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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Metabolic Regulation of Glial Phenotypes: Implications in Neuron-Glia Interactions and Neurological Disorders | Glial cells are multifunctional, non-neuronal components of the central nervous system with diverse phenotypes that have gained much attention for their close involvement in neuroinflammation and neurodegenerative diseases. Glial phenotypes are primarily characterized by their structural and functional changes in response to various stimuli, which can be either neuroprotective or neurotoxic. The reliance of neurons on glial cells is essential to fulfill the energy demands of the brain for its proper functioning. Moreover, the glial cells perform distinct functions to regulate their own metabolic activities, as well as work in close conjunction with neurons through various secreted signaling or guidance molecules, thereby constituting a complex network of neuron-glial interactions in health and disease. The emerging evidence suggests that, in disease conditions, the metabolic alterations in the glial cells can induce structural and functional changes together with neuronal dysfunction indicating the importance of neuron-glia interactions in the pathophysiology of neurological disorders. This review covers the recent developments that implicate the regulation of glial phenotypic changes and its consequences on neuron-glia interactions in neurological disorders. Finally, we discuss the possibilities and challenges of targeting glial metabolism as a strategy to treat neurological disorders. | Afridi, Ruqayya; Kim, Jong-Heon; Rahman, Md Habibur; Suk, Kyoungho | Kyungpook Natl Univ, Sch Med, BK21 Plus KNU Biomed Convergence Program, Brain Sci & Engn Inst,Dept Pharmacol, Daegu, South Korea | Rahman, Md Habibur/HMD-4572-2023 | 57200759784; 57203324811; 59607139800; 7005114595 | ksuk@knu.ac.kr; | FRONTIERS IN CELLULAR NEUROSCIENCE | FRONT CELL NEUROSCI | 1662-5102 | 14 | SCIE | NEUROSCIENCES | 2020 | 5.505 | 22.9 | 1.42 | 2025-06-25 | 65 | 69 | neuron; glia; metabolism; neuron-glia interaction; neurological disorders | MODULATES MICROGLIAL ACTIVATION; MULTIPLE-SCLEROSIS; OXIDATIVE-METABOLISM; ENERGY-METABOLISM; GENE-EXPRESSION; IN-VIVO; MITOCHONDRIAL DYSFUNCTION; NEUROPROTECTIVE FUNCTIONS; DISEASE PROGRESSION; ALZHEIMERS-DISEASE | glia; metabolism; neurological disorders; neuron; neuron–glia interaction | brain ischemia; cell function; cell interaction; cell metabolism; cellular secretion; degenerative disease; demyelinating disease; drug targeting; glia cell; human; metabolic disorder; metabolic regulation; metabolite; nerve cell; neurologic disease; nonhuman; phenotype; protein aggregation; Review | English | 2020 | 2020-02-11 | 10.3389/fncel.2020.00020 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Microencapsulation of stearic acid with SiO2 shell as phase change material for potential energy storage | Stearic acid (SA) is being used as phase change material (PCM) in energy storage applications. In the present study, the microencapsulation of SA with SiO2 shell was carried out by sol-gel method. Different amounts of SA (5, 10, 15, 20, 30 and 50 g) were taken against 10 ml of tetraethyl orthosilicate (TEOS) for encapsulation. The synthesized microencapsulated PCM (MEPCM) were characterized by Fourier transform infrared spectroscope (FT-IR), X-Ray diffraction (XRD), X-Ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The characterization results showed that SA was successfully encapsulated by SiO2. Thermogravimetric analysis (TGA) exhibited better thermal stability of the MEPCM than SA. The enthalpy values of MEPCM were found to be unchanged even after 30 heating-cooling cycles by differential scanning calorimetry (DSC). The latent heats of melting and solidification of 50 g SA containing MEPCM were found to be highest i.e. 182.53 J/g and 160.12 J/g, respectively among all microencapsulated samples. The encapsulation efficiency values were calculated using thermal data and the efficiency was found to be highest i.e. 86.68% in the same sample. | Ishak, Shafiq; Mandal, Soumen; Lee, Han-Seung; Singh, Jitendra Kumar | Hanyang Univ, Dept Architectural Engn, 1271 Sa 3 Dong, Ansan 15588, South Korea; Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea; Hanyang Univ, Dept Architectural Engn, Innovat Durable Bldg & Infrastruct Res Ctr, 1271 Sa 3 Dong, Ansan 15588, South Korea | Singh, Jitendra/AAU-6579-2021; Mandal, Soumen/AAB-3917-2021; Lee, HanSeung/E-9087-2013; Lee, Han-Seung/E-9087-2013; Ishak, Shafiq/ABC-3063-2020 | 57218951467; 57214752240; 57956643400; 57197846307 | ercleehs@hanyang.ac.kr;jk200386@hanyang.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 1.18 | 2025-06-25 | 50 | 57 | HEAT-TRANSFER CHARACTERISTICS; N-OCTADECANE; INTERFACIAL POLYMERIZATION; THERMAL PERFORMANCE; AMMONIUM PHOSPHATE; POLYURETHANE SHELL; FACILE SYNTHESIS; COMPOSITE; FABRICATION; SILICA | English | 2020 | 2020-09-14 | 10.1038/s41598-020-71940-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Review | Microglia Gone Awry: Linking Immunometabolism to Neurodegeneration | Age-related chronic inflammatory activation of microglia and their dysfunction are observed in many neurodegenerative diseases, and the potential contributions of these dysfunctional cells to neurodegeneration have been demonstrated recently. The housekeeping and defensive functions of microglia, such as surveying the brain parenchyma and phagocytosis of neuronal debris after injury, are important for brain homeostasis and immunity. During neurodegenerative diseases, loss of these functions can promote disease pathology by producing proinflammatory cytokines and increasing oxidative stress, which can exaggerate the ongoing