연구성과로 돌아가기
2020 연구성과 (87 / 270)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Review | Therapeutic Effect of Seaweed Derived Xanthophyl Carotenoid on Obesity Management; Overview of the Last Decade | Present-day lifestyles associated with high calorie-fat intake and accumulation, as well as energy imbalance, have led to the development of obesity and its comorbidities, which have emerged as some of the major health issues globally. To combat the disease, many studies have reported the anti-obesity effects of natural compounds in foods, with some advantages over chemical treatments. Carotenoids, such as xanthophyll derived from seaweeds, have attracted the attention of researchers due to their notable biological activities, which are associated mainly with their antioxidant properties. Their involvement in oxidative stress modulation, the regulation of major transcription factors and enzymes, and their antagonistic effects on various obesity parameters have been examined in both in vitro and in vivo studies. The present review is a collation of published research over the last decade on the antioxidant properties of seaweed xanthophyll carotenoids, with a focus on fucoxanthin and astaxanthin and their mechanisms of action in obesity prevention and treatment. | Ojulari, Oyindamola Vivian; Lee, Seul Gi; Nam, Ju-Ock | Kyungpook Natl Univ, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea | 57205371298; 56995397800; 7201496105 | hoyeendahmolar@gmail.com;lsg100479@naver.com;namjo@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 7 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.52 | 2025-06-25 | 19 | 26 | carotenoids; seaweeds; antioxidants; astaxanthin; fucoxanthin; anti-obesity; oxidative stress | CARBON-DIOXIDE EXTRACTION; IMPROVES LIPID-METABOLISM; DIET-INDUCED OBESITY; FATTY LIVER-DISEASE; BODY-WEIGHT GAIN; OXIDATIVE STRESS; ANTIOXIDANT PROPERTIES; INSULIN-RESISTANCE; ADIPOSE-TISSUE; HAEMATOCOCCUS-PLUVIALIS | Anti-obesity; Antioxidants; Astaxanthin; Carotenoids; Fucoxanthin; Oxidative stress; Seaweeds | Animals; Gene Expression Regulation; Humans; Obesity; Obesity Management; Oxidative Stress; Seaweed; Signal Transduction; Xanthophylls; astaxanthin; carotenoid; fucoxanthin; xanthophyll; xanthophyll; adipocyte; adipogenesis; antioxidant activity; bioavailability; body weight gain; body weight loss; caloric intake; diet supplementation; fatty acid oxidation; food intake; gene expression; human; insulin sensitivity; lipid metabolism; lipid peroxidation; nonhuman; obesity; obesity management; oxidative stress; protein expression; Review; seaweed; signal transduction; upregulation; animal; chemistry; drug effect; gene expression regulation; metabolism; obesity; seaweed | English | 2020 | 2020-04 | 10.3390/ijms21072502 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Therapeutic Potential of Tauroursodeoxycholic Acid for the Treatment of Osteoporosis | Tauroursodeoxycholic acid (TUDCA) is a US FDA-approved hydrophilic bile acid for the treatment of chronic cholestatic liver disease. In the present study, we investigate the effects of TUDCA on the proliferation and differentiation of osteoblasts and its therapeutic effect on a mice model of osteoporosis. Following treatment with different concentrations of TUDCA, cell viability, differentiation, and mineralization were measured. Three-month-old female C57BL/6 mice were randomly divided into three groups (n= 8 mice per group): (i) normal mice as the control group, (ii) ovariectomy (OVX) group (receiving phosphate-buffered saline (PBS) treatment every other day for 4 weeks), and (iii) OVX group with TUDCA (receiving TUDCA treatment every other day for 4 weeks starting 6 weeks after OVX). At 11 weeks post-surgery, serum levels of procollagen type I N-terminal propeptides (PINP) and type I collagen crosslinked C-telopeptides (CTX) were measured, and all mice were sacrificed to examine the distal femur by micro-computed tomography (CT) scans and histology. TUDCA (100 nM, 1 mu M) significantly increased the proliferation and viability of osteoblasts and osteoblast differentiation and mineralization when used in vitro. Furthermore, TUDCA neutralized the detrimental effects of methylprednisolone (methylprednisolone-induced osteoblast apoptosis). In the TUDCA treatment group the PINP level was higher and the CTX level was lower, but these levels were not significantly different compared to the PBS treatment group. Micro-CT and histology showed that the TUDCA treatment group preserved more trabecular structures in the distal femur compared to the PBS treatment group. In addition, the TUDCA treatment group increased the percentage bone volume with respect to the total bone volume, bone mineral density, and mice distal femur trabeculae compared with the PBS treatment group. Taken together, our findings suggest that TUDCA may provide a favorable effect on bones and could be used for the prevention and treatment of osteoporosis. | Ahn, Tae-Keun; Kim, Kyoung-Tae; Joshi, Hari Prasad; Park, Kwang Hwan; Kyung, Jae Won; Choi, Un-Yong; Sohn, Seil; Sheen, Seung-Hun; Shin, Dong-Eun; Lee, Soo-Hong; Han, In-Bo | CHA Univ, CHA Bundang Med Ctr, Dept Orthoped Surg, Sch Med, Seongnam Si 13496, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Neurosurg, Daegu 41944, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Neurosurg, Sch Med, Seongnam Si 13496, Gyeonggi Do, South Korea; Yonsei Univ, Severance Hosp, Dept Orthoped Surg, Seoul 03772, South Korea; Dongguk Univ Seoul, Dept Med Biotechnol, Seoul 04620, South Korea | ; Lee, Jee-Yon/GER-4141-2022 | 56540832500; 57201369790; 57201974279; 55905951000; 56895826800; 57209540640; 55047974500; 57523864600; 8315617000; 56083752300; 9338449900 | ajh329@gmail.com;nskimkt7@gmail.com;hariprasadjoshi10@gmail.com;khpark800@gmail.com;kyungjaewon88@gmail.com;nschoiuy@gmail.com;sisohn@hanmail.net;nssheen@cha.ac.kr;shinde@cha.ac.kr;soohong@dongguk.edu;hanib@cha.