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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article Transcriptomic Changes Induced by Deletion of Transcriptional Regulator GCR2 on Pentose Sugar Metabolism in Saccharomyces cerevisiae Being a microbial host for lignocellulosic biofuel production, Saccharomyces cerevisiae needs to be engineered to express a heterologous xylose pathway; however, it has been challenging to optimize the engineered strain for efficient and rapid fermentation of xylose. Deletion of PHO13 (Delta pho13) has been reported to be a crucial genetic perturbation in improving xylose fermentation. A confirmed mechanism of the Delta pho13 effect on xylose fermentation is that the Delta pho13 transcriptionally activates the genes in the non-oxidative pentose phosphate pathway (PPP). In the current study, we found a couple of engineered strains, of which phenotypes were not affected by Delta pho13 (Delta pho13-negative), among many others we examined. Genome resequencing of the Delta pho13-negative strains revealed that a loss-of-function mutation in GCR2 was responsible for the phenotype. Gcr2 is a global transcriptional factor involved in glucose metabolism. The results of RNA-seq confirmed that the deletion of GCR2 (Delta gcr2) led to the upregulation of PPP genes as well as downregulation of glycolytic genes, and changes were more significant under xylose conditions than those under glucose conditions. Although there was no synergistic effect between Delta pho13 and Delta gcr2 in improving xylose fermentation, these results suggested that GCR2 is a novel knockout target in improving lignocellulosic ethanol production. Shin, Minhye; Park, Heeyoung; Kim, Sooah; Oh, Eun Joong; Jeong, Deokyeol; Florencia, Clarissa; Kim, Kyoung Heon; Jin, Yong-Su; Kim, Soo Rin Seoul Natl Univ, Res Inst Agr & Life Sci, Dept Agr Biotechnol, Seoul, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; Jeonju Univ, Dept Environm Sci & Biotechnol, Jeonju, South Korea; Purdue Univ, Dept Food Sci, Smith Hall, W Lafayette, IN 47907 USA; Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA; Korea Univ, Grad Sch, Dept Biotechnol, Seoul, South Korea Jeong, Deokyeol/GLR-8021-2022; Jin, Yong-Su/L-4530-2013; Kim, Soo Rin/X-2192-2019 57208401604; 57211334915; 36554561100; 59716734900; 57191332457; 56518188400; 34770896300; 57204009076; 36659584200 ysjin@illinois.edu;soorinkim@knu.ac.kr; FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY FRONT BIOENG BIOTECH 2296-4185 9 SCIE MULTIDISCIPLINARY SCIENCES 2021 6.064 21.0 0.4 2025-07-30 7 6 lignocellulosic biomass; yeast metabolic engineering; transcriptomics; glucose repression; GCR2; pentose phosphate pathway GCR2; glucose repression; lignocellulosic biomass; pentose phosphate pathway; transcriptomics; yeast metabolic engineering Cellulosic ethanol; Fermentation; Genes; Glucose; Lignocellulosic biomass; Metabolism; Biofuel production; Engineered strains; Glucose metabolism; Lignocellulosic ethanols; Synergistic effect; Transcriptional factors; Transcriptional regulator; Xylose fermentation; Yeast English 2021 2021-03-25 10.3389/fbioe.2021.654177 바로가기 바로가기 바로가기 바로가기
Article Transformation of Endophytic Bipolaris spp. Into Biotrophic Pathogen Under Auxin Cross-Talk With Brassinosteroids and Abscisic Acid Auxin is the reciprocal signaling molecule, which interferes with other phyto-hormonal and physiological processes during plant-microbes interaction. In this regard, Bipolaris spp., a growth-promoting endophytic fungus was used to inoculate pre-stressed Zea mays seedlings with yucasin (IAA inhibitor). The IAA-deficient host was heavily colonized by the endophyte that subsequently promoted the host growth and elevated the IAA levels with a peak value at 72 h. However, the seedling growth was inhibited later (i.e., at 120 h) due to the high levels of IAA that interfered with the activity of phytoalexins and brassinosteroids. Such interference also modulated the endophytic fungus from symbiotic to biotrophic pathogen that left the host plants defenseless. Yousaf, Muhammad Junaid; Hussain, Anwar; Hamayun, Muhammad; Iqbal, Amjad; Irshad, Muhammad; Kim, Ho-Youn; Lee, In-Jung Abdul Wali Khan Univ Mardan, Dept Bot, Mardan, Pakistan; Abdul Wali Khan Univ Mardan, Dept Food Sci & Technol, Mardan, Pakistan; Korea Inst Sci & Technol KIST, Smart Farm Res Ctr, Kangnung, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea Hamayun, Muhammad/B-1694-2010; Iqbal, Amjad/E-2010-2014; Kim, Soo/P-7880-2016; Yousaf, Muhammad