neuroinflammation. A recent surge in microglial research has unraveled myriads of microglial phenotypes associated with aging and neurodegenerative diseases, in addition to the conventional M1/M2 paradigm. Each of these phenotypes can be characterized by distinct transcriptional profiles as well as altered metabolism, migration, and phagocytosis characteristics. Mutations in triggering receptor expressed on myeloid cells 2 (Trem2) and granulin (GRN) are associated with various neurodegenerative diseases, and these genes are dysregulated in the majority of recently identified microglial phenotypes. These genes act as checkpoint regulators and maintain microglial inflammatory fitness, principally through metabolic modulation. Dysfunctional microglia typically show mitochondrial deficits, glycolysis elevation, and lipid droplet accumulation, which results in reduced migration and phagocytosis and increased proinflammatory cytokine secretion and reactive oxygen species release. In this mini-review article, we discuss the existing data regarding metabolic perturbations in dysfunctional microglia and their documented associations with neurodegeneration, highlighting how aging-induced chronic microglial activation alters microglial bioenergetics, leading to impaired homeostatic and housekeeping functions. Dysfunctional microglia initiate or exacerbate neurodegeneration, and key pathways involved in the dysfunctional processes, including metabolism, may represent potential intervention targets for correcting imbalances. | Afridi, Ruqayya; Lee, Won-Ha; Suk, Kyoungho | Kyungpook Natl Univ, Brain Sci & Engn Inst, Plus KNU Biomed Convergence Program BK21, Dept Pharmacol,Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, Plus KNU Creat BioRes Grp BK21, Daegu, South Korea | 57200759784; 57205609794; 7005114595 | ksuk@knu.ac.kr; | FRONTIERS IN CELLULAR NEUROSCIENCE | FRONT CELL NEUROSCI | 1662-5102 | 14 | SCIE | NEUROSCIENCES | 2020 | 5.505 | 22.9 | 0.77 | 2025-06-25 | 41 | 43 | microglia; phenotype; neurodegeneration; neuroinflammation; metabolism; oxidative stress; homeostatic function | TREM2; PROGRANULIN; DISEASE; GENES | homeostatic function; metabolism; microglia; neurodegeneration; neuroinflammation; oxidative stress; phenotype | apolipoprotein A1; apolipoprotein E; arginase 1; c type lectin domain family 7; carbohydrate; chemokine receptor CX3CR1 antagonist; cholesterol acyltransferase; cholesterol esterase; fat droplet; gamma interferon; glucose; granulin; ibuprofen; interleukin 13; interleukin 1beta; interleukin 6; macrophage inflammatory protein 1alpha; mammalian target of rapamycin; myocyte specific enhancer factor 2a; neutral cholesterol ester hydrolase; olfactomedin like 3; progranulin; protein; purinergic P2Y12 receptor; pyruvate dehydrogenase kinase 1; reactive oxygen metabolite; serine threonine protein kinase b; sorting nexin 17; toll like receptor 2; transmembrane immune signaling adaptor; transmembrane protein 119; triggering receptor expressed on myeloid cells 2; tumor necrosis factor; unclassified drug; aging; Alzheimer disease; amyotrophic lateral sclerosis; brain blood flow; brain damage; carbohydrate metabolism; cytokine release; demyelinating disease; down regulation; electron microscopy; gene expression; glucose metabolism; glycolysis; homeostasis; housekeeping gene; human; inflammation; lipid metabolism; lysosome storage disease; microenvironment; microglia; nerve degeneration; nervous system inflammation; neurotoxicity; obsessive compulsive disorder; oxidative phosphorylation; oxidative stress; Parkinson disease; phagocytosis; phenotype; protein phosphorylation; Review; single cell RNA seq | English | 2020 | 2020-08-13 | 10.3389/fncel.2020.00246 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Molecular phylogenetic, population genetic and demographic studies of Nodularia douglasiae and Nodularia breviconcha based on CO1 and 16S rRNA | Freshwater mussels belonging to the genus Nodularia (Family Unionidae) are known to be widely distributed in East Asia. Although phylogenetic and population genetic studies have been performed for these species, there still remain unresolved questions in their taxonomic status and biogeographic distribution pathways. Here, the nucleotide sequences of CO1 and 16S rRNA were newly determined from 86 N. douglasiae and 83 N. breviconcha individuals collected on the Korean Peninsula. Based on these data, we revealed the following results: (1) N. douglasiae can be divided into the three genetic clades of A (only found in Korean Peninsula), B (widely distributed in East Asia), and C (only found in the west of China and Russia), (2) the clade A is not an independent species but a concrete member of N. douglasiae given the lack of genetic differences between the clades A and B, and (3) N. breviconcha is not a subspecies of N. douglasiae but an independent species apart from N. douglasiae. In addition, we suggested the plausible scenarios of biogeographic distribution events and demographic history of Nodularia species. | Choi, Eun Hwa; Kim, Gyeongmin; Cha, Seung Hyun; Lee, Jun-Sang; Ryu, Shi Hyun; Suk, Ho Young; Lee, Young Sup; Baek, Su Youn; Hwang, Ui Wook | Kyungpook Natl Univ, Dept Biol Educ, Teachers Coll, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Phylogen & Evolut, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Korean Herb Bio Convergence Promot, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, Grad Sch, Daegu 41566, South Korea; Soonchunhyang Univ, Coll Nat Sci, Dept Life Sci & Biotechnol, Asan 31538, Chungcheongnam, South Korea; Nakdonggang Natl Inst Biol Resources, Freshwater Biodivers Res Div, Sangju 37242, Gyeongsangbuk D, South Korea; Yeungnam Univ, Dept Life Sci, Gyongsan 38541, Gyeongsangbuk D, South Korea | Choi, Eun