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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Allogeneic hematopoietic cell transplantation can overcome the adverse prognosis indicated by secondary-type mutations in de novo acute myeloid leukemia | Secondary-type mutations (STMs), namely SRSF2, SF3B1, U2AF1, ZRSR2, ASXL1, EZH2, BCOR, and STAG2, are more frequently detected in secondary acute myeloid leukemia (AML) than in de novo AML. Whether de novo AML with STMs should be differently managed is, however, unclear. In 394 patients diagnosed with de novo AML who had a normal karyotype, the genetic profiling via targeted deep sequencing of 45 genes revealed 59 patients carrying STMs (STM+). The STM+ group showed shorter overall survival (OS) than the STM- group (5-year OS, 15.3 vs. 31.0%) (hazard ratio [HR]: 1.975, 95% confidence interval [CI]: 1.446-2.699, p < 0.001). Among the 40 STM+ patients who achieved CR, those who received allogeneic HCT (n = 15) showed better OS (5-year OS, 40.0 vs. 12.0%) (HR: 0.423, 95% CI: 0.184-0.975, p = 0.043) and relapse-free survival (5-year, 40.0 vs. 8.0%) (HR: 0.438, 95% CI: 0.189-1.015, p = 0.054) than those who received consolidation chemotherapy only. The cumulative incidence of relapse was lower in the patients who received allogeneic HCT (5-year, 33.3 vs. 60.0%) (HR: 0.288, 95% CI: 0.111-0.746, p = 0.011), and non-relapse mortality was similar between the two groups (p = 0.935). In conclusion, STM is an independent prognostic factor for adverse outcomes in AML that can be overcome by allogeneic HCT. | Song, Ga-Young; Kim, TaeHyung; Ahn, Seo-Yeon; Jung, Sung-Hoon; Kim, Mihee; Yang, Deok-Hwan; Lee, Je-Jung; Choi, Seung Hyun; Kim, Mi Yeon; Jung, Chul Won; Jang, Jun-Ho; Kim, Hee Je; Moon, Joon Ho; Sohn, Sang Kyun; Won, Jong-Ho; Park, Seong-Kyu; Kim, Sung-Hyun; Zhang, Zhaolei; Ahn, Jae-Sook; Kim, Hyeoung-Joon; Kim, Dennis Dong Hwan | Chonnam Natl Univ, Hwasun Hosp, Hematol Oncol, Jeollanam Do, South Korea; Univ Toronto, Dept Comp Sci, Toronto, ON, Canada; Univ Toronto, Donnelly Ctr Cellular & Biomol Res, Toronto, ON, Canada; Chonnam Natl Univ, Hwasun Hosp, Genom Res Ctr Hematopoiet Dis, Jeollanam Do, South Korea; Samsung Med Ctr, Div Hematol Oncol, Seoul, South Korea; Catholic Univ Korea, Dept Hematol, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Hematol Oncol, Daegu, South Korea; Soon Chun Hyang Univ Hosp, Dept Hematol Oncol, Seoul, South Korea; Dong A Univ, Coll Med, Dept Hematol Oncol, Busan, South Korea; Univ Toronto, Dept Mol Genet, Toronto, ON, Canada; Univ Toronto, Princess Margaret Canc Ctr, Dept Med Oncol & Hematol, Toronto, ON, Canada | Won, Jongho/AAM-8322-2021; Kim, Dennis/AAH-8499-2019; Kim, Hee-Je/O-3501-2019; Kim, Tae/O-4252-2015; Lee, Jung-Hye/F-6974-2013; Lee, Sang-Jun/A-3892-2015; Park, Jung Hyun/HJA-3755-2022 | 57193027251; 55763792349; 55945078500; 55511978300; 57218694093; 8701758000; 7601478211; 57203643100; 57904806900; 56405934800; 56470133700; 7410130758; 56568642700; 13310226800; 26434081600; 57077159400; 56547959500; 57203273189; 22984055900; 7410127473; 56312200900 | f0115@chonnam.ac.kr;hjoonk@chonnam.ac.kr;dr.dennis.kim@uhn.ca; | BONE MARROW TRANSPLANTATION | BONE MARROW TRANSPL | 0268-3369 | 1476-5365 | 57 | 12 | SCIE | HEMATOLOGY;IMMUNOLOGY;ONCOLOGY;TRANSPLANTATION | 2022 | 4.8 | 21.2 | 1.83 | 2025-06-25 | 15 | 15 | CLASSIFICATION; DIAGNOSIS; THERAPY; ADULTS | Disease-Free Survival; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Mutation; Prognosis; Recurrence; acute myeloid leukemia; adult; adverse outcome; aged; allogeneic hematopoietic stem cell transplantation; Article; cancer mortality; cancer prognosis; cancer survival; controlled study; female; gene sequence; human; major clinical study; male; overall survival; recurrence free survival; relapse; survival rate; acute myeloid leukemia; disease free survival; hematopoietic stem cell transplantation; mutation; prognosis; recurrent disease | English | 2022 | 2022-12 | 10.1038/s41409-022-01817-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | Allogeneic stem cell transplantation with 3-days busulfan plus fludarabine as conditioning regimen for patients with relapsed or refractory t- and nk/t-cell lymphomas | Lee, J. H.; Yang, D. -H.; Jo, J. -C.; Lee, Y. J.; Lee, W. -S.; Choi, Y. S.; Moon, J. H.; Do, Y. R. | Dong A Univ, Coll Med, Seogu, South Korea; Chonnam Natl Univ, Hwasun Hosp, Hwasun, South Korea; Univ Ulsan, Ulsan Univ Hosp, Coll Med, Ulsan, South Korea; Inje Univ, Busan Paik Hosp, Coll Med, Busan, South Korea; Ajou Univ, Sch Med, Suwon, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Daegu, South Korea; Keimyung Univ, Dongsan Med Ctr, Sch Med, Daegu, South Korea | Jo, Jae-Cheol/CAE-9453-2022 | BONE MARROW TRANSPLANTATION | BONE MARROW TRANSPL | 0268-3369 | 1476-5365 | 57 | SUPPL 1 | SCIE | HEMATOLOGY;IMMUNOLOGY;ONCOLOGY;TRANSPLANTATION | 2022 | 4.8 | 21.2 | 0 | English | 2022 | 2022-11 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | Improvements in scintillation performance of Tl2LaCl5:5%Ce single crystals via Sr²⁺, Ba²⁺ and Ca²⁺ co-doping | High detection efficiency for X- and gamma-rays, the possibility for fast neutron detection, and other excellent scintillation performances of Tl2LaCl5 (TLC) make it a potential radiation detector for applications in space exploration, medical imaging, homeland security, radiation monitoring, and nuclear and particle physics experiments. We evaluated the luminescence and scintillation performance of pure TLC and TLC doped with 5 mol% Ce (TLC:Ce) and co-doped with 5 mol% Ce and 0.2 mol% Ba, Ca, and Sr crystals, separately (TLC:Ce,Ba, TLC:Ce,Ca and TLC:Ce,Sr). The effect of co-doping on the luminescence and scintillation performance of TLC:Ce is studied for the 1st time. The room temperature radio- and photoluminescence shows characteristic Ce3+ luminescence for the Ce-doped and co-doped TLC crystals. We found that the co-doped crystals show improvement in terms of light yield, while improvement in the energy resolution and non-proportionality is observed in TLC co-doped with Ce and Sr. | Khan, Arshad; Quoc Vuong, Phan; Daniel, D. Joseph; Kim, H. J.; Rooh, Gul; Luan, Nguyen Thanh | Najran Univ, Promising Ctr Sensors & Elect Devices PCSED, POB 1988, Najran 11001, Saudi Arabia; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Abdul Wali Khan Univ, Dept Phys, Mardan 23200, Pakistan | ; Khan, Arshad/ABB-1566-2021; Rooh, Gul/AAF-2076-2019; Kim, Hong Joo/AAE-1178-2022; Thanh Duong, Nguyen/AGY-4248-2022 | 56017063700; 57973579700; 55235066800; 59051568100; 24401665700; 57210576969 | CRYSTENGCOMM | CRYSTENGCOMM | 1466-8033 | 24 | 46 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CRYSTALLOGRAPHY | 2022 | 3.1 | 21.2 | 0.38 | 2025-06-25 | 5 | 5 | GAMMA-RAYS; EFFICIENT SCINTILLATOR; HALIDE SCINTILLATOR; X-RAY; CE3+; DEPENDENCE; DETECTORS; TL2ZRCL6 | Chlorine compounds; Doping (additives); Lanthanum compounds; Medical imaging; Neutron detectors; Neutron irradiation; Scintillation; Single crystals; Space research; Ca 2+; Ce-doped; Co-doped; Co-doping; Detection efficiency; Fast-neutron detection; Nuclear and particle physics; Radiation monitoring; Scintillation performance; Space explorations; Gamma rays | English | 2022 | 2022-11-29 | 10.1039/d2ce01124g | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Synthesis, crystal growth, structural and physicochemical properties of an organic single crystal (C11H16N2O4) for fast scintillation and NLO applications | 2-Amino-4-methyl pyridinium glutaric acid (2A4MGA) was synthesized and single crystals were grown from solution for the first time. From the single crystal X-ray diffraction (SCXRD) measurements, it was confirmed that the title compound crystallizes as a triclinic system and has a centrosymmetric nature with the space group P1. The calculated unit cell parameters are as follows: a = 7.1853(7) angstrom, b = 9.5314(9) angstrom, c = 11.0896(11) angstrom, alpha = gamma = 90 degrees, beta = 105.665(3)degrees and volume = 731.27(12) angstrom(3). The crystal structure was connected by the protonated 2-amino-4-methylpyridinium cations and the H-atoms in the carboxylic groups of the glutaric acid anions. The presence of various functional groups was studied, wherein the in-plane/out-of-plane stretching and symmetric/asymmetric vibrations were investigated through Fourier transform infrared (FT-IR) spectral analysis. From the thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) measurements, the thermal properties of the sample were investigated. The lower absorption edge was observed at 340 nm through UV-vis (ultraviolet-visible) spectral analysis, and the optical band gap was calculated to be 3.6 eV. The third-order optical susceptibility (chi((3))) of the sample was studied through the Z-scan spectra. Photoluminescence (PL) spectra for the grown crystal were recorded at room temperature and the peak emission was observed at 364 nm upon an excitation of 340 nm. The X-ray-induced emission spectrum shows a maximum peak at 364 nm. It has a fast scintillation decay time of 12 ns under gamma-ray excitation from a Cs-137 radiation source, which is comparable with that of currently available organic scintillators. The results suggest that this crystal can be used as an organic scintillator and in NLO applications. | Daniel, D. Joseph; Karuppasamy, P.; Vuong, P. Q.; Kim, H. J. | Kyungpook Natl Univ, Ctr High Energy Phys, Daegu 41566, South Korea; SSN Res Ctr, Kalavakkam 603110, Tamil Nadu, India | ; Kim, Hong Joo/AAE-1178-2022; Pichan, Karuppasamy/N-5474-2017 | 35319662800; 59942562900; 57207618553; 59051568100 | hongjoo@knu.ac.kr; | CRYSTENGCOMM | CRYSTENGCOMM | 1466-8033 | 24 | 15 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CRYSTALLOGRAPHY | 2022 | 3.1 | 21.2 | 0.46 | 2025-06-25 | 5 | 6 | NONLINEAR-OPTICAL PROPERTIES; FLUORESCENCE; COCRYSTALS; DESIGN | Crystal atomic structure; Crystal growth; Differential scanning calorimetry; Emission spectroscopy; Energy gap; Gamma rays; Ionization; Mass spectrometry; Physicochemical properties; Scintillation; Scintillation counters; Spectrum analysis; Thermogravimetric analysis; Vibration analysis; Glutaric acid; Grown from solutions; Organic scintillator; Organic single crystals; Physicochemical property; Pyridinium; Synthesised; Title compounds; Triclinic systems; X-ray diffraction measurements; Single crystals | English | 2022 | 2022-04-12 | 10.1039/d1ce01674a | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Thallium-based heavy inorganic scintillators: recent developments and future perspectives | The current development status and future perspectives of Tl-based inorganic scintillators are highlighted in this study. The thallium (Tl) ion is known to exhibit highly efficient luminescence in the widely used NaI:Tl+, CsI:Tl+, and recently discovered Cs2Cu3I5:Tl+ scintillators. Besides being an efficient luminescence center, Tl possesses high density and atomic number, so that its presence in the host material increases the density and effective atomic number of the scintillators, which provides higher efficiencies for high-energy X- and gamma-ray detection. Based on this idea, several novel efficient scintillators were reported by different research groups, which can be utilized in medical imaging, homeland security, space research, nuclear and high energy physics, rare event searches, and oil well logging. An overview of reported Tl-based scintillators and future directions for their improvements are discussed herein based on prior publications. | Kim, HongJoo; Khan, Arshad; Daniel, Joseph; Rooh, Gul; Vuong, Phan Quoc | Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Abdul Wali Khan