Junaid/AAZ-4935-2021; Lee, In-Jung/GLS-0432-2022; Irshad, Muhammad/JQW-6402-2023; Hussain, Anwar/N-1605-2019 57739465900; 35621772200; 59297330100; 10142205100; 57206301341; 57191717301; 16425830900 drhussain@awkum.edu.pk;ijlee@knu.ac.kr; FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY FRONT BIOENG BIOTECH 2296-4185 9 SCIE MULTIDISCIPLINARY SCIENCES 2021 6.064 21.0 1.04 2025-07-30 12 13 symbiosis; phytohormones; yucasin; Zea mays; biotroph CELL-DEATH; PLANT; BIOSYNTHESIS; ANTIOXIDANT; INVOLVEMENT; STRESS; GROWTH; IAA biotroph; phytohormones; symbiosis; yucasin; Zea mays Forestry; Fungi; Abscisic acid; Brassinosteroids; Endophytic fungi; Peak values; Physiological process; Pre-stressed; Seedling growth; Signaling molecules; Crosstalk English 2021 2021-07-28 10.3389/fbioe.2021.657635 바로가기 바로가기 바로가기 바로가기
Article A short PEG linker alters the in vivo pharmacokinetics of trastuzumab to yield high-contrast immuno-PET images The prolonged blood circulation of the radiolabeled antibody conjugates is problematic when using immuno-PET imaging due to the increased radiation exposure and longer hospitalization required until sufficient contrast develops. In contrast to the prevailing belief that PEGylation prolongs blood retention time, we observed that a PEGylated antibody with a short PEG(8) linker cleared much faster from the blood while maintaining tumor uptake compared to its non-PEGylated counterpart. Breast tumors were clearly visualized with a very high tumor-to-background ratio as early as 24 h after injection in immuno-positron emission tomography (PET) imaging. Lee, Woonghee; Bobba, Kondapa Naidu; Kim, Jung Young; Park, Hyun; Bhise, Abhinav; Kim, Wanook; Lee, Kiwoong; Rajkumar, Subramani; Nam, Bora; Lee, Kyo Chul; Lee, Sang Hyuk; Ko, Sanghwan; Lee, Hye Jin; Jung, Sang Taek; Yoo, Jeongsoo Kyungpook Natl Univ, Sch Med, Dept Mol Med, Brain Korea 21 Four KNU Convergence Educ Program, Daegu 41944, South Korea; Korea Inst Radiol & Med Sci, Div Appl RI, Seoul 01812, South Korea; Kyungpook Natl Univ, Dept Chem, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, 80 Daehakro, Daegu 41566, South Korea; Korea Univ, Dept Biomed Sci, BK21 Grad Program, Coll Med, Seoul 02841, South Korea; Korea Univ, Inst Human Genet, Coll Med, Seoul 02841, South Korea Bhise, Abhinav/MVY-6473-2025; LEE, HYEJIN/W-1345-2018; Ko, Sanghwan/AAL-5474-2021; Kim, Kyunghoon/AGO-0079-2022; Jung, Sang/AAJ-9729-2021 55881469700; 56902497500; 7601371677; 56175671100; 57210174595; 57222364982; 57222365137; 57224804062; 57222734356; 42661704100; 55188583800; 56647428400; 56569175200; 54788991900; 8215136400 yooj@knu.ac.kr; JOURNAL OF MATERIALS CHEMISTRY B J MATER CHEM B 2050-750X 2050-7518 9 13 SCIE MATERIALS SCIENCE, BIOMATERIALS 2021 7.571 21.1 0.24 2025-07-30 21 17 Antineoplastic Agents, Immunological; Breast Neoplasms; Female; Humans; Polyethylene Glycols; Positron-Emission Tomography; Radiopharmaceuticals; Trastuzumab; Blood; Medical imaging; Monoclonal antibodies; Tumors; immunological antineoplastic agent; macrogol; radiopharmaceutical agent; trastuzumab; Antibody conjugate; Blood circulation; High contrast; Positron emission tomography (PET); Radiation Exposure; Retention time; Tumor to background ratios; Tumor uptake; breast tumor; chemistry; diagnostic imaging; female; human; metabolism; positron emission tomography; Positron emission tomography English 2021 2021-04-07 10.1039/d0tb02911d 바로가기 바로가기 바로가기 바로가기
Correction A short PEG linker alters the in vivo pharmacokinetics of trastuzumab to yield high-contrast immuno-PET images (vol 9, 2995, 2021) Lee, Woonghee; Bobba, Kondapa Naidu; Kim, Jung Young; Park, Hyun; Bhise, Abhinav; Kim, Wanook; Lee, Kiwoong; Rajkumar, Subramani; Nam, Bora; Lee, Kyo Chul; Lee, Sang Hyuk; Ko, Sanghwan; Lee, Hye Jin; Jung, Sang Taek; Yoo, Jeongsoo Kyungpook Natl Univ, Sch Med, Dept Mol Med, Brain Korea 21 Four KNU Convergence Educ Program, Daegu 41944, South Korea; Korea Inst Radiol & Med Sci, Div Appl RI, Seoul 01812, South Korea; Kyungpook Natl Univ, Dept Chem, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, 80 Daehakro, Daegu 41566, South Korea; Korea Univ, Coll Med, Dept Biomed Sci, BK21 Grad Program, Seoul 02841, South Korea; Korea Univ, Coll Med, Inst Human Genet, Seoul 02841, South Korea Bhise, Abhinav/MVY-6473-2025; Ko, Sanghwan/AAL-5474-2021; Kim, Kyunghoon/AGO-0079-2022; Jung, Sang/AAJ-9729-2021; LEE, HYEJIN/W-1345-2018 55881469700; 56902497500; 7601371677; 56175671100; 57210174595; 57222364982; 57222365137; 57224804062; 57222734356; 42661704100; 55188583800; 56647428400; 56569175200; 54788991900; 8215136400 yooj@knu.ac.kr; JOURNAL OF MATERIALS CHEMISTRY B J MATER CHEM B 2050-750X 2050-7518 9 30 SCIE MATERIALS SCIENCE, BIOMATERIALS 2021 7.571 21.1 1.36 2025-07-30 1 1 erratum English 2021 2021-08-14 10.1039/d1tb90111g 바로가기 바로가기 바로가기 바로가기
