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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Characterization and Comparison of Two Complete Plastomes of Rosaceae Species (Potentilla dickinsiivar.glabrataandSpiraeainsularis) Endemic to Ulleung Island, Korea | Potentilla dickinsiivar.glabrataandSpiraea insularisin the family Rosaceae are species endemic to Ulleung Island, Korea, the latter of which is listed as endangered. In this study, we characterized the complete plastomes of these two species and compared these with previously reported plastomes of other Ulleung Island endemic species of Rosaceae (Cotoneaster wilsonii,Prunus takesimensis,Rubus takesimensis, andSorbus ulleungensis). The highly conserved complete plastomes ofP. dickinsiivar.glabrataandS. insularisare 158,637 and 155,524 base pairs with GC contents of 37% and 36.9%, respectively. Comparative phylogenomic analysis identified three highly variable intergenic regions (trnT-UGU/trnL-UAA,rpl32/trnL-UAG, andndhF/rpl32) and one variable genic region (ycf1). Only 6 of the 75 protein-coding genes have been subject to strong positive selection. Phylogenetic analysis of 23 representative plastomes within the Rosaceae supported the monophyly ofPotentillaand the sister relationship betweenPotentillaandFragariaand indicated thatS. insularisis sister to a clade containingCotoneaster,Malus,Pyrus, andSorbus. The plastome resources generated in this study will contribute to elucidating the plastome evolution of insular endemic Rosaceae on Ulleung Island and also in assessing the genetic consequences of anagenetic speciation for various endemic lineages on the island. | Yang, JiYoung; Kang, Gi-Ho; Pak, Jae-Hong; Kim, Seung-Chul | Kyungpook Natl Univ, Sch Life Sci, Res Inst Dok Do & Ulleung Do Isl, Dept Biol, 80 Daehak Ro, Daegu 41566, Gyeongsangbuk D, South Korea; Baekdudaegan Natl Arboretum, 1501 Chunyang Ro, Bonghwa Gun 36209, Gyeongsangbuk D, South Korea; Sungkyunkwan Univ, Dept Biol Sci, 2066 Seobu Ro, Suwon 16419, Gyeonggi Do, South Korea | Kim, Seung-Chul/AAR-6157-2020 | 55193226000; 57218102178; 7102232932; 57214983739 | whity@daum.net;supia@kiam.or.kr;jhpak@knu.ac.kr;sonchus96@skku.edu; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 14 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.72 | 2025-06-25 | 19 | 17 | Potentilla dickinsiivar; glabrata; Spiraea insularis; Rosaceae; Ulleung Island; plastome; anagenetic speciation | COMPLETE CHLOROPLAST GENOME; PHYLOGENETIC ANALYSIS; ULLUNG ISLAND; ANAGENETIC SPECIATION; SEQUENCE; GENES; DIVERSIFICATION; SAPINDACEAE; EVOLUTION; SELECTION | Anagenetic speciation; Plastome; Potentilla dickinsii var. glabrata; Rosaceae; Spiraea insularis; Ulleung Island | Chloroplasts; Codon Usage; Conserved Sequence; Genetic Speciation; Genome, Plastid; Islands; Korea; Likelihood Functions; Phylogeny; Potentilla; Rosaceae; Selection, Genetic; Species Specificity; Spiraea; article; cladistics; controlled study; DNA base composition; endemic species; female; Fragaria; Korea; monophyly; nonhuman; Potentilla; Prunus; purifying selection; Pyrus; Rubus; Sorbus; species differentiation; Spiraea; chloroplast; codon usage; comparative study; conserved sequence; genetic selection; genetics; island (geological); Korea; phylogeny; plastid genome; Potentilla; Rosaceae; species difference; species differentiation; Spiraea; statistical model | English | 2020 | 2020-07 | 10.3390/ijms21144933 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Chemerin Treatment Inhibits the Growth and Bone Invasion of Breast Cancer Cells | Chemerin is secreted as prochemerin from various cell types and then cleaved into the bioactive isoform by specific proteases. In various cancer types, chemerin exhibits pro- or antitumor effects. In the present study, chemerin treatment significantly inhibited the viability and invasion of breast cancer cells in the absence or presence of transforming growth factor (TGF)-beta and insulin-like growth factor (IGF)-1. The expression levels of E-cadherin and vimentin were reduced in chemerin-treated breast cancer cells. However, chemerin treatment recovered the reduced E-cadherin expression level in breast cancer cells treated with TGF-beta or IGF-1. Chemerin treatment inhibited nuclear beta-catenin levels in breast cancer cells stimulated with or without TGF-beta or IGF-1. In addition, chemerin treatment blocked the increase in the receptor activator of nuclear factor kappa-Beta ligand (RANKL)/osteoprotegerin (OPG) ratio in osteoblastic cells exposed to metastatic breast cancer cell-derived conditioned medium. Chemerin treatment inhibited RANKL-induced osteoclast formation and bone resorption by reducing the secretion of matrix metalloproteinase (MMP)-2, MMP-9, and cathepsin K. Intraperitoneal administration of chemerin inhibited tumor growth in MCF-7 breast cancer cell-injected mice and reduced the development of osteolytic lesions resulting from intratibial inoculation of MDA-MB-231 cells. Taken together, chemerin inhibits the growth and invasion of breast cancer cells and prevents bone loss resulting from breast cancer cells by inhibiting finally osteoclast formation and activity. | Kim, Hyungkeun; Lee, Joo-Hee; Lee, Sun Kyoung; Song, Na-Young; Son, Seung Hwa; Kim, Ki Rim; Chung, Won-Yoon | Yonsei Univ, Grad Sch, Dept Appl Life Sci, Seoul 03722, South Korea; Yonsei Univ, Dept Oral Biol, Coll Dent, Seoul 03722, South Korea; Yonsei Univ, BK21 PLUS Project, Coll Dent, Seoul 03722, South Korea; Yonsei Univ, Oral Canc Res Inst, Coll Dent, Seoul 03722, South Korea; Kyungpook Natl Univ, Dept Dent Hyg, Coll Sci & Engn, Sangju 37224, South Korea | 57196215643; 57203640219; 37056867800; 55387067100; 24400193300; 35793746200; 7401983103 | khg165@gmail.com;jhlee1201@yuhs.ac;lpluto@yuhs.ac;nysong608@yuhs.ac;shson0729@yuhs.ac;rim0804@knu.ac.kr;wychung@yuhs.ac; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 1.52 | 2025-06-25 | 29 | 27 | chemerin; breast cancer cell invasion; EMT; RANKL; OPG; bone resorption | BODY-MASS INDEX; EPITHELIAL-MESENCHYMAL TRANSITION; POOR-PROGNOSIS; EXPRESSION; SERUM; COAGULATION; PREVENTION; MORTALITY; CARCINOMA; RARRES2 | Bone resorption; Breast cancer cell invasion; Chemerin; EMT; RANKL/OPG | Animals; Antineoplastic Agents; Biomarkers; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokines; Disease Models, Animal; Female; Gene Expression; Humans; Immunophenotyping; Mice; Osteoprotegerin; RANK Ligand; Xenograft Model Antitumor Assays; 2 (2 amino 3 methoxyphenyl)chromone; 2 (2 difluoromethylbenzimidazol 1 yl) 4,6 dimorpholino 1,3,5 triazine; acid phosphatase tartrate resistant isoenzyme; beta catenin; c terminal cross linking telopeptide of type I collagen; cadherin; calcium; cathepsin K; chemerin; colony stimulating factor 1; gelatinase A; gelatinase B; mitogen activated protein kinase 1; mitogen activated protein kinase 3; osteoclast differentiation factor; osteoprotegerin; protein inhibitor; SB525334; Smad2 protein; Smad3 protein; somatomedin C; transforming growth factor beta; unclassified drug; vimentin; antineoplastic agent; biological marker; chemokine; osteoclast differentiation factor; osteoprotegerin; RARRES2 protein, human; animal cell; animal experiment; animal model; Article; bone atrophy; bone metastasis; breast cancer; cell growth; cell invasion; cell migration; cell viability; confocal microscopy; controlled study; down regulation; enzyme linked immunosorbent assay; epithelial mesenchymal transition; female; flow cytometry; mouse; MTT assay; nonhuman; osteoclastogenesis; osteolysis; protein expression; tumor growth; upregulation; Western blotting; zymography; animal; bone tumor; breast tumor; cell motion; cell proliferation; disease model; drug effect; drug screening; gene