolysates. A comparison of the parameters from recent studies demonstrating lignocellulosic ethanol production provides useful information for future strain development. | Park, Heeyoung; Jeong, Deokyeol; Shin, Minhye; Kwak, Suryang; Oh, Eun Joong; Ko, Ja Kyong; Kim, Soo Rin | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 08826, South Korea; Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA; Univ Colorado, Renewable & Sustainable Energy Inst RASEI, Boulder, CO 80303 USA; KIST, Clean Energy Res Ctr, Seoul 02792, South Korea | Jeong, Deokyeol/GLR-8021-2022; Kwak, Suryang/AAF-7489-2020; Kim, Soo Rin/X-2192-2019 | 57211334915; 57191332457; 57208401604; 56523999400; 59716734900; 56603594800; 36659584200 | jkko@kist.re.kr;soorinkim@knu.ac.kr; | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | APPL MICROBIOL BIOT | 0175-7598 | 1432-0614 | 104 | 8 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2020 | 4.813 | 23.0 | 0.57 | 2025-06-25 | 25 | 28 | Saccharomyces cerevisiae; Xylose isomerase; Xylose reductase; Acetic acid; Hardwoods; Agricultural residues | HOT-WATER PRETREATMENT; ENZYMATIC-HYDROLYSIS; SIMULTANEOUS SACCHARIFICATION; EFFICIENT HYDROLYSIS; CELLULOSIC ETHANOL; YEAST; FERMENTATION; BIOETHANOL; LIGNIN; TECHNOLOGIES | Acetic acid; Agricultural residues; Hardwoods; Saccharomyces cerevisiae; Xylose isomerase; Xylose reductase | Biomass; Ethanol; Fermentation; Hydrolysis; Lignin; Metabolic Engineering; Metabolic Networks and Pathways; Saccharomyces cerevisiae; Xylose; Saccharomyces cerevisiae; Acetic acid; Agricultural wastes; Alternative fuels; Bioethanol; Biomass; Cellulosic ethanol; Ethanol; Hardwoods; Metabolic engineering; Metabolism; Yeast; acetic acid derivative; alcohol; bioethanol; cellulase; hemicellulose; hydrolase; lignin; lignocellulose; xylose; alcohol; lignocellulose; xylose; Lignocellulosic biomass pretreatment; Lignocellulosic ethanols; Particle emissions; Pretreatment conditions; Pretreatment methods; Xylose isomerase; Xylose reductase; Xylose utilizations; acetic acid; biomass; cellulose; crop residue; enzyme; enzyme activity; ethanol; hydrothermal system; metabolism; wood; yeast; autohydrolysis; biofuel production; biomass; biomass conversion; chemical composition; dilute acid treatment; dilution; fermentation; fungal strain; hydrolysis; metabolic engineering; metabolism; molecular evolution; nonhuman; physical parameters; Review; Saccharomyces cerevisiae; standard; hydrolysis; procedures; Saccharomyces cerevisiae; Lignocellulosic biomass | English | 2020 | 2020-04 | 10.1007/s00253-020-10427-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke | Acute kidney injury (AKI) is often associated with the use of contrast agents. We evaluated the frequency of AKI, factors associated with AKI after endovascular treatment (EVT), and associations with AKI and clinical outcomes. We retrospectively analyzed consecutively enrolled patients with acute ischemic stroke who underwent EVT at three stroke centers in Korea. We compared the characteristics of patients with and without AKI and independent factors associated with AKI after EVT. We also investigated the effects of AKI on functional outcomes and mortality at 3 months. Of the 601 patients analyzed, 59 patients (9.8%) developed AKI and five patients (0.8%) started renal replacement therapy after EVT. In the multivariate analysis, diabetes mellitus (odds ratio (OR), 2.341; 95% CI, 1.283-4.269; p = 0.005), the contrast agent dose (OR, 1.107 per 10 mL; 95% CI, 1.032-1.187; p = 0.004), and unsuccessful reperfusion (OR, 1.909; 95% CI, 1.019-3.520; p = 0.040) were independently associated with AKI. The presence of AKI was associated with a poor functional outcome (OR, 5.145; 95% CI, 2.177-13.850; p < 0.001) and mortality (OR, 8.164; 95% CI, 4.046-16.709; p < 0.001) at 3 months. AKI may also affect the outcomes of ischemic stroke patients undergoing EVT. When implementing EVT, practitioners should be aware of these risk factors. | Yoo, Joonsang; Hong, Jeong-Ho; Lee, Seong-Joon; Kim, Yong-Won; Hong, Ji Man; Kim, Chang-Hyun; Choi, Jin Wook; Kang, Dong-Hun; Kim, Yong-Sun; Hwang, Yang-Ha; Lee, Jin Soo; Sohn, Sung-Il | Keimyung Univ, Dept Neurol, Sch Med, Daegu 42601, South Korea; Ilsan Hosp, Natl Hlth Insurance Serv, Dept Neurol, Goyang 10444, South Korea; Ajou Univ, Sch Med, Dept Neurol, Suwon 16500, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu 41944, South Korea; Keimyung Univ, Dept Neurosurg, Sch Med, Daegu 42601, South Korea; Ajou Univ, Dept Radiol, Sch Med, Suwon 16500, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu 41944, South Korea | Kim, Chang-Hyun/I-5166-2012; Hong, Jeong-Ho/T-8099-2018; Hong, Ji Man/AAE-2686-2022; Hong, Jeong-Ho/AAE-1002-2022; HWANG, Yang-Ha/F-3068-2013 | 55261162200; 55931654800; 57218256679; 56203298200; 55729426200; 56059033400; 55722501000; 8977805800; 57095278300; 7402311308; 55963063300; 36479287000 | quarksea@gmail.com;neurohong79@gmail.com;editisan@hanmail.net;yw.kim23@gmail.com;dacda@hanmail.net;ppori2k@naver.com;radjwchoi@gmail.com;kdhdock@hotmail.com;yongkim@knu.ac.kr;yangha.hwang@gmail.com;jinsoo22@gmail.com;sungil.sohn@gmail.