Article A TDMA-Based Data Gathering Protocol for Molecular Communication via Diffusion-Based Nano-Sensor Networks This paper explores the application of molecular communication via diffusion-based nano-sensor networks (MCSNs) for data gathering applications in in-body medical systems. For MCSNs, the large and varying propagation delay in the channel presents a fundamental challenge for channel access, leading to packet collisions. Although packet collisions are well-studied for traditional wireless sensor networks, to date, there are no such studies conducted for MCSNs. Another fundamental challenge is the limited capabilities of the nano-sensors, rendering the existing solutions inefficient. Therefore, a novel light-weight time-division multiple access (TDMA)-based data gathering multiple access control (MAC) protocol is proposed. Light-weight here implies that long information, such as timestamps, is not exchanged. TDMA-based here implies that each nano-sensor is designated an exclusive time-slot. The lack of a channel model for spherical transmitters impairs theoretical analysis of the probability of packet collisions. To overcome this, the propagation delay is approximated as a Normal distribution. The model is validated using the widely popular particle-based simulation, which is also used to determine the packet duration considering ON-OFF shift keying. Building upon these analyses, a system-level simulator is developed to evaluate the proposed MAC protocol. For the first time, the packet collision probability is characterized under varied distances and diffusion coefficients. A key finding is the correlation between the channel utilization and the time-slot occupancy ratio, which can be used as a tool to optimize the performance of an MCSN. Finally, comparisons with conventional TDMA reveals that the proposed protocol can offer better performance. Shitiri, Ethungshan; Cho, Ho-Shin Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea Shitiri, Ph.D., Ethungshan/Z-5918-2019 57190818428; 35316924900 ethungshan@ee.knu.ac.kr;hscho@ee.knu.ac.kr; IEEE SENSORS JOURNAL IEEE SENS J 1530-437X 1558-1748 21 17 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION;PHYSICS, APPLIED 2021 4.325 21.1 0.63 2025-07-30 9 10 Propagation delay; Time division multiple access; Protocols; Media Access Protocol; Sensors; Molecular communication (telecommunication); Sensor phenomena and characterization; Data gathering; molecular communications; multiple access control; packet collisions; nano-sensor networks; time division multiple access TARGETED DRUG-DELIVERY; CLOCK SYNCHRONIZATION; MODULATION TECHNIQUES; MAC PROTOCOLS; TRANSMITTER; PERFORMANCE; RELEASE; DESIGN; ACCESS Data gathering; molecular communications; multiple access control; nano-sensor networks; packet collisions; time division multiple access Data communication systems; Diffusion; Medium access control; Nanosensors; Normal distribution; Wireless sensor networks; Data gathering protocols; Molecular communication; Multiple access control protocol; Packet collision probability; Particle-based simulation; System level simulator; Time division multiple accesses (TDMA); Varying propagation delays; Time division multiple access English 2021 2021-09-01 10.1109/jsen.2021.3091494 바로가기 바로가기 바로가기 바로가기
Article Ameliorative effect of indole-3-acetic acid- and siderophore-producing Leclercia adecarboxylata MO1 on cucumber plants under zinc stress This study investigated the plant growth-promoting effects of Leclercia adecarboxylata MO1 for Zn stress mitigation and plant growth improvement in Zn-contaminated soil. Results demonstrated that L. adecarboxylata MO1 produced siderophores that could solubilize Zn and silicate, had a tolerance to elevated levels of Zn supplementation (2 and 5 mM) in growth mediums, and produced significant amounts of indole-3-acetic acid (IAA). It was also found to promote plant growth under both control conditions and Zn toxicity (2 and 5 mM). Furthermore, L. adecarboxylata MO1 positively regulated physiochemical attributes by decreasing hydrogen peroxide (H2O2) and Zn uptake in both roots and shoots, improving antioxidant systems (e.g. catalase (CAT), peroxidase (POD), polyphenol peroxidase (PPO), superoxide