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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Letter | Acute Hyperglycemic Crises with Coronavirus Disease-19: Case Reports (Diabetes Metab J 2020;44: 349-53) | Kim, Na-Young; Ha, Eunyeong; Moon, Jun Sung; Lee, Yong-Hoon; Choi, Eun Young | Kyungpook Natl Univ, Div Endocrinol & Metab, Dept Internal Med, Kyungpook Natl Univ Hosp,Sch Med, Daegu, South Korea; Yeungnam Univ, Dept Internal Med, Coll Med, 170 Hyeonchung Ro, Daegu 42415, South Korea; Kyungpook Natl Univ, Div Pulm & Crit Care Med, Dept Internal Med, Kyungpook Natl Univ Hosp,Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea | 57201292256; 57216645230; 55261990400; 57199022948; 57190418295 | id0121@naver.com;letact@yu.ac.kr; | DIABETES & METABOLISM JOURNAL | DIABETES METAB J | 2233-6079 | 2233-6087 | 44 | 3 | SCIE | ENDOCRINOLOGY & METABOLISM | 2020 | 5.376 | 22.3 | 1.09 | 2025-06-25 | 4 | 7 | RECEPTOR; ACE2 | Betacoronavirus; Coronavirus; Coronavirus Infections; Humans; Pandemics; Pneumonia, Viral; 2,4 thiazolidinedione derivative; angiotensin converting enzyme 2; antidiabetic agent; bisoprolol; calcium channel blocking agent; carbapenem; furosemide plus spironolactone; glimepiride; glucagon like peptide 1 receptor agonist; hydroxymethylglutaryl coenzyme A reductase inhibitor; insulin; losartan; metformin; antibiotic therapy; case report; clinical article; continuous infusion; coronavirus disease 2019; diabetes mellitus; diabetic complication; drug withdrawal; dyslipidemia; false positive result; female; fever; human; hyperglycemia; hyperosmolarity; hypertension; intensive care unit; Note; polymerase chain reaction; protein expression; quarantine; reinfection; relapse; SARS coronavirus; scientific literature; Severe acute respiratory syndrome coronavirus 2; treatment interruption; upregulation; Betacoronavirus; Coronavirinae; Coronavirus infection; pandemic; virus pneumonia | English | 2020 | 2020-06 | 10.4093/dmj.2020.0129 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Can Habitual Exercise Help Reduce Serum Concentrations of Lipophilic Chemical Mixtures? Association between Physical Activity and Persistent Organic Pollutants | Background: Low-dose persistent organic pollutants (POPs), especially organochlorine pesticides (OCPs), have emerged as a new risk factor of many chronic diseases. As serum concentrations of POPs in humans are mainly determined by both their release from adipose tissue to circulation and their elimination from circulation, management of these internal pathways may be important in controlling the serum concentrations of POPs. As habitual physical activity can increase the elimination of POPs from circulation, we evaluated whether chronic physical activity is related to low serum POP concentrations. Methods: A cross-sectional study of 1,850 healthy adults (age >= 20 years) without cardio-metabolic diseases who participated in the US. National Health and Nutrition Examination Survey 1999 to 2004 was conducted. Information on moderate or vigorous leisure-time physical activity was obtained based on questionnaires. Serum concentrations of OCPs and polychlorinated biphenyls were investigated as typical POPs. Results: Serum concentrations of OCPs among physically active subjects were significantly lower than those among physically inactive subjects (312.8 ng/g lipid vs. 538.0 ng/g lipid, P<0.001). This difference was maintained after adjustment for potential confounders. When analyses were restricted to physically active subjects, there were small decreases in the serum concentrations of OCPs with increasing duration of physical activity, showing a curvilinear relationship over the whole range of physical activity (P-quadratic <0.001). In analyses stratified by age, sex, body mass index, and smoking status, a strong inverse association was similarly observed among all subgroups. Conclusion: Physical activity may assist in decreasing serum concentrations of lipophilic chemical mixtures such as OCPs. | Lee, Yu-Mi; Shin, Ji-Yeon; Kim, Se-A; Jacobs, David R., Jr.; Lee, Duk-Hee | Kyungpook Natl Univ, Sch Med, Dept Prevent Med, 680 Gukchaehosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Korea, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea; Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA | ; Jacobs, David/G-5405-2011 | 57075191600; 55567961600; 56311702800; 57200715827; 57211851121 | lee_dh@knu.ac.kr; | DIABETES & METABOLISM JOURNAL | DIABETES METAB J | 2233-6079 | 2233-6087 | 44 | 5 | SCIE | ENDOCRINOLOGY & METABOLISM | 2020 | 5.376 | 22.3 | 0.55 | 2025-06-25 | 11 | 14 | Adipose tissue; Complex mixtures; Environmental exposure; Environmental pollutants; Exercise; Organic chemicals; Pesticides; Polychlorinated biphenyls | ADIPOSE-TISSUE; INSULIN SENSITIVITY; WEIGHT-LOSS; OBESITY; PESTICIDES; MORTALITY; LIPOLYSIS; HEALTH; LEVEL | Adipose tissue; Organochlorine pesticides; Persistent organic pollutants; Physical activity; Polychlorinated biphenyls | Adult; Cross-Sectional Studies; Exercise; Female; Humans; Hydrocarbons, Chlorinated; Male; Middle Aged; Nutrition Surveys; Persistent Organic Pollutants; Young Adult; 1,1 dichloro 2,2 bis(4 chlorophenyl)ethylene; beta hexachlorocyclohexane; cholesterol; heptachlor epoxide; oxychlordane; polychlorinated biphenyl; triacylglycerol; chlorinated hydrocarbon; adipose tissue; adult; Article; body mass; caloric intake; cholesterol blood level; controlled study; cross-sectional study; exercise; fat intake; female; gas chromatography; human; human experiment; male; mass spectrometry; non-smoker; normal human; nutritional status; people by smoking status; persistent organic pollutant; physical activity; triacylglycerol level; middle aged; nutrition; young adult | English | 2020 | 2020-10 | 10.4093/dmj.2019.0158 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Coronavirus Disease 2019 and Diabetes: The Epidemic and the Korean Diabetes Association Perspective | Diabetes has been associated with more severe outcomes and higher mortality in coronavirus disease 2019 (COVID-19) patients compare to morbidity and mortality in patients without diabetes. Several mechanisms may play a role in this greater morbidity and mortality, especially uncontrolled hyperglycemia, an impaired immune system, pre-existing proinflammatory states, multiple comorbidities, and dysregulated angiotensin-converting enzyme 2 signaling. Thus, the diabetes medical community emergently needs to know about COVID-19 and its effects on patients with diabetes, as they must take precautions to carefully manage these patients during the COVID-19 pandemic. The Korean Diabetes Association provides some guidance and practical recommendations for the management of diabetes during the pandemic. This report provides insight into the association between diabetes and COVID-19, proper management of diabetes in patients with COVID-19 and an official suggestion by the Korean Diabetes Association for managing the COVID-19 