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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Evaluation of Growth and Photosynthetic Rate of Cucumber Seedlings Affected by Far-Red Light Using a Semi-Open Chamber and Imaging System | Far-red light was excluded in photosynthetic photon flux; however, recent studies have shown that it increases photosynthetic capacity. In addition, there were few studies on the whole canopy photosynthetic rate and continuous changes of morphology on cucumber seedlings affected by far-red light. This study evaluated the effect of conventional white LEDs adding far-red light on cucumber seedlings using a semi-open chamber system for the measurement of the whole canopy gas exchange rate, and the Raspberry Pi-based imaging system for the analysis of a continuous image. In the image, through the imaging system, it was confirmed that far-red light promoted the germination rate of cucumber seedlings and enhanced early growth. However, the dry weight of the shoot and root did not increase. The measured net apparent CO2 assimilation rate was improved by an increasing leaf area during the cultivation period. The conventional white LED light source with added far-red light increased the photosynthetic rate of cucumber seedlings' whole canopy. However, at the early seedling stage, plant height and leaf area of the whole canopy was increased by far-red light, and it was revealed that the image data saturated faster. It was considered that the photosynthetic efficiency decreased due to a shading effect of the limited planting density of the cell tray. The results found that using appropriate far-red light, considering planting density, could increase the photosynthetic rate of the whole canopy of crops, thereby promoting crop growth, but it was judged that the use of far-red light in the early growth stage of cucumber seedlings should be considered carefully. | Moon, Yu Hyun; Yang, Myongkyoon; Woo, Ui Jeong; Sim, Ha Seon; Lee, Tae Yeon; Shin, Ha Rang; Jo, Jung Su; Kim, Sung Kyeom | Kyungpook Natl Univ, Dept Hort Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Smart Agr Innovat Ctr, Daegu 41566, South Korea | ; Kim, Sung Kyeom/AAD-9230-2019 | 57226272477; 57194176323; 57226269481; 57220890640; 58069843600; 58069726600; 57197337268; 50262290200 | skkim76@knu.ac.kr; | HORTICULTURAE | HORTICULTURAE | 2311-7524 | 9 | 1 | SCIE | HORTICULTURE | 2023 | 3.1 | 17.1 | 1.15 | 2025-06-25 | 7 | 7 | far-red light; whole canopy photosynthesis; cucumber seedling; Raspberry Pi | PHOTOSYSTEM-I; PHYTOCHROME; LEAVES; PLANT; PHOTOMORPHOGENESIS; ARABIDOPSIS; MORPHOLOGY; TRANSPORT; QUALITY; SPA1 | cucumber seedling; far-red light; Raspberry Pi; whole canopy photosynthesis | English | 2023 | 2023-01 | 10.3390/horticulturae9010098 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Exploration of Ternary Logic Using T-CMOS for Circuit-Level Design | The predicted end of scaling and the exponential increase of user data in the era of the connected world are asking whether the current binary systems in CMOS can successfully provide solutions to the expected challenges. Regarding these challenges, ternary systems are showing a high potential to provide solutions to these known issues. In detail, the tunnelling-based MOSFET (T-CMOS) is reported as promising compared to any other ternary devices studied. However, despite the potential, studies lack how a complete system can be designed in actual T-CMOS-based circuitry. Therefore, in this paper, we provide a holistic study of how T-CMOS-based circuits can be designed. In detail, 1) we provide a pathway to designing a balanced ternary full adder and provide the fundamental of how combinational ternary logic can be designed in T-CMOS. 2) We present various sequential ternary logic based on T-CMOS. 3) We present various circuit techniques that could enhance the performance of combinational and sequential ternary logic. Based on our study, we provide the first balanced ternary adder that the transistor count is only 42 and enhance the operating frequency of the T-CMOS-based ternary system by 5.6 × to 58.5 × . © 2004-2012 IEEE. | Ko, Jonghyun; Kim, Jongbeom; Jeong, Taegam; Jeong, Jaehoon; Song, Taigon | Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Korea Advanced Institute of Science and Technology (KAIST), School of Electrical Engineering, Daejeon, 34141, South Korea; Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea | 59809554200; 57782068500; 57226890394; 57226881576; 36005021000 | tsong@knu.ac.kr; | IEEE Transactions on Circuits and Systems I: Regular Papers | IEEE T CIRCUITS-I | 1549-8328 | 1558-0806 | 70 | 9 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2023 | 5.2 | 17.1 | 1.22 | 2025-06-25 | 10 | T-CMOS; ternary full adder; ternary logic | Adders; CMOS integrated circuits; Computer circuits; Integrated circuit design; Logic circuits; Many valued logics; MOSFET devices; Timing circuits; 'current; Circuit level design; CNTFET; Exponential increase; Full adders; Scalings; T-CMOS; Ternary full adder; Ternary logic; User data; Threshold voltage | English | Final | 2023 | 10.1109/tcsi.2023.3287274 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells | Among the various cell types that constitute the liver, Kupffer cells (KCs) are responsible for the elimination of gut-derived foreign products. Protein lysine acetylation (Kac) and lactylation (Kla) are dynamic and reversible post-translational modifications, and various global acylome studies have been conducted for liver and liver-derived cells. However, no such studies have been conducted on KCs. In this study, we identified 2198 Kac sites in 925 acetylated proteins and 289 Kla sites in 181 lactylated proteins in immortalized mouse KCs using global acylome technology. The subcellular distributions of proteins with Kac and Kla site modifications differed. Similarly, the specific sequence motifs surrounding acetylated or lactylated lysine residues also showed differences. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to better understand the differentially expressed proteins in the studies by Kac and Kla. In the newly identified Kla, we found K82 lactylation in the high-mobility group box-1 protein in the neutrophil extracellular trap formation category using KEGG enrichment analyses. Here, we report the first proteomic survey of Kac and Kla in KCs. | Sung, Eunji; Sim, Hyunchae; Cho, Young-Chang; Lee, Wonhwa; Bae, Jong-Sup; Tan, Minjia; Lee, Sangkyu | Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea; Chonnam Natl Univ, Coll Pharm, Gwangju 61186, South Korea; Sungkyunkwan Univ, Dept Chem, Suwon 16419, South Korea; Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China | ; choi, sun ryoung/AGZ-1893-2022; Lee, Wonhwa/GLQ-6506-2022; Tan, Minjia/C-4491-2014 | 56988948200; 57219098739; 55472205600; 50161632800; 16021543200; 36027735400; 57209046767 | sangkyu@skku.edu; | JOURNAL OF PROTEOME RESEARCH | J PROTEOME RES | 1535-3893 | 1535-3907 | 22 | 12 | SCIE | BIOCHEMICAL RESEARCH METHODS | 2023 | 3.8 | 17.1 | 0.54 | 2025-06-25 | 8 | 6 | global proteomics; Kupffer cells; lysine acetylation; lysine lactylation; proteinmodification | GROUP BOX 1; METABOLIC-REGULATION; PROTEOMIC ANALYSIS; PROTEIN; ACETYLOME; SIRT3 | global proteomics; Kupffer cells; lysine acetylation; lysine lactylation; protein modification | Acetylation; Animals; Kupffer Cells; Lysine; Mice; Protein Processing, Post-Translational; Proteome; Proteomics; high mobility group B1 protein; lysine; lysine; proteome; animal cell; Article; cell culture; cellular distribution; controlled study; differential gene expression; gene ontology; KEGG; Kupffer cell; liquid chromatography-mass spectrometry; mouse; NETosis; nonhuman; protein acetylation; protein fingerprinting; protein lactylation; protein modification; Western blotting; acetylation; animal; chemistry; metabolism; protein processing; proteomics | English | 2023 | 2023-10-28 | 10.1021/acs.jproteome.3c00156 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Impact of Irrigation with Contaminated Water on Heavy Metal Bioaccumulation in Water Chestnut (Trapa natans L.) | This study investigated the monitoring of six heavy metals (Cd, Cr, Cu, Fe, Mn, and Zn) in pond water, sludge, and cultivated water chestnut (Trapa natans L.) crops in Saharanpur district of Uttar Pradesh, India. For this purpose, samples of pond water, sludge, and T. natans plant (nut, shoot, and root) were collected in November of 2021 and 2022 from three zones (Zone 1: agricultural area irrigated with borewell water, Zone 2: urban area irrigated with municipal wastewater, and Zone 3: rural area irrigated with mixed type of wastewater) and subsequently analyzed for heavy metal concentration using atomic absorption spectroscopy. The results showed that the physicochemical and heavy metal characteristics of pond water and sludge were significantly (p < 0.05) higher in Zone 2 and 3 than to those in Zone 1. The concentration of heavy metals in T. natans root was comparatively high followed by shoot and nut parts. The bioaccumulation factor (BAF) was maximum while using pond water as a reference medium compared to pond sludge. Overall, the increasing order of heavy metals in T. natans was observed as Cd < Cr < Cu < Zn < Mn < Fe. In the edible part (nut) of T. natans, the average contents of Cd (0.005 +/- 0.002 mg/kg), Cr (0.134 +/- 0.009 mg/kg), Cu (1.043 +/- 0.104 mg/kg), Fe (9.589 +/- 0.957 mg/kg), Mn (4.326 +/- 0.753 mg/kg), and Zn (1.540 +/- 0.537 mg/kg) were comparatively less than shoot and root parts. Overall, the results revealed that T. natans irrigated with contaminated irrigation supplies at Zone 2 and 3 showed the highest BAF of heavy metals than Zone 1. Because the heavy metal concentrations in edible parts of T. natans did not exceed the threshold limits, the contaminated water sources in the Saharanpur region of India should be used in a safe and controlled manner. | Taher, Mostafa A.; Zouidi, Ferjeni; Kumar, Pankaj; Abou Fayssal, Sami; Adelodun, Bashir; Goala, Madhumita; Kumar, Vinod; Andabaka, Zeljko; Siric, Ivan; Eid, Ebrahem M. | King Khalid Univ, Fac Sci & Arts, Biol Dept, Mohail Assir 61321, Saudi Arabia; Aswan Univ, Fac Sci, Bot Dept, Aswan 81528, Egypt; Gurukula Kangri, Dept Zool & Environm Sci, Agroecol & Pollut Res Lab, Haridwar 249404, Uttaranchal, India; Univ Forestry, Fac Agron, Dept Agron, 10 Kliment Ohridski Blvd, Sofia 1797, Bulgaria; Lebanese Univ, Fac Agr, Dept Plant Prod, Beirut, Lebanon; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin 240003, Nigeria; Kyungpook Natl Univ, Dept Agr Civil Engn, Daegu 41566, South Korea; Affiliated Assam Univ, Nehru Coll, Silchar 788098, Assam, India; Univ Zagreb, Fac Agr, Svetosimunska 25, Zagreb 10000, Croatia; King Khalid Univ, Coll Sci, Biol Dept, Abha 61321, Saudi Arabia; Kafrelsheikh Univ, Fac Sci, Bot Dept, Kafr Al Sheikh 33516, Egypt | ; Abou Fayssal, Sami/ABF-6226-2020; Kumar, P.Vinod/HKP-1552-2023; Eid, Ebrahem/O-2723-2013; Kumar, Pankaj/AAF-2231-2019; Zouidi, Ferjeni/HPG-9944-2023; Taher, Mostafa/JNE-2285-2023; Kumar, Dr. Vinod/K-9971-2016; Adelodun, Bashir/O-2941-2018 | 57192983622; 55878304600; 57281192700; 57218598581; 57193774482; 57221943148; 57200152850; 55934838700; 55233815400; 35794350700 | isiric@agr.hr;ebrahem.eid@sci.kfs.edu.eg; | HORTICULTURAE | HORTICULTURAE | 2311-7524 | 9 | 2 | SCIE | HORTICULTURE | 2023 | 3.1 | 17.1 | 2.3 | 2025-06-25 | 11 | 12 | fruit contamination; health risk; irrigation water; pollution; toxic elements; wastewater reuse | WASTE-WATER; RISK-ASSESSMENT; SOIL; ACCUMULATION; VARIETIES; SEDIMENTS; NITROGEN; INDUSTRY; REMOVAL; PONDS | fruit contamination; health risk; irrigation water; pollution; toxic