expression; human; immunophenotyping; metabolism; pathology; tumor cell line | English | 2020 | 2020-04 | 10.3390/ijms21082871 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Cloning and Functional Characterization of Dihydroflavonol 4-Reductase Gene Involved in Anthocyanin Biosynthesis of Chrysanthemum | Dihydroflavonol 4-reductase (DFR) catalyzes a committed step in anthocyanin and proanthocyanidin biosynthesis by reducing dihydroflavonols to leucoanthocyanidins. However, the role of this enzyme in determining flower color in the economically important crop chrysanthemum (Chrysanthemum morifolium Ramat.) is unknown. Here, we isolated cDNAs encoding DFR from two chrysanthemum cultivars, the white-flowered chrysanthemum "OhBlang" (CmDFR-OB) and the red-flowered chrysanthemum "RedMarble" (CmDFR-RM) and identified variations in the C-terminus between the two sequences. An enzyme assay using recombinant proteins revealed that both enzymes catalyzed the reduction of dihydroflavonol substrates, but CmDFR-OB showed significantly reduced DFR activity for dihydrokaempferol (DHK) substrate as compared with CmDFR-RM. Transcript levels of anthocyanin biosynthetic genes were consistent with the anthocyanin contents at different flower developmental stages of both cultivars. The in planta complementation assay, using Arabidopsis thaliana dfr mutant (tt3-1), revealed that CmDFR-RM, but not CmDFR-OB, transgenes restored defective anthocyanin biosynthesis of this mutant at the seedling stage, as well as proanthocyanidin biosynthesis in the seed. The difference in the flower color of two chrysanthemums can be explained by the C-terminal variation of CmDFR combined with the loss of CmF3H expression during flower development. | Lim, Sun-Hyung; Park, Bora; Kim, Da-Hye; Park, Sangkyu; Yang, Ju-Hee; Jung, Jae-A; Lee, JeMin; Lee, Jong-Yeol | Hankyong Natl Univ, Sch Biotechnol, Div Hort Biotechnol, Anseong 17579, South Korea; Rural Dev Adm, Natl Inst Agr Sci, Jeonju 54874, South Korea; Kyungpook Natl Univ, Dept Hort Sci, Daegu 41566, South Korea; Rural Dev Adm, Floriculture Res Div, Natl Inst Hort & Herbal Sci, Wonju 55365, South Korea | Lee, Jungmin/KHT-2438-2024; Lee, Je/AAE-7496-2020; Lee, Je Min/F-9797-2014 | 7404081419; 57209529309; 59109633500; 57205609786; 57214775581; 57711123400; 8885729900; 38861955900 | limsh2@hknu.ac.kr;pbr0915@naver.com;kimdh143@korea.kr;psk2779@korea.kr;juheeppuing@korea.kr;jabisung@korea.kr;jemin@knu.ac.kr;jy0820@korea.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 21 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 1.38 | 2025-06-25 | 26 | 26 | anthocyanin; chrysanthemum; dihydroflavonol 4-reductase; flavonoid; flower color | IDENTIFICATION; FLAVONOIDS; EXPRESSION | Anthocyanin; Chrysanthemum; Dihydroflavonol 4-reductase; Flavonoid; Flower color | Alcohol Oxidoreductases; Anthocyanins; Base Sequence; Chrysanthemum; Cloning, Molecular; Flavonoids; Flowers; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Genetic Variation; Phylogeny; Plant Proteins; anthocyanidin reductase; anthocyanidin synthase; anthocyanin; chalcone isomerase; chalcone synthase; complementary DNA; dihydroflavonol 4 reductase; dihydrokaempferol; flavanone 3 hydroxylase; flavonoid 3 o glucosyltransferase; flavonoid 3' hydroxylase; flavonoid 3',5' hydroxylase; flavonol synthase; glucosyltransferase; glutathione transferase; kaempferol; leucoanthocyanidin reductase; oxidoreductase; oxygenase; plant DNA; plant protein; proanthocyanidin; recombinant protein; synthetase; unclassified drug; alcohol dehydrogenase; anthocyanin; aromadedrin; dihydroflavanol 4-reductase; flavonoid; plant protein; Actinidia chinensis; Agapanthus praecox; amino acid sequence; amino acid substitution; Antirrhinum; Antirrhinum majus; Arabidopsis thaliana; Article; biosynthesis; Callistephus chinensis; Camellia sinensis; Capsicum annuum; carboxy terminal sequence; carrot; Chrysanthemum; Chrysanthemum morifolium; cloning; comparative study; controlled study; cultivar; developmental stage; enzyme activity; enzyme assay; enzyme mechanism; enzyme substrate; flower color; flower development; gene expression; gene expression level; Gentiana triflora; Gerbera hybrida; grape; Gynura bicolor; Helianthus annuus; indel mutation; Ipomoea purpurea; Iris hollandica; Lilium hybrida; Lonicera caerulea; maize; Muscari armeniacum; nonhuman; Perilla frutescens; Petunia; Petunia hybrida; phylogeny; plant gene; potato; rice; seedling; sequence alignment; sweet potato; transgene; Chrysanthemum; classification; flower; gene expression regulation; genetic variation; genetics; growth, development and aging; metabolism; molecular cloning; nucleotide sequence | English | 2020 | 2020-11 | 10.3390/ijms21217960 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Combined Poziotinib with Manidipine Treatment Suppresses Ovarian Cancer Stem-Cell Proliferation and Stemness | Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy in women worldwide, with an overall 5 year survival rate below 30%. The low survival rate is associated with the persistence of cancer stem cells (CSCs) after chemotherapy. Therefore, CSC-targeting strategies are required for successful EOC treatment. Pan-human epidermal growth factor receptor 4 (HER4) and L-type calcium channels are highly expressed in ovarian CSCs, and treatment with the pan-HER inhibitor poziotinib or calcium channel blockers (CCBs) selectively inhibits the growth of ovarian CSCs via distinct molecular mechanisms. In this study, we tested the hypothesis that combination treatment with poziotinib and CCBs can synergistically inhibit the growth of ovarian CSCs. Combined treatment with poziotinib and manidipine (an L-type CCB) synergistically suppressed ovarian CSC sphere formation and viability compared with either drug alone. Moreover, combination treatment synergistically reduced the expression of stemness markers, including CD133, KLF4, and NANOG, and stemness-related signaling molecules, such as phospho-STAT5, phospho-AKT, phospho-ERK, and Wnt/beta-catenin. Moreover, poziotinib with manidipine dramatically induced apoptosis in ovarian CSCs. Our results suggest that the combinatorial use of poziotinib with a CCB can effectively inhibit ovarian CSC survival and function. | Lee, Heejin; Kim, Jun Woo; Lee, Dong-Seok; Min, Sang-Hyun | Daegu Gyeongbuk Med Innovat Fdn DGMIF, New Drug Dev Ctr, 80 Chumbok Ro, Daegu 41061, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Creat BioRes Grp, Sch Life Sci & Biotechnol, Daegu 41566, South Korea | 57202875112; 57215818625; 57210068061; 7202852238 | free7e77@knu.ac.kr;jwkim@dgmif.re.kr;lee1@knu.ac.kr;shmin03@dgmif.re.