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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Arabidopsis retromer subunit AtVPS29 is involved in SLY1-mediated gibberellin signaling | Key messageRetromer protein AtVPS29 upregulates the SLY1 protein and downregulates the RGA protein, positively stimulating the development of the root meristematic zone, which indicates an important role of AtVPS29 in gibberellin signaling.AbstractIn plants, the large retromer complex is known to play roles in multiple development processes, including cell polarity, programmed cell death, and root hair growth in Arabidopsis. However, many of its roles in plant development remain unknown. Here, we show that Arabidopsis trimeric retromer protein AtVPS29 (vacuolar protein sorting 29) modulates gibberellin signaling. The SLEEPY1 (SLY1) protein, known as a positive regulator of gibberellic acid (GA) signaling, exhibited lower abundance in vps29-3 mutants compared to wild-type (WT) plants. Conversely, the DELLA repressor protein, targeted by the E3 ubiquitin ligase SCF (Skp, Cullin, F-box) complex and acting as a negative regulator of GA signaling, showed increased abundance in vps29-3 mutants compared to WT. The vps29-3 mutants exhibited decreased sensitivity to exogenous GA supply in contrast to WT, despite an upregulation in the expression of GA receptor genes within the vps29-3 mutants. In addition, the expression of the GA synthesis genes was downregulated in vps29-3 mutants, implying that the loss of AtVPS29 causes the downregulation of GA synthesis and signaling. Furthermore, vps29-3 mutants exhibited a reduced meristematic zone accompanied by a decreased cell number. Together, these data indicate that AtVPS29 positively regulates SLY1-mediated GA signaling and plant growth. | Min, Wang Ki; Kwon, Dae Hwan; Song, Jong Tae; Seo, Hak Soo | Seoul Natl Univ, Coll Agr & Life Sci, Dept Agr Forestry & Bioresources, Gwanak ro 200, Seoul 08826, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | 57797161600; 57216938492; 57797134000; 26642769200 | seohs@snu.ac.kr; | PLANT CELL REPORTS | PLANT CELL REP | 0721-7714 | 1432-203X | 43 | 2 | SCIE | PLANT SCIENCES | 2024 | 4.5 | 13.7 | 1.69 | 2025-05-07 | 3 | 3 | Retromer protein; AtVPS29; Gibberellin; Meristematic zone; SLY1 | DELLA PROTEIN; PLANT-GROWTH; GENE ENCODES; ROOT-GROWTH; RECEPTOR; COMPLEX; TARGETS; SLEEPY1; LIGASE; MUTANT | AtVPS29; Gibberellin; Meristematic zone; Retromer protein; SLY1 | Arabidopsis; Arabidopsis Proteins; Gene Expression Regulation, Plant; Gibberellins; Mutation; Repressor Proteins; Arabidopsis protein; gibberellin; repressor protein; Arabidopsis; gene expression regulation; genetics; metabolism; mutation | English | 2024 | 2024-02 | 10.1007/s00299-024-03144-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparative transcriptomic analysis of the nodulation-competent zone and inference of transcription regulatory network in silicon applied Glycine max [L.]-Merr. Roots | Key message The study unveils Si's regulatory influence by regulating DEGs, TFs, and TRs. Further bHLH subfamily and auxin transporter pathway elucidates the mechanisms enhancing root development and nodulation. Soybean is a globally important crop serving as a primary source of vegetable protein for millions of individuals. The roots of these plants harbour essential nitrogen fixing structures called nodules. This study investigates the multifaceted impact of silicon (Si) application on soybean, with a focus on root development, and nodulation employing comprehensive transcriptomic analyses and gene regulatory network. RNA sequence analysis was utilised to examine the change in gene expression and identify the noteworthy differentially expressed genes (DEGs) linked to the enhancement of soybean root nodulation and root development. A set of 316 genes involved in diverse biological and molecular pathways are identified, with emphasis on transcription factors (TFs) and transcriptional regulators (TRs). The study uncovers TF and TR genes, categorized into 68 distinct families, highlighting the intricate regulatory landscape influenced by Si in soybeans. Upregulated most important bHLH subfamily and the involvement of the auxin transporter pathway underscore the molecular mechanisms contributing to enhanced root development and nodulation. The study bridges insights from other research, reinforcing Si's impact on stress-response pathways and phenylpropanoid biosynthesis crucial for nodulation. The study reveals significant alterations in gene expression patterns associated with cellular component functions, root development, and nodulation in response to Si. | Mansoor, Sheikh; Tripathi, Pooja; Ghimire, Amit; Hamid, Saira; El-moniem, Diaa Abd; Chung, Yong Suk; Kim, Yoonha | Jeju Natl Univ, Dept Plant Resources & Environm, Jeju 63243, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Ohio State Univ, Dept Hort & Crop Sci, Columbus, OH USA; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Islamia Univ Sci & Technol, Watson Crick Ctr Mol Med, Pulwama, J&K, India; Arish Univ, Fac Environm Agr Sci, Dept Plant Prod, Genet Branch, Arish 45511, Egypt | ; Mansoor, Sheikh/AAK-1432-2020; Abd El Moneim, Diaa/AAY-7021-2021; ghimire, amit/KCK-1842-2024; Chung, Yong/V-6909-2019 | 57207764253; 57215084745; 57823220200; 59167885500; 59168134900; 36983850100; 57224866763 | yschung@jejunu.ac.kr;kyh1229@knu.ac.kr; | PLANT CELL REPORTS | PLANT CELL REP | 0721-7714 | 1432-203X | 43 | 7 | SCIE | PLANT SCIENCES | 2024 | 4.5 | 13.7 | 1.13 | 2025-05-07 | 2 | 3 | Soybean; Silicon (Si) application; Transcriptomic analysis; Nodulation; Root development; Transcription factors (TFs) | NITROGEN-FIXATION; NODULE FORMATION; ARABIDOPSIS; EXPRESSION; JASMONATE; GROWTH; BHLH; PLANTS; BIOSYNTHESIS; RESPONSES | Nodulation; Root development; Silicon (Si) application; Soybean; Transcription factors (TFs); Transcriptomic analysis | Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Regulatory Networks; Glycine max; Plant Proteins; Plant Root Nodulation; Plant Roots; Silicon; Transcription Factors; Transcriptome; plant protein; silicon; transcription factor; transcriptome; comparative study; gene expression profiling; gene expression regulation; gene regulatory network; genetics; growth, development and aging; metabolism; nodulation; plant root; soybean | English | 2024 | 2024-07 | 10.1007/s00299-024-03250-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Dietary sugar potentiates tobacco carcinogen-induced lung cancer development and progression by inducing the recruitment and pro-tumoral polarization of macrophages | Lee, H. Y.; Park, R. W. | Seoul Natl Univ, Coll Pharm, Seoul, South Korea; Kyungpook Natl Univ, Coll Med, Daegu, South Korea | EUROPEAN JOURNAL OF CANCER | EUR J CANCER | 0959-8049 | 1879-0852 | 211 | SCIE | ONCOLOGY | 2024 | 7.1 | 13.7 | 0 | English | 2024 | 2024-10 | 10.1016/j.ejca.2024.114679 | 바로가기 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | Reassessing the contribution of TOMATO AGAMOUS-LIKE1 to fruit ripening by CRISPR/Cas9 mutagenesis | Key message CRISPR/Cas9-editedTOMATO AGAMOUS-LIKE1(TAGL1) provided new insights into fruit ripening.TOMATO AGAMOUS LIKE 1 (TAGL1) has been identified as playing a key role in the process of tomato fruit development and ripening. We have re-evaluated the functions of TAGL1 using CRISPR/Cas9 mutagenesis. Three KO mutants contained frameshift mutations resulting in premature termination codons due to a 1 bp insertion. TAGL1-KO mutants exhibited dark immature fruits and orange ripening fruits. The fruit shape was characterized by a prominent pointed tip at the end and the pericarp thickness was significantly thinner. TAGL1-KO mutants showed reduced ethylene biosynthesis, increased firmness, and delayed onset of ripening. The chlorophyll content of TAGL1-KO mutants was higher in the mature green stage and the lycopene content of TAGL1-KO mutants in the ripening stage was lower compared to the WT. ACS2, ACS4, ACO1, ACO3, PG2a, PL, PME, EXP1, and PSY1 in the mutants were significantly down-regulated during ripening. Ripening fruits in the double mutant of rin and tagl1 showed a more extreme phenotype than the rin mutant suggesting that the double mutation acts synergistically during ripening. TAGL1-targeted mutagenesis by CRISPR/Cas9 strengthens its regulatory functions controlling ripening parameters and provides new insights into fruit ripening. | Jeon, Chanjeong; Chung, Mi-Young; Lee, Je Min | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Hort Sci, Daegu 41566, South Korea; Sunchon Natl Univ, Dept Agr Educ, Sunchon 57922, South Korea | Lee, Je/AAE-7496-2020; Lee, Je Min/F-9797-2014 | 58826120400; 24821361600; 8885729900 | jemin@knu.ac.kr; | PLANT CELL REPORTS | PLANT CELL REP | 0721-7714 | 1432-203X | 43 | 2 | SCIE | PLANT SCIENCES | 2024 | 4.5 | 13.7 | 3.38 | 2025-05-07 | 7 | 6 | Tomato; Fruit ripening; CRISPR-Cas9; Gene editing; TOMATO AGAMOUS-LIKE 1 | CRISPR-Cas9; Fruit ripening; Gene editing; Tomato; TOMATO AGAMOUS-LIKE 1 | CRISPR-Cas Systems; Fruit; Mutagenesis; Mutation; Solanum lycopersicum; CRISPR Cas system; fruit; genetics; mutagenesis; mutation; tomato | English | 2024 | 2024-02 | 10.1007/s00299-023-03105-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Application of sperm motion kinematics and motility-related proteins for prediction of male fertility | The selection of superior sires is paramount for enhancing the efficiency of animal production in the livestock industry. However, semen quality assessment still relies on conventional semen analysis techniques in both animals and humans. Despite extensive efforts to develop various biomarkers for more accurate and precise predictions of male fertility potential, more effective physiological indicators and advance potential biomarkers are needed. Herein, we aimed to develop new potential biomarkers related to sperm motion kinematics for male fertility prediction. We first evaluated sperm motion kinematic parameters and expression levels of sperm motility-related proteins of 30 Duroc boars. We then explored the correlation between litter size, sperm motion kinematics parameters, and sperm motility-related proteins. Progressive sperm motility (%), rapid sperm motility (%), slow sperm motility (%), straight-line velocity (mu m/s), linearity (%), beat cross frequency (Hz), mean angular displacement (degree), wobble (%) were correlated with litter size. Furthermore, the expression of axonemal dynein light intermediate polypeptide 1 (DNALI1) and radial spoke head protein 9 homolog (RSPH9) correlated with litter size. The overall accuracy exceeded 60% for predicting litter size using these sperm motion parameters and proteins. Notably, our study observed an increase in litter size after predicting litter size using these parameters and proteins. Thus, sperm motion kinematic parameters and protein expression, particularly of DNALI1 and RSPH9, could serve as new biomarkers for male fertility. These results may contribute to improved understanding of the mechanisms underlying sperm motility. | Bae, Jeong-Won; Hwang, Ju-Mi; Lee, Woo-Jin; Kim, Dae-Hyun; Yi, Jun Koo; Ha, Jae Jung; Oh, Dong Yep; Kwon, Woo -Sung | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, Gyeongsangbug D, South Korea; Chonnam Natl Univ, Dept Anim Sci, Gwangju 61186, South Korea; Hankyong Natl Univ, Sch Anim Life Convergence Sci, Anseong 17579, South Korea; Gyeongbuk Livestock Res Inst, Yeongju 36052, Gyeongsangbug D, South Korea; Kyungpook Natl Univ, Res Ctr Horse Ind, Sangju 37224, Gyeongsangbug D, South Korea | Kwon, Woo-Sung/J-6731-2019; Bae, Jeong-Won/AAH-4932-2021; Kwon, Woo-Sung/J-4391-2014 | 57211231093; 57217871526; 57377138800; 57211228843; 56182537200; 55848402300; 42861900800; 54383715800 | ody1234@korea.kr;wskwon@knu.ac.kr; | THERIOGENOLOGY | THERIOGENOLOGY | 0093-691X | 1879-3231 | 218 | SCIE | REPRODUCTIVE BIOLOGY;VETERINARY SCIENCES | 2024 | 2.5 | 13.8 | 1.97 | 2025-05-07 | 2 | 2 | Sperm motion kinematics; Sperm motility -related proteins; Prediction of male fertility | SEMEN ANALYSIS STILL; LITTER SIZE; ARTIFICIAL-INSEMINATION; QUALITY-ASSURANCE; BOAR SPERMATOZOA; MOVEMENT; TAIL | Prediction of male fertility; Sperm motility-related proteins; Sperm motion kinematics | Animals; Biomarkers; Biomechanical Phenomena; Fertility; Humans; Male; Semen; Semen Analysis; Sperm Motility; Spermatozoa; Swine; biological marker; animal; biomechanics; fertility; human; male; physiology; pig; semen analysis; sperm; spermatozoon; spermatozoon motility; veterinary medicine | English | 2024 | 2024-04-01 | 10.1016/j.theriogenology.2024.02.007 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Body shape concerns and behavioral intentions on eating disorders: a cross-sectional study of Chinese female university students using an extended theory of reasoned action model | Background Weight and body shape concerns have become increasingly common among adolescents. Chinese university students show a high risk of eating disorder behaviors. This study aims to analyze the moderating effect of BMI on the relationships between body shape, attitudes, subjective norms, and eating disorder behavioral intentions among Chinese female university students using the Theory of Reasoned Action (TRA) model. Methods A stratified random sample of 679 female Chinese university students (age, mean +/- SD = 19.792 +/- 1.007) participated in the study. The surveys comprised the Theory of Reasoned Action Questionnaire (TRA-Q) and the Body Shape Questionnaire (BS-Q) to assess their body shape concerns and behavioral intentions regarding eating disorders. Structural equation modeling was used to test the extended TRA model, with body shape as an additional predictor and BMI as a moderator. Results Body shape positively affected attitudes (beta = 0.444, p < 0.001), subjective norms (beta = 0.506, p < 0.001), and intentions (beta = 0.374, p < 0.001). BMI significantly moderated the relationships between attitudes (t = -3.012, p < 0.01), subjective norms (t = -2.678, p < 0.01), and body shapes (t = -4.485, p < 0.001) toward eating disorder intentions. Conclusion Body shape and BMI directly influence eating disorder behavioral intentions among Chinese female university students. The findings suggest that young Chinese women's eating disorder intentions are increasingly influenced by external factors related to body shape and BMI. | Zhao, Jingyi; Zhao, Jing; Yuan, Han; Gao, Zeng | Nanjing Inst Technol, Phys Educ Dept, Nanjing, Peoples R China; Guangdong Presch Normal Coll Maoming, Coll Educ Sci, Maoming, Peoples R China; Kyungpook Natl Univ, Dept Phys Educ, Daegu, South Korea; Xiangtan Univ, Dept Phys Educ, Xiangtan, Peoples R China; Univ Sains Malaysia, Sch Educ Studies, George Town, Pinang, Malaysia | Zhao, Jing-yi/K-3480-2012 | 57219712840; 59500201600; 58784951600; 59141458400 | wwzgaozeng@163.com; | FRONTIERS IN NUTRITION | FRONT NUTR | 2296-861X | 11 | SCIE | NUTRITION & DIETETICS | 2024 | 5.1 | 13.8 | 0 | 2025-05-07 | 0 | 0 | body shape concern; behavioral intention; eating disorders; female university students; theory of reasoned action | MASS INDEX; IMPAIRMENT | behavioral intention; body shape concern; eating disorders; female university students; theory of reasoned action | English | 2024 | 2024-12-24 | 10.3389/fnut.2024.1501536 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Changes in characteristics of spermatogonial stem cells in response to heat stress in stallions | Spermatogonial stem cells (SSCs) are essential for the maintenance of male fertility and survival of species. Environmental conditions, notably heat stress, have been identified as important causes of male infertility and have a negative impact on SSCs. Animals with cryptorchid testes (CT) are optimal models for the study of long-term heat stress-related changes in germ cells. The effect of heat stress on germ cells differs depending on the spermatogenesis stage. Thus, verifying whether the specific phase of spermatogenesis is dependent or independent of heat stress in stallions is important. We evaluated the heat stress-related response of SSCs by comparing the relative abundance of mRNA transcripts and expression patterns of the undifferentiated embryonic cell transcription factor 1 (UTF-1) and deleted in azoospermia-like (DAZL) in the seminiferous tubules of CT and normal testes (NT) of stallions using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), immunofluorescence, and western blotting. We also analyzed the relative abundance of mRNA of different proliferative markers, including minichromosome maintenance 2 (MCM2), marker of proliferation Ki-67 (MKI-67), and proliferating cell nuclear antigen (PCNA). Testicular tissues from four Thoroughbred unilateral cryptorchid postpubertal stallions were used in this study during the breeding season. The relative abundance of the mRNA transcripts of UTF-1 and MCM2 was significantly upregulated in the CT group than that of those in the NT group. In contrast, the relative abundance of the mRNA transcripts of DAZL was significantly downregulated in the CT group than that of those in the NT group. Western blot quantification showed that the relative intensity of UTF-1 protein bands was significantly higher, while that of DAZL protein bands was significantly lower in the CT group than in the NT group. Immunofluorescence studies showed that the number of germ cells immunostained with UTF-1 was significantly higher