elements; wastewater reuse | English | 2023 | 2023-02 | 10.3390/horticulturae9020190 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Integrative Profiling of Lysine Acylome in Sepsis-Induced Liver Injury | Sepsis is one of the life-threatening diseases worldwide.Despitethe continuous progress in medicine, the specific mechanism of sepsisremains unclear. A key strategy of pathogens is to use post-translationalmodification to modulate host factors critical for infection. We employedglobal immunoprecipitation technology for lysine acetylation (Kac),succinylation (Ksu), and malonylation (Kmal) for the first globallysine acylation (Kacy) analysis in a cecum ligation and puncture(CLP) model in mouse. This was performed to reveal the pathogenicmechanism of integrative Kacy and the changes in modification sites.In total, 2230 sites of 1,235 Kac proteins, 1,887 sites of 433 Ksuproteins, and 499 sites of 276 Kmal proteins were quantified and normalizedby their protein levels. We focused on 379 sites in 219 upregulatedproteins as the integrative Kacy sites of Kac, Ksu, and Kmal on thebasis of sirtuins decreased in the CLP group. KEGG pathway analysisof integrative Kacy in 219 upregulated proteins revealed three centralmetabolic pathways: glycolysis/gluconeogenesis, pyruvate metabolism,and tricarboxylic acid cycle. These findings reveal the key pathogenicmechanism of integrative PTM alteration in terms of the decreasedsirtuins level and provide an important foundation for an in-depthstudy of the biological function of Kacy in sepsis. | Na, Ann-Yae; Choi, So Young; Paudel, Sanjita; Bae, Jong-Sup; Tan, Minjia; Lee, Sangkyu | Sungkyunkwan Univ, Global Drug Dev Res Inst, Suwon 16419, South Korea; Kyungpook Natl Univ, Mass Spectrometry Convergence Res Ctr, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea | Bae, Jong-Sup/AAU-9724-2020 | 57201530058; 57202918688; 57203320448; 16021543200; 36027735400; 57209046767 | sangkyu@skku.edu; | JOURNAL OF PROTEOME RESEARCH | J PROTEOME RES | 1535-3893 | 1535-3907 | 22 | 9 | SCIE | BIOCHEMICAL RESEARCH METHODS | 2023 | 3.8 | 17.1 | 0.11 | 2025-06-25 | 1 | 1 | cecum ligation and puncture model; sepsis; lysine acylation; liver dysfunction; protein modification | METABOLISM; SUCCINYLATION; MALONYLATION; SIRT5 | cecum ligation and puncture model; liver dysfunction; lysine acylation; protein modification; sepsis | Acetylation; Animals; Chemical and Drug Induced Liver Injury, Chronic; Lysine; Mice; Protein Processing, Post-Translational; Sepsis; Sirtuins; aromatase; beta actin; glutathione transferase; high mobility group B1 protein; host factor; immunoglobulin enhancer binding protein; interleukin 6; liver protein; lysine; protein; proteome; pyruvic acid; sirtuin; sirtuin 1; sirtuin 2; sirtuin 3; sirtuin 4; sirtuin 5; sirtuin 6; sirtuin 7; tumor necrosis factor; lysine; sirtuin; acetylation; acylation; animal experiment; animal model; animal tissue; Article; carbohydrate metabolism; cecum; chemical carcinogenesis; chemical reaction; citric acid cycle; controlled study; cytosol; false discovery rate; fatty acid metabolism; fractionation; gluconeogenesis; glycolysis; immunoblotting; immunoprecipitation; inner membrane; intracellular membrane; KEGG; ligation; liquid chromatography-mass spectrometry; lung injury; male; malonylation; metabolism; mouse; nonhuman; oxidation; protein analysis; protein expression; protein modification; real time reverse transcription polymerase chain reaction; sepsis; succinylation; upregulation; Western blotting; animal; chemical and drug induced liver injury; complication; genetics; protein processing | English | 2023 | 2023-07-31 | 10.1021/acs.jproteome.3c00130 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Mechanistic study of ultrasound-assisted chromatography using plastic and stainless steel columns | Based on the previous ultrasound-assisted chromatography (UAC) studies on plastic and stainless steel (SS) columns, this study explores the UAC mechanism by comparatively analyzing ultrasound effects on plastic and SS columns with C18 stationary phase when separating a mixture of polycyclic aromatic hydrocarbons (PAHs) under various ultrasound intensities. The results showed a substantial difference in H values between the PEEK and SS columns under the influence of ultrasound agitation. Specifically, for the pyrene peak, as the ultrasonic intensity increased from 0% to 100% of 900 W, the H values of the SS column slightly rose from 8.82 mu m to 9.86 mu m. Conversely, the corresponding values for the PEEK column exhibited a significant 12-fold increase from 11.5 mu m to 134 mu m. The findings demonstrated poor penetration of ultrasound energy through the SS column, and the temperature rise of the medium induced by the ultrasound was the primary contributing factor to PAH separation. However, ultrasound easily penetrated through the plastic column, resulting in acoustic cavitation within the C18 polyether ether ketone (PEEK) column. Cavitation induced heat generation and contributed to a decrease in retention time and the magnitude of peak broadening or distortion, depending on the specific ultrasonic energy. Based on the estimated change in inlet temperature of the PEEK column due to an acoustic effect, the comparison with temperature effects under non-sonic conditions consistently demonstrated a stronger acoustic effect in reducing the retention time, by 2-9%, depending on specific peaks and pairs. We revisited the previously described separation mechanism of ultrasound-assisted ion chromatography and conjoined with our findings to infer and establish a thorough explanation for the previously unexplained separation mechanism of chiral separation and size exclusion chromatography by UAC using SS columns. | Van Kien, Nguyen; Jeong, Young Han; Seog, David Jin Han; Ryoo, Jae Jeong | Kyungpook