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 19 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.43 | 2025-06-25 | 15 | 13 | drug synergism; poziotinib; manidipine; cancer stem cells; stemness; Wnt/beta-catenin; STAT5; calcium channel blocker | CHEMOTHERAPY; EPIDEMIOLOGY; COMBINATION | Calcium channel blocker; Cancer stem cells; Drug synergism; Manidipine; Poziotinib; STAT5; Stemness; Wnt/β-catenin | AC133 Antigen; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Dihydropyridines; Female; Humans; Kruppel-Like Transcription Factors; Nanog Homeobox Protein; Neoplastic Stem Cells; Nitrobenzenes; Ovarian Neoplasms; Piperazines; Quinazolines; STAT5 Transcription Factor; Treatment Outcome; Tumor Suppressor Proteins; Wnt Signaling Pathway; beta catenin; calcium channel blocking agent; CD133 antigen; epidermal growth factor receptor 4; kruppel like factor 4; manidipine; mitogen activated protein kinase; poziotinib; protein kinase B; STAT5 protein; transcription factor NANOG; Wnt protein; antineoplastic agent; dihydropyridine derivative; kruppel like factor; manidipine; NANOG protein, human; nitrobenzene derivative; piperazine derivative; poziotinib; PROM1 protein, human; quinazoline derivative; STAT5A protein, human; tumor suppressor protein; A2780 cell line; Article; cancer inhibition; cancer stem cell; cell proliferation; controlled study; drug potentiation; ovary carcinoma; protein expression; SK-OV-3 cell line; apoptosis; cancer stem cell; cell proliferation; drug effect; female; genetics; human; metabolism; ovary tumor; pathophysiology; physiology; treatment outcome; tumor cell line; Wnt signaling | English | 2020 | 2020-10 | 10.3390/ijms21197379 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Developmental Roles of FUSE Binding Protein 1 (Fubp1) in Tooth Morphogenesis | FUSE binding protein 1 (Fubp1), a regulator of the c-Myc transcription factor and a DNA/RNA-binding protein, plays important roles in the regulation of gene transcription and cellular physiology. In this study, to reveal the precise developmental function of Fubp1, we examined the detailed expression pattern and developmental function of Fubp1 during tooth morphogenesis by RT-qPCR, in situ hybridization, and knock-down study using in vitro organ cultivation methods. In embryogenesis, Fubp1 is obviously expressed in the enamel organ and condensed mesenchyme, known to be important for proper tooth formation. Knocking down Fubp1 at E14 for two days, showed the altered expression patterns of tooth development related signalling molecules, including Bmps and Fgf4. In addition, transient knock-down of Fubp1 at E14 revealed changes in the localization patterns of c-Myc and cell proliferation in epithelium and mesenchyme, related with altered tooth morphogenesis. These results also showed the decreased amelogenin and dentin sialophosphoprotein expressions and disrupted enamel rod and interrod formation in one- and three-week renal transplanted teeth respectively. Thus, our results suggested that Fubp1 plays a modulating role during dentinogenesis and amelogenesis by regulating the expression pattern of signalling molecules to achieve the proper structural formation of hard tissue matrices and crown morphogenesis in mice molar development. | Aryal, Yam Prasad; Neupane, Sanjiv; Kim, Tae-Young; Lee, Eui-Seon; Pokhrel, Nitin Kumar; Yeon, Chang-Yeol; Kim, Ji-Youn; An, Chang-Hyeon; An, Seo-Young; Park, Eui-Kyun; Ha, Jung-Hong; Jung, Jae-Kwang; Yamamoto, Hitoshi; Cho, Sung-Won; Lee, Sanggyu; Kim, Do-Yeon; Kwon, Tae-Yub; Lee, Youngkyun; Sohn, Wern-Joo; Kim, Jae-Young | Kyungpook Natl Univ, Sch Dent, Dept Biochem, IHBR, 2177 Dalgubeol Daero, Daegu 41940, South Korea; SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11784 USA; Gachon Univ, Dept Dent Hyg, Incheon 21936, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Radiol, IHBR, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Pathol & Regenerat Med, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Conservat Dent, IHBR, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Med, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Tokyo Dent Coll, Dept Histol & Dev Biol, Tokyo 1010061, Japan; Yonsei Univ, Dept Oral Biol, Div Anat & Dev Biol, Coll Dent, Seoul 26493, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Dent Biomat, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Daegu Haany Univ, Cosmet & Pharmaceut, Gyongsan 38610, South Korea | ; Kim, Do-Yeon/AET-3021-2022; CHO, Sung-Won/HDO-3680-2022; Kim, Ji-Youn/A-5779-2017 | 57202611163; 56183800400; 57208461628; 57202610354; 57193827745; 57211854259; 57157491000; 17134437600; 55258203200; 37071072400; 55549831900; 55970994400; 55725330600; 56456948900; 7601418915; 57203012542; 7202206084; 36062942200; 44161404800; 56812734700 | yparyal86@gmail.com;sanjiv.knu@gmail.com;tae09290@daum.net;euiseon3488@gmail.com;nitinpokhrel.np@gmail.com;yhs2669@naver.com;hoho6434@gachon.ac.kr;chan@knu.ac.kr;syan@knu.ac.kr;epark@knu.ac.kr;endoking@knu.ac.kr;widenmy@knu.ac.kr;hyamamoto@tdc.ac.jp;chosome1@yuhs.ac;slee@knu.ac.kr;dykim82@knu.ac.kr;tykwon@knu.ac.kr;ylee@knu.ac.kr;wjsohn@dhu.ac.kr;jykim91@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 21 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.29 | 2025-06-25 | 6 | 7 | Fubp1; dentinogenesis; amelogenesis; transcriptional regulator; tooth development | C-MYC EXPRESSION; CELL-PROLIFERATION; MOLAR TOOTH; E-CADHERIN; GENES; CUSP | Amelogenesis; Dentinogenesis; Fubp1; Tooth development; Transcriptional regulator | Animals; Cell Proliferation; DNA-Binding Proteins; Embryo, Mammalian; Gene Expression Regulation, Developmental; Mice; Mice, Inbred ICR; Morphogenesis; Odontogenesis; RNA-Binding Proteins; Signal Transduction; Tooth; alpha tubulin; ameloblastin; amelogenin; beta catenin; bone morphogenetic protein 2; bone morphogenetic protein 4; dentin matrix protein 1; DNA binding protein; fibroblast growth factor 4; fuse binding protein 1; hypoxanthine phosphoribosyltransferase; Ki 67 antigen; lymphoid enhancer factor 1; Myc protein; nestin; phalloidin; regulator protein; Rho kinase; RNA binding protein; small interfering RNA; sonic hedgehog protein; unclassified drug; uvomorulin; DNA binding protein; FUBP1 protein, human; RNA binding protein; ameloblast; Amelx gene; animal experiment; animal tissue; Article; cell proliferation; controlled study; dentin; dentinogenesis; down regulation; Dspp gene; embryo; embryo development; enamel; enamel organ; epithelium; gene; immunohistochemistry; in situ hybridization; in vitro study; kidney capsule; male; mesenchyme; morphogenesis; mouse; nonhuman; odontoblast; oncogene c myc; protein expression; protein function; protein localization; real time polymerase chain reaction; scanning electron microscopy; tooth development; tooth papilla; transcription regulation; Western blotting; animal; cytology; embryology; gene expression regulation; genetics; Institute for Cancer Research mouse; mammalian embryo; metabolism; signal transduction; tooth; tooth development | English | 2020 | 2020-11 | 10.3390/ijms21218079 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release | Developmentally regulated GTP-binding protein 2 (DRG2) was first identified in the central nervous system of mice. However, the physiological function of DRG2 in the brain remains largely unknown. Here, we demonstrated that knocking out DRG2 impairs the function of dopamine neurons in mice. DRG2 was strongly expressed in the neurons of the dopaminergic system such as those in the striatum (Str), ventral tegmental area (VTA), and substantia nigra (SN), and on neuronal cell bodies in high-density regions such as the hippocampus (HIP), cerebellum, and cerebral cortex in the mouse brain. DRG2 knockout (KO) mice displayed defects in motor function in motor coordination and rotarod tests and increased anxiety. However, unexpectedly, DRG2 depletion did not affect the dopamine (DA) neuron population in the SN, Str, or VTA region or dopamine synthesis in the Str region. We further demonstrated that dopamine release was significantly diminished in the Str region of DRG2 KO mice and that treatment of DRG2 KO mice with l-3,4-dihydroxyphenylalanine (L-DOPA), a dopamine precursor, rescued the behavioral motor deficiency in DRG2 KO mice as observed with the rotarod test. This is the first report to identify DRG2 as a key regulator of dopamine release from dopamine neurons in the mouse brain. | Lim, Hye Ryeong; Vo, Mai-Tram; Kim, Dong Jun; Lee, Unn Hwa; Yoon, Jong Hyuk; Kim, Hyung-Jun; Kim, Jeongah; Kim, Sang Ryong; Lee, Jun Yeon; Yang, Chae Ha; Kim, Hee Young; Choi, June-Seek; Kim, Kijeong; Yang, Esther; Kim, Hyun; Lee, Seongsoo; Lee, Byung Ju; Kim, Kyungjin; Park, Jeong Woo; Ha, Chang Man | Korea Brain Res Inst, Res Div, Daegu 41068, South Korea; Korea Brain Res Inst, Brain Res Core Facil, Korea