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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Growing Atmospheric Emissions of Sulfuryl Fluoride | The potent greenhouse gas sulfuryl fluoride (SO2F2) is increasingly used as a fumigant, replacing methyl bromide, whose structural and soil fumigation uses have been phased out under the Montreal Protocol. We use measurements on archived air samples and in situ observations from the Advanced Global Atmospheric Gases Experiment (AGAGE) and a box model of the global atmosphere to show a global increase of SO2F2 mole fraction from 0.3 +/- 0.02 to 2.5 +/- 0.08 ppt along with a global increase in emissions from 0.5 +/- 0.4 Gg yr(-1) to 2.9 +/- 0.4 Gg yr(-1) from 1978 to 2019. Based on a hybrid model incorporating bottom-up industry data and a top-down downscaling approach, we estimate the spatial distribution and trend in SO2F2 regional emissions between 2000 and 2019 and propose that the global emissions increase is driven by the growing use of SO2F2 in structural fumigation in North America and in postharvest treatment of grains and other agricultural products worldwide. | Gressent, A.; Rigby, M.; Ganesan, A. L.; Prinn, R. G.; Manning, A. J.; Muehle, J.; Salameh, P. K.; Krummel, P. B.; Fraser, P. J.; Steele, L. P.; Mitrevski, B.; Weiss, R. F.; Harth, C. M.; Wang, R. H.; O'Doherty, S.; Young, D.; Park, S.; Li, S.; Yao, B.; Reimann, S.; Vollmer, M. K.; Maione, M.; Arduini, J.; Lunder, C. R. | MIT, Ctr Global Change Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA; Univ Bristol, Sch Chem, Bristol, Avon, England; Univ Bristol, Sch Geog Sci, Bristol, Avon, England; Met Off, London, England; Univ Calif San Diego, Scripps Inst Oceanog, San Diego, CA 92103 USA; CSIRO Oceans & Atmosphere, Climate Sci Ctr, Aspendale, Vic, Australia; Kyungpook Natl Univ, Coll Nat Sci, Dept Oceanog, Daegu, South Korea; Natl Inst Meteorol Sci, Climate Res Div, Seogwipo, South Korea; China Meteorol Adm, Meteorol Observat Ctr, Beijing, Peoples R China; Empa, Swiss Fed Labs Mat Sci & Technol, Lab Air Pollut & Environm Technol, Dubendorf, Switzerland; Univ Urbino, Dept Pure & Appl Sci, Urbino, Italy; CNR, Inst Atmospher Sci & Climat, Bologna, Italy; Norwegian Inst Air Res, Kjeller, Norway | ; Muhle, Jens/GPX-3244-2022; Rigby, Matthew/A-5555-2012; Reimann, Stefan/A-2327-2009; arduini, jgor/N-2798-2016; Steele, Paul/B-3185-2009; Mitrevski, Blagoj/JAT-7514-2023; Young, Dickon/AFO-7065-2022; Fraser, Paul/D-1755-2012; Krummel, Paul/A-4293-2013; Ganesan, Anita/D-6230-2016 | 55237678900; 38762109000; 35770554200; 7005942405; 35566542600; 55917306500; 6602378882; 6602579613; 7202782061; 7102165442; 8640621400; 7404027402; 8878471400; 35345968200; 6603729725; 22837436400; 57085459500; 59631159200; 36467395000; 7006466341; 56668474200; 7005182425; 7801467546; 15835085000 | agressen@mit.edu; | JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES | J GEOPHYS RES-ATMOS | 2169-897X | 2169-8996 | 126 | 9 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2021 | 5.217 | 22.9 | 1.72 | 2025-07-30 | 17 | 20 | AGAGE; emissions; global atmosphere; SO2F2 | GASES; HALOCARBONS; LIFETIMES; CHEMISTRY; HISTORY; CHINA | AGAGE; emissions; global atmosphere; SO<sub>2</sub>F<sub>2</sub> | North America; downscaling; emission; fluoride; fumigation; greenhouse gas; in situ measurement; Montreal Protocol; spatial distribution; sulfur dioxide | English | 2021 | 2021-05-16 | 10.1029/2020jd034327 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Impact of radiation dose on complications among women with breast cancer who underwent breast reconstruction and post-mastectomy radiotherapy: A multi-institutional validation study | Purpose: Emerging data suggest that higher radiation doses in post-mastectomy radiotherapy may be associated with an increased risk of reconstruction complications. This study aimed to validate previous findings regarding the impact of radiation dose on complications among women with breast cancer using a multi-center dataset. Methods: Fifteen institutions participated, and women with breast cancer who received radiotherapy after either autologous or prosthetic breast reconstruction were included. The primary endpoint was major post-radiation therapy complications requiring re-operation for explantation, flap failure, or bleeding control. Results: In total, 314 patients were included. Radiotherapy was performed using both conventional fractionation and hypofractionation in various schedules. The range of the radiation therapy dose in Equivalent Dose in 2 Gy fractions (EQD2; alpha/beta = 3.5) varied from 43.4 to 71.0 Gy (median dose: 48.6 Gy). Boost radiation therapy was administered to 49 patients. Major post-radiation therapy complications were observed in 24 (7.6%) patients. In multivariate analysis, an increasing EQD2 per Gy (odds ratio [OR]: 1.58, 95% confidence interval [CI]: 1.26-1.98; p < 0.001), current smoking status (OR: 25.48, 95% CI: 1.56-415.65; p = 0.023), and prosthetic breast reconstruction (OR: 9.28, 95% CI: 1.84-46.70; p = 0.007) were independently associated with an increased risk of major complications. Conclusion: A dose-response relationship between radiation dose and the risk of complications was validated in this multi-center dataset. In this context, we hypothesize that the use of hypofractionated radiotherapy (40 Gy in 15 fractions) may improve breast reconstruction outcomes. Our multi-center prospective observational study (NCT03523078) is underway to further validate this hypothesis. (C) 2021 The Authors. Published by Elsevier Ltd. | Chung, Seung Yeun; Chang, Jee Suk; Shin, Kyung Hwan; Kim, Jin Ho; Park, Won; Kim, Haeyoung; Kim, Kyubo; Lee, Ik Jae; Yoon, Won Sup; Cha, Jihye; Lee, Kyu-Chan; Kim, Jin Hee; Choi, Jin Hwa; Ahn, Sung-Ja; Ha, Boram; Lee, Sun Young; Lee, Dong Soo; Lee, Jeongshim; Shin, Sei One; Lee, Sea-Won; Choi, Jinhyun; Kim, Mi Young; Kim, Yeon Joo; Im, Jung Ho; Suh, Chang-Ok; Kim, Yong Bae | Yonsei Univ, Yonsei Canc Ctr, Dept Radiat Oncol, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Ajou Univ, Dept Radiat Oncol, Sch Med, Suwon, South Korea; Seoul Natl Univ, Dept Radiat Oncol, Coll Med, 101 Daehak Ro, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Radiat Oncol, Sch Med, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Radiat Oncol, Seoul, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Radiat Oncol, Coll Med, Seoul, South Korea; Korea Univ, Med Coll, Dept Radiat Oncol, Ansan Hosp, Seoul, South Korea; Yonsei Univ, Wonju Severance Christian Hosp, Dept Radiat Oncol, Wonju Coll Med, Seoul, South Korea; Gachon Univ, Dept Radiat Oncol, Gil Med Ctr, Incheon, South Korea; Keimyung Univ, Sch Med, Dept Radiat Oncol, Dongsan Med Ctr, Daegu, South Korea; Chung Ang Univ Hosp, Dept Radiat Oncol, Seoul, South Korea; Chonnam Natl Univ, Med Sch, Hwasun Hosp, Dept Radiat Oncol, Hwasun, South Korea; Hallym Univ, Dept Radiat Oncol, Dongtan Sacred Heart Hosp, Hwasung, South Korea; Chonbuk Natl Univ Hosp, Dept Radiat Oncol, Jeonju, South Korea; Catholic Univ Korea, Dept Radiat Oncol, Uijeongbu St Marys Hosp, Uijongbu, South