anion (SOA), lipid peroxidation (MDA), and glutathione (GSH)), and reducing stress-responsive endogenous abscisic acid (ABA) and salicylic acid (SA) in plants grown under Zn toxicity of 2 and 5 mM, compared with non-inoculated plants. Kang, Sang-Mo; Shahzad, Raheem; Khan, Muhammad Aaqil; Hasnain, Zuhair; Lee, Ko-Eun; Park, Hee-Soon; Kim, Lee-Rang; Lee, In-Jung Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Univ Haripur, Dept Hort, Haripur, Pakistan; PMAS Arid Agr Univ, Dept Agron, Rawalpindi, Pakistan Shahzad, Raheem/AAG-8370-2019; Kang, Sang-Mo/MBG-7823-2025; Lee, In-Jung/GLS-0432-2022; Khan, Muhammad/ABB-9797-2021 56189696900; 56454250900; 57188585606; 36600343900; 56191302700; 57221647343; 57221646797; 16425830900 ijlee@knu.ac.kr; JOURNAL OF PLANT INTERACTIONS J PLANT INTERACT 1742-9145 1742-9153 16 1 SCIE PLANT SCIENCES 2021 4.029 21.1 3.55 2025-07-30 33 38 Plant growth-promoting rhizospheric microbe; indole-3-acetic acid; Zn toxicity; antioxidants; abscisic acid; salicylic acid BACILLUS-AMYLOLIQUEFACIENS RWL-1; GROWTH-PROMOTING RHIZOBACTERIA; PHYSIO-HORMONAL CHANGES; HEAVY-METALS; ENDOPHYTIC BACTERIA; SOLUBILIZING BACTERIA; SALICYLIC-ACID; CADMIUM STRESS; TOLERANCE; SALINITY abscisic acid; antioxidants; indole-3-acetic acid; Plant growth-promoting rhizospheric microbe; salicylic acid; Zn toxicity English 2021 2021-01-01 10.1080/17429145.2020.1864039 바로가기 바로가기 바로가기 바로가기
Article Aspergillus Flavus reprogrammed morphological and chemical attributes of Solanum lycopersicum through SlGSH1 and SlPCS1 genes modulation under heavy metal stress Cadmium (Cd) and chromium (Cr) in agricultural soils is becoming a serious threat in tomato. The complete removal of these heavy metals (HMs) from contaminated soil is challenging. However, the use of plant endophytes might be beneficial. The pragmatic role of endophytic fungi Aspergillus flavus (Ch-01) in tomato under Cd and Cr stress was, therefore, investigated. A. flavus enhanced growth attributes in tomato seedlings under Cd and Cr stress. Besides, it remediated Cd and Cr toxicity by reducing their translocation from the roots to the upper part of the tomato plants. In fact, A. flavus associated plants developed tolerance against Cd and Cr toxicity via the expression of SlGSH1 and SlPCS1 genes. Both genes helped in metal chelation and mitigation of Cd and Cr toxicity. From the results, it is concluded that A. flavus is a plant growth promoting and HMs alleviating endophyte, hence it might be used as a biofertilizer. Aziz, Laila; Hamayun, Muhammad; Rauf, Mamoona; Iqbal, Amjad; Husssin, Anwar; Khan, Sumera Afzal; Irshad, Muhammad; Lee, In-jung Abdul Wali Khan Univ Mardan, Dept Bot, Garden Campus, Mardan 23200, Pakistan; Abdul Wali Khan Univ Mardan, Dept Food Sci & Technol, Mardan, Pakistan; Univ Peshawar, Ctr Biotechnol & Microbiol, Peshawar, Pakistan; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea Lee, In-Jung/GLS-0432-2022; Khan, Abdul/H-5910-2011; Irshad, Muhammad/JQW-6402-2023; Iqbal, Amjad/E-2010-2014; Rauf, Mamoona/AAC-3246-2019; rauf, mamoona/AAC-3246-2019; Hamayun, Muhammad/B-1694-2010 57222572212; 59297330100; 55609311400; 10142205100; 57222571663; 9636646900; 57206301341; 16425830900 hamayun@awkum.edu.pk;ijlee@knu.ac.kr; JOURNAL OF PLANT INTERACTIONS J PLANT INTERACT 1742-9145 1742-9153 16 1 SCIE PLANT SCIENCES 2021 4.029 21.1 2.13 2025-07-30 18 25 Solanum lycopersicum; Aspergillus flavus (Ch-01); heavy metal stress; IAA SlGSH1; SlPCS1 PLANT-GROWTH; ENDOPHYTIC FUNGI; TOLERANCE; EXPRESSION; SUNFLOWER; TOXICITY; CD Aspergillus flavus (Ch-01); heavy metal stress; IAA SlGSH1; SlPCS1; Solanum lycopersicum English 2021 2021-01-01 10.1080/17429145.2021.1903105 바로가기 바로가기 바로가기 바로가기
Article Blockchain-Enabled Certificate-Based Authentication for Vehicle Accident Detection and Notification in Intelligent Transportation Systems As the communications among the vehicles, the Road-Side Units (RSU) and the Edge Servers (ES) take place via wireless communication and the Internet, an adversary may take the opportunity to tamper with the data communicated among various entities in an Internet of Vehicles (IoV) environment. Therefore, it demands secure communication among the involved entities in an IoV-based Intelligent Transportation System (ITS) deployment. In this work, we design a new blockchain-enabled certificate-based authentication scheme for vehicle accident detection and notification in ITS, called BCAS-VADN. In BCAS-VADN, through the authentication process, each vehicle can securely notify accident