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 1.01 | 2025-06-25 | 26 | 23 | osteoblast; osteoporosis; bone turnover biomarkers; matrix mineralization; bone histomorphometry | BILE-ACID; DIFFERENTIATION; STRESS; MODEL | Bone histomorphometry; Bone turnover biomarkers; Matrix mineralization; Osteoblast; Osteoporosis | Animals; Cell Differentiation; Cell Survival; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Methylprednisolone; Mice; Osteoblasts; Osteoporosis; Ovariectomy; Peptide Fragments; Procollagen; Random Allocation; Taurochenodeoxycholic Acid; Treatment Outcome; alkaline phosphatase; carboxy terminal telopeptide; cholecystokinin octapeptide; methylprednisolone; osteoclast differentiation factor; phosphate buffered saline; procollagen C proteinase; tauroursodeoxycholic acid; transcription factor RUNX2; methylprednisolone; peptide fragment; procollagen; procollagen Type I N-terminal peptide; taurochenodeoxycholic acid; taurursodiol; animal cell; animal model; animal tissue; apoptosis; Article; bone density; bone metabolism; bone volume; C57BL 6 mouse; cell differentiation; cell proliferation; cell viability; computer assisted tomography; controlled study; enzyme activity; enzyme immunoassay; enzyme linked immunosorbent assay; female; male; morphometry; mouse; MTT assay; nonhuman; osteoblast; osteoclastogenesis; osteoporosis; ovariectomy; protein expression; real time polymerase chain reaction; therapy effect; trabecular bone; adverse event; animal; cell survival; cytology; disease model; drug effect; gene expression regulation; human; metabolism; osteoporosis; randomization; treatment outcome | English | 2020 | 2020-06 | 10.3390/ijms21124274 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Treatment with intravenous busulfan, melphalan, and etoposide followed by autologous stem cell transplantation in patients with non-Hodgkin's lymphoma: a multicenter study from the consortium for improving survival of lymphoma | Several high-dose therapy (HDT) conditioning regimens have been used to treat non-Hodgkin's lymphoma (NHL), such as bis-chloroethylnitrosourea (BCNU)/etoposide/cytosine arabinoside/melphalan (BEAM), BCNU/etoposide/cytosine arabinoside/cyclophosphamide (BEAC), and cyclophosphamide/BCNU/etoposide (CBV). BCNU is an active drug in HDT of NHL, but the supply is limited in some countries, including Korea. Busulfan has been used in allogeneic and autologous stem cell transplantation (ASCT). This phase II study evaluated the efficacy of busulfan/melphalan/etoposide (BuME) as a conditioning regimen for HDT in relapsed or high-risk NHL. The regimen consisted of intravenous busulfan (3.2 mg/kg/day) on days -8, -7, and -6, etoposide (400 mg/m(2)/day) on days -5 and -4, and melphalan (50 mg/m(2)/day) on days -3 and -2. A total of 46 patients were included in the study, with 36 (78.3%) achieving a complete response after ASCT. The 2-year progression-free survival (PFS) and overall survival (OS) rates for all patients were 46.7% (95% CI, 31.8-60.4%) and 63.7% (95% CI, 47.7-76.0%), respectively. There was no development of veno-occlusive disease and no treatment-related deaths within 100 days after ASCT. These results indicate that a BuME regimen is well-tolerated and effective for patients with relapsed or high-risk NHL, and may be comparable to some previously used regimens. This regimen may be useful as a substitute for BCNU-containing regimens. | Kim, Kyoung Ha; Kim, Won Seog; Kim, Seok Jin; Yoon, Dok Hyun; Suh, Cheolwon; Kang, Hye Jin; Choi, Chul Won; Lee, Ho Sup; Bae, Sung Hwa; Park, Jinny; Park, Eun Kyung; Kwak, Jae-Yong; Lee, Mark Hong; Kang, Byung Woog; Park, Sung-Kyu; Won, Jong-Ho | Soonchunhyang Univ, Soonchunhyang Univ Hosp, Dept Internal Med, Div Hematol & Oncol,Coll Med, 59 Daesagwan Ro, Seoul 04401, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Hematol Oncol,Sch Med, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Oncol, Coll Med, Seoul, South Korea; Korea Canc Ctr Hosp, Korea Inst Radiol & Med Sci, Dept Internal Med, Div Hematol Oncol, Seoul, South Korea; Korea Univ, Dept Internal Med, Div Oncol Hematol, Guro Hosp, Seoul, South Korea; Kosin Univ, Coll Med, Dept Internal Med, Div Hematol Oncol,Gospel Hosp, Busan, South Korea; Catholic Univ Daegu, Dept Internal Med, Sch Med, Daegu, South Korea; Gachon Univ, Gil Med Ctr, Div Hematol, Coll Med,Dept Internal Med, Incheon, South Korea; Chung Ang Univ, Dept Internal Med, Div Hematol Oncol, Coll Med, Seoul, South Korea; Chonbuk Natl Univ, Dept Internal Med, Div Hematol Oncol, Med Sch, Jeonju, South Korea; Konkuk Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Hematol Oncol, Med Ctr, Daegu, South Korea; Soonchunhyang Univ, Dept Internal Med, Div Hematol & Oncol, Bucheon Hosp, Bucheon Si, Gyeonggi Do, South Korea | Kim, Min/ACN-6827-2022; Won, Jongho/AAM-8322-2021; Kim, Seok-Jin/KLD-3582-2024; Liu, Jingwei/AAZ-9739-2021; Park, Jin-Young/HDN-0483-2022; Kim, Won/C-9613-2011; Juyoung, Park/LMQ-3664-2024; Hyun-Jung, Kim/E-8074-2011; Kim, Il Young/LLK-4732-2024 | 7409319096; 57977785900; 36521373300; 25959467800; 7102970953; 23497013500; 13907063000; 57218103550; 56545017400; 35277336100; 57203611952; 57204796646; 55716868500; 28567838500; 57206639759; 26434081600 | jhwon@schmc.ac.kr; | TRANSPLANT INTERNATIONAL | TRANSPL INT | 0934-0874 | 1432-2277 | 33 | 10 | SCIE | SURGERY;TRANSPLANTATION | 2020 | 3.782 | 22.5 | 0.33 | 2025-06-25 | 5 | 3 | autologous stem cell transplantation | BONE-MARROW-TRANSPLANTATION; HIGH-DOSE THERAPY; CONDITIONING REGIMEN; CYCLOPHOSPHAMIDE; CHEMOTHERAPY; CYTARABINE; BEAC; CARDIOTOXICITY; FLUDARABINE; TOXICITY | autologous stem cell transplantation | Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cyclophosphamide; Disease-Free Survival; Etoposide; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Lymphoma, Non-Hodgkin; Melphalan; Republic of Korea; Transplantation Conditioning; Transplantation, Autologous; antiinfective agent; busulfan; etoposide; filgrastim; lenograstim; melphalan; phenytoin; rituximab; antineoplastic agent; busulfan; cyclophosphamide; etoposide; melphalan; adult; Article; autologous stem cell transplantation; cancer recurrence; cancer risk; cancer survival; clinical article; controlled study; diarrhea; drug dose regimen; drug efficacy; drug megadose; drug safety; drug tolerance; female; fever; high risk patient; human; liver toxicity; lung toxicity; male; mucosa inflammation; multicenter study; nausea; nephrotoxicity; nonhodgkin lymphoma; outcome assessment; overall survival; peripheral neuropathy; phase 2 clinical trial; priority journal; progression free survival; prospective study; skin toxicity; treatment duration; treatment response; vomiting; autotransplantation; clinical trial; disease free survival; hematopoietic stem cell transplantation; lymphoma; nonhodgkin lymphoma; South Korea; transplantation conditioning | English | 2020 | 2020-10 | 10.1111/tri.13664 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain | Ras homolog protein enriched in brain (Rheb) is a key activator of mammalian target of rapamycin complex 1 (mTORC1). The activation of mTORC1 by Rheb is associated with various processes such as protein synthesis, neuronal growth, differentiation, axonal regeneration, energy homeostasis, autophagy, and amino acid uptake. In addition, Rheb-mTORC1 signaling plays a crucial role in preventing