Hwa/HTN-1610-2023 | 57203556599; 57211378109; 57203435784; 54397432400; 23467744800; 7005704783; 36013628200; 57192371420; 35074015800 | sybaek7@knu.ac.kr;uwhwang1@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.36 | 2025-06-25 | 16 | 16 | CONTINENTAL-SHELF WIDTH; BIVALVIA UNIONIDA; MITOCHONDRIAL GENOME; MOLLUSCA-BIVALVIA; UNIONOIDA; EVOLUTION; PATTERNS; UTILITY; GROWTH | Animals; Base Sequence; Far East; Genetics, Population; Nodularia; Phylogeny; RNA, Ribosomal, 16S; Russia; Species Specificity; Unionidae; RNA 16S; animal; classification; Far East; genetics; Nodularia; nucleotide sequence; phylogeny; population genetics; Russian Federation; species difference; Unionidae | English | 2020 | 2020-10-06 | 10.1038/s41598-020-72015-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Neural maturation enhanced by exercise-induced extracellular derivatives | Physical activity has profound effects on neuronal progenitor cell growth, differentiation, and integration, but the mechanism for these effects is still ambiguous. Using a mouse model, we investigated the effects of two weeks of treadmill running on the dynamics of the size distribution and miRNA profiles of serum extracellular derivatives (EDs) using particle-sizing analysis and small RNA sequencing. We found that an increased average diameter of EDs in the running group compared with the sedentary group (p<0.05), and 16 miRNAs were significantly altered (p<0.05) in the running group. Furthermore, functional annotation analysis of differentially expressed miRNA-predicted target genes showed that many of these target genes are involved in the PI3K-Akt pathway. Exercise-induced serum EDs increased Neuro2A cell viability and Akt phosphorylation. We also found that expression levels of neuronal maturation markers such as Microtubule-Associated Protein 2 (MAP2ab) and Neuronal nuclei (NeuN) were increased (p<0.05, respectively), and that inhibition of the PI3K-Akt pathway by LY294002 pre-treatment ameliorated their expression in Neuro2A cells. Finally, the administration of exercise-induced EDs for 3 days increased the Histone 3 phosphorylation and beta-III tubulin expression in Ink/Arf null neural stem cells and progenitors (NSPCs) under each proliferation and differentiation condition. These results suggest that exercise-induced circulating EDs may mediate neuronal maturation during exercise. | Moon, Hyo Youl; Yoon, Kyeong Jin; Lee, Won Sang; Cho, Hae-Sung; Kim, Yeon; Kim, Ji-Seok | Seoul Natl Univ, Dept Phys Educ, Seoul, South Korea; Seoul Natl Univ, Inst Sport Sci, Seoul 08826, South Korea; Seoul Natl Univ, Sch Biol Sci, Seoul 08826, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Brain Sci & Engn Inst, Daegu 41940, South Korea; Gyeongsang Natl Univ, Dept Phys Educ, Jinju Daero 52828, Jinju, South Korea | cho, hae-sung/AAG-8548-2020 | 55214670600; 57205136851; 57213009842; 57214369079; 57203012542; 57203539565 | kjs7952@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.27 | 2025-06-25 | 6 | 7 | ANTIDEPRESSANT ACTIONS; CELL-PROLIFERATION; SKELETAL-MUSCLE; DIFFERENTIATION; MOUSE; NEUROGENESIS; RESISTANCE; MICRORNAS; NETWORK; PROTEINS | Animals; Brain; Cell Line; Cell Proliferation; Cell Survival; Extracellular Space; Hand Strength; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Motor Activity; Neurons; Particle Size; Phosphatidylinositol 3-Kinases; Phosphorylation; Physical Conditioning, Animal; Proto-Oncogene Proteins c-akt; Running; microRNA; phosphatidylinositol 3 kinase; protein kinase B; animal; animal experiment; brain; C57BL mouse; cell line; cell proliferation; cell survival; cytology; extracellular space; genetics; growth, development and aging; hand strength; male; metabolism; motor activity; mouse; nerve cell; particle size; phosphorylation; physiology; running | English | 2020 | 2020-03-03 | 10.1038/s41598-020-60930-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Odor habituation can modulate very early olfactory event-related potential | Odor habituation is a phenomenon that after repeated exposure to an odor, is characterized by decreased responses to it. The central nervous system is involved in odor habituation. To study odor habituation in humans, measurement of event-related potentials (ERPs) has been widely used in the olfactory system and other sensory systems, because of their high temporal resolution. Most previous odor habituation studies have measured the olfactory ERPs of (200-800) ms. However, several studies have shown that the odor signal is processed in the central nervous system earlier than at 200 ms. For these reasons, we studied whether when odors were habituated, olfactory ERP within 200 ms of odors could change. To this end, we performed an odor habituation behavior test and electroencephalogram experiments. In the behavior test, under habituation conditions, odor intensity was significantly decreased. We found significant differences in the negative and positive potentials within 200 ms across the conditions, which correlated significantly with the results of the behavior test. We also observed that ERP latency depended on the conditions. Our study suggests that odor habituation can involve the olfactory ERP of odors within 200 ms in the brain. | Kim, Kwangsu; Bae, Jisub; Jin, Youngsun; Moon, Cheil | Daegu Gyeungbuk Inst Sci & Technol DGIST, Grad Sch, Dept Brain & Cognit Sci, 333 Techno Jung Ang Daero, Daegu 711873, South Korea; Kyungpook Natl Univ, Dept Psychol, Coll Social Sci, Daegu, South Korea; Daegu Gyeongbuk Inst Sci & Technol DGIST, Convergence Res Adv Ctr Olfact, Daegu, South Korea | 57219555648; 56682426800; 57219548068; 7202189083 | cmoon@dgist.