Korea; Inha Univ Med, Inha Univ Hosp, Dept Radiat Oncol, Incheon, South Korea; Andong Hosp, Dept Radiat Oncol, Andong Med Grp, Andong, South Korea; Catholic Univ Korea, Coll Med, Dept Radiat Oncol, Eunpyeong St Marys Hosp, Seoul, South Korea; Jeju Natl Univ Hosp, Dept Radiat Oncol, Jeju, South Korea; Kyungpook Natl Univ, Dept Radiat Oncol, Chilgok Hosp, Daegu, South Korea; Univ Ulsan, Asan Med Ctr, Dept Radiat Oncol, Coll Med, Seoul, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Radiat Oncol, Seongnam, South Korea | Kim, Hye/AAF-7609-2020; KIM, Yong/R-3111-2019; Lee, Sang Chul/KRQ-9329-2024; Lee, Jong-Young/M-6319-2013; Kim, Jae-Young/IUO-6466-2023; Lee, Jeeyun/I-7171-2015; Kim, Jae/C-5549-2012; Chang, Jee Suk/ABU-3301-2022; Kim, Hyung/J-5451-2012; CHOI, JIN HWA/LWZ-8057-2024; Shin, Kwang-Hee/C-5687-2012; Lee, Sun-Ho/AAD-6712-2022; Kim, Haeyoung/ABC-4815-2020 | 57194017690; 57191191340; 34873643900; 56723658800; 55663053400; 56007004100; 8213302900; 36786568600; 36629820700; 36150424500; 38163172100; 56441016600; 57213021227; 57211944596; 56022514500; 57203597345; 57811935400; 57211862928; 57221608343; 57388293100; 56714062800; 57204652164; 57311417000; 56096038400; 7102970921; 56080532600 | radiat@snu.ac.kr;ybkim3@yuhs.ac; | BREAST | BREAST | 0960-9776 | 1532-3080 | 56 | SCIE | OBSTETRICS & GYNECOLOGY;ONCOLOGY | 2021 | 4.254 | 22.9 | 2.22 | 2025-07-30 | 26 | 27 | Breast cancer; Breast reconstruction; Major complication; Radiation therapy | PRACTICE PATTERNS; INTERNAL MAMMARY; THERAPY; MASTECTOMY; RISK; IRRADIATION; TRENDS | Breast cancer; Breast reconstruction; Major complication; Radiation therapy | Adult; Aged; Breast Neoplasms; Dose Fractionation, Radiation; Female; Humans; Mammaplasty; Mastectomy; Middle Aged; Radiation Dosage; Radiotherapy, Adjuvant; Retrospective Studies; Treatment Outcome; antineoplastic agent; adult; aged; Article; breast cancer; breast reconstruction; cancer radiotherapy; clinical article; cohort analysis; conformal radiotherapy; female; human; hypofractionated radiotherapy; intensity modulated radiation therapy; mastectomy; multicenter study; neoadjuvant chemotherapy; observational study; postoperative complication; priority journal; prospective study; radiation dose; radiation dose fractionation; retrospective study; smoking; therapeutic equivalent dose; tomotherapy; validation study; volumetric modulated arc therapy; adjuvant radiotherapy; adverse event; breast tumor; clinical trial; mastectomy; middle aged; treatment outcome | English | 2021 | 2021-04 | 10.1016/j.breast.2021.01.003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Enzymatic characterization of a novel recombinant 1,3-α-3,6-anhydro-L-galactosidase specific for neoagarobiose hydrolysis into monosaccharides | Two GH117 family alpha-neoagarobiose hydrolases (GH117A alpha-NABH and GH117B alpha-NABH) from the freshwater agardegrading Cellvibrio sp. KY-GH-1 were expressed and purified as recombinant His-tagged proteins using an Escherichia coli expression system to compare activities. The amino acid sequence of GH117A alpha-NABH (364 amino acids, 40.9 kDa) showed 35% identity with that of GH117B alpha-NABH (392 amino acids, 44.2 kDa). GH117A alpha-NABH, but not GH117B alpha-NABH, could hydrolyze neoagarobiose (NA2) into monosaccharides 3,6-anhydro-L-galactose (L-AHG) and D-galactose. The presence of GH117A alpha-NABH homologues in all of the agar-degrading bacteria aligned suggests that GH117A alpha-NABH hydrolyzing NA2 into L-AHG and D-galactose is an essential component of the agar-degrading enzyme machinery. For GH117A alpha-NABH-catalyzed hydrolysis, NA2 was the sole substrate among various neoagaro-oligosaccharides (NA2-NA18). GH117A alpha-NABH appeared to exist as a dimer, and optimal enzymatic temperature and pH were 35 degrees C and 7.5, respectively. GH117A alpha-NABH was stable up to 35 degrees C and at pH 7.5 and unstable beyond 35 degrees C and outside pH 7.07.5. The kinetic parameters K-m,V-max, k(cat), and k(cat)/K-m for NA2 were 16.0 mM, 20.8 U/mg, 14.2 s(-1), and 8.9 x 10(2) M-1, respectively. Combined addition of 5 mM MnSO4 and 10 mM tris(2-carboxyethyl)phosphine enhanced the enzyme activity by 2.4-fold. The enzyme-mediated hydrolysis of 5.0% NA2 into monosaccharide and purification of L-AHG from hydrolysis products by Sephadex G-10 column chromatography recovered similar to 192 mg L-AHG from 400 mg NA2 (similar to 92% of the theoretical maximum yield). These results indicate that the recombinant GH117A alpha-NABH is NA2-specific and useful to produce L-AHG from NA2. | Jang, Won Young; Kwon, Mi Jung; Kim, Ki Yun; Kim, Young Ho | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioResearch Grp, Lab Immunobiol, Daegu 41566, South Korea | 56373427000; 57208820636; 57189898278; 57208312159 | ykim@knu.ac.kr; | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | APPL MICROBIOL BIOT | 0175-7598 | 1432-0614 | 105 | 11 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2021 | 5.56 | 23.0 | 0.68 | 2025-07-30 | 10 | 9 | Cellvibrio sp.; Recombinant alpha-neoagarobiose hydrolase; Dimeric form; Neoagarobiose-specific hydrolysis; Activity enhancement by Mn2+ and TCEP; 3,6-Anhydro-L-galactose | ALPHA-NEOAGAROOLIGOSACCHARIDE HYDROLASE; BETA-AGARASE; MARINE BACTERIUM; BIOCHEMICAL-CHARACTERIZATION; MOLECULAR-CLONING; PURIFICATION; OLIGOSACCHARIDES; EXPRESSION; FAMILY; PROTEINS | 3,6-Anhydro-L-galactose; Activity enhancement by Mn<sup>2+</sup> and TCEP; Cellvibrio sp; Dimeric form; Neoagarobiose-specific hydrolysis; Recombinant α-neoagarobiose hydrolase | Disaccharides; Escherichia coli; Galactosidases; Glycoside Hydrolases; Hydrolysis; Monosaccharides; Cellvibrio; Escherichia coli; Algae; Amino acids; Biodegradation; Column chromatography; Dimers; Enzyme activity; Escherichia coli; Glucose; Ion exchange; Machinery; Manganese compounds; Oligosaccharides; Phosphorus compounds; Polysaccharides; Purification; Recombinant proteins; Sulfur compounds; 3,6 anhydro galactose; bacterial polysaccharide; galactose; gh117a alpha neoagarobiose hydrolase; gh117b alpha neoagarobiose hydrolase; monosaccharide; neoagarobiose; recombinant enzyme; sephadex; tris(2 carboxyethyl)phosphine; unclassified drug; disaccharide; galactosidase; glycosidase; neoagarobiose; Amino acid sequence; Degrading bacteria; Enzyme-mediated hydrolysis; Escherichia coli expression systems; His-tagged proteins; Hydrolysis products; Neoagaro-oligosaccharides; Tris(2 carboxyethyl)phosphine; amino acid; chemical compound; detection method; enzyme; enzyme activity; hydrolysis; monosaccharide; purification; self purification; temperature effect; amino acid sequence; Article; bacterial strain; Cellvibrio; column chromatography; controlled study; enzymatic degradation; enzyme activity; enzyme analysis; enzyme purification; Escherichia coli; gene expression system; hydrolysis; nonhuman; protein expression; Escherichia coli; genetics; hydrolysis; Hydrolysis | English | 2021 | 2021-06 | 10.1007/s00253-021-11341-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Hamburger-type weighted shifts: Jumping flatness and Aluthge