the neurodegeneration of hippocampal neurons in the adult brain. Increasing evidence suggests that the constitutive activation of Rheb has beneficial effects against neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Our recent studies revealed that adeno-associated virus serotype 1 (AAV1) transduction with Rheb(S16H), a constitutively active form of Rheb, exhibits neuroprotective properties through the induction of various neurotrophic factors, promoting neurotrophic interactions between neurons and astrocytes in the hippocampus of the adult brain. This review provides compelling evidence for the therapeutic potential of AAV1-Rheb(S16H) transduction in the hippocampus of the adult brain by exploring its neuroprotective effects and mechanisms. | Moon, Gyeong Joon; Shin, Minsang; Kim, Sang Ryong | Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu 41944, South Korea | Moon, Gyeong/P-7878-2019 | 8323365700; 7401536650; 56486163800 | neobios7@gmail.com;shinms@knu.ac.kr;srk75@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.14 | 2025-06-25 | 6 | 6 | Rheb(S16H); neurotrophic interaction; neurotrophic factor; Alzheimer's disease | CILIARY NEUROTROPHIC FACTOR; CONSTITUTIVELY ACTIVE RHEB; SMALL GTPASE-RHEB; ALZHEIMERS-DISEASE; MAMMALIAN TARGET; MESSENGER-RNA; PARKINSONS-DISEASE; PROTEIN-SYNTHESIS; DOPAMINE NEURONS; DECREASED-LEVELS | Alzheimer’s disease; Neurotrophic factor; Neurotrophic interaction; Rheb(S16H) | Alzheimer Disease; Animals; Astrocytes; Brain; Hippocampus; Humans; Mechanistic Target of Rapamycin Complex 1; Nerve Growth Factors; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Parkinson Disease; Parvovirinae; Ras Homolog Enriched in Brain Protein; Signal Transduction; Up-Regulation; amyloid beta protein; brain derived neurotrophic factor; ciliary neurotrophic factor; ciliary neurotrophic factor receptor; fibroblast growth factor; glial cell line derived neurotrophic factor receptor; glycogen synthase kinase 3; guanosine triphosphatase; I kappa B; initiation factor 4E binding protein; mammalian target of rapamycin complex 1; netrin 1; neurotrophic factor; proteasome; protein kinase B; protein kinase R; protein p14; protein p18; Rheb protein; S6 kinase; transcription factor MafK; mammalian target of rapamycin complex 1; nerve growth factor; neuroprotective agent; Rheb protein; RHEB protein, human; adult; Alzheimer disease; brain protection; cell differentiation; cell survival; dopaminergic nerve cell; down regulation; gene expression; gene overexpression; hippocampus; homeostasis; inflammation; long term potentiation; lysosome membrane; MAPK signaling; mTOR signaling; nerve cell differentiation; nerve cell plasticity; nerve degeneration; nervous system development; neuroprotection; nonhuman; Pi3K/Akt signaling; protein degradation; protein expression; protein homeostasis; protein phosphorylation; regulatory mechanism; Review; signal transduction; upregulation; animal; astrocyte; brain; degenerative disease; drug effect; genetics; hippocampus; human; metabolism; nerve cell; Parkinson disease; Parvovirinae; upregulation | English | 2020 | 2020-03 | 10.3390/ijms21062023 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Vascular Calcification-New Insights into Its Mechanism | Vascular calcification (VC), which is categorized by intimal and medial calcification, depending on the site(s) involved within the vessel, is closely related to cardiovascular disease. Specifically, medial calcification is prevalent in certain medical situations, including chronic kidney disease and diabetes. The past few decades have seen extensive research into VC, revealing that the mechanism of VC is not merely a consequence of a high-phosphorous and -calcium milieu, but also occurs via delicate and well-organized biologic processes, including an imbalance between osteochondrogenic signaling and anticalcific events. In addition to traditionally established osteogenic signaling, dysfunctional calcium homeostasis is prerequisite in the development of VC. Moreover, loss of defensive mechanisms, by microorganelle dysfunction, including hyper-fragmented mitochondria, mitochondrial oxidative stress, defective autophagy or mitophagy, and endoplasmic reticulum (ER) stress, may all contribute to VC. To facilitate the understanding of vascular calcification, across any number of bioscientific disciplines, we provide this review of a detailed updated molecular mechanism of VC. This encompasses a vascular smooth muscle phenotypic of osteogenic differentiation, and multiple signaling pathways of VC induction, including the roles of inflammation and cellular microorganelle genesis. | Lee, Sun Joo; Lee, In-Kyu; Jeon, Jae-Han | Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea | ; Lee, In-Kyu/AAR-6374-2021 | 57077726900; 36071537600; 36910340400 | disjrk@dgmif.re.kr;leei@knu.ac.kr;jeonjh@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 5.6 | 2025-06-25 | 321 | 327 | autophagy; chronic kidney disease; endoplasmic reticulum; hyperphosphatemia; inflammation; matrix vesicle; mitochondrial dysfunction; osteogenic differentiation; vascular calcification; vascular smooth muscle cell | SMOOTH-MUSCLE-CELL; MATRIX GLA-PROTEIN; ENDOPLASMIC-RETICULUM STRESS; BONE MORPHOGENETIC PROTEIN-2; CHRONIC KIDNEY-DISEASE; ARTERIAL MEDIAL CALCIFICATION; TRANSCRIPTION FACTOR RUNX2; MESENCHYMAL STEM-CELLS; KAPPA-B LIGAND; FETUIN-A | Autophagy; Chronic kidney disease; Endoplasmic reticulum; Hyperphosphatemia; Inflammation; Matrix vesicle; Mitochondrial dysfunction; Osteogenic differentiation; Vascular calcification; Vascular smooth muscle cell | Animals; Autophagy; Biomarkers; Cellular Microenvironment; Disease Susceptibility; Endoplasmic Reticulum Stress; Humans; Inflammation; Mitochondria; Mitophagy; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Organ Specificity; Phosphates; Risk Factors; Vascular Calcification; apolipoprotein B; bone morphogenetic protein 2; bone morphogenetic protein receptor 2; collagen type 1; cytochrome c; glucose transporter 4; interleukin 6; microRNA; osteoclast differentiation factor; osteogenic protein 1; osteoprotegerin; parathyroid hormone; reactive oxygen metabolite; sphingomyelin phosphodiesterase; transcription factor RUNX2; tumor necrosis factor; ubiquitin protein ligase E3; valproic acid; vitamin D; biological marker; phosphate; aortic valve disease; atherogenesis; atherosclerotic plaque; blood vessel calcification; bone metabolism; calcification; cell differentiation; chronic kidney failure; chronic obstructive lung disease; coronary artery calcification; electron microscopy; end stage renal disease; endoplasmic reticulum