Univ, Dept Phys, Mardan 23200, Pakistan | Kim, Hong Joo/AAE-1178-2022; Khan, Arshad/ABB-1566-2021; Rooh, Gul/AAF-2076-2019 | 59051568100; 56017063700; 36145005300; 24401665700; 57207618553 | hongjoo@knu.ac.kr; | CRYSTENGCOMM | CRYSTENGCOMM | 1466-8033 | 24 | 3 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CRYSTALLOGRAPHY | 2022 | 3.1 | 21.2 | 0.84 | 2025-06-25 | 8 | 11 | CRYSTAL-GROWTH; INTRINSIC SCINTILLATORS; EFFICIENT SCINTILLATOR; HALIDE SCINTILLATOR; FAST-NEUTRON; GAMMA-RAYS; X-RAY; CE3+; LUMINESCENCE; TL2ZRCL6 | Atoms; Cesium iodide; Global positioning system; High energy physics; Iodine compounds; Ionization; Medical imaging; Oil well logging; Scintillation; Scintillation counters; Sodium Iodide; Space research; 'current; Atomic numbers; Development status; Effective atomic number; Future perspectives; Higher efficiency; Host materials; Inorganic scintillator; Luminescence centers; Thallium ions; Gamma rays | English | 2022 | 2022-01-18 | 10.1039/d1ce01422f | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The microbial communities (bacteria, algae, zooplankton, and fungi) improved biofloc technology including the nitrogen-related material cycle in Litopenaeus vannamei farms | Microbes are essential in biofloc technology for controlling nitrogen levels in water. The composition and function of microorganisms with biofloc systems were reported; however, data on microorganisms other than bacteria, such as algae (which are essential in the nitrogen cycle) and zooplankton (which are bacterial and algal predators), remain limited. The microbial communities (including bacteria, algae, zooplankton, and fungi) were investigated in shrimp farms using biofloc technology. Using Illumina MiSeq sequencing, the V4 region of 18S rRNA and the V3-V4 region of 16S rRNA were utilized for the analysis of the eukaryotic and prokaryotic microbial communities. As a result, it was found that the biofloc in the shrimp farm consisted of 48.73%-73.04% eukaryotic organisms and 26.96%-51.27% prokaryotic organisms. In these shrimp farms, prokaryotic microbial communities had higher specie richness and diversity than eukaryotic microbial communities. However, the eukaryotic microbial communities were more abundant than their prokaryotic counterparts, while algae and zooplankton dominated them. It was discovered that the structures of the microbial communities in the shrimp farms seemed to depend on the effects of predation by zooplankton and other related organisms. The results provided the nitrogen cycle in biofloc systems by the algal and bacterial groups in microbial communities. | Yun, Hyun-Sik; Kim, Dong-Hyun; Kim, Jong-Guk; Kim, Young-Saeng; Yoon, Ho-Sung | Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci & Biotechnol, BK21 Plus KNU Creat Biores Grp, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Ulleung Do & Dok Do, Daegu, South Korea; Kyungpook Natl Univ, Adv Bioresource Res Ctr, Daegu, South Korea | Kim, Dong Hyun/LDT-2672-2024 | 57215320824; 59444469900; 35277198800; 35798433500; 7402990205 | kimjg@knu.ac.kr;kyslhh1228@hanmail.net;hsy@knu.ac.kr; | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | FRONT BIOENG BIOTECH | 2296-4185 | 10 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 5.7 | 21.2 | 1.4 | 2025-06-25 | 13 | 15 | biofloc technology; illumina MiSeq; microbial community; shrimp farm; zoo plankton | DNA EXTRACTION; GREEN-ALGAE; SHRIMP; AQUACULTURE; DIVERSITY; GROWTH; AMMONIA; PROTEIN; OSCILLATORIA; INOCULATION | biofloc technology; illumina MiSeq; microbial community; shrimp farm; zoo plankton | Bacteria; Fungi; Nitrogen; RNA; Bio-flocs technologies; Bioflocs; Eukaryotics; Illumen miseq; Illumina; Microbial communities; Nitrogen cycles; Prokaryotics; Shrimp farm; Zoo-plankton; Algae | English | 2022 | 2022-11-23 | 10.3389/fbioe.2022.883522 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | CAR T-Cell-Based gene therapy for cancers: new perspectives, challenges, and clinical developments | Chimeric antigen receptor (CAR)-T cell therapy is a progressive new pillar in immune cell therapy for cancer. It has yielded remarkable clinical responses in patients with B-cell leukemia or lymphoma. Unfortunately, many challenges remain to be addressed to overcome its ineffectiveness in the treatment of other hematological and solidtumor malignancies. The major hurdles of CAR T-cell therapy are the associated severe life-threatening toxicities such as cytokine release syndrome and limited anti-tumor efficacy. In this review, we briefly discuss cancer immunotherapy and the genetic engineering of T cells and, In detail, the current innovations in CAR T-cell strategies to improve efficacy in treating solid tumors and hematologic malignancies. Furthermore, we also discuss the current challenges in CAR T-cell therapy and new CAR T-cell-derived nanovesicle therapy. Finally, strategies to overcome the current clinical challenges associated with CAR T-cell therapy are included as well. | Jogalekar, Manasi P.; Rajendran, Ramya Lakshmi; Khan, Fatima; Dmello, Crismita; Gangadaran, Prakash; Ahn, Byeong-Cheol | Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, Daegu, South Korea; Northwestern Univ, Feinberg Sch Med, Dept Neurol Surg, Chicago, IL USA; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu, South Korea | Gangadaran, Prakash/AAV-3102-2021; Jogalekar, Manasi/AAG-6925-2020; Khan, Fatima/GQP-2552-2022; Rajendran, Ramya/AAV-6338-2021; Dmello, Crismita/ABE-3901-2022 | 57194462336; 57195318729; 57205752395; 55151400900; 54393130400; 7202791511 | prakashg@knu.ac.kr;abc2000@knu.ac.kr; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 13 | SCIE | IMMUNOLOGY | 2022 | 7.3 | 21.4 | 4.89 | 2025-06-25 | 117 | 134 | immunotherapy; gene therapy; CAR T-cell therapy; solid cancers; hematologic malignancies | CHIMERIC-ANTIGEN-RECEPTOR; CHRONIC