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 5 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0.8 | 2025-06-25 | 17 | 17 | ischemic stroke; acute kidney injury; contrast media; endovascular treatment; outcome | CONTRAST-INDUCED NEPHROPATHY; PERCUTANEOUS CORONARY INTERVENTION; ACUTE-RENAL-FAILURE; RISK-FACTORS; METAANALYSIS; ANGIOGRAPHY; SAFETY; PNEUMONIA; OCCLUSION; OUTCOMES | Acute kidney injury; Contrast media; Endovascular treatment; Ischemic stroke; Outcome | contrast medium; creatinine; iodixanol; iopamidol; pamiray; tissue plasminogen activator; acute kidney failure; adult; aged; angioplasty; Article; brain angiography; brain ischemia; clinical outcome; computed tomographic angiography; computer assisted tomography; endovascular surgery; estimated glomerular filtration rate; female; hemodialysis; human; kidney function; major clinical study; male; middle aged; mortality; National Institutes of Health Stroke Scale; Rankin scale; renal replacement therapy; reperfusion; retrospective study; risk factor | English | 2020 | 2020-05 | 10.3390/jcm9051471 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Admission Hyperglycemia as a Predictor of Mortality in Acute Heart Failure: Comparison between the Diabetics and Non-Diabetics | Background: To investigate the impact of admission hyperglycemia (HGL) on in-hospital death (IHD) and 1-year mortality in acute heart failure (AHF) patients with or without diabetes mellitus (DM). Methods: Among 5625 AHF patients enrolled in a nationwide registry, 5541 patients were divided into four groups based on the presence of admission HGL and diabetes mellitus (DM). Admission HGL was defined as admission glucose level > 200 mg/dL. IHD and 1-year mortality were compared. Results: IHD developed in 269 patients (4.9%), and 1-year death developed in 1220 patients (22.2%). DM was a significant predictor of 1-year death (24.8% in DM vs. 20.5% in non-DM, p < 0.001), but not for IHD. Interestingly, admission HGL was a significant predictor of both IHD (7.6% vs. 4.2%, p < 0.001) and 1-year death (26.2% vs. 21.3%, p = 0.001). Admission HGL was a significant predictor of IHD in both DM and non-DM group, whereas admission HGL was a significant predictor of 1-year death only in non-DM (27.8% vs. 19.9%, p = 0.003), but not in DM group. In multivariate analysis, admission HGL was an independent predictor of 1-year mortality in non-DM patients (HR 1.32, 95% CI 1.03-1.69, p = 0.030). Conclusion: Admission HGL was a significant predictor of IHD and 1-year death in patients with AHF, whereas DM was only a predictor of 1-year death. Admission HGL was an independent predictor of 1-year mortality in non-DM patients with AHF, but not in DM patients. Careful monitoring and intensive medical therapy should be considered in AHF patients with admission HGL, regardless of DM. | Cho, Jae Yeong; Kim, Kye Hun; Lee, Sang Eun; Cho, Hyun-Jai; Lee, Hae-Young; Choi, Jin-Oh; Jeon, Eun-Seok; Kim, Min-Seok; Kim, Jae-Joong; Hwang, Kyung-Kuk; Chae, Shung Chull; Baek, Sang Hong; Kang, Seok-Min; Choi, Dong-Ju; Yoo, Byung-Su; Ahn, Youngkeun; Park, Hyun-Young; Cho, Myeong-Chan; Oh, Byung-Hee | Chonnam Natl Univ, Med Sch Hosp, Dept Cardiovasc Med, 42 Jebong Ro, Gwangju 61469, South Korea; Univ Ulsan, Coll Med, Div Cardiol, Seoul 05505, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul 03080, South Korea; Sungkyunkwan Univ, Coll Med, Div Cardiol, Seoul 06351, South Korea; Chungbuk Natl Univ, Coll Med, Dept Cardiol, Cheongju 28644, South Korea; Kyungpook Natl Univ, Coll Med, Dept Cardiol, Daegu 41944, South Korea; Catholic Univ Korea, Dept Cardiovasc Med, Seoul 06591, South Korea; Yonsei Univ, Coll Med, Dept Cardiol, Seoul 03722, South Korea; Seoul Natl Univ, Bundang Hosp, Div Cardiol, Seongnam 13620, South Korea; Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju 26426, South Korea; Natl Inst Hlth NIH, Osong 28159, South Korea | ; Cho, Jae Yeong/GVT-2986-2022; Choi, Joon/D-6140-2017; Oh, Byung-Hee/G-9875-2011; LEE, JI/L-6920-2013; Lee, Hye-Young/JEP-8044-2023; Kim, Kyung-Hee/JBI-8300-2023; Kim, Soo-Yeon/ADR-9663-2022; Jeong, Gi/AAB-2830-2021; Choi, Dong-Ju/J-5686-2012 | 23024350000; 56150430800; 57207065107; 35285421400; 56151235500; 15848011800; 7004279641; 57212315719; 36065764100; 7402426370; 7101962036; 7201371594; 7405685375; 35274349200; 7102851884; 56937721300; 57221233516; 7401727518; 57216293873 | jaeyeongcho@gmail.com;cvkimkh@gmail.com;sangeunlee.md@gmail.com;hyunjaicho@snu.ac.kr;hylee612@snu.ac.kr;choijean5@gmail.com;eunseok.jeon@samsung.com;guess124@gmail.com;jjkim@amc.seoul.kr;kyungkukhwang@gmail.com;scchae@knu.ac.kr;whitesh@catholic.ac.kr;smkang@yumc.yonsei.ac.kr;djchoi@snubh.org;yubs@yonsei.ac.kr;cecilyk@hanmail.net;hypark65@nih.go.kr;mccho@chungbuk.ac.kr;ohbhmed@snu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0.96 | 2025-06-25 | 11 | 16 | acute heart failure; hyperglycemia; diabetes mellitus; mortality | BLOOD-GLUCOSE LEVEL; ACUTE