stress; endothelial dysfunction; epithelial mesenchymal transition; human; hyperglycemia; hyperlipidemia; hyperphosphatemia; mesenchymal stem cell; non insulin dependent diabetes mellitus; nonalcoholic fatty liver; osteolysis; Review; vascular smooth muscle cell; animal; antibody specificity; autophagy; blood vessel calcification; complication; disease predisposition; inflammation; metabolism; mitochondrion; mitophagy; risk factor; smooth muscle cell; tumor microenvironment; vascular smooth muscle | English | 2020 | 2020-04 | 10.3390/ijms21082685 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Is a Local Administration of Parathyroid Hormone Effective to Tendon-to-Bone Healing in a Rat Rotator Cuff Repair Model? | To evaluate the effect of local parathyroid hormone (PTH) administration on rotator cuff tendon-to-bone healing in a rat model compared with systemic PTH injection and untreated controls. PTH-alginate scaffold was prepared and sustained release of PTH was confirmed. Bilateral supraspinatus tendon repairs were performed in 39 rats (group 1, supraspinatus repair only; group 2, supraspinatus repair with systemic PTH injection; group 3, supraspinatus repair with local PTH administration via an absorbable scaffold; n = 13 each). Biomechanical (cross-sectional area, mode of failure, load to failure, and ultimate stress: right side) and histological analyses (hematoxylin and eosin stain, Masson's Trichrome stain Picrosirius red stain, Immunohistochemistry for BMP2, PTH1R, ColI, and ColIII: Left side) were performed to evaluate tendon-to-bone healing quality at 8 weeks after repair, and blood test (osteocalcin and procollagen type I N-terminal pro-peptide [PINP] levels) was performed in all rats. There was no intergroup difference in the healing failure rate (p = 0.910) or failure mode (p = 0.585). Biomechanically, subjects in groups 2 and 3 exhibited significantly larger cross-sectional areas and higher ultimate failure loads and ultimate stress than those in group 1 (all p 0.05). Histologically, groups 2 and 3 exhibited more organized tendon-to-bone interface structures with higher density, parallel orientation, and collagen fiber continuity than group 1 (all p 0.05). The protein levels of bone morphogenic protein 2, PTH 1 receptor, and collagen I and III and the serum level of PINP were increased in groups 2 and 3 versus group 1 (all p 0.05). Local PTH administration using an absorbable scaffold improved the biomechanical and histological outcomes of rotator cuff tendon-to-bone healing comparable with systemic PTH injection at 8 weeks after repair in a rat model. (c) 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res | Yoon, Jong Pil; Chung, Seok Won; Jung, Jae Wook; Lee, Yong-Soo; Kim, Kwang-Il; Park, Ga Young; Kim, Hun-Min; Choi, Jin-Hyun | Kyung Pook Natl Univ, Coll Med, Dept Orthopaed Surg, Daegu, South Korea; Konkuk Univ, Dept Orthopaed Surg, Sch Med, 120-1 Neungdong Ro, Seoul 05030, South Korea; KyungPook Natl Univ, Coll Agr & Life Sci, Sch Med, Dept Biofibers & Mat Sci, Daegu, South Korea | Kim, Kwang-il/AAP-7315-2021; Lee, Yong-Soo/AAI-7059-2020; Kim, Sae/AAR-3907-2020 | 36098548400; 37065938600; 49061182000; 57203798727; 57211680606; 57190136627; 57210831160; 36076723600 | smilecsw@gmail.com; | JOURNAL OF ORTHOPAEDIC RESEARCH | J ORTHOP RES | 0736-0266 | 1554-527X | 38 | 1 | SCIE | ORTHOPEDICS | 2020 | 3.494 | 22.6 | 2.59 | 2025-06-25 | 26 | 27 | parathyroid hormone; local administration; systemic injection; rotator cuff; tendon-to-bone healing | PLATELET-RICH PLASMA; SUPRASPINATUS TENDON; TISSUE-REPAIR; PTH 1-34; TERIPARATIDE; ALGINATE; FRACTURE; CHONDROGENESIS; OSTEOPOROSIS; INTEGRITY | local administration; parathyroid hormone; rotator cuff; systemic injection; tendon-to-bone healing | Animals; Biomechanical Phenomena; Bone and Bones; Immunohistochemistry; Parathyroid Hormone; Peptide Fragments; Procollagen; Rats; Rats, Sprague-Dawley; Rotator Cuff; Rotator Cuff Injuries; Tendons; Wound Healing; alginic acid; bone morphogenetic protein 2; collagen type 1; collagen type 3; osteocalcin; parathyroid hormone; parathyroid hormone receptor 1; procollagen C proteinase; parathyroid hormone; peptide fragment; procollagen; procollagen Type I N-terminal peptide; animal experiment; animal model; animal tissue; Article; biomechanics; collagen fiber; controlled study; fracture healing; histopathology; immunohistochemistry; in vitro study; nonhuman; priority journal; protein blood level; rat; rotator cuff; shoulder surgery; sustained drug release; tendon; tendon reconstruction; animal; blood; bone; drug effect; pathology; pathophysiology; rotator cuff; rotator cuff injury; Sprague Dawley rat; tendon; wound healing | English | 2020 | 2020-01 | 10.1002/jor.24452 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | FGFR1 is associated with c-MYC and proangiogenic molecules in metastatic renal cell carcinoma under anti-angiogenic therapy | Aims This study aimed to investigate the clinicopathological significance of FGFR1 and c-MYC expression, particularly in relation to angiogenesis in clear cell renal cell carcinoma (CCRCC). Methods and results Immunohistochemistry and fluorescence in-situ hybridisation were conducted with tissue microarrays from 91 metastatic CCRCC patients who received VEGF receptor tyrosine kinase inhibitors (VEGFR-TKIs). The expression of angiogenic molecules, FGFR1 and c-MYC, and tumoral vascular density (TVD) and mRNA expression and TVD of 533 CCRCCs in The Cancer Genome Atlas (TCGA) were analysed. FGFR1, pFGFR1 and c-MYC expression was observed in 29.1, 74.4 and 30.8% of tumours, respectively. FGFR1(high) was an independent worse prognostic factor for overall (HR = 1.871, P = 0.032) and progression-free (HR = 1.976, P = 0.016) survival. FGFR1(high) was significantly related to VEGFR-TKI responsiveness (P = 0.011). The presence of FGFR1(high)/c-MYChigh showed a positive correlation with proangiogenic markers, including VEGF (P = 0.018) and HIF-1 alpha (P < 0.0001). FGFR1(high)/c-MYChigh tumours showed higher TVDs together with higher VEGFR2 and PDGFR-beta expression (both P < 0.0001). FGFR1 and c-MYC expression was also positively correlated with the expression of hypoxia-related and proangiogenic-related genes in the TCGA data. Conclusions FGFR1 and c-MYC may be involved in tumour angiogenesis and FGFR1 may represent a promising therapeutic target in metastatic CCRCC. | Park, Jee Young; Kim, Pil-Jong; Shin, Su-Jin; Lee, Jae-Lyun; Cho, Yong Mee; Go, Heounjeong | Kyungpook Natl Univ, Sch Med, Med Ctr, Dept Pathol, Daegu, South Korea; Seoul Natl Univ, Sch Dent, Biomed Knowledge Engn Lab, Seoul, South Korea; Dent