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.32 | 2025-06-25 | 8 | 10 | Adult; Animals; Brain; Evoked Potentials; Habituation, Psychophysiologic; Humans; Male; Odorants; Olfactory Pathways; Smell; Young Adult; fragrance; article; controlled study; electroencephalogram; event related potential; habituation; human; odor; adult; animal; brain; evoked response; habituation; male; odor; olfactory system; physiology; young adult | English | 2020 | 2020-10-22 | 10.1038/s41598-020-75263-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Overexpression of OsCM alleviates BLB stress via phytohormonal accumulation and transcriptional modulation of defense-related genes in Oryza sativa | Xanthomonas oryzae is a serious pathogen causing bacterial leaf blight (BLB) disease in rice, markedly reducing its yield. In this study, the rice chorismate mutase (OsCM) gene was overexpressed in a bacterial leaf blight-susceptible rice line to investigate the functional role of OsCM in response to bacterial leaf blight stress. We reported that overexpression of OsCM altered the downstream pathway of aromatic amino acids, mitigating pathogen stress by altering stress-responsive genes and hormonal accumulation. Phenotypic evaluation showed that the lesion length in the transgenic line was significantly lesser than that in the wild-type, suggesting greater resistance in the transgenic line. Further analysis revealed that OsCM expression induced phenylalanine accumulation and suppressed tyrosine accumulation in response to bacterial leaf blight stress. Furthermore, bacterial leaf blight stress induced genes downstream of the phenylpropanoid pathway in conjunction with OsCM, suggesting that the phenylpropanoid pathway is dependent on OsCM gene expression. We reported high SA and low JA accumulation in response to bacterial leaf blight stress in the transgenic line. This higher SA accumulation suggested that SA induces immune responses by functioning as a promoter of nonexpresser pathogenesis-related genes 1 (NPR1) transcriptional regulation. Xa7 expression was induced with increase in nonexpresser pathogenesis-related genes 1, which is thought to be responsible for Xa7 expression, which is responsible for mitigating bacterial leaf blight stress. | Jan, Rahmatullah; Khan, Muhammad Aaqil; Asaf, Sajjad; Lee, In-Jung; Bae, Jong-Sup; Kim, Kyung-Min | Kyungpook Natl Univ, Div Plant Biosci, Sch Appl Biosci, Coll Agr & Life Sci, 80 Dahak Ro, Daegu 41566, South Korea; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Kyungpook Natl Univ, Coll Pharm, CMRI, Res Inst Pharmaceut Sci,BK21 Plus KNU Multiom Bas, Daegu 41566, South Korea | Jan, Rahmatullah/AIC-3439-2022; Kim, Kyung-Min Kim/C-7007-2014; Asaf, Sajjad/ABA-3647-2021; Khan, Muhammad/ABB-9797-2021; Bae, Jong-Sup/AAU-9724-2020; Lee, In-Jung/GLS-0432-2022 | 57201981969; 57188585606; 56595059900; 16425830900; 16021543200; 34868260300 | baejs@knu.ac.kr;kkm@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.68 | 2025-06-25 | 17 | 18 | PHENYLALANINE-AMMONIA-LYASE; SYSTEMIC ACQUIRED-RESISTANCE; BACTERIAL-BLIGHT RESISTANCE; SALICYLIC-ACID; ARABIDOPSIS-THALIANA; DISEASE RESISTANCE; PLANT DEFENSES; BIOSYNTHESIS; PATHOGENS; RESPONSES | Chorismate Mutase; Cloning, Molecular; Disease Resistance; Gene Expression Regulation, Plant; Lignin; Oryza; Phenylalanine; Phenylalanine Ammonia-Lyase; Plant Diseases; Plant Growth Regulators; Plant Proteins; Plants, Genetically Modified; Salicylic Acid; Stress, Physiological; Transcription, Genetic; Tyrosine; Xanthomonas; chorismate mutase; lignin; phenylalanine; phenylalanine ammonia lyase; phytohormone; plant protein; salicylic acid; tyrosine; disease resistance; gene expression regulation; genetic transcription; genetics; metabolism; microbiology; molecular cloning; Oryza; pathogenicity; physiological stress; physiology; plant disease; transgenic plant; Xanthomonas | English | 2020 | 2020-11-11 | 10.1038/s41598-020-76675-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Overexpression of OsF3H modulates WBPH stress by alteration of phenylpropanoid pathway at a transcriptomic and metabolomic level in Oryza sativa | The whitebacked planthopper (WBPH), has become a devastating pest for rice crops, causes serious yield losses each year, and urgently needs biological control. Here, we developed a WBPH-resistant rice cultivar by overexpressing the OsF3H gene. A genetic functional analysis of the OsF3H gene confirmed its role in facilitating flavonoid contents and have indicated that the expression of the OsF3H gene is involved in regulation of the downstream genes (OsDFR and OsFLS) of the flavonoid pathway and genes (OsSLR1 and OsWRKY13) involved in other physiological pathways. OxF3H (OsF3H transgenic) plants accumulated significant amounts of the flavonols kaempferol (Kr) and quercetin (Qu) and the anthocyanins delphinidin and cyanidin, compared to the wild type, in response to the stress induced by WBPH. Similarly, OsF3H-related proteins were significantly expressed in OxF3H lines after WBPH infestation. The present study, indicated that the regulation of JA in OxF3H plants was suppressed due the overexpression of the OsF3H gene, which induced the expression of downstream genes related to anthocyanin. Similarly, the OsWRKY13 transcriptional factor was significantly suppressed in OxF3H plants during WBPH infestation. Exogenous application of Kr and Qu increased the survival rates of susceptible TN1 lines in response to WBPH, while decreased the survival rate of first instar WBPHs, indicating that both flavonols exhibit pesticide activity. Phenotypic demonstration also affirms that OxF3H plants show strong resistance to WBPH compared with wild type. Collectively, our result suggested that OsF3H overexpression led to the up-regulation of defense related genes and enhanced rice resistance to WBPH infestation. | Jan, Rahmatullah; Khan, Muhammad Aqil; Asaf, Sajjad; Lee, In-Jung; Kim, Kyung-Min | Kyungpook Natl Univ, Sch Appl Biosci, Div Plant Biosci, Coll Agr & Life Sci, 80 Dahak Ro, Daegu 41566, South Korea; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman | ; Jan, Rahmatullah/AIC-3439-2022; Kim, Kyung-Min Kim/C-7007-2014; Lee, In-Jung/GLS-0432-2022; Khan, Muhammad/ABB-9797-2021; Asaf, Sajjad/ABA-3647-2021 | 57201981969; 57188585606; 56595059900; 16425830900; 34868260300 | kkm@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 1.54 | 2025-06-25 | 41 | 42 | PLANTHOPPER SOGATELLA-FURCIFERA; BROWN PLANTHOPPER; OXIDATIVE STRESS; ANTHOCYANIN BIOSYNTHESIS; NILAPARVATA-LUGENS; PLANT INTERACTIONS; STRUCTURAL GENES; RICE; ARABIDOPSIS; FLAVONOIDS | Animals; Flavonoids; Gene Expression Regulation, Plant; Hemiptera; Host-Parasite Interactions; Metabolic Networks and Pathways; Metabolome; Mixed Function Oxygenases; Oryza; Plant Diseases; Plant Proteins; Transcriptome; Up-Regulation; flavanone 3-dioxygenase; flavonoid; mixed function oxidase; plant protein; transcriptome; animal; gene expression regulation; genetics; Hemiptera; host parasite interaction; metabolism; metabolome; Oryza; parasitology; physiology; plant disease; upregulation | English | 2020 | 2020-09-07 | 10.1038/s41598-020-71661-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Parvalbumin-, substance P- and calcitonin gene-related peptide-immunopositive axons in the human dental pulp differ in their distribution of varicosities | Information on the frequency and spatial distribution of axonal varicosities associated with release of neurotransmitters in the dental pulp is important to help elucidate the peripheral mechanisms of dental pain, mediated by myelinated versus unmyelinated fibers. For this, we investigated the distribution of axonal varicosities in the human dental pulp using light- and electron-microscopic immunohistochemistry for the vesicular glutamate transporter 2 (VGLUT2), which is involved in the glutamatergic transmission, and syntaxin-1 and synaptosomal nerve-associated protein 25 (SNAP-25), combined with parvalbumin (PV), which is expressed mostly in myelinated axons, and substance P (SP) and calcitonin gene-related peptide (CGRP), which are expressed mostly in unmyelinated axons. We found that the varicosities of the SP- and CGRP-immunopositive (+) axons were uniformly distributed throughout the dental pulp, whereas those of PV+ axons were only dense in the peripheral pulp, and that the expression of PV, VGLUT2, syntaxin-1, SNAP-25, SP and CGRP was significantly higher in the varicosities than in the axonal segments between them. These findings are consistent with the release of glutamate and neuropeptides by axonal varicosities of SP+ and CGRP+ unmyelinated fibers, involved in pulpal pain throughout the human dental pulp, and by varicosities of PV+ fibers, arising from parent myelinated fibers, and involved in dentin sensitivity primarily in the peripheral pulp. | Park, Sook Kyung; Choi, Seung Ki; Kim, Youn Gyung; Choi, So Young; Kim, Jin Wook; Seo, Sang Hyeok; Lee, Ji Hyun; Bae, Yong Chul | Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, 188-1,2 Ga, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Daegu 41940, South Korea | 37099111300; 57208393923; 57217360214; 57202918688; 55862646000; 57217359265; 57203144576; 56377838800 | ycbae@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.14 | 2025-06-25 | 6 | 5 | VESICULAR GLUTAMATE TRANSPORTERS; SPINAL-CORD; IMMUNOHISTOCHEMICAL LOCALIZATION; PERIODONTAL-LIGAMENT; RAT; EXPRESSION; NEURONS; PAIN; ROOT; PROTEINS | Axons; Calcitonin; Calcitonin Gene-Related Peptide; Dental Pulp; Glutamic Acid; Humans; Neuropeptides; Parvalbumins; Substance P; Synaptosomal-Associated Protein 25; Vesicular Glutamate Transport Protein 2; calcitonin; calcitonin gene related peptide; glutamic acid; neuropeptide; parvalbumin; substance P; synaptosomal associated protein 25; vesicular glutamate transporter 2; axon; human; metabolism; tooth pulp | English | 2020 | 2020-06-30 | 10.1038/s41598-020-67804-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Post-transcriptional modulation of cytochrome P450s, Cyp6g1 and Cyp6g2, by miR-310s cluster is associated with DDT-resistant Drosophila melanogaster strain 91-R | The role of miRNAs in mediating insecticide resistance remains largely unknown, even for the model species Drosophila melanogaster. Building on prior research, this study used microinjection of synthetic miR-310s mimics into DDT-resistant 91-R flies and observed both a significant transcriptional repression of computationally-predicted endogenous target P450 detoxification genes, Cyp6g1 and Cyp6g2, and also a concomitant increase in DDT susceptibility. Additionally, co-transfection of D. melanogaster S2 cells with dual luciferase reporter constructs validated predictions that miR-310s bind to target binding sites in the 3' untranslated regions (3'-UTR) of both Cyp6g1 and Cyp6g2 in vitro. Findings in the current study provide empirical evidence for a link between reduced miRNA expression and an insecticidal resistance phenotype through reduced targeted post-transcriptional suppression of transcripts encoding proteins involved in xenobiotic detoxification. These insights are important for understanding the breadth of adaptive molecular changes that have contributed to the evolution of DDT resistance in D. melanogaster. | Seong, Keon Mook; Coates, Brad S.; Pittendrigh, Barry R. | Kyungpook Natl Univ, Coll Ecol & Environm, Dept Appl Biol, Sangju, South Korea; USDA ARS, Corn Insects & Crop Genet Res Unit, Ames, IA USA; Michigan State Univ, Dept Entomol, E Lansing, MI 48824 USA | 26635871000; 7004123972; 7004045385 | kseong6@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.27 | 2025-06-25 | 13 | 12 | INSECTICIDE RESISTANCE; MICRORNA