outbreak. | Noh, Junghyun; Chang, Hyun-Ha; Jeong, In-Kyung; Yoon, Kun Ho | Inje Univ, Div Endocrinol & Metab, Dept Internal Med, Ilsan Paik Hosp, Goyang, South Korea; Kyungpook Natl Univ, Div Infect Dis, Dept Internal Med, Sch Med, Daegu, South Korea; Kyung Hee Univ, Dept Endocrinol & Metab, Kyung Hee Univ Hosp Gangdong, Sch Med, 892 Dongnam Ro, Seoul 05278, South Korea; Catholic Univ Korea, Div Endocrinol & Metab, Dept Internal Med, Coll Med, 222 Banpo Daero, Seoul 06591, South Korea | Kim, Dong Ki/J-5389-2012; Jeong, In-Kyung/AAI-6488-2020; Noh, Junghyun/AAU-8113-2020 | 8868135900; 7407521688; 7101712552; 7401607578 | jik1016@khu.ac.kr;yoonk@catholic.ac.kr; | DIABETES & METABOLISM JOURNAL | DIABETES METAB J | 2233-6079 | 2233-6087 | 44 | 3 | SCIE | ENDOCRINOLOGY & METABOLISM | 2020 | 5.376 | 22.3 | 0.53 | 2025-06-25 | 11 | 13 | COVID-19; Diabetes mellitus; Severe acute respiratory syndrome coronavirus 2 | CLINICAL CHARACTERISTICS; COVID-19; RECEPTOR; OUTCOMES; RISK; MECHANISMS; INFECTION; PNEUMONIA; RELEVANCE; MELLITUS | COVID-19; Diabetes mellitus; Severe acute respiratory syndrome coronavirus 2 | Coronavirus Infections; Diabetes Complications; Disease Management; Humans; Pandemics; Pneumonia, Viral; angiotensin converting enzyme 2; antidiabetic agent; comorbidity; coronavirus disease 2019; diabetes mellitus; disease association; disease severity; human; hyperglycemia; immune system; Korean (people); mortality; renin angiotensin aldosterone system; Review; risk factor; signal transduction; complication; Coronavirus infection; diabetic complication; disease management; pandemic; practice guideline; virology; virus pneumonia | English | 2020 | 2020-06 | 10.4093/dmj.2020.0138 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Efficacy and Safety of Omega-3 Fatty Acids in Patients Treated with Statins for Residual Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial | Background: Cardiovascular risk remains increased despite optimal low density lipoprotein cholesterol (LDL-C) level induced by intensive statin therapy. Therefore, recent guidelines recommend non-high density lipoprotein cholesterol (non-HDL-C) as a secondary target for preventing cardiovascular events. The aim of this study was to assess the efficacy and tolerability of omega-3 fatty acids (OM3-FAs) in combination with atorvastatin compared to atorvastatin alone in patients with mixed dyslipidemia. Methods: This randomized, double-blind, placebo-controlled, parallel-group, and phase III multicenter study included adults with fasting triglyceride (TG) levels >= 200 and <500 mg/dL and LDL-C levels <110 mg/dL. Eligible subjects were randomized to ATOMEGA (0M3-FAs 4,000 mg plus atorvastatin calcium 20 mg) or atorvastatin 20 mg plus placebo groups. The primary efficacy endpoints were the percent changes in TG and non-HDL-C levels from baseline at the end of treatment. Results: After 8 weeks of treatment, the percent changes from baseline in TG (-29.8% vs. 3.6%, P <0.001) and non-HDL-C (-10.1% vs. 4.9%, P<0.001) levels were significantly greater in the ATOMEGA group (n=97) than in the atorvastatin group (n =103). Moreover, the proportion of total subjects reaching TG target of <200 mg/dL in the ATOMEGA group was significantly higher than that in the atorvastatin group (62.9% vs. 22.3%, P< 0.001). The incidence of adverse events did not differ between the two groups. Conclusion: The addition of OM3-FAs to atorvastatin improved TG and non-I IDL-C levels to a significant extent compared to atorvastatin alone in subjects with residual hypertriglyceridemia. | Jun, Ji Eun; Jeong, In Kyung; Yu, Jae Myung; Kim, Sung Rae; Lee, In Kye; Han, Kyung-Ah; Choi, Sung Hee; Kim, Soo-Kyung; Park, Hyeong Kyu; Mok, Ji-Oh; Lee, Yong-ho; Kwon, Hyuk-Sang; Kim, So Hun; Kang, Ho Cheol; Lee, Sang Ah; Lee, Chang Beom; Choi, Kyung Mook; Her, Sung-Ho; Shin, Won Yong; Shin, Mi-Seung; Ahn, Hyo-Suk; Kang, Seung Ho; Cho, Jin-Man; Jo, Sang-Ho; Cha, Tae-Joon; Kim, Seok Yeon; Won, Kyung Heon; Kim, Dong-Bin; Lee, Jae Hyuk; Lee, Moon-Kyu | Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Dept Endocrinol & Metab, Sch Med, Seoul, South Korea; Hallym Univ, Kangnam Sacred Heart Hosp, Dept Internal Med, Div Endocrinol & Metab,Coll Med, Seoul, South Korea; Catholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Div Endocrinol & Metab,Dept Internal Med, Bucheon, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Endocrinol & Metab Internal Med, Daegu, South Korea; Eulji Univ, Nowon Eulji Med Ctr, Dept Internal Med, Div Endocrinol & Metab,Sch Med, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Div Endocrinol & Metab,Coll Med, Seongnam, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Internal Med, Div Endocrinol & Metab,Sch Med, Seongnam, South Korea; Soonchunhyang Univ, Seoul Hosp, Dept Internal Med, Div Endocrinol & Metab,Coll Med, Seoul, South Korea; Soonchunhyang Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab,Bucheon Hosp, Bucheon, South Korea; Yonsei Univ, Severance Hosp, Dept Internal Med, Div Endocrinol & Metab,Coll Med, Seoul, South Korea; Catholic Univ Korea, Yeouido St Marys Hosp, Coll Med, Div Endocrinol & Metab,Dept Internal Med, Seoul, South Korea; Inha Univ, Inha Univ Hosp, Div Endocrinol & Metab, Sch Med,Dept Internal Med, Incheon, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Internal Med, Div Endocrinol & Metab,Med Sch, Hwasun, South Korea; Jeju Natl Univ, Dept Internal Med, Div Endocrinol & Metab, Sch Med, Jeju, South Korea; Hanyang Univ, Coll Med, Dept Endocrinol & Metab, Guri Hosp, Guri, South Korea; Korea Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab,Guro Hosp, Seoul, South Korea; Catholic Univ Korea, Daejeon St Marys Hosp, Coll Med, Div Cardiol,Dept Internal Med, Daejeon, South Korea; Soonchunhyang Univ, Coll Med, Dept Internal Med, Div Cardiol,Cheonan Hosp, Cheonan, South Korea; Gachon Univ, Gil Med Ctr, Dept Internal Med, Div Cardiol,Coll Med, Incheon, South Korea; Catholic Univ Korea, Uijeongbu St Marys Hosp, Coll Med, Div Cardiol,Dept Internal Med, Uijongbu, South Korea; Cheju Halla Gen Hosp, Dept Internal Med, Div Cardiol, Jeju, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Dept Internal Med, Div Cardiol,Sch Med, Seoul, South Korea; Hallym Univ, Coll Med, Dept Internal Med, Div Cardiol,Sacred Heart Hosp, Anyang, South Korea; Kosin Univ, Coll Med, Dept Internal Med, Div Cardiol,Gospel Hosp, Busan, South Korea; Seoul Med Ctr, Dept Internal Med, Div Cardiol, Seoul, South Korea; Catholic Univ Korea, St Pauls Hosp, Coll Med, Div Cardiol,Dept Internal Med, Seoul, South Korea; Myongji Hosp, Dept Internal Med, Div Endocrinol, Goyang, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Endocrinol & Metab,Sch Med, 81 Irwon Ro, Seoul 05351, South Korea | Choi, Sung-hee/J-5689-2012; Kim, Nan/T-8627-2019; Choi, Kyung/C-4195-2018; CHAO, TZE-FAN/JAX-3231-2023; Kim, Seong Cheol/ABD-1493-2022; Jeong, In-Kyung/AAI-6488-2020; Lee, Sang/O-8501-2017; Lee, Yong-ho/AAT-4106-2020; Kim, Hyungduk/CAH-5630-2022; Kang, Ho-Cheol/E-7969-2011; choi, sun