Natl Univ, Dept Chem Educ, Daegu 702701, South Korea | 55735049000; 36763733200; 58174646400; 7004847725 | jjryoo@knu.ac.kr; | JOURNAL OF CHROMATOGRAPHY A | J CHROMATOGR A | 0021-9673 | 1873-3778 | 1710 | SCIE | BIOCHEMICAL RESEARCH METHODS;CHEMISTRY, ANALYTICAL | 2023 | 3.8 | 17.1 | 0.38 | 2025-06-25 | 3 | 3 | Ultrasound-assisted chromatography; Mechanism; PEEK; Stainless steel; Cavitation | PERFORMANCE LIQUID-CHROMATOGRAPHY; REVERSED-PHASE CHROMATOGRAPHY; MOBILE-PHASE; SEPARATION EFFICIENCY; TEMPERATURE; SELECTIVITY; RETENTION; BEHAVIOR; ELUTION; TIME | Cavitation; Mechanism; PEEK; Stainless steel; Ultrasound-assisted chromatography | Benzophenones; Chromatography, High Pressure Liquid; Ketones; Polyethylene Glycols; Polymers; Stainless Steel; Cavitation; Chirality; Ethers; Ketones; Polycyclic aromatic hydrocarbons; Stainless steel; Ultrasonics; plastic; polycyclic aromatic hydrocarbon; polyetheretherketone; stainless steel; benzophenone derivative; ketone; macrogol; polymer; Acoustic effects; Mechanistic studies; Retention time; Separation mechanism; Stationary phase; Steel column; Ultrasonic intensity; Ultrasound agitation; Ultrasound intensity; Ultrasound-assisted chromatography; Article; chiral chromatography; chromatography; mechanics; size exclusion chromatography; temperature; ultrasound; ultrasound assisted chromatography; high performance liquid chromatography; procedures; Size exclusion chromatography | English | 2023 | 2023-11-08 | 10.1016/j.chroma.2023.464402 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Sustainable Use of CO2 and Wastewater from Mushroom Farm for Chlorella vulgaris Cultivation: Experimental and Kinetic Studies on Algal Growth and Pollutant Removal | The potential use of carbon dioxide (CO2) and wastewater released from a mushroom farm for the cultivation of Chlorella vulgaris microalga was investigated in this study. For this purpose, a microcontroller-based aided CO2 capture and mixing prototype was constructed for the cultivation of C. vulgaris under varying concentrations of mushroom farm wastewater (0 as control, 50 and 100%). The results showed that the constructed prototype was helpful to maintain desirable CO2 levels (6000 ppm) in the mushroom cultivation chamber with constant CO2 supply to algal culture, i.e., 0.6% at an airflow rate of 50 mL/min. After 16 days of algal cultivation, it was observed that the maximum significant (p 0.9938), model efficiency (ME > 0.98) and root mean square error (RMSE < 0.03). The post-harvest characterization of algal biomass revealed that the proximate, biochemical, ultimate elements (carbon, oxygen and nitrogen) and structural properties were significantly higher in 50% treatment than those in 100% and control treatments. Therefore, the findings of this study are novel and provide significant insight into the synergistic use of CO2 and wastewater produced by mushroom farms for algal cultivation and biological wastewater treatment. | Siric, Ivan; Abou Fayssal, Sami; Adelodun, Bashir; Mioc, Boro; Andabaka, Zeljko; Bachheti, Archana; Goala, Madhumita; Kumar, Pankaj; AL-Huqail, Arwa A. A.; Taher, Mostafa A. A.; Eid, Ebrahem M. M. | Univ Zagreb, Fac Agr, Svetosimunska 25, Zagreb 10000, Croatia; Univ Forestry, Fac Agron, Dept Agron, 10 Kliment Ohridski Blvd, Sofia 1797, Bulgaria; Lebanese Univ, Fac Agr, Dept Plant Prod, Beirut, Lebanon; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin 240003, Nigeria; Kyungpook Natl Univ, Dept Agr Civil Engn, Daegu 41566, South Korea; Graph Era Deemed Univ, Dept Environm Sci, Dehra Dun 248002, India; Gurukula Kangri Deemed Univ, Dept Zool & Environm Sci, Agroecol & Pollut Res Lab, Haridwar 249404, India; Princess Nourah bint Abdulrahman Univ, Coll Sci, Dept Biol, POB 84428, Riyadh 11671, Saudi Arabia; King Khalid Univ, Fac Sci & Arts, Biol Dept, Mohail Assir 61321, Saudi Arabia; Aswan Univ, Fac Sci, Bot Dept, Aswan 81528, Egypt; King Khalid Univ, Coll Sci, Biol Dept, Abha 61321, Saudi Arabia; Kafrelsheikh Univ, Fac Sci, Bot Dept, Kafr Al Sheikh 33516, Egypt | Adelodun, Bashir/O-2941-2018; AL-Huqail, Arwa A./AAZ-3925-2020; AL-Huqail, Arwa/AAZ-3925-2020; bachheti, Archana/N-5749-2017; Eid, Ebrahem/O-2723-2013; Abou Fayssal, Sami/ABF-6226-2020; Kumar, Pankaj/AAF-2231-2019 | 55233815400; 57218598581; 57193774482; 6602679448; 55934838700; 55437052500; 57221943148; 57281192700; 57192198035; 57192983622; 35794350700 | rs.pankajkumar@gkv.ac.in;ebrahem.eid@sci.kfs.edu.eg; | HORTICULTURAE | HORTICULTURAE | 2311-7524 | 9 | 3 | SCIE | HORTICULTURE | 2023 | 3.1 | 17.1 | 1.91 | 2025-06-25 | 9 | 10 | climate change; CO2 capture; greenhouse; mathematical modeling; phycoremediation; zero waste mushroom farm | BIOMASS PRODUCTION; NUTRIENT REMOVAL; PHYCOREMEDIATION; MICROALGAE; ENERGY | climate change; CO<sub>2</sub> capture; greenhouse; mathematical modeling; phycoremediation; zero waste mushroom farm | English | 2023 | 2023-03 | 10.3390/horticulturae9030308 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Sustainable Use of Sewage Sludge for Marigold (Tagetes erecta L.) Cultivation: Experimental and Predictive Modeling Studies on Heavy Metal Accumulation | The present study aimed to investigate the impact of sewage sludge (SS) amendment on the growth, yield, and biochemical attributes of the marigold (Tagetes erecta L. var. Pusa Basanti Gainda) crop. For this purpose, marigold flowers were cultivated using three different treatments of SS, i.e., 0% (control with no SS), 5%, and 10%. Multiple linear regression (MLR) modeling was performed to develop prediction models for the impact of soil properties on heavy metals uptake by marigold plants. The results showed that the growth, yield, and biochemical attributes of marigold plants significantly (p 1) showed that the marigold plant was capable of uptaking significant contents of six heavy metals in the order of Cd 0.73), model efficiency (ME > 0.49), root mean square error (RMSE < 3.25), and analysis of variance (ANOVA; p < 0.05) results. Overall, this study presented a novel approach to floriculture by sustainable management of SS while reducing public health and environmental impacts. | AL-Huqail, Arwa A.; Kumar, Pankaj; Abou Fayssal, Sami; Adelodun, Bashir; Siric, Ivan; Goala, Madhumita; Choi, Kyung Sook; Taher, Mostafa A.; El-Kholy, Aziza S.; Eid, Ebrahem M. | Princess Nourah bint Abdulrahman Univ, Coll Sci, Dept Biol, POB 84428, Riyadh 11671, Saudi Arabia; Gurukula Kangri Deemed Univ, Dept Zool & Environm Sci, Agroecol & Pollut Res Lab, Haridwar 249404, India; Univ Forestry, Fac Agron, Dept Agron, 10 Kliment Ohridski Blvd, Sofia 1797, Bulgaria; Lebanese Univ, Fac Agr, Dept Plant Prod, Beirut, Lebanon; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin 240003, Nigeria; Kyungpook Natl Univ, Dept Agr Civil Engn, Daegu 41566, South Korea; Univ Zagreb, Fac Agr, Svetosimunska 25, Zagreb 10000, Croatia; Graph Era Deemed Univ, Dept Environm Sci, Dehra Dun 248002, India; King Khalid Univ, Fac Sci & Arts, Biol Dept, Mohail Assir 61321, Saudi Arabia; Aswan Univ, Fac Sci, Bot Dept, Aswan 81528, Egypt; Kafrelsheikh Univ, Fac Sci, Bot Dept, Kafr Al Sheikh 33516, Egypt; King Khalid Univ, Coll Sci, Biol Dept, Abha 61321, Saudi Arabia | Adelodun, Bashir/O-2941-2018; Kumar, Pankaj/AAF-2231-2019; AL-Huqail, Arwa A./AAZ-3925-2020; Eid, Ebrahem/O-2723-2013; Kumar, Pankaj/AAB-4153-2019; Abou Fayssal, Sami/ABF-6226-2020; Taher, Mostafa/JNE-2285-2023; AL-Huqail, Arwa/AAZ-3925-2020 | 57192198035; 57281192700; 57218598581; 57193774482; 55233815400; 57221943148; 54392662900; 57192983622; 57212269012; 35794350700 | rs.pankajkumar@gkv.ac.in;ebrahem.eid@sci.kfs.edu.eg; | HORTICULTURAE | HORTICULTURAE | 2311-7524 | 9 | 4 | SCIE | HORTICULTURE | 2023 | 3.1 | 17.1 | 4.02 | 2025-06-25 | 22 | 22 | biochemical components; floriculture; mathematical modeling; multiple linear regression; waste management | ORGANIC-MATTER; LUTEIN CONTENT; SOIL; GROWTH; ACID; CATALASE; PROTEIN | biochemical components; floriculture; mathematical modeling; multiple linear regression; waste management | English | 2023 | 2023-04 | 10.3390/horticulturae9040447 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | T3L: A Practical Implementation of Tri-Transistor Ternary Logic Based on Inkjet-Printed Anti-Ambipolar Transistors and CMOSs of Thin-Film Structure | The imminent rise in data consumption and the physical constraints of current advanced CMOS scaling hasten the end of the projection to the binary system. For a breakthrough of these issues, the ternary system, known for its superior efficiency in expressing numbers (closest to e≈~2.7183 ) has garnered considerable attention. Among the ternary studies reported, the anti-ambipolar transistor (AAT) is acquiring attention thanks to its unique negative differential resistance (NDR) and anti-ambipolar characteristics (AAC). Moreover, easy-to-fabricate inkjet-printing based AAT was introduced. Therefore, in this paper, we propose a practical design methodology (T3L: The Tri-transistor Ternary Logic') and a set of novel ternary logic based on inkjet-printed AATs and CMOSs. In detail, 1) We propose balanced ternary full adders (BTFA) and prove that inkjet-printed AATs and CMOSs are highly capable of implementing any kind of ternary logic. 2) We propose two design methodologies for ternary logic design: NDR-based Design Method I and AAC-based Design Method II. 3) We present optimization methodology for inkjet-printed ternary circuit stability and provide circuitry to secure sufficient noise margin. We provide a highly-compact BTFA design that requires only 64 transistors and an ultra-low-power BTFA design that reduces power by 84.7% to 98.8% compared to the previous designs. © 2004-2012 IEEE. | Kim, Jongbeom; Lee, Hyundong; Ko, Jonghyun; Kim, Bongjun; Song, Taigon | Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Sookmyung Women's University, Department of Electronical Engineering, Seoul, 04312, South Korea; Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea | 57782068500; 57226892881; 59809554200; 56125116600; 36005021000 | tsong@knu.ac.kr; | IEEE Transactions on Circuits and Systems I: Regular Papers | IEEE T CIRCUITS-I | 1549-8328 | 1558-0806 | 70 | 12 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2023 | 5.2 | 17.1 | 0.12 | 2025-06-25 | 1 | anti-ambipolar transistor (AAT); Multi-valued logic; ternary full-adder; ternary logic | Adders; CMOS integrated circuits; Computer circuits; Integrated circuit design; Latexes; Low power electronics; Transistors; Ambipolar transistors; Anti-ambipolar transistor; CNTFET; Design Methodology; Full adders; Multi-valued; Multi-valued logic; Power demands; Resistance; Symbol; Ternary full-adder; Ternary logic; Many valued logics | English | Final | 2023 | 10.1109/tcsi.2023.3311034 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | The Impact of Plant Growth Regulators and Floral Cluster Thinning on the Fruit Quality of 'Shine Muscat' Grape | Plant growth regulators (PGRs) and floral cluster thinning are commonly used to improve grape yield and quality, but their effects on different fruit quality attributes in the 'Shine Muscat' are not well understood. In this study, we investigated the impact of PGRs and floral cluster thinning on various fruit quality parameters such as the cluster weight, berry weight, diameter, shape, sugar and acid content, firmness, and residual feel of peel. Our results indicate that the gibberellic acid 3 (GA(3)) 25 mg/L + thidiazuron (TDZ) 5 mg/L treatment at full bloom and GA(3) 25 mg/L treatment at 12 days after full bloom showed the largest cluster weight, berry weight, and diameter, while the forchlorfenuron (CPPU)-treated group, with a more balanced effect on fruit skin and flesh