MYOCARDIAL-INFARCTION; IN-HOSPITAL MORTALITY; LONG-TERM MORTALITY; CLINICAL CHARACTERISTICS; INSULIN-RESISTANCE; ELDERLY-PATIENTS; IMPACT; ASSOCIATION; MELLITUS | Acute heart failure; Diabetes mellitus; Hyperglycemia; Mortality | acetylsalicylic acid; beta adrenergic receptor blocking agent; C reactive protein; digoxin; dipeptidyl carboxypeptidase inhibitor; furosemide; glucose; hemoglobin A1c; hydroxymethylglutaryl coenzyme A reductase inhibitor; insulin; acute heart failure; age; aged; Article; atrial fibrillation; body mass; cardiovascular mortality; cardiovascular parameters; cohort analysis; controlled study; diabetes mellitus; Doppler echocardiography; dyslipidemia; echocardiography; female; follow up; glomerulus filtration rate; glucose blood level; heart left ventricle ejection fraction; heart rate; high risk population; hospital admission; hospital mortality; hospital readmission; hospitalization; human; hyperglycemia; hypertension; insulin sensitivity; ischemic heart disease; kidney failure; left atrium dimension; left ventricular end diastolic dimension; left ventricular end systolic dimension; lung congestion; major clinical study; male; prevalence; renin angiotensin aldosterone system; sex difference; survival analysis; survival rate; systolic blood pressure; valvular heart disease | English | 2020 | 2020-01 | 10.3390/jcm9010149 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Arginase 2 Deficiency Promotes Neuroinflammation and Pain Behaviors Following Nerve Injury in Mice | Microglia, the resident macrophages, act as the first and main form of active immune defense in the central nervous system. Arginase 2 (Arg2) is an enzyme involved in L-arginine metabolism and is expressed in macrophages and nervous tissue. In this study, we determined whether the absence of Arg2 plays a beneficial or detrimental role in the neuroinflammatory process. We then investigated whether the loss of Arg2 potentiated microglia activation and pain behaviors following nerve injury-induced neuropathic pain. A spinal nerve transection (SNT) experimental model was used to induce neuropathic pain in mice. As a result of the peripheral nerve injury, SNT induced microgliosis and astrogliosis in the spinal cord, and upregulated inflammatory signals in both wild-type (WT) and Arg2 knockout (KO) mice. Notably, inflammation increased significantly in the Arg2 KO group compared to the WT group. We also observed a more robust microgliosis and a lower mechanical threshold in the Arg2 KO group than those in the WT group. Furthermore, our data revealed a stronger upregulation of M1 pro-inflammatory cytokines, such as interleukin (IL)-1 beta, and a stronger downregulation of M2 anti-inflammatory cytokines, including IL4 and IL-10, in Arg2 KO mice. Additionally, stronger formation of enzyme-inducible nitric oxide synthase, oxidative stress, and decreased expression of CD206 were detected in the Arg2 KO group compared to the WT group. These results suggest that Arg2 deficiency contributes to inflammatory response. The reduction or the loss of Arg2 results in the stronger neuroinflammation in the spinal dorsal horn, followed by more severe pain behaviors arising from nerve injury-induced neuropathic pain. | Yin, Yuhua; Thuy Linh Pham; Shin, Juhee; Shin, Nara; Kang, Dong-Wook; Lee, Sun Yeul; Lee, Wonhyung; Kim, Cuk-Seong; Kim, Sang Ryong; Hong, Jinpyo; Kim, Dong-Woon | Chungnam Natl Univ, Sch Med, Dept Med Sci, Daejeon 35015, South Korea; Chungnam Natl Univ, Sch Med, Dept Anat & Cell Biol, Brain Res Inst, Daejeon 35015, South Korea; Chungnam Natl Univ, Sch Med, Dept Physiol, Daejeon 35015, South Korea; Chungnam Natl Univ Hosp, Dept Anesthesia & Pain Med, Daejeon 35015, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Inst Life Sci & Biotechnol,Brain Sci & Engn Inst, Daegu 41566, South Korea | 57194577241; 57210961462; 57206624978; 56699607100; 56605735300; 55445825800; 55989441300; 7409879141; 56486163800; 57192413834; 57204150578 | yoonokhwa527@gmail.com;ptlinh@hpmu.edu.vn;nongddangol@gmail.com;s0870714@gmail.com;ehddy1313@naver.com;neoquack@gmail.com;whlee@cnu.ac.kr;cskim@cnu.ac.kr;srk75@knu.ac.kr;biohjp@gmail.com;visnu528@cnu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0.4 | 2025-06-25 | 16 | 11 | macrophages; microglia; neuropathic pain; neuroinflammation; arginase 2 | NITRIC-OXIDE; NEUROPATHIC PAIN; SPINAL-CORD; MICROGLIA; ACTIVATION; MECHANISMS | Arginase 2; Macrophages; Microglia; Neuroinflammation; Neuropathic pain | arginase; arginase 2; interleukin 10; interleukin 1beta; interleukin 4; nitric oxide synthase; reactive oxygen metabolite; unclassified drug; animal experiment; animal model; animal tissue; Arg2 gene; Article; astrocytosis; behavior; catwalk gait analysis test; controlled study; down regulation; enzyme deficiency; gene; gliosis; immunohistochemistry; immunoreactivity; knockout gene; macrophage; male; microglia; mouse; nerve injury; nervous system inflammation; nervous tissue; neuropathic pain; nonhuman; protein expression; real time polymerase chain reaction; spinal