related transactions to its nearby Cluster Head (CH), if an accident is detected on roads either by its own or neighbor vehicle(s). The CH then securely sends the transactions received from the vehicles to its RSU and subsequently, these transactions are also received securely by the ESs. The ES is responsible for preparing partial block containing transactions and Merkle tree root, and a digital signature on those information, and then forwarding to its associated Cloud Server (CS) in the Blockchain Center (BC) for complete block creation, verification and addition of the block using the designed consensusprocess. Due to blockchain technology usage, it is shown that BCAS-VADN is not only secure against various potential attacks, but also maintains transparency, immutability and decentralizationof the information. Furthermore, a comprehensive comparative analysis reveals that BCAS-VADN achieves better security and more functionality attributes, and has low communication and computational overheads as compared to other competitive authentication schemes in IoV. In addition, the practical demonstration using the blockchain technology has been also provided. Vangala, Anusha; Bera, Basudeb; Saha, Sourav; Das, Ashok Kumar; Kumar, Neeraj; Park, Youngho Int Inst Informat Technol, Ctr Secur Theory & Algorithm Res, Hyderabad 500032, India; Thapar Univ, Dept Comp Sci & Engn, Patiala 147004, Punjab, India; Asia Univ, Dept Comp Sci & Informat Engn, Taichung 41354, Taiwan; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea ; Kumar, Neeraj/L-3500-2016; Das, Ashok Kumar/U-2790-2019; Saha, Sourav/LSL-9012-2024; Vangala, Anusha/AAF-8154-2021; VANGALA, ANUSHA/AAF-8154-2021; Bera, Basudeb/ACC-6233-2022 57201194546; 57214777647; 57207760870; 55450732800; 57206866080; 56962990300 anusha.vangala@research.iiit.ac.in;basudeb.bera@research.iiit.ac.in;sourav.saha@research.iiit.ac.in;ashok.das@iiit.ac.in;neeraj.kumar@thapar.edu;parkyh@knu.ac.kr; IEEE SENSORS JOURNAL IEEE SENS J 1530-437X 1558-1748 21 14 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION;PHYSICS, APPLIED 2021 4.325 21.1 6.64 2025-07-30 69 95 Intelligent transportation systems; authentication; vehicle accident detection; vehicle accident notification; blockchain; security KEY AGREEMENT PROTOCOL; USER AUTHENTICATION; SCHEME; INTERNET; PRIVACY; SECURITY; CHALLENGES; BIOMETRICS authentication; blockchain; Intelligent transportation systems; security; vehicle accident detection; vehicle accident notification Authentication; Blockchain; Intelligent systems; Intelligent vehicle highway systems; Vehicle to vehicle communications; Vehicles; Authentication scheme; Certificate-based; Comparative analysis; Computational overheads; Intelligent transportation systems; Technology usages; Vehicle accidents; Wireless communications; Accidents English 2021 2021-07-15 10.1109/jsen.2020.3009382 바로가기 바로가기 바로가기 바로가기
Review Designed protein- and peptide-based hydrogels for biomedical sciences Proteins are fundamentally the most important macromolecules for biochemical, mechanical, and structural functions in living organisms. Therefore, they provide us with diverse structural building blocks for constructing various types of biomaterials, including an important class of such materials, hydrogels. Since natural peptides and proteins are biocompatible and biodegradable, they have features advantageous for their use as the building blocks of hydrogels for biomedical applications. They display constitutional and mechanical similarities with the native extracellular matrix (ECM), and can be easily bio-functionalized via genetic and chemical engineering with features such as bio-recognition, specific stimulus-reactivity, and controlled degradation. This review aims to give an overview of hydrogels made up of recombinant proteins or synthetic peptides as the structural elements building the polymer network. A wide variety of hydrogels composed of protein or peptide building blocks with different origins and compositions - including beta-hairpin peptides, alpha-helical coiled coil peptides, elastin-like peptides, silk fibroin, and resilin - have been designed to date. In this review, the structures and characteristics of these natural proteins and peptides, with each of their gelation mechanisms, and the physical, chemical, and mechanical properties as well as biocompatibility of the resulting hydrogels are described. In addition, this review discusses the potential of using protein- or peptide-based hydrogels in the field of biomedical