Brain Res Inst, Daegu 41068, South Korea; Univ Ulsan, Dept Biol Sci, Ulsan 44610, South Korea; Korea Brain Res Inst, Dementia Res Grp, Daegu 41068, South Korea; Korea Brain Res Inst, Neurodegenerat Dis Grp, Daegu 41068, South Korea; DGIST, Dept Brain & Cognit Sci, Daegu 42988, South Korea; Kyungpook Natl Univ, Sch Life Sci, Plus KNU Creat BioRes Grp BK21, Daegu 41566, South Korea; Daegu Haany Univ, Coll Korean Med, Daegu 42158, South Korea; Korea Univ, Dept Psychol, Seoul 02841, South Korea; Univ Ulsan, Sch Exercise & Sport Sci, Ulsan 44610, South Korea; Korea Univ, Dept Anat, Coll Med, Seoul 02841, South Korea; Korea Basic Sci Inst KBSI, Gwangju Ctr, Gwangju 61886, South Korea | Kim, Do Hyun/AAA-2792-2021; Kim, Hee/F-4594-2014 | 57212505315; 6602138195; 57208598276; 7102225110; 57212513350; 57191717907; 57193904062; 56486163800; 57190220624; 8904920600; 57205024859; 55493237600; 7409325705; 57194107730; 55663909700; 57192516634; 25929939400; 36487993300; 56540123400; 7202560711 | hrsz@kbri.re.kr;vomai_tram@yahoo.com;kdjehdwns123@naver.com;unnhwa@naver.com;jhyoon@kbri.re.kr;kijang1@kbri.re.kr;alice860413@naver.com;srk75@knu.ac.kr;junyeon88@gmail.com;chyang@dhu.ac.kr;vet202001@gmail.com;j-schoi@korea.ac.kr;kyungjin@dgist.ac.kr;esther1122@korea.ac.kr;kimhyun@korea.ac.kr;soolee@kbsi.re.kr;bjlee@ulsan.ac.kr;jwpark@ulsan.ac.kr;changman@kbri.re.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.51 | 2025-06-25 | 9 | 10 | Developmentally regulated GTP-binding protein 2 (DRG2); Dopamine release; Motor deficiency; Dopaminergic neurons; Motor coordination; Striatum | SYSTEM; PATHOPHYSIOLOGY; OVEREXPRESSION; EXPRESSION; DEPLETION; INTERVAL; GENES; MOUSE | Developmentally regulated GTP-binding protein 2 (DRG2); Dopamine release; Dopaminergic neurons; Motor coordination; Motor deficiency; Striatum | 3 o methyldopamine; 3,4 dihydroxyphenylacetic acid; binding protein; developmentally regulated GTP binding protein 2; epinephrine; glutamate decarboxylase 65; glutamate decarboxylase 67; homovanillic acid; levodopa; messenger RNA; serotonin; tyrosine 3 monooxygenase; unclassified drug; vesicular glutamate transporter 1; vesicular glutamate transporter 2; adult; animal cell; animal experiment; animal model; animal tissue; anxiety disorder; Article; behavior change; chromatography; computer assisted tomography; controlled study; cyclic potentiometry; dopamine release; dopaminergic nerve cell; electrical stimulus test; elevated plus maze test; female; fluorescence in situ hybridization; genotype phenotype correlation; growth retardation; hippocampal CA3 region; hippocampus; hypothalamus; immunohistochemistry; locomotion; male; motor coordination; motor dysfunction; mouse; neurotransmitter release; nigroneostriatal system; nonhuman; nucleus accumbens; parabrachial nucleus; postnatal development; protein expression; real time polymerase chain reaction; rotarod test; single drug dose; skeleton malformation; spatial learning; striate cortex; substantia nigra; thalamus; ventral tegmentum; Western blotting; young adult | English | 2020 | 2020-01-01 | 10.3390/ijms21010060 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Eckol Alleviates Intestinal Dysfunction during Suckling-to-Weaning Transition via Modulation of PDX1 and HBEGF | Maintaining intestinal health in livestock is critical during the weaning period. The precise mechanisms of intestinal dysfunction during this period are not fully understood, although these can be alleviated by phlorotannins, including eckol. This question was addressed by evaluating the changes in gene expression and intestinal function after eckol treatment during suckling-to-weaning transition. The biological roles of differentially expressed genes (DEGs) in intestinal development were investigated by assessing intestinal wound healing and barrier functions, as well as the associated signaling pathways and oxidative stress levels. We identified 890 DEGs in the intestine, whose expression was altered by eckol treatment, including pancreatic and duodenal homeobox (PDX)1, which directly regulate heparin-binding epidermal growth factor-like growth factor (HBEGF) expression in order to preserve intestinal barrier functions and promote wound healing through phosphoinositide 3-kinase (PI3K)/AKT and P38 signaling. Additionally, eckol alleviated H2O2-induced oxidative stress through PI3K/AKT, P38, and 5'-AMP-activated protein kinase (AMPK) signaling, improved growth, and reduced oxidative stress and intestinal permeability in pigs during the weaning period. Eckol modulates intestinal barrier functions, wound healing, and oxidative stress through PDX/HBEGF, and improves growth during the suckling-to-weaning transition. These findings suggest that eckol can be used as a feed supplement in order to preserve the intestinal functions in pigs and other livestock during this process. | Lee, Sang In; Kim, In Ho | Kyungpook Natl Univ, Dept Anim Biotechnol, Sangju 37224, South Korea; Dankook Univ, Dept Anim Resource & Sci, Chungcheongnam Do 330714, Cheonan Si, South Korea | ; Kim, Ju-Hyoung/N-1450-2019 | 57203597336; 36050641300 | silee78@knu.ac.kr;inhokim@dankook.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 13 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.14 | 2025-06-25 | 5 | 5 | barrier function; eckol; HBEGF; ethanol extract of driedE; cava | GROWTH-FACTOR; HB-EGF; BARRIER FUNCTION; ECKLONIA-CAVA; IN-VITRO; OXIDATIVE STRESS; GENE-EXPRESSION; MURINE MODEL; CELLS; PHLOROGLUCINOL | Barrier function; Eckol; Ethanol extract of dried E. cava; HBEGF | Animals; Animals, Suckling; Cell Line; Dioxins; Gene Expression Regulation, Developmental; Heparin-binding EGF-like Growth Factor; Homeodomain Proteins; Intestinal Diseases; Intestinal Mucosa; Intestines; MAP Kinase Signaling System; Oxidative Stress; Signal Transduction; Sus scrofa; Trans-Activators; Weaning; Wound Healing; algal extract; eckolina cava extract; epinephrine; gelatinase B; glutathione; glutathione peroxidase; heparin binding epidermal growth factor; hydrocortisone; malonaldehyde; noradrenalin; phosphatidylinositol 3 kinase; reactive oxygen metabolite; small interfering RNA; stress hormone; superoxide dismutase; transcription factor Nrf2; transcription factor PDX 1; tumor necrosis factor; unclassified drug; vascular cell adhesion molecule 1; dioxin; eckol; heparin binding epidermal growth factor; homeodomain protein; pancreatic and duodenal homeobox 1 protein; transactivator protein; AMPK signaling; animal cell; Article; blood sampling; cell culture; cell migration assay; cell proliferation; controlled study; Ecklonia cava; electric resistance; enteropathy; enzyme linked immunosorbent assay; fluorescence microscopy; gene expression; gene expression profiling; gene silencing; growth; high performance liquid chromatography; high throughput sequencing; hydrocortisone blood level; immunofluorescence; intestine function; intestine mucosa permeability; IPEC-J2 cell line; luciferase assay; MAPK signaling; modulation; nonhuman; oxidative stress; Pi3K/Akt signaling; pig; real time polymerase chain reaction; signal transduction; suckling animal; weaning; Western blotting; wound healing; animal; cell line; drug effect; enteropathy; gene expression regulation; genetics; growth, development and aging; intestine; intestine mucosa; metabolism; suckling animal | English | 2020 | 2020-07 | 10.3390/ijms21134755 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Experimental Animal Model Systems for Understanding Salivary Secretory Disorders | Salivary secretory disorders are life-disrupting pathologic conditions with a high prevalence, especially in the geriatric population. Both patients and clinicians frequently feel helpless and get frustrated by the currently