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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | NEPSC2, the North Ecliptic Pole SCUBA-2 survey: 850-μm map and catalogue of 850-μm-selected sources over 2 deg² | We present an 850-mu m mosaic map and extracted catalogue of submillimetre sources in the extended North Ecliptic Pole (NEP) region over about 2 deg(2). The 850-mu m map is constructed using newly obtained observations by SCUBA-2 at the East Asian Observatory's James Clerk Maxwell Telescope, carried out using the observatory's large programme opportunities. The recent 850-mu m survey has extended the submillimetre data coverage by almost a factor of 4 compared to previous surveys, with a depth of sigma(rms) = 1.0-2.3 mJy beam(-1). The catalogue contains 549 sources selected above a significance level of 4 sigma, where the false-detection rate is 10 per cent; a higher threshold of 4.5 sigma is required in order to achieve a false-detection rate below 3 per cent, which results in 342 sources being selected. Despite the large spatial variation of the noise, the deboosted flux density of sources is comparable to results from the SCUBA-2 Cosmology Legacy Survey, which covered the central 0.6 deg(2) of our survey area with better sensitivity. We construct the source counts at 850 mu m, finding results in agreement with other 850-mu m surveys in cosmological blank fields over S-850 = 4-15 mJy. We find a slight excess of bright galaxies (S-850 > 15 mJy), which can be considered to be at z(phot) = 2-4. The 850-mu m data add valuable long-wavelength information to mid-infrared-selected sources from the AKARI NEP-deep and NEP-wide surveys, which will be helpful in preparing for future near-infrared to millimetre wavelength observations in the NEP region. Our 850-mu m mosaic map and source catalogue will be made publicly available. | Shim, Hyunjin; Kim, Yeonsik; Lee, Dongseob; Lee, Hyung Mok; Goto, Tomo; Matsuhara, Hideo; Scott, Douglas; Serjeant, Stephen; Ao, Yiping; Barrufet, Laia; Chapman, Scott; Clements, David L.; Conselice, Christopher J.; Greve, Thomas R.; Hashimoto, Tetsuya; Hwang, Ho Seong; Im, Myungshin; Jeong, Woong-Seob; Jiang, Linhua; Kim, Minjin; Kim, Seong Jin; Kong, Albert K. H.; Koprowski, Maciej; Marchetti, Lucia; Michalowski, Michal J.; Parsons, Harriet; Pearson, Chris; Seo, Hyunjong; Toba, Yoshiki; White, Glenn | Kyungpook Natl Univ, Dept Earth Sci Educ, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 41566, South Korea; Korea Astron & Space Sci Inst, Daejeon 34055, South Korea; Seoul Natl Univ, Dept Phys & Astron, Seoul 08826, South Korea; Natl Tsing Hua Univ, Inst Astron, 101,Sect 2,Kuang Fu Rd, Hsinchu 30013, Taiwan; Japan Aerosp Explorat Agcy, Inst Space & Astronaut Sci, Chuo Ku, 3-1-1 Yoshinodai, Sagamihara, Kanagawa 2525210, Japan; Univ British Columbia, Dept Phys & Astron, 6224 Agr Rd, Vancouver, BC V6T 1Z1, Canada; Open Univ, Sch Phys Sci, Milton Keynes MK7 6AA, Bucks, England; Chinese Acad Sci, Purple Mt Observ, Nanjing 210033, Peoples R China; Chinese Acad Sci, Key Lab Radio Astron, Nanjing 210033, Peoples R China; Univ Sci & Technol China, Sch Astron & Space Sci, Hefei 230026, Anhui, Peoples R China; European Space Astron Ctr, E-28691 Villanueva De La Canada, Spain; STFC Rutherford Appleton Lab, RAL Space, Didcot OX11 0QX, Oxon, England; Dalhouise Univ, Dept Phys & Atmospher Sci, Halifax, NS B3H 4R2, Canada; Imperial Coll London, Blackett Lab, Prince Consort Rd, London SW7 2AZ, England; Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England; UCL, Dept Phys & Astron, Gower St, London WC1E 6BT, England; Tech Univ Denmark, Cosm Dawn Ctr DAWN, DK-2800 Lyngby, Denmark; Tech Univ Denmark, DTU Space, Natl Space Inst, Elektrovej 327, DK-2800 Lyngby, Denmark; Natl Tsing Hua Univ, Ctr Informat & Computat Astron CICA, 101,Sect 2,Kuang Fu Rd, Hsinchu 30013, Taiwan; Peking Univ, Kavli Inst Astron & Astrophys, 5 Yiheyuan Rd, Beijing 100871, Peoples R China; Nicolaus Copernicus Univ, Inst Astron, Fac Phys Astron & Informat, Grudziadzka 5, PL-87100 Torun, Poland; Univ Cape Town, Dept Astron, Private Bag X3, ZA-7701 Cape Town, South Africa; INAF Ist Radioastron, Via Gobetti 101, I-40129 Bologna, Italy; Adam Mickiewicz Univ, Fac Phys, Astron Observ Inst, Ul Sloneczna 36, PL-60286 Poznan, Poland; East Asian Observ, 660 N Aohoku Pl,Univ Pk, Hilo, HI 96720 USA; Univ Oxford, Oxford Astrophys, Keble Rd, Oxford OX1 3RH, England; Kyoto Univ, Dept Astron, Sakyo Ku, Kitashirakawa Oiwake Cho, Kyoto 6068502, Japan; Acad Sinica, AS NTU, Inst Astron & Astrophys, 11F Astron Math Bldg,1,Sect 4,Roosevelt Rd, Taipei 10617, Taiwan; Ehime Univ, Res Ctr Space & Cosm Evolut, 2-5 Bunkyo Cho, Matsuyama, Ehime 7908577, Japan | Michałowski, Michał/AAQ-4789-2021; Koprowski, Maciej/M-7525-2019; White, Glenn/H-5823-2013; Hashimoto, Tetsuya/ABG-3643-2021; Shim, Hyunjin/LZI-7486-2025; Serjeant, Stephen/AAN-1908-2021; Im, Myungshin/B-3436-2013; Marchetti, Lucia/AAC-7835-2021; HWANG, Ho/AAS-6010-2020; Conselice, Christopher/B-4348-2013 | 14061137700; 57220183432; 57218674853; 16026277600; 57220182522; 7003505733; 7404952697; 7003485288; 7003967931; 57201651740; 24447889300; 25924805300; 7003910265; 10339159000; 24518043000; 15131707100; 7004267711; 7102145940; 14058258000; 56898213300; 57070819300; 35185316600; 56038935500; 36126412600; 15822545300; 35096693300; 55531949600; 35278506600; 37068332400; 7403458984 | hjshim@knu.ac.kr; | MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY | MON NOT R ASTRON SOC | 0035-8711 | 1365-2966 | 498 | 4 | SCIE | ASTRONOMY & ASTROPHYSICS | 2020 | 5.287 | 22.8 | 0.68 | 2025-06-25 | 19 | 21 | galaxies: evolution; galaxies: photometry; galaxies: starburst; submillimetre: galaxies | COSMOLOGY LEGACY SURVEY; DEGREE EXTRAGALACTIC