LYMPHOCYTIC-LEUKEMIA; BRENTUXIMAB VEDOTIN SGN-35; CYTOKINE RELEASE SYNDROME; ACUTE MYELOID-LEUKEMIA; B-CELL; PHASE-I; ADOPTIVE IMMUNOTHERAPY; ANTITUMOR-ACTIVITY; EXTRACELLULAR VESICLES | CAR T-cell therapy; gene therapy; hematologic malignancies; immunotherapy; solid cancers | Genetic Therapy; Hematologic Neoplasms; Humans; Immunotherapy, Adoptive; Neoplasms; T-Lymphocytes; B cell maturation antigen; BCG vaccine; biological marker; carcinoembryonic antigen; cyclophosphamide; cytotoxic T lymphocyte antigen 4; epidermal growth factor receptor; fludarabine; gamma interferon; gelatinase A; granzyme B; immune checkpoint inhibitor; intercellular adhesion molecule 1; interleukin 15; interleukin 2; interleukin 7; ipilimumab; mesothelin; sipuleucel T; T lymphocyte receptor; tocilizumab; transcription factor FOXP3; tumor antigen; tumor necrosis factor; acute lymphoblastic leukemia; acute myeloid leukemia; anaplastic large cell lymphoma; antigen presenting cell; antineoplastic activity; B cell leukemia; B cell lymphoma; cancer immunotherapy; CD4+ T lymphocyte; CD8+ T lymphocyte; cell based gene therapy; chimeric antigen receptor T-cell immunotherapy; chronic lymphatic leukemia; colorectal carcinoma; cytokine release syndrome; dendritic cell; diffuse large B cell lymphoma; follicular lymphoma; genetic engineering; glioblastoma; hematologic malignancy; hematopoietic stem cell transplantation; Hodgkin disease; human; immune response; immunocompetent cell; immunotherapy; liver cell carcinoma; macrophage; mantle cell lymphoma; marginal zone lymphoma; metastatic melanoma; minimal residual disease; multiple myeloma; natural killer cell; NF kB signaling; nonhodgkin lymphoma; overall survival; pancreas carcinoma; progression free survival; protein synthesis; Review; T cell lymphoma; T lymphocyte; T lymphocyte activation; triple negative breast cancer; tumor growth; tumor lysis syndrome; tumor microenvironment; upregulation; adoptive immunotherapy; adverse event; gene therapy; genetics; hematologic disease; neoplasm | English | 2022 | 2022-07-22 | 10.3389/fimmu.2022.925985 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Chemical characteristics of heterogeneous lignocellulosic microfines prepared using the glycol ether-organosolv process: dissolution properties in an NaOH-urea aqueous solution | In this study, heterogeneous lignocellulosic microfines (LCMFs) with different physicochemical properties were prepared from softwood by adjusting the reaction conditions of a glycol ether-organosolv process. The dissolution properties of heterogeneous LCMFs in an NaOH-urea aqueous solution were evaluated. As the reaction time increased, the yield and residual lignin content decreased. As the amount of chemical solution used to prepare LCMFs increased, more lignin than carbohydrates were removed, but the degree of polymerization (DP) was maintained. Finally, LCMFs with different residual lignin content, DP, and crystallinity were prepared via the glycol ether-organosolv process under various conditions. It was observed that lower the lignin content of heterogeneous LCMFs, higher were their solubilities in the NaOH-urea solution. The effect of DP on solubility was not significant; however, the hemicellulose content of LCMFs had a greater effect on their solubilities in the NaOH-urea aqueous solution than the sugar composition of hemicellulose. The chemical properties of lignin present in LCMFs had no significant effect on their solubilities in the NaOH-urea aqueous solution. | Kim, Kang-Jae; Ryu, Ji-Ae; Eom, Tae-Jin | Kyungpook Natl Univ, Sch Forestry Sci & Landscape Architecture, Daegu 41566, South Korea; Kyungpook Natl Univ, Agr Sci & Technol Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Wood Sci & Technol, Daegu 41566, South Korea | Kim, Kang-Jae/K-3915-2019 | 35733947500; 57195239379; 13410809400 | jaeya0624@knu.ac.kr;jaryu@knu.ac.kr;tjeom@knu.ac.kr; | HOLZFORSCHUNG | HOLZFORSCHUNG | 0018-3830 | 1437-434X | 76 | 6 | SCIE | FORESTRY;MATERIALS SCIENCE, PAPER & WOOD | 2022 | 2.4 | 21.4 | 0.05 | 2025-06-25 | 0 | 1 | degree of polymerization; heterogeneous lignocellulosic microfines; lignin content; NaOH-urea aqueous solution; organosolv process | LIGNIN MODEL-COMPOUND; LIQUEFACTION MECHANISM; CELLULOSE; WOOD; PHENOL; PULP; TEMPERATURE; BEHAVIOR; TRENDS | degree of polymerization; heterogeneous lignocellulosic microfines; lignin content; NaOH-urea aqueous solution; organosolv process | Chemical Properties; Dissolving; Ethers; Ethylene Glycol; Lignin Content; Processes; Residual Lignin; Urea; Cellulose; Crystallinity; Dissolution; Ethers; Glycols; Lignin; Metabolism; Physicochemical properties; Polymerization; Solubility; Urea; Degrees of polymerizations; Glycol ethers; Heterogeneous lignocellulosic microfine; Lignin contents; Ligno-cellulosics; NaOH-urea aqueous solution; Organosolv; Organosolv process; Property; Residual lignins; Sodium hydroxide | English | 2022 | 2022-06-27 | 10.1515/hf-2021-0092 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effect of Salivary Exosomal miR-25-3p on Periodontitis With Insulin Resistance | Periodontitis is caused by an oral microbial dysbiosis-mediated imbalance of the local immune microenvironment, which is promoted by insulin resistance and obesity. The prevalence and severity of periodontitis is higher in patients with type 2 diabetes than in healthy individuals, possibly because of differences in immune responses. The level of glycemic control also affects the saliva profile, which may further promote periodontal disease in diabetes patients. Therefore, we compared the salivary exosomal miRNA profiles of patients with type 2 diabetes with those of healthy individuals, and we found that exosomal miR-25-3p in saliva is significantly enriched (by approximately 2-fold, p < 0.01) in obese patients with type 2 diabetes. We