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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Effects of a herbal formulation, KGC3P, and its individual component, nepetin, on coal fly dust-induced airway inflammation | Coal fly dust (CFD)-induced asthma model is used as an ambient particulate matter model of serious pulmonary damage. We aimed to evaluate the effects of a combination of ginseng and Salvia plebeia R. Br extract (KGC-03-PS; KG3P) and its individual components (hispidulin, nepetin and rosmarinic acid) in a CFD-induced mouse model of airway inflammation (asthma). We also evaluated signal transduction by KG3P and its individual components in the alveolar macrophage cell line, MH-S cells. In vitro, KG3P and its individual components inhibited nitric oxide production and expression of pro-inflammatory mediators and cytokines (iNOS, COX-2, IL-1 beta, IL- 6 and TNF-alpha) through the NF-kappa B and MAPK pathways in coal fly ash (CFA)-induced inflammation in MH-S cells. Moreover, in the CFD-induced asthma model in mice, KG3P and its predominant individual component, nepetin, inhibited Asymmetric Dimethyl arginine (ADMA) and Symmetric Dimethyl arginine (SDMA) in serum, and decreased the histopathologic score in the lungs. A significant reduction in the neutrophils and immune cells in BALF and lung tissue was demonstrated, with significant reduction in the expression of the pro-inflammatory cytokines. Finally, IRAK-1 localization was also potently inhibited by KG3P and nepetin. Thus, KG3P extract can be considered as a potent candidate for amelioration of airway inflammation. | Saba, Evelyn; Lee, Young-sil; Yang, Won-Kyung; Lee, Yuan Yee; Kim, Minki; Woo, Su-Min; Kim, KilSoo; Kwon, Young-Sam; Kim, Tae-Hwan; Kwak, Dongmi; Park, Yang-Chun; Shin, Han Jae; Han, Chang Kyun; Oh, Jae-Wook; Lee, Young Cheol; Kang, Hyung-Sik; Rhee, Man Hee; Kim, Seung-Hyung | Kyungpook Natl Univ, Dept Vet Med, Coll Vet Med, Lab Physiol & Cell Signalling, Daegu 41566, South Korea; Korea Inst Oriental Med, Herbal Med Res Div, 1672 Yuseong Daero, Dajeon 34054, South Korea; Daejeon Univ, Div Resp Syst, Dept Internal Med, Coll Korean Med, Daejeon, South Korea; KT&G Res Inst, Daejeon 34128, South Korea; KGC Res Inst, Daejeon 34128, South Korea; Daejeon Univ, Inst Tradit Med & Biosci, Daejeon 34520, South Korea; Konkuk Univ, Dept Stem Cell & Regenerat Biotechnol, Seoul 05029, South Korea; Sangji Univ, Dept Herbol, Coll Korean Med, 83 Sangjidae Gil, Wonju 26339, Gangwon Do, South Korea; Chonnam Natl Univ, Sch Biol Sci & Technol, Gwangju 500757, South Korea | Yuan Yee, Lee/ABH-8956-2022; Saba, Evelyn/JLN-1878-2023; Rhee, Man/O-5705-2016; Kim, Tae-Hwan/M-3962-2017; Oh, Jae-Wook/D-3597-2011; Kim, Seung-Hyung/AAA-4707-2020 | 56721112000; 57195254246; 55595700900; 57203798815; 57199747297; 57211332136; 35272034300; 7403459426; 57202984578; 7007148758; 7405369965; 57196450077; 57190975167; 34875481900; 57216173735; 26659594000; 57211035357; 54383305300 | rheemh@knu.ac.kr;sksh518@dju.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.81 | 2025-06-25 | 28 | 28 | SALVIA-PLEBEIA R.BR.; EPITHELIAL-CELLS; MURINE MODEL; TNF-ALPHA; CYTOKINES; POLLUTION; MACROPHAGES; EXPRESSION; RELEASE; GINSENG | Animals; Arginine; Asthma; Bronchoalveolar Lavage Fluid; Coal; Coal Ash; Cytokines; Disease Models, Animal; Flavones; Herbal Medicine; Lung; Mice; Signal Transduction; arginine; coal; cytokine; dimethylarginine; eupafolin; flavone derivative; adverse event; animal; asthma; bronchoalveolar lavage fluid; disease model; drug effect; fly ash; herbal medicine; immunology; lung; metabolism; mouse; pathology; signal transduction | English | 2020 | 2020-08-20 | 10.1038/s41598-020-68965-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Efficacy of a chitosan tampon in the loop electrosurgical excision procedure: A prospective randomized controlled study | It has been reported that chitosan has a hemostatic effect and an antibiotic activity. This study aimed to evaluate the efficacy and feasibility of using a chitosan tampon (Hemoblock-Tampon) in preventing hemorrhage and enhancing wound healing after the loop electrosurgical excision procedure (LEEP).This single-blind, prospective, randomized study included 62 consecutive patients who underwent LEEP for cervical intraepithelial neoplasia. A chitosan tampon (31 patients; treatment group), or a general tampon (31 patients; control group) was applied to the uterine cervix immediately after LEEP. One patient in the treatment group declined to participate in this study. Thus, 30 patients in the treatment group and 31 patients in the control group completed this study. For objective analysis of hemorrhage in the postoperative 2 weeks, the amounts of bleeding were checked daily with a pictorial blood assessment chart. We evaluated vaginal discharge, abdominal pain, and impairment in daily living during the postoperative 2 weeks using 5 visual analogue scale questionnaires.The bleeding count was significantly lower in the treatment group than in the control group (21.37 +/- 16.86 vs. 40.52 +/- 16.55, p = 0.0014). The sum of the scores of the 5 questionnaires was significantly lower in the treatment group than in the control group (6.53 +/- 2.84 vs. 8.59 +/- 2.88, p = 0.0079). The incidence of vaginal discharge was significantly lower in the treatment group than in the control group (20.0% vs. 48.4%, p = 0.0207). According to logistic regression, only the use of chitosan tampon reduced the risk of moderate to severe vaginal bleeding 2 weeks after surgery (Odd ratio, 0.213; 95% confidence interval, 0.06-0.76; p = 0.0172). Complete healing of the uterine cervix occurred in 86.7% of patients in the treatment group and in 61.3% of patients in the control group at 4 weeks after surgery (p = 0.0255).The use of chitosan tampons can reduce hemorrhage, vaginal discharge, abdominal pain, and impairment of daily living after LEEP. Moreover, chitosan tampon may help enhance wound healing. | Chong, Gun Oh; Lee, Yoon Hee; Jeon, Se Young; Yang, Hee-Young; An, Sang-Hyun | Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Obstet & Gynecol, Chilgok Hosp, Daegu 41404, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 41061, South Korea | 23099068000; 37088851700; 57216296837; 20836594900; 57102583100 | gochong@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.32 | 2025-06-25 | 12 | 13 | CERVICAL INTRAEPITHELIAL NEOPLASIA; TRANSFORMATION ZONE LLETZ; PLATELET-ADHESION; HEMORRHAGE; MANAGEMENT; GAUZE | Adult; Blood Coagulation; Chitosan; Electrosurgery; Female; Hemorrhage; Hemostatics; Humans; Middle Aged; Prospective Studies; Quality of Life; Uterus; chitosan; hemostatic agent; adult; adverse event; bleeding; blood clotting; controlled study; drug effect; electrosurgery; female; human; middle aged; procedures; prospective study; quality of life; randomized controlled trial; surgery; uterus | English | 2020 | 2020-04-07 | 10.1038/s41598-020-62965-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation | Serum cardiac troponin I (cTnI) is often elevated in patients with ischemic stroke, and is associated with their prognosis. Since cTnI is also closely related to atrial fibrillation (AF), cTnI may be a sensitive prognostic indicator in patients with AF-related stroke. This study aimed to evaluate the association between serum cTnI and early neurological deterioration (END) in patients with AF-related stroke. We included consecutive AF-related stroke patients between 2013 and 2015. END was defined as an increase >= 2 in the total NIHSS score or >= 1 in the motor NIHSS score within the first 72 h of admission. A total of 1,133 patients with AF-related stroke were evaluated. In multivariable analysis, cTnI [adjusted odds ratio (aOR)=1.16, 95% confidence interval (CI) 1.00-1.34; P=0.047] remained significant after adjusting for confounders. Initial NIHSS score (aOR=1.03, 95% CI 1.00-1.06; P=0.043) was also positively associated with END; meanwhile, the use of anticoagulants was negatively associated in both vitamin K antagonists (aOR=0.35, 95% CI 0.23-0.54; P<0.001) and new oral anticoagulants (aOR=0.41, 95% CI 0.19-0.89; P=0.024). In conclusion, higher serum cTnI was associated with END in patients with AF-related stroke. | Nam, Ki-Woong; Kim, Chi Kyung; Yu, Sungwook; Chung, Jong-Won; Bang, Oh Young; Kim, Gyeong-Moon; Jung, Jin-Man; Song, Tae-Jin; Kim, Yong-Jae; Kim, Bum Joon; Heo, Sung Hyuk; Park, Kwang-Yeol; Kim, Jeong-Min; Park, Jong-Ho; Choi, Jay Chol; Park, Man-Seok; Kim, Joon-Tae; Choi, Kang-Ho; Ha Hwang, Yang; Seo, Woo-Keun; Oh, Kyungmi | Seoul Natl Univ, Dept Neurol, Coll Med, Seoul, South Korea; Korea Univ, Guro Hosp, Coll Med, Dept Neurol, 148 Gurodong Ro, Seoul 08308, South Korea; Korea Univ, Anam Hosp, Coll Med, Dept Neurol, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, 81 Irwon Ro, Seoul 06351, South Korea; Korea Univ, Ansan Hosp, Coll Med, Dept Neurol, Ansan, South Korea; Ewha Womans Univ, Sch Med, Dept Neurol, Seoul, South Korea; Catholic Univ Korea, Dept Neurol, Seoul, South Korea; Kyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea; Chung Ang Univ, Chung Ang Univ Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Hanyang Univ, Myongji Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Jeju Natl Univ, Dept Neurol, Jeju, South Korea; Chonnam Natl Univ Hosp, Dept Neurol, Chungnam, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Neurol, Hwasun, South Korea; Kyungpook Natl Univ Hosp, Dept Neurol, Daegu, South Korea | kim, jong-eun/B-3550-2017; Kim, Chi/AAR-9819-2020; Heo, Sung/P-3529-2019; choi, jo/O-5940-2014; Kim, Jinkwon/AAR-6729-2021; Kim, Yong-Jae/JQW-5758-2023; Jung, Jin-Man/LJL-8037-2024; Choi, Kangho/HKV-1503-2023 | 57189377536; 56701057800; 56144716300; 55553751200; 7006620221; 35237139600; 15755814800; 55507164200; 55865497600; 57214661365; 18835720200; 36060099300; 7601375827; 55716977200; 7501392645; 7404490852; 23667663000; 36491173100; 7402311308; 22981667600; 16048029600 | mcastenosis@gmail.com;okyungmi@korea.