SURVEY; DEEP-FIELD-SOUTH; MU-M; SUBMILLIMETER GALAXIES; ALMA SURVEY; STAR-FORMATION; POPULATION; DUST; IDENTIFICATIONS | Galaxies: evolution; Galaxies: photometry; Galaxies: starburst; Submillimetre: galaxies | English | 2020 | 2020-11 | 10.1093/mnras/staa2621 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Performance Comparison of Spiral-Wound and Plate-and-Frame Forward Osmosis Membrane Module | We compared two representative forward osmosis (FO) modules-spiral-wound (SW) and plate-and-frame (PF)-to provide practical information for the selection of FO element for a large-scale FO process. The FO operating performance of commercially available SW FO and PF FO was explored under different membrane area and flow rate conditions. The performance trend as a function of the membrane was obtained by adjusting the number of serially connected elements. Although SW FO and PF FO elements exhibited comparable feed pressure drops, SW FO demonstrated a significantly higher draw channel pressure drop than PF FO. Furthermore, the significant draw pressure drop in SW FO increased the draw inlet pressure, consequently limiting the number of serially connected elements. For example, the maximum number of serially connected elements for the normal operation was three elements for SW FO (45.9 m(2)) but nine elements for PF FO (63 m(2)) when the flow rate of 10 LMP was applied for feed and draw streams. Additionally, a footprint analysis indicated that SW FO module exhibited a slightly larger footprint than PF FO. Under investigated conditions, PF FO exhibited relatively better performance than SW FO. Therefore, this pilot-scale FO study highlighted the need to reduce the flow resistance of SW FO draw channel to take advantage of the high packing density of the SW element. | Lee, Sungyun | Kyungpook Natl Univ, Dept Civil Environm Engn, Sch Disaster Prevent & Environm Engn, 2559 Gyeongsang Daero, Sangju Si 37224, Gyeongsangbuk D, South Korea; Korea Inst Machinery & Mat, Dept Environm Machinery, Daejeon 34103, South Korea | Lee, Sang-Eun/HJH-1132-2023 | 36438267000 | sungyunlee@knu.ac.kr; | MEMBRANES | MEMBRANES-BASEL | 2077-0375 | 10 | 11 | SCIE | CHEMISTRY, PHYSICAL;ENGINEERING, CHEMICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;POLYMER SCIENCE | 2020 | 4.106 | 22.8 | 0.55 | 2025-06-25 | 18 | 16 | forward osmosis; spiral-wound; plate-and-frame; pressure drop; serial connection; footprint | CONCENTRATION POLARIZATION; FO MEMBRANE; PRESSURE; SCALE; NANOPARTICLES; FABRICATION; PARAMETERS; SUBSTRATE; BEHAVIOR; SPACERS | Footprint; Forward osmosis; Plate-and-frame; Pressure drop; Serial connection; Spiral-wound | Drops; Channel pressure drop; Flow rate conditions; Footprint analysis; Forward osmosis membranes; High packing density; Normal operations; Operating performance; Performance comparison; Pressure drop | English | 2020 | 2020-11 | 10.3390/membranes10110318 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | S2COSMOS: Evolution of gas mass with redshift using dust emission | We investigate the evolution of the gas mass fraction for galaxies in the COSMOS field using submillimetre emission from dust at 850 mu m. We use stacking methodologies on the 850 mu m S2COSMOS map to derive the gas mass fraction of galaxies out to high redshifts, 0 <= z <= 5, for galaxies with stellar masses of 10(9.5) < M-*(M-circle dot) < 10(11.75). In comparison to previous literature studies we extend to higher redshifts, include more normal star-forming galaxies (on the main sequence), and also investigate the evolution of the gas mass fraction split by star-forming and passive galaxy populations. We find our stacking results broadly agree with scaling relations in the literature. We find tentative evidence for a peak in the gas mass fraction of galaxies at around z similar to 2.5-3, just before the peak of the star formation history of the Universe. We find that passive galaxies are particularly devoid of gas, compared to the star-forming population. We find that even at high redshifts, high stellar mass galaxies still contain significant amounts of gas. | Millard, Jenifer S.; Eales, Stephen A.; Smith, M. W. L.; Gomez, H. L.; Malek, K.; Simpson, J. M.; Peng, Y.; Sawicki, M.; Beeston, R. A.; Bunker, Andrew; Ao, Y.; Babul, A.; Ho, L. C.; Hwang, Ho Seong; Michalowski, M. J.; Scoville, N.; Shim, H.; Toba, Y. | Cardiff Univ, Sch Phys & Astron, Cardiff CF24 3AA, Wales; Aix Marseille Univ, CNRS, CNES, LAM, F-13007 Marseille, France; Natl Ctr Nucl Res, Ul Hoza 69, PL-00681 Warsaw, Poland; Acad Sinica, Inst Astron & Astrophys, 1,Sect 4,Roosevelt Rd, Taipei 10617, Taiwan; Peking Univ, Kavli Inst Astron & Astrophys, 5 Yiheyuan Rd, Beijing 100871, Peoples R China; St Marys Univ, Inst Computat Astrophys, Halifax, NS B3H 3C3, Canada; St Marys Univ, Dept Astron & Phys, Halifax, NS B3H 3C3, Canada; Univ Oxford, Sub Dept Astrophys, Dept Phys, Denys Wilkinson Bldg,Keble Rd, Oxford OX1 3RH, England; Chinese Acad Sci, Purple Mt Observ, 8 Yuanhua Rd, Nanjing 210034, Peoples R China; Chinese Acad Sci, Key Lab Radio Astron, 8 Yuanhua Rd, Nanjing 210034, Peoples R China; Univ Victoria, Dept Phys & Astron, 3800 Finnerty Rd, Victoria, BC V8P 1A1, Canada; Peking Univ, Sch Phys, Dept Astron, 5 Yiheyuan Rd, Beijing 100871, Peoples R China; Korea Astron & Space Sci Inst, 776 Daedeokdae Ro, Daejeon 34055, South Korea; Adam Mickiewicz Univ, Fac Phys, Astron Observ Inst, Ul Sloneczna 36, PL-60286 Poznan, Poland; CALTECH, MC 249-17,1200 East Calif Blvd, Pasadena, CA 91125 USA; Kyungpook Natl Univ, Dept Earth Sci Educ, 80 Daehak Ro, Daegu 41566, South Korea; Kyoto Univ, Dept Astron, Sakyo Ku, Kitashirakawa Oiwake Cho, Kyoto 6068502, Japan; Ehime Univ, Res Ctr Space & Cosm Evolut, 2-5 Bunkyo Cho, Matsuyama, Ehime 7908577, Japan | Bunker, Alex/ABC-2638-2021; Smith, Matthew/HMD-7992-2023; HWANG, Ho/AAS-6010-2020; Shim, Hyunjin/LZI-7486-2025; Peng, Yingjie/B-1280-2013; MAŁEK, KATARZYNA/A-1254-2012; Michałowski, Michał/AAQ-4789-2021; Gomez, Haley/C-2800-2009; Sawicki, Marcin/JZT-9160-2024; Babul, Arif/E-2730-2010 | 57203306566; 24340000400; 15037385800; 8709470300; 56210521800; 55430490600; 25937428700; 57203088473; 57203393884; 7006104330; 7003967931; 7003750215; 35229428100; 15131707100; 15822545300; 7005476593; 14061137700; 37068332400 | jenifer.milard@astro.cf.ac.uk;jenifer.millard@astro.cf.ac.uk; | MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY | MON NOT R ASTRON SOC | 0035-8711 | 1365-2966 | 494 | 1 | SCIE | ASTRONOMY & ASTROPHYSICS | 2020 | 5.287 | 22.8 | 0.68 | 2025-06-25 | 18 | 18 | galaxies: evolution; galaxies: ISM; galaxies: statistics; submillimetre: ISM submillimetre: galaxies | COSMOLOGY LEGACY SURVEY; STAR-FORMING GALAXIES; MOLECULAR GAS; COSMIC EVOLUTION; HERSCHEL-ATLAS; STELLAR MASS; PANCHROMATIC PHOTOMETRY; INFRARED-EMISSION; SIMPLE-MODEL; COLD DUST | Galaxies: evolution; Galaxies: ISM; Galaxies: statistics; Submillimetre: galaxies; Submillimetre: ISM | Cosmology; Dust; Gases; Stars; Galaxies: ISM; Galaxies: statistics; Galaxy evolution; Gas mass; High-redshift; Mass-fraction; Stackings; Submillimeter: galaxies; Submillimeter: ISM; Submillimetre; Galaxies | English | 2020 | 2020-05 | 10.1093/mnras/staa609 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Stellar properties of the host galaxy of an ultraluminous X-ray source in NGC 5252 | An ultraluminous X-ray source (ULX) in NGC 5252 has been known as a strong candidate for an off-nuclear intermediate-mass black hole (IMBH). We present near-infrared imaging data of the ULX obtained with the William Herschel Telescope. Using this data we estimate a stellar mass associated with the ULX of approximate to 10(7.9 +/- 10.1) M-circle dot, suggesting that it could be (the remnant of) a dwarf galaxy that is in the process of merging with NGC 5252. Based on a correlation between the mass of the central black hole (BH) and host galaxy, the ULX is powered by a 10(5) M-circle dot BH. Alternatively, if the BH mass is approximate to 10(6) M-circle dot or larger, the host galaxy of the ULX must have been heavily stripped during the merger. The ULX K-s-band luminosity is two orders of magnitude smaller than that expected from an ordinary active galactic nucleus with the observed [O III] luminosity, which also suggests the ULX lacks a dusty torus. We discuss how these findings provide suggestive evidence that the ULX is hosting an IMBH. | Kim, Minjin; Lopez, Kristhell M.; Jonker, Peter G.; Ho, Luis C.; Im, Myungshin | Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 41566, South Korea; SRON Netherlands Inst Space Res, Sorbonnelaan 2, NL-3584 CA Utrecht, Netherlands; Radboud Univ Nijmegen, Dept Astrophys, IMAPP, POB 9010, NL-6500 GL Nijmegen, Netherlands; Peking Univ, Kavli Inst Astron & Astrophys, Beijing 100871, Peoples R China; Peking Univ, Sch Phys, Dept Astron, Beijing 100871, Peoples R China; Seoul Natl Univ, Dept Phys & Astron, FPRD, Astron Program, 1 Gwanak Ro, Seoul 08826, South Korea | ; Kim, Minjin/AAU-9910-2020; Im, Myungshin/B-3436-2013 | 56898213300; 57209237475; 7005732591; 35229428100; 7004267711 | mkim@kasi.re.kr; | MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY | MON NOT R ASTRON SOC | 0035-8711 | 1365-2966 | 493 | 1 | SCIE | ASTRONOMY & ASTROPHYSICS | 2020 | 5.287 | 22.8 | 0.34 | 2025-06-25 | 8 | 8 | black hole physics; galaxies: active; galaxies: individual: NGC 5252; galaxies: Seyfert; X-rays: galaxies | SUPERMASSIVE BLACK-HOLE; ACTIVE GALACTIC NUCLEI; BROAD-LINE REGION; DWARF GALAXY; SOLAR MASSES; ULX; POPULATION; RESOLUTION; DISCOVERY; REDSHIFT | black hole physics; galaxies: active; galaxies: individual: NGC 5252; galaxies: Seyfert; X-rays: galaxies | English | 2020 | 2020-03 | 10.1093/mnrasl/slaa011 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | 3D reconstruction of small bowel lesions using stereo camera-based capsule endoscopy | Three-dimensional (3D) reconstruction of capsule endoscopic images has been attempted for a long time to obtain more information on small bowel structures. Due to the limited hardware resources of capsule size and battery capacity, software approaches have been studied but have mainly exhibited inherent limitations. Recently, stereo camera-based capsule endoscopy, which can perform hardware-enabled 3D reconstruction, has been developed. We aimed to evaluate the feasibility of newly developed 3D capsule endoscopy in clinical practice. This study was a prospective, single-arm, feasibility study conducted at two university-affiliated hospitals in South Korea. Small bowel evaluation was performed using a newly developed 3D capsule endoscope for patients with obscure gastrointestinal bleeding, suspected or established Crohn's disease, small bowel tumors, and abdominal pain of unknown origin. We assessed the technical limitations, performance, and safety of the new capsule endoscope. Thirty-one patients (20 men and 11 women; mean age: 44.5 years) were enrolled. There was no technical defect preventing adequate visualization of the small bowel. The overall completion rate was 77.4%, the detection rate was 64.5%, and there was no capsule retention. All capsule endoscopic procedures were completed uneventfully. In conclusion, newly developed 3D capsule endoscopy was safe and feasible, showing similar performance as conventional capsule endoscopy. Newly added features of 3D reconstruction and size measurement are expected to be useful in the characterization of subepithelial tumours. | Nam, Seung-Joo; Lim, Yun Jeong; Nam, Ji Hyung; Lee, Hyun Seok; Hwang, Youngbae; Park, Junseok; Chun, Hoon Jai | Kangwon Natl Univ, Sch Med, Dept Internal Med, Chunchon, South Korea; Dongguk Univ, Ilsan Hosp, Coll Med, Dept Internal Med, Goyang, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Chungbuk Natl Univ, Dept Elect Engn, Cheongju, South Korea; Soonchunhyang Univ, Coll Med, Dept Internal Med, Inst Digest Res,Digest Dis Ctr, Seoul, South Korea; Korea Univ, Coll Med, Dept Internal Med, Div Gastroenterol & Hepatol, Seoul, South Korea | Nam, Seung-Joo/AAD-2495-2022; Park, Junseok/ABS-0095-2022; LIM, Yun Jeong/KVY-6446-2024 | 56310341800; 56501161800; 42361607200; 36647886100; 7402311392; 57201131480; 7202215162 | drlimyj@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.77 | 2025-06-25 | 25 | 26 | 3-DIMENSIONAL IMAGE-RECONSTRUCTION; RETENTION RATES; LIMITATIONS; COMPLETION; DIAGNOSIS | Abdominal Pain; Adolescent; Adult; Aged; Aged, 80 and over; Capsule Endoscopy; Crohn Disease; Equipment Design; Feasibility Studies; Female; Gastrointestinal Hemorrhage; Humans; Imaging, Three-Dimensional; Intestinal Neoplasms; Intestine, Small; Male; Middle Aged; Prospective Studies; Software; Young Adult; abdominal pain; adolescent; adult; aged; capsule endoscopy; Crohn disease; devices; equipment design; feasibility study; female; gastrointestinal hemorrhage; human; intestine tumor; male; middle aged; pathology; prospective study; small intestine; software; three-dimensional imaging; very elderly; young adult | English | 2020 | 2020-04-07 | 10.1038/s41598-020-62935-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | 3′-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models | 3 ' -Sialyllactose (3 ' -SL), a natural prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. Although regulatory T cells (Tregs) prevent excessive inflammation and maintain immune tolerance, the effect of 3 ' -SL on Treg regulation is unclear. This study aimed to investigate the effect of 3 ' -SL on Treg responses in atopic dermatitis (AD) pathogenesis. Oral administration of 3 ' -SL reduced AD-like symptoms such as ear, epidermal, and dermal thickness in repeated topical application of house dust mites (HDM) and 2,4-dinitrochlorobenzene (DNCB). 3 ' -SL inhibited IgE, IL-1 beta, IL-6, and TNF-alpha secretion and markedly downregulated AD-related cytokines including IL-4, IL-5, IL-6, IL-13, IL-17, IFN-gamma, TNF-alpha, and Tslp through regulation of NF-kappa B in ear tissue. Additionally, in vitro assessment of Treg differentiation revealed that 3 ' -SL directly induced TGF-beta -mediated Treg differentiation. Furthermore, 3 ' -SL administration also ameliorated sensitization and elicitation of AD pathogenesis by suppressing mast cell infiltration and production of IgE and pro-inflammatory cytokines in mouse serum by mediating the Treg response. Furthermore, Bifidobacterium population was also increased by 3 ' -SL administration as prebiotics. Our data collectively show that 3 ' -SL has therapeutic effects against AD progression by inducing Treg differentiation, downregulating AD-related cytokines, and increasing the Bifidobacterium population. | Kang, Li-Jung; Oh, Eunjeong; Cho, Chanmi; Kwon, HoKeun; Lee, Choong-Gu; Jeon, Jimin; Lee, Hyemi; Choi, Sangil; Han, Seong Jae; Nam, Jiho; Song, Chi-une; Jung, Hyunho; Kim, Hye Young; Park, Eun-Jung; Choi, Eun-Ju; Kim, Jooyoung; Eyun, Seong-il; Yang, Siyoung | Ajou Univ, Dept Biomed Sci, Grad Sch Med, Suwon 16499, South Korea; Ajou Univ, Dept Pharmacol, Sch Med, Suwon 16499, South Korea; Sungkyunkwan Univ, CIRNO, Suwon 16419, South Korea; Yonsei Univ, Dept Microbiol & Immunol, Coll Med, Seoul 03722, South Korea; Korea Inst Sci & Technol KIST, Gangneung Inst Nat Prod, Gangwon Do 25451, South Korea; Chung Ang Univ, Dept Life Sci, Seoul 06974, South Korea; Synovizen Inc, Seoul 06621, South Korea; Seoul Natl Univ, Dept Biomed Sci, Lab Mucosal Immunol, Coll Med, Seoul 03080, South Korea; Kyung Hee Univ, East West Med Res Inst, Med Sci Res Inst, Seoul 02447, South Korea; Daegu Catholic Univ, Coll Educ, Dept Phys Educ, Gyongsan 38430, South Korea; Kyungpook Natl Univ, Sch Med, Dept Anat, Daegu, South Korea | Eyun, Seong-il/Q-8872-2019; Choi, Eunju/IUO-8098-2023; Lee, Choong-Gu/H-1878-2011; Kim, Hye/AAF-7609-2020; Park, Eun-Jung/Y-4427-2019 | 57195295378; 57211722612; 57195285626; 36016954100; 35196209000; 48261217800; 57210157207; 57210165437; 57210145631; 57210153201; 57211640745; 57215970179; 55676285000; 56912718000; 8443596300; 55720240400; 16309600000; 14822763000 | hirase1125@hanmail.net;eyun@cau.ac.kr;yangsy@ajou.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.91 | 2025-06-25 | 33 | 36 | THYMIC STROMAL LYMPHOPOIETIN; NF-KAPPA-B; MAST-CELLS; MECHANISMS; RESPONSES; IGE | Animals; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oligosaccharides; Prebiotics; Skin; T-Lymphocytes, Regulatory; 3'-sialyllactose; cytokine; oligosaccharide; prebiotic agent; animal; atopic dermatitis; Bagg albino mouse; C57BL mouse; disease model; drug effect; male; metabolism; mouse; regulatory T lymphocyte; skin | English | 2020 | 2020-03-27 | 10.1038/s41598-020-62527-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Abnormal cortical thickening and thinning in idiopathic normal-pressure hydrocephalus | We investigated differences in cortical thickness between idiopathic normal-pressure hydrocephalus (INPH) patients and healthy controls. We also explored whether a relationship exists between cortical thinning and gait disturbance in INPH patients. Forty-nine INPH patients and 26 healthy controls were imaged with MRI, including 3-dimensional volumetric images, for automated surface-based cortical thickness analysis across the entire brain. Compared with age- and gender-matched healthy controls, unexpectedly, INPH patients showed statistically significant cortical thickening mainly in areas located in the high convexity of the frontal, parietal, and occipital regions. Additionally, cortical thinning mainly in temporal and orbitofrontal regions was observed in the INPH group relative to the control group. The Gait Status Scale (GSS) scores were negatively correlated with cortical thickness in the medial orbital part of the superior frontal gyrus, gyrus rectus, superior temporal gyrus, temporal pole, and insula. A distinctive pattern of cortical thickness changes was found in INPH patients. We cautiously suggest that cortical thickening in INPH can result from reactive gliosis. Further, our results support the hypothesis that cortical thinning in INPH can result from neuronal degeneration. In addition, cortical thinning can play an important role in gait disturbances in INPH patients. | Kang, Kyunghun; Han, Jaehwan; Lee, Sang-Woo; Jeong, Shin Young; Lim, Yong-Hyun; Lee, Jong-Min; Yoon, Uicheul | Hanyang Univ, Dept Biomed Engn, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Daegu Catholic Univ, Dept Biomed Engn, Gyongsan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Ctr Self Organizing Software Platform, Daegu, South Korea | lee, sangwoo/KUD-1906-2024; Yoon, Uicheul/AFG-0112-2022 | 55365592200; 57211638640; 57196249819; 36164032500; 57202416711; 25622544900; 7003570756 | ljm@hanyang.ac.kr;yoonuc@cu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.41 | 2025-06-25 | 17 | 15 | AUTOMATED 3-D EXTRACTION; REACTIVE GLIOSIS; THICKNESS; GAIT; PATHOGENESIS; IMPAIRMENT; BIOMARKERS; SURFACES; INNER; MRI | Aged; Case-Control Studies; Cerebral Cortex; Female; Humans; Hydrocephalus, Normal Pressure; Magnetic Resonance Imaging; Male; Middle Aged; aged; brain cortex; case control study; female; human; male; middle aged; normotensive hydrocephalus; nuclear magnetic resonance imaging; pathology; procedures | English | 2020 | 2020-12-03 | 10.1038/s41598-020-78067-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Adverse impact of renin-angiotensin system blockade on the clinical course in hospitalized patients with severe COVID-19: a retrospective cohort study | The association between angiotensin-converting enzyme inhibitor (ACE-I) or angiotensin II receptor blocker (ARB) and the risk of mortality in hospitalized patients with severe coronavirus disease 2019 (COVID-19) was investigated. This retrospective cohort study was performed in all hospitalized patients with COVID-19 in tertiary hospitals in Daegu, Korea. Patients were classified based on whether they received ACE-I or ARB before COVID-19 diagnosis. The analysis of the primary outcome, in-hospital mortality, was performed using the Cox proportional hazards regression model. Of 130 patients with COVID-19, 30 (23.1%) who received ACE-I or ARB exhibited an increased risk of in-hospital mortality (adjusted hazard ratio, 2.20; 95% confidence interval [CI], 1.10-4.38; P=0.025). ACE-I or ARB was also associated with severe complications, such as acute respiratory distress syndrome (ARDS) (adjusted odds ratio [aOR], 2.58; 95% CI, 1.02-6.51; P=0.045) and acute kidney injury (AKI) (aOR, 3.06; 95% CI, 1.15-8.15; P=0.026). Among the patients with ACE-I or ARB therapy, 8 patients (26.7%) used high equivalent doses of ACE-I or ARB and they had higher in-hospital mortality and an increased risk of ARDS and AKI (all, P<0.05). ACE-I or ARB therapy in patients with severe COVID-19 was associated with the occurrence of severe complications and increased in-hospital mortality. The potentially harmful effect of ACE-I or ARB therapy may be higher in patients who received high doses. | Lim, Jeong-Hoon; Cho, Jang-Hee; Jeon, Yena; Kim, Ji Hye; Lee, Ga Young; Jeon, Soojee; Noh, Hee Won; Lee, Yong-Hoon; Lee, Jaehee; Chang, Hyun-Ha; Jung, Hee-Yeon; Choi, Ji-Young; Park, Sun-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Kim, Shin-Woo | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Nephrol, Dongdeok Ro 130, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Div Pulmonol & Crit Care Med, Dept Internal Med,Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Div Infect Dis, Dept Internal Med,Sch Med, Daegu, South Korea | Lee, Jaehee/S-1697-2018; Kim, Yong-Lim/AGK-3172-2022; Lim, Jeong-Hoon/ABE-6003-2020; Park, Sun-Hee/LMN-0033-2024; Lee, Jun Young/CAI-2335-2022; Lee, Seung Eun/ABG-1607-2021; Cho, Jang-hee/ABD-3534-2020 | 55360244300; 7403536291; 57209909350; 59643141000; 57219960739; 57219960429; 57219963219; 57199022948; 13805476000; 7407521688; 57196396467; 7501393222; 7501831741; 8558530700; 55633533600; 57189703358 | ksw2kms@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.77 | 2025-06-25 | 16 | 19 | CORONAVIRUS DISEASE 2019; CONVERTING ENZYME-2; ACE2; RISK; MORTALITY; LOSARTAN; RECEPTOR; OUTCOMES | Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; COVID-19; Female; Hospital Mortality; Host-Pathogen Interactions; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Pandemics; Renin-Angiotensin System; Republic of Korea; Retrospective Studies; SARS-CoV-2; Severity of Illness Index; Tertiary Care Centers; angiotensin receptor antagonist; dipeptidyl carboxypeptidase inhibitor; aged; drug effect; drug therapy; epidemiology; female; hospital mortality; host pathogen interaction; human; Kaplan Meier method; male; middle aged; pandemic; physiology; renin angiotensin aldosterone system; retrospective study; severity of illness index; South Korea; tertiary care center; virology | English | 2020 | 2020-11-20 | 10.1038/s41598-020-76915-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | An autosomal dominant ERLIN2 mutation leads to a pure HSP phenotype distinct from the autosomal recessive ERLIN2 mutations (SPG18) | Hereditary spastic paraplegia (HSP) is a heterogeneous inherited disorder that manifests with lower extremity weakness and spasticity. HSP can be inherited by autosomal dominant, autosomal recessive, and X-linked inheritance patterns. Recent studies have shown that, although rare, mutations in a single gene can lead to multiple patterns of inheritance of HSP. We enrolled the HSP family showing autosomal dominant inheritance and performed genetic study to find the cause of phenotype in this family. We recruited five members of a Korean family as study participants. Four of the five family members had pure HSP. Part of the family members underwent whole-exome sequencing (WES) to identify the causative mutation. As the result of WES and Sanger sequencing analysis, a novel missense mutation (c.452 C > T, p.Ala151Val) of ERLIN2 gene was identified as the cause of the autosomal dominant HSP in the family. Our study suggests that the ERLIN2 gene leads to both autosomal recessive and autosomal dominant patterns of inheritance in HSP. Moreover, autosomal dominant HSP caused by ERLIN2 appears to cause pure HSP in contrast to autosomal recessive ERLIN2 related complicated HSP (SPG18). | Park, Jin-Mo; Lee, Byeonghyeon; Kim, Jong-Heun; Park, Seong-Yong; Yu, Jinhoon; Kim, Un-Kyung; Park, Jin-Sung | Dongguk Univ, Coll Med, Gyeongju Hosp, Dept Neurol, Gyeongju, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu, South Korea; Kyungpook Natl Univ, Plus KNU Creat BioRes Grp BK21, Sch Life Sci, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Neurol, Sch Med, Daegu, South Korea | Park, Seong Yong/IZQ-1385-2023 | 55569003000; 56384026400; 57210338134; 57215060790; 57215046895; 7102248968; 44061744500 | kimuk@knu.ac.kr;neurojspark@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.32 | 2025-06-25 | 14 | 14 | Aged; Exome; Female; Gait Disorders, Neurologic; Genes, Dominant; Genes, Recessive; Humans; Magnetic Resonance Imaging; Male; Membrane Proteins; Middle Aged; Motor Neuron Disease; Mutation; Mutation, Missense; Pedigree; Phenotype; Republic of Korea; Sequence Analysis, DNA; Spastic Paraplegia, Hereditary; Whole Exome Sequencing; ERLIN2 protein, human; membrane protein; aged; DNA sequence; dominant gene; exome; female; genetics; hereditary motor sensory neuropathy; human; male; middle aged; missense mutation; motor neuron disease; mutation; neurologic gait disorder; nuclear magnetic resonance imaging; pedigree; phenotype; recessive gene; South Korea; whole exome sequencing | English | 2020 | 2020-02-24 | 10.1038/s41598-020-60374-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Antarctic ice mass variations from 1979 to 2017 driven by anomalous precipitation accumulation | Antarctic ice mass balance is determined by precipitation and ice discharge, and understanding their relative contributions to contemporary Antarctic ice mass change is important to project future ice mass loss and resulting sea level rise. There has been evidence that anomalous precipitation affects Antarctic ice mass loss estimates, and thus the precipitation contribution should be understood and considered in future projections. In this study, we revisit changes in Antarctic ice mass over recent decades and examine precipitation contributions over this period. We show that accumulated (time-integrated) precipitation explains most inter-annual anomalies of Antarctic ice mass change during the GRACE period (2003-2017). From 1979 to 2017, accumulated Antarctic precipitation contributes to significant ice mass loss acceleration in the Pacific sector and deceleration in the Atlantic-Indian Sectors, forming a bi-polar spatial pattern. Principal component analysis reveals that such a bi-polar pattern is likely modulated by the Southern Annular Mode (SAM). We also find that recent ice mass loss acceleration in 2007 is related to a variation in precipitation accumulation. Overall ice discharge has accelerated at a steady rate since 1992, but has not seen a recent abrupt increase. | Kim, Byeong-Hoon; Seo, Ki-Weon; Eom, Jooyoung; Chen, Jianli; Wilson, Clark R. | Korea Polar Res Inst, Div Glacial Environm Res, Incheon 21190, South Korea; Seoul Natl Univ, Dept Earth Sci Educ, Seoul 08826, South Korea; Kyungpook Natl Univ, Dept Earth Sci Educ, Daegu 41556, South Korea; Univ Texas Austin, Ctr Space Res, Austin, TX 78759 USA; Univ Texas Austin, Jackson Sch Geosci, Dept Geol Sci, Austin, TX 78712 USA | ; Kim, Byeong-Hoon/LMO-9465-2024; Chen, Jianli/KUD-8259-2024; Eom, Jooyoung/KBC-4439-2024; Seo, Ki-weon/AAH-7729-2021 | 56642186400; 8407160800; 36645970800; 57205523218; 7404896041 | seokiweon@snu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.41 | 2025-06-25 | 22 | 19 | ACCELERATION; BALANCE; TRENDS | Antarctica; article; body weight; deceleration; precipitation; principal component analysis | English | 2020 | 2020-11-23 | 10.1038/s41598-020-77403-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Asymmetric impact of Central Pacific ENSO on the reduction of tropical cyclone genesis frequency over the western North Pacific since the late 1990s | Tropical cyclone (TC) genesis frequency over the western North Pacific (WNP) is significantly reduced since the late 1990s, coinciding with a Pacific decadal oscillation (PDO) phase transition from positive to negative. In this study, the underlying mechanism for this change is investigated through analysis of asymmetric central Pacific (CP) El Nino-Southern Oscillation (ENSO) properties induced by the negative PDO phase. Our results suggest that the significant reduction is caused by asymmetric CP ENSO properties, in which the CP La Nina is more frequent than the CP El Nino during negative PDO phases; furthermore, stronger CP La Nina occurs during a negative PDO phase than during a positive PDO phase. CP La Nina (El Nino) events generate an anticyclonic (cyclonic) Rossby wave response over the eastern WNP, leading to a significant decrease (increase) in eastern WNP TC genesis. Therefore, more frequent CP La Nina events and the less frequent CP El Nino events reduce the eastern WNP mean TC genesis frequency during a negative PDO phase. In addition, stronger CP La Nina events during a negative PDO phase reinforce the reduction in eastern WNP TC genesis. The dependency of CP ENSO properties on the PDO phase is confirmed using a long-term climate model simulation, which supports our observational results. Our results will also improve understanding of TC in other basins, since both PDO and CP ENSO variability influence global dynamics. | Kim, Han-Kyoung; Seo, Kyong-Hwan; Yeh, Sang-Wook; Kang, Nam-Young; Moon, Byung-Kwon | Jeonbuk Natl Univ, Inst Fus Sci, Div Sci Educ, Jeonju, South Korea; Pusan Natl Univ, Dept Atmospher Sci, Div Earth Environm Syst, Busan, South Korea; Hanyang Univ, ERICA, Marine Sci & Convergent Technol, Ansan, South Korea; Korea Meteorol Adm, Natl Typhoon Ctr, Jeju, South Korea; Kyungpook Natl Univ, Coll Social Sci, Dept Geog, Daegu, South Korea | Yeh, Sang-Wook/G-3007-2014; Seo, Kyong-Hwan/GSD-2629-2022; yeh, sang-wook/G-3007-2014 | 57201799129; 7201839229; 7402085600; 54580993100; 7101878692 | moonbk@jbnu.ac.kr; | CLIMATE DYNAMICS | CLIM DYNAM | 0930-7575 | 1432-0894 | 54 | 1-2 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2020 | 4.375 | 22.9 | 1.73 | 2025-06-25 | 40 | 38 | Tropical cyclone; Pacific decadal oscillation; Central Pacific El Nino-Southern oscillation | DECADAL OSCILLATION; MODULATION; EVENTS; TRACKS | Central Pacific El Niño-Southern oscillation; Pacific decadal oscillation; Tropical cyclone | Pacific Ocean; Pacific Ocean (North); asymmetry; cyclogenesis; El Nino-Southern Oscillation; Pacific Decadal Oscillation; phase transition; Rossby wave; tropical cyclone | English | 2020 | 2020-01 | 10.1007/s00382-019-05020-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Atrogin1-induced loss of aquaporin 4 in myocytes leads to skeletal muscle atrophy | The water channel aquaporin 4 (AQP4) regulates the flux of water across the cell membrane, maintaining cellular homeostasis. Since AQP4 is enriched in the sarcolemma of skeletal muscle, a functional defect in AQP4 may cause skeletal muscle dysfunction. To investigate a novel mechanism underlying skeletal muscle atrophy, we examined AQP4 expression and its regulation in muscle using the rotator cuff tear (RCT) model. Human and mouse AQP4 expression was significantly decreased in atrophied muscle resulting from RCT. The size and the number of myotubes were reduced following AQP4 knockdown. Atrogin 1-mediated ubiquitination of AQP4 was verified with an ubiquitination assay after immunoprecipitation of AQP4 with an anti-AQP4 antibody. In this study, we identified high mobility group box 1 (HMGB1) as a potent upstream regulator of atrogin 1 expression. Atrogin 1 expression was increased by recombinant mouse HMGB1 protein, and the HMGB1-induced atrogin 1 expression was mediated via NF-kappa B signaling. Our study suggests that loss of AQP4 appears to be involved in myocyte shrinkage after RCT, and its degradation is mediated by atrogin 1-dependent ubiquitination. HMGB1, in its function as a signaling molecule upstream of the ubiquitin ligase atrogin 1, was found to be a novel regulator of muscle atrophy. | Chung, Seok Won; Kim, Ja-Yeon; Yoon, Jong Pil; Suh, Dong Won; Yeo, Woo Jin; Lee, Yong-Soo | Konkuk Univ, Res Inst Med Sci, Dept Orthoped Surg, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Orthoped Surg, Daegu, South Korea; Barunsesang Hosp, Joint Ctr, 75-5 Yatap Ro, Seongnam Si 13497, Gyeonggi Do, South Korea | ; Lee, Yongsoo/KFT-0716-2024 | 37065938600; 57192382942; 36098548400; 57212630130; 57218618852; 57203798727 | hrcyslee@yahoo.co.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.41 | 2025-06-25 | 17 | 16 | ROTATOR CUFF TEARS; MOLECULAR-MECHANISMS; FATTY INFILTRATION; WATER CHANNELS; UP-REGULATION; PROTEIN; EXPRESSION; IDENTIFICATION; LOCALIZATION; MURF1 | Adult; Animals; Aquaporin 4; Female; HMGB1 Protein; Humans; Male; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; NF-kappa B; Signal Transduction; SKP Cullin F-Box Protein Ligases; Tripartite Motif Proteins; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination; aquaporin 4; Fbxo32 protein, mouse; high mobility group B1 protein; immunoglobulin enhancer binding protein; muscle protein; tripartite motif protein; ubiquitin; ubiquitin protein ligase; adult; animal; C57BL mouse; female; human; male; metabolism; mouse; muscle atrophy; pathology; physiology; signal transduction; skeletal muscle; skeletal muscle cell; ubiquitination | English | 2020 | 2020-08-25 | 10.1038/s41598-020-71167-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Erratum | Author Correction: CD200R/Foxp3-mediated signalling regulates microglial activation (Scientific Reports, (2016), 6, 1, (34901), 10.1038/srep34901) | This Article contains errors in both the PDF and HTML versions. An affiliation was omitted for Jwa-Jin Kim. The correct affiliations for Jwa-Jin Kim are listed below: Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 301-747, Republic of Korea. LES Corporation Inc., Gung-Dong 465-16, Yuseong-Gu Daejeon, 305-335, Republic of Korea. In addition, in Figure 1, panel A-g is a duplicate of panel A-e. The correct panel A-g appears below. © 2020, The Author(s). | Yi, Min-Hee; Zhang, Enji; Kim, Jwa-Jin; Baek, Hyunjung; Shin, Nara; Kim, Sena; Kim, Sang Ryong; Kim, Hang-Rae; Lee, Sung Joong; Park, Jin Bong; Kim, Yonghyun; Kwon, O-Yu; Lee, Young Ho; Oh, Sang-Ha; Kim, Dong Woon | Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 301-747, South Korea, Department of Neuroscience & Cell Biology, the University of Texas Medical Branch School of Medicine, Galveston, 77555, TX, United States; Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 301-747, South Korea, Department of Anesthesiology, Yanbian University Hospital, Yanbian, 133000, China; Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 301-747, South Korea, LES Corporation Inc., Gung-Dong 465-16, Yuseong-Gu Daejeon, 305-335, South Korea; Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 301-747, South Korea; Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 301-747, South Korea; Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 301-747, South Korea, Department of Plastic Surgery, Chungnam National University Hospital, Daejeon, 301-721, South Korea; School of Life Sciences, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, South Korea; Department of Anatomy and Cell Biology, and Biomedical Sciences Seoul National University College of Medicine, Seoul, 03080, South Korea; Department of Neuroscience and Physiology, and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 110-749, South Korea; Department of Physiology, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 301-747, South Korea; Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL, United States; Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 301-747, South Korea; Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 301-747, South Korea; Department of Plastic Surgery, Chungnam National University Hospital, Daejeon, 301-721, South Korea; Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 301-747, South Korea, Department of Medical Science, Chungnam National University School of Medicine, Daejeon, 301-747, South Korea | 55376066200; 55375517300; 53865126800; 57220703194; 56699607100; 57202511667; 56486163800; 7410131447; 57840039400; 57265760800; 56080532000; 55497484800; 57281762100; 35273279100; 57204150578 | visnu528@cnu.ac.kr; | Scientific Reports | SCI REP-UK | 2045-2322 | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0 | 2025-06-25 | 0 | erratum | English | Final | 2020 | 10.1038/s41598-020-62310-6 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Automated rotator cuff tear classification using 3D convolutional neural network | Rotator cuff tear (RCT) is one of the most common shoulder injuries. When diagnosing RCT, skilled orthopedists visually interpret magnetic resonance imaging (MRI) scan data. For automated and accurate diagnosis of RCT, we propose a full 3D convolutional neural network (CNN) based method using deep learning. This 3D CNN automatically diagnoses the presence or absence of an RCT, classifies the tear size, and provides 3D visualization of the tear location. To train the 3D CNN, the Voxception-ResNet (VRN) structure was used. This architecture uses 3D convolution filters, so it is advantageous in extracting information from 3D data compared with 2D-based CNNs or traditional diagnosis methods. MRI data from 2,124 patients were used to train and test the VRN-based 3D CNN. The network is trained to classify RCT into five classes (None, Partial, Small, Medium, Large-to-Massive). A 3D class activation map (CAM) was visualized by volume rendering to show the localization and size information of RCT in 3D. A comparative experiment was performed for the proposed method and clinical experts by using randomly selected 200 test set data, which had been separated from training set. The VRN-based 3D CNN outperformed orthopedists specialized in shoulder and general orthopedists in binary accuracy (92.5% vs. 76.4% and 68.2%), top-1 accuracy (69.0% vs. 45.8% and 30.5%), top-1 +/- 1 accuracy (87.5% vs. 79.8% and 71.0%), sensitivity (0.94 vs. 0.86 and 0.90), and specificity (0.90 vs. 0.58 and 0.29). The generated 3D CAM provided effective information regarding the 3D location and size of the tear. Given these results, the proposed method demonstrates the feasibility of artificial intelligence that can assist in clinical RCT diagnosis.Y | Shim, Eungjune; Kim, Joon Yub; Yoon, Jong Pil; Ki, Se-Young; Lho, Taewoo; Kim, Youngjun; Chung, Seok Won | Korea Inst Sci & Technol, Ctr Bion, Seoul 02792, South Korea; Yeson Hosp, Dept Orthoped Surg, Bucheon 14555, South Korea; Kyungpook Natl Univ, Sch Med, Dept Orthopaed Surg, Daegu 41944, South Korea; Konkuk Univ, Dept Orthopaed Surg, Ctr Shoulder & Elbow Surg, Sch Med, Seoul 143729, South Korea | 57195289654; 57219148839; 36098548400; 57191984084; 57219146100; 57211346021; 37065938600 | junekim@kist.re.kr;smilecsw@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0.95 | 2025-06-25 | 43 | 50 | CANCER | Artificial Intelligence; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Neural Networks, Computer; Rotator Cuff Injuries; Software; artificial intelligence; classification; human; nuclear magnetic resonance imaging; pathology; procedures; rotator cuff injury; software; three-dimensional imaging | English | 2020 | 2020-09-24 | 10.1038/s41598-020-72357-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Correction | B-cell translocation gene 2 enhances fibroblast growth factor 21 production by inducing Kruppel-like factor 15 (vol 9, 3730, 2019) | Kim, Yong Deuk; Hwang, Seung-Lark; jeon, Hwang-Ju; Jeon, Yong Hyun; Nedumaran, Balachandar; Kim, Kyeongsoon; Lee, Sung-Eun | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Korea Bio Sci Co, Daegu 41520, South Korea | Jeon, Hwangju/JDW-9035-2023; Jeon, Yong/N-6910-2019 | 55549957700; 12446620600; 56328792200; 16042453400; 23976497500; 57192873520; 55890041600 | ydkim94@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 10 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 4.38 | 22.9 | 0 | 2025-06-25 | 0 | 0 | erratum | English | 2020 | 2020-02-13 | 10.1038/s41598-020-59784-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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