available therapeutic strategies, which consist mainly of palliative managements. Accordingly, to unravel the underlying mechanisms and to develop effective and curative strategies, several animal models have been developed and introduced. Experimental findings from these models have contributed to answer biological and biomedical questions. This review aims to provide various methodological considerations used for the examination of pathological fundamentals in salivary disorders using animal models and to summarize the obtained findings. The information provided in this review could provide plausible solutions for overcoming salivary disorders and also suggest purpose-specific experimental animal systems. | Kim, Ji-Youn; An, Chang-Hyeon; Kim, Jae-Young; Jung, Jae-Kwang | Gachon Univ, Coll Hlth Sci, Dept Dent Hyg, Incheon 21936, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Radiol, IHBR, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Biochem, IHBR, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Med, IHBR, 2177 Dalgubeol Daero, Daegu 41940, South Korea | ; Kim, Ji-Youn/A-5779-2017 | 57157491000; 17134437600; 56812734700; 55970994400 | hoho6434@gachon.ac.kr;chan@knu.ac.kr;jykim91@knu.ac.kr;widenmy@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 21 | 22 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.19 | 2025-06-25 | 15 | 18 | animal experimental model; salivary dysfunction; salivary gland; therapeutic strategies | RAT PAROTID-GLAND; ACINAR-CELL REGENERATION; SUBMANDIBULAR-GLAND; MYOEPITHELIAL CELLS; RADIATION-INJURY; DUCT LIGATION; STEM-CELLS; IONIZING-RADIATION; DOWN-REGULATION; INDUCED DAMAGE | Animal experimental model; Salivary dysfunction; Salivary gland; Therapeutic strategies | Animals; Disease Models, Animal; Humans; Ligation; Radiation Injuries, Experimental; Saliva; Salivary Ducts; Salivary Gland Diseases; Salivary Glands; caspase 3; protein p53; animal experiment; animal model; cancer radiotherapy; cell damage; clinical protocol; feline model; head and neck tumor; immunohistochemistry; Medline; microvasculature; monkey model; mouse; nonhuman; ovine model; pathogenesis; porcine model; radiation dose; radiation injury; radiosensitivity; rat; Review; salivary gland disease; animal; disease model; experimental radiation injury; human; ligation; pathology; pathophysiology; physiology; saliva; salivary gland; salivary gland disease; salivary gland duct; surgery | English | 2020 | 2020-11 | 10.3390/ijms21228423 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Facilitation of Bone Healing Processes Based on the Developmental Function of Meox2 in Tooth Loss Lesion | In the present study, we examined the bone healing capacity of Meox2, a homeobox gene that plays essential roles in the differentiation of a range of developing tissues, and identified its putative function in palatogenesis. We applied the knocking down of Meox2 in human periodontal ligament fibroblasts to examine the osteogenic potential of Meox2. Additionally, we applied in vivo periodontitis induced experiment to reveal the possible application of Meox2 knockdown for 1 and 2 weeks in bone healing processes. We examined the detailed histomorphological changes using Masson's trichrome staining and micro-computed tomography evaluation. Moreover, we observed the localization patterns of various signaling molecules, including alpha-SMA, CK14, IL-1 beta, and MPO to examine the altered bone healing processes. Furthermore, we investigated the process of bone formation using immunohistochemistry of Osteocalcin and Runx2. On the basis of the results, we suggest that the knocking down of Meox2 via the activation of osteoblast and modulation of inflammation would be a plausible answer for bone regeneration as a gene therapy. Additionally, we propose that the purpose-dependent selection and application of developmental regulation genes are important for the functional regeneration of specific tissues and organs, where the pathological condition of tooth loss lesion would be. | Kim, Tae-Young; Park, Jae-Kyung; Prasad Aryal, Yam; Lee, Eui-Seon; Neupane, Sanjiv; Sung, Shijin; Pokharel, Elina; Yeon, Chang-Yeol; Kim, Ji-Youn; Jung, Jae-Kwang; Yamamoto, Hitoshi; An, Chang-Hyeon; Lee, Youngkyun; Sohn, Wern-Joo; Jang, Il-Ho; An, Seo-Young; Kim, Jae-Young | Kyungpook Natl Univ, Sch Dent, Dept Biochem, IHBR, Daegu 41940, South Korea; Pusan Natl Univ, Sch Dent, Inst Translat Dent Sci, Dept Oral Biochem & Mol Biol, Yangsan 50612, South Korea; SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA; Gachon Univ, Dept Dent Hyg, Coll Hlth Sci, Incheon 21936, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Med, IHBR, Daegu 41940, South Korea; Tokyo Dent Coll, Dept Histol & Dev Biol, Tokyo 1010061, Japan; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Radiol, IHBR, Daegu 41940, South Korea; Daegu Haany Univ, Premajor Cosmet & Pharmaceut, Gyongsan 38610, South Korea | Kim, Ji-Youn/A-5779-2017; Kim, Mi-Kyung/E-8682-2012 | 57208461628; 57202803380; 57202611163; 57202610354; 56183800400; 55787126100; 57220028220; 57211854259; 57157491000; 55970994400; 55725330600; 17134437600; 36062942200; 44161404800; 35083663000; 55258203200; 56812734700 | tae09290@gmail.com;dbgk15@naver.com;yamaryal@yahoo.com;euiseon3488@gmail.com;sanjiv.knu@gmail.com;shijin1432@gmail.com;elinapokharel1996@gmail.com;yhs2669@naver.com;hoho6434@gachon.ac.kr;widenmy@knu.ac.kr;hyamamoto@tdc.ac.jp;chan@knu.ac.kr;ylee@knu.ac.kr;wjsohn@dhu.ac.kr;ilho.jang@pusan.ac.kr;syan@knu.ac.kr;jykim91@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 22 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.36 | 2025-06-25 | 10 | 10 | periodontitis; signaling pathway; alveolar bone; bone formation; gene therapy | LIGATURE-INDUCED PERIODONTITIS; OSTEOGENIC DIFFERENTIATION; MESENCHYMAL INTERACTIONS; LIGAMENT; REVEALS; CELLS; MORPHOGENESIS; MECHANISMS; PALATE; GENES | Alveolar bone; Bone formation; Gene therapy; Periodontitis; Signaling pathway | Animals; Bone Regeneration; Fibroblasts; Gene Expression Regulation; Gene Knockdown Techniques; Homeodomain Proteins; Humans; Male; Mice; Periodontal Ligament; Signal Transduction; Tooth Loss; alpha smooth muscle actin; cytokeratin 14; homeodomain protein; interleukin 1beta; meox2 protein; myeloperoxidase; osteocalcin; small interfering RNA; transcription factor RUNX2; unclassified drug; homeodomain protein; MEOX2 protein, human; Meox2 protein, mouse; adult; animal experiment; Article; bone regeneration; controlled study; fibroblast; fracture healing; gene knockdown; gene therapy; human; human tissue; immunohistochemistry; in vitro study; in vivo study; male; micro-computed tomography; mouse; nonhuman; ossification; osteoblast; periodontal disease; periodontal ligament; periodontitis; protein function; staining; tissue regeneration; tooth development; tooth root; tooth socket; animal; bone regeneration; gene expression regulation; genetics; metabolism; periodontal disease; signal transduction | English | 2020 | 2020-11 | 10.3390/ijms21228701 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | GSK-3β-Targeting Fisetin Promotes Melanogenesis in B16F10 Melanoma Cells and Zebrafish Larvae through β-Catenin Activation | Fisetin is found in many fruits and plants such as grapes and onions, and exerts anti-inflammatory, anti-proliferative, and anticancer activity. However, whether fisetin regulates melanogenesis has been rarely studied. Therefore, we evaluated the effects of fisetin on melanogenesis in B16F10 melanoma cell and zebrafish larvae. The current study revealed that fisetin slightly suppressed in vitro mushroom tyrosinase activity; however, molecular docking data showed that fisetin did not directly bind to mushroom tyrosinase. Unexpectedly, fisetin