nerve; upregulation; Western blotting | English | 2020 | 2020-02 | 10.3390/jcm9020305 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Article uterine cervical change at term examined using ultrasound elastography: A longitudinal study | The aim of the study was to investigate if there are changes in elastographic parameters in the cervix at term around the time of delivery and if there are differences in the parameters between women with spontaneous labor and those without labor (labor induction). Nulliparous women at 36 weeks of gestation eligible for vaginal delivery were enrolled. Cervical elastography was performed and cervical length were measured using the E-Cervix™ system (WS80A Ultrasound System, Samsung Medison, Seoul, Korea) at each weekly antenatal visit until admission for spontaneous labor or labor induction. E-Cervix parameters of interest included elasticity contrast index (ECI), internal os strain mean level (IOS), external os strain mean level (EOS), IOS/EOS strain mean ratio, strain mean level, and hardness ratio. Regression analysis was performed using days from elastographic measurement at each visit to admission for delivery and the presence or absence of labor against cervical length, and each E-Cervix parameter fitted to a linear model for longitudinal data measured repeatedly. A total of 96 women were included in the analysis, (spontaneous labor, n = 39; labor induction, n = 57). Baseline characteristics were not different between the two groups except for cesarean delivery rate. Cervical length decreased with advancing gestation and was different between the two groups. Most elastographic parameters including ECI, IOS, EOS, strain mean, and hardness ratio were significantly different between the two groups. In addition, ECI, IOS, and strain mean values significantly increased with advancing gestation. Our longitudinal study using ultrasound elastography indicated that E-cervix parameters tended to change linearly at term near the time of admission for delivery and that there were differences in E-Cervix parameters according to the presence or absence of labor. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | Park, Hyun Soo; Kwon, Hayan; Kwon, Ja-Young; Jung, Yun Ji; Seol, Hyun-Joo; Seong, Won Joon; Kim, Hyun Mi; Hwang, Han-Sung; Sung, Ji-Hee; Oh, Soo-Young | Department of Obstetrics and Gynecology, Dongguk University Ilsan Hospital, Dongguk University, Goyang, 10326, South Korea; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Institute of Women’s Medical Life Science, Yonsei University College of Medicine, Yonsei University Health System, Seoul, 03722, South Korea; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Institute of Women’s Medical Life Science, Yonsei University College of Medicine, Yonsei University Health System, Seoul, 03722, South Korea; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Institute of Women’s Medical Life Science, Yonsei University College of Medicine, Yonsei University Health System, Seoul, 03722, South Korea; Department of Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, Seoul, 05278, South Korea; Department of Obstetrics and Gynecology, Kyungpook National University Hospital, Daegu, 41944, South Korea; Department of Obstetrics and Gynecology, Kyungpook National University Hospital, Daegu, 41944, South Korea; Department of Obstetrics and Gynecology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, 05030, South Korea; Samsung Medical Center, Department of Obstetrics and Gynecology, Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea; Samsung Medical Center, Department of Obstetrics and Gynecology, Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea | 57201459522; 36865684900; 8656241100; 56581000200; 15924081200; 26656946000; 57219838830; 17345595900; 56347330000; 55601514300 | hsparkmd@gmail.com; | Journal of Clinical Medicine | J CLIN MED | N/A | 2077-0383 | 10 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0.48 | 2025-06-25 | 7 | Elastography; Parturition; Term pregnancy; Ultrasonography; Uterine cervix | adult; article; cervical length; cesarean section; echography; elastography; female; hardness; human; human experiment; labor induction; longitudinal study; major clinical study; nullipara; pregnancy; South Korea; vaginal delivery | English | Final | 2020 | 10.3390/jcm10010075 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Clinical Impact of Atypical Chest Pain and Diabetes Mellitus in Patients with Acute Myocardial Infarction from Prospective KAMIR-NIH Registry | Atypical chest pain and diabetic autonomic neuropathy attract less clinical attention, leading to underdiagnosis and delayed treatment. To evaluate the long-term clinical impact of atypical chest pain and diabetes mellitus (DM), we categorized 11,159 patients with acute myocardial infarction (AMI) from the Korea AMI-National Institutes of Health between November 2011 and December 2015 into four groups (atypical DM, atypical non-DM, typical DM, and typical non-DM). The primary endpoint was defined as