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.41 | 2025-06-25 | 11 | 12 | CARDIAC TROPONIN; EUROPEAN ASSOCIATION; AMERICAN SOCIETY; RISK; ECHOCARDIOGRAPHY; DETERIORATION; OUTCOMES; RECOMMENDATIONS; UPDATE | Aged; Aged, 80 and over; Atrial Fibrillation; Female; Humans; Ischemic Stroke; Logistic Models; Male; Multivariate Analysis; Prognosis; Troponin I; troponin I; aged; atrial fibrillation; blood; brain ischemia; complication; female; human; male; multivariate analysis; pathology; prognosis; statistical model; very elderly | English | 2020 | 2020-07-28 | 10.1038/s41598-020-69303-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Emission of single photons in the weak coupling regime of the Jaynes Cummings model | A recently proposed variant of an unconventional photon blockade scheme is studied for a single emitter weakly coupled to a resonator mode. By controlling two weak coherent fields driving the emitter and the resonator mode, a strongly nonclassical output field is obtained, which is not only antibunched, but has vanishing higher photon number coincidences. For a given set of system parameters, the frequencies and strengths of the driving fields that yield such an output are given. | Noh, Changsuk | Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea | 23991025500 | cnoh@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.23 | 2025-06-25 | 10 | 6 | OPTICAL CAVITY; BLOCKADE; STATE | article; photon | English | 2020 | 2020-09-30 | 10.1038/s41598-020-72945-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | End-to-End Distortion Analysis of Nonorthogonal Layered Coding Over Relay-Assisted Networks | This article investigates cross-layer design of nonorthogonal layered (NOL) coding schemes over relay-assisted downlink of cellular networks that incorporates with successive refinement (SR) source code for transmission of adaptive multiresolution multimedia content. Two novel-layered relaying strategies, namely NOL compress-forward (NOL-CF) and NOL decode-forward (NOL-DF) coding, concatenated to the SR source coding scheme are outlined. The network parameters are jointly optimized, to derive optimal end-to-end system performance. Taking the expected distortion (ED) as the end-to-end system performance metric, the explicit analytical solution achieving optimal ED under the proposed NOL-CF scheme with two layers is derived. For the NOL-DF coding, the numerical analysis demonstrates the merits of the proposed scheme, which dynamically adapts the transmission to the instantaneous channel realization in the absence of channel knowledge at the source node. The superiority of the proposed layered coding over several available nonorthogonal multiple access relaying schemes is demonstrated for Gaussian channels. Also, simulation results confirm the effectiveness of the proposed relay-assisted NOL codes to improve the ED over Rayleigh fading channel. | Padidar, Payam; Ho, Pin-Han; Peng, Limei | Univ Waterloo, Dept Elect & Comp Engn, Waterloo, ON N2L 3G1, Canada; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea | 48361971300; 7402211578; 7201574271 | p2padida@uwaterloo.ca;p4ho@uwaterloo.ca;auroraplm@knu.ac.kr; | IEEE SYSTEMS JOURNAL | IEEE SYST J | 1932-8184 | 1937-9234 | 14 | 3 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;OPERATIONS RESEARCH & MANAGEMENT SCIENCE;TELECOMMUNICATIONS | 2020 | 3.931 | 22.9 | 0.14 | 2025-06-25 | 4 | 4 | Encoding; Relays; Distortion; NOMA; Fading channels; Base stations; System performance; Expected distortion (ED); nonorthogonal layered (NOL) code; relay channel; successive refinement (SR); superposition coding (SPC) | MULTIPLE-ACCESS; PERFORMANCE ANALYSIS; NOMA; SYSTEMS | Expected distortion (ED); nonorthogonal layered (NOL) code; relay channel; successive refinement (SR); superposition coding (SPC) | Codes (symbols); Fading channels; Rayleigh fading; Adaptive multi resolutions; Channel realizations; End-to-end distortion; End-to-end systems; Explicit analytical solutions; Multimedia contents; Performance metrices; Successive refinement; Network coding | English | 2020 | 2020-09 | 10.1109/jsyst.2020.2967781 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Expanded inverted repeat region with large scale inversion in the first complete plastid genome sequence of Plantago ovata | Plantago ovata (Plantaginaceae) is an economically and medicinally important species, however, least is known about its genomics and evolution. Here, we report the first complete plastome genome of P. ovata and comparison with previously published genomes of related species from Plantaginaceae. The results revealed that P. ovata plastome size was 162,116bp and that it had typical quadripartite structure containing a large single copy region of 82,084bp and small single copy region of 5,272bp. The genome has a markedly higher inverted repeat (IR) size of 37.4kb, suggesting large-scale inversion of 13.8kb within the expanded IR regions. In addition, the P. ovata plastome contains 149 different genes, including 43 tRNA, 8 rRNA, and 98 protein-coding genes. The analysis revealed 139 microsatellites, of which 71 