Res Inst, Seoul, South Korea; Gangnam Severance Hosp, Dept Pathol, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea | Lee, Jae Lyun/AGI-4843-2022; Park, Jung Hwan/AAA-1951-2022; Shin, Su-Jin/KPB-2645-2024; Kim, Pil/A-5884-2013 | 57226185359; 56704209200; 57189709813; 7601475983; 57216074751; 57204538826 | damul37@amc.seoul.kr; | HISTOPATHOLOGY | HISTOPATHOLOGY | 0309-0167 | 1365-2559 | 76 | 6 | SCIE | CELL BIOLOGY;PATHOLOGY | 2020 | 5.087 | 22.7 | 0.6 | 2025-06-25 | 7 | 7 | angiogenesis; c-MYC; fibroblast growth factor receptor 1; metastatic clear cell renal cell carcinoma | GROWTH-FACTOR RECEPTOR; GENE AMPLIFICATION; TARGETED THERAPY; DOVITINIB TKI258; EXPRESSION; TUMORS; TRANSFORMATION; RESISTANCE; SURVIVAL; SYSTEM | angiogenesis; c-MYC; fibroblast growth factor receptor 1; metastatic clear cell renal cell carcinoma | Aged; Angiogenesis Inhibitors; Biomarkers, Tumor; Carcinoma, Renal Cell; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Neovascularization, Pathologic; Proto-Oncogene Proteins c-myc; Receptor, Fibroblast Growth Factor, Type 1; fibroblast growth factor 1; fibroblast growth factor 2; fibroblast growth factor 23; fibroblast growth factor receptor 1; hypoxia inducible factor 1alpha; hypoxia inducible factor 2alpha; messenger RNA; Myc protein; pazopanib; phosphoprotein; platelet derived growth factor beta receptor; platelet derived growth factor receptor; protein tyrosine kinase inhibitor; sorafenib; sunitinib; vasculotropin; vasculotropin inhibitor; vasculotropin receptor 2; angiogenesis inhibitor; FGFR1 protein, human; fibroblast growth factor receptor 1; Myc protein; MYC protein, human; tumor marker; adult; antiangiogenic therapy; Article; cancer patient; cancer prognosis; cancer specific survival; clinical feature; comparative study; controlled study; distant metastasis; female; fluorescence in situ hybridization; gene dosage; histopathology; human; immunohistochemistry; Karnofsky Performance Status; kidney metastasis; kidney vein thrombosis; major clinical study; male; median survival time; metastasis resection; middle aged; mRNA expression level; nephrectomy; oncogene c myc; overall survival; priority journal; progression free survival; protein phosphorylation; tissue microarray; tumor vascularization; aged; kidney tumor; metabolism; neovascularization (pathology); pathology; renal cell carcinoma | English | 2020 | 2020-05 | 10.1111/his.14076 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Measurement of the thermal neutron cross section and resonance integral of the ¹⁸⁷Re(n,γ)¹⁸⁸Re reaction | We measured the thermal neutron capture cross sections (sigma(0)) and resonance integral (I-0) of the Re-187(n,gamma)Re-188 reaction relative to that of the Au-197(n,gamma)Au-198 monitor reaction using neutron activation with the Cd ratio method. The investigated samples and monitors were irradiated with and without a 0.5-mm-thick Cd cover for the pulsed neutron source based on the 100-MeV electron linac at the Pohang Accelerator Laboratory (PAL). The induced activities for the reaction products were measured using a high-purity germanium (HPGe) detector. In order to improve the accuracy of the experimental results, the necessary corrections were made. The thermal neutron capture cross sections and resonance integral of the Re-187(n,gamma)Re-188 reaction were determined relative to reference values of sigma(o,Au) = 98.65 +/- 0.09 barn and I-o,I-Au = 1550 +/- 28 barn from the Au-197(n,gamma)Au-198 reaction, respectively. The corresponding values for the Re-187(n,gamma)Re-188 reaction were determined to be sigma(0,Re) = 75.6 +/- 3.4 barn and I-0,I-Re = 317 +/- 22 barn, respectively. The obtained results are compared with the literature data and discussed. | Nguyen, Thi Hien; Nguyen, Van Do; Kim, Guinyun; Kye, Yong-uk; Shin, Sung-Gyun; Cho, Moo-Hyun | Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Duy Tan Univ, Inst Theoret & Appl Res, 1 Phung Chi Kien St, Hanoi 100000, Vietnam; Vietnam Acad Sci & Technol, Inst Phys, 10 Dao Tan, Hanoi, Vietnam; Pohang Univ Sci & Technol, Dept Adv Nucl Engn, Pohang 37673, South Korea | Nguyen, Thong/ABV-0605-2022 | 57201066391; 57209329937; 35313854400; 56020858600; 55770867100; 17136702900 | gnkim@knu.ac.kr; | EUROPEAN PHYSICAL JOURNAL PLUS | EUR PHYS J PLUS | 2190-5444 | 135 | 4 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2020 | 3.911 | 22.7 | 0.15 | 2025-06-25 | 2 | 2 | SELF-SHIELDING FACTORS; NUCLEAR-DATA; RHENIUM; CAPTURE; FOILS | English | 2020 | 2020-04-29 | 10.1140/epjp/s13360-020-00406-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Production cross-sections of Mo-isotopes induced by fast neutrons based on the ⁹Be(p, n) reaction | We measured the flux-weighted average cross-sections of the(100)Mo(n, 2n)Mo-99 and(92)Mo(n, 3n)Mo-90 reactions with the average neutron energies between 14.0- and 31.8-MeV by using an activation and off-line gamma-ray spectrometric technique. The fast neutrons were generated based on the(9)Be(p,n) reaction with the proton energies of 25-, 35- and 45-MeV from the MC-50 Cyclotron at the Korea Institute of Radiological and Medical Sciences (KIRAMS). The neutron flux was measured by using the(27)Al(n,alpha)Na-24 monitor reaction, whereas the neutron spectra were simulated by using the MCNPX 2.6.0 code. The theoretical cross-sections of the(100)Mo(n, 2n)Mo-99 and(92)Mo(n,xn)Mo-91.90,Mo-89 reactions as a function of mono-energetic neutron were calculated by using the TALYS-1.9 code. The present results for the(100)Mo(n, 2n)Mo-99 and(92)Mo(n, 3n)Mo-90 reactions are compared with the calculated neutron flux-weighted average values based on the literature data and theoretical cross-sections as a function of mono-energetic neutron energy, and show a good agreement. | Naik, Haladhara; Kim, Guinyun; Kim, Kwangsoo; Nadeem, Muhammad; Sahid, Muhammad | Bhabha Atom Res Ctr, Radiochem Div, Mumbai 400085, Maharashtra, India; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea | Nadeem, Muhammad/HKV-5114-2023 | 7005890232; 35313854400; 36137214700; 56730154200; 55846094000 | gnkim@knu.ac.kr; | EUROPEAN PHYSICAL JOURNAL PLUS | EUR PHYS J PLUS | 2190-5444 | 135 | 9 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2020 | 3.911 | 22.7 | 0.15 | 2025-06-25 | 2 | 3 | EXCITATION-FUNCTIONS; NUCLEAR-REACTIONS; MO-99; ENERGY; RATIOS | English | 2020 | 2020-09-08 | 10.1140/epjp/s13360-020-00728-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Static corrective control with model matching indicator and its application to payload data managers | Having no internal states, static corrective controllers are advantageous over dynamic ones in terms of resource