while immunostained with DAZL was significantly lower in the CT group than that in the NT group. The higher expression level of UTF-1 in the CT group shows that undifferentiated SSCs are not affected by long-term exposure to heat stress. These results also indicate that germ cells after differentiation phase are directly affected by heat-stress conditions, such as cryptorchidism, in stallions. | Shakeel, Muhammad; Yoon, Minjung | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Horse Compan & Wild Anim Sci, Sangju 37224, South Korea; Pir Mehr Ali Shah Arid Agr Univ, Fac Vet & Anim Sci, Dept Clin Studies, Rawalpindi 44000, Pakistan | 57209179360; 22137296500 | mjyoonemail@gmail.com; | THERIOGENOLOGY | THERIOGENOLOGY | 0093-691X | 1879-3231 | 224 | SCIE | REPRODUCTIVE BIOLOGY;VETERINARY SCIENCES | 2024 | 2.5 | 13.8 | 0 | 2025-05-07 | 1 | 2 | Cryptorchidism; Heat stress; Spermatogenesis; Fertility | EXPRESSION; EXERCISE; UTF1; RATS | Cryptorchidism; Fertility; Heat stress; Spermatogenesis | Adult Germline Stem Cells; Animals; Gene Expression Regulation; Heat-Shock Response; Horses; Hot Temperature; Male; RNA, Messenger; Spermatogenesis; Spermatogonia; Testis; messenger RNA; adult stem cell; animal; gene expression regulation; genetics; heat shock response; high temperature; horse; male; metabolism; physiology; spermatogenesis; spermatogonium; testis | English | 2024 | 2024-08 | 10.1016/j.theriogenology.2024.05.007 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects of a self-managed return to work intervention for colorectal cancer survivors: A prospective randomized controlled trial | Purpose: The present study aims to assess the efficacy of stage-matched, self-managed Return to Work (RTW) interventions in enhancing RTW outcomes among colorectal cancer (CRC) survivors. Methods: This trial, conducted in South Korea, enrolled 58 unemployed survivors of colorectal cancer. Participants were randomly assigned to either an experimental or a control group. The experimental group received a self-managed return-to-work intervention based on the trans-theoretical model, while the control group received an educational booklet. Assessments were conducted at baseline and at 3, 6, and 12 months to measure changes in various factors including return-to-work status and HRQOL. Results: In the experimental group, 28 participants were randomly assigned, while 30 individuals were allocated to the control group. The experimental group exhibited a higher proportion of individuals achieving RTW (64.5% vs 39.3%, p = 0.013) and demonstrated greater improvements in work ability (p = 0.001), RTW self-efficacy (p = 0.035), readiness for RTW in the prepared-for-action (p < 00.0001), uncertain maintenance (p = 0.033), and proactive maintenance (p < 00.0001) stages, quality of working life (p = 0.003), HRQOL (p < 0.05), and illness perception (p < 0.05) compared to the control group at the 12-month follow-up. Conclusions: Stage-matched self-managed RTW interventions incorporating TTM principles may effectively enhance RTW outcomes and work ability among CRC survivors. | Park, Soo Yeun; Lee, Myung Kyung | Kyungpook Natl Univ, Coll Nursing, Res Inst Nursing Sci, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Colorectal Canc Ctr, Daegu, South Korea; Res Inst Nursing Sci, Coll Nursing, 680 Gukchabosangro, Daegu 41944, South Korea | 40561578300; 40661513200 | psy-flower@daum.net;mlee@knu.ac.kr; | EUROPEAN JOURNAL OF ONCOLOGY NURSING | EUR J ONCOL NURS | 1462-3889 | 1532-2122 | 70 | SCIE;SSCI | NURSING;ONCOLOGY | 2024 | 2.7 | 13.8 | 0.64 | 2025-05-07 | 1 | 1 | Stage-matched; Self-management; Return to work; Colorectal cancer; Randomized controlled trial | BREAST-CANCER; ABILITY INDEX; TO-WORK; EXERCISE PROGRAM; HEALTH-CARE; EMPLOYMENT; DIAGNOSIS; UNEMPLOYMENT; RELIABILITY; VALIDATION | Colorectal cancer; Randomized controlled trial; Return to work; Self-management; Stage-matched | Adult; Cancer Survivors; Colorectal Neoplasms; Female; Humans; Male; Middle Aged; Prospective Studies; Quality of Life; Republic of Korea; Return to Work; Self Efficacy; Self-Management; adult; cancer survivor; colorectal tumor; controlled study; female; human; male; middle aged; prospective study; psychology; quality of life; randomized controlled trial; return to work; self care; self concept; South Korea | English | 2024 | 2024-06 | 10.1016/j.ejon.2024.102593 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Unveiling nurses' end-of-life care experiences: Moral distress and impacts | Background Nurses providing care to patients with end-of-life or terminal illnesses often encounter ethically challenging situations leading to moral distress. However, existing quantitative studies have examined moral distress using instruments that address general clinical situations rather than those specific to end-of-life care. Furthermore, qualitative studies have often been limited to participants from a single unit or those experiencing moral distress-induced circumstances. A comprehensive and integrated understanding of the overarching process of moral distress is vital to discern the unique circumstances surrounding end-of-life care and its consequential impacts.Research objectives To explore the moral distress experiences of nurses who are frequently involved in caring for patients with end-of-life or terminal illnesses and apply it to two existing theories: the model of moral distress and the ecological model.Research design A qualitative descriptive approach was employed.Participants and research context Seven focus group interviews involving 30 nurses were performed. The subsequent transcriptions underwent rigorous content analysis.Ethical considerations We obtained Institutional Review Board approval from a university. Focus group interviews were conducted with nurses who agreed