were in the non-coding regions. Approximately 32 forward, 34 tandem, and 17 palindromic repeats were detected. The complete genome sequences, 72 shared genes, matK gene, and rbcL gene from related species generated the same phylogenetic signals, and phylogenetic analysis revealed that P. ovata formed a single clade with P. maritima and P. media. The divergence time estimation as employed in BEAST revealed that P. ovata diverged from P. maritima and P. media about 11.0 million years ago (Mya; 95% highest posterior density, 10.06-12.25 Mya). In conclusion, P. ovata had significant variation in the IR region, suggesting a more stable P. ovata plastome genome than that of other Plantaginaceae species. | Asaf, Sajjad; Khan, Abdul Latif; Lubna; Khan, Adil; Khan, Arif; Khan, Gulzar; Lee, In-Jung; Al-Harrasi, Ahmed | Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa, Oman; Abdul Wali Khan Univ Mardan, Dept Bot, Garden Campus, Khyber Pakhtunkhwa, Pakistan; Nord Univ, Fac Biosci & Aquaculture, Genom Grp, N-8049 Bodo, Norway; Carl von Ossietzky Univ Oldenburg, Inst Biol & Environm Sci, Oldenburg, Germany; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea | ; Khan, Abdul/H-5910-2011; Khan, Gulzar/K-1895-2015; Ul-Hamid, Anwar/B-7297-2015; Khan, Gulzar/GQH-8320-2022; Khan, Adil/AAC-5160-2022; Lee, In-Jung/GLS-0432-2022; khan, Arif/HMV-3165-2023; Asaf, Sajjad/ABA-3647-2021 | 56595059900; 26639372800; 57200621537; 57200917937; 57205385623; 55629278600; 16425830900; 6506093146 | latifepm78@yahoo.co.uk;ijlee@knu.ac.kr;aharrasi@unizwa.edu.om; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 1.63 | 2025-06-25 | 42 | 41 | COMPLETE CHLOROPLAST GENOME; GENE-EXPRESSION; DNA; EVOLUTION; SOFTWARE; MULTIPLE; REVEALS; NUCLEAR; INTRON; MODEL | Evolution, Molecular; Genome, Plant; Genomics; Inverted Repeat Sequences; Phylogeny; Plantago; Plastids; cytology; genetics; genomics; inverted repeat; molecular evolution; phylogeny; plant genome; Plantago; plastid | English | 2020 | 2020-03-03 | 10.1038/s41598-020-60803-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Gravistimulation effects on Oryza sativa amino acid profile, growth pattern and expression of OsPIN genes | Gravity is an important ecological factor regulating plant growth and developmental processes. Here we used various molecular and biochemical approaches to investigate artificial and normal gravistimulation's effect on the early growth stages of rice (Oryza sativa L.) by changing the orientations of Petri dishes. Rate of amino acid formation, root and shoot growth, and OsPIN expression was significantly higher under gravistimulation compared with the control. Clinostat rotation positively affected plant growth and amino acid profile. However, under normal gravity, vertical-oriented seedlings showed high amino acid levels compared with clinostat, 90 degrees -rotated, and control seedlings. Similarly, seedling growth significantly increased with 90 degrees -rotated and vertical orientations. Artificial gravity and exogenous indole-3-acetic acid induced OsPIN1 expression in the roots, root shoot junction, and shoots of clinorotated seedlings. Phenyl acetic acid induced OsPIN1 expression in the roots and root shoot junction of clinorotated seedlings but not in the shoot. The current study suggests that OsPIN1 is differentially regulated and that it might be involved in the regulation of plant growth. Conversely, OsPIN2 and OsPIN3a are gravity sensors and highly induced in the roots and root shoot junctions of vertical and 90 degrees -rotated seedlings and play an important role in stress conditions. Thus, on exposure to gravity, hormones, and UV-C radiation, these genes are highly regulated by jasmonic acid, 6-benzylaminopurine and gibberellic acid. | Farooq, Muhammad; Jan, Rahmatullah; Kim, Kyung-Min | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea | Jan, Rahmatullah/AIC-3439-2022; Kim, Kyung-Min Kim/C-7007-2014 | 57215544380; 57201981969; 34868260300 | kkm@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.23 | 2025-06-25 | 8 | 7 | POLAR-AUXIN-TRANSPORT; UV-B RADIATION; GRAVITY-REGULATED FORMATION; ARABIDOPSIS-THALIANA; ULTRAVIOLET-RADIATION; CUCUMBER SEEDLINGS; SHOOT GRAVITROPISM; OZONE DEPLETION; PLANT-GROWTH; ROOT-GROWTH | Amino Acids; Benzyl Compounds; Cyclopentanes; Gene Expression; Gene Expression Regulation, Developmental; Genes, Plant; Gibberellins; Gravitation; Indoleacetic Acids; Oryza; Oxylipins; Physical Stimulation; Plant Proteins; Plant Roots; Purines; Seedlings; amino acid; benzyl derivative; benzylaminopurine; cyclopentane derivative; gibberellic acid; gibberellin; indoleacetic acid; indoleacetic acid derivative; jasmonic acid; oxylipin; plant protein; purine derivative; drug effect; gene expression; gene expression regulation; genetics; gravity; growth, development and aging; metabolism; Oryza; physical stimulation; plant gene; plant root; seedling | English | 2020 | 2020-10-14 | 10.1038/s41598-020-74531-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Homeobox proteins are essential