ryoung/AGZ-1893-2022; Lee, In-Kyu/AAR-6374-2021; Park, Kyoung Un/J-5473-2012 | 56684152500; 7101712552; 55682098800; 35187268000; 59060573600; 14627184100; 56181488400; 57141278000; 55702042100; 55443823500; 56424219700; 17234172600; 56499561100; 8400902400; 57207065027; 36573723400; 7403949874; 12806475600; 57211514554; 7401536670; 24477046000; 57215426484; 57202595152; 8729641900; 27169574000; 25959172500; 56715123300; 23090741800; 55328571100; 7409120503 | leemk@skku.edu; | DIABETES & METABOLISM JOURNAL | DIABETES METAB J | 2233-6079 | 2233-6087 | 44 | 1 | SCIE | ENDOCRINOLOGY & METABOLISM | 2020 | 5.376 | 22.3 | 0.63 | 2025-06-25 | 7 | 9 | Atorvastatin; Fatty acids; omega-3; Hypertriglyceridemia | CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR-DISEASE; EICOSAPENTAENOIC ACID; TRIGLYCERIDE LEVELS; FATTY-ACIDS; RISK; DYSLIPIDEMIA; ATORVASTATIN; INDIVIDUALS | Atorvastatin; Fatty acids; Hypertriglyceridemia; Omega-3 | Aged; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Fatty Acids, Omega-3; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Linear Models; Male; Middle Aged; Triglycerides; antihypertensive agent; atorvastatin; creatine kinase; high density lipoprotein cholesterol; low density lipoprotein cholesterol; olive oil; omega 3 fatty acid; placebo; triacylglycerol; atorvastatin; high density lipoprotein cholesterol; hydroxymethylglutaryl coenzyme A reductase inhibitor; low density lipoprotein cholesterol; omega 3 fatty acid; triacylglycerol; adult; aged; arm fracture; Article; cholesterol blood level; controlled study; creatine kinase blood level; diabetes mellitus; dietary intake; double blind procedure; drug efficacy; drug safety; drug tolerability; dyslipidemia; fasting; female; human; hyperglycemia; hypertension; hypertriglyceridemia; major clinical study; male; middle aged; multicenter study; outcome assessment; phase 3 clinical trial; randomized controlled trial; risk assessment; side effect; treatment duration; treatment response; triacylglycerol blood level; blood; clinical trial; hypertriglyceridemia; statistical model | English | 2020 | 2020-02 | 10.4093/dmj.2018.0265 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Evaluation of cognitive function in adult rhesus monkeys using the finger maze test | In research on cognitive function, the use of experimental animals is essential for the study of human cognitive processes and mechanisms. Furthermore, non-human primates are necessary for understanding higher cognitive functions in humans. However, there are few cognitive function tests available for non-human primates, Thus, we modified a finger maze test for application to non-human primates. In this study, we assessed learning and memory in 12 adult rhesus monkeys using a finger maze test that was developed to assess cognitive functions in captive non-human primates. The monkeys were trained with moving rewards indicating the correct direction, which allowed the monkeys to obtain the reward. Following training, subjects completed a learning trial and a memory trial two months later. Although the time required for training varied among the monkeys, 11 out of 12 monkeys completed the training and achieved a high success rate in the learning trial as well as in the memory trial conducted 2 months later. This is the first study to apply the finger maze test to adult rhesus monkeys. The finger maze test enabled us to assess learning and memory in several adult rhesus monkeys simultaneously. | Kim, Keonwoo; Jeon, Hyeon-Ae; Seo, Jincheol; Park, Junghyung; Won, Jinyoung; Yeo, Hyeon-Gu; Jeon, Chang-Yeop; Huh, Jae-Won; Kim, Young-Hyun; Hong, Yonggeun; Choi, Ji-Woong; Lee, Youngjeon | Korea Res Inst Biosci & Biotechnol, Natl Primate Res Ctr, 30 Yeongudanji Ro, Cheongju 28116, Chungbuk, South Korea; Inje Univ, Dept Phys Therapy, Grad Sch, Gimhae 50834, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Dept Brain & Cognit Sci, Daegu 42988, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea; Korea Univ Sci & Technol, KRIBB Sch Biosci, Dept Funct Genom, Daejeon 34113, South Korea; DGIST, Dept Informat & Commun Engn, 333 Techno Jungang Daero, Daegu 42988, South Korea; DGIST, Brain Engn Convergence Res Ctr, Daegu 42988, South Korea; DGIST, Max Planck Inst Human Cognit & Brain Sci, Partner Grp, Dept Brain & Cognit Sci, Daegu 42988, South Korea | Jeon, Hyeon-Ae/KIH-5375-2024; 김, 영현/HLH-3847-2023; Lee, Youngjeon/LZH-8969-2025; Park, Junghyung/KXQ-7522-2024 | 57204572034; 16203006700; 57200518242; 55671747100; 56018670200; 56263762800; 56522472100; 16645802900; 54393408600; 35487507000; 23392263200; 57199022088 | jwchoi@dgist.ac.kr;neurosci@kibb.re.kr;neurosci@kribb.re.kr; | APPLIED ANIMAL BEHAVIOUR SCIENCE | APPL ANIM BEHAV SCI | 0168-1591 | 1872-9045 | 224 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE;BEHAVIORAL SCIENCES;VETERINARY SCIENCES | 2020 | 2.448 | 22.3 | 1.1 | 2025-06-25 | 7 | 7 | Rhesus monkey; Cognitive function; Finger maze; Learning test; Memory test | INTRACEREBROVENTRICULAR INJECTION; MEMORY; ANTAGONISTS; MACAQUES; MODEL | Cognitive function; Finger maze; Learning test; Memory test; Rhesus monkey | Animalia; Macaca mulatta; Primates; adult; cognition; experimental study; primate; testing method; training | English | 2020 | 2020-03 | 10.1016/j.applanim.2020.104945 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice | Renal fibrosis is considered to be the final common outcome of chronic kidney disease. Dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated protective effects against diabetic kidney disease. However, the anti-fibrotic effect of evogliptin, a DPP-4 inhibitor, has not been studied. Here, we report the beneficial effects of evogliptin on unilateral ureteral obstruction (UUO)-induced renal fibrosis in mice. Evogliptin attenuated UUO-induced renal atrophy and tubulointerstitial fibrosis. Immunohistochemistry and Western blotting demonstrated that evogliptin treatment inhibits pro-fibrotic gene expressions and extracellular matrix production. In vitro findings showed that the beneficial effects of evogliptin on renal fibrosis are mediated by inhibition of the transforming growth factor-beta/Smad3 signaling pathway. The present study demonstrates that evogliptin is protective against UUO-induced renal fibrosis, suggesting that its clinical applications could extend to the treatment of kidney disease of non-diabetic origin. | Kim, Mi-Jin; Kim, Na-young; Jung, Yun-A; Lee, Seunghyeong; Jung, Gwon-Soo; Kim, Jung-Guk; Lee, In-Kyu; Lee, Sungwoo; Choi, Yeon-Kyung; Park, Keun-Gyu | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu, South Korea | ; Lee, In-Kyu/AAR-6374-2021 | 58364690500; 57201292256; 55662703500; 57204501802; 26665527300; 16506485900; 36071537600; 57189250997; 35335932600; 57202558343 | exc4932@hanmail.net;kpark@knu.ac.kr; | DIABETES & METABOLISM JOURNAL | DIABETES METAB J | 2233-6079 | 2233-6087 | 44 | 1 | SCIE | ENDOCRINOLOGY & METABOLISM | 