significantly increased intracellular and extracellular melanin production in B16F10 melanoma cells regardless of the presence or absence of alpha-melanocyte stimulating hormone (alpha-MSH). We also found that the expression of melanogenesis-related genes such as tyrosinase and microphthalmia-associated transcription factor (MITF), were highly increased 48 h after fisetin treatment. Pigmentation of zebrafish larvae by fisetin treatment also increased at the concentrations up to 200 mu M and then slightly decreased at 400 mu M, with no alteration in the heart rates. Molecular docking data also revealed that fisetin binds to glycogen synthase kinase-3 beta (GSK-3 beta). Therefore, we evaluated whether fisetin negatively regulated GSK-3 beta, which subsequently activates beta-catenin, resulting in melanogenesis. As expected, fisetin increased the expression of beta-catenin, which was subsequently translocated into the nucleus. In the functional assay, FH535, a Wnt/beta-catenin inhibitor, significantly inhibited fisetin-mediated melanogenesis in zebrafish larvae. Our data suggested that fisetin inhibits GSK-3 beta, which activates beta-catenin, resulting in melanogenesis through the revitalization of MITF and tyrosinase. | Molagoda, Ilandarage Menu Neelaka; Karunarathne, Wisurumuni Arachchilage Hasitha Maduranga; Park, Sang Rul; Choi, Yung Hyun; Park, Eui Kyun; Jin, Cheng-Yun; Yu, Haiyang; Jo, Wol Soon; Lee, Kyoung Tae; Kim, Gi-Young | Jeju Natl Univ, Dept Marine Life Sci, Jeju 63243, South Korea; Dong Eui Univ, Coll Oriental Med, Dept Biochem, Busan 47227, South Korea; Kyungpook Natl Univ, Sch Dent, Inst Hard Tissue & Biotooth Regenerat, Dept Oral Pathol & Regenerat Med, Daegu 41940, South Korea; Zhengzhou Univ, Inst Drug Discovery & Dev, Sch Pharmaceut Sci, Zhengzhou, Henan 450001, Peoples R China; Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin 300193, Peoples R China; Dong Nam Inst Radiol & Med Sci, Dept Res Ctr, Busan 619953, South Korea; Natl Inst Forest Sci, Forest Biomat Res Ctr, Jinju 52817, South Korea | ; Haiyang, Yu/ACP-8009-2022; Karunarathne, Hasitha/AAQ-7562-2020; Kim, Kyoung-Sook/A-7768-2017; Molagoda, Neelaka/ABE-4537-2021 | 57199421710; 57201976006; 55450526300; 57211727369; 37071072400; 8634687200; 57188969739; 27168420300; 24448367700; 7403063801 | neelakagm2012@gmail.com;hasikarunarathne@gmail.com;srpark@jejunu.ac.kr;choiyh@deu.ac.kr;epark@knu.ac.kr;cyjin@zzu.edu.cn;yuhaiyang19830116@hotmail.com;sailorjo@dirams.re.kr;leekt99@korea.kr;immunkim@jejunu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 1.88 | 2025-06-25 | 39 | 35 | fisetin; melanogenesis; alpha-MSH; GSK-3 beta; beta-catenin | GLYCOGEN-SYNTHASE KINASE-3; GSK-3 INHIBITOR TIDEGLUSIB; MOLECULAR-MECHANISMS; IN-VITRO; MELANOCYTES; TYROSINASE; CANCER; PREVENTION; ALZHEIMERS; EXPRESSION | Fisetin; GSK-3β; Melanogenesis; α-MSH; β-catenin | alpha-MSH; Animals; beta Catenin; Cell Line, Tumor; Cell Survival; Flavonoids; Glycogen Synthase Kinase 3 beta; Larva; Melanins; Melanoma, Experimental; Mice; Microphthalmia-Associated Transcription Factor; Molecular Docking Simulation; Monophenol Monooxygenase; Pigmentation; Signal Transduction; Zebrafish; alpha intermedin; beta catenin; enzastaurin; fisetin; glycogen synthase kinase 3 inhibitor; glycogen synthase kinase 3beta; melanin; microphthalmia associated transcription factor; monophenol monooxygenase; phenylthiourea; protein inhibitor; protein translocase; tideglusib; tyrosine; Wnt protein; alpha intermedin; beta catenin; fisetin; flavonoid; glycogen synthase kinase 3beta; melanin; microphthalmia associated transcription factor; monophenol monooxygenase; animal cell; animal experiment; animal model; Article; B16-F10 cell line; cardiotoxicity; cell viability; controlled study; down regulation; drug mechanism; embryo; enzyme activity; flow cytometry; gene expression; heart rate; intracellular signaling; larva; melanogenesis; melanoma; molecular docking; mouse; MTT assay; nonhuman; reverse transcription polymerase chain reaction; stereomicroscopy; TYR gene; upregulation; Western blotting; Wnt signaling; zebra fish; animal; biosynthesis; cell survival; chemistry; drug effect; embryology; experimental melanoma; genetics; metabolism; pigmentation; signal transduction; tumor cell line | English | 2020 | 2020-01-01 | 10.3390/ijms21010312 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Identification of a Novel Gene,Osbht, in Response to High Temperature Tolerance at Booting Stage in Rice | Rice is one of the world's leading food crops, and over 90% of the world's rice production stems from Asia. In particular, an increase of 1 degrees C in the minimum temperature reduces the quantity of rice by 10%. Therefore, the development of rice varieties that can stably maintain the yield and quality of the rice even under these rapid climate changes is indispensable. In this study, we performed quantitative trait loci (QTL) mapping after treatment with heat stress during the booting stage in rice. We performed a QTL analysis using the Cheongcheong/Nagdong double haploid (CNDH) line and identified 19 QTLs during the 2 year analysis. Of these QTL regions, the 2.2 cM region of RM3709-RM11694 on chromosome 1 was shared among the six traits (heading date; culm length; panicle length; number of tiller; 1000 grain weight; and content of chlorophyll) examined. Rice Microsatellite (RM) 3709-RM11694 contained 27 high-temperature-tolerance candidate genes. Among the candidate genes,OsBHTshowed a different gene expression level between CNDH75, which is a high-temperature tolerant line, and CNDH11 which is a susceptible line. Although some existing high-temperature-tolerant genes have been reported,OsBHTcan be used more effectively for the development of heat tolerance in rice. | Park, Jae-Ryoung; Yang, Won-Tae; Kim, Doh-Hoon; Kim, Kyung-Min | Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Div Plant Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea; Dong A Univ, Coll Nat Resources & Life Sci, Busan 49315, South Korea | ; Kim, Kyung-Min Kim/C-7007-2014 | 57211205505; 56150341400; 7409766359; 34868260300 | icd92@naver.com;wtyang@dau.ac.kr;dhkim@dau.ac.kr;kkm@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 21 | 16 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.8 | 2025-06-25 | 15 | 17 | rice; booting stage; QTL; heat stress; abiotic | QUANTITATIVE TRAIT LOCI; HEAT-SHOCK-PROTEIN; OVER-EXPRESSION; STRESS; HSP90; COMPLEX; HSP70; DATABASE; ANTHESIS; CONFERS | Abiotic; Booting stage; Heat stress; QTL; Rice | Chromosomes, Plant; Oryza; Plant Proteins; Quantitative Trait Loci; Thermotolerance; binding protein; buffer; calcyclin; chaperone; chlorophyll; dimethylallyltransferase; glycosyltransferase; guanosine triphosphate; heat shock protein; phytohormone; protein kinase; protein kinase C; protein serine threonine kinase; transcriptase; transcription factor; plant protein; Agrobacterium tumefaciens; agronomic trait; Arabidopsis thaliana; Article; booting; centrifugation; fertilization; flowering; gene; gene mapping; heat stress; heat tolerance; measurement; nonhuman; open reading frame; osbht gene; panicle length; phenotype; phosphorylation; phylogenetic tree; plant defense; plant growth; protein denaturation; protein interaction; quantitative trait locus; reproducibility; RNA extraction; sequence analysis; temperature; Zea; genetics; growth, development and aging; metabolism; Oryza; plant chromosome; quantitative trait locus | English | 2020 | 2020-08 | 10.3390/ijms21165862 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Identifying Stabilin-1 and Stabilin-2 Double Knockouts in Reproduction and Placentation: A Descriptive Study | The placenta undergoes reconstruction at different times during