also identified CD69 mRNA as a miR-25-3p target that regulates both activation of gamma delta T cells and the inflammatory response. Knockdown of CD69 increased (by approximately 2-fold) interleukin-17A production of gamma delta T cells in vitro. To evaluate the role of exosomal miRNA on progression of periodontitis, we analyzed regional immune cells in both periodontal tissues and lymph nodes from mice with periodontitis. We found that diet-induced obesity increased the population of infiltrating pro-inflammatory immune cells in the gingiva and regional lymph nodes of these mice. Treatment with miR-25-3p inhibitors prevented the local in vivo inflammatory response in mice with periodontitis and diet-induced obesity. Finally, we showed that suppression of interleukin 17-mediated local inflammation by a miR-25-3p inhibitor alleviated (by approximately 34%) ligature-induced periodontal alveolar bone loss in mice. Taken together, these data suggest that exosomal miR-25-3p in saliva contributes to development and progression of diabetes-associated periodontitis. Discovery of additional miR-25-3p targets may provide critical insights into developing drugs to treat periodontitis by regulating gamma delta T cell-mediated local inflammation. | Byun, Jin-Seok; Lee, Ho Yeop; Tian, Jingwen; Moon, Ji Sun; Choi, Jaejin; Lee, Sang-Hee; Kim, Yong-Gun; Yi, Hyon-Seung | Kyungpook Natl Univ, Dept Oral Med, Sch Dent, Daegu, South Korea; Chungnam Natl Univ, Dept Med Sci, Sch Med, Daejeon, South Korea; Chungnam Natl Univ, Res Ctr Endocrine & Metab Dis, Sch Med, Daejeon, South Korea; Chungnam Natl Univ, Lab Endocrinol & Immune Syst, Sch Med, Daejeon, South Korea; Panagene Inc, Dept Res & Dev, Daejeon, South Korea; Korea Basic Sci Inst, Bioelect Microscopy Res Ctr Dong 104, Cheongju, South Korea; Kyungpook Natl Univ, Dept Periodontol, Sch Dent, Daegu, South Korea | Yi, Hyon-Seung/ABA-2729-2022 | 55430621800; 57221714890; 57218201812; 57207780661; 57420483300; 58743241400; 55622694400; 55376878100 | periokyg@knu.ac.kr;jmpbooks@cnu.ac.kr; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 12 | SCIE | IMMUNOLOGY | 2022 | 7.3 | 21.4 | 1.83 | 2025-06-25 | 25 | 22 | periodontitis; miRNA; exosome; saliva; diabetes; insulin resistance; inflammation | DIABETES-MELLITUS; BIOMARKERS; DISEASE; CD69 | diabetes; exosome; inflammation; insulin resistance; miRNA; periodontitis; saliva | Adult; Aged; Animals; Diabetes Mellitus, Type 2; Exosomes; Female; Humans; Insulin Resistance; Male; Mice; MicroRNAs; Middle Aged; Periodontitis; Saliva; amyloid beta protein; interleukin 17; microRNA; transcription factor FOXP3; tumor necrosis factor; microRNA; MIRN25 microRNA, human; MIRN25 microRNA, mouse; alveolar bone; animal experiment; animal model; animal tissue; Article; bone density; C57BL 6 mouse; CD4+ T lymphocyte; chow diet; controlled study; diabetes mellitus; diabetic patient; dysbiosis; exosome; flow cytometry; fluorescence activated cell sorting; gene knockdown; glucose blood level; glucose tolerance test; glycemic control; immune response; inflammation; informed consent; insulin resistance; lipid diet; micro-computed tomography; microenvironment; mouse; non insulin dependent diabetes mellitus; nonhuman; obesity; periodontitis; prevalence; regulatory T lymphocyte; synchrotron radiation; Th17 cell; tumor associated leukocyte; adult; aged; animal; exosome; female; human; immunology; insulin resistance; male; middle aged; periodontitis; saliva | English | 2022 | 2022-01-07 | 10.3389/fimmu.2021.775046 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Ensemble inequivalence and negative extensibility in a strongly stretched wormlike chain with fluctuating bending stiffness | Many semiflexible polymers exhibit fluctuations in the local bending stiffness along their contour. This may be due to intrinsic conformational changes (e.g., denaturation bubble formation in double stranded DNA or helix-coil transition in polypeptides) or the reversible adsorption and desorption of molecules from the polymer's environment (e.g., DNA-protein interactions or hybridization of oligonucleotides). In this article, we analyze the tensile elasticity of a strongly stretched wormlike chain, which consists of N concatenated segments, where each segment can be in one of two states, A or B, which differ in bending stiffness. We call this model the reversible wormlike chain (rWLC) model. In the Gibbs (fixed-force, isotensional) ensemble, we obtain analytic expressions for the force-extension relation and the mean fraction of B segments. We show that, under certain conditions, there is a tension-induced crossover from a mostly A to a mostly B rWLC. In the Helmholtz (fixed-extension, isometric) ensemble, we obtain analytic expressions up to a summation. We show that, for finite N, there is marked ensemble inequivalence. Remarkably, in the Helmholtz ensemble, the rWLC can exhibit negative extensibility and multiple peaks. | Benetatos, Panayotis | Kyungpook Natl Univ, Dept Phys, 80 Daehakro, Daegu 41566, South Korea | Benetatos, Panayotis/AAT-5957-2021 | 6507575810 | pben@knu.ac.kr; | JOURNAL OF CHEMICAL PHYSICS | J CHEM PHYS | 0021-9606 | 1089-7690 | 157 | 16 | SCIE | CHEMISTRY, PHYSICAL;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2022 | 4.4 | 21.4 | 0.64 | 2025-06-25 | 7 | 7 | FREELY JOINTED CHAIN; DNA; TRANSITION; ELASTICITY; EQUIVALENCE; COPOLYMERS; MOLECULES; EXTENSION; BINDING; MODEL | DNA; Elasticity; Mechanical Phenomena; Polymers; Stiffness; DNA; polymer; Adsorption and desorptions; Analytic expressions; Bending stiffness; Conformational change; Ensemble inequivalence; Helix-coil transitions; Local bending; Reversible adsorption; Semiflexible polymers; Wormlike chain; chemistry; elasticity; mechanics; Oligonucleotides | English | 2022 | 2022-10-28 | 10.1063/5.0112552 