sciences, especially tissue engineering. Ahn, Wonkyung; Lee, Jong-Hwan; Kim, Soo Rin; Lee, Jeewon; Lee, Eun Jung Kyungpook Natl Univ, Sch Appl Chem Engn, Dept Chem Engn, Daegu 41566, South Korea; Korea Univ, Dept Chem & Biol Engn, Seoul 02841, South Korea; Korea Res Inst Chem Technol, Ctr Convergent Res Emerging Virus Infect, Daejeon 34114, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea Kim, Soo Rin/X-2192-2019; lee, sang/Q-4650-2019; Lee, Eun-Jung/HDN-0608-2022 57222252868; 56493307000; 36659584200; 7601480997; 57239965200 soorinkim@knu.ac.kr;leejw@korea.ac.kr;eunjunglee@knu.ac.kr; JOURNAL OF MATERIALS CHEMISTRY B J MATER CHEM B 2050-750X 2050-7518 9 8 SCIE MATERIALS SCIENCE, BIOMATERIALS 2021 7.571 21.1 0.99 2025-07-30 58 56 ELASTIN-LIKE POLYPEPTIDES; SILK FIBROIN HYDROGEL; RESILIN-BASED MATERIALS; CROSS-LINKED COLLAGEN; RUBBER-LIKE PROTEIN; IN-VITRO EVALUATION; MECHANICAL-PROPERTIES; EXTRACELLULAR-MATRIX; CELL-ADHESION; BIODEGRADABLE HYDROGELS Animals; Biocompatible Materials; Drug Design; Humans; Hydrogels; Peptides; Proteins; Biocompatibility; Biology; Elastin; Gelation; Hydrogels; Medical applications; Recombinant proteins; Tissue engineering; biomaterial; peptide; protein; Biomedical applications; Controlled degradation; Gelation mechanisms; Helical coiled-coil; Native extracellular matrix; Structural buildings; Structural elements; Structural function; animal; chemistry; drug design; human; hydrogel; pharmacology; Peptides English 2021 2021-02-28 10.1039/d0tb02604b 바로가기 바로가기 바로가기 바로가기
Article Development of an Equivalent Circuit of a Cymbal Transducer The cymbal transducer is a miniature transducer developed from the class V flextensional transducer. Many studies to analyze this transducer have been conducted using either the finite element method or fabrication and measurement technique. Meanwhile, the equivalent circuit method is a relatively simpler, faster, and more efficient approach to conduct performance analysis of an electromechanical transducer compared with these two methods. However, despite this merit, an accurate equivalent circuit model has not been introduced for the cymbal transducer, yet. In this study, we developed a novel equivalent circuit that can accurately depict the characteristics of the cymbal transducer and enable its efficient performance evaluation. The equivalent circuit was first divided into several parts according to the structure of the transducer. Thereafter, the electromechanical and vibration characteristics of each part were analyzed to derive the values of the circuit parameters corresponding to the part. The validity of the circuit parameters was verified by comparing the impedance calculated with the circuit comprising the parameters and that measured with prototype transducers. Additional analysis of the transmitting voltage response of the transducer further confirmed the efficacy and accuracy of the developed equivalent circuit in characterizing the cymbal transducer. The new equivalent circuit developed in this work can facilitate the design and analysis of not only individual cymbal transducers but also their large arrays. Shim, Hayeong; Roh, Yongrae Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea 57202806954; 7102361870 yryong@knu.ac.kr; IEEE SENSORS JOURNAL IEEE SENS J 1530-437X 1558-1748 21 12 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION;PHYSICS, APPLIED 2021 4.325 21.1 0.86 2025-07-30 13 13 Transducers; Equivalent circuits; Finite element analysis; Impedance; Metals; Strain; Resonant frequency; Cymbal transducer; equivalent circuit; finite element method; impedance; transmitting voltage response IV FLEXTENSIONAL TRANSDUCER; MODEL Cymbal transducer; equivalent circuit; finite element method; impedance; transmitting voltage response Electric network analysis; Electric network parameters; Timing circuits; Transducers; Vibration analysis; Electro-mechanical transducers; Equivalent circuit method; Equivalent circuit model; Flextensional transducers; Measurement techniques; Performance analysis; Transmitting voltage response; Vibration characteristics; Equivalent circuits English 2021 2021-06-15 10.1109/jsen.2021.3071768 바로가기 바로가기 바로가기 바로가기