CLUSTERS; EXPRESSION; GENES; IDENTIFICATION; BIOGENESIS; TRANSMISSION; ADAPTATION; MECHANISM; EVOLUTION | 3' Untranslated Regions; Animals; Binding Sites; Cytochrome P-450 Enzyme System; DDT; Drosophila melanogaster; Drosophila Proteins; Evolution, Molecular; Gene Expression Regulation; Insecticide Resistance; Insecticides; MicroRNAs; Phenotype; Protein Processing, Post-Translational; chlorphenotane; Cyp6g1 protein, Drosophila; cytochrome P-450 6G2, Drosophila; cytochrome P450; Drosophila protein; insecticide; microRNA; MIRN310 microRNA, Drosophila; 3' untranslated region; animal; binding site; Drosophila melanogaster; drug effect; gene expression regulation; genetics; insecticide resistance; metabolism; molecular evolution; phenotype; protein processing | English | 2020 | 2020-09-01 | 10.1038/s41598-020-71250-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Prediction of the Mortality Risk in Peritoneal Dialysis Patients using Machine Learning Models: A Nation-wide Prospective Cohort in Korea | Herein, we aim to assess mortality risk prediction in peritoneal dialysis patients using machine-learning algorithms for proper prognosis prediction. A total of 1,730 peritoneal dialysis patients in the CRC for ESRD prospective cohort from 2008 to 2014 were enrolled in this study. Classification algorithms were used for prediction of N-year mortality including neural network. The survival hazard ratio was presented by machine-learning algorithms using survival statistics and was compared to conventional algorithms. A survival-tree algorithm presented the most accurate prediction model and outperformed a conventional method such as Cox regression (concordance index 0.769 vs 0.745). Among various survival decision-tree models, the modified Charlson Comorbidity index (mCCI) was selected as the best predictor of mortality. If peritoneal dialysis patients with high mCCI (>4) were aged >= 70.5 years old, the survival hazard ratio was predicted as 4.61 compared to the overall study population. Among the various algorithm using longitudinal data, the AUC value of logistic regression was augmented at 0.804. In addition, the deep neural network significantly improved performance to 0.841. We propose machine learning-based final model, mCCI and age were interrelated as notable risk factors for mortality in Korean peritoneal dialysis patients. | Noh, Junhyug; Yoo, Kyung Don; Bae, Wonho; Lee, Jong Soo; Kim, Kangil; Cho, Jang-Hee; Lee, Hajeong; Kim, Dong Ki; Lim, Chun Soo; Kang, Shin-Wook; Kim, Yong-Lim; Kim, Yon Su; Kim, Gunhee; Lee, Jung Pyo | Seoul Natl Univ, Coll Engn, Dept Comp Sci & Engn, Seoul, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Internal Med, Coll Med, Ulsan, South Korea; Univ Massachusetts, Coll Informat & Comp Sci, Amherst, MA 01003 USA; Gwangju Inst Sci & Technol GIST, Sch Elect Engn & Comp Sci, Gwangju, South Korea; Kyungpook Natl Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Boramae Med Ctr, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea | Yoo, Kyung/AAK-8096-2020; Lee, Jun-Young/N-5963-2019; Kim, Kangil/MHQ-0084-2025; Noh, Junhyug/ADR-6172-2022; Kim, Yong-Lim/AGK-3172-2022; Kim, Dong Ki/J-5389-2012; Cho, Jang-hee/ABD-3534-2020; Lee, Hyo/G-6299-2019 | 56878320200; 56603636300; 57696326500; 57201264463; 36622862500; 7403536291; 36554389800; 23479259100; 15019536200; 34768359700; 55633533600; 7410205767; 55685918100; 56028990400 | gunhee@snu.ac.kr;nephrolee@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.81 | 2025-06-25 | 24 | 30 | CHARLSON COMORBIDITY INDEX; RESIDUAL RENAL-FUNCTION; ELDERLY-PATIENTS; DISEASE PATIENTS; KIDNEY-DISEASE; HEMODIALYSIS; SURVIVAL; OUTCOMES; ESRD | Adult; Aged; Female; Humans; Machine Learning; Male; Middle Aged; Models, Biological; Mortality; Peritoneal Dialysis; Predictive Value of Tests; Prospective Studies; Republic of Korea; Risk Factors; adult; aged; biological model; clinical trial; epidemiology; female; human; machine learning; male; middle aged; mortality; peritoneal dialysis; predictive value; prospective study; risk factor; South Korea | English | 2020 | 2020-05-04 | 10.1038/s41598-020-64184-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Predictors and prognoses of Willisian collateral failure during mechanical thrombectomy | During mechanical thrombectomy in the anterior cerebral circulation, thrombus embolization resulting in Willisian collateral failure may lead to critical stroke outcomes due to a shutdown of leptomeningeal collaterals. We hypothesized that the outcomes of dynamic Willisian collateral failure (DWF), induced during mechanical thrombectomy, would be associated with grave outcomes. We evaluated this hypothesis in consecutive patients, between January 2011 and May 2016, who underwent mechanical thrombectomy for anterior circulation occlusions, with an onset-to-puncture of 24 h. Patients with initial Willisian collateral failure (IWF) were identified first, with remaining patients classified into the DWF and Willisian collateral sparing (WCS) groups. Comparative and multivariable analyses were performed to predict grave outcomes (3-month modified Rankin Scale score of 5-6). Among 567 patients, 37 were in the IWF group, 38 in the DWF group, and 492 in the WCS group. Compared to the WCS and DWF groups, the IWF group had a higher baseline National Institute of Health Stroke Scale score and lower Alberta Stroke Program Early CT Score. The prevalence of grave outcomes was similarly high in the IWF (48.6%) and DWF (47.4%) groups, but lower in the WCS group (22.0%; p<0.001). IWF and DWF were independent risk factors for a grave outcome. | Lee, Seong-Joon; Hwang, Yang-Ha; Hong, Ji Man; Choi, Jin Wook; Kang, Dong-Hun; Kim, Yong-Won; Kim, Yong-Sun; Hong, Jeong-Ho; Yoo, Joonsang; Kim, Chang-Hyun; Ovbiagele, Bruce; Demchuk, Andrew; Sohn, Sung-Il; Lee, Jin