fetal development to supply oxygen and nutrients required throughout pregnancy. To accommodate the rapid growth of the fetus, small spiral arteries undergo remodeling in the placenta. This remodeling includes apoptosis of endothelial cells that line spiral arteries, which are replaced by trophoblasts of fetal origin. Removal of dead cells is critical during this process. Stabilin-1 (Stab1) and stabilin-2 (Stab2) are important receptors expressed on scavenger cells that absorb and degrade apoptotic cells, and Stab1 is expressed in specific cells of the placenta. However, the role of Stab1 and Stab2 in placental development and maintenance remain unclear. In this study, we assessed Stab1 and Stab2 expression in the placenta and examined the reproductive capacity and placental development using a double-knockout mouse strain lacking both Stab1 and Stab2 (Stab1/2 dKO mice). Most pregnant Stab1/2 dKO female mice did not produce offspring and exhibited placental defects, including decidual hemorrhage and necrosis. Findings of this study offer the first description of the phenotypic characteristics of placentas and embryos of Stab1/2 dKO females during pregnancy, suggesting that Stab1 and Stab2 are involved in placental development and maintenance. | Kim, Soon-Young; Lee, Eun-Hye; Kim, Eun Na; Son, Woo-Chan; Kim, Yeo Hyang; Park, Seung-Yoon; Kim, In-San; Kim, Jung-Eun | Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Mol Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea; Univ Ulsan, Asan Med Ctr, Dept Pathol, Coll Med, Seoul 05505, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu 41944, South Korea; Kyungpook Natl Univ, Div Pediat Cardiol, Childrens Hosp, Daegu 41404, South Korea; Dongguk Univ, Sch Med, Dept Biochem, Gyeongju 38066, South Korea; Korea Inst Sci & Technol, Biomed Res Inst, Ctr Theragnosis, Seoul 02792, South Korea; Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 02841, South Korea | Kim, Eun Na/GVU-5478-2022; Kim, Sang/HSD-0402-2023 | 57204021560; 57189661699; 56076096200; 7005671988; 57032023800; 8627776300; 34770432800; 57209054588 | ksygood741@naver.com;coramdeoeh@nate.com;hk1997@naver.com;wcson@amc.seoul.kr;kimyhmd@knu.ac.kr;psyoon@dongguk.ac.kr;iskim14@kist.re.kr;kjeun@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 19 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.36 | 2025-06-25 | 7 | 8 | Stabilin-1; Stabilin-2; double knockout; placenta; decidua; hemorrhage | Decidua; Double knockout; Hemorrhage; Placenta; Stabilin-1; Stabilin-2 | Animals; Cell Adhesion Molecules, Neuronal; Endothelial Cells; Female; Fetal Development; Humans; Mice; Mice, Knockout; Oxygen; Placenta; Placentation; Pregnancy; Reproduction; Trophoblasts; Vascular Remodeling; oxygen; scavenger receptor; stabilin 1; stabilin 2; unclassified drug; nerve cell adhesion molecule; Stab1 protein, mouse; Stab2 protein, mouse; animal experiment; animal model; animal tissue; Article; bleeding; controlled study; decidua; descriptive research; embryo; embryo development; endothelium cell; female; fetus development; fibrin deposition; gene knockout; maternal mortality; mRNA expression level; necrosis; nonhuman; placenta development; placenta disorder; placenta tissue; pregnancy; progeny; quantitative analysis; reproduction; solutio placentae; trophoblast; animal; genetics; human; knockout mouse; metabolism; mouse; pathology; placenta; placenta development; reproduction; vascular remodeling | English | 2020 | 2020-10 | 10.3390/ijms21197235 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | In Situ Profiling of the Three Dominant Phyla Within the Human Gut Using TaqMan PCR for Pre-Hospital Diagnosis of Gut Dysbiosis | A microbial imbalance called dysbiosis leads to inflammatory bowel disease (IBD), which can include ulcerative colitis (UC). Fecal microbiota transplantation (FMT), a novel therapy, has recently been successful in treating gut dysbiosis in UC patients. For the FMT technique to be successful, the gut microbiota of both the healthy donors and UC patients must be characterized. For decades, next-generation sequencing (NGS) has been used to analyze gut microbiota. Despite the popularity of NGS, the cost and time constraints make it difficult to use in emergency services and activities related to the periodic monitoring of microbiota profile alterations. Hence, in this study, we developed a multiplex TaqMan qPCR assay (MTq-PCR) with novel probes to simultaneously determine the relative proportions of the three dominant microbial phyla in the human gut: Bacteroidetes, Firmicutes, and Proteobacteria. The relative proportions of the three phyla in fecal samples of either healthy volunteers or UC patients were similar when assessed NGS and the MTq-PCR. Thus, our MTq-PCR assay could be a practical microbiota profiling alternative for diagnosing and monitoring gut dysbiosis in UC patients during emergency situations, and it could have a role in screening stool from potential FMT donors. | Jo, Young Jae; Tagele, Setu Bazie; Huy Quang Pham; Jung, YeonGyun; Ibal, Jerald Conrad; Choi, SeungDae; Kang, Gi-Ung; Park, Sowon; Kang, Yunkoo; Kim, Seung; Koh, Hong; Shin, Jae-Ho | Kyungpook Natl Univ, Sch Appl Biosci, Coll Agr & Life Sci, Daegu 41566, South Korea; Yonsei Univ, Coll Med, Pediat Gastroenterol Hepatol & Nutr, Severance Pediat IBD Res Grp,Severance Childrens, Yonsei 06229, South Korea | ; Tagele, Setu Bazie/IYJ-1959-2023; Pham, Quang/AAB-3064-2022; Kim, Seung Woo/HOF-6634-2023; Ibal, Jerald/JYQ-0493-2024 | 57214743390; 57202007103; 57200503445; 57197833801; 57196117664; 57215651369; 57211635810; 57020161000; 55607051000; 57196230792; 35789948700; 57224125922 | dudwo7573@naver.com;setubazie@gmail.com;huypham@knu.ac.kr;jyg1076@knu.ac.kr;jerald.ibal@gmail.com;csd506@knu.ac.kr;gukang@knu.ac.kr;sowon81@yuhs.ac;hollycow@yuhs.ac;pedks@yuhs.ac;KHONG@yuhs.ac;jhshin@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.36 | 2025-06-25 | 8 | 8 | gut microbiota; next generation sequencing; primer design; qPCR; TaqMan probes; ulcerative colitis | REAL-TIME PCR; GEL-ELECTROPHORESIS ANALYSIS; ULCERATIVE-COLITIS; MICROBIOTA; PRIMERS; HEALTH; INFECTION; BACTERIA; THERAPY; DISEASE | Gut microbiota; Next generation sequencing; Primer design; QPCR; TaqMan probes; Ulcerative colitis | Bacteria; Colitis, Ulcerative; Dysbiosis; Fecal Microbiota Transplantation; Feces; Gastrointestinal Microbiome; High-Throughput Nucleotide Sequencing; Humans; Multiplex Polymerase Chain Reaction; Phylogeny; Sequence Analysis, DNA; Article; bacterial gene; Bacteroides fragilis; Bacteroidetes; biotechnological procedures; clinical article; Clostridium butyricum; comparative study; DNA extraction; dysbiosis; Escherichia coli; fecal microbiota transplantation; feces analysis; feces microflora; Firmicutes; gene amplification; gene sequence; high throughput sequencing; human; in situ profiling; in vitro study; inflammatory bowel disease; intestine flora; multiplex polymerase chain reaction; nonhuman; normal human; polymerase chain reaction; Proteobacteria; pyrosequencing; ulcerative colitis; bacterium; classification; DNA sequence; dysbiosis; feces; genetics; isolation and purification; microbiology; phylogeny; procedures | English | 2020 | 2020-03 | 10.3390/ijms21061916 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | In Vivo Optical Reporter-Gene-Based Imaging of Macrophage Infiltration of DNCB-Induced Atopic Dermatitis | This study was conducted to monitor the macrophage infiltration of atopic dermatitis (AD)-like skin lesions and to evaluate the effects of anti-AD therapeutic agents in immunocompetent mice via optical reporter-gene-based molecular imaging. The enhanced firefly luciferase (effluc)-expressing macrophage cell line (Raw264.7/effluc) was