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Epigenetic therapy reprograms M2-type tumor-associated macrophages into an M1-like phenotype by upregulating miR-7083-5p | Reprogramming M2-type, pro-tumoral tumor-associated macrophages (TAMs) into M1-type, anti-tumoral macrophages is a key strategy in cancer therapy. In this study, we exploited epigenetic therapy using the DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-aza-dC) and the histone deacetylation inhibitor trichostatin A (TSA), to reprogram M2-type macrophages into an M1-like phenotype. Treatment of M2-type macrophages with the combination of 5-aza-dC and TSA decreased the levels of M2 macrophage cytokines while increasing those of M1 macrophage cytokines, as compared to the use of either therapy alone. Conditioned medium of M2 macrophages treated with the combination of 5-aza-dC and TSA sensitized the tumor cells to paclitaxel. Moreover, treatment with the combination inhibited tumor growth and improved anti-tumor immunity in the tumor microenvironment. Depletion of macrophages reduced the anti-tumor growth activity of the combination therapy. Profiling of miRNAs revealed that the expression of miR-7083-5p was remarkably upregulated in M2 macrophages, following treatment with 5-aza-dC and TSA. Transfection of miR-7083-5p reprogrammed the M2-type macrophages towards an M1-like phenotype, and adoptive transfer of M2 macrophages pre-treated with miR-7083-5p into mice inhibited tumor growth. miR-7083-5p inhibited the expression of colony-stimulating factor 2 receptor alpha and CD43 as candidate targets. These results show that epigenetic therapy upon treatment with the combination of 5-aza-dC and TSA skews M2-type TAMs towards the M1-like phenotype by upregulating miR-7083-5p, which contributes to the inhibition of tumor growth. | Vadevoo, Sri Murugan Poongkavithai; Gunassekaran, Gowri Rangaswamy; Yoo, Jae Do; Kwon, Tae-Hwan; Hur, Keun; Chae, Sehyun; Lee, Byungheon | Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst CMRI, Daegu, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu, South Korea; Korea Brain Res Inst KBRI, Daegu, South Korea | Hur, Keun/G-9513-2011; Kwon, Tae-Hwan/ABA-1981-2020 | 56663280000; 36028043400; 57216203097; 7202206089; 8861888000; 55305469400; 16304374900 | leebh@knu.ac.kr; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 13 | SCIE | IMMUNOLOGY | 2022 | 7.3 | 21.4 | 1.16 | 2025-06-25 | 18 | 14 | 5-aza-2'-deoxycytidine; epigenetic therapy; macrophage reprogramming; miR-7083-5p; trichostatin A | EXPRESSION; POLARIZATION; RESPONSES; PROGRESSION; ACTIVATION; CANCER; CELLS; CD43 | 5-aza-2’-deoxycytidine; epigenetic therapy; macrophage reprogramming; miR-7083-5p; trichostatin A | Animals; Epigenomics; Mice; Protein Processing, Post-Translational; Transfection; Tumor-Associated Macrophages; arginase 1; beta actin; clodronic acid; colony stimulating factor 2 receptor alpha; decitabine; gamma interferon; inducible nitric oxide synthase; interleukin 10; interleukin 12p40; interleukin 4; interleukin 6; leukosialin; luciferin; membrane protein; microRNA; microRNA 7083 5p; OKT 8; paclitaxel; transforming growth factor beta; trichostatin A; unclassified drug; 3' untranslated region; 4T1 cell line; adoptive transfer; animal cell; animal experiment; animal model; animal tissue; Article; bioluminescence; cancer therapy; CD8+ T lymphocyte; cell viability assay; controlled study; down regulation; enzyme linked immunosorbent assay; epigenetics; female; flow cytometry; genetic transfection; Lewis lung carcinoma cell line; luciferase assay; M2 tumor-associated macrophage; male; microarray analysis; monocyte; mouse; nonhuman; nuclear reprogramming; phenotype; polarization; reverse transcription polymerase chain reaction; tumor growth; tumor immunity; tumor volume; upregulation; animal; protein processing | English | 2022 | 2022-11-22 | 10.3389/fimmu.2022.976196 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Experimental investigation on the thermal appraisal of heat pipe-evacuated tube collector-based water heating system integrated with PCM | There is a great deal of research being done on the performance of solar collectors. Evacuated tube solar col-lectors are a mature technology that has proved reassuring performance for heat generation. However, low thermal efficiency remains their main challenge. Therefore, research to improve the efficiency of Evacuated Tube of Solar has continued to date based on some new approaches. The present study presented various designs of Evacuated Tube of Solar collector (ETSC) thermally enhanced by the addition of reflectors and thermal storage units with phase change materials and nanoparticles. The proposed models were assessed during different pe-riods and different zones in Tunisia, especially in the Northern and Southern regions. This work established the energy balance of solar thermal systems determined by the input/output method. Assumptions and mathematical relations are presented for the proposed designs. Additionally, measured and regression useful energy as a function of the daily cumulative global solar energy of all ETSC-types was also evaluated. Research gaps in this field are identified and future research trends and directions are recommended. | Bouadila, Salwa; Baddadi, Sara; Rehman, Tauseef-ur; Ayed, Rabeb | Ctr Rech & Technol Energie, Technopole Borj Cedria,BP 95, Ben Arous, Tunisia; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | Rehman, Tauseef-ur/AAE-3086-2022; BOUADILA, Salwa/AAP-6218-2020 | 55710749600; 57205263214; 57159403400; 57875330600 | salwa.bouadila@crten.rnrt.tn; | RENEWABLE ENERGY | RENEW ENERG | 0960-1481 | 1879-0682 | 199 | SCIE | ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2022 | 8.7 | 21.4 | 1.48 | 2025-06-25 | 26 | 30 | Energy efficiency; ETSC; Latent heat storage; PCM | SOLAR AIR HEATER; PHASE-CHANGE