to participate and signed the consent form.Findings The moral distress-inducing factors and nurses' perceived impact of moral distress were identified and categorized based on moral distress theories and ecological models. A total of 15 categories and 30 subcategories across the following 4 domains were derived: (1) intrapersonal, (2) interpersonal, (3) organizational, and (4) structural factors.Conclusions End-of-life-specific circumstances induced moral distress among nurses, with both negative and positive impacts identified. Effective organizational and policy support is essential to manage conflicts, form a healthy organizational culture, provide training, and prevent unnecessary expenses due to the negative consequences of moral distress. | Lee, Myung Nam; Kwon, So-Hi; Yu, Sujeong; Park, Sook Hyun; Kwon, Sinyoung; Kim, Cho Hee; Park, Myung-Hee; Choi, Sung Eun; Kim, Sanghee; Kim, Sujeong | Kangwon Natl Univ, Chunchon, South Korea; Kyungpook Natl Univ, Daegu, South Korea; Sangji Univ, Wonju, South Korea; Samsung Med Ctr, Seoul, South Korea; Gangdong Univ, Eumseong Gun, South Korea; Catholic Univ Kora, Seoul, South Korea; Korean Hosp & Palliat Nurses Assoc, Seoul, South Korea; Yonsei Univ, Seoul, South Korea; Catholic Univ Korea, Res Inst Hosp & Palliat Care, Coll Nursing, Dept Family Hlth Nursing, 222 Banpo Daero, Seoul 06591, South Korea | ; kim, chohee/DTS-0771-2022; Kim, Sanghee/HNS-3553-2023; Kim, Sujeong/HGF-3789-2022 | 57212172081; 57206416770; 12779987200; 43761619600; 56447655900; 57195584917; 59008973200; 58259677700; 37002927800; 57148924700 | kimsu@songeui.ac.kr; | NURSING ETHICS | NURS ETHICS | 0969-7330 | 1477-0989 | 31 | 8 | SSCI;SCIE | ETHICS;NURSING | 2024 | 2.7 | 13.8 | 2.84 | 2025-05-07 | 4 | 4 | End-of-life care; moral distress; nurses; terminal care; qualitative research | COVID-19; HEALTH | End-of-life care; moral distress; nurses; qualitative research; terminal care | Adult; Attitude of Health Personnel; Female; Focus Groups; Humans; Male; Middle Aged; Morals; Nurses; Qualitative Research; Stress, Psychological; Terminal Care; adult; ethics; etiology; female; health personnel attitude; human; information processing; male; mental stress; middle aged; morality; nurse; procedures; psychology; qualitative research; terminal care | English | 2024 | 2024-12 | 10.1177/09697330241246086 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation | Coronaviruses rely on host proteases to activate the viral spike protein, which facilitates fusion with the host cell membrane and the release of viral genomic RNAs into the host cell cytoplasm. The distribution of specific host proteases in the host determines the host, tissue, and cellular tropism of these viruses. Here, we identified the kallikrein (KLK) family member KLK5 as a major host protease secreted by human airway cells and exploited by multiple human betacoronaviruses. KLK5 cleaved both the priming (S1/S2) and activation (S2 ') sites of spike proteins from various human betacoronaviruses in vitro. In contrast, KLK12 and KLK13 displayed preferences for either the S2 ' or S1/S2 site, respectively. Whereas KLK12 and KLK13 worked in concert to activate SARS-CoV-2 and MERS-CoV spike proteins, KLK5 by itself efficiently activated spike proteins from several human betacoronaviruses, including SARS-CoV-2. Infection of differentiated human bronchial epithelial cells (HBECs) with human betacoronaviruses induced an increase in KLK5 that promoted virus replication. Furthermore, ursolic acid and other related plant-derived triterpenoids that inhibit KLK5 effectively suppressed the replication of SARS-CoV, MERS-CoV, and SARS-CoV-2 in HBECs and mitigated lung inflammation in mice infected with MERS-CoV or SARS-CoV-2. We propose that KLK5 is a pancoronavirus host factor and a promising therapeutic target for current and future coronavirus-induced diseases. | Kim, Hyunjoon; Kang, Yeonglim; Kim, Semi; Park, Dongbin; Heo, Seo-Young; Yoo, Ji-Seung; Choi, Isaac; Abishek, N. Monford Paul; Ahn, Jae-Woo; Yang, Jeong-Sun; Bak, Nayeon; Kim, Kyeong Kyu; Lee, Joo-Yeon; Choi, Young Ki | Korea Virus Res Inst, Inst Basic Sci, Ctr Study Emerging & Reemerging Viruses, Daejeon 34126, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Korea Natl Inst Hlth KNIH, Natl Inst Infect Dis, Ctr Emerging Virus Res, 187 Osongsaengmyeong 2 Ro, Cheongju 28160, Chungbuk, South Korea; Sungkyunkwan Univ SKKU, Sungkyun Convergence Inst, Dept Metabiohealth, Suwon 16419, South Korea | Kim, Hyunjoon/AAK-3154-2021; Yoo, Ji-Seung/KHD-6177-2024; Kim, Kyeong/ABH-1988-2020 | 57210863442; 57204844556; 56278569700; 58690212300; 59293532100; 59510752300; 59294337200; 56069550900; 58865416400; 8075425800; 59293851600; 7409315955; 7601455784; 57220741552 | choiki55@ibs.re.kr; | SCIENCE SIGNALING | SCI SIGNAL | 1945-0877 | 1937-9145 | 17 | 850 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2024 | 6.6 | 13.9 | 0 | 2025-05-07 | 2 | 1 | INHIBITORS; CLEAVAGE; ENTRY; FURIN; RNA; TRITERPENOIDS; CORONAVIRUSES; HEMAGGLUTININ; TMPRSS2; SERINE | Animals; Betacoronavirus; Coronavirus Infections; COVID-19; HEK293 Cells; Humans; Kallikreins; Lung; Mice; Middle East Respiratory Syndrome Coronavirus; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Virus Replication; arginylvalyllysylarginyl chloromethylketone; camostat; coronavirus spike glycoprotein; kallikrein; kallikrein 12; kallikrein 13; kallikrein 5; oleanolic acid; peptide chloromethyl ketone; triterpenoid; tumulosic acid; unclassified drug; ursolic acid; coronavirus spike glycoprotein; kallikrein; KLK5 protein, human; spike protein, SARS-CoV-2; animal experiment; animal model; animal tissue; Article; Betacoronavirus; cell differentiation; controlled study; Coronavirus infection; female; HBEC cell line (bronchial epithelium); human; human cell; in vitro study; in vivo study; Middle East respiratory syndrome coronavirus; mouse; nonhuman; protein activation; protein cleavage; protein modification; SARS coronavirus; Severe acute respiratory syndrome coronavirus 2; virostatic activity; virus inhibition; virus pathogenesis; virus pneumonia; virus replication; animal; Betacoronavirus; coronavirus disease 2019; Coronavirus infection; genetics; HEK293S cell line; lung; metabolism; physiology; Severe acute respiratory syndrome coronavirus 2; virology | English | 2024 | 2024-08-20 | 10.1126/scisignal.adn3785 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | 2D/2D interface engineering of NiCrFe-layered double hydroxide-MXene hybrid architecture for extrinsic supercapacitors | The mesoporous hybrid architecture of MXene and NiCrFe-layered double hydroxide (NCF-LDH) can significantly enhance the electrochemical performance of pristine NCF-LDH. In this study, a NiCrFe-LDH-MXene (NCFM) hybrid structure is synthesized through the self-assembly of exfoliated NCF-LDH and MXene nano- sheets. The 2D/2D NCFM hybrid architecture displays expanded surface area, interconnected porous morphology, and intimate coupling between nanosheets. This unique architecture, along with strong interfacial interactions and synergistic effects between MXene and NCF-LDH nanosheets, greatly improves electrical conductivity and increases the number of active sites accessible to electrolytes. Moreover, the hybrid architecture prevents self-aggregation and restacking of the NCF-LDH and MXene nanosheets, ensuring full exposure of the active sites. Due to this unique 2D/2D hybrid architecture, the NCFM hybrid demonstrates an excellent specific capacity of 1082C g(-1) at a current density of 1 A g(-1). Furthermore, the solid-state supercapacitor constructed using NCF-LDH as the battery-type electrode and activated carbon as the capacitive electrode achieves a notable energy density of 62 Wh kg(-1) at a power density of 0.8 kW kg(-1). Additionally, the supercapacitor exhibits an outstanding capacitance retention rate of 86 % after 11,000 cycles at 8 A g(-1). These exceptional findings encourage further investigation into such promising 2D/2D hybrid structures with excellent charge storage capabilities and microstructural characteristics for developing next-generation energy storage systems. | Padalkar, Navnath S.; Shingade, Jayshri A.; Katkar, Pranav K.; Park, Jinyoung; Park, Jong Pil | Chung Ang Univ, Dept Food Sci & Technol, Anseong 17546, South Korea; D Y Patil Educ Soc Deemed be Univ, Ctr Interdisciplinary Res, Kolhapur 416006, India; Gachon Univ, Dept Chem & Biol Engn, 1342 Seongnam Daero, Seongnam 13120, South Korea; Kyungpook Natl Univ, Dept Polymer Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea | ; padalkar, navnath/LKJ-2372-2024; Katkar, Pranav/X-8030-2018 | 57216288668; 59347369600; 57204708369; 57286293400; 9270334400 | jinpark@knu.ac.kr;jppark@cau.ac.kr; | JOURNAL OF ENERGY STORAGE | J ENERGY STORAGE | 2352-152X | 2352-1538 | 101 | SCIE | ENERGY & FUELS | 2024 | 9.8 | 14.0 | 0.56 | 2025-05-07 | 4 | 4 | Interface engineering; Nanosheet; Architecture; NiCrFe-layered double hydroxide; Solid-state extrinsic supercapacitor; MXene | CARBIDE MXENE; NANOSHEETS; ELECTRODE | Architecture; Interface engineering; MXene; Nanosheet; NiCrFe-layered double hydroxide; Solid-state extrinsic supercapacitor | Capacitor storage; Interfaces (materials); Nanosheets; Selenium compounds; Silicon compounds; Solid electrolytes; Solid-State Batteries; Electrochemical performance; Hybrid architectures; Hybrid structure; Interface engineering; Layered-double hydroxides; Mesoporous hybrids; Mxene; Nicrfe-layered double hydroxide; Solid-state extrinsic supercapacitor; Synthesised; Self assembly | English | 2024 | 2024-11-10 | 10.1016/j.est.2024.113969 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A critical review of different types of biochar-based catalysts and mechanisms in advanced oxidation processes for organic contaminants removal | Biochar (BC)-assisted advanced oxidation processes (AOPs) offer an unprecedented opportunity for organic contaminant remediation because of their high efficiency and environmental friendliness. However, the catalytic mechanisms for different BC-assisted AOPs need to be further explored, considering that each type of BC catalyst possesses unique active sites and physicochemical properties, which influence associated catalytic mechanisms. Most existing reviews have focused on individual types of BC or AOPs, especially in relevance to mechanism. Furthermore, there is a lack of detailed understanding of the catalytic mechanisms derived from the various active sites in BC catalysts which restrict the ease of evolving design strategy for ideal catalytic structures. Therefore, this review evaluates and presents the current knowledge on the relevant active sites of BC-based catalysts, feasibility for generation of reactive oxygen species, and the associated catalytic mechanisms involved in AOPs for the four most known types of BC, which are pristine BC (P-BC), non-metallic heteroatomdoped BC (NM-BC), metal BC composite (M-BC), and metal and heteroatom co-doped BC (MHC-BC) catalysts. The factors influencing the catalytic properties of BC materials are systematically discussed, while highlighting the relationships with associated mechanisms and synthetic conditions. Finally, the current challenges and prospects associated with BC-AOPs are outlined. Overall, this review aims to inspire the rational design of more advanced BC-based catalysts for AOPs in the remediation of organic contaminants in the environment. | Zeng, Zijun; Umeh, Anthony; Iyengar, Gopalan Anantha; Qi, Fangjie; Naidu, Ravi | Univ Newcastle, Global Ctr Environm Remediat GCER, Callaghan, NSW 2308, Australia; Univ Newcastle, crcCARE, Callaghan, NSW 