transforms | In- this paper, we introduce a new kind of flatness, namely "jumping flatness," of a Hamburger-type weighted shift; we characterize jumping flatness of a nonsubnormal Hamburger-type weighted shift W-alpha and obtain the expression of the associated Hamburger moment measure. Also we discuss a relationship between jumping flatness and subnormality of the Aluthge transform (W) over tilde (alpha). Precisely, we show that if W-alpha is a nonsubnormal Hamburger-type weighted shift, then W-alpha has jumping flatness if and only if there exist positive real numbers phi, phi, rho, p, and q such that mu = phi delta(-p) + phi delta(0) + rho delta(q) (or mu = phi delta(-p) +rho delta(q)) and (W) over tilde (alpha). is subnormal, where delta(x) is the usual Dirac measure. (C) 2020 Elsevier Inc. All rights reserved. | Exner, George R.; Jin, Joo Young; Jung, Il Bong; Lee, Ji Eun | Bucknell Univ, Dept Math, Lewisburg, PA 17837 USA; Kyungpook Natl Univ, Dept Math, Daegu 702701, South Korea; Sejong Univ, Dept Math & Stat, Seoul 143747, South Korea | Lee, Ji Eun/AAP-1295-2020 | 7004560697; 56535730500; 7102964485; 59125168700 | exner@bucknell.edu;pss9611@knu.ac.kr;ibjung@knu.ac.kr;jieunlee7@sejong.ac.kr; | JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS | J MATH ANAL APPL | 0022-247X | 1096-0813 | 494 | 1 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2021 | 1.417 | 23.0 | 0.3 | 2025-07-30 | 2 | 2 | Weighted shift; Hamburger moment measure; Hamburger-type; Aluthge transform; Jumping flatness | Aluthge transform; Hamburger moment measure; Hamburger-type; Jumping flatness; Weighted shift | English | 2021 | 2021-02-01 | 10.1016/j.jmaa.2020.124592 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Photoacoustic tomography with line detector: Exact inversion formula | As a novel and promising technology in medical imaging, Photoacoustic Tomography (PAT) is based on the generation of acoustic waves inside an object of interest by stimulating electromagnetic waves. This acoustic wave is measured outside the object and converted into a 3-dimensional image. Various shapes of detectors are suggested because of some limitations of the classic detector. Here we study PAT with a linear detector. We define some operator as the transform assigning to a given function f the integral of the solution of the wave equation over the detector line with the initial function f. We provide many properties of this wave operator including the inversion formulas and stability estimates under two different geometric settings. (C) 2021 Elsevier Inc. All rights reserved. | Kim, Juyeon; Moon, Sunghwan; Hristova, Yulia | Kyungpook Natl Univ, Coll Nat Sci, Dept Math, Daegu 41566, South Korea; Univ Michigan, Dept Math & Stat, Dearborn, MI 48128 USA | 57222359278; 56063426100; 25624736700 | sunghwan.moon@knu.ac.kr; | JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS | J MATH ANAL APPL | 0022-247X | 1096-0813 | 500 | 2 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2021 | 1.417 | 23.0 | 0.3 | 2025-07-30 | 3 | 2 | Photoacoustic; Tomography; Wave equation; Reconstruction; Fourier slice theorem | ALGORITHMS; PROJECTION | Fourier slice theorem; Photoacoustic; Reconstruction; Tomography; Wave equation | English | 2021 | 2021-08-15 | 10.1016/j.jmaa.2021.125119 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A Glycosylated Prodrug to Attenuate Neuroinflammation and Improve Cognitive Deficits in Alzheimer's Disease Transgenic Mice | We report a prodrug, Glu-DAPPD, to overcome the shortcomings of an anti-neuroinflammatory molecule, N,N'-diacetyl-p-phenylenediamine (DAPPD), in biological applicability for potential therapeutic applications. We suspect that Glu-DAPPD can release DAPPD through endogenous enzymatic bioconversion. Consequently, Glu-DAPPD exhibits in vivo efficacies in alleviating neuroinflammation, reducing amyloid-beta aggregate accumulation, and improving cognitive function in Alzheimer's disease transgenic mice. Our studies demonstrate that the prodrug approach is suitable and effective toward developing drug candidates against neurodegeneration. | Kim, Mingeun; Park, Min Hee; Nam, Geewoo; Lee, Misun; Kang, Juhye; Song, Im-Sook; Choi, Min-Koo; Jin, Hee Kyung; Bae, Jae-Sung; Lim, Mi Hee | Korea Adv Inst Sci & Technol KAIST, Dept Chem, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, KNU Alzheimers Dis Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, BK21 Plus Kyungpook Natl Univ Biomed Convergence, Dept Biomed Sci, Daegu 41944, South Korea; Ulsan Natl Inst Sci & Technol UNIST, Dept Chem, Ulsan 44919, South Korea; Pohang Univ Sci & Technol, Tech Support Ctr, Off Res Affairs, Pohang 37673, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Dankook Univ, Coll Pharm, Cheonan 31116, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Lab Anim Med, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Alzheimers Dis Res Inst, Daegu 41566, South Korea | Lim, Mi/D-1913-2018; Kim, Young/T-8521-2019; Bae, Jae-sung/AAM-8663-2021; Lim, Mi Hee/D-1913-2018 | 57195974442; 55807755700; 57194472444; 57193331811; 37083924000; 7201564500; 8695781400; 8088145800; 35209510400; 7201472961 | hkjin@knu.ac.kr;isbae@knu.ac.kr;miheelim@kaist.ac.kr;jsbae@knu.ac.kr; | MOLECULAR PHARMACEUTICS | MOL PHARMACEUT | 1543-8384 | 1543-8392 | 18 | 1 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2021 | 5.364 | 23.1 | 0.86 | 2025-07-30 | 10 | 10 | Alzheimer's disease; prodrug; anti-neuroinflammation; microglial function; amyloid-beta | ARYLAMINE N-ACETYLTRANSFERASES; MESENCHYMAL STEM-CELLS; MICROGLIAL DYSFUNCTION; BETA-GLUCOSIDASES; SPECIFICITY; TARGET; METABOLISM; CLEARANCE; MECHANISM; PROTEIN | Alzheimer's disease; amyloid-β; anti-neuroinflammation; microglial function; prodrug | Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line, Tumor; Cognition; Cognitive Dysfunction; Disease Models, Animal; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neurons; Phenylenediamines; Prodrugs; amyloid beta protein; glycosylated n,n' diacetyl 4 phenylenediamine; n,n' diacetyl 4 phenylenediamine; phenylenediamine derivative; prodrug; unclassified drug; amyloid beta protein; amyloid precursor protein; N,N'-diacetyl-p-phenylenediamine; phenylenediamine derivative; prodrug; Alzheimer disease; animal cell; animal experiment; animal model; animal tissue; area under the curve; Article; biotransformation; blood brain barrier; cognition; cognitive defect; controlled study; drug design; drug half life; drug stability; drug synthesis; experimental neuroinflammation; glycosylation; in vivo study; maximum concentration; mean residence time; morning dosage; mouse; neuroprotection; nonhuman; priority journal; protein aggregation; time to maximum plasma concentration; Alzheimer disease; animal; C57BL mouse; cognitive defect; disease model; drug effect; human; inflammation; male; metabolism; microglia; nerve cell; transgenic mouse; tumor cell line | English | 2021 | 2021-01-04 | 10.1021/acs.molpharmaceut.0c00677 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A Novel DUF569 Gene Is a Positive Regulator of the Drought