Article Discovery of novel phenaleno isoquinolinium-based fluorescence imaging agents for sentinel lymph node mapping Fluorescence imaging agents have recently received huge attention due to their important role in disease diagnostics. However, the intrinsic problems of these probes, such as complex synthetic routes and high molecular weight, remain challenging. Here, we developed novel phenaleno isoquinolinium-based fluorescent agents, Medical Fluorophores 37-41 (MF37-41), applicable to the quantitative and sensitive detection of sentinel lymph nodes (SLNs). These imaging agents showed no adverse effects on the proliferation of immune and normal cells and did not induce in vivo toxicity. In vivo fluorescence lifetime imaging demonstrated the accumulation of phenaleno isoquinolinium salts in the SLNs of nude mice within 15 min postinjection, consistent with our biodistribution findings. These results suggest that phenaleno isoquinolinium salts are feasible fluorescence imaging agents that can be used as potential lymphatic tracers. Han, Ye Ri; Lee, Da-Sol; Lee, Sang Bong; Jeon, Hui-Jeon; Lee, Sijoon; Sung, Soo-Eun; Lee, Chang-Hee; Cho, Sung Jin; Kim, Kil Soo; Kim, Dong-Su; Jeon, Yong Hyun Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 700721, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 700721, South Korea; Gyeongbuk Inst Bio Ind, Vaccine Commercializat Ctr, 88 Saneopdanji Gil, Andong Si 33618, Gyeongbuk, South Korea; Yonsei Univ, Dept Chem, 50 Yonsei Ro, Seoul 03722, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Korea Res Inst Chem Technol, Therapeut & Biotechnol Div, 141 Gajeongro, Yuseong 31414, Daejeon, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu, South Korea Kim, Seung/N-5248-2019; Lee, Sijoon/LIC-1291-2024; Kim, Dong-Su/M-6819-2017; Han, Ye/ABB-5644-2020 57327672500; 57226045679; 57190304501; 57193694479; 57219164019; 56051194000; 56456838400; 58735369700; 35272034300; 57223664495; 16042453400 dskim82@krict.re.kr;jeon9014@gmail.com; JOURNAL OF MATERIALS CHEMISTRY B J MATER CHEM B 2050-750X 2050-7518 9 48 SCIE MATERIALS SCIENCE, BIOMATERIALS 2021 7.571 21.1 0.18 2025-07-30 4 4 INDOCYANINE GREEN FLUORESCENCE; BIOPSY; ANNULATION; ALKYNES; TRIAL Animals; Biocompatible Materials; Cell Line; Cricetulus; Drug Discovery; Fluorescent Dyes; Injections, Intravenous; Isoquinolines; Materials Testing; Mice; Molecular Structure; Optical Imaging; Phenalenes; Sentinel Lymph Node; Diagnosis; Mammals; Salts; biomaterial; fluorescent dye; isoquinoline derivative; phenalene derivative; Disease diagnostics; Fluorescence imaging; Fluorescent agents; High molecular weight; Imaging agent; Quantitative detection; Sensitive detection; Sentinel lymph node mapping; Sentinel lymph nodes; Synthetic routes; animal; cell line; chemical structure; chemistry; Cricetulus; diagnostic imaging; drug development; fluorescence imaging; intravenous drug administration; materials testing; mouse; sentinel lymph node; synthesis; Fluorescence imaging English 2021 2021-12-15 10.1039/d1tb02146j 바로가기 바로가기 바로가기 바로가기
Article Enhanced Stability and Sensitivity of AlGaN/GaN-HEMTs pH Sensor by Reference Device To improve the stability and sensitivity of pH sensors based on AlGaN/GaN high electron mobility transistors (HEMTs), we proposed a modified sensing structure by integrating a reference HEMT device. This structural pH sensor exhibits a typical Nernstian behavior with a sensitivity of 54.38 mV/pH, which is higher than the value of 49.43mV/pH derived from the AlGaN/GaN HEMT-based sensor without integrating the reference HEMTs device. Furthermore, the stability of the new structural sensor is enhanced by approximately 19.2 in comparison with that of its traditional counterpart. The improved performances are analyzed using an electrical double-layer model together with an equivalent circuit model, and we find that the new sensor structure has a larger capacitor and exhibits a better rectification effect, hence decreasing the electrical noise and enhancing the stability of the testing signal. Meanwhile, the new sensor structure displays a smaller equivalent resistance and results in a larger available output current, hence exhibiting a higher sensitivity. Dong, Yan; Wang, Rui; Xie, Zili; Liu, Yanli; Lei, Jianming; Guo, Hui; Dai, Quan; Kim, Jeong-Gil; Kang, Seung-Hyeon; Won, Chul-Ho; Lee, Jung-Hee; Chen, Dunjun; Zhang, Rong; Zheng, Youdou Nanjing Univ, Sch Elect Sci & Engn, Nanjing 210093, Peoples R China; Shandong Technol & Business Univ, Sch Informat & Elect Engn, Yantai 264005, Peoples R China; Nanjing Univ Vocat Ind Technol, Sch Elect Engn, Nanjing 210023, Peoples R China; Kyungpook Natl Univ, Sch Elect Engn, Daegu 702701, South Korea Chen, Wei/GZK-7348-2022; Liu, Yanli/D-3224-2017; guo, hui/KRO-5200-2024 57195918118; 59722775600; 13606640900; 55330107100; 57200657488; 57226886078; 57200146404; 57203324876; 