firmness, had the highest proportion of a positive residual feel of the peel. Floral cluster thinning by 4 cm was found to be effective for promoting fruit growth and maintaining an appropriate sugar-acid ratio, while thinning by 5 cm resulted in a higher number of berries but smaller berry size and lower sugar-acid ratio. These findings can be useful for grape growers and researchers in optimizing PGR and floral cluster thinning treatments to improve grape yield and quality. | Choi, Sujung; Ban, Seunghyun; Choi, Cheol | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Hort, Daegu 41566, South Korea; Gumi City Agr Technol Ctr, Gumi 39133, South Korea; Korea Inst Sci & Technol KIST, Smart Farm Res Ctr, Kangnung, Gangwon, South Korea | Ban, Seunghyun/JVP-2695-2024 | 58168746500; 56482835300; 50261314300 | banting@kist.re.kr;cc31@knu.ac.kr; | HORTICULTURAE | HORTICULTURAE | 2311-7524 | 9 | 3 | SCIE | HORTICULTURE | 2023 | 3.1 | 17.1 | 0.77 | 2025-06-25 | 4 | 4 | grape; shine muscat; plant growth regulators; fruit quality | SEEDLESS; THIDIAZURON; CPPU; STREPTOMYCIN; CYTOKININ | fruit quality; grape; plant growth regulators; shine muscat | English | 2023 | 2023-03 | 10.3390/horticulturae9030392 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The novel spore-specific regulator SscA controls Aspergillus conidiogenesis | A major group of fungi produces asexual spores (conidia) for dissemination and propagation and, in pathogenic fungi, for infection. Despite the critical role of conidia, the underlying mechanism of spore formation, integrity, and viability is not fully elucidated. In this study, we have identified and investigated the roles of the spore-specific transcription factor (TF) SscA in three Aspergillus species, including A. nidulans, A. flavus, and A. fumigatus, which is a model system, toxin producer, or a prevalent human pathogen, respectively. Comparative transcriptomic analyses have revealed that 25 TF encoding genes showed higher mRNA levels in conidia than in hyphae in three species. Functional analyses of the 25 genes have identified SscA as a key TF for conidial formation, maturation, germination, integrity, amino acid production, and secondary metabolism in Aspergillus nidulans conidia. Importantly, the roles of SscA are conserved in other Aspergillus species. Altogether, our study demonstrates that SscA is a spore-specific TF that governs the production of intact and functional conidial formation in Aspergillus species. | Son, Ye-Eun; Yu, Jae-Hyuk; Park, Hee-Soo | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; Univ Wisconsin Madison, Food Res Inst, Dept Bacteriol, Madison, WI USA; Kyungpook Natl Univ, Dept Integrat Biol, Daegu, South Korea | ; Park, Hee-Soo/AAC-6422-2019; Yu, Jae-Hyuk/A-2343-2008 | 57200513491; 7405531243; 15751448400 | phsoo97@knu.ac.kr; | MBIO | MBIO | 2150-7511 | 14 | 5 | SCIE | MICROBIOLOGY | 2023 | 5.1 | 17.1 | 1.36 | 2025-06-25 | 8 | 8 | fungi; Aspergillus; asexual spore; transcription factor; Cys(2)His(2 )domain; SscA | STRESS RESPONSES; NIDULANS; CONIDIATION; SPORULATION; METABOLISM; FUMIGATUS; PROTEINS; FUNGI | asexual spore; Aspergillus; Cys<sub>2</sub>His<sub>2</sub> domain; fungi; SscA; transcription factor | Aspergillus nidulans; Fungal Proteins; Gene Expression Profiling; Gene Expression Regulation, Fungal; Spores, Fungal; Transcription Factors; acetylene; beta glucan; caspofungin; chitin; echinocandin; genomic DNA; melanin; spore specific transcription factor; trehalose; unclassified drug; fungal protein; transcription factor; amino acid analysis; Article; Aspergillus; Aspergillus fumigatus; Aspergillus nidulans; Basidiomycetes; biogenesis; conidium; controlled study; Escherichia coli; gene expression; gene ontology; human; microscopy; nonhuman; oxidative stress; phenotype; physiological stress; real time polymerase chain reaction; RNA extraction; thin layer chromatography; transcriptome sequencing; transmission electron microscopy; Aspergillus nidulans; fungus spore; gene expression profiling; gene expression regulation; genetics; metabolism | English | 2023 | 2023-10 | 10.1128/mbio.01840-23 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Tomato Fruit Growth and Nutrient Accumulation in Response to Blue and Red Light Treatments during the Reproductive Growth Stage | Tomatoes are an important fruit consumed worldwide. Within protected cultivation environments, artificial light using energy-efficient light-emitting diodes can be applied in tomato production as an effective way to improve productivity and nutritional value. Several studies have investigated the effects of supplementing artificial light on various aspects of tomato growth, encompassing flowering, fruit development, ripening, and nutritional composition. However, the outcomes of previous studies offer inconclusive insights into whether the observed impacts on tomato growth have resulted from the provision of additional photons or discrepancies in the spectral distribution of light during artificial light supplementation. Within this context, this study aimed to specifically explore the independent effects of monochromatic blue and red light, along with their dichromatic mixture (blue + red), on fruit growth and nutrient accumulation in comparison with multispectral white light. These four different light treatments were implemented after anthesis under the same photosynthetic photon flux density to mitigate possible variabilities arising from different light intensities and originating during the vegetative growth stage. As a result, under the same light intensity conditions, red and blue + red light irradiance during the reproductive growth stage delayed fruit ripening by up to 4.33 days compared to white light. Regarding fruit productivity, the fresh weight of fully ripe tomato fruit in the blue, red, or blue + red light treatment groups was not different from that in the white-light treatment group, whereas the blue light treatment significantly reduced the number of fruits in the plant. Finally, nutrient content, including soluble sugars, lycopene, and beta-carotene, significantly increased by 10.0%, 27.1%, and 65.2%, respectively, in the blue compared to the white light-irradiated group. This study demonstrated that the application of distinct light spectra during the reproductive growth phase could have varying impacts on tomato fruit development and nutrient accumulation. By integrating our findings with results from prior studies, a more efficient light intervention strategy could be developed to effectively regulate traits of tomato fruit within an indoor production system. | Lee, Su Hyeon; Won, Hyo Jun; Ban, Seunghyun; Choi, Hyelim; Jung, Je Hyeong | Korea Inst Sci & Technol KIST, Smart Farm Res Ctr, Kangnung 25451, South Korea; Univ Sci & Technol UST, KIST Sch, Div Biomed Sci & Technol, Daejeon 34113, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Hort, Daegu 41566, South Korea | ; Jung, Je Hyeong/G-8604-2014; Lee, Suhyeon/LSK-3027-2024; JUNG, JE/G-8604-2014 | leesh@kist.re.kr;hjwon7943@ust.ac.kr;choihl2727@kist.re.kr;jhjung@kist.re.kr; | HORTICULTURAE | HORTICULTURAE | 2311-7524 | 9 | 10 | SCIE | HORTICULTURE | 2023 | 3.1 | 17.1 | 4 | beta-carotene; fruit development; light modulation; light intensity; light quality; lycopene | METABOLISM; TIME | English | 2023 | 2023-10 | 10.3390/horticulturae9101113 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Review | Utilizing databases for astrocyte secretome research | IntroductionAstrocytes are the most abundant cell type in the central nervous system (CNS). They play a pivotal role in supporting neuronal function and maintaining homeostasis by releasing a variety of bioactive proteins, collectively known as the astrocyte secretome. Investigating secretome provides insights into the molecular mechanisms underlying astrocyte function and dysfunction, as well as novel strategies to prevent and treat diseases affecting the CNS.Areas coveredProteomics databases are a valuable resource for studying the role of astrocytes in healthy and diseased brain function, as they provide information about gene expression, protein expression, and cellular function. In this review, we discuss existing databases that are useful for astrocyte secretome research.Expert opinionAstrocyte secretomics is a field that is rapidly progressing, yet the availability of dedicated databases is currently limited. To meet the increasing demand for comprehensive omics data in glia research, developing databases specifically focused on astrocyte secretome is crucial. Such databases would allow researchers to investigate the intricate molecular landscape of astrocytes and comprehend their involvement in diverse physiological and pathological processes. Expanding resources through the development of databases dedicated to the astrocyte secretome may facilitate further advancements in this field. | Afridi, Ruqayya; Lee, Won-Ha; Kim, Jong-Heon; Suk, Kyoungho | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat Biores Grp, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 57200759784; 57205609794; 57203324811; 7005114595 | jongheonkim@knu.ac.kr;ksuk@knu.ac.kr; | EXPERT REVIEW OF PROTEOMICS | EXPERT REV PROTEOMIC | 1478-9450 | 1744-8387 | 20 | 12 | SCIE | BIOCHEMICAL RESEARCH METHODS | 2023 | 3.8 | 17.1 | 0.06 | 2025-06-25 | 1 | 1 | Astrocyte; central nervous system; database; proteomics; secretome | PROTEOMICS; CELLS; GLIA; TRANSCRIPTOME; RESOURCE; NEURONS; RNA | Astrocyte; central nervous system; database; proteomics; secretome | Astrocytes; Humans; Neuroglia; Neurons; Proteins; Secretome; proteome; transcriptome; protein; Alzheimer disease; astrocyte; brain function; brain tissue; cell function; cells by body anatomy; cerebrospinal fluid; data base; gene expression; glia; human; multiomics; nomenclature; nonhuman; protein expression; proteomics; research; Review; RNA sequencing; secretome; single cell RNA seq; standardization; metabolism; nerve cell | English | 2023 | 2023-12-02 | 10.1080/14789450.2023.2285311 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Dynamic nature and prognostic value of the neutrophil-to-lymphocyte ratio in critically ill patients with acute kidney injury on continuous renal replacement therapy: A multicenter cohort study | IntroductionPatients with acute kidney injury (AKI) receiving renal replacement therapy constitute the subgroup of AKI with the highest risk of mortality. Despite recent promising findings on the neutrophil-to-lymphocyte ratio (NLR) in AKI, studies have not yet addressed the clinical implication of the NLR in this population. Therefore, we aimed to examine the prognostic value of NLR in critically ill patients requiring continuous renal replacement therapy (CRRT), especially focusing on temporal changes in NLR. MethodsWe enrolled 1,494 patients with AKI who received CRRT in five university hospitals in Korea between 2006 and 2021. NLR fold changes were calculated as the NLR on each day divided by the NLR value on the first day. We performed a multivariable Cox proportional hazard analysis to assess the association between the NLR fold change and 30-day mortality. ResultsThe NLR on day 1 did not differ between survivors and non-survivors; however, the NLR fold change on day 5 was significantly different. The highest quartile of NLR fold change during the first 5 days after CRRT initiation showed a significantly increased risk of death (hazard ratio [HR], 1.65; 95% confidence intervals (CI), 1.27-2.15) compared to the lowest quartile. NLR fold change as a continuous variable was an independent predictor of 30-day mortality (HR, 1.14; 95% CI, 1.05-1.23). ConclusionIn this study, we demonstrated an