Stress Response in Arabidopsis | In the last two decades, global environmental change has increased abiotic stress on plants and severely affected crops. For example, drought stress is a serious abiotic stress that rapidly and substantially alters the morphological, physiological, and molecular responses of plants. In Arabidopsis, several drought-responsive genes have been identified; however, the underlying molecular mechanism of drought tolerance in plants remains largely unclear. Here, we report that the "domain of unknown function" novel gene DUF569 (AT1G69890) positively regulates drought stress in Arabidopsis. The Arabidopsis loss-of-function mutant atduf569 showed significant sensitivity to drought stress, i.e., severe wilting at the rosette-leaf stage after water was withheld for 3 days. Importantly, the mutant plant did not recover after rewatering, unlike wild-type (WT) plants. In addition, atduf569 plants showed significantly lower abscisic acid accumulation under optimal and drought-stress conditions, as well as significantly higher electrolyte leakage when compared with WT Col-0 plants. Spectrophotometric analyses also indicated a significantly lower accumulation of polyphenols, flavonoids, carotenoids, and chlorophylls in atduf569 mutant plants. Overall, our results suggest that novel DUF569 is a positive regulator of the response to drought in Arabidopsis. | Nabi, Rizwana Begum Syed; Tayade, Rupesh; Hussain, Adil; Adhikari, Arjun; Lee, In-Jung; Loake, Gary J.; Yun, Byung-Wook | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Rural Dev Adm, Natl Inst Crop Sci, Dept Southern Area Crop Sci, Miryang 50424, South Korea; Abdul Wali Khan Univ, Dept Agr, Mardan 230200, Pakistan; Univ Edinburgh, Sch Biol Sci, Inst Mol Plant Sci, Kings Bldg, Edinburgh EH9 3JH, Midlothian, Scotland | Tayade, Rupesh/AAM-9652-2021; Lee, In-Jung/GLS-0432-2022; Hussain, Adil/K-6016-2018; Hussain, Dr. Adil/K-6016-2018; Adhikari, Arjun/AAV-6297-2021; Adhikari, Arjun/JCO-3306-2023 | 57200232212; 57191753234; 41961162600; 57195601415; 16425830900; 35583673400; 8245123600 | rizwananabi@korea.kr;rupesh.tayade@gmail.com;adilhussain@awkum.edu.pk;xteriousarjun7@gmail.com;ijlee@knu.ac.kr;G.Loake@ed.ac.uk;bwyun@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 22 | 10 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 6.208 | 23.1 | 1.33 | 2025-07-30 | 22 | 23 | Arabidopsis; drought; DUF569; antioxidant activity | SPHINGOMONAS SP LK11; NITRIC-OXIDE; OXIDATIVE STRESS; SIGNAL-TRANSDUCTION; NITRATE REDUCTASE; ACID BIOSYNTHESIS; STOMATAL CLOSURE; SALINITY STRESS; S-NITROSYLATION; ABIOTIC STRESS | Antioxidant activity; Arabidopsis; Drought; DUF569 | Abscisic Acid; Acclimatization; Antioxidants; Arabidopsis; Arabidopsis Proteins; Droughts; Gene Expression Regulation, Plant; Gene Knockout Techniques; Genes, Plant; Lipid Peroxidation; Loss of Function Mutation; Phenotype; Plants, Genetically Modified; Stress, Physiological; abscisic acid; amino acid; carotenoid; catalase; catechol oxidase; chlorophyll; electrolyte; flavonoid; nitrate reductase; peroxidase; plant protein; polyphenol; superoxide dismutase; antioxidant; Arabidopsis protein; antioxidant activity; Arabidopsis; Article; controlled study; drought stress; lipid peroxidation; loss of function mutation; nonhuman; oxidation reduction reaction; phenotype; plant gene; plant leaf; spectrofluorometry; wild type; wilting; acclimatization; Arabidopsis; drought; gene expression regulation; gene knockout; genetics; metabolism; physiological stress; physiology; transgenic plant | English | 2021 | 2021-05 | 10.3390/ijms22105316 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Activation of Nrf2/HO-1 by Peptide YD1 Attenuates Inflammatory Symptoms through Suppression of TLR4/MYyD88/NF-κB Signaling Cascade | In this study, we investigate the immunomodulatory effects of a novel antimicrobial peptide, YD1, isolated from Kimchi, in both in vitro and in vivo models. We establish that YD1 exerts its anti-inflammatory effects via up-regulation of the Nrf2 pathway, resulting in the production of HO-1, which suppresses activation of the NF-kappa B pathway, including the subsequent proinflammatory cytokines IL-1 beta, IL-6, and TNF-alpha. We also found that YD1 robustly suppresses nitric oxide (NO) and prostaglandin E2 (PGE(2)) production by down-regulating the expression of the upstream genes, iNOS and COX-2, acting as a strong antioxidant. Collectively, YD1 exhibits vigorous anti-inflammatory and antioxidant activity, presenting it as an interesting potential therapeutic agent. | Rahman, Md Saifur; Alam, Md Badrul; Kim, Young Kyun; Madina, Mst Hur; Fliss, Ismail; Lee, Sang Han; Yoo, Jin Cheol | Chosun Univ, Dept Pharm, Coll Pharm, Gwangju 501759, South Korea; Laval Univ, Dept Food Sci, Fac Agr & Food Sci, Quebec City, PQ G1V 0A6, Canada; Kyungpook Natl Univ, Dept Food Sci & Biotechnol, Daegu 702701, South Korea; Laval Univ, Dept Phytol, Fac Agr & Food Sci, Quebec City, PQ G1V 0A6, Canada | ; RAHMAN, MD SAIFUR/ABG-5140-2021; Alam, Md Badrul/AFL-7668-2022; Lee, Seung Eun/ABG-1607-2021 | 57192805985; 56706777100; 57193333331; 57203279223; 7004209857; 57221453703; 7402295852 | md-saifur.rahman.1@ulaval.ca;mbalam@knu.ac.kr;arirangkyk1114@naver.com;mosammad-hur.madina.1@ulaval.ca;ismail.fliss@fsaa.ulaval.ca;sang@knu.ac.kr;jcyu@chosun.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 22 | 10 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 6.208 | 23.1 | 1.62 | 2025-07-30 | 25 | 26 | anti-inflammation; YD1; peptide drug; NF-kappa B; RAW 264.7; TLR-4; MyD88; AKT | NF-KAPPA-B; ANTIOXIDANT ACTIVITIES; OXIDATIVE STRESS; MACROPHAGES; LIPOPOLYSACCHARIDE; RESPONSES; TLR4; MAPK; AMYLOLIQUEFACIENS; EXPRESSION | AKT; Anti-inflammation; MyD88; NF-κB; Peptide drug; RAW 264.7; TLR-4; YD1 | Animals; Anti-Inflammatory Agents; Cytokines; Edema; Gene Expression Regulation; Heme Oxygenase-1; Inflammation; Lipopolysaccharides; Membrane Proteins; Mice; Myeloid Differentiation Factor 88; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Pore Forming Cytotoxic Proteins; Toll-Like Receptor 4; antiinflammatory agent; antioxidant; cyclooxygenase 2; heme oxygenase 1; I kappa B kinase alpha; immunoglobulin enhancer binding protein; indometacin; inducible nitric oxide synthase; interleukin 10; interleukin 1beta; interleukin 6; myeloid differentiation factor 88; n (2 cyclohexyloxy 4 nitrophenyl)methanesulfonamide; nitric oxide; polypeptide antibiotic agent; prostaglandin E2; reactive oxygen metabolite; toll like receptor 4; transcription factor Nrf2; tumor necrosis factor; unclassified drug; YD1 peptide; antiinflammatory agent; cytokine; heme oxygenase 1; Hmox1 protein, mouse; immunoglobulin enhancer binding protein; lipopolysaccharide; membrane protein; Myd88 protein, mouse; myeloid differentiation factor 88; Nfe2l2 protein, mouse; nitric oxide; pore forming cytotoxic protein; Tlr4 protein, mouse; toll like receptor 4; transcription factor Nrf2; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; Article; Bacillus amyloliquefaciens; carrageenan-induced inflammation; cell viability; controlled study; cytokine production; down regulation; drug purification; drug synthesis; gene expression; immunomodulation; in vitro study; in vivo study; kimchi; mouse; nonhuman; Nrf2 signaling; paw edema; protein expression; protein phosphorylation; reverse transcription polymerase chain reaction; signal transduction; transcription initiation; upregulation; Western blotting; animal; drug effect; edema; gene expression regulation; genetics; inflammation; metabolism; pathology | English | 2021 | 2021-05 | 10.3390/ijms22105161 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Alleviation of Memory Deficit by Bergenin via the Regulation of Reelin and Nrf-2/NF-κB Pathway in Transgenic Mouse Model | The present study aims to determine the neuroprotective effect of Bergenin against spatial memory deficit associated with neurodegeneration. Preliminarily, the protective effect of Bergenin was observed against H2O2-induced oxidative stress in HT-22 and PC-12 cells. Further studies were performed in 5xFAD Tg mouse model by administering Bergenin (1, 30 and 60 mg/kg; orally), whereas Bergenin (60 mg/kg) significantly attenuated the memory deficit observed in the Y-maze and Morris water maze (MWM) test. Fourier transform-infrared (FT-IR) spectroscopy displayed restoration of lipids, proteins and their derivatives compared to the 5xFAD Tg mice group. The differential scanning calorimeter (DSC) suggested an absence of amyloid beta (A beta) aggregation in Bergenin-treated mice. The immunohistochemistry (IHC) analysis suggested the neuroprotective effect of Bergenin by increasing Reelin signaling (Reelin/Dab-1) and attenuated A beta (1-42) aggregation in hippocampal regions of mouse brains. Furthermore, IHC and western blot results suggested antioxidant (Keap-1/Nrf-2/HO-1), anti-inflammatory (TLR-4/NF-kB) and anti-apoptotic (Bcl-2/Bax/Caspase-3) effect of Bergenin. Moreover, a decrease in Annexin V/PI-stained hippocampal cells suggested its effect against neurodegeneration. The histopathological changes were reversed significantly by Bergenin. In addition, a remarkable increase in antioxidant level with suppression of pro-inflammatory cytokines, oxidative stress and nitric oxide production were observed in specific regions of the mouse brains. | Shal, Bushra; Khan, Adnan; Khan, Ashraf Ullah; Ullah, Rahim; Ali, Gowhar; Ul Islam, Salman; ul Haq, Ihsan; Ali, Hussain; Seo, Eun-Kyoung; Khan, Salman | Quaid I Azam Univ, Fac Biol Sci, Dept Pharm, Pharmacol Sci Res Lab, Islamabad 45320, Pakistan; Univ Peshawar, Dept Pharm, Peshawar 25120, Pakistan; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Daegu 41566, South Korea; Quaid I Azam Univ, Fac Biol Sci, Dept Pharm, Islamabad 45320, Pakistan; Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea | ; Ali, Gowhar/ISS-9183-2023; Khan, Salman/F-4588-2016; Haq, Ihsan/A-6754-2015; khan, shahan/M-6985-2017 | 57202263896; 57205082415; 57200756218; 57210856959; 57308874700; 56985186700; 55597767500; 56003879200; 7005953758; 54393307500 | bushra.shal@gmail.com;adkhan165sbbu@gmail.com;ashrafwazir6@gmail.com;Rphrahimullah@gmail.com;gowhar_ali@uop.edu.pk;dr_ssulman@yahoo.com;ihsn99@yahoo.com;h.ali@qau.edu.pk;yuny@ewha.ac.kr;skhan@qau.edu.pk; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 22 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 6.208 | 23.1 | 2.58 | 2025-07-30 | 38 | 37 | memory loss; Alzheimer's disease; Bergenin; Reelin signaling; oxidative stress; neurodegeneration | INFLAMMATORY PAIN MODELS; AMYLOID-BETA-PEPTIDE; RAT-BRAIN TISSUE; NF-KAPPA-B; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; ANTIOXIDANT STATUS; EXPRESSION; MICE; SUPPRESSION | Alzheimer’s disease; Bergenin; Memory loss; Neurode-generation; Oxidative stress; Reelin signaling | Animals; Antioxidants; Benzopyrans; Biomarkers; Cell Adhesion Molecules, Neuronal; Cell Line; Cytokines; Disease Models, Animal; Extracellular Matrix Proteins; Hydrogen Bonding; Inflammation Mediators; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Models, Molecular; Molecular Structure; Motor Activity; Nerve Tissue Proteins; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Serine Endopeptidases; Signal Transduction; Structure-Activity Relationship; Treatment Outcome; amyloid beta protein; amyloid beta protein[1-42]; bergenin; caspase 3; catalase; glutathione; glutathione transferase; heme oxygenase 1; hydrogen peroxide; immunoglobulin enhancer binding protein; kelch like ECH associated protein 1; lipid; lipocortin 5; malonaldehyde; myeloperoxidase; nitric oxide; nitrite; nucleic acid; phospholipid; protein; protein Bax; protein bcl 2; reelin; superoxide dismutase; transcription factor Nrf2; tumor necrosis factor; antioxidant; autacoid; benzopyran derivative; bergenin; biological marker; cytokine; immunoglobulin enhancer binding protein; nerve cell adhesion molecule; nerve protein; neuroprotective agent; Nfe2l2 protein, mouse; reelin protein; scleroprotein; serine proteinase; transcription factor Nrf2; amnesia; amyloid plaque; animal cell; animal experiment; animal model; animal tissue; anxiety; apoptosis; Article; brain tissue; cell viability; chemical structure; controlled study; cytokine production; differential scanning calorimetry; female; Fourier transform infrared spectroscopy; hippocampus; histopathology; immunohistochemistry; locomotion; male; maze test; molecular docking; Morris water maze test; mouse; nerve degeneration; nervous system inflammation; neuroprotection; nonhuman; oxidative stress; protein aggregation; signal transduction; spatial memory; transgenic mouse; Western blotting; animal; cell line; chemistry; disease model; drug effect; hydrogen bond; memory disorder; metabolism; molecular model; motor activity; structure activity relation; treatment outcome | English | 2021 | 2021-06 | 10.3390/ijms22126603 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Ampelopsin Confers Endurance and Rehabilitation Mechanisms in Glycine max cv. Sowonkong under Multiple Abiotic Stresses | The present investigation aims to perceive the effect of exogenous ampelopsin treatment on salinity and heavy metal damaged soybean seedlings (Glycine max L.) in terms of physiochemical and molecular responses. Screening of numerous ampelopsin concentrations (0, 0.1, 1, 5, 10 and 25 mu M) on soybean seedling growth indicated that the 1 mu M concentration displayed an increase in agronomic traits. The study also determined how ampelopsin application could recover salinity and heavy metal damaged plants. Soybean seedlings were irrigated with water, 1.5% NaCl or 3 mM chosen heavy metals for 12 days. Our results showed that the application of ampelopsin raised survival of the 45-day old salinity and heavy metal stressed soybean plants. The ampelopsin treated plants sustained high chlorophyll, protein, amino acid, fatty acid, salicylic acid, sugar, antioxidant activities and proline contents, and displayed low hydrogen peroxide, lipid metabolism, and abscisic acid contents under unfavorable status. A gene expression survey revealed that ampelopsin application led to the improved expression