MATERIALS; LONG-TERM PERFORMANCE; ENERGY; STORAGE; ENHANCEMENT; TUNISIA | Energy efficiency; ETSC; Latent heat storage; PCM | Collector efficiency; Heat pipes; Heat storage; Phase change materials; Solar heating; Solar thermal energy; Tubes (components); Evacuated tube collectors; Evacuated tube of solar collector; Evacuated tube solar collector; Evacuated tubes; Experimental investigations; Latent heat storage; Performance; Thermal; Thermal-efficiency; Water heating systems; energy efficiency; integrated approach; performance assessment; Energy efficiency | English | 2022 | 2022-11 | 10.1016/j.renene.2022.09.004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Kinetics of vaccine-induced neutralizing antibody titers and estimated protective immunity against wild-type SARS-CoV-2 and the Delta variant: A prospective nationwide cohort study comparing three COVID-19 vaccination protocols in South Korea | IntroductionDespite vaccine development, the COVID-19 pandemic is ongoing due to immunity-escaping variants of concern (VOCs). Estimations of vaccine-induced protective immunity against VOCs are essential for setting proper COVID-19 vaccination policy. MethodsWe performed plaque-reduction neutralizing tests (PRNTs) using sera from healthcare workers (HCWs) collected from baseline to six months after COVID-19 vaccination and from convalescent COVID-19 patients. The 20.2% of the mean PRNT titer of convalescent sera was used as 50% protective value, and the percentage of HCWs with protective immunity for each week (percent-week) was compared among vaccination groups. A correlation equation was deduced between a PRNT 50% neutralizing dose (ND50) against wild type (WT) SARS-CoV-2 and that of the Delta variant. ResultsWe conducted PRNTs on 1,287 serum samples from 297 HCWs (99 HCWs who received homologous ChAdOx1 vaccination (ChAd), 99 from HCWs who received homologous BNT162b2 (BNT), and 99 from HCWs who received heterologous ChAd followed by BNT (ChAd-BNT)). Using 365 serum samples from 116 convalescent COVID-19 patients, PRNT ND50 of 118.25 was derived as 50% protective value. The 6-month cumulative percentage of HCWs with protective immunity against WT SARS-CoV-2 was highest in the BNT group (2297.0 percent-week), followed by the ChAd-BNT (1576.8) and ChAd (1403.0) groups. In the inter-group comparison, protective percentage of the BNT group (median 96.0%, IQR 91.2-99.2%) was comparable to the ChAd-BNT group (median 85.4%, IQR 15.7-100%; P =0.117) and significantly higher than the ChAd group (median 60.1%, IQR 20.0-87.1%; P <0.001). When Delta PRNT was estimated using the correlation equation, protective immunity at the 6-month waning point was markedly decreased (28.3% for ChAd group, 52.5% for BNT, and 66.7% for ChAd-BNT). ConclusionDecreased vaccine-induced protective immunity at the 6-month waning point and lesser response against the Delta variant may explain the Delta-dominated outbreak of late 2021. Follow-up studies for newly-emerging VOCs would also be needed. | Nham, Eliel; Ko, Jae-Hoon; Song, Kyoung-Ho; Choi, Ju-Yeon; Kim, Eu Suk; Kim, Hye-Jin; Kim, Byoungguk; Lim, Hee-Young; Kim, Kyung-Chang; Jang, Hee-Chang; Lee, Kyoung Hwa; Song, Young Goo; Baek, Yae Jee; Ahn, Jin Young; Choi, Jun Yong; Kim, Yong Chan; Park, Yoon Soo; Choi, Won Suk; Bae, Seongman; Kim, Sung-Han; Kang, Eun-Suk; Jeong, Hye Won; Kim, Shin-Woo; Kwon, Ki Tae; Kim, Sung Soon; Peck, Kyong Ran | Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Div Infect Dis,Dept Med, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med, Seongnam, South Korea; Natl Inst Infect Dis, Korea Natl Inst Hlth, Korea Dis Control & Prevent Agcy, Cheongju, South Korea; Yonsei Univ, Gangnam Severance Hosp, Coll Med, Dept Internal Med,Div Infect Dis, Seoul, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Yongin Severance Hosp, Coll Med, Dept Internal Med,Div Infect Dis, Yongin, South Korea; Korea Univ, Ansan Hosp, Coll Med, Dept Internal Med,Div Infect Dis, Ansan, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Infect Dis, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Lab Med & Genet, Seoul, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Div Infect Dis, Cheongju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med,Div Infectious Dis,, Daegu, South Korea | Kim, Sang Hyuk/AFE-5646-2022; Choi, Won Suk/V-2730-2017; Kim, Eu/J-5424-2012; Choi, Jah/AAA-4835-2022; Hwang, Soyoon/HHM-5762-2022; Nham, Eliel/AFP-2784-2022; Park, Yoon/C-6472-2015; Kim, Jwa/AAH-9915-2021; Lee, Kyoung-Hwa/AAJ-5213-2021; Peck, Kyong Ran/AGV-5205-2022; Jeong, Hye/AET-1982-2022; Choi, Won/V-2730-2017 | 57190045330; 55804188300; 23398486700; 57203732512; 22938086900; 59412639300; 57792610600; 58277172200; 52063321200; 7202135138; 56955948100; 55675198500; 57216363310; 57225850337; 57791298700; 36486497700; 7405373036; 56718971800; 57189690904; 55133790400; 20234715300; 13103042700; 8710731500; 9733850500; 57218856689; 55664295200 | hwjeong@chungbuk.ac.kr;ksw2kms@knu.ac.kr;ktkwon@knu.ac.kr;sungskim@korea.kr;krpeck@skku.edu; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 13 | SCIE | IMMUNOLOGY | 2022 | 7.3 | 21.4 | 1.25 | 2025-06-25 | 16 | 17 | protective immunity; vaccination; neutralizing antibody; SARS-CoV-2; COVID-19 | COVID-19; neutralizing antibody; protective immunity; SARS-CoV-2; vaccination | Antibodies, Neutralizing; Antibodies, Viral; BNT162 Vaccine; Cohort Studies; COVID-19; COVID-19 Vaccines; Humans; Immunization, Passive; Kinetics; Pandemics; Prospective Studies; Republic of Korea; SARS-CoV-2; Vaccination; Viral Vaccines; convalescent serum; neutralizing antibody; nonsteroid antiinflammatory agent; nucleocapsid protein; paracetamol; tozinameran; vaxzevria; neutralizing antibody; virus antibody; virus vaccine; adult; antibody response; antibody titer; arthralgia; Article; body