2020 | 5.376 | 22.3 | 0.87 | 2025-06-25 | 10 | 11 | Dipeptidyl-peptidase IV inhibitors; Kidney failure, chronic; Transforming growth factor beta | IV INHIBITOR; MOUSE MODEL; PROTECTS; DA-1229; INJURY; DPP-4 | Chronic; Dipeptidyl-peptidase IV inhibitors; Kidney failure; Transforming growth factor beta | Animals; Dipeptidyl-Peptidase IV Inhibitors; Fibrosis; Inflammation; Kidney Diseases; Kidney Tubules, Proximal; Mice; Mice, Inbred C57BL; Piperazines; Protective Agents; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Ureteral Obstruction; evogliptin; Smad3 protein; transforming growth factor beta; 4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one; dipeptidyl peptidase IV inhibitor; piperazine derivative; protective agent; Smad3 protein; transforming growth factor beta; animal experiment; animal model; antifibrotic activity; Article; atrophy; controlled study; drug effect; extracellular matrix; gene expression; immunohistochemistry; in vitro study; kidney fibrosis; mouse; nonhuman; renal atrophy; signal transduction; tubulointerstitial fibrosis; unilateral ureteral obstruction; ureter obstruction; Western blotting; animal; C57BL mouse; complication; fibrosis; inflammation; kidney disease; kidney proximal tubule; metabolism; pathology; ureter obstruction | English | 2020 | 2020-02 | 10.4093/dmj.2018.0271 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association | This clinical practice position statement, a product of the Fatty Liver Research Group of the Korean Diabetes Association, proposes recommendations for the diagnosis, progression and/or severity assessment, management, and follow-up of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Patients with both T2DM and NAFLD have an increased risk of non-alcoholic steatohepatitis (NASH) and fibrosis and a higher risk of cardiovascular diseases and diabetic complications compared to those without NAFLD. With regards to the evaluation of patients with T2DM and NAFLD, ultrasonography-based stepwise approaches using noninvasive biomarker models such as fibrosis-4 or the NAFLD fibrosis score as well as imaging studies such as vibration-controlled transient elastography with controlled attenuation parameter or magnetic resonance imaging-proton density fat fraction are recommended. After the diagnosis of NAFLD, the stage of fibrosis needs to be assessed appropriately. For management, weight reduction achieved by lifestyle modification has proven beneficial and is recommended in combination with antidiabetic agent(s). Evidence that some antidiabetic agents improve NAFLD/NASH with fibrosis in patients with T2DM is emerging. However, there are currently no definite pharmacologic treatments for NAFLD in patients with T2DM. For specific cases, bariatric surgery may be an option if indicated. | Lee, Byung-Wan; Lee, Yong-Ho; Park, Cheol-Young; Rhee, Eun-Jung; Lee, Won-Young; Kim, Nan-Hee; Choi, Kyung Mook; Park, Keun-Gyu; Choi, Yeon-Kyung; Cha, Bong-Soo; Lee, Dae Ho | Yonsei Univ, Div Endocrinol & Metab, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Div Endocrinol & Metab, Dept Internal Med,Sch Med, Seoul, South Korea; Korea Univ, Div Endocrinol & Metab, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Div Endocrinol & Metab, Dept Internal Med, Daegu, South Korea; Gachon Univ, Gil Med Ctr, Div Endocrinol & Metab, Dept Internal Med,Coll Med, 21 Namdong Daero 774beon Gil, Incheon 21565, South Korea | Rhee, Eun-Jung/M-9294-2015; Wan, Lee/K-2649-2019; Choi, Kyung/C-4195-2018; Kim, Nan/T-8627-2019; LEE, WON-YOUNG/C-7249-2018 | 15763315600; 56424219700; 7408418273; 7004174408; 57928301300; 57196299667; 7403949874; 57202558343; 35335932600; 7007118478; 56228667700 | bscha@yuhs.ac;drhormone@naver.com; | DIABETES & METABOLISM JOURNAL | DIABETES METAB J | 2233-6079 | 2233-6087 | 44 | 3 | SCIE | ENDOCRINOLOGY & METABOLISM | 2020 | 5.376 | 22.3 | 1.71 | 2025-06-25 | 58 | 55 | Cardiovascular disease; Diabetes mellitus, type 2; Life style; Non-alcoholic fatty liver disease | MAGNETIC-RESONANCE ELASTOGRAPHY; LIFE-STYLE INTERVENTIONS; PLACEBO-CONTROLLED TRIAL; URSODEOXYCHOLIC ACID; HEPATIC STEATOSIS; BARIATRIC SURGERY; WEIGHT-LOSS; VITAMIN-E; HEPATOCELLULAR-CARCINOMA; ADVANCED FIBROSIS | Cardiovascular disease; Diabetes mellitus, type 2; Life style; Non-alcoholic fatty liver disease | Bariatric Surgery; Cardiovascular Diseases; Comorbidity; Diabetes Complications; Diabetes Mellitus, Type 2; Fibrosis; Humans; Hypoglycemic Agents; Life Style; Liver; Non-alcoholic Fatty Liver Disease; Prevalence; Republic of Korea; Risk Factors; Treatment Outcome; 2,4 thiazolidinedione derivative; alpha tocopherol; antidiabetic agent; antilipemic agent; antiobesity agent; carnitine; cenicriviroc; dipeptidyl peptidase IV inhibitor; elafibranor; glucagon like peptide 1 receptor agonist; metformin; obeticholic acid; pentoxifylline; sodium glucose cotransporter 2 inhibitor; ursodeoxycholic acid; algorithm; bariatric surgery; body weight loss; clinical practice; computer assisted tomography; disease exacerbation; echography; fatty liver; follow up; genetic variability; human; lifestyle modification; liver biopsy; liver fibrosis; medical society; non insulin dependent diabetes mellitus; nonalcoholic fatty liver; nonalcoholic steatohepatitis; nuclear magnetic resonance; nuclear magnetic resonance imaging; prevalence; Review; transient elastography; vibration; cardiovascular disease; comorbidity; diabetic complication; fibrosis; lifestyle; liver; non insulin dependent diabetes mellitus; nonalcoholic fatty liver; pathology; risk factor; South Korea; treatment outcome; disease association; elastography; fatty liver; non invasive procedure; nonalcoholic fatty liver; obesity; systematic review; vibration controlled transient elastography | English | 2020 | 2020-06 | 10.4093/dmj.2020.0010 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Letter | Presence of Carotid Plaque Is Associated with Rapid Renal Function Decline in Patients with Type 2 Diabetes Mellitus and Normal Renal Function (Diabetes Metab J 2019;43:840-53) | Kim, Min-Ji; Jeon, Jae-Han | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, 807 Hoguk Ro, Daegu 41404, South Korea | Kim, Min-Ji/Z-5205-2019 | 57206189095; 36910340400 | jeonjh@knu.ac.kr; | DIABETES & METABOLISM JOURNAL | DIABETES METAB J | 2233-6079 | 2233-6087 | 44 | 1 | SCIE | ENDOCRINOLOGY & METABOLISM | 2020 | 5.376 | 22.3 | 0 | 2025-06-25 | 0 | 0 | CHRONIC KIDNEY-DISEASE; PREVALENCE; RISK | C reactive protein; glycosylated hemoglobin; adaptive immunity; age; arterial wall thickness; carotid artery disease; disease association; disease duration; estimated glomerular filtration rate; glycemic control; human; innate immunity; kidney disease; Letter; non insulin dependent diabetes mellitus; risk factor; carotid artery; deterioration; disease course; functional assessment; kidney function; erratum | English | 2020 | 2020-02 | 10.4093/dmj.2020.0017 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The Clinical Characteristics