2308, Australia; Kyungpook Natl Univ, Intelligent Construct Automat Ctr, Daegu 41566, South Korea; Chinese Acad Sci, Nanjing Inst Soil Sci, 71 Beijing East Rd, Nanjing 210008, Jiangsu, Peoples R China | Naidu, Ravi/F-5927-2012; Zeng, Zijun/AFX-2324-2022 | 58563992700; 57191518084; 36672971200; 56661755600; 7102091779 | algopal99@gmail.com;ravi.naidu@newcastle.edu.au; | JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING | J ENVIRON CHEM ENG | 2213-2929 | 2213-3437 | 12 | 6 | SCIE | ENGINEERING, CHEMICAL;ENGINEERING, ENVIRONMENTAL | 2024 | 7.2 | 14.0 | 0.45 | 2025-05-07 | 5 | 6 | Biochar types; Catalytic mechanism; Active sites; Advanced oxidation process; Organic contaminants; Influencing factors | PERSISTENT FREE-RADICALS; NITROGEN-DOPED BIOCHAR; IRON-OXIDE; ACTIVATION; CARBON; PERSULFATE; PEROXYMONOSULFATE; DEGRADATION; REDUCTION; PYROLYSIS | Active sites; Advanced oxidation process; Biochar types; Catalytic mechanism; Influencing factors; Organic contaminants | 'current; Active site; Advanced Oxidation Processes; Biochar; Biochar type; Catalytic mechanisms; Heteroatoms; Influencing factor; Organic contaminant; ]+ catalyst; Catalytic oxidation | English | 2024 | 2024-12 | 10.1016/j.jece.2024.114262 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A practical semi-empirical model for predicting the SoH of lithium-ion battery: A novel perspective on short-term rest | In this paper, the semi-empirical battery degradation prediction model proposed considers electrochemical degradation characteristics and represents degradation effects under various conditions, including different states of charge (SoC) areas. This model is specifically designed to address degradation during cycling and shortterm rest periods in lithium-ion batteries using liquid electrolytes. Cycle aging incorporates the impact of solid electrolyte interphase (SEI) growth, a known dominant factor, and the model for short-term resting periods captures potential aging impacts on subsequent cycles due to internal material concentration gradients, moving away from the traditionally used calendar life approach. The derivation of the model presented in this paper is based on 14 data sets under different SoC conditions and 8 data sets under various Crates, explaining the degradation effects at 10 % SoC intervals and three different Crate points. Moreover, the model's performance was validated through capacity prediction for two data sets experimented with dynamic operational schedules of actual energy storage systems (ESS), including various conditions. The results showed a root mean square error (RMSE) of 0.564 and a mean absolute percentage error (MAPE) of 0.346. The superiority of this model is demonstrated by comparing its performance with four other types of degradation models derived through the same process in the validation data. | Park, Jeongju; Jin, Yuwei; Kam, Woochan; Han, Sekyung | Kyungpook Natl Univ, Elect & Elect Engn, Daegu 41566, South Korea | Jin, Yuwei/JXN-9217-2024 | 57964023800; 57212253293; 58847545300; 36023785800 | skhan@knu.ac.kr; | JOURNAL OF ENERGY STORAGE | J ENERGY STORAGE | 2352-152X | 2352-1538 | 96 | SCIE | ENERGY & FUELS | 2024 | 9.8 | 14.0 | 2.25 | 2025-05-07 | 10 | 11 | Lithium-ion battery; State of health prediction; Aging cost evaluation; Semi-empirical model; Solid electrolyte interphase | SOLID-ELECTROLYTE INTERPHASE; AGING MECHANISMS; CAPACITY FADE; TEMPERATURE; CHARGE; STATE | Aging cost evaluation; Lithium-ion battery; Semi-empirical model; Solid electrolyte interphase; State of health prediction | Battery management systems; Digital storage; Ions; Lithium-ion batteries; Mean square error; Solid electrolytes; Solid-State Batteries; Aging cost evaluation; Condition; Cost evaluations; Data set; Degradation effect; Semiempirical models; Solid electrolyte interphase; State of health; State of health prediction; States of charges; Forecasting | English | 2024 | 2024-08-15 | 10.1016/j.est.2024.112659 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Assessing the Labeling Information on Drugs Associated With Suicide Risk: Systematic Review | Background: Drug-induced suicide (DIS) is a severe adverse drug reaction (ADR). Although clinical trials have provided evidence on DIS, limited investigations have been performed on rare ADRs, such as suicide. Objective: We aimed to systematically review case reports on DIS to provide evidence-based drug information. Methods: We searched PubMed to obtain case reports regarding DIS published until July 2021. Cases resulting from drugs that are no longer used or are nonapproved, substance use, and suicidal intentions were excluded. The quality of each case report was assessed using the CASE (Case Reports) checklist. We extracted data regarding demographics, medication history, suicide symptoms, and symptom improvement and evaluated the causality of DIS using the Naranjo score. Furthermore, to identify the potential suicidal risk of the unknown drugs, we compared the results of the causality assessment with those of the approved drug labels. Results: In 83 articles, we identified 152 cases involving 61 drugs. Antidepressants were reported as the most frequent causative drugs of DIS followed by immunostimulants. The causality assessment revealed 61 cases having possible, 89 cases having probable, and 2 cases having definite relationships with DIS. For approximately 85% of suspected drugs, the risk of suicidal ADRs was indicated on the approved label; however, the approved labels for 9 drugs, including lumacaftor/ivacaftor, doxycycline, clozapine, dextromethorphan, adalimumab, infliximab, piroxicam, paclitaxel, and formoterol, did not provide information about these risks. Conclusions: We found several case reports involving drugs without suicide risk information on the drug label. Our findings might