independent association between changes in NLR and mortality during the initial phase of CRRT in AKI patients receiving CRRT. Our findings provide evidence for the predictive role of changes in the NLR in this high-risk subgroup of AKI. | Ko, Hyun Lee; Jung, Jiyun; Lee, Jangwook; Lim, Jeong-Hoon; Im, Dha Woon; Kim, Yong Chul; Paek, Jin Hyuk; Park, Woo Yeong; Kim, Kyeong Min; Lee, Soyoung; Lee, Sung Woo; Shin, Sung Joon; Kim, Dong Ki; Han, Seung Seok; Baek, Chung Hee; Kim, Hyosang; Park, Jae Yoon; Ban, Tae Hyun; Kim, Kipyo | Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Internal Med, Uijongbu, Gyeonggi Do, South Korea; Dongguk Univ, Clin Trial Ctr, Ilsan Hosp, Goyang, South Korea; Dongguk Univ, Res Ctr Chron Dis & Environm Med, Coll Med, Gyeongju, South Korea; Dongguk Univ, Dept Internal Med, Ilsan Hosp, Goyang, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Nephrol, Daegu, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Keimyung Univ, Dept Internal Med, Dongsan Med Ctr, Daegu, South Korea; Eulji Univ, Daejeon Eulji Med Ctr, Dept Internal Med, Daejeon, South Korea; Dongguk Univ, Dept Internal Med, Coll Med, Gyeongju, South Korea; Univ Ulsan, Asan Med Ctr, Dept Internal Med, Coll Med, Seoul, South Korea; Catholic Univ Korea, Eunpyeong St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Inha Univ, Inha Univ Hosp, Dept Internal Med, Coll Med, Incheon, South Korea | Lim, Jeong-Hoon/ABE-6003-2020; Park, Woo Yeong/AGK-9140-2022; Han, Seung/W-8825-2019; Kim, Yong/L-8653-2019 | 57738143600; 57211813518; 57223232128; 55360244300; 58175957300; 57026583000; 57205473062; 36344980100; 57199438486; 57221452791; 56708181900; 55662651000; 23479259100; 35242581200; 55013637800; 57190118848; 56603383500; 56119751700; 57164118000 | deux0123@catholic.ac.kr;kpkidney@inha.ac.kr; | FRONTIERS IN MEDICINE | FRONT MED-LAUSANNE | 2296-858X | 10 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3.1 | 17.2 | 0.51 | 2025-06-25 | 3 | 3 | acute kidney injury; continuous renal replacement therapy; neutrophil-to-lymphocyte ratio; inflammation; biomarker | SEPTIC SHOCK; OUTCOMES; FAILURE; SEPSIS; AKI; LYMPHOPENIA | acute kidney injury; biomarker; continuous renal replacement therapy; inflammation; neutrophil-to-lymphocyte ratio | acute kidney failure; aged; Article; cohort analysis; continuous renal replacement therapy; controlled study; critically ill patient; female; human; Korea; major clinical study; male; mortality rate; neutrophil lymphocyte ratio; prognosis; retrospective study; survivor; university hospital | English | 2023 | 2023-03-28 | 10.3389/fmed.2023.1162381 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Macrophages promote Fibrinogenesis during kidney injury | Macrophages (Mo) are widely considered fundamental in the development of kidney fibrosis since Mo accumulation commonly aggravates kidney fibrosis, while Mo depletion mitigates it. Although many studies have aimed to elucidate Mo-dependent mechanisms linked to kidney fibrosis and have suggested various mechanisms, the proposed roles have been mostly passive, indirect, and non-unique to Mo. Therefore, the molecular mechanism of how Mo directly promote kidney fibrosis is not fully understood. Recent evidence suggests that Mo produce coagulation factors under diverse pathologic conditions. Notably, coagulation factors mediate fibrinogenesis and contribute to fibrosis. Thus, we hypothesized that kidney Mo express coagulation factors that contribute to the provisional matrix formation during acute kidney injury (AKI). To test our hypothesis, we probed for Mo-derived coagulation factors after kidney injury and uncovered that both infiltrating and kidney-resident Mo produce non-redundant coagulation factors in AKI and chronic kidney disease (CKD). We also identified F13a1, which catalyzes the final step of the coagulation cascade, as the most strongly upregulated coagulation factor in murine and human kidney Mo during AKI and CKD. Our in vitro experiments revealed that the upregulation of coagulation factors in Mo occurs in a Ca2 + -dependent manner. Taken together, our study demonstrates that kidney Mo populations express key coagulation factors following local injury, suggesting a novel effector mechanism of Mo contributing to kidney fibrosis. | Oh, Hanna; Kwon, Ohbin; Kong, Min Jung; Park, Kwon Moo; Baek, Jea-Hyun | Handong Global Univ, Lab Inflammat Res, Pohang, Gyeongbuk, South Korea; Handong Global Univ, Sch Life Sci, Pohang, Gyeongbuk, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Sch Med, Dept Anat,BK21Plus, Daegu, South Korea | ; Baek, Jea Hyun/J-2752-2019 | 59586775000; 58482625800; 57194730911; 8785448200; 24464467400 | jbaek@handong.edu; | FRONTIERS IN MEDICINE | FRONT MED-LAUSANNE | 2296-858X | 10 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3.1 | 17.2 | 0.26 | 2025-06-25 | 3 | 2 | kidney fibrosis; chronic kidney disease; macrophages; coagulation factor; fibrinogenesis | COAGULATION; FIBROSIS; RESIDENT; PAI-1; MICE | chronic kidney disease; coagulation factor; fibrinogenesis; kidney fibrosis; macrophages | blood clotting factor; blood clotting factor 13a; calcium ion; interleukin 13; interleukin 4; ketamine; xylazine; acute kidney failure; animal cell; animal experiment; animal model; animal tissue; Article; chronic kidney failure; controlled study; differential gene expression; female; fibrin formation; flow cytometry; human; immunofluorescence; in vitro study; kidney fibrosis; kidney proximal tubule; kidney tissue; macrophage; microaneurysm; molecular pathology; mouse; nonhuman; protein blood level; real time polymerase chain reaction; renal artery occlusion; reverse transcription; single cell RNA seq; upregulation | English | 2023 | 2023-06-22 | 10.3389/fmed.2023.1206362 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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