intravenously introduced into mice with 2,4-dinitrochlorobenzene (DNCB)-induced AD, followed by bioluminescent imaging (BLI). After in vivo imaging, AD-like skin lesions were excised, and ex vivo imaging and Western blotting were conducted to determine the presence of infused macrophages. Finally, the therapeutic effect of dexamethasone (DEX), an AD-modulating agent, was evaluated via macrophage tracking. In vivo imaging with BLI revealed the migration of the reporter macrophages to DNCB-induced AD-like skin lesions on day 1 post-transfer. The greatest recruitment was observed on day 3, and a decline in BLI signal was observed on day 14. Notably, in vivo BLI clearly showed the inhibition of the reporter macrophage infiltration of DNCB-induced AD-like skin lesions by DEX, which was consistent with the reduced AD symptoms observed in DEX-treated mice. We successfully visualized the macrophage migration to DNCB-induced AD-like skin lesions, proving the feasibility of macrophage imaging for evaluating AD-regulating drugs in living organisms. | Lee, Sang Bong; Park, Hyeonsoo; Lee, Jae-Eon; Kim, Kil-Soo; Jeon, Yong Hyun | Korea Inst Med Microrobot KIMIRo, Gwangju 61011, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 700721, South Korea; Res Ctr Stickus Corp, Haeundae Gu Jaesong Dong 1050-21, Busan 48054, South Korea; Pusan Natl Univ, Coll Nat Resources & Life Sci, Dept Biomat Sci, Life & Ind Convergence Res Inst, Pusan 50463, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 700721, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu 700721, South Korea | Jeon, Yong/N-6910-2019; Lee, Sang/I-8954-2014 | 57190304501; 57218703376; 56808832000; 35272034300; 16042453400 | sangbongyil@kimiro.re.kr;heonsoopark83@gmail.com;koof12@dgmif.re.kr;kslac@dgmif.re.kr;jeon9014@gmail.com; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 17 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.22 | 2025-06-25 | 8 | 9 | atopic dermatitis; reporter macrophages; enhanced firefly luciferase gene (effluc); cell tracking; bioluminescence imaging (BLI) | INHIBITS DEVELOPMENT; INFLAMMATION; MIGRATION; INSIGHTS | Atopic dermatitis; Bioluminescence imaging (BLI); Cell tracking; Enhanced firefly luciferase gene (effluc); Reporter macrophages | Administration, Intravenous; Animals; Cell Line; Dermatitis, Atopic; Dexamethasone; Dinitrochlorobenzene; Disease Models, Animal; Female; Genes, Reporter; Luciferases, Firefly; Macrophages; Mice; Mice, Inbred BALB C; Molecular Imaging; Optical Imaging; RAW 264.7 Cells; Treatment Outcome; 1 chloro 2,4 dinitrobenzene; antiinflammatory agent; cyclooxygenase 2; dexamethasone; inducible nitric oxide synthase; interleukin 1beta; interleukin 6; isoflurane; lipopolysaccharide; luciferin; mitogen activated protein kinase; nitric oxide; olive oil; protein kinase B; tumor necrosis factor; 1 chloro 2,4 dinitrobenzene; dexamethasone; firefly luciferase; animal cell; animal experiment; animal model; animal tissue; Article; atopic dermatitis; cell count; cell culture; cell infiltration; clinical assessment; clinical evaluation; controlled study; cytokine assay; down regulation; enzyme linked immunosorbent assay; female; flow cytometry; fluorescence activated cell sorting; fluorescence imaging; image analysis; immunoblotting; luciferase assay; macrophage infiltration; macrophage migration; macrophage tracking; molecular imaging; mouse; nonhuman; oxidative stress; protein expression; reporter gene; skin sensitization; therapy effect; upregulation; Western blotting; animal; atopic dermatitis; Bagg albino mouse; cell line; disease model; drug effect; genetics; intravenous drug administration; macrophage; metabolism; molecular imaging; RAW 264.7 cell line; reporter gene; transplantation; treatment outcome | English | 2020 | 2020-09 | 10.3390/ijms21176205 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals | 4-Hexyl resorcinol (4HR) is an organic compound and has been used in skin care application. 4HR is an M2-type macrophage activator and elevates vascular endothelial growth factor (VEGF) expression via the hypoxia-inducible factor (HIF)-independent pathway. As endothelial cells are important in wound healing, the human umbilical vein endothelial cells (HUVECs) were treated with 4HR, and changes in VEGF-A, -C, and transforming growth factor-beta 1 (TGF-beta 1) expression were investigated. The administration of 4HR increased the expression level of VEGF-A, -C, and TGF-beta 1. The application of TGF-beta 1 protein also increased the expression level of VEGF-A and -C. Knockdown with small interfering RNA (siRNA) targeting to TGF-beta 1 and the selective chemical inhibition (A83-01) to ALK5 confirmed the involvement of the TGF-beta signaling pathway in the 4-HR-mediated VEGFs expression. 4HR application in a burn model of diabetic rats demonstrated an increased level of angiogenic proteins with wound healing. Compared to sericin application, the 4HR application group showed more prominent capillary regeneration. Collectively, 4HR activated TGF-beta 1/ALK5/VEGFs signaling in endothelial cells and induced vascular regeneration and remodeling for wound healing. | Kim, Dae-Won; Jo, You-Young; Garagiola, Umberto; Choi, Je-Yong; Kang, Yei-Jin; Oh, Ji-Hyeon; Kim, Seong-Gon | Gangneung Wonju Natl Univ, Dept Oral Biochem, Coll Dent, Kangnung 28644, South Korea; Rural Dev Adm, Natl Inst Agr Sci, Sericultural & Apicultural Div, Wonju 55365, South Korea; Univ Milan, Sch Dent, Maxillofacial & Dent Unit, Biomed Surg & Oral Sci Dept, I-20122 Milan, Italy; Kyungpook Natl Univ, Korea Mouse Phenotyping Ctr KMPC, BK21 Plus KNU Biomed Convergence Program, Sch Biochem & Cell Biol,Skeletal Dis Anal Ctr, Daegu 41944, South Korea; Gangneung Wonju Natl Univ, Dept Oral & Maxillofacial Surg, Coll Dent, Kangnung 28644, South Korea | Choi, Je-Yong/AAR-7334-2021; Kim, Seong-Gon/AAF-7553-2020; Garagiola, Umberto/AAM-2220-2020 | 56194913400; 36019240900; 8583947500; 7501391068; 57211458783; 55957562000; 27171913700 | kimdw@gwnu.ac.kr;yyjo@korea.kr;umberto.garagiola@unimi.it;jechoi@knu.ac.kr;kyj292@hanmail.net;haruna348@naver.com;kimsg@gwnu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 21 | 10 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 1.59 | 2025-06-25 | 27 | 29 | 4-hexylresorcinol; HUVEC; diabetes mellitus; TGF-beta 1; angiogenesis | TRANSITION; EXPRESSION; INHIBITOR; MELLITUS; DELIVERY | 4-hexylresorcinol; Angiogenesis; Diabetes mellitus; HUVEC; TGF-β1 | Animals; Burns; Diabetes Mellitus, Experimental; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Macrophages; Rats; Receptor, Transforming Growth Factor-beta Type I; Resorcinols; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor C; Wound Healing; hexylresorcinol; sericin; transforming growth factor beta receptor 1; transforming growth factor beta1; vasculotropin; vasculotropin A; vasculotropin C; resorcinol; resorcinol derivative; small interfering RNA; TGFB1 protein, human; TGFBR1 protein, human; transforming growth factor beta1; VEGFC protein, human; animal experiment; animal model; animal tissue; Article; burn; capillary regeneration; confocal microscopy; controlled study; diabetes mellitus; gene expression; gene knockdown; glucose blood level; histology; human; human cell; HUVEC cell line; immunohistochemistry; male; nonhuman; rat; regeneration; signal transduction; thermography; vascular remodeling; Western blotting; wound healing; animal; burn; complication; disease model; drug effect; experimental diabetes mellitus; genetics; macrophage; metabolism; pathology; umbilical vein endothelial cell; wound healing | English | 2020 | 2020-05 | 10.3390/ijms21103473 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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