for fungal differentiation and secondary metabolism in Aspergillus nidulans | The homeobox domain-containing transcription factors play an important role in the growth, development, and secondary metabolism in fungi and other eukaryotes. In this study, we characterized the roles of the genes coding for homeobox-type proteins in the model organism Aspergillus nidulans. To examine their roles in A. nidulans, the deletion mutant strains for each gene coding for homeobox-type protein were generated, and their phenotypes were examined. Phenotypic analyses revealed that two homeobox proteins, HbxA and HbxB, were required for conidia production. Deletion of hbxA caused abnormal conidiophore production, decreased the number of conidia in both light and dark conditions, and decreased the size of cleistothecia structures. Overexpressing hbxA enhanced the production of asexual spores and formation of conidiophore under the liquid submerged conditions. The hbxB deletion mutant strains exhibited decreased asexual spore production but increased cleistothecia production. The absence of hbxB decreased the trehalose content in asexual spores and increased their sensitivity against thermal and oxidative stresses. The Delta hbxA strains produced more sterigmatocystin, which was decreased in the Delta hbxB strain. Overall, our results show that HbxA and HbxB play crucial roles in the differentiation and secondary metabolism of the fungus A. nidulans. | Son, Sung-Hun; Son, Ye-Eun; Cho, He-Jin; Chen, Wanping; Lee, Mi-Kyung; Kim, Lee-Han; Han, Dong-Min; Park, Hee-Soo | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Univ Gottingen, Dept Mol Microbiol & Genet, D-37077 Gottingen, Germany; Korea Res Inst Biosci & Biotechnol KRIBB, Biol Resource Ctr BRC, Jeongeup Si 34141, South Korea; Wonkwang Univ, Div Biol Sci, Iksan 54538, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea | ; Park, Hee-Soo/AAC-6422-2019 | 57214091244; 57200513491; 57214721558; 55715932300; 57221217721; 56264318500; 57208507235; 15751448400 | phsoo97@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.59 | 2025-06-25 | 22 | 20 | TRANSCRIPTION FACTOR; SEXUAL DEVELOPMENT; HOMEODOMAIN PROTEINS; ASEXUAL SPORULATION; GENE ENCODES; TREHALOSE; ACTIVATOR; BRLA; NSDD | Aspergillus nidulans; Fungal Proteins; Gene Expression Regulation, Fungal; Homeodomain Proteins; Oxidative Stress; Reproduction, Asexual; Spores, Fungal; fungal protein; homeodomain protein; asexual reproduction; Aspergillus nidulans; fungus spore; gene expression regulation; genetics; metabolism; oxidative stress; physiology | English | 2020 | 2020-04-08 | 10.1038/s41598-020-63300-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Incidence and treatment outcomes of secondary epiretinal membrane following intravitreal injection for diabetic macular edema | The purpose of this study was to investigate the incidence of secondary epiretinal membrane (ERM) after intravitreal injection and the effect of ERM on visual acuity and central macular thickness (CMT) in patients with diabetic macular edema (DME). We included 147 eyes of 95 patients over 18 years old who were diagnosed with DME from 2012 to 2016, treated with intravitreal injection, and followed-up more than 24 months. Mean CMT in the ERM group was significantly thicker than in the non-ERM group after 9, 12, 18, and 24 months. Secondary ERM developed in 9.5% of patients during follow-up. Compared to other agents, the incidence of secondary ERM was significantly higher after intravitreal injection of dexamethasone implant. Among patients in the ERM group, the mean decrease of CMT between preinjection and 2 weeks post-injection was significantly less after secondary ERM formation than before ERM formation. Secondary ERM formation was significantly associated with the number of intravitreal injections and the use of dexamethasone implant. Therefore, secondary ERM develops more frequently as the number of intravitreal injections increases and after intravitreal dexamethasone implant injection. The therapeutic effects of intravitreal injections for DME patients decrease after secondary ERM formation. | Kang, Yong Koo; Park, Han Sang; Park, Dong Ho; Shin, Jae Pil | Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu 41944, South Korea | KANG, YONG KOO/IVH-8723-2023 | 57204703736; 57208186456; 36676632900; 56517350400 | jps11@hanmail.net; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.59 | 2025-06-25 | 19 | 21 | ENDOTHELIAL GROWTH-FACTOR; POSTERIOR VITREOUS DETACHMENT; RANIBIZUMAB; RETINOPATHY; IMPLANT | Diabetic Retinopathy; Epiretinal Membrane; Female; Humans; Incidence; Intravitreal Injections; Macular Edema; Male; Middle Aged; Treatment Outcome; Visual Acuity; complication; diabetic retinopathy; epiretinal membrane; female; human; incidence; intravitreal drug administration; macular edema; male; middle aged; pathophysiology; treatment outcome; visual acuity | English | 2020 | 2020-01-17 | 10.1038/s41598-020-57509-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Isothermal crystallization kinetics of (Cu60Zr25Ti15)99.3Nb0.7 bulk metallic glass | This paper reports the crystallization kinetics of (Cu60Zr25Ti15)(99.3)Nb-0.7 bulk metallic glass under isothermal conditions. Differential scanning calorimetry (DSC) has been employed for isothermal annealing at ten different temperatures prior to the onset of crystallization (T-o) temperature. X-ray diffraction and transmission electron microscopy have been used to confirm the amorphous structure of the as cast sample. Crystallized volume fractions (x) are calculated from the exothermic peaks of DSC scans. Crystallized volume fractions (x) against time show sigmoidal type of curves as well as the curves become steeper at higher annealing temperatures. Continuous heating transformation diagram has been simulated to understand the stability of the bulk metallic glass. Crystallization kinetics parameters are calculated using Arrhenius and Johnson-Mehl-Avrami equations. Activation energy (E-a) and Avrami exponential factor (n) have exhibited strong correlation with crystallized volume fraction (x). The average activation energy for isothermal crystallization is found to be 330 +/- 30 kJ/mol by Arrhenius equation. Nucleation activation energy (E-nucleation) is found to be higher than that of growth activation energy (E-growth). The Avrami exponential factor (n) indicates about the diffusion controlled mechanism of the nucleation and three-dimensional growth. | Mandal, Soumen; Lee, Dong-Eun; Park, Taejoon | Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Architecture & Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Hanyang Univ, Dept Robot Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea | Mandal, Soumen/AAB-3917-2021 | 57214752240; 56605563300; 55717001200 | dolee@knu.ac.kr;taejoon@hanyang.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.68 | 2025-06-25 | 19 | 20 | SUPERCOOLED LIQUID REGION; THERMAL-STABILITY; NONISOTHERMAL CRYSTALLIZATION; MECHANICAL-PROPERTIES; CORROSION-RESISTANCE; FORMING ABILITY; TRANSFORMATION; NI; COMPOSITE; ALLOY | English | 2020 | 2020-06-29 | 10.1038/s41598-020-67390-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Joint Trajectory Design, Tx Power Allocation, and Rx Power Splitting for UAV-Enabled Multicasting SWIPT Systems | This article studies a joint resource allocation for an unmanned aerial vehicle (UAV) enabled simultaneous wireless information and power transfer (SWIPT) system in a multicasting scenario, where a UAV is dispatched to simultaneously send common information and wireless power to multiple users on the ground while the users decode information and harvest energy based on the power splitting (PS) receiver architecture. In this system, we aim to maximize the minimum achievable rate among all users under their harvested energy constraints by optimizing trajectory and transmit power of the UAV jointly with PS ratios of the users. To solve this challenging nonconvex problem, we first convert it into a more tractable form by exploiting the quadratic transform technique. Then, we propose an efficient iterative algorithm for the joint optimization. Numerical results show that the proposed scheme outperforms baseline schemes. | Kang, Jae-Mo; Chun, Chang-Jae | Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea; Korea Electrotechnol Res Inst, Ind Applicat Res Div, Chang Won 51543, South Korea | Chun, Changjae/AAF-2393-2019 | 56024930400; 55694574800 | jmkang@knu.ac.kr;cjchun84@gmail.com; | IEEE SYSTEMS JOURNAL | IEEE SYST J | 1932-8184 | 1937-9234 | 14 | 3 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;OPERATIONS RESEARCH & MANAGEMENT SCIENCE;TELECOMMUNICATIONS | 2020 | 3.931 | 22.9 | 1.97 | 2025-06-25 | 48 | 47 | Multicast communication; Resource management; Trajectory; Wireless communication; Optimization; Unmanned aerial vehicles; Transforms; Energy harvesting; multicasting; power allocation; power splitting (PS); simultaneous wireless information and power transfer (SWIPT); trajectory design; unmanned aerial vehicle (UAV) | COMPLETION-TIME; MINIMIZATION | Energy harvesting; multicasting; power allocation; power splitting (PS); simultaneous wireless information and power transfer (SWIPT); trajectory design; unmanned aerial vehicle (UAV) | Antennas; Constrained optimization; Energy transfer; Iterative methods; Multicasting; Unmanned aerial vehicles (UAV); Information and power transfers; Iterative algorithm; Joint optimization; Joint resource allocations; Joint trajectories; Minimum achievable rate; Numerical results; Receiver architecture; Wireless power transfer | English | 2020 | 2020-09 | 10.1109/jsyst.2020.2966534 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Light-driven complex 3D shape morphing of glassy polymers by resolving spatio-temporal stress confliction | Programmable 3D shape morphing of hot-drawn polymeric sheets has been demonstrated using photothermal local shrinkage of patterned hinges. However, the hinge designs have been limited to simple linear hinges used to generate in-plane local folding or global