and Outcomes of Patients with Moderate-to-Severe Coronavirus Disease 2019 Infection and Diabetes in Daegu, South Korea | Background: Coronavirus disease 2019 (COVID-19) is a global pandemic that had affected more than eight million people worldwide by June 2020. Given the importance of the presence of diabetes mellitus (DM) for host immunity, we retrospectively evaluated the clinical characteristics and outcomes of moderate-to-severe COVID-19 in patients with diabetes. Methods: We conducted a multi-center observational study of 1,082 adult inpatients (aged >= 18 years) who were admitted to one of five university hospitals in Daegu because of the severity of their COVID-19-related disease. The demographic, laboratory, and radiologic findings, and the mortality, prevalence of severe disease, and duration of quarantine were compared between patients with and without DM. In addition, 1:1 propensity score (PS)-matching was conducted with the DM group. Results: Compared with the non-DM group (n=847), patients with DM (n=235) were older, exhibited higher mortality, and required more intensive care. Even after PS-matching, patients with DM exhibited more severe disease, and DM remained a prognostic factor for higher mortality (hazard ratio, 2.40; 95% confidence interval, 1.38 to 4.15). Subgroup analysis revealed that the presence of DM was associated with higher mortality, especially in older people (>= 70 years old). Prior use of a dipeptidyl peptidase-4 inhibitor or a renin-angiotensin system inhibitor did not affect mortality or the clinical severity of the disease. Conclusion: DM is a significant risk factor for COVID-19 severity and mortality. Our findings imply that COVID-19 patients with DM, especially if elderly, require special attention and prompt intensive care. | Kim, Mi Kyung; Jeon, Jae-Han; Kim, Sung-Woo; Moon, Jun Sung; Cho, Nan Hee; Han, Eugene; You, Ji Hong; Lee, Ji Yeon; Hyun, Miri; Park, Jae Seok; Kwon, Yong Shik; Choi, Yeon-Kyung; Kwon, Ki Tae; Lee, Shin Yup; Jeon, Eon Ju; Kim, Jin-Woo; Hong, Hyo-Lim; Kwon, Hyun Hee; Jung, Chi Young; Lee, Yin Young; Ha, Eunyeoung; Chung, Seung Min; Hur, Jian; Ahn, June Hong; Kim, Na-young; Kim, Shin-Woo; Chang, Hyun Ha; Lee, Yong Hoon; Lee, Jaehee; Park, Keun-Gyu; Kim, Hyun Ah; Lee, Ji-Hyun | Keimyung Univ, Sch Med, Dept Internal Med, Dongsan Hosp, 1035 Dalgubeol Daero, Daegu 42601, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Daegu Catholic Univ, Daegu Catholic Univ Hosp, Dept Internal Med, Sch Med, 33 Duryugongwon Ro 17 Gil, Daegu 42472, South Korea; Yeungnam Univ, Yeungnam Univ Hosp, Dept Internal Med, Coll Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea | Lee, Yoojin/AAB-9799-2022; LEE, WON-YOUNG/C-7249-2018; Chung, Seung Min/HNC-5825-2023; Kim, Sung-Eun/ABC-8837-2020; Lee, Jaehee/S-1697-2018; Ahn, June/AAB-3093-2019; Lee, YoungMi/JCF-0461-2023; Kim, Eun/AAS-6706-2020; Hwang, Soyoon/HHM-5762-2022 | 59124316400; 36910340400; 57206876109; 55261990400; 57213714680; 56942969800; 57218697250; 57216774221; 55927698200; 8866846500; 57203804743; 35335932600; 9733850500; 49863712700; 57206169900; 57218697417; 55440169300; 16301508200; 57223991305; 57217699649; 57216645230; 57192252291; 19934047300; 56645445800; 57201292256; 57189703358; 7407521688; 57199022948; 13805476000; 57202558343; 57059615500; 58374693900 | hyunah1118@dsmc.or.kr;jhlee9@cu.ac.kr; | DIABETES & METABOLISM JOURNAL | DIABETES METAB J | 2233-6079 | 2233-6087 | 44 | 4 | SCIE | ENDOCRINOLOGY & METABOLISM | 2020 | 5.376 | 22.3 | 5.83 | 2025-06-25 | 74 | 82 | COVID-19; Diabetes mellitus; Mortality; Prognosis | COVID-19; HYPERGLYCEMIA; MORTALITY; MELLITUS | COVID-19; Diabetes mellitus; Mortality; Prognosis | Adult; Aged; Aged, 80 and over; Alanine Transaminase; Angiotensin-Converting Enzyme Inhibitors; Aspartate Aminotransferases; Betacoronavirus; C-Reactive Protein; Case-Control Studies; Comorbidity; Coronavirus Infections; Diabetes Mellitus; Dipeptidyl-Peptidase IV Inhibitors; Female; Humans; Length of Stay; Logistic Models; Lymphocytosis; Male; Middle Aged; Multivariate Analysis; Pandemics; Pneumonia, Viral; Prognosis; Propensity Score; Proportional Hazards Models; Quarantine; Republic of Korea; Risk Factors; Severity of Illness Index; Thrombocytopenia; 2,4 thiazolidinedione derivative; alpha glucosidase inhibitor; beta adrenergic receptor blocking agent; calcium channel blocking agent; dipeptidyl peptidase IV inhibitor; diuretic agent; insulin; metformin; sodium glucose cotransporter 2 inhibitor; sulfonylurea; antihypertensive agent; beta adrenergic receptor blocking agent; calcium channel blocking agent; diuretic agent; renin angiotensin system inhibitor; unclassified drug; alanine aminotransferase; aspartate aminotransferase; C reactive protein; dipeptidyl carboxypeptidase inhibitor; adult; aged; Article; artificial ventilation; clinical feature; controlled study; coronavirus disease 2019; coughing; diabetes mellitus; diarrhea; disease severity; dyspnea; female; fever; headache; high flow nasal cannula therapy; human; intensive care; major clinical study; male; middle aged; myalgia; observational study; outcome assessment; pneumonia; prevalence; quarantine; real time polymerase chain reaction; retrospective study; rhinorrhea; Severe acute respiratory syndrome coronavirus 2; sore throat; South Korea; university hospital; coronavirus disease 2019; diabetes mellitus; disease severity; hospital mortality; laboratory test; mortality; treatment outcome; Betacoronavirus; case control study; comorbidity; Coronavirus infection; diabetes mellitus; length of stay; lymphocytosis; metabolism; mortality; multivariate analysis; pandemic; pathophysiology; prognosis; propensity score; proportional hazards model; risk factor; severity of illness index; statistical model; thrombocytopenia; very elderly; virus pneumonia | English | 2020 | 2020-08 | 10.4093/dmj.2020.0146 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The relationship between the perception of open disclosure of patient safety incidents, perception of patient safety culture, and ethical awareness in nurses | Background Scientific advances have resulted in more complex medical systems, which in turn have led to an increase in the number of patient safety incidents (PSIs). In this environment, the importance of honest disclosure of PSIs is rising, which highlight the need to settle a reliable system. This study aimed to investigate the effects of patient safety culture and ethical awareness on open disclosure of PSIs. Methods Data were collected from 389 nurses using self-reported perceptions of open disclosure of PSIs, perceptions of patient safety culture, and ethical awareness. Results Perception of open disclosure of PSIs was significantly correlated with ethical awareness and perception of patient safety culture. Ethical awareness had the greatest impact on perception of PSIs, and two components of the perception of patient safety culture, namely overall knowledge about patient safety