of GmNAC109, GmFDL19, GmFAD3, GmAPX, GmWRKY12, GmWRKY142, and GmSAP16 genes, and reduced the expression of the GmERF75 gene. This study suggests irrigation with ampelopsin can alleviate plant damage and improve plant yield under stress conditions, especially those including salinity and heavy metals. | Kazerooni, Elham Ahmed; Al-Sadi, Abdullah Mohammed; Kim, Il-Doo; Imran, Muhammad; Lee, In-Jung | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Sultan Qaboos Univ, Dept Plant Sci, Coll Agr & Marine Sci, POB 34, Al Khoud 123, Oman | ; Lee, In-Jung/GLS-0432-2022; Imran, Muhammad/AFL-6590-2022; Al-Sadi, Abdullah/D-6766-2012 | 57191375873; 8602920100; 56269995600; 58282433800; 16425830900 | elham.ghasemi.k@gmail.com;alsadi@squ.edu.om;ildookim@hanmail.net;m.imran02@yahoo.com;ijlee@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 22 | 20 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 6.208 | 23.1 | 0.37 | 2025-07-30 | 6 | 6 | soybean; salinity; heavy metal; ampelopsin; antioxidant enzymes; amino acids; fatty acid | WRKY TRANSCRIPTION FACTORS; WHEAT TRITICUM-AESTIVUM; GENOME-WIDE ANALYSIS; SAP GENE FAMILY; SALT STRESS; FATTY-ACID; ARABIDOPSIS-THALIANA; SALICYLIC-ACID; TRANSGENIC TOBACCO; OSMOTIC-ADJUSTMENT | Amino acids; Ampelopsin; Antioxidant enzymes; Fatty acid; Heavy metal; Salinity; Soybean | Abscisic Acid; Antioxidants; Carotenoids; Chlorophyll; Flavonoids; Metals, Heavy; Plant Roots; Seedlings; Sodium Chloride; Soybean Proteins; Soybeans; Stress, Physiological; Transcription Factors; abscisic acid; amino acid; ampelopsin; antioxidant; ascorbate peroxidase; basic leucine zipper transcription factor; cadmium; chlorophyll a; chlorophyll b; fatty acid; fatty acid desaturase 3; heavy metal; hydrogen peroxide; lipid; proline; protein; reactive oxygen metabolite; salicylic acid; sodium chloride; stress associated protein 16; sugar; transcription factor; transcription factor nac; transcription factor wrky; unclassified drug; water; ampelopsin; antioxidant; carotenoid; chlorophyll; flavonoid; heavy metal; sodium chloride; soybean protein; transcription factor; abiotic stress; antioxidant activity; Article; chlorophyll content; controlled study; dry weight; endurance; fresh weight; gene expression; lipid metabolism; nonhuman; plant damage; plant gene; plant growth; plant leaf; plant root; plant yield; rehabilitation care; salinity; soybean; chemistry; drug effect; genetics; growth, development and aging; metabolism; physiological stress; seedling; soybean | English | 2021 | 2021-10 | 10.3390/ijms222010943 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | ATLAS trial of adjuvant axitinib in patients with renal cell carcinoma: subgroup analyses with focus on axitinib dosing and racial groups | Background: The ATLAS trial, investigating adjuvant axitinib versus placebo in renal cell carcinoma (RCC), was stopped for futility at a preplanned interim analysis. We report subgroup outcome analyses by ethnicity, time on treatment, dose modification and toxicity. Patients and methods: Patient demographics, baseline characteristics, treatment duration and exposure and safety were analysed for Asian versus non-Asian patients treated with axitinib versus placebo. Disease-free survival (DFS) was analysed by ethnicity, treatment duration (>= 1 versus 1 year versus = 2 versus <2 AEs within 6 months of initiating axitinib: HR 0.885 (95% CI 0.419-1.869); P = 0.7488. Conclusions: Asian versus non-Asian subgroup analysis revealed differences in AE experience and drug exposure. There were no DFS differences based on ethnicity or treatment duration, but axitinib dose reduction led to longer DFS. | Quinn, D., I; Ng, C. F.; Grande, E.; Kwon, T. G.; Linke, R.; Lee, J-L; Rosbrook, B.; Thakur, M. N.; Eto, M.; Gross-Goupil, M. | USC, Keck Sch Med, Div Oncol, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA; Chinese Univ Hong Kong, Dept Surg, Hong Kong, Peoples R China; MD Anderson Canc Ctr, Dept Med Oncol, Madrid, Spain; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; SFJ Pharmaceut, Pleasanton, CA USA; Univ Ulsan, Asian Med Ctr, Dept Med Oncol, Coll Med, Seoul, South Korea; Pfizer Oncol, New York, NY USA; Pfizer, Sandwich, Kent, England; Kyushu Univ, Dept Urol, Fukuoka, Fukuoka, Japan; Ctr Hosp Univ Bordeaux, Dept Med Oncol, Bordeaux, France | Lee, Jae Lyun/AGI-4843-2022; Ng, Chi-Fai/E-5134-2011 | 7101809555; 56026053700; 16554800300; 15073765400; 57195837864; 7601475983; 56371452700; 57223150727; 7203042247; 6603659740 | diquinn@med.usc.edu; | ESMO OPEN | ESMO OPEN | 2059-7029 | 6 | 3 | SCIE | ONCOLOGY | 2021 | 6.883 | 23.1 | 0.34 | 2025-07-30 | 8 | 7 | adjuvant; Asian; ATLAS trial; axitinib; disease-free survival; renal cell carcinoma | HIGH-RISK; SUNITINIB; SORAFENIB; THERAPY; PLACEBO | adjuvant; Asian; ATLAS trial; axitinib; disease-free survival; renal cell carcinoma | Axitinib; Carcinoma, Renal Cell; Disease-Free Survival; Humans; Kidney Neoplasms; Progression-Free Survival; axitinib; placebo; axitinib; adjuvant therapy; adult; aged; ancestry group; arthralgia; Article; Asian; asthenia; backache; Chinese; controlled study; decreased appetite; diarrhea; disease free survival; dizziness; double blind procedure; drug dose escalation; drug dose reduction; dysphonia; ethnicity; fatigue; female; headache; high risk population; human; hypertension; hypothyroidism; Japanese (people); Korean (people); major clinical study; male; nausea; overall survival; phase 3 clinical trial; proteinuria; randomized controlled trial; rash; renal cell carcinoma; rhinopharyngitis; stomatitis; treatment duration; kidney tumor | English | 2021 | 2021-06 | 10.1016/j.esmoop.2021.100105 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Beneficial Effects of Soybean-Derived Bioactive Peptides | Peptides present in foods are involved in nutritional functions by supplying amino acids; sensory functions related to taste or solubility, emulsification, etc.; and bioregulatory functions in various physiological activities. In particular, peptides have a wide range of physiological functions, including as anticancer agents and in lowering blood pressure and serum cholesterol levels, enhancing immunity, and promoting calcium absorption. Soy protein can be partially hydrolyzed enzymatically to physiologically active soy (or soybean) peptides (SPs), which not only exert physiological functions but also help amino acid absorption in the body and reduce bitterness by hydrolyzing hydrophobic amino acids from the C- or N-terminus of soy proteins. They also possess significant gel-forming, emulsifying, and foaming abilities. SPs are expected to be able to prevent and treat atherosclerosis by inhibiting the reabsorption of bile acids in the digestive system, thereby reducing blood cholesterol, low-density lipoprotein, and fat levels. In addition, soy contains blood pressure-lowering peptides that inhibit angiotensin-I converting enzyme activity and antithrombotic peptides that inhibit platelet aggregation, as well as anticancer, antioxidative, antimicrobial, immunoregulatory, opiate-like, hypocholesterolemic, and