patient-oriented composite endpoint (POCE) at 2 years including all-cause death, any myocardial infarction (MI), and any revascularization. Patients with atypical chest pain showed higher 2-year mortality than those with typical chest pain in both DM (29.5% vs. 11.4%, p < 0.0001) and non-DM (20.4% vs. 6.3%, p < 0.0001) groups. The atypical DM group had the highest risks of POCE (hazard ratio (HR) 1.76, 95% confidence interval (CI) 1.48-2.10), all-cause death (HR 2.23, 95% CI 1.80-2.76) and any MI (HR 2.34, 95% CI 1.51-3.64) in the adjusted model. In conclusion, atypical chest pain was significantly associated with mortality in patients with AMI. Among four groups, the atypical DM group showed the worst clinical outcomes at 2 years. Application of rapid rule in/out AMI protocols would be beneficial to improve clinical outcomes. | Lee, Jun-Won; Moon, Jin Sil; Kang, Dae Ryong; Lee, Sang Jun; Son, Jung-Woo; Youn, Young Jin; Ahn, Sung Gyun; Ahn, Min-Soo; Kim, Jang-Young; Yoo, Byung-Su; Lee, Seung-Hwan; Kim, Ju Han; Jeong, Myung Ho; Park, Jong-Seon; Chae, Shung Chull; Hur, Seung Ho; Cho, Myeng-Chan; Rha, Seung Woon; Cha, Kwang Soo; Chae, Jei Keon; Choi, Dong-Ju; Seong, In Whan; Oh, Seok Kyu; Hwang, Jin Yong; Yoon, Junghan | Yonsei Univ, Wonju Coll Med, Div Cardiol, Dept Internal Med, Wonju 26426, South Korea; Yonsei Univ, Wonju Coll Med, Ctr Biomed Data Sci, Wonju 26426, South Korea; Chonnam Natl Univ Hosp, Dept Internal Med, Gwangju 61469, South Korea; Chonnam Natl Univ Hosp, Ctr Heart, Gwangju 61469, South Korea; Yeungnam Univ, Dept Internal Med, Div Cardiol, Coll Med,Med Ctr, Daegu 42415, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Internal Med, Sch Med, Daegu 41944, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Internal Med, Daegu 42601, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju 28644, South Korea; Korea Univ, Guro Hosp, Ctr Cardiovasc, Seoul 08308, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, Busan 49241, South Korea; Chunbuk Natl Univ, Dept Internal Med, Div Cardiol, Sch Med, Jeonju 54907, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam 13620, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Coll Med, Dept Internal Med, Daejeon 35015, South Korea; Wonkwang Univ, Dept Internal Med, Sch Med, Div Cardiol, Iksan 54538, South Korea; Gyungsang Natl Univ, Gyungsang Natl Univ Hosp, Dept Internal Med, Sch Med, Jinju 52727, South Korea | ; Lee, Sang-Jun/A-3892-2015; Han, Jae-Young/AAV-1100-2021; Kim, Nam Hoon/HNS-5794-2023; Jeong, Young-Hoon/F-3476-2015; Choi, Dong-Ju/J-5686-2012; Rha, Seung-Woon/AGE-5810-2022; Lee, Junseong/T-4139-2017; Lee, Seung Hwan/AAE-4710-2022; Ahn, Sung Gyun/AAG-5976-2020 | 37960999000; 57204644385; 57225957770; 57213176489; 57201929388; 23089707400; 14119543700; 23088120600; 57202767451; 7102851884; 56714956900; 57196169644; 55160374300; 15763054600; 7101962036; 34570274500; 7401727518; 8569030400; 7102837700; 26029709000; 35274349200; 35254371300; 24734336000; 55892914700; 35760728900 | ljwcardio@yonsei.ac.kr;mjs0512@yonsei.ac.kr;dr.kang@yonsei.ac.kr;sang3621@yonsei.ac.kr;sonjwoo@yonsei.ac.kr;younyj@yonsei.ac.kr;sgahn@yonsei.ac.kr;heartsaver@yonsei.ac.kr;kimjy@yonsei.ac.kr;yubs@yonsei.ac.kr;carshlee@yonsei.ac.kr;kim@zuhan.com;myungho@chollian.net;pjs@med.yu.ac.kr;scchae@knu.ac.kr;shur@dsmc.or.kr;mccho@cbnu.ac.kr;swrha617@yahoo.co.kr;chakws1@hanmail.net;jkchae@chonbuk.ac.kr;djchoi@snu.ac.kr;iwseong@cnu.ac.kr;oskcar@wku.ac.kr;jyhwang@gnu.ac.kr;jyoon@yonsei.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0.32 | 2025-06-25 | 6 | 9 | chest pain; diabetes; myocardial infarction | AUTONOMIC DYSFUNCTION; MORTALITY; RISK; DIAGNOSIS; SYMPTOMS; CARE | Chest pain; Diabetes; Myocardial infarction | acetylsalicylic acid; beta adrenergic receptor blocking agent; biological marker; calcium channel blocking agent; hydroxymethylglutaryl coenzyme A reductase inhibitor; P2Y12 inhibitor; protein inhibitor; purinergic P2Y12 receptor; renin angiotensin system inhibitor; unclassified drug; acute heart infarction; aged; all cause mortality; Article; body height; body mass; body weight; cardiovascular mortality; chronic kidney failure; clinical outcome; cohort analysis; controlled clinical trial; controlled study; diabetes mellitus; electrocardiography monitoring; female; follow up; heart infarction; human; incidence; Korea; major clinical study; male; multicenter study; observational study; outcome assessment; prospective study; revascularization; ST segment elevation myocardial infarction; thorax pain; types of study | English | 2020 | 2020-02 | 10.3390/jcm9020505 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Clinical Significance of Timing of Intubation in Critically Ill Patients with COVID-19: A Multi-Center Retrospective Study | The effect of intubation timing on the prognosis of critically ill patients with coronavirus 2019 (COVID-19) is not yet well understood. We investigated whether early intubation is associated with the survival of COVID-19 patients with acute respiratory distress syndrome (ARDS). This multicenter, retrospective, observational study was done on 47 adult COVID-19 patients with ARDS who were admitted to the intensive care unit (ICU) in Daegu, Korea between February 17 and April 23, 2020. Clinical characteristics and in-hospital mortality were compared between the early intubation and initially non-intubated groups, and between the early and late intubation groups, respectively. Of the 47 patients studied, 23 (48.9%) were intubated on the day of meeting ARDS criteria (early intubation), while 24 (51.1%) were not initially intubated. Eight patients were never intubated during the in-hospital course. Median follow-up duration was 46 days, and 21 patients (44.7%) died in the hospital. No significant difference in in-hospital mortality rate was noted between the early group and initially non-intubated groups (56.5% vs. 33.3%,p= 0.110). Furthermore, the risk of in-hospital death in the early intubation group was not significantly different compared to the initially non-intubated group on multivariate adjusted analysis (p= 0.385). Results were similar between early and late intubation in the subgroup analysis of 39 patients treated with mechanical ventilation. In conclusion, in this study of critically ill COVID-19 patients with ARDS, early intubation was not associated with improved survival. This result may help in the efficient allocation of limited medical resources, such as ventilators. | Lee, Yong Hoon; Choi, Keum-Ju; Choi, Sun Ha; Lee, Shin Yup; Kim, Kyung Chan; Kim, Eun Jin; Lee, Jaehee | Kyungpook Natl Univ, Sch Med, Div Pulm & Crit Care Med, Dept Internal Med, Daegu 41944, South Korea; Daegu Vet Hosp, Dept Internal Med, Daegu 42835, South Korea; Daegu Catholic Univ, Sch Med, Dept Internal Med, Daegu 42472, South Korea | Kim, Eun Jin/L-6480-2018; Lee, Jaehee/S-1697-2018; Choi, Sun Ha/HPD-7234-2023; Kim, Eun/AAS-6706-2020; Lee, Jun Young/CAI-2335-2022 | 57199022948; 58945401100; 57199723585; 49863712700; 55667010800; 55927957400; 13805476000 | yhlee2020@knu.ac.kr;tvbogo@naver.com;sunha20@knu.ac.kr;shinyup@knu.ac.kr;solar903@chol.com;ejkim77@cu.ac.kr;jaelee@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 2.79 | 2025-06-25 | 35 | 41 | COVID-19; acute respiratory distress syndrome; intubation; respiratory failure; mortality; intensive care units | HIGH-FLOW OXYGEN; THERAPY | Acute respiratory distress syndrome; COVID-19; Intensive care units; Intubation; Mortality; Respiratory failure | creatine kinase MB; troponin I; acute respiratory failure; adult; adult respiratory distress syndrome; aged; APACHE; arterial pH; Article; artificial ventilation; clinical article; clinical feature; clinical outcome; coronavirus disease 2019; critically ill patient; extracorporeal oxygenation; female; follow up; high flow nasal cannula therapy; hospital acquired pneumonia; hospital mortality; hospitalization; human; hypoxemia; intensive care unit; male; middle aged; multicenter study; observational study; positive pressure ventilation; prognosis; real time reverse transcription polymerase chain reaction; respiratory tract intubation; retrospective study; Sequential Organ Failure Assessment Score; thorax radiography; time to treatment; tracheostomy; ventilator associated pneumonia | English | 2020 | 2020-09 | 10.3390/jcm9092847 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Cohen Syndrome Patient iPSC-Derived Neurospheres and Forebrain-Like Glutamatergic Neurons Reveal Reduced Proliferation of Neural Progenitor Cells and Altered Expression of Synapse Genes | Cohen syndrome (CS), a rare autosomal recessive disorder, has been associated with genetic mutations in theVPS13Bgene, which regulates vesicle-mediated protein sorting and transport. However, the cellular mechanism underlying CS pathogenesis in patient-derived human neurons remains unknown. We identified a novel compound heterozygous mutation, due to homozygous variation of biparental origin and heterozygous variation inherited from the father, in theVPS13Bgene in a 20-month-old female patient. To understand the cellular pathogenic mechanisms, we generated induced pluripotent stem cells (iPSCs) from the fibroblasts of the CS patient. The iPSCs were differentiated into forebrain-like functional glutamatergic neurons or neurospheres. Functional annotation from transcriptomic analysis using CS iPSC-derived neurons revealed that synapse-related functions were enriched among the upregulated and downregulated genes in the CS neurons, whereas processes associated with neurodevelopment were enriched in the downregulated genes. The developing CS neurospheres were small in size compared to control neurospheres, likely due to the reduced proliferation of SOX2-positive neural stem cells. Moreover, the number of SV2B-positive puncta and spine-like structures was significantly reduced in the CS neurons, suggesting synaptic dysfunction. Taking these findings together, for the first time, we report a potential cellular pathogenic mechanism which reveals the alteration of neurodevelopment-related genes and the dysregulation