and staffing, were found to have significant effects. Conclusions To enhance nurses' perception of open disclosure of PSIs, educational curriculum and programs that teach and practice fundamental ethical values are needed. Furthermore, it also calls for effort on the part of healthcare institutions and the government, as well as people's trust, to implement a legal safety net and foster patient safety culture to promote honest disclosure of PSIs to patients. | Kim, Yujeong; Lee, Eunmi | Kyungpook Natl Univ, Res Inst Nursing Sci, Coll Nursing, 680 Gukchabosangro, Daegu 41944, South Korea; Hoseo Univ, Res Inst Basic Sci, Dept Nursing, 20,Hoseo Ro79Beon Gil, Asan 31499, Chungcheongnam, South Korea | Lee, Eunmi/AAS-2561-2020 | 57200941945; 57202264064 | sweetbear2@hanmail.net; | BMC MEDICAL ETHICS | BMC MED ETHICS | 1472-6939 | 21 | 1 | SSCI;SCIE | ETHICS;MEDICAL ETHICS;SOCIAL SCIENCES, BIOMEDICAL | 2020 | 2.652 | 22.3 | 0.34 | 2025-06-25 | 11 | 12 | Disclosure; Patient safety; Ethical awareness; Principle-based ethics | MEDICAL ERRORS; EXPERIENCES; PHYSICIANS; ATTITUDES | Disclosure; Ethical awareness; Patient safety; Principle-based ethics | Disclosure; Humans; Nurses; Patient Safety; Perception; Safety Management; adult; article; awareness; case report; clinical article; curriculum; drug safety; ethics; female; government; human; male; nurse; patient safety; perception; trust; interpersonal communication; perception; safety | English | 2020 | 2020-10-27 | 10.1186/s12910-020-00546-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Signature mRNA markers in extracellular vesicles for the accurate diagnosis of colorectal cancer | Background With the increasing incidence of colorectal cancer (CRC), its accurate diagnosis is critical and in high demand. However, conventional methods are not ideal due to invasiveness and low accuracy. Herein, we aimed to identify efficient CRC mRNA markers in a non-invasive manner using CRC-derived extracellular vesicles (EVs). The expression levels of EV mRNAs from cancer cell lines were compared with those of a normal cell line using quantitative polymerase chain reaction. Eight markers were evaluated in plasma EVs from CRC patients and healthy controls. The diagnostic value of each marker, individually or in combination, was then determined using recessive operating characteristics analyses and the Mann-Whitney U test. Results Eight mRNA markers (MYC, VEGF, CDX2, CD133, CEA, CK19, EpCAM, and CD24) were found to be more abundant in EVs derived from cancer cell lines compared to control cell lines. A combination of VEGF and CD133 showed the highest sensitivity (100%), specificity (80%), and accuracy (93%) and an area under the curve of 0.96; hence, these markers were deemed to be the CRC signature. Moreover, this signature was found to be highly expressed in CRC-derived EVs compared to healthy controls. Conclusions VEGF and CD133 mRNAs comprise a unique CRC signature in EVs that has the potential to act as a novel, non-invasive, and accurate biomarker that would improve the current diagnostic platform for CRC, while also serving to strengthen the value of EV mRNA as diagnostic markers for myriad of diseases. | Cha, Byung Seok; Park, Ki Soo; Park, Jun Seok | Konkuk Univ, Coll Engn, Dept Biol Engn, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Kyungpook Natl Univ Chilgok Hosp, Colorectal Canc Ctr, Daegu, South Korea | Park, Joonhong/AAZ-9885-2020; Park, Ki/AAR-2461-2021 | 57209531340; 57217129256; 35226761100 | akdong486@konkuk.ac.kr;parkjs0802@knu.ac.kr; | JOURNAL OF BIOLOGICAL ENGINEERING | J BIOL ENG | 1754-1611 | 14 | 1 | SCIE | BIOCHEMICAL RESEARCH METHODS;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2020 | 4.355 | 22.4 | 1.44 | 2025-06-25 | 31 | 30 | Colorectal cancer; Extracellular vesicle; mRNA; VEGF; CD133; Non-invasive biomarker | TIME RT-PCR; PERIPHERAL-BLOOD; SERUM CEA; EXPRESSION; CELLS; BIOMARKER | CD133; Colorectal cancer; Extracellular vesicle; mRNA; Non-invasive biomarker; VEGF | aldehyde dehydrogenase isoenzyme 1; carcinoembryonic antigen; CD133 antigen; CD24 antigen; cytokeratin 19; epidermal growth factor receptor; epithelial cell adhesion molecule; frizzled protein; frizzled10 protein; Hermes antigen; messenger RNA; Myc protein; transcription factor Cdx2; tumor marker; unclassified drug; vasculotropin; adult; aged; area under the curve; Article; cancer staging; clinical article; colorectal cancer; colorectal cancer cell line; controlled study; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; exosome; female; human; human cell; male; middle aged; non invasive measurement; priority journal; protein expression; sensitivity and specificity; tumor differentiation; tumor localization | English | 2020 | 2020-02-04 | 10.1186/s13036-020-0225-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The influence of the compromise and travel temporal construal heuristics on a purchase decision | This study empirically investigated the effects of temporal construal upon the compromise effect; the extent to which the importance of price and quality attributes to selecting a compromised option changed over time; and the malleability of the influence of the temporal construal heuristic by changing the time parameters. Three hundred and ninety-four questionnaires were used for further data analysis. The study's results suggested that the compromise effect was present in the tourism context, but with weakened effectiveness when the time frame in which the purchase can be used was moved back. The importance of price and quality was different between those groups who selected each of three options. The importance of price level in selecting a middle option was not different in terms of temporal construal, but the quality level was a more important consideration in selecting a middle option for future use than for use today. | Jeong, Ji Youn; Crompton, John L.; Hyun, Sunghyup Sean | Kyungpook Natl Univ, Div Environm & Ecotourism, 2559 Gyeongsang Daero, Sangju 37224, South Korea; Texas A&M Univ, Dept Recreat Pk & Tourism Sci, 600 John Kimbrough Blvd,Suite 445, College Stn, TX 77843 USA; Hanyang Univ, Sch Tourism, 17 Haengdang Dong, Seoul 133791, South Korea | ; Jeong, Ji Youn/KBB-3881-2024; Hyun, Sunghyup/LFT-3310-2024 | 57190002456; 57204337546; 26325461500 | jjeong@knu.ac.kr;jcrompton@tamu.edu;sshyun@hanyang.ac.kr; | TOURISM MANAGEMENT PERSPECTIVES | TOUR MANAG PERSPECT | 2211-9736 | 2211-9744 | 33 | SSCI | HOSPITALITY, LEISURE, SPORT & TOURISM;MANAGEMENT | 2020 | 6.586 | 22.4 | 0.37 | 2025-06-25 | 12 | 11 | Compromise effect; Temporal construal level; Price level; Revenue management; Price-quality heuristics | PSYCHOLOGICAL DISTANCE; LEVEL THEORY; PRICE; TOURISM; CONTEXT; CHOICE; ALTERNATIVES; PERFORMANCE; FOREST; TREES | Compromise effect; Price level; Price-quality heuristics; Revenue management; Temporal construal level | English | 2020 | 2020-01 | 10.1016/j.tmp.2019.100583 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | An Injectable Hyaluronan-Methylcellulose (HAMC) Hydrogel Combined with Wharton's Jelly-Derived Mesenchymal Stromal Cells (WJ-MSCs) Promotes Degenerative Disc Repair | Intervertebral disc (IVD) degeneration is one of the predominant causes of chronic low back pain (LBP), which is a leading cause of disability worldwide. Despite substantial progress in cell therapy for the treatment of IVD degeneration, significant challenges remain for clinical application. Here, we investigated the effectiveness of hyaluronan-methylcellulose (HAMC) hydrogels loaded with Wharton's Jelly-derived mesenchymal stromal cell (WJ-MSCs) in vitro and in a rat coccygeal IVD degeneration model. Following induction of injury-induced IVD degeneration, female Sprague-Dawley rats were randomized into four groups to undergo a single intradiscal injection of the following: (1) phosphate buffered saline (PBS) vehicle, (2) HAMC, (3) WJ-MSCs (2 x 10(4) cells), and (4) WJ-MSCs-loaded HAMC (WJ-MSCs/HAMC) (n = 10/each group). Coccygeal discs were removed following sacrifice 6 weeks after implantation for radiologic and histologic analysis. We confirmed previous findings that encapsulation in HAMC increases the viability of WJ-MSCs for disc repair. The HAMC gel maintained significant cell viability in vitro. In addition, combined implantation of WJ-MSCs and HAMC significantly promoted degenerative disc repair compared to WJ-MSCs alone, presumably by improving nucleus pulposus cells viability and decreasing extracellular matrix degradation. Our results suggest that WJ-MSCs-loaded HAMC promotes IVD repair more effectively than cell injection alone and supports the potential clinical use of HAMC for cell delivery to arrest IVD degeneration or to promote IVD regeneration. | Choi, Un Yong; Joshi, Hari Prasad; Payne, Samantha; Kim, Kyoung Tae; Kyung, Jae Won; Choi, Hyemin; Cooke, Michael J.; Kwon, Su Yeon; Roh, Eun Ji; Sohn, Seil; Shoichet, Molly S.; Han, Inbo | CHA Univ, CHA Bundang Med Ctr, Dept Neurosurg, Sch Med, Seongnam Si 13496, South Korea; Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Neurosurg, Daegu 41404, South Korea; Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada; Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada | 57209540640; 57201974279; 56963378100; 57201369790; 56895826800; 57193951350; 57206408986; 57219127846; 57219129044; 55047974500; 7005488600; 9338449900 | nschoiuy@gmail.com;hariprasadjoshi10@gmail.com;Samantha.payne@tufts.edu;nskimkt7@gmail.com;kyungjaewon88@gmail.com;littlechoi88@gmail.com;mikejcooke@amacathera.ca;syunkwon@naver.com;morolro@naver.com;sisohn@cha.ac.kr;molly.shoichet@utoronto.ca;hanib@cha.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 19 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 1.74 | 2025-06-25 | 38 | 36 | mesenchymal stromal cell; Wharton jelly; hyaluronic acid; methylcellulose; intervertebral disc degeneration; regeneration; extracellular matrix | CORD BIOLOGICAL-PROPERTIES; HUMAN UMBILICAL-CORD; INTERVERTEBRAL DISC; STEM-CELLS; SPINAL-CORD; DELIVERY; TRANSPLANTATION; MATURATION; SURVIVAL; THERAPY | Extracellular matrix; Hyaluronic acid; Intervertebral disc degeneration; Mesenchymal stromal cell; Methylcellulose; Regeneration; Wharton jelly | Animals; Biomarkers; Cell Culture Techniques; Cell Survival; Disease Models, Animal; Extracellular Matrix; Gene Expression Regulation, Enzymologic; Hyaluronic Acid; Hydrogels; Immunohistochemistry; Intervertebral Disc Degeneration; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Methylcellulose; Rats; Wharton Jelly; aggrecanase 1; collagenase 3; cyclooxygenase 2; glyceraldehyde 3 phosphate dehydrogenase; hyaluronic acid; hydrogel; inducible nitric oxide synthase; matrix protein; messenger RNA; methylcellulose; phosphate buffered saline; proteoglycan; biological marker; analysis of variance; animal cell; animal experiment; animal model; Article; cell encapsulation; cell viability; coccygeal vertebra; controlled study; down regulation; extracellular matrix; female; gene expression; histology; in vitro study; intervertebral disk degeneration; mesenchymal stroma cell; nonhuman; nucleus pulposus; post hoc analysis; quality control; rat; water content; Wharton jelly; administration and dosage; animal; cell culture technique; cell survival; chemistry; cytology; disease model; gene expression regulation; hydrogel; immunohistochemistry; intervertebral disk degeneration; mesenchymal stem cell; mesenchymal stem cell transplantation; pathology; Wharton jelly | English | 2020 | 2020-10 | 10.3390/ijms21197391 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Biapenem as a Novel Insight into Drug Repositioning against Particulate Matter-Induced Lung Injury | The screening of biologically active chemical compound libraries can be an efficient way to reposition Food and Drug Adminstration (FDA)-approved drugs or to discover new therapies for human diseases. Particulate matter with an aerodynamic diameter equal to or less than 2.5 mu m (PM2.5) is a form of air pollutant that causes significant lung damage when inhaled. This study illustrates drug repositioning with biapenem (BIPM) for the modulation of PM-induced lung injury. Biapenem was used for the treatment of severe infections. Mice were treated with BIPM via tail-vein injection after the intratracheal instillation of PM2.5. Alterations in the lung wet/dry weight, total protein/total cell count and lymphocyte count, inflammatory cytokines in the bronchoalveolar lavage fluid (BALF), vascular permeability, and histology were monitored in the PM2.5-treated mice. BIPM effectively reduced the pathological lung injury, lung wet/dry weight ratio, and hyperpermeability caused by PM2.5. Enhanced myeloperoxidase (MPO) activity by PM2.5 in the pulmonary tissue was inhibited by BIPM. Moreover, increased levels of inflammatory cytokines and total protein by PM2.5 in the BALF were also decreased by BIPM treatment. In addition, BIPM markedly suppressed PM2.5-induced increases in the number of lymphocytes in the BALF. Additionally, the activity of mammalian target of rapamycin (mTOR) was increased by BIPM. Administration of PM2.5 increased the expression levels of toll-like receptor 4 (TLR4), MyD88, and the autophagy-related proteins LC3 II and Beclin 1, which were suppressed by BIPM. In conclusion, these findings indicate that BIPM has a critical anti-inflammatory effect due to its ability to regulate both the TLR4-MyD88 and mTOR-autophagy pathways, and may thus be a potential therapeutic agent against diesel PM2.5-induced pulmonary injury. | Lee, Wonhwa; Baek, Moon-Chang; Kim, Kyung-Min; Bae, Jong-Sup | Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Plus KNU Multi Based Creat Drug Res Team BK21,CMR, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, CMRI, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl BioSci, Div Plant Biosci, Daegu 41566, South Korea | Kim, Kyung-Min Kim/C-7007-2014; Bae, Jong-Sup/AAU-9724-2020; Lee, Wonhwa/GLQ-6506-2022 | 50161632800; 7006013097; 34868260300; 16021543200 | bywonhwalee@gmail.com;mcbaek@knu.ac.kr;kkm@knu.ac.kr;baejs@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 0.36 | 2025-06-25 | 7 | 9 | drug repositioning; biapenem; particulate matter; lung injury; TLR4-mTOR-autophagy | AUTOPHAGY; INFLAMMATION; MTOR; ACTIVATION; PATHWAYS; DISEASE; HEALTH | Biapenem; Drug repositioning; Lung injury; Particulate matter; TLR4-mTOR-autophagy | Animals; Beclin-1; Bronchoalveolar Lavage; Cytokines; Drug Repositioning; Lung; Lung Injury; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Myeloid Differentiation Factor 88; Particulate Matter; Thienamycins; Toll-Like Receptor 4; TOR Serine-Threonine Kinases; autophagy related protein; beclin 1; biapenem; cytokine; dexamethasone; LC3 II protein; mammalian target of rapamycin; myeloid differentiation factor 88; myeloperoxidase; toll like receptor 4; unclassified drug; beclin 1; Becn1 protein, mouse; biapenem; cytokine; MAP1LC3 protein, mouse; microtubule associated protein; mTOR protein, mouse; Myd88 protein, mouse; myeloid differentiation factor 88; target of rapamycin kinase; thienamycin derivative; Tlr4 protein, mouse; toll like receptor 4; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; blood vessel permeability; bronchoalveolar lavage fluid; cell count; concentration (parameter); controlled study; dose response; drug dose comparison; drug efficacy; drug repositioning; dry weight; enzyme activity; enzyme inhibition; histopathology; hyperpermeability; lung injury; lung parenchyma; lung weight; lymphocyte count; male; membrane permeability; mouse; nonhuman; particle size; particulate matter; protein expression; weight; wet weight; animal; Bagg albino mouse; immunology; lung; lung lavage; lymphocyte; particulate matter; pathology; toxicity | English | 2020 | 2020-02 | 10.3390/ijms21041462 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Calcium Channels as Novel Therapeutic Targets for Ovarian Cancer Stem Cells | Drug resistance in epithelial ovarian cancer (EOC) is reportedly attributed to the existence of cancer stem cells (CSC), because in most cancers, CSCs still remain after chemotherapy. To overcome this limitation, novel therapeutic strategies are required to prevent cancer recurrence and chemotherapy-resistant cancers by targeting cancer stem cells (CSCs). We screened an FDA-approved compound library and found four voltage-gated calcium channel blockers (manidipine, lacidipine, benidipine, and lomerizine) that target ovarian CSCs. Four calcium channel blockers (CCBs) decreased sphere formation, viability, and proliferation, and induced apoptosis in ovarian CSCs. CCBs destroyed stemness and inhibited the AKT and ERK signaling pathway in ovarian CSCs. Among calcium channel subunit genes, three L- and T-type calcium channel genes were overexpressed in ovarian CSCs, and downregulation of calcium channel genes reduced the stem-cell-like properties of ovarian CSCs. Expressions of these three genes are negatively correlated with the survival rate of patient groups. In combination therapy with cisplatin, synergistic effect was shown in inhibiting the viability and proliferation of ovarian CSCs. Moreover, combinatorial usage of manidipine and paclitaxel showed enhanced effect in ovarian CSCs xenograft mouse models. Our results suggested that four CCBs may be potential therapeutic drugs for preventing ovarian cancer recurrence. | Lee, Heejin; Kim, Jun Woo; Kim, Dae Kyung; Choi, Dong Kyu; Lee, Seul; Yu, Ji Hoon; Kwon, Oh-Bin; Lee, Jungsul; Lee, Dong-Seok; Kim, Jae Ho; Min, Sang-Hyun | DGMIF, New Drug Dev Ctr, 80 Chumbok Ro, Daegu 41061, South Korea; Kyungpook Natl Univ, Sch Life Sci & Biotechnol, BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea; Pusan Natl Univ, Sch Med, Dept Physiol, Yangsan 50612, South Korea; 3 Bill Inc, Seoul 06621, South Korea | ; Choi, dongKyu/LKL-2959-2024; Kim, Jae/C-5549-2012 | 57202875112; 57215818625; 57102177400; 57215816624; 59057730100; 14526268100; 55197926100; 56050008300; 57210068061; 35268883000; 7202852238 | free7e77@knu.ac.kr;jwkim@dgmif.re.kr;kyumkiki@gmail.com;dongkyu@dgmif.re.kr;autrition15@dgmif.re.kr;yujihoon@dgmif.re.kr;kob325@dgmif.re.kr;jungsullee@gmail.com;leel@knu.ac.kr;jhkimst@pusan.ac.kr;shmin03@dgmif.re.kr;lee1@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1422-0067 | 21 | 7 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 5.924 | 22.5 | 2.32 | 2025-06-25 | 56 | 52 | cancer stem cells; cancer microenvironment; stemness; targeted treatment; calcium channel blocker; drug repositioning | SELF-RENEWAL CAPACITY; NEOPLASTIC TRANSFORMATION; CRUCIAL ROLE; DRUG; IDENTIFICATION; BLOCKERS; PATHWAY; ACTIVATION; APOPTOSIS | Calcium channel blocker; Cancer microenvironment; Cancer stem cells; Drug repositioning; Stemness; Targeted treatment | Animals; Antihypertensive Agents; Apoptosis; Calcium Channel Blockers; Calcium Channels; Carcinoma, Ovarian Epithelial; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Dihydropyridines; Drug Repositioning; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Neoplastic Stem Cells; Ovarian Neoplasms; Paclitaxel; Piperazines; Signal Transduction; Tumor Microenvironment; aldehyde dehydrogenase isoenzyme 1; benidipine; breast cancer resistance protein; calcium channel; calcium voltage gated channel subunit alpha1 g; calcium voltage gated channel subunit alpha1 h; calcium voltage gated channel subunit alpha1 i; caspase 3; caspase 7; CD133 antigen; cisplatin; kruppel like factor 4; lacidipine; lomerizine; manidipine; mitogen activated protein kinase 14; mitogen activated protein kinase 3; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1; octamer transcription factor 4; organic cation transporter 3; paclitaxel; protein bcl 2; protein kinase B; protein mcl 1; small interfering RNA; survivin; transcription factor NANOG; transcription factor Sox2; unclassified drug; voltage gated calcium channel; antihypertensive agent; calcium channel; calcium channel blocking agent; cisplatin; dihydropyridine derivative; paclitaxel; piperazine derivative; animal experiment; animal model; animal tissue; antiapoptotic activity; Article; cancer recurrence; cancer stem cell; cell attached patch clamp; cell migration; cell proliferation assay; cell viability assay; comparative study; controlled study; cytotoxicity; cytotoxicity assay; down regulation; drug sensitivity; gene overexpression; immunohistochemistry; mouse; mRNA expression level; nonhuman; ovary cancer; overall survival; protein expression level; screening test; signal transduction; animal; apoptosis; Bagg albino mouse; cancer stem cell; cell cycle; cell proliferation; cell survival; drug effect; drug repositioning; female; gene expression regulation; genetics; human; metabolism; ovary tumor; tumor cell line; tumor microenvironment | English | 2020 | 2020-04 | 10.3390/ijms21072327 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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