antihypertensive activities. In animal models, neuroprotective and cognitive capacity as well as cardiovascular activity have been reported. SPs also inhibit chronic kidney disease and tumor cell growth by regulating the expression of genes associated with apoptosis, inflammation, cell cycle arrest, invasion, and metastasis. Recently, various functions of soybeans, including their physiologically active functions, have been applied to health-oriented foods, functional foods, pharmaceuticals, and cosmetics. This review introduces some current results on the role of bioactive peptides found in soybeans related to health functions. | Kim, Il-Sup; Yang, Woong-Suk; Kim, Cheorl-Ho | Kyungpook Natl Univ, Adv Bioresource Res Ctr, Daegu 41566, South Korea; Nodaji Co Ltd, Pohang 37927, Gyeongsangbuk D, South Korea; SungKyunKwan Univ, Dept Biol Sci, Mol & Cellular Glycobiol Unit, Seoul 16419, Gyunggi Do, South Korea; Samsung Adv Inst Hlth Sci & Technol, Seoul 16419, Gyunggi Do, South Korea | ; Kim, Cheorl-Ho/T-6753-2019 | 55477678200; 57069270500; 7409877266 | 92kis@hanmail.net;yangws91@naver.com;chkimbio@skku.edu; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 22 | 16 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 6.208 | 23.1 | 2.05 | 2025-07-30 | 88 | 94 | soybean; bioactive peptide; positive effect; human health | ENZYME INHIBITORY PEPTIDES; REDUCE SERUM-CHOLESTEROL; CONVERTING-ENZYME; BETA-CONGLYCININ; SOY PROTEIN; IN-VITRO; ANTIOXIDANT PROPERTIES; GASTROINTESTINAL DIGESTION; IMMUNOSTIMULATING PEPTIDE; HEPG2 CELLS | Bioactive peptide; Human health; Positive effect; Soybean | Animals; Humans; Peptides; Phytochemicals; Soybean Proteins; Soybeans; lipid; oligopeptide; peptide; probiotic agent; soybean protein; peptide; phytochemical; soybean protein; antidiabetic activity; antiinflammatory activity; antimicrobial activity; antiobesity activity; antiviral activity; blood pressure; cancer cell; cancer inhibition; cardiovascular system; cell proliferation; chronic kidney failure; cognitive defect; disease exacerbation; drug effect; economic aspect; human; immunoregulation; intestine flora; lipid metabolism; modulation; neuroprotection; nonhuman; Review; skin protection; soybean; ultraviolet radiation; animal; chemistry; soybean | English | 2021 | 2021-08 | 10.3390/ijms22168570 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship | Tea is particularly rich in polyphenols, including catechins and theaflavins, thearubigins, flavonols, and phenolic acids, which are believed to contribute to the health benefits of tea. The health-promoting effects of tea polyphenols are believed to be related to their cellular defensive properties. This review is intended to briefly summarize the relationship between the chemical structures of tea polyphenols and their biological activities. Tea polyphenols appear as direct antioxidants by scavenging reactive oxygen/nitrogen species; chelating transition metals; and inhibiting lipid, protein, and DNA oxidations. They also act directly by suppressing "pro-oxidant" enzymes, inducing endogenous antioxidants, and cooperating with vitamins. Moreover, tea polyphenols regulate cellular signaling transduction pathways, importantly contributing to the prevention of chronic diseases and the promotion of physiological functions. Apparently, the features in the chemical structures of tea polyphenols are closely associated with their antioxidant potentials. | Truong, Van-Long; Jeong, Woo-Sik | Kyungpook Natl Univ, Food & Bioind Res Inst, Sch Food Sci & Biotechnol, Coll Agr & Life Sci, Daegu 41566, South Korea | Jeong, Woo-Sik/AAN-6885-2020 | 55925363400; 10440750200 | truonglongpro@gmail.com;wsjeong@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 22 | 17 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 6.208 | 23.1 | 4.72 | 2025-07-30 | 92 | 95 | cellular antioxidant defense; polyphenols; green tea; black tea; structure-activity relationship | NITRIC-OXIDE SYNTHASE; OXIDATIVE DNA-DAMAGE; RADICAL INITIATED PEROXIDATION; ACTIVATED PROTEIN-KINASES; STRESS-INDUCED APOPTOSIS; SENCAR MOUSE SKIN; NF-KAPPA-B; GREEN-TEA; BLACK TEA; LIPID-PEROXIDATION | Black tea; Cellular antioxidant defense; Green tea; Polyphenols; Structure-activity relationship | Animals; Antioxidants; Flavonoids; Humans; Protective Agents; Signal Transduction; Structure-Activity Relationship; Tea; DNA; immunoglobulin enhancer binding protein; lipid; polyphenol; protein; STAT protein; transcription factor AP 1; transition element; vitamin; antioxidant; flavonoid; protective agent; antioxidant activity; Article; chelation; chemical analysis; defense mechanism; enzyme regulation; human; lipid peroxidation; nonhuman; oxidation; signal transduction; structure activity relation; tea; animal; chemistry; drug effect; metabolism; structure activity relation; tea | English | 2021 | 2021-09 | 10.3390/ijms22179109 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | CK2 Down-Regulation Increases the Expression of Senescence-Associated Secretory Phenotype Factors through NF-κB Activation | Senescent cells secrete pro-inflammatory factors, and a hallmark feature of senescence is senescence-associated secretory phenotype (SASP). The aim of this study is to investigate the protein kinase CK2 (CK2) effects on SASP factors expression in cellular senescence and organism aging. Here CK2 down-regulation induced the expression of SASP factors, including interleukin (IL)-1 beta, IL-6, and matrix metalloproteinase (MMP) 3, through the activation of nuclear factor-kappa B (NF-kappa B) signaling in MCF-7 and HCT116 cells. CK2 down-regulation-mediated SIRT1 inactivation promoted the degradation of inhibitors of NF-kappa B (I kappa B) by activating the AKT-I kappa B kinase (IKK) axis and increased the acetylation of lysine 310 on RelA/p65, an important site for the activity of NF-kappa B. kin-10 (the ortholog of CK2 beta) knockdown increased zmp-1, -2, and -3 (the orthologs of MMP) expression in nematodes, but AKT inhibitor triciribine and SIRT activator resveratrol significantly abrogated the increased expression of these genes. Finally, antisense inhibitors of miR-186, miR-216b, miR-337-3p, and miR-760 suppressed CK2 alpha down-regulation, activation of the AKT-IKK-NF-kappa B axis, RelA/p65 acetylation, and expression of SASP genes in cells treated with lipopolysaccharide. Therefore, this study indicated that CK2 down-regulation induces the expression of SASP factors through NF-kappa B activation, which is mediated by both activation of the SIRT1-AKT-IKK axis and RelA/p65 acetylation, suggesting that the mixture of the four miRNA inhibitors can be used as anti-inflammatory agents. | Song, Junbin; Bae, Young-Seuk | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea | ; Bae, Youn-Sang/G-8073-2012 | 57216972249; 8230659600 | junbin9292@naver.com;ysbae@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 22 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 6.208 | 23.1 | 1.03 | 2025-07-30 | 19 | 18 | SASP factors; NF-kappa B; SIRT1; AKT; protein kinase CK2; miRNA; anti-inflammatory agent | AKT; Anti-inflammatory agent; MiRNA; NF-κB; Protein kinase CK2; SASP factors; SIRT1 | Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Casein Kinase II; Cell Line, Tumor; Cellular Senescence; Down-Regulation; Gene Expression Regulation; Humans; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Matrix Metalloproteinase 3; Metalloendopeptidases; MicroRNAs; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Resveratrol; Ribonucleosides; RNA Interference; Signal Transduction; Sirtuin 1; Transcription Factor RelA; antiinflammatory agent; casein kinase II; I kappa B; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 6; lipopolysaccharide; lysine; microRNA; microrna 186 inhibitor; microrna 216b inhibitor; microrna 337 3p inhibitor; microrna 760 inhibitor; microrna inhibitor; resveratrol; sirtuin 1; stromelysin; synaptotagmin I; transcription factor RelA; triciribine; unclassified drug; Caenorhabditis elegans protein; casein kinase II; CSNK2A1 protein, human; IL1B protein, human; IL6 protein, human; interleukin 1beta; interleukin 6; lipopolysaccharide; metalloproteinase; microRNA; MIRN186 microRNA, human; MIRN216 microRNA, human; Mirn337 microRNA, human; MIRN760 microRNA, human; MMP3 protein, human; NF-kappa B kinase; protein kinase B; protein serine threonine kinase; RELA protein, human; resveratrol; ribonucleoside; SIRT1 protein, human; sirtuin 1; stromelysin; transcription factor RelA; Article; cell aging; controlled study; down regulation; enzyme activity; gene silencing; HCT 116 cell line; human; human cell; in vitro study; inflammation; MCF-7 cell line; nematode; nonhuman; phenotype; protein acetylation; protein degradation; protein expression; signal transduction; animal; Caenorhabditis elegans; cell aging; drug effect; gene expression regulation; genetics; metabolism; RNA interference; tumor cell line | English | 2021 | 2021-01 | 10.3390/ijms22010406 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Clinical Outcomes and Response Predictors of Vedolizumab Induction Treatment for Korean Patients With Inflammatory Bowel Diseases Who Failed Anti-TNF Therapy: A KASID Prospective Multicenter Cohort Study | Background: We investigated the real-life effectiveness and safety of vedolizumab (VDZ) induction therapy among Korean patients with Crohn disease (CD) or ulcerative colitis (UC) for whom anti-tumor necrosis factor therapy previously failed. Methods: Adult patients who started VDZ induction therapy at 16 centers were prospectively enrolled in the Korean VDZ nationwide registry. The coprimary outcomes were clinical remission, defined as a Crohn's Disease Activity Index score <150 points and a partial Mayo score <= 2 points with a combined rectal bleeding and stool frequency subscore <= 1 point at week 14 and endoscopic remission defined as a Mayo endoscopic subscore <= 1 point. We also analyzed predictors of clinical remission. Results: Between August 2017 and November 2019, a total of 158 patients (80 with CD and 78 with UC) received VDZ induction therapy. Clinical remission rates among patients with CD and patients with UC were 44.1% and 44.0%, respectively. Among patients with UC, the endoscopic remission rate was 32.4%. Clinical response and remission rates showed increasing trends during induction therapy. Multivariable analysis revealed that clinical response at week 6 was the only predictor of clinical remission at week 14 for both patients with CD and patients with UC. Among patients who experienced 1 or more adverse events (n = 71; 44.9%), disease exacerbation (n = 28; 17.7%) was the most common adverse event. Conclusions: Among Korean patients with CD or UC for whom anti-tumor necrosis factor therapy failed, VDZ induction therapy was effective and safe. The early clinical response was associated with clinical remission after VDZ induction therapy. | Kim, Jeongseok; Yoon, Hyuk; Kim, Nayoung; Lee, Kang-Moon; Jung, Sung-Ae; Choi, Chang Hwan; Kim, Eun Soo; Jung, Yunho; Eun, Chang Soo; Kim, Tae Oh; Kang, Sang-Bum; Kim, You Sun; Seo, Geom-Seog; Lee, Chang Kyun; Im, Jong Pil; Park, Soo Jung; Park, Dong Il; Ye, Byong Duk | Keimyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Asan Med Ctr, Dept Biostat & Clin Epidemiol, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, St Vincents Hosp, Seoul, South Korea; Ewha Womans Univ, Dept Internal Med, Sch Med, Seoul, South Korea; Chung Ang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Daegu, South Korea; Soonchunhyang Univ, Dept Med, Div Gastroenterol, Coll Med, Cheonan, South Korea; Hanyang Univ, Dept Internal Med, Guri Hosp, Guri, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Coll Med, Busan, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Div Gastroenterol,Daejeon St Marys Hosp, Daejeon, South Korea; Inje Univ, Seoul Paik Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Wonkwang Univ, Dept Internal Med, Sch Med, Iksan, South Korea; Kyung Hee Univ, Ctr Crohns & Colitis, Dept Gastroenterol, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Liver Res Inst, Coll Med, Seoul, South Korea; Yonsei Univ, Severance Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Yonsei Univ, Severance Hosp, Inst Gastroenterol, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Gastroenterol,Sch Med, 29 Saemunan Ro, Seoul 03181, South Korea; Univ Ulsan, Asan Med Ctr, Dept Gastroenterol, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Univ Ulsan, Asan Med Ctr, Inflammatory Bowel Dis Ctr, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea | Kim, Nayoung/J-5387-2012; Yoon, Hyuk/AAT-4978-2020; Lee, Chang/AAI-1012-2020; Kim, You Sun/B-2881-2015; Kwak, Sang Gyu/AAG-4341-2021; Ye, Byong/AAF-4955-2020; Kim, Sun/C-2026-2011; Kim, Hyung/J-5451-2012 | 55636277000; 34881293100; 57218663203; 35196099500; 7403676915; 55741566200; 57203086704; 54789008200; 7004074626; 57189056554; 8837205700; 56565885500; 7006501197; 26434331200; 8108755200; 56042287100; 56524839700; 14069472300 | diksmc.park@samsung.com;bdye@amc.seoul.kr; | INFLAMMATORY BOWEL DISEASES | INFLAMM BOWEL DIS | 1078-0998 | 1536-4844 | 27 | 12 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2021 | 7.29 | 23.1 | 0.98 | 2025-07-30 | 0 | 12 | vedolizumab; Crohn disease; ulcerative colitis; Korea | HOSPITAL-BASED COHORT; LONG-TERM OUTCOMES; CROHNS-DISEASE; ULCERATIVE-COLITIS; INFLIXIMAB TREATMENT; MAINTENANCE THERAPY; TEMPORAL-CHANGE; REMISSION; EFFICACY; BIOLOGICS | Crohn disease; Korea; Ulcerative colitis; Vedolizumab | Adult; Antibodies, Monoclonal, Humanized; Colitis, Ulcerative; Crohn Disease; Gastrointestinal Agents; Humans; Prospective Studies; Remission Induction; Republic of Korea; Retrospective Studies; Treatment Outcome; Tumor Necrosis Factor Inhibitors; gastrointestinal agent; monoclonal antibody; tumor necrosis factor inhibitor; vedolizumab; adult; clinical trial; Crohn disease; human; multicenter study; prospective study; remission; retrospective study; South Korea; treatment outcome; ulcerative colitis | English | 2021 | 2021-12 | 10.1093/ibd/izaa361 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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