usage, albeit requiring stricter existence conditions. This study presents a novel static corrective control strategy that solves the model matching problem of input/state asynchronous sequential machines. Compared with the previous result, the proposed scheme provides a relaxed existence condition by utilising the model matching indicator that specifies the desirable state at hand. It is shown that the proposed static controller can be designed as long as a corresponding dynamic one exists. The improvement of resource usage in controller synthesis is validated by applying the proposed scheme to the payload data manager in the mass memory unit of satellite systems. | Yang, Jung-Min; Kwak, Seong Woo | Kyungpook Natl Univ, Sch Elect Engn, 80 Daehakro, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Control & Instrumentat Engn, 45 Yongsoro, Busan 48513, South Korea | 57208450551; 59816855300 | ksw@pknu.ac.kr; | IET CONTROL THEORY AND APPLICATIONS | IET CONTROL THEORY A | 1751-8644 | 1751-8652 | 14 | 11 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION | 2020 | 3.527 | 22.7 | 0 | 2025-06-25 | 0 | 0 | closed loop systems; control system synthesis; sequential machines; asynchronous machines; machine control; desirable state; static controller; resource usage; controller synthesis; payload data manager; model matching indicator; data managers; internal states; static corrective controllers; dynamic ones; stricter existence conditions; novel static corrective control strategy; model matching problem; relaxed existence condition | ASYNCHRONOUS SEQUENTIAL-MACHINES; FEEDBACK-CONTROL; FAULT-TOLERANT | Managers; Memory management units; Sequential machines; Asynchronous sequential machines; Controller synthesis; Corrective control; Corrective control strategies; Existence conditions; Mass memory units; Model matching problems; Static controllers; Controllers | English | 2020 | 2020-07-23 | 10.1049/iet-cta.2019.1248 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | CFHT MegaPrime/MegaCam u-band source catalogue of the AKARI North Ecliptic PoleWide field | The AKARI infrared (IR) space telescope conducted two surveys (Deep and Wide) in the North Ecliptic Pole (NEP) field to find more than 100 000 IR sources using its infrared camera (IRC). IRC's nine filters, which cover wavebands from 2 to 24 mu m continuously, make AKARI unique in comparison with other IR observatories such as Spitzer or WISE. However, studies of the AKARI NEP-Wide field sources had been limited due to the lack of follow-up observations in the ultraviolet (UV) and optical. In this work, we present the Canada-France-Hawaii Telescope MegaPrime/MegaCam u-band source catalogue of the AKARI NEP-Wide field. The observations were taken in seven nights in 2015 and 2016, resulting in 82 observed frames covering 3.6 deg(2). The data reduction, image processing, and source extraction were performed in a standard procedure using the ELIXIR pipeline and the ASTROMATIC software, and eventually 351 635 sources have been extracted. The data quality is discussed in two regions (shallow and deep) separately, due to the difference in the total integration time (4520 and 13 910 s). The 5 sigma limiting magnitude, seeing full width at half-maximum, and the magnitude at 50 per cent completeness are 25.38 mag (25.79 mag in the deep region), 0.82 arcsec (0.94 arcsec), and 25.06 mag (25.45 mag), respectively. The u-band data provide us with critical improvements to photometric redshifts and UV estimates of the precious infrared sources from the AKARI space telescope. | Huang, Ting-Chi; Matsuhara, Hideo; Goto, Tomotsugu; Shim, Hyunjin; Kim, Seong Jin; Malkan, Matthew A.; Hashimoto, Tetsuya; Hwang, Ho Seong; Oi, Nagisa; Toba, Yoshiki; Lee, Dongseob; Santos, Daryl Joe D.; Takagi, Toshinobu | Grad Univ Adv Studies, Dept Space & Astronaut Sci, SOKENDAI, Hayama, Kanagawa 2400193, Japan; Japan Aerosp Explorat Agcy, Inst Space & Astronaut Sci, Chuo Ku, 3-1-1 Yoshinodai, Sagamihara, Kanagawa 2525210, Japan; Natl Tsing Hua Univ, Inst Astron, 101,Sect 2,Kuang Fu Rd, Hsinchu 30013, Taiwan; Kyungpook Natl Univ, Dept Earth Sci Educ, 80 Daehak Ro, Daegu 41566, South Korea; Univ Calif Los Angeles, Dept Phys & Astron, 475 Portola Plaza, Los Angeles, CA 90095 USA; Natl Tsing Hua Univ, Ctr Informat & Computat Astron CICA, 101,Sect 2,Kuang Fu Rd, Hsinchu 30013, Taiwan; Korea Astron & Space Inst, 776 Daedeok Daero, Daejeon 34055, South Korea; Tokyo Univ Sci, Shinjuku Ku, 1-3 Kagurazaka, Tokyo 1628601, Japan; Kyoto Univ, Dept Astron, Sakyo Ku, Kitashirakawa Oiwake Cho, Kyoto 6068502, Japan; Acad Sinica, Inst Astron & Astrophys, 11F Astron Math Bldg,AS NTU 1,Sect 4,Roosevelt Rd, Taipei 10617, Taiwan; Ehime Univ, Res Ctr Space & Cosm Evolut, 2-5 Bunkyo Cho, Matsuyama, Ehime 7908577, Japan; Japan Space Forum, Chiyoda Ku, 3-2-1 Kandasurugadai, Tokyo 1010062, Japan | Shim, Hyunjin/LZI-7486-2025; HWANG, Ho/AAS-6010-2020; Huang, Teddy/ABB-7532-2020; Malkan, Matthew/IWM-5356-2023; Hashimoto, Tetsuya/ABG-3643-2021 | 57203623570; 7003505733; 57151800100; 14061137700; 57070819300; 7006872661; 24518043000; 15131707100; 23968436800; 37068332400; 57218674853; 57218278835; 35405904800 | s104022505@m104.nthu.edu.tw; | MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY | MON NOT R ASTRON SOC | 0035-8711 | 1365-2966 | 498 | 1 | SCIE | ASTRONOMY & ASTROPHYSICS | 2020 | 5.287 | 22.8 | 0.88 | 2025-06-25 | 15 | 15 | methods: data analysis; catalogues; surveys; galaxies: evolution; galaxies: photometry; ultraviolet: galaxies | catalogues; galaxies: evolution; galaxies: photometry; methods: data analysis; surveys; ultraviolet: galaxies | English | 2020 | 2020-10 | 10.1093/mnras/staa2459 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Cold molecular gas and free-free emission from hot, dust-obscured galaxies at z ∼ 3 | We report on observations of redshifted CO(1-0) line emission and observed-frame similar to 30 GHz radio continuum emission from five ultra-luminous, mid-IR selected hot, Dust-Obscured Galaxies (Hot DOGs) at z greater than or similar to 3 using the Karl G. Jansky Very Large Array. We detect CO(1-0) line emission in all five Hot DOGs, with one of them at high signal-to-noise ratio. We analyse FIR-radio spectral energy distributions, including dust, free-free, and synchrotron emission for the galaxies. We find that most of the 115 GHz rest-frame continuum is mostly due to synchrotron or free-free emission, with only a potentially small contribution from thermal emission. We see a deficit in the rest-frame 115 GHz continuum emission compared to dusty star-forming galaxies and sub-millimetre galaxies (SMGs) at high