provide valuable insights into drugs that may cause suicidal ADRs. | Jeon, Soo Min; Lim, Hyunjoo; Cheon, Hyo-bin; Ryu, Juhee; Kwon, Jin-Won | Jeju Natl Univ, Jeju Res Inst Pharmaceut Sci, Coll Pharm, Jeju, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu, South Korea; Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug D, 80 Daehak Ro, Daegu 41566, South Korea; Res Inst Pharmaceut Sci, 80 Daehak Ro, Dae 41566, South Korea | 57206855645; 58857293400; 57223131003; 57208255566; 16202951700 | jwkwon@knu.ac.kr; | JMIR PUBLIC HEALTH AND SURVEILLANCE | JMIR PUBLIC HLTH SUR | 2369-2960 | 10 | SCIE;SSCI | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2024 | 3.9 | 14.0 | 0.71 | 2025-04-16 | 2 | 2 | suicide; adverse drug events; review; drug; mental health; systematic review; drug induced suicide; drug reaction; substance use; suicidal; medication; suicide symptoms; suicidal risk; drugs; adverse drug event | DEXTROMETHORPHAN ABUSE; DEPRESSION; CLOZAPINE; SCHIZOPHRENIA; ADALIMUMAB; IDEATION; BRAIN; ALPHA | adverse drug event; adverse drug events; drug; drug induced suicide; drug reaction; drugs; medication; mental health; review; substance use; suicidal; suicidal risk; suicide; suicide symptoms; systematic review | Case Reports as Topic; Doxycycline; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Suicidal Ideation; Suicide; doxycycline; adverse drug reaction; drug labeling; human; medical literature; suicidal ideation; suicide | English | 2024 | 2024 | 10.2196/49755 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Autophagy caused by oxidative stress promotes TGF-β1-induced epithelial-to-mesenchymal transition in human peritoneal mesothelial cells | Epithelial-to-mesenchymal transition (EMT) is one of the main causes of peritoneal fibrosis. However, the pathophysiological mechanisms of EMT, specifically its relationship with autophagy, are still unknown. This study aimed to evaluate the role of autophagy in transforming growth factor-beta 1 (TGF-beta 1)-induced EMT in human peritoneal mesothelial cells (HPMCs). Primary cultured HPMCs were treated with TGF-beta 1 (2 and 5 ng/mL) and changes in autophagy markers and the relationship between autophagy and EMT were evaluated. We also identified changes in EMT- and autophagy-related signaling pathways after autophagy and NADPH oxidase 4 (NOX4) inhibition. TGF-beta 1 increased the generation of NOX4 and reactive oxygen species (ROS) in HPMCs, resulting in mitochondrial damage. Treatment with GKT137831 (20 mu M), a NOX1/4 inhibitor, reduced ROS in the mitochondria of HPMC cells and reduced TGF-beta 1-induced mitochondrial damage. Additionally, the indirect inhibition of autophagy by GKT137831 (20 mu M) downregulated TGF-beta 1-induced EMT, whereas direct inhibition of autophagy using 3-methyladenine (3-MA) (2 mM) or autophagy-related gene 5 (ATG5) gene silencing decreased the TGF-beta 1-induced EMT in HPMCs. The suppressor of mothers against decapentaplegic 2/3 (Smad2/3), autophagy-related phosphoinositide 3-kinase (PI3K) class III, and protein kinase B (Akt) pathways, and mitogen-activated protein kinase (MAPK) signaling pathways, such as extracellular signal-regulated kinase (ERK) and P38, were involved in TGF-beta 1-induced EMT. Autophagy and NOX4 inhibition suppressed the activation of these signaling pathways. Direct inhibition of autophagy and its indirect inhibition through the reduction of mitochondrial damage by upstream NOX4 inhibition reduced EMT in HPMCs. These results suggest that autophagy could serve as a therapeutic target for the prevention of peritoneal fibrosis in patients undergoing peritoneal dialysis. | Oh, Se-Hyun; Yook, Ju-Min; Jung, Hee-Yeon; Choi, Ji-Young; Cho, Jang-Hee; Park, Sun-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Lim, Jeong-Hoon | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Div Nephrol,Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu, South Korea | Park, Sun-Hee/LMN-0033-2024; Kim, Yong-Lim/AGK-3172-2022; Cho, Jang-hee/ABD-3534-2020; Jung, Hee-Yeon/AFB-8578-2022; Lim, Jeong-Hoon/ABE-6003-2020 | 56053033900; 35110084800; 57196396467; 7501393222; 7403536291; 7501831741; 8558530700; 55633533600; 55360244300 | ylkim@knu.ac.kr;jh-lim@knu.ac.kr; | CELL DEATH & DISEASE | CELL DEATH DIS | 2041-4889 | 15 | 5 | SCIE | CELL BIOLOGY | 2024 | 9.6 | 14.0 | 1.39 | 2025-05-07 | 5 | 5 | MECHANISMS; DIALYSIS; INHIBITION; APOPTOSIS; NOX4 | Autophagy; Epithelial Cells; Epithelial-Mesenchymal Transition; Humans; Mitochondria; NADPH Oxidase 4; Oxidative Stress; Peritoneum; Pyrazolones; Pyridones; Reactive Oxygen Species; Signal Transduction; Transforming Growth Factor beta1; 3 methyladenine; autophagy related protein 5; beclin 1; messenger RNA; mitogen activated protein kinase; phosphatidylinositol 3 kinase; protein kinase B; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate oxidase 4; setanaxib; Smad2 protein; Smad3 protein; transforming growth factor beta1; uvomorulin; dipyrone; NOX4 protein, human; pyrazolone derivative; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate oxidase 4; setanaxib; TGFB1 protein, human; transforming growth factor beta1; Article; autophagosome; autophagy (cellular); cell viability; controlled study; down regulation; epithelial mesenchymal transition; gene silencing; human; human cell; mesothelium cell; mitochondrion; oxidative stress; oxygen consumption rate; peritoneal dialysis; peritoneal fibrosis; peritoneum; protein expression; real time polymerase chain reaction; RNA extraction; signal transduction; transmission electron microscopy; upregulation; drug effect; epithelium cell; genetics; metabolism; pathology; peritoneum; signal transduction | English | 2024 | 2024-05-28 | 10.1038/s41419-024-06753-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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