mass; chemoluminescence; chill; cohort analysis; convalescence; coronavirus disease 2019; diarrhea; fatigue; female; fever; follow up; headache; health care personnel; human; immunity; kinetics; major clinical study; male; myalgia; pain; plaque reduction neutralization test; reverse transcription polymerase chain reaction; SARS-CoV-2 Delta; Severe acute respiratory syndrome coronavirus 2; skin redness; South Korea; swelling; vaccination; variant of concern; virus neutralization; vomiting; epidemiology; kinetics; pandemic; passive immunization; prevention and control; prospective study; therapy; vaccination | English | 2022 | 2022-09-23 | 10.3389/fimmu.2022.968105 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Correction | Non-Invasive Diagnosis for Acute Rejection Using Urinary mRNA Signature Reflecting Allograft Status in Kidney Transplantation (vol 12, 656632, 2021) | Seo, Jung-Woo; Lee, Yu-Ho; Tae, Dong Hyun; Park, Seon Hwa; Moon, Ju-Young; Jeong, Kyung Hwan; Kim, Chan-Duck; Chung, Byung Ha; Park, Jae Berm; Kim, Yeong Hoon; Seok, Junhee; Joo, Sun Hyung; Lee, Seung Hwan; Lee, Jong Soo; Lee, Sang-Ho | Kyung Hee Univ, Med Sci Inst, Core Res Lab, Hosp Gangdong, Seoul, South Korea; Kyung Hee Univ Hosp Gangdong, Dept Internal Med, Div Nephrol, Seoul, South Korea; Korea Univ, Sch Elect Engn, Seoul, South Korea; Kyung Hee Univ, Coll Med, Dept Internal Med, Div Nephrol, Seoul, South Korea; Kyungpook Natl Univ, Dept Internal Med, Div Nephrol, Sch Med, Daegu, South Korea; Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Internal Med,Div Nephrol, Seoul, South Korea; Sungkyunkwan Univ, Dept Surg, Samsung Hosp, Seoul, South Korea; Inje Univ, Coll Med, Dept Internal Med, Div Nephrol,Busan Paik Hosp, Busan, South Korea; Kyung Hee Univ, Dept Surg, Hosp Gangdong, Seoul, South Korea; Univ Ulsan, Dept Internal Med, Div Nephrol, Coll Med, Ulsan, South Korea | Moon, Ju-Young/T-6959-2019; Lee, Seung/AAI-1191-2020; Kim, Tae-Hee/AAN-9079-2021; Kim, Hyoungnae/JXN-1329-2024; , Prof/W-5371-2019 | 56678212900; 56344334200; 57194702774; 57193847481; 7403231326; 8443579300; 8558530700; 57201863822; 13605451500; 7410196419; 24069490100; 25928515100; 55989532800; 57201264463; 55890136000 | lshkidney@khu.ac.kr; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 12 | SCIE | IMMUNOLOGY | 2022 | 7.3 | 21.4 | 0 | 2025-06-25 | 0 | 0 | kidney; transplantation; non-invasive diagnosis; acute rejection; urinary mRNA | acute rejection; kidney; non-invasive diagnosis; transplantation; urinary mRNA | erratum | English | 2022 | 2022-01-06 | 10.3389/fimmu.2021.825243 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Performance and wake analysis of horizontal axis tidal current turbine using Improved Delayed Detached Eddy Simulation | This paper presents the results of hydrodynamic performance and wake assessment for a horizontal axis tidal current turbine. The three-dimensional instantaneous flow field is resolved utilizing the Improved Delayed Detached Eddy Simulation (IDDES) turbulence model and polyhedral mesh. The rotor rotation is simulated by employing the sliding mesh approach. The simulation results using turbulence model of k u Shear Stress Transport are also presented for comparison. The simulated thrust and power coefficients and wake characteristics are validated against published experimental results. It is shown that the performance and wake velocity predicted by IDDES are closer to the experimental values than those predicted by k -u Shear Stress Transport model. In determining the pressure coefficient, only IDDES captures the time-varying fluctuations pertaining to blade generated turbulence. The oscillations in phase-averaged performance coefficients are substantially larger for IDDES because the inflow turbulence in this model is more realistically resolved using Synthetic Eddy Method. The IDDES predicts more detailed vortex structures which has impact on accurate determination of blade pressure distribution, energy dissipation rate and downstream flow field. It is demonstrated that the IDDES model is capable to satisfactorily simulate the hydrodynamics of a horizontal axis tidal current turbine.(c) 2021 Elsevier Ltd. All rights reserved. | Faizan, Muhammad; Badshah, Saeed; Badshah, Mujahid; Haider, Basharat Ali | Int Islamic Univ Islamabad, Dept Mech Engn, Islamabad 44000, Pakistan; Kyungpook Natl Univ, Sch Mech Engn, Daegu, South Korea | Haider, Basharat/B-5887-2015; Faizan, Muhammad/JLK-8272-2023; Badshah, Saeed/H-4346-2018; Haider, Basharat Ali/B-5887-2015; Badshah, Mujahid/AAA-5129-2019 | 59750394000; 55818414400; 57188694442; 36805990000 | faizan_mech@outlook.com;saeed.badshah@iiu.edu.pk;mujahidbadshah@yahoo.com;bahaider@knu.ac.kr; | RENEWABLE ENERGY | RENEW ENERG | 0960-1481 | 1879-0682 | 184 | SCIE | ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2022 | 8.7 | 21.4 | 0.84 | 2025-06-25 | 17 | 17 | Performance; Wake; Polyhedral mesh; IDDES; Horizontal axis tidal turbine | MARINE CURRENT TURBINES; WIND TURBINE; BOUNDARY PROXIMITY; TURBULENCE; FLOW; CFD; TECHNOLOGIES; DESIGN; MODELS; SHEAR | Horizontal axis tidal turbine; IDDES; Performance; Polyhedral mesh; Wake | Energy dissipation; Flow fields; Flow separation; Hydrodynamics; Mesh generation; Ocean currents; Shear flow; Shear stress; Tidal power; Turbines; Turbulence models; Vortex flow; Vorticity; Current turbines; Horizontal axis; Horizontal axis tidal turbine; Improved delayed detached eddy simulations; Performance; Performances analysis; Polyhedral meshes; Shear-stress transport; Tidal currents; Tidal turbines; hydrodynamics; large eddy simulation; performance assessment; three-dimensional modeling; tidal current; turbine; wake; Wakes | English | 2022 | 2022-01 | 10.1016/j.renene.2021.11.107 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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