curvature. Herein, we report an unprecedented design strategy to realize localized curvature engineering in 3D structures employing radial hinges and stress-releasing facets on 2D polymeric sheets. The shape and height of the 3D structures are readily controlled by varying the number of radial patterns. Moreover, they are numerically predictable by finite elemental modeling simulation with consideration of the spatio-temporal stress distribution, as well as of stress competition effects. Localized curvature engineering provides programming capabilities for various designs including soft-turtle-shell, sea-shell shapes, and saddle architectures with the desired chirality. The results of local curvilinear actuation with quantifiable stress implies options to advance the applicability of self-folded architectures embodying coexisting curved and linear geometric surfaces. | Lee, Jong Hyeok; Choi, Jun-Chan; Won, Sukyoung; Lee, Jae-Won; Lee, Jae Gyeong; Kim, Hak-Rin; Wie, Jeong Jae | Inha Univ, Dept Polymer Sci & Engn, 100 Inha Ro, Incheon 22212, South Korea; Kyungpook Natl Univ, Sch Elect Engn, 80 Daehak Ro, Daegu 41566, South Korea | ; Kim, Hak-Rin/T-1897-2019; Won, Sukyoung/AAJ-2817-2020; Wie, Jeong Jae (JJ)/I-9878-2019 | 57205743003; 57033068900; 57208283996; 58377059800; 57217492620; 7410124944; 26041261000 | rineey@knu.ac.kr;wie@inha.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.36 | 2025-06-25 | 7 | 8 | SHEETS; FABRICATION; FILMS | English | 2020 | 2020-07-02 | 10.1038/s41598-020-67660-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Lipopolysaccharide administration for a mouse model of cerebellar ataxia with neuroinflammation | Most cerebellar ataxias (CAs) are incurable neurological disorders, resulting in a lack of voluntary control by inflamed or damaged cerebellum. Although CA can be either directly or indirectly related to cerebellar inflammation, there is no suitable animal model of CA with neuroinflammation. In this study, we evaluated the utility of an intracerebellar injection of lipopolysaccharide (LPS) to generate an animal model of inflammatory CA. We observed that LPS administration induced the expression of pro-inflammatory molecules following activation of glial cells. In addition, the administration of LPS resulted in apoptotic Purkinje cell death and induced abnormal locomotor activities, such as impaired motor coordination and abnormal hindlimb clasping posture. Our results suggest that intracerebellar LPS administration in experimental animals may be useful for studying the inflammatory component of CA. | Hong, Jungwan; Yoon, Dongyeong; Nam, Youngpyo; Seo, Donggun; Kim, Jong-Heon; Kim, Min Sung; Lee, Tae Yong; Kim, Kyung Suk; Ko, Pan-Woo; Lee, Ho-Won; Suk, Kyoungho; Kim, Sang Ryong | Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, BK21 Plus KNU Biomed Convergence Program, Dept Pharmacol,Brain Sci & Engn Inst, Daegu 41944, South Korea; Corestem Inc, Bioengn Inst, Seoul 13486, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu 41944, South Korea | 57196247899; 57214744587; 55143100300; 57207584467; 57203324811; 57218438989; 57205775062; 59082232900; 55543341200; 35337240700; 7005114595; 56486163800 | neuromd@knu.ac.kr;ksuk@knu.ac.kr;srk75@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.81 | 2025-06-25 | 27 | 32 | MICROGLIAL ACTIVATION; NEUROTOXICITY; DYSFUNCTION; EXPRESSION; DISEASES; INJURY | Animals; Cells, Cultured; Cerebellar Ataxia; Cerebellum; Disease Models, Animal; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Neuroglia; Purkinje Cells; lipopolysaccharide; animal; C57BL mouse; cell culture; cerebellar ataxia; cerebellum; disease model; drug effect; glia; inflammation; male; mouse; Purkinje cell | English | 2020 | 2020-08-07 | 10.1038/s41598-020-70390-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Machine learning analysis to automatically measure response time of pharyngeal swallowing reflex in videofluoroscopic swallowing study | To evaluate clinical features and determine rehabilitation strategies of dysphagia, it is crucial to measure the exact response time of the pharyngeal swallowing reflex in a videofluoroscopic swallowing study (VFSS). However, measuring the response time of the pharyngeal swallowing reflex is labor-intensive and particularly for inexperienced clinicians, it can be difficult to measure the brief instance of the pharyngeal swallowing reflex by VFSS. To accurately measure the response time of the swallowing reflex, we present a novel framework, able to detect quick events. In this study, we evaluated the usefulness of machine learning analysis of a VFSS video for automatic measurement of the response time of a swallowing reflex in a pharyngeal phase. In total, 207 pharyngeal swallowing event clips, extracted from raw VFSS videos, were annotated at the starting point and end point of the pharyngeal swallowing reflex by expert clinicians as ground-truth. To evaluate the performance and generalization ability of our model, fivefold cross-validation was performed. The average success rates of detection of the class "during the swallowing reflex" for the training and validation datasets were 98.2% and 97.5%, respectively. The average difference between the predicted detection and the ground-truth at the starting point and end point of the swallowing reflex was 0.210 and 0.056 s, respectively. Therefore, the response times during pharyngeal swallowing reflex are automatically detected by our novel framework. This framework can be a clinically useful tool for estimating the absence or delayed response time of the swallowing reflex in patients with dysphagia and improving poor inter-rater reliability of evaluation of response time of pharyngeal swallowing reflex between expert and unskilled clinicians. | Lee, Jong Taek; Park, Eunhee; Hwang, Jong-Moon; Jung, Tae-Du; Park, Donghwi | Elect & Telecommun Res Inst ETRI, Artificial Intelligence Applicat Res Sect, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ Hosp, Dept Rehabil Med, Daegu, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Phys Med & Rehabil, 877 Bangeojinsunhwando Ro, Ulsan 44033, South Korea | Park, Donghwi/GYQ-6185-2022 | 24341317500; 56107216400; 56367634000; 36622364500; 56606561400 | teeed0522@hanmail.net;bdome@hanmail.net; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 1.18 | 2025-06-25 | 37 | 41 | RELIABILITY; STROKE | Deglutition; Deglutition Disorders; Female; Fluoroscopy; Gastrointestinal Transit; Humans; Machine Learning; Male; Middle Aged; Pharynx; Reaction Time; Reflex; Reproducibility of Results; Video Recording; dysphagia; female; fluoroscopy; gastrointestinal transit; human; machine learning; male; middle aged; pathophysiology; pharynx; physiology; procedures; reaction time; reflex; reproducibility; swallowing; videorecording | English | 2020 | 2020-09-07 | 10.1038/s41598-020-71713-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Medium cut-off dialyzer improves erythropoiesis stimulating agent resistance in a hepcidin-independent manner in maintenance hemodialysis patients: results from a randomized controlled trial | The response to erythropoiesis stimulating agents (ESAs) is affected by inflammation linked to middle molecules in hemodialysis (HD) patients. We evaluated the effect of a medium cut-off (MCO) dialyzer on ESA resistance in maintenance HD patients. Forty-nine patients who underwent high-flux HD were randomly allocated to the MCO or high-flux group. The primary outcome was the changes of erythropoietin resistance index (ERI; U/kg/wk/g/dL) between baseline and 12 weeks. The MCO group showed significant decrease in the ESA dose, weight-adjusted ESA dose, and ERI compared to the high-flux group at 12 weeks (p<0.05). The generalized estimating equation models revealed significant interactions between groups and time for the ESA dose, weight-adjusted ESA dose, and ERI (p<0.05). Serum iron and transferrin saturation were higher in the MCO group at 12 weeks (p<0.05). The MCO group showed a greater reduction in TNF-alpha and lower serum TNF-alpha level at 12 weeks compared to the high-flux group (p<0.05), whereas no differences were found in the reduction ratio of hepcidin and serum levels of erythropoietin, erythroferrone, soluble transferrin receptor and hepcidin between groups. HD with MCO dialyzer improves ESA resistance over time compared to high-flux HD in maintenance HD patients. The MCO dialyzer provides superior removal of the inflammatory cytokine and thus improves iron metabolism in a hepcidin-independent manner. | Lim, Jeong-Hoon; Jeon, Yena; Yook, Ju-Min; Choi, Soon-Youn; Jung, Hee-Yeon; Choi, Ji-Young; Park, Sun-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Cho, Jang-Hee | Kyungpook Natl Univ, Sch Med, Div Nephrol, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea | Lim, Jeong-Hoon/ABE-6003-2020; Choi, Soon Youn/AHC-8865-2022; Kim, Yong-Lim/AGK-3172-2022; Cho, Jang-hee/ABD-3534-2020; Kim, Hyoungnae/JXN-1329-2024 | 55360244300; 57209909350; 35110084800; 15845172400; 57196396467; 7501393222; 7501831741; 8558530700; 55633533600; 7403536291 | jh-cho@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.72 | 2025-06-25 | 24 | 25 | C-REACTIVE PROTEIN; ONLINE HEMODIAFILTRATION; INFLAMMATION; ANEMIA; MORTALITY; ALPHA; HYPORESPONSIVENESS; CYTOKINES; THERAPY; ESRD | Aged; Anemia; C-Reactive Protein; Erythropoiesis; Erythropoietin; Female; Hematinics; Hepcidins; Humans; Inflammation; Iron; Kidney Failure, Chronic; Male; Middle Aged; Receptors, Transferrin; Renal Dialysis; Tumor Necrosis Factor-alpha; antianemic agent; C reactive protein; EPO protein, human; erythropoietin; HAMP protein, human; hepcidin; iron; transferrin receptor; tumor necrosis factor; aged; anemia; blood; chronic kidney failure; controlled study; drug effect; erythropoiesis; female; hemodialysis; human; inflammation; male; metabolism; middle aged; pathophysiology; procedures; randomized controlled trial | English | 2020 | 2020-09-29 | 10.1038/s41598-020-73124-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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