of synaptic function in the human induced neurons differentiated from iPSCs and neurospheres of a CS patient. | Lee, You-Kyung; Hwang, Su-Kyeong; Lee, Soo-Kyung; Yang, Jung-eun; Kwak, Ji-Hye; Seo, Hyunhyo; Ahn, Hyunjun; Lee, Yong-Seok; Kim, Janghwan; Lim, Chae-Seok; Kaang, Bong-Kiun; Lee, Jae-Hyung; Lee, Jin-A; Lee, Kyungmin | Hannam Univ, Dept Biotechnol & Biol Sci, Daejeon 34430, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu 41944, South Korea; Seoul Natl Univ, Coll Nat Sci, Dept Biol Sci, Seoul 08826, South Korea; Kyungpook Natl Univ, Sch Med, Brain Sci & Engn Inst, Dept Anat, Daegu 41944, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Stem Cell Convergence Res Ctr, Daejeon 34141, South Korea; Univ Sci & Technol, KRIBB Sch Biosci, Dept Funct Genom, Daejeon 34113, South Korea; Seoul Natl Univ, Neurosci Res Inst, Dept Physiol, Coll Med, Seoul 03080, South Korea; Wonkwang Univ, Dept Pharmacol, Sch Med, Iksan 54538, South Korea; Kyung Hee Univ, Sch Dent, Dept Life & Nanopharmaceut Sci, Dept Oral Microbiol, Seoul 02447, South Korea | ; Kim, Yong-Jin/GYQ-9206-2022; SEO, Hyunhyo/AAR-6343-2021; Lee, Yong/J-5587-2012; Lee, Jae-Hyung/E-6827-2011; Lee, Kyungmin/ABC-5624-2020 | 56651292200; 37761570400; 57219747105; 56899164700; 56689173300; 56611228800; 56849829900; 57049728800; 7601386662; 7403654010; 7003889686; 55690041500; 35337365000; 57211016316 | alskgogo77@gmail.com;neurobaby79@gmail.com;cw02374@gmail.com;yje1001@gmail.com;jhkwak@knu.ac.kr;hseo@knu.ac.kr;handisilver@gmail.com;yongseok7@snu.ac.kr;janghwan546@gmail.com;cslimwk1@wku.ac.kr;kaang@snu.ac.kr;jaehlee@khu.ac.kr;leeja@hnu.kr;irislkm@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 6 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0.72 | 2025-06-25 | 12 | 12 | Cohen syndrome; VPS13B; induced pluripotent stem cells (iPSCs); neurosphere; transcriptomic analysis | SYNDROME-ASSOCIATED PROTEIN; HUMAN BRAIN-DEVELOPMENT; ORGANOIDS; STEM; INDUCTION; VARIANTS; COMPLEX; CAMK2A; REGION; MODEL | Cohen syndrome; Induced pluripotent stem cells (iPSCs); Neurosphere; Transcriptomic analysis; VPS13B | alkaline phosphatase; transcription factor Sox2; Article; autosomal recessive disorder; cell culture; cell differentiation; cell proliferation; chemoluminescence; child; clinical article; cohen syndrome; confocal microscopy; electrophysiology; electroporation; female; gene; gene expression; gene mutation; genetic disorder; glutamatergic synapse; human; human cell; immunocytochemistry; immunohistochemistry; induced pluripotent stem cell; karyotype; microarray analysis; nerve cell; nervous system development; preschool child; protein targeting; reverse transcription; reverse transcription real time polymerase chain reaction; RNA sequence; RNA sequencing; Sanger sequencing; synapse; VPS13B gene; Western blotting; whole exome sequencing | English | 2020 | 2020-06 | 10.3390/jcm9061886 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Common Extensor Complex Is a Predictor to Determine the Stability in Simple Posterolateral Elbow Dislocation: Analysis of MR Images of Stable vs. Unstable Dislocation | Simple posterolateral elbow dislocations (SPLED) may be treated nonoperatively using closed reduction, followed by controlled mobilization. However, the extent of soft tissue injuries might affect the choice of treatment, rehabilitation approach, and prognosis. The purpose of this study is to compare the characteristics of soft tissue injuries between patients with unstable and stable SPLED using MRI findings. Thirty MRIs of elbows with SPLED (unstable group (n = 15); stable group (n = 15)) were randomly reviewed by two experienced musculoskeletal radiologists. Soft tissue injuries were characterized as an intact, partial tear or complete tear for the: medial collateral ligament (MCL) complex, common flexor complex, lateral collateral ligament (LCL) complex, common extensor complex, anterior capsule, and posterior capsule. Moderate to substantial interobserver reliability and substantial to perfect intraobserver reliability were observed for medial and lateral complexes in SPLED. The proportion of soft-tissue injuries of the common extensor complex were significantly different between the unstable (four partial tears and 11 complete tears) and stable groups (11 partial tears and four complete tears). In conclusion, based on MRI findings, the degree of common extensor complex injuries may be a predictor of stability and help inform treatment decisions for SPLED. | Cho, Chul-Hyun; Kim, Beom-Soo; Yi, Jaehyuck; Lee, Hoseok; Kim, Du-Han | Keimyung Univ, Sch Med, Dept Orthoped Surg, Daegu 42601, South Korea; Keimyung Univ, Sch Med, Dept Radiol, Daegu 42601, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu 41566, South Korea | , Do Hyun Kim/J-4567-2017 | 35785599900; 57161242900; 35338638100; 57200653487; 57192702203 | oscho5362@dsmc.or.kr;BSKim@dsmc.or.kr;yijh72@gmail.com;cathrad@hananet.net;osmdkdh@gmail.