redshift, suggesting that Hot DOGs do not have similar cold gas reserves compared with star-forming galaxies. One target, W2305-0039, is detected in the FIRST 1.4 GHz survey, and is likely to possess compact radio jets. We compare to the FIR-radio correlation, and find that at least half of the Hot DOGs in our sample are radio-quiet with respect to normal galaxies. These findings suggest that Hot DOGs have comparably less cold molecular gas than star-forming galaxies at lower, z similar to 2 redshifts, and are dominated by powerful, yet radio-quiet AGN. | Penney, J., I; Blain, A. W.; Assef, R. J.; Diaz-Santos, T.; Gonzalez-Lopez, J.; Tsai, C-W; Aravena, M.; Eisenhardt, P. R. M.; Jones, S. F.; Jun, H. D.; Kim, M.; Stern, D.; Wu, J. | Univ Leicester, Dept Phys & Astron, Univ Rd, Leicester LE1 7RH, Leics, England; Univ Diego Portales, Nucleo Astron, Fac Ingn & Ciencias, Av Ejercito Libertador 441, Santiago, Chile; Chinese Acad Sci, Chinese Acad Sci South Amer Ctr Astron CASSACA, Natl Astron Observ, Beijing 100101, Peoples R China; Fdn Res & Technol Hellas, Inst Astrophys, GR-70013 Iraklion, Greece; Carnegie Inst Sci, Las Campanas Observ, Casilla 601, La Serena, Chile; Chinese Acad Sci, Natl Astron Observ, 20A Datun Rd, Beijing 100012, Peoples R China; CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA; Chalmers Univ Technol, Dept Space Earth & Environm, Onsala Space Observ, SE-43992 Onsala, Sweden; Korea Inst Adv Study, Sch Phys, 85 Hoegiro, Seoul 02455, South Korea; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 702701, South Korea | ; Jun, Hyunsung/AAH-3501-2019; Blain, Andrew/HTN-5718-2023; Kim, Minjin/AAU-9910-2020; Diaz-Santos, Tanio/V-1969-2018; Aravena, Manuel/O-2361-2014; Assef, Roberto/S-7842-2019 | 57203609239; 7006989462; 15078033000; 55910071800; 56074405200; 36663120700; 23468406500; 7006733209; 55474003600; 27067602700; 56898213300; 7202386545; 7409260861 | jip3@le.ac.uk;ab520@leicester.ac.uk; | MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY | MON NOT R ASTRON SOC | 0035-8711 | 1365-2966 | 496 | 2 | SCIE | ASTRONOMY & ASTROPHYSICS | 2020 | 5.287 | 22.8 | 0.61 | 2025-06-25 | 16 | 16 | galaxies: active; galaxies: evolution; radio lines: galaxies | SUBMILLIMETER GALAXIES; RADIO PROPERTIES; HIGH-REDSHIFT; PHYSICS; QUASARS; MERGERS | Galaxies: active; Galaxies: evolution; Radio lines: galaxies | Dust; FIR filters; Gases; Molecules; Red Shift; Signal to noise ratio; Stars; Continuum emission; Galaxies active; Galaxy evolution; Hot dust; Line emissions; Molecular gas; Radio continuum; Radio lines:galaxies; Red-shifted; Star forming galaxy; Galaxies | English | 2020 | 2020-08 | 10.1093/mnras/staa1582 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Exploring the Operation Factors that Influence Performance of a Spiral-Wound Forward Osmosis Membrane Process for Scale-up Design | Forward osmosis (FO) technology has increasingly attracted attention owing to its low operational energy and low fouling propensity. Despite extensive investigations on FO, very few module-scale FO studies on the operation and design of the FO process have been conducted. In this paper, a simple and practical FO process design parameter called normalized membrane area is suggested based on a performance analysis of spiral-wound FO elements. The influence of operation factors on operating pressures and water recovery was investigated using 8-inch spiral wound elements in the continuous operation mode. The membrane area was adjusted by series connection of FO elements to a maximum value of 46 m(2) (three elements). The feed and draw flow rates were varied between 5 and 15 LPM under various feed (10, 20, and 30 g/L) and draw (58.4 and 233.8 g/L) concentration combinations. The analysis of flow rates (feed, draw, and permeate flow rates) indicated not only high flow channel resistance on the draw side but also high permeate flow rates can induce higher operating pressures owing to strong mutual interaction of the feed and the draw streams. Feed water recovery was focused on as a key performance index, and the experimental recovery (R-Exp) and theoretical maximum recovery (R-Th) values were compared. The results revealed the significance of the feed flow rate and the membrane area in terms of enhancing the water recovery performance. In addition, a clear relationship was observed between the membrane area normalized by the initial feed flow rates and the water recovery ratio (R-Exp/R-Th), even though the applied operation conditions were different. Finally, an empirical equation to estimate the required membrane area of spiral-wound FO was proposed for the FO process design. The equation can be used to predict water recovery of FO systems as well, for example, if an FO system is operated at 0.08 m(2)L(-1)h of the normalized membrane area, the system is expected to offer 78% of the R-Th value. | Lee, Sungyun | Kyungpook Natl Univ, Sch Disaster Prevent & Environm Engn, Dept Civil Environm Engn, 2559 Gyeongsang Daero, Sangju Si 37224, Gyeongsangbuk D, South Korea; Korea Inst Machinery & Mat, Dept Environm Machinery, Daejeon 34103, South Korea | Lee, Sang-Eun/HJH-1132-2023 | 36438267000 | sungyunlee@knu.ac.kr; | MEMBRANES | MEMBRANES-BASEL | 2077-0375 | 10 | 3 | SCIE | CHEMISTRY, PHYSICAL;ENGINEERING, CHEMICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;POLYMER SCIENCE | 2020 | 4.106 | 22.8 | 0.18 | 2025-06-25 | 7 | 8 | forward osmosis; spiral-wound; water recovery; normalized membrane area; FO process design | PLATE-AND-FRAME; SEAWATER DESALINATION; FERTILIZER DRAWN; FOULING BEHAVIOR; WATER-TREATMENT; REVERSE; MODULE; ENERGY; SYSTEM; TECHNOLOGY | FO process design; Forward osmosis; Normalized membrane area; Spiral-wound; Water recovery | Channel flow; Design; Flow rate; Process design; Recovery; Forward osmosis; Forward osmosis membranes; Key performance index; Membrane area; Operation conditions; Process design parameters; Spiral wound; Water recovery; Membranes | English | 2020 | 2020-03 | 10.3390/membranes10030053 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Extinction-free Census of AGNs in the AKARI/IRC North Ecliptic Pole Field from 23-band infrared photometry from Space Telescopes | In order to understand the interaction between the central black hole and the whole galaxy or their co-evolution history along with cosmic time, a complete census of active galactic nucleus (AGN) is crucial. However, AGNs are often missed in optical, UV, and soft X-ray observations since they could be obscured by gas and dust. A mid-infrared (MIR) survey supported by multiwavelength data is one of the best ways to find obscured AGN activities