Soo | Ajou Univ, Med Ctr, Sch Med, Dept Neurol, 164 World Cup Ro, Suwon 16499, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Ajou Univ, Med Ctr, Dept Radiol, Sch Med, Suwon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Keimyung Univ, Sch Med, Brain Res Inst, Dept Neurol,Dongsan Med Ctr, 56 Dalseong Ro, Daegu 41931, South Korea; Ilsan Hosp, Natl Hlth Insurance Serv, Dept Neurol, Goyang, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Neurosurg, Daegu, South Korea; Univ Calif San Franscisco, Dept Neurol, San Francisco, CA USA; Univ Calgary, Hotchkiss Brain Inst, Dept Clin Neurosci & Radiol, Calgary, AB, Canada | Kim, Chang-Hyun/I-5166-2012; Hong, Jeong-Ho/T-8099-2018; Hong, Jeong-Ho/AAE-1002-2022; Hong, Ji Man/AAE-2686-2022; HWANG, Yang-Ha/F-3068-2013; Demchuk, Andrew/E-1103-2012 | 57218256679; 7402311308; 55729426200; 55722501000; 8977805800; 56203298200; 57095278300; 55931654800; 55261162200; 56059033400; 6603173769; 7006058585; 36479287000; 55963063300 | sungil.sohn@gmail.com;jinsoo22@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.32 | 2025-06-25 | 9 | 9 | STROKE; OCCLUSIONS; REVASCULARIZATION; RECANALIZATION; SOLITAIRE | Aged; Alberta; Brain Ischemia; Cerebral Angiography; Cerebrovascular Circulation; Collateral Circulation; Computed Tomography Angiography; Female; Humans; Male; Prognosis; Risk Factors; Stroke; Thrombectomy; aged; Alberta; brain angiography; brain circulation; brain ischemia; cerebrovascular accident; collateral circulation; computed tomographic angiography; female; human; male; pathology; physiology; procedures; prognosis; risk factor; thrombectomy | English | 2020 | 2020-11-30 | 10.1038/s41598-020-77946-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Prognostic significance of interim PET/CT response for the treatment of advanced-stage marginal zone lymphoma in the post-rituximab era | There are still controversies about the use of interim positron emission tomography/computed tomography (PET/CT) in indolent non-Hodgkin lymphoma due to the variable fluorodeoxyglucose (FDG) avidity. Therefore, this study aimed to evaluate the roles of interim PET/CT in marginal zone lymphoma (MZL), a representative indolent lymphoma. We analyzed the data of 146 MZL patients. All were treated with rituximab-containing immunochemotherapy. Interim PET/CT scan was performed after 2-3 cycles of therapy, and the response was assessed using the Deauville 5-point scales (5-PS) and a semi-quantitative assessment using the SUVmax reduction rate (Delta SUVmax). Progression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (pSUVmax did not predict the survival outcome using 59.8% of the optimal cutoff value. In the multivariate analysis, failure to achievement of grade 1-2 in interim PET/CT was significantly associated with inferior PFS (HR, 2.154; 95% CI 1.071-4.332; p=0.031). The interim PET/CT response based on the 5-PS is useful for predicting PFS of patients with MZL in the post-rituximab era. | Song, Ga-Young; Yoon, Sang Eun; Kim, Seok Jin; Kim, Jin Seok; Koh, Youngil; Moon, Joon-Ho; Oh, Sung Yong; Lee, Ho Sup; Shin, Ho-Jin; Do, Young Rok; Lee, Won Sik; Kim, Dae Sik; Park, Yong; Yhim, Ho-Young; Yang, Deok-Hwan | Chonnam Natl Univ, Hwasun Hosp, Hwasun, Jeollanam Do, South Korea; Jeonbuk Natl Univ, Med Sch, Jeonju, Jeollabukdo, South Korea; Jeonbuk Natl Univ, Res Inst Clin Med, Jeonbuk Natl Univ Hosp, Biomed Res Inst, Jeonju, South Korea; Sungkyunkwan Univ, Sch Med, Seoul, South Korea; Yonsei Univ, Coll Med, Seoul, South Korea; Seoul Natl Univ Hosp, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Hematol Oncol, Sch Med, Daegu, South Korea; Dong A Med Ctr, Busan, South Korea; Kosin Univ, Gospel Hosp, Busan, South Korea; Pusan Natl Univ Hosp, Med Res Inst, Dept Internal Med, Div Hematol Oncol, Pusan, South Korea; Keimyung Univ, Dongsan Med Ctr, Daegu, South Korea; Inje Univ, Busan Paik Hosp, Busan, South Korea; Korea Univ, Guro Hosp, Seoul, South Korea; Korea Univ, Dept Internal Med, Div Hematol Oncol, Sch Med,Anam Hosp, Seoul, South Korea; Jeonbuk Natl Univ, Dept Internal Med, Med Sch, 20 Geonji Ro, Jeonju 54907, South Korea; Chonnam Natl Univ, Hwasun Hosp, Sch Med, Dept Hematol Oncol, 322 Seoyang Ro, Hwasun Gun 58128, Jeollanam Do, South Korea | Moon, Joonho/KFQ-2464-2024; Kim, Seok-Jin/KLD-3582-2024; Kim, Dae Sik/HTT-1263-2023; KIM, JIN/I-6927-2019 | 57193027251; 57205167470; 36521373300; 55032033600; 56450114900; 56568642700; 56601510200; 57218103550; 16239868400; 8960168300; 55556573100; 55742979100; 7405373234; 35785270600; 8701758000 | yhimhy@jbnu.ac.kr;drydh1685@hotmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.18 | 2025-06-25 | 5 | 5 | POSITRON-EMISSION-TOMOGRAPHY; B-CELL LYMPHOMA; HODGKIN-LYMPHOMA; FDG-PET; INTERPRETATION CRITERIA; FOLLICULAR LYMPHOMA; 18F-FDG PET/CT; MALT LYMPHOMA; THERAPY; SCANS | Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Female; Fluorodeoxyglucose F18; Humans; Lymphoma, B-Cell, Marginal Zone; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Positron Emission Tomography Computed Tomography; Prednisone; Prognosis; Radiopharmaceuticals; Retrospective Studies; Rituximab; Survival Analysis; Vincristine; antineoplastic agent; cyclophosphamide; doxorubicin; fluorodeoxyglucose f 18; immunological antineoplastic agent; prednisone; R-CHOP protocol; R-CVP protocol; radiopharmaceutical agent; rituximab; vincristine; adult; aged; cancer staging; clinical trial; diagnostic imaging; female; human; male; marginal zone lymphoma; middle aged; mortality; multicenter study; multivariate analysis; pathology; positron emission tomography-computed tomography; prognosis; retrospective study; survival analysis; very elderly | English | 2020 | 2020-07-15 | 10.1038/s41598-020-68310-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Randomized controlled trial of medium cut-off versus high-flux dialyzers on quality of life outcomes in maintenance hemodialysis patients | Medium cut-off (MCO) dialyzers help remove larger middle molecules associated with symptoms related to the accumulation of uremic retention solutes. We investigated the effect of an MCO dialyzer on the improvement of quality of life (QOL) in maintenance hemodialysis (HD) patients. Forty-nine HD patients with high-flux dialysis were randomly assigned to either an MCO (Theranova 400, Baxter) or a high-flux (FX CorDiax 80 or 60, Fresenius Medical Care) dialyzer and completed the study. QOL was assessed at baseline and after 12 weeks of treatment using the Kidney Disease Quality of Life Short Form-36, and pruritus was assessed using a questionnaire and visual analog scale. The reduction ratios of middle molecules were also evaluated. Laboratory markers, including serum albumin, did not differ between the two groups after 12 weeks. Removals of kappa and lambda free light chains were greater for MCO dialyzer than high-flux dialyzer. The MCO group had higher scores than the high-flux group in the domains of physical functioning and physical role (75.2 +/- 20.8 vs. 59.8 +/- 30.1, P=0.042; 61.5 +/- 37.6 vs. 39.0 +/- 39.6, P=0.047, respectively), and the MCO group had lower mean scores for morning pruritus distribution and the frequency of scratching during sleep (1.29 +/- 0.46 vs. 1.64 +/- 0.64, P=0.034; 0.25 +/- 0.53 vs. 1.00 +/- 1.47, P=0.023, respectively). MCO dialyzers may improve patient-reported outcomes, particularly the physical components of QOL and uremic pruritus, in patients with high-flux dialyzers. | Lim, Jeong-Hoon; Park, Yeongwoo; Yook, Ju-Min; Choi, Soon-Youn; Jung, Hee-Yeon; Choi, Ji-Young; Park, Sun-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Cho, Jang-Hee | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea | Choi, Soon Youn/AHC-8865-2022; Lim, Jeong-Hoon/ABE-6003-2020; Cho, Jang-hee/ABD-3534-2020; Kim, Yong-Lim/AGK-3172-2022; Kim, Hyoungnae/JXN-1329-2024 | 55360244300; 57202108143; 35110084800; 15845172400; 57196396467; 7501393222; 7501831741; 8558530700; 55633533600; 7403536291 | jh-cho@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 1.54 | 2025-06-25 | 52 | 47 | ALL-CAUSE MORTALITY; UREMIC PRURITUS; ONLINE HEMODIAFILTRATION; MEMBRANE FLUX; DIALYSIS MODALITY; SURVIVAL; DISEASE; TOXINS | Aged; Biomarkers; Comorbidity; Female; Hemodiafiltration; Humans; Kidney Failure, Chronic; Male; Middle Aged; Quality of Life; Renal Dialysis; Treatment Outcome; biological marker; adverse event; aged; chronic kidney failure; comorbidity; controlled study; devices; female; hemodiafiltration; hemodialysis; human; male; metabolism; middle aged; mortality; procedures; quality of life; randomized controlled trial; treatment outcome | English | 2020 | 2020-05-08 | 10.1038/s41598-020-64622-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Rate-Loss Mitigation for a Millimeter-Wave Beamspace MIMO Lens Antenna Array System Using a Hybrid Beam Selection Scheme | The rate loss is an important issue in multiuser beamspace multiple-input-multiple-output (MIMO) millimeter-wave systems. In such systems, multicluster channel propagation results in quantization error (QE), and consequently, each active user suffers a significant rate loss. A conventional single beam selection (SBS) scheme is used in an equivalent beamspace MIMO channel to reduce the number of radio frequency (RF) chains required. However, this scheme does not properly mitigate the QE due to the limited number of channel propagation clusters per user. In addition, optimally selected RF chains are operated at the same number of precoded data streams. As a result, each active user inherently loses a huge number of data streams when utilizing the conventional SBS scheme. Therefore, we propose a novel hybrid beam selection scheme in an equivalent beamspace MIMO channel to enable multiple beam group selection and to achieve a reliable channel cluster for every active user, which directly aids in the mitigation of the QE. The numerical result is verified using computer simulations in a millimeter-wave MIMO downlink channel environment. | Sarker, Md. Abdul Latif; Kader, Md. Fazlul; Han, Dong Seog | Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Univ Chittagong, Dept Elect & Elect Engn, Chittagong 4331, Bangladesh | Kader, Dr. Md Fazlul/E-7136-2016; Han, Dong Seog/N-8949-2018 | 42262729500; 55744161600; 7403219442 | latifsarker@knu.ac.kr;f.kader@cu.ac.bd;dshan@knu.ac.kr; | IEEE SYSTEMS JOURNAL | IEEE SYST J | 1932-8184 | 1937-9234 | 14 | 3 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;OPERATIONS RESEARCH & MANAGEMENT SCIENCE;TELECOMMUNICATIONS | 2020 | 3.931 | 22.9 | 0.81 | 2025-06-25 | 14 | 14 | MIMO communication; Radio frequency; Lenses; Antenna arrays; Millimeter wave technology; Precoding; Downlink; Beamspace multiple-input-multiple-output (MIMO); lens antenna array; millimeter wave (mmWave); quantization error (QE); rate performance; single beam selection (SBS) and hybrid beam selection (HBS) scheme | ARCHITECTURE; FEEDBACK | Beamspace multiple-input-multiple-output (MIMO); lens antenna array; millimeter wave (mmWave); quantization error (QE); rate performance; single beam selection (SBS) and hybrid beam selection (HBS) scheme | Antenna arrays; Data streams; Lens antennas; MIMO systems; Multibeam antennas; Antenna array system; Channel clusters; Channel propagation; Millimeter-wave systems; Number of datum; Numerical results; Quantization errors; Radio frequency chains; Millimeter waves | English | 2020 | 2020-09 | 10.1109/jsyst.2020.2964283 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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