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 10 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 0.16 | 2025-06-25 | 1 | 3 | elbow; dislocation; ligament; tendon; tear; MRI | ULNAR COLLATERAL LIGAMENT; ROTATORY INSTABILITY; ARTHROGRAPHY; RELIABILITY; SEQUENCES; INJURIES; OUTCOMES; JOINT | Dislocation; Elbow; Ligament; MRI; Tear; Tendon | adult; aged; Article; clinical article; cohort analysis; elbow; elbow dislocation; extensor muscle; female; human; interrater reliability; intrarater reliability; joint capsule; joint stability; lateral collateral ligament; male; medial collateral ligament; musculoskeletal radiologist; nuclear magnetic resonance imaging; predictor variable; retrospective study; soft tissue injury | English | 2020 | 2020-10 | 10.3390/jcm9103094 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Fatal Outcomes of COVID-19 in Patients with Severe Acute Kidney Injury | The outcome of coronavirus disease 2019 (COVID-19) is associated with organ damage; however, the information about the relationship between acute kidney injury (AKI) and COVID-19 is still rare. We evaluated the clinical features and prognosis of COVID-19 patients with AKI according to the AKI severity. Medical data of hospitalized COVID-19 patients in two university-based hospitals during an outbreak in Daegu, South Korea, were retrospectively analyzed. AKI and its severity were defined according to the Acute Kidney Injury Network. Of the 164 hospitalized patients with COVID-19, 30 patients (18.3%) had AKI; 14, 4, and 12 patients had stage 1, 2, and 3, respectively. The median age was significantly higher in AKI patients than in non-AKI patients (75.5 vs. 67.0 years,p= 0.005). There were 17 deaths (56.7%) among AKI patients; 4 (28.6%), 1 (25.0%), and 12 (100.0%), respectively. In-hospital mortality was higher in AKI patients than in non-AKI patients (56.7% vs. 20.8%,p< 0.001). After adjusting for potential confounding factors, stage 3 AKI was associated with higher mortality than either non-AKI or stage 1 AKI (hazard ratio (HR) = 3.62 (95% confidence interval (CI) = 1.75-7.48),p= 0.001; HR = 15.65 (95% CI = 2.43-100.64),p= 0.004). Among the AKI patients, acute respiratory distress syndrome and low serum albumin on admission were considered independent risk factors for stage 3 AKI (bothp <0.05). Five patients with stage 3 AKI underwent dialysis and eventually died. In conclusion, COVID-19 patients with severe AKI had fatal outcomes. | Lim, Jeong-Hoon; Park, Sun-Hee; Jeon, Yena; Cho, Jang-Hee; Jung, Hee-Yeon; Choi, Ji-Young; Kim, Chan-Duck; Lee, Yong-Hoon; Seo, Hyewon; Lee, Jaehee; Kwon, Ki Tae; Kim, Shin-Woo; Chang, Hyun-Ha; Kim, Yong-Lim | Kyungpook Natl Univ, Sch Med, Div Nephrol, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea; Kyungpook Natl Univ, Div Pulmonol & Crit Care Med, Dept Internal Med, Sch Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Div Infect Dis, Dept Internal Med, Sch Med, Daegu 41944, South Korea | Lim, Jeong-Hoon/ABE-6003-2020; Kim, Yong-Lim/AGK-3172-2022; Lee, Jaehee/S-1697-2018; Park, Sun-Hee/LMN-0033-2024; Lee, Jun Young/CAI-2335-2022; Kim, Hanjin/KYP-2633-2024; Cho, Jang-hee/ABD-3534-2020 | 55360244300; 7501831741; 57209909350; 7403536291; 57196396467; 7501393222; 8558530700; 57199022948; 55612130200; 13805476000; 9733850500; 8710731500; 7407521688; 55633533600 | jh-lim@knu.ac.kr;sh-park@knu.ac.kr;yeahnah@naver.com;jh-cho@knu.ac.kr;hy-jung@knu.ac.kr;jyss1002@hanmail.net;drcdkim@knu.ac.kr;id0121@naver.com;dallyu17@hanmail.net;jaelee@knu.ac.kr;idktkwon@gmail.com;ksw2kms@knu.ac.kr;changhha@knu.ac.kr;ylkim@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 9 | 6 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 4.242 | 23.1 | 4.94 | 2025-06-25 | 57 | 65 | acute kidney injury; AKI severity; COVID-19; mortality; renal replacement therapy | SARS | Acute kidney injury; AKI severity; COVID-19; Mortality; Renal replacement therapy | alanine aminotransferase; albumin; antibiotic agent; aspartate aminotransferase; bilirubin; C reactive protein; cobicistat plus darunavir; creatinine; D dimer; ferritin; glucocorticoid; hemoglobin; hydroxychloroquine; immunoglobulin; inotropic agent; lopinavir plus ritonavir; procalcitonin; acute kidney failure; Acute Kidney Injury Network classification; adult; adult respiratory distress syndrome; aged; Article; artificial ventilation; asymptomatic infection; body mass; clinical feature; continuous renal replacement therapy; coronavirus disease 2019; dialysis; disease severity; disseminated intravascular clotting; estimated glomerular filtration rate; fatality; female; gene dosage; heart arrhythmia; hospital mortality; human; hyperkalemia; kidney function test; length of stay; leukocyte count; lymphocyte count; major clinical study; male; monocyte count; oxygen therapy; prognosis; prothrombin time; real time reverse transcription polymerase chain reaction; retrospective study; risk factor; septic shock; thorax radiography; throat culture; urea nitrogen blood level | English | 2020 | 2020-06 | 10.3390/jcm9061718 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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