because it suffers less from extinction. Previous large IR photometric surveys, e.g. Wide field Infrared Survey Explorer and Spitzer, have gaps between the MIR filters. Therefore, star-forming galaxy-AGN diagnostics in the MIR were limited. The AKARI satellite has a unique continuous nine-band filter coverage in the near to MIR wavelengths. In this work, we take advantage of the state-of-the-art spectral energy distribution modelling software, CIGALE, to find AGNs in MIR. We found 126 AGNs in the North Ecliptic Pole-Wide field with this method. We also investigate the energy released from the AGN as a fraction of the total IR luminosity of a galaxy. We found that the AGN contribution is larger at higher redshifts for a given IR luminosity. With the upcoming deep IR surveys, e.g. JWST, we expect to find more AGNs with our method. | Wang, Ting-Wen; Goto, Tomotsugu; Kim, Seong Jin; Hashimoto, Tetsuya; Burgarella, Denis; Toba, Yoshiki; Shim, Hyunjin; Miyaji, Takamitsu; Hwang, Ho Seong; Jeong, Woong-Seob; Kim, Eunbin; Ikeda, Hiroyuki; Pearson, Chris; Malkan, Matthew; Oi, Nagisa; Santos, Daryl Joe D.; Pollo, Agnieszka; Ho, Simon C-C; Matsuhara, Hideo; On, Alvina Y. L.; Kim, Helen K.; Hsiao, Tiger Yu-Yang; Huang, Ting-Chi | Natl Tsing Hua Univ, Inst Astron, 101,Sect 2,Kuang Fu Rd, Hsinchu 30013, Taiwan; Natl Tsing Hua Univ, Ctr Informat & Computat Astron CICA, 101,Sect 2,Kuang Fu Rd, Hsinchu 30013, Taiwan; Aix Marseille Univ, CNES, CNRS, F-13388 Lam Marseille, France; Kyoto Univ, Dept Astron, Sakyo Ku, Kitashirakawa Oiwake Cho, Kyoto 6068502, Japan; Acad Sinica, Inst Astron & Astrophys, 11F Astron Math Bldg,AS NTU 1,Sect 4,Roosevelt Rd, Taipei 10617, Taiwan; Ehime Univ, Res Ctr Space & Cosm Evolut, 2-5 Bunkyo Cho, Matsuyama, Ehime 7908577, Japan; Kyungpook Natl Univ, Dept Earth Sci Educ, Daehak Ro 80, Daegu 41566, South Korea; Univ Nacinal Autonoma Mexico IA UNAM E, Inst Astrn Sede Ensenada, Km 107,Carret Tij Ens, Ensenada 22860, Baja California, Mexico; Leibnitz Inst Astrophys AIP, Sternwarte 16, D-14482 Potsdam, Germany; Korea Astron & Space Sci Inst, Daedeokdae Ro 776, Daejeon 34055, South Korea; Korea Univ Sci & Technol, 217 Gajeong Ro, Daejeon 34113, South Korea; Wakayama Coll, Natl Inst Technol, Wakayama 6440023, Japan; STFC Rutherford Appleton Lab, RAL Space, Didcot OX11 0QX, Oxon, England; Open Univ, Milton Keynes MK7 6AA, Bucks, England; Univ Oxford, Keble Rd, Oxford OX1 3RH, England; Univ Calif Los Angeles, Dept Phys & Astron, 475 Portola Plaza, Los Angeles, CA 90095 USA; Tokyo Univ Sci, Shinjuku Ku, 1-3 Kagurazaka, Tokyo 1628601, Japan; Natl Ctr Nucl Res, Ul Pasteura 7, PL-02931 Warsaw, Poland; Jagiellonian Univ, Astron Observ, Ul Orla 171, PL-30244 Krakow, Poland; Grad Univ Adv Studies, Dept Space & Astronaut Sci, SOKENDAI, Hayama, Kanagawa 2400193, Japan; Japan Aerosp Explorat Agcy, Inst Space & Astronaut Sci, Chuo Ku, 3-1-1 Yoshinodai, Sagamihara, Kanagawa 2525210, Japan; Univ Coll London, Mullard Space Sci Lab, Dorking RH5 6NT, Surrey, England | ; HWANG, Ho/AAS-6010-2020; Shim, Hyunjin/LZI-7486-2025; Hashimoto, Tetsuya/ABG-3643-2021; Malkan, Matthew/IWM-5356-2023 | 57211574957; 57151800100; 57070819300; 24518043000; 8852232400; 37068332400; 14061137700; 57203194972; 15131707100; 7102145940; 55202031200; 44561165200; 55531949600; 7006872661; 23968436800; 57218278835; 56210521800; 56234075800; 57216812477; 7003505733; 57214263438; 57203269860; 57218282309; 57203623570 | tinattw0127@gapp.nthu.edu.tw; | MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY | MON NOT R ASTRON SOC | 0035-8711 | 1365-2966 | 499 | 3 | SCIE | ASTRONOMY & ASTROPHYSICS | 2020 | 5.287 | 22.8 | 0.75 | 2025-06-25 | 15 | 19 | galaxies: active; galaxies: high-redshift | ACTIVE GALACTIC NUCLEI; STAR-FORMATION; SOURCE CATALOG; XMM-NEWTON; GALAXIES; COEVOLUTION; SELECTION; SAMPLE; DUST | Galaxies: active; Galaxies: high-redshift | English | 2020 | 2020-12 | 10.1093/mnras/staa2988 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Measurement and verification analysis on the energy performance of a retrofit residential building after energy efficiency measures using RETScreen Expert | Korean old residential apartments built over many decades were constructed without proper energy efficiency measures. This makes the energy performance of existing buildings to be very poor when compared with the energy performance of new buildings. This study presents the use of a 12 years gas consumption data to evaluate the energy performance of an existing residential building in Korea by carrying out Measurement and Verification (M&V) analysis using RETScreen Expert software after building retrofit. From the analysis, a total of 249 Giga Joules (GJ) of Liquefied Natural Gas (LNG) was consumed at the rate of 0.17 GJ/day on an average from the year 2011 to 2014 with the peak consumption in the year 2013 costing the occupant a sum of $5,401. Also, the net energy savings was 64GJ as of June 2019 after the installation of an Energy Conservation Measures (ECMs) with the highest between the year 2016 and 2018. An energy forecast for the year 2020 indicates that 2.71 (tCO(2)) GHG emissions will be reduced as a result of the energy that will be saved from the 54 Giga Joule (GJ) fuel consumed. Finally, energy efficiency was attained and this reduced the resident doubt on the benefits of energy efficiency measures. (C) 2020 The Authors. Published by Elsevier B.V. | Owolabi, Abdulhameed Babatunde; Nsafon, Benyoh Emmanuel Kigha; Roh, Jong Wook; Suh, Dongjun; Huh, Jeung-Soo | Kyungpook Natl Univ, Dept Climate Change, Inst Global Climate Change & Energy, Grad Sch, Daegu 41566, South Korea | 57192210107; 57218858906; 25638796100; 36613529600; 7102258915 | owolabiabdulhameed@gmail.com;jshuh@knu.ac.kr; | ALEXANDRIA ENGINEERING JOURNAL | ALEX ENG J | 1110-0168 | 2090-2670 | 59 | 6 | SCIE | ENGINEERING, MULTIDISCIPLINARY | 2020 | 3.732 | 22.8 | 1.39 | 2025-06-25 | 18 | 24 | Energy Conservation Measures (ECMs); Energy consumption; Performance analysis; Energy savings; RETScreen Expert software; Residential building | CONSUMPTION; PREDICTION; BENCHMARKING | Energy Conservation Measures (ECMs); Energy consumption; Energy savings; Performance analysis; Residential building; RETScreen Expert software | Greenhouse gases; Housing; Liquefied natural gas; Retrofitting; Verification; Building retrofits; Efficiency measure; Energy conservation measures; Energy performance; Existing residential buildings; Liquefied Natural Gas (LNG); Measurement and verification; Residential building; Energy efficiency | English | 2020 | 2020-12 | 10.1016/j.aej.2020.08.022 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: