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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Alginate Nonwoven-Sponge Composite Scaffold for Rotator Cuff Tendon Repair | Growth factor-mediated healing of rotator cuff tendon requires to develop a clinically applicable biomaterial playing roles of mechanical support and growth factor releasein vivo.In this study, the alginate (AG) nonwoven-sponge composite scaffold (AGNWSP) was fabricated through the formation of an AG sponge layer on the AG nonwoven scaffold (AGNW) surface, and rotator cuff repair with the AG-based scaffolds containing transforming growth factor-beta 1 (TGF-beta 1) was investigated with a rabbit model. AGNWSP had higher tensile strength, lower bioabsorbability, and higher sustained TGF-beta 1 release capacity than AGNW, which were highly correlated with tendon regeneration. AGNW and AGNWSP were fixed to the ruptured tendon-to-bone sites, and fresh solutions of TGF-beta 1 were injected into the scaffolds. When AGNWSP was applied, the repaired supraspinatus tendon had higher ultimate failure load and stress. In addition, well-organized collagen fibers and fibrocartilages were observed at the tendon-to-bone interface in this case. It is suggested that high degree of ruptured rotator cuff healing could be achieved with AGNWSP in combination with TGF-beta 1. | Park, Ga Young; Yoon, Jong Pil; Choi, Jin Hyun | Kyungpook Natl Univ, Dept Biofibers & Biomat Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Orthopaed Surg, Daegu 41944, South Korea; Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu 41940, South Korea | 57190136627; 36098548400; 36076723600 | jinhchoi@knu.ac.kr; | FIBERS AND POLYMERS | FIBER POLYM | 1229-9197 | 1875-0052 | 21 | 9 | SCIE | MATERIALS SCIENCE, TEXTILES;POLYMER SCIENCE | 2020 | 2.153 | 22.0 | 0.2 | 2025-06-25 | 5 | 8 | Rotator cuff tendon; Alginate; Nonwoven; Composite scaffold; Transforming growth factor-beta 1 | FLEXOR TENDON; BIOLOGICAL AUGMENTATION; NEUTRALIZING ANTIBODY; GROWTH-FACTORS; FELT GRAFT; IN-VITRO; EXPRESSION; COLLAGEN; ELECTROSPUN; INTEGRITY | Alginate; Composite scaffold; Nonwoven; Rotator cuff tendon; Transforming growth factor-beta 1 | Capacity; Growth; Maintenance; Nonwovens; Release; Scaffolds; Tensile Strength; Nonwoven fabrics; Repair; Tensile strength; Composite scaffolds; Growth factor release; Non-woven scaffolds; Rotator cuff repairs; Supraspinatus tendons; Tendon regeneration; Transforming growth factor beta; Ultimate failure loads; Tendons | English | 2020 | 2020-09 | 10.1007/s12221-020-9771-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | Favorable Long-term Outcomes with Autologous Stem Cell Transplantation for High Risk Patients with Multiple Myeloma Who are Positive at FDG-PET/CT | Cho, Hee Jeong; Baek, Dong Won; Kim, Ju Hyung; Jung, Sung Hoon; Sohn, Sang Kyun; Moon, Joon Ho | Kyungpook Natl Univ Hosp, Daegu, South Korea; Chonnam Natl Univ, Hwasun Hosp, Hwasun, South Korea | BONE MARROW TRANSPLANTATION | BONE MARROW TRANSPL | 0268-3369 | 1476-5365 | 55 | SUPPL 1 | SCIE | HEMATOLOGY;IMMUNOLOGY;ONCOLOGY;TRANSPLANTATION | 2020 | 5.483 | 22.0 | 0 | English | 2020 | 2020-12 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Neuroprotective and Anti-Neuroinflammatory Effects of a Poisonous Plant Croton tiglium Linn. Extract | Neuroinflammation is involved in various neurological diseases. Activated microglia secrete many pro-inflammatory factors and induce neuronal cell death. Thus, the inhibition of excessive proinflammatory activity of microglia leads to a therapeutic effect that alleviates the progression of neuronal degeneration. In this study, we investigated the effect of Croton tiglium (C. tiglium) Linn. extract (CTE) on the production of pro- and anti-inflammatory mediators in microglia and astrocytes via RT-PCR, Western blot, and nitric oxide assay. Neurotoxicity was measured by cell viability assay and GFP image analysis. Phagocytosis of microglia was measured using fluorescent zymosan particles. CTE significantly inhibited the production of neurotoxic inflammatory factors, including nitric oxide and tumor necrosis factor-alpha. In addition, CTE increased the production of the neurotrophic factor, brain-derived neurotrophic factor, and the M2 phenotype of microglia. The culture medium retained after CTE treatment increased the survival of neurons, thereby indicating the neuroprotective effect of CTE. Our findings indicated that CTE inhibited pro-inflammatory response and increased the neuroprotective ability of microglia. In conclusion, although CTE is known to be a poisonous plant and listed on the FDA poisonous plant database, it can be used as a medicine if the amount is properly controlled. Our results suggested the potential benefits of CTE as a therapeutic agent for different neurodegenerative disorders involving neuroinflammation. | Gupta, Deepak Prasad; Park, Sung Hee; Yang, Hyun-Jeong; Suk, Kyoungho; Song, Gyun Jee | Catholic Kwandong Univ, Dept Med Sci, Coll Med, Kangnung 25601, Gangwon Do, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Sch Med, Dept Pharmacol,Plus KNU Biomed Convergence Progra, Daegu 41944, South Korea; Univ Brain Educ, Dept Integrat Biosci, Cheonan 31228, South Korea; Catholic Kwandong Univ, Int St Marys Hosp, Translat Brain Res Ctr, Incheon 22711, South Korea | 57209821796; 57209835195; 24765547700; 7005114595; 7402253055 | gyunjee.song@gmail.com; | TOXINS | TOXINS | 2072-6651 | 12 | 4 | SCIE | FOOD SCIENCE & TECHNOLOGY;TOXICOLOGY | 2020 | 4.546 | 22.0 | 0.66 | 2025-06-25 | 15 | 14 | poisonous plant; neuroinflammation; Croton tiglium Linn; neuroprotection; M2 phenotype; microglia | HIPPOCAMPAL NEUROGENESIS; MICROGLIA; INFLAMMATION; MECHANISMS; PROTEIN; CELLS | Croton tiglium Linn.; M2 phenotype; Microglia; Neuroinflammation; Neuroprotection; Poisonous plant | Animals; Anti-Inflammatory Agents; Astrocytes; Cell Line; Cell Survival; Croton; Lipopolysaccharides; Mice; Microglia; Neurons; Neuroprotective Agents; Nitric Oxide; Phagocytosis; Plant Extracts; Plants, Toxic; Rats; Tumor Necrosis Factor-alpha; Croton Tiglium extract; heme oxygenase 1; lipopolysaccharide; messenger RNA; neurotrophic factor; nitric oxide; tumor necrosis factor; unclassified drug; antiinflammatory agent; lipopolysaccharide; neuroprotective agent; nitric oxide; plant extract; tumor necrosis factor; animal cell; antiinflammatory activity; apoptosis; Article; astrocyte; cell death; cell proliferation; cell viability assay; Croton; Croton tiglium; cytotoxicity; cytotoxicity assay; flow cytometry; fluorescence microscopy; gene expression; image analysis; microglia; MTT assay; nerve cell; nervous system inflammation; neuroprotection; neurotoxicity; nonhuman; phagocytosis; phenotype; poisonous plant; protein expression; tumor necrosis; upregulation; Western blotting; animal; cell line; cell survival; drug effect; metabolism; mouse; rat | English | 2020 | 2020-04 | 10.3390/toxins12040261 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Synthesis of an Acid-gas Sensing Fluorescence Dye Showing Change of Both Color and Fluorescence Emission Spectrum inside Polyethylenic Fiber on Exposure to Gas Phase Strong Acid for Application to Washable Textile Sensors | A halochromic fluorescence dye was synthesized to fabricate acid-gas sensing textiles. The dye has a maximum absorption at 436 nm and stokes shift of 54 nm in ethanol, which means that it exhibits a typical fluorescence color of greenish yellow. The dye was designed to have good substantivity toward hydrophobic and chemical resistant polyethylenic fibers, such as high molecular weight polyethylene (HMWPE) fibers, by introducing di-butyl and t-butyl groups on coumarin and benzoxazole moieties of the chromophore, respectively. The fluorescence dye showed the change of both color and fluorescence emission properties not only in a solution by addition of hydrochloric acid but also inside the HMWPE fiber on exposure to gas phase hydrogen chloride even at relatively low concentrations. From the repeat test, the sensing performance was maintained reversibly even after 20 repeat cycles of adsorption and desorption of gas phase hydrogen chloride. The HMWPE fabrics dyed with the fluorescence dye can be washable by showing fastness of rating 4-5 to washing. | Lee, Junheon; Kim, Taekyeong | Kyungpook Natl Univ, Coll Engn, Dept Text Syst Engn, Daegu 41566, South Korea | 57195904688; 24587275700 | taekyeong@knu.ac.kr; | FIBERS AND POLYMERS | FIBER POLYM | 1229-9197 | 1875-0052 | 21 | 10 | SCIE | MATERIALS SCIENCE, TEXTILES;POLYMER SCIENCE | 2020 | 2.153 | 22.0 | 0.26 | 2025-06-25 | 7 | 7 | Acid gas; Chemosensor; Halochromic; Fluorescence; Polyethylene | CHEMOSENSORS; YELLOW | Acid gas; Chemosensor; Fluorescence; Halochromic; Polyethylene | Chlorine Compounds; Chromophores; Color Fastness; Dyes; Emission Spectroscopy; Chemical detection; Chlorine compounds; Chromophores; Color; Color fastness; Dyes; Emission spectroscopy; Fibers; Fluorescence; Gas detectors; Hydrochloric acid; Polyethylenes; Smart textiles; Adsorption and desorptions; Chemical resistant; Fluorescence emission; Fluorescence emission spectra; High molecular weight polyethylenes; Hydrogen chloride; Low concentrations; Sensing performance; Gases | English | 2020 | 2020-10 | 10.1007/s12221-020-1094-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Synthesis of Super Hydrophobic Disperse Dyes Having Long Alkyl Substituents and Their Dyeability onto Unmodified Polypropylene Fibers | The new series of super hydrophobic disperse dyes having different length of alkyl substituents was synthesized to dye pure polypropylene fibers. From butyl to dodecyl groups were introduced to an anthraquinoid chromophore. The adsorption interaction of the dyes toward the polypropylene fiber was increased with the increase of the length of alkyl chains due to enhancement of hydrophobicity of the dyes. The optimum alkyl group was determined as the longest dodecyl group in this study. Their absorption spectra in the visible range appeared almost the same regardless of the length of alkyl groups, which meant that the length of alkyl groups did not influence on optical properties of the dyes relating to color appearances. The color fastnesses of the dyed fabrics to washing, rubbing, and light were good enough for practical application. | Ma, Heejung; Kim, Taekyeong | Kyungpook Natl Univ, Coll Engn, Dept Text Syst Engn, Daegu 41566, South Korea | 57195906371; 24587275700 | taekyeong@knu.ac.kr; | FIBERS AND POLYMERS | FIBER POLYM | 1229-9197 | 1875-0052 | 21 | 8 | SCIE | MATERIALS SCIENCE, TEXTILES;POLYMER SCIENCE | 2020 | 2.153 | 22.0 | 0.13 | 2025-06-25 | 2 | 2 | Polypropylene; Dyeing; Hydrophobicity; Anthraquinoid dye; Disperse dye | YELLOW DYES; COLORATION | Anthraquinoid dye; Disperse dye; Dyeing; Hydrophobicity; Polypropylene | Alkyl Groups; Chromophores; Disperse Dyes; Optical Properties; Water Repellence; Chromophores; Dyes; Hydrophobicity; Optical properties; Adsorption interactions; Alkyl groups; Alkyl substituent; Color appearance; Disperse dyes; Dodecyl groups; Polypropylene fiber; Visible range; Polypropylenes | English | 2020 | 2020-08 | 10.1007/s12221-020-9238-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Current status and future potential of predictive biomarkers for immune checkpoint inhibitors in gastric cancer | Immunotherapy is revolutionising cancer treatment and has already emerged as standard treatment for patients with recurrent or metastatic gastric cancer (GC). Recent research has been focused on identifying robust predictive biomarkers for GC treated with immune checkpoint inhibitors (ICIs). The expression of programmed cell death protein-ligand-1 (PD-L1) is considered a manifestation of immune response evasion, and several studies have already reported the potential of PD-L1 expression as a predictive parameter for various human malignancies. Meanwhile, based on comprehensive molecular characterisation of GC, testing for Epstein-Barr virus and microsatellite instability is a potential predictive biomarker. Culminating evidence suggests that novel biomarkers, such as the tumour mutational burden and gene expression signature, could indicate the success of treatment with ICIs. However, the exact roles of these biomarkers in GC treated with ICIs remain unclear. Therefore, this study reviews recent scientific data on current and emerging biomarkers for ICIs in GC, which have potential to improve treatment outcomes. | Kang, Byung Woog; Chau, Ian | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea; Royal Marsden Hosp, Dept Med, London, England; Royal Marsden Hosp, Dept Med, Surrey, England | Chau, Ian/ABC-2023-2020 | 28567838500; 14526721100 | ian.chau@rmh.nhs.uk; | ESMO OPEN | ESMO OPEN | 2059-7029 | 5 | 4 | SCIE | ONCOLOGY | 2020 | 6.54 | 22.1 | 0.61 | 2025-06-25 | 35 | 28 | immunotherapy; gastric cancer | TUMOR MUTATIONAL BURDEN; TO-LYMPHOCYTE RATIO; CELL LUNG-CANCER; MISMATCH REPAIR DEFICIENCY; INFILTRATING LYMPHOCYTES; MICROSATELLITE INSTABILITY; PD-L1 BLOCKADE; IMMUNOTHERAPY; NEUTROPHIL; MICROBIOME | gastric cancer; immunotherapy | B7-H1 Antigen; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Immune Checkpoint Inhibitors; Stomach Neoplasms; biological marker; ipilimumab; programmed death 1 ligand 1; cancer immunotherapy; gene expression; human; immune response; intestine flora; microsatellite instability; mouse model; neutrophil lymphocyte ratio; nonhuman; protein expression; Review; stomach cancer; treatment outcome; tumor associated leukocyte; Epstein Barr virus; Epstein Barr virus infection; stomach tumor | English | 2020 | 2020-08 | 10.1136/esmoopen-2020-000791 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effects of antipsychotics on rumination in patients with first -episode psychosis | Background Rumination is a well-known risk factor for depression. It is also associated with negative and positive symptoms and suicidality in patients suffering from psychosis. However, no studies have addressed the effect of antipsychotics on rumination. Methods Using the Brooding Scale (BS), we investigated the effect of antipsychotics on rumination at the 6-month follow up in patients with first-episode psychosis (n = 257). The relationship between rumination and other clinical variables was explored by conducting a correlation analysis and structural equation modeling (SEM). The clinical characteristics and short-term outcomes were compared between high and low ruminators at 6 months. Results Significant reductions in rumination and various clinical variables were observed at the 6-month follow-up. A significant correlation was observed between rumination and the score on the positive subscale of the Positive and Negative Syndrome Scale (PANSS). A direct path between the PANSS score and rumination was identified by SEM. High ruminators had more severe psychopathology, experienced more childhood traumas, and took less exercise than low ruminators. The recovery rate at 6 months was higher in low ruminators than in high ruminators. Conclusions Our findings suggest that antipsychotics are beneficial for reducing rumination in patients with first-episode psychosis. The outcomes at the 6-month follow-up were better in low ruminators than high ruminators. | Lee, Youngmin; Kang, Nam-In; Lee, Keon-Hak; Piao, YanHong; Cui, Yin; Kim, Sung-Wan; Lee, Bong Ju; Kim, Jung Jin; Yu, Je-Chun; Lee, Kyu Young; Won, Seung-Hee; Lee, Seung-Hwan; Kim, Seung-Hyun; Kang, Shi Hyun; Kim, Euitae; Kim, Saebom; Chung, Young-Chul | Jeonbuk Natl Univ, Dept Psychiat, Med Sch, Jeonju, South Korea; Maeumsarang Hosp, Dept Psychiat, Wonju, Jeollabuk Do, South Korea; Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai 200030, Peoples R China; Chonnam Natl Univ, Dept Psychiat, Med Sch, Gwangju, South Korea; Inje Univ, Coll Med, Dept Psychiat, Haeundae Paik Hosp, Busan, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Psychiat, Seoul, South Korea; Eulji Univ, Eulji Univ Hosp, Dept Psychiat, Sch Med, Daejeon, South Korea; Eulji Univ, Eulji Gen Hosp, Dept Psychiat, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Psychiat, Sch Med, Daegu, South Korea; Inje Univ, Dept Psychiat, Coll Med, Goyang, South Korea; Korea Univ, Guro Hosp, Dept Psychiat, Coll Med, Seoul, South Korea; Natl Ctr Mental Hlth, Dept Social Psychiat & Rehabil, Seoul, South Korea; Seoul Natl Univ, Dept Psychiat, Bundang Hosp, Seongnam, South Korea; Jeonbuk Natl Univ, Dept Social Welf, Jeonju, South Korea; Jeonbuk Natl Univ, Biomed Res Inst, Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Jeonju 561756, South Korea | Chung, Young/AAB-8242-2022; Lee, Jungmin/KHT-2438-2024; Kim, Jungjin/MTF-3196-2025; Lee, Yo Han/IUN-3410-2023 | 57216951289; 56767602100; 35748813000; 57205143111; 56489073300; 47962371200; 55586756200; 36079817200; 56022915400; 24376890800; 35278955600; 56739411100; 57196226681; 36523091800; 55756823600; 57216954378; 55712695800 | chungyc@jbnu.ac.kr; | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | PROG NEURO-PSYCHOPH | 0278-5846 | 1878-4216 | 103 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES;PHARMACOLOGY & PHARMACY;PSYCHIATRY | 2020 | 5.067 | 22.1 | 0.21 | 2025-06-25 | 8 | 9 | Antipsychotics; Rumination; First-episode psychosis; Full recovery | PSYCHOMETRIC PROPERTIES; RESPONSE STYLES; DEPRESSION; SCHIZOPHRENIA; SYMPTOMS; RECOVERY; DURATION; SCALE; WORRY | Antipsychotics; First-episode psychosis; Full recovery; Rumination | Adult; Antipsychotic Agents; Cohort Studies; Depressive Disorder; Exercise; Female; Follow-Up Studies; Humans; Male; Models, Statistical; Neuropsychological Tests; Psychotic Disorders; Republic of Korea; Treatment Outcome; Wounds and Injuries; Young Adult; neuroleptic agent; neuroleptic agent; adult; Article; Brooding Scale; clinical effectiveness; cognitive rumination; drug effect; drug efficacy; drug response; female; follow up; human; major clinical study; male; Positive and Negative Syndrome Scale; psychosis; rating scale; risk factor; treatment outcome; cohort analysis; complication; depression; exercise; injury; neuropsychological test; psychology; psychosis; South Korea; statistical model; young adult | English | 2020 | 2020-12-20 | 10.1016/j.pnpbp.2020.109983 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | EPIDEMIOLOGY OF CHILDHOOD IMMUNE THROMBOCYTOPENIA IN KOREA: INCIDENCE, PREVALENCE, AND AGE OF ONSET | Kim, Ji Yoon; Kim, Sung Eun | Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea | PEDIATRIC BLOOD & CANCER | PEDIATR BLOOD CANCER | 1545-5009 | 1545-5017 | 67 | SCIE | HEMATOLOGY;ONCOLOGY;PEDIATRICS | 2020 | 3.167 | 22.1 | 0 | English | 2020 | 2020-06 | 바로가기 | 바로가기 | |||||||||||||||||
| ○ | Meeting Abstract | Good Death Inventory: Perceptions on Good Death Among Parents of Pediatric Patients With Hematology-Oncology Disease in Advance | Kim, J. Y.; Kim, S. E. | Kyungpook Natl Univ Hosp, Pediat, Daegu, South Korea | Kim, Yong-Lim/AGK-3172-2022 | PEDIATRIC BLOOD & CANCER | PEDIATR BLOOD CANCER | 1545-5009 | 1545-5017 | 67 | SCIE | HEMATOLOGY;ONCOLOGY;PEDIATRICS | 2020 | 3.167 | 22.1 | 0 | English | 2020 | 2020-12 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Review | Molecular target: pan-AKT in gastric cancer | The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathway is involved in multiple cellular processes, including cell survival, proliferation, differentiation, metabolism and cytoskeletal reorganisation. The downstream effectors of this PI3K pathway are also essential for maintaining physiologic homeostasis, commonly dysregulated in most solid tumours. AKT is the key regulator in PI3K/AKT/mTOR signalling, interacting with multiple intracellular molecules. AKT activation subsequently leads to a number of potential downstream effects, and its aberrant activation results in the pathogenesis of cancer. Accordingly, as an attractive therapeutic target for cancer treatment, several AKT inhibitors are currently under development and in multiple stages of clinical trials for various types of malignancy, including gastric cancer (GC). Therefore, the authors review the significance of AKT and recent studies on AKT inhibitors in GC, focusing on the scientific background with the potential to improve treatment outcomes. | Kang, Byung Woog; Chau, Ian | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea; Royal Marsden Hosp, Dept Med, London, England; Royal Marsden Hosp, Dept Med, Sutton, Surrey, England | Chau, Ian/ABC-2023-2020 | 28567838500; 14526721100 | ian.chau@rmh.nhs.uk; | ESMO OPEN | ESMO OPEN | 2059-7029 | 5 | 5 | SCIE | ONCOLOGY | 2020 | 6.54 | 22.1 | 0.8 | 2025-06-25 | 39 | 41 | gastric cancer; AKT | PLACEBO PLUS PACLITAXEL; BREAST-CANCER; PI3K PATHWAY; DOUBLE-BLIND; PRECLINICAL PHARMACOLOGY; INHIBITOR IPATASERTIB; MUTATIONAL ANALYSIS; SIGNALING PATHWAY; PROSTATE-CANCER; ACTIVATED AKT | AKT; gastric cancer | Humans; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Stomach Neoplasms; afuresertib; biological marker; capivasertib; ipatasertib; miransertib; phosphatidylinositol 3 kinase; protein kinase B; uprosertib; phosphatidylinositol 3 kinase; protein kinase B; Akt signaling; cancer resistance; enzyme activation; human; nonhuman; protein targeting; Review; stomach cancer; treatment outcome; genetics; stomach tumor | English | 2020 | 2020-09 | 10.1136/esmoopen-2020-000728 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | SIROLIMUS FOR LIFE-THREATENING KAPOSIFORM HEMANGIOENDOTHELIOMA WITH KASABACH-MERRITT PHENOMENON | Kim, Ji Yoon; Kim, Sung Eun | Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea | PEDIATRIC BLOOD & CANCER | PEDIATR BLOOD CANCER | 1545-5009 | 1545-5017 | 67 | SCIE | HEMATOLOGY;ONCOLOGY;PEDIATRICS | 2020 | 3.167 | 22.1 | 0 | English | 2020 | 2020-06 | 바로가기 | 바로가기 | |||||||||||||||||
| ○ | ○ | Article | Synthesis and characterization of borate glasses for thermal neutron scintillation and imaging | With the aim of finding promising neutron scintillators, different compositions have been synthesized in the glassy phase and subsequently characterized for their performance as the scintillation screen of thermal neutron imaging systems. Three new compositions having Li, B, and Gd as principal constituents, doped with Eu have been synthesized by the melt quenching method and investigated the first time for neutron imaging in the present study. The concentration of luminescent activator, Eu3+ has been optimized by performing X-ray induced emission of these glass samples. Beam purity investigation along with the luminescence ability of the commercial screen have been also performed prior to the thorough evaluation of the thermal neutron scintillation characteristics of the compositions. The glass samples have been exposed to thermal neutrons for 5 and 10 min separately at the beam port of the research reactor for their performances in conventional direct film neutron radiography technique. The glasses containing Gd have been found to have higher light yield due to energy transfer from Gd ions to Eu activators. However, the composition of 60Li(2)O(3):10Y(2)O(3):28.5B(2)O(3):1.5Eu(2)O(3) (mol%) has been observed to have low light but good thermal neutron discrimination property from the gamma background despite having lesser X-ray luminescence among all three. | Saha, Sudipta; Kim, H. J.; Aryal, Pabitra; Tyagi, Mohit; Barman, Robin; Kaewkhao, J.; Kothan, S.; Kaewjaeng, S. | Kyungpook Natl Univ, Dept Phys, Daegu, South Korea; Bangladesh Atom Energy Commiss, Inst Nucl Sci & Technol, Dhaka, Bangladesh; Nakhon Pathom Rajabhat Univ, Ctr Excellence Glass Technol & Mat Sci CEGM, Muang 73000, Nakhon Pathom, Thailand; Chiang Mai Univ, Fac Associated Med Sci, Ctr Radiat Res & Med Imaging, Dept Radiol Technol, Chiang Mai 50200, Thailand | ; Tyagi, Mohit/T-2735-2019; Kim, Hong Joo/AAE-1178-2022 | 55935496600; 59051568100; 57196222852; 21234397100; 57338790900; 23974520300; 6507017165; 55871868200 | hongjoo@knu.ac.kr; | RADIATION MEASUREMENTS | RADIAT MEAS | 1350-4487 | 134 | SCIE | NUCLEAR SCIENCE & TECHNOLOGY | 2020 | 1.898 | 22.1 | 1.21 | 2025-06-25 | 12 | 14 | Neutron imaging; Scintillation screen; Glass; Optical density | RADIOGRAPHY | Glass; Neutron imaging; Optical density; Scintillation screen | Density (optical); Energy transfer; Europium; Gadolinium; Gamma rays; Glass; Light; Nuclear reactors; Scintillation; X ray radiography; X rays; Film neutron radiography; Luminescent activators; Melt quenching method; Neutron imaging; Neutron scintillator; Scintillation characteristics; Synthesis and characterizations; Thermal neutron imaging; Neutrons | English | 2020 | 2020-06 | 10.1016/j.radmeas.2020.106319 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A Deep CNN-Based Ground Vibration Monitoring Scheme for MEMS Sensed Data | Ground vibration monitoring with microelectromechanical systems (MEMS) sensors is very effective and promising for alerting geological disasters. In this letter, explicitly considering and effectively addressing several specific issues related to practical MEMS sensors, we develop a novel ground vibration monitoring scheme for MEMS sensed data based on a deep convolutional neural network (CNN). Experiments are then conducted on the synthetic and real data sets. Experimental results on both data sets demonstrate that the proposed scheme significantly outperforms the other comparable schemes. For the synthetic data set, the proposed scheme achieves a very high overall accuracy of 98.82%. Also, for the real data set, the proposed scheme achieves a high overall accuracy of 81.64%, which is about 7% higher than that reported in the literature. | Kang, Jae-Mo; Kim, Il-Min; Lee, Sangho; Ryu, Dong-Woo; Kwon, Jihoe | Sejong Univ, Sch Intelligent Mechatron Engn, Seoul 05006, South Korea; Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea; Queens Univ, Dept Elect & Comp Engn, Kingston, ON K7L 3N6, Canada; Korea Inst Geosci & Mineral Resources, Geosci Platform Div, Daejeon 34132, South Korea | 56024930400; 36040390300; 59846968800; 7103144212; 24479416200 | jaemo.kang@sejong.ac.kr;ilmin.kim@queensu.ca;energy@kigam.re.kr;dwryu@kigam.re.kr;jihoek@kigam.re.kr; | IEEE GEOSCIENCE AND REMOTE SENSING LETTERS | IEEE GEOSCI REMOTE S | 1545-598X | 1558-0571 | 17 | 2 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;GEOCHEMISTRY & GEOPHYSICS;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING | 2020 | 3.966 | 22.2 | 0.81 | 2025-06-25 | 9 | 10 | Micromechanical devices; Vibrations; Monitoring; Convolution; Feature extraction; Sensor phenomena and characterization; Convolutional neural network (CNN); deep learning; ground vibration; microelectromechanical systems (MEMS); sensed data | EARTHQUAKE MAGNITUDE PREDICTION | Convolutional neural network (CNN); deep learning; ground vibration; microelectromechanical systems (MEMS); sensed data | Convolution; Deep learning; Electromechanical devices; MEMS; Neural networks; Vibration measurement; Convolutional neural network; Geological disaster; Ground vibration; Ground vibration monitoring; Micro electromechanical system (MEMS); Overall accuracies; sensed data; Synthetic and real data; artificial neural network; data set; machine learning; monitoring system; remote sensing; satellite data; sensor; vibration; Deep neural networks | English | 2020 | 2020-02 | 10.1109/lgrs.2019.2918641 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | CORM-2-Solid Lipid Nanoparticles Maintain Integrity of Blood-Spinal Cord Barrier After Spinal Cord Injury in Rats | Spinal cord injury (SCI) is a devastating condition of the central nervous system that can lead to permanent motor and sensory deficits. Carbon monoxide-releasing molecule-2 (CORM-2) has been shown to have anti-inflammatory, anti-apoptotic, and angiogenic properties that may be useful for the treatment of SCI. However, it has a short carbon monoxide (CO) release half-life (approximately 1 min). To address this challenge, we developed a CORM-2-incorporated solid lipid nanoparticle (CORM-2-SLN) and evaluated its ameliorating effects for preventing blood-spinal cord barrier (BSCB) disruption and endothelial cell death following SCI. After a moderate compression injury of the spinal cord (compression with a 35-g impounder for 5 min), groups of rats were treated with a CORM-2-solution and CORM-2-SLNs at an equal dose of 10 mg/kg each via an intraperitoneal injection for 8 consecutive days. Behavior analysis was performed and animals were later sacrificed at different time points and evaluated for whether the CORM-2-SLNs prevented BSCB disruption and rescued endothelial cell damage following SCI. The CORM-2-SLN-treated group showed significantly diminished extravasation of Evans Blue dye with enhanced expression of tight junction proteins following SCI. Likewise, significantly diminished endothelial cell markers after SCI were optimally stabilized at 21 days. Additionally, lipopolysaccharide (LPS)-induced loss of tight junction integrity was significantly preserved after CORM-2-SLN treatment in human cerebral microvascular endothelial cell line (hCMEC/D3). Clinically, CORM-2-SLNs were associated with a significantly improved functional recovery, as compared with the CORM-2-solution. CORM-2-SLNs may help potentially to maintain BSCB integrity following SCI. | Joshi, Hari Prasad; Kumar, Hemant; Choi, Un Yong; Lim, Yong Cheol; Choi, Hyemin; Kim, Juri; Kyung, Jae Won; Sohn, Seil; Kim, Kyoung-Tae; Kim, Tin-Ki; Han, In-Bo | CHA Univ, Sch Med, CHA Bundling Med Ctr, Dept Neurosurg, 59 Yaptap Ro, Seongnam Si 13496, Gyeonggi Do, South Korea; Natl Inst Pharmaceut Educ & Res NIPER Ahmedabad, Dept Pharmacol & Toxicol, Gandhinagar, Gujarat, India; Ajou Univ Hosp, Dept Neurosurg, Suwon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Neurosurg, Daegu, South Korea; Hanyang Univ, Coll Pharm, Ansan 15588, Gyeonggi Do, South Korea; Hanyang Univ, Inst Pharmaceut Sci & Technol, Ansan 15588, Gyeonggi Do, South Korea | ; Kumar, Hemant/G-4576-2018 | 57201974279; 54949405700; 57209540640; 57212613160; 57193951350; 57205440229; 56895826800; 55047974500; 57201369790; 50061383600; 9338449900 | hanib@cha.ac.kr; | MOLECULAR NEUROBIOLOGY | MOL NEUROBIOL | 0893-7648 | 1559-1182 | 57 | 6 | SCIE | NEUROSCIENCES | 2020 | 5.59 | 22.2 | 1.95 | 2025-06-25 | 34 | 33 | Spinal cord injury; Carbon monoxide; Carbon monoxide-releasing molecule; Nanoparticle; Blood-spinal cord barrier; Angiogenesis | MONOXIDE-RELEASING MOLECULES; IMPROVES FUNCTIONAL RECOVERY; ACTIVATED PROTEIN-KINASE; CARBON-MONOXIDE; BRAIN-BARRIER; TRAUMATIC INJURY; DISRUPTION; PATHOPHYSIOLOGY; APOPTOSIS; CONSTRICTION | Angiogenesis; Blood-spinal cord barrier; Carbon monoxide; Carbon monoxide–releasing molecule; Nanoparticle; Spinal cord injury | Animals; Blood-Brain Barrier; Cell Line; Disease Models, Animal; Endothelial Cells; Female; Humans; Nanoparticles; Organometallic Compounds; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; antiinflammatory agent; carbon monoxide releasing molecule 2; cefazolin; Evans blue; ketoprofen; mitogen activated protein kinase; solid lipid nanoparticle; synaptophysin; tight junction protein; unclassified drug; nanoparticle; organometallic compound; tricarbonyldichlororuthenium (II) dimer; adult; animal experiment; animal model; animal tissue; antiinflammatory activity; apoptosis; Article; blood brain barrier; brain damage; cell death; cell disruption; controlled study; drug dosage form comparison; endothelium cell; enzyme phosphorylation; extravasation; female; hCMEC/D3 cell line; human; human cell; MAPK signaling; neuroprotection; nonhuman; protein depletion; rat; scar formation; spinal cord compression; spinal cord injury; tight junction; upregulation; animal; blood brain barrier; cell line; disease model; drug effect; spinal cord; Sprague Dawley rat | English | 2020 | 2020-06 | 10.1007/s12035-020-01914-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Acute Hyperglycemic Crises with Coronavirus Disease-19: Case Reports | Since the first case was contracted by coronavirus disease-19 (COVID-19) in Daegu, Korea in February 2020, about 6,800 cases and 130 deaths have been reported on April 9, 2020. Recent studies have reported that patients with diabetes showed higher mortality and they had a worse prognosis than the group without diabetes. In poorly controlled patients with diabetes, acute hyperglycemic crises such as diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS) also might be precipitated by COVID-19. Thus, intensive monitoring and aggressive supportive care should be needed to inadequately controlled patients with diabetes and COVID-19 infection. Here, we report two cases of severe COVID-19 patients with acute hyperglycemic crises in Korea. | Kim, Na-young; Ha, Eunyeong; Moon, Jun Sung; Lee, Yong-Hoon; Choi, Eun Young | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Endocrinol & Metab, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, 170 Hyeonchung Ro, Daegu 42415, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Pulm & Crit Care Med, 130 Dongdeok Ro, Daegu 41944, South Korea | id0121@naver.com;letact@yu.ac.kr; | DIABETES & METABOLISM JOURNAL | DIABETES METAB J | 2233-6079 | 2233-6087 | 44 | 2 | SCIE | ENDOCRINOLOGY & METABOLISM | 2020 | 5.376 | 22.3 | 73 | Acidosis; COVID-19; Diabetes complications; Hyperglycemia; Ketosis | English | 2020 | 2020-04 | 10.4093/dmj.2020.0091 | 바로가기 | 바로가기 | 바로가기 |
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