57194147812; 8839784000; 57196140713; 8360190800; 55570248000; 7404836634 yandong199@smail.nju.edu.cn;djchen@nju.edu.cn; IEEE SENSORS JOURNAL IEEE SENS J 1530-437X 1558-1748 21 8 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION;PHYSICS, APPLIED 2021 4.325 21.1 0.7 2025-07-30 8 9 Sensors; Wide band gap semiconductors; Aluminum gallium nitride; MODFETs; HEMTs; Gallium nitride; Circuit stability; pH sensor; two-dimensional electronic gas; AlGaN; GaN heterostructure; reference device; stability; sensitivity DOUBLE-LAYER; MODEL; ELECTRODES; ION AlGaN/GaN heterostructure; pH sensor; reference device; sensitivity; stability; two-dimensional electronic gas Aluminum gallium nitride; Electric rectifiers; Equivalent circuits; Gallium nitride; High electron mobility transistors; III-V semiconductors; pH; Stability; Algan/gan high electron-mobility transistors; Electrical double layers; Enhanced stability; Equivalent circuit model; Equivalent resistance; Rectification effects; Reference devices; Sensor structures; pH sensors English 2021 2021-04-15 10.1109/jsen.2020.3047204 바로가기 바로가기 바로가기 바로가기
Article Genetic Algorithm for Path Loss Model Selection in Signal Strength-Based Indoor Localization Ranging methods using received signal strength (RSS) information are widely used for indoor localization because they can be easily implemented without conducting site surveys. However, range estimation with a single pathloss model produces considerable errors, which degrade the positioning performance. This problem mainly arises because the single pathloss model cannot reflect diverse indoor radio wave propagation characteristics. In this study, we develop a new overlapping multi-state model to consider multiple candidates of pathloss models including line-of-sight (LOS) and non-line-of-sight (NLOS) states, and propose an efficient way to select a proper model for each reference node involved in the localization process. To this end, we formulate a cost function whose value varies widely depending on the choice of pathloss model of each access point. Because the computational complexity to find an optimal channel model for each reference node exponentially increases with the number of reference nodes, we apply a genetic algorithm to significantly reduce the complexity so that the proposed method can be executed in real-time. Experimental validations with ray-tracing simulations and RSS measurements at a real site confirm the improvement of localization accuracy for Wi-Fi in indoor environments. The proposed method achieves up to 1.92 m mean positioning error under a practical indoor environment and produces a performance improvement of 31.09% over the benchmark scenario. Lee, Byeong-ho; Ham, Doyoung; Choi, Jeongsik; Kim, Seong-Cheol; Kim, Yong-Hwa Seoul Natl Univ, Dept Elect & Comp Engn, Seoul 08826, South Korea; Seoul Natl Univ, Inst New Media & Commun, Seoul 08826, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Korea Natl Univ Transportat, Dept Data Sci, Uiwang Si 16106, Gyeonggi Do, South Korea Choi, Jeongsik/ABA-6906-2020 57195528668; 57255590800; 58534394200; 22334016200; 55976343900 bhlee@maxwell.snu.ac.kr;wj2dy@maxwell.snu.ac.kr;jeongsik.choi@knu.ac.kr;sckim@maxwell.snu.ac.kr;yongkim@ut.ac.kr; IEEE SENSORS JOURNAL IEEE SENS J 1530-437X 1558-1748 21 21 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION;PHYSICS, APPLIED 2021 4.325 21.1 2.03 2025-07-30 25 32 Location awareness; Distance measurement; Wireless fidelity; Indoor environment; Genetic algorithms; Attenuation; Standards; Received signal strength; indoor localization; path loss model; trilateration; genetic algorithm; Wi-Fi RSS-BASED LOCALIZATION; INTERNET genetic algorithm; indoor localization; path loss model; Received signal strength; trilateration; Wi-Fi Benchmarking; Cost functions; Indoor positioning systems; Location; Radio waves; Ray tracing; Wave propagation; Wi-Fi; Wireless local area networks (WLAN); Attenuation; Indoor environment; Indoor localization; Location awareness; Model Selection; Path loss models; Received signal strength; Reference nodes; Trilateration; Wireless fidelities; Genetic algorithms English 2021 2021-11-01 10.1109/jsen.2021.3110971 바로가기 바로가기 바로가기 바로가기
Article Novel quinoline-based fluorescent bioimaging probe, KSNP117, for sentinel lymph node mapping Fluorescent imaging agents with biocompatibility and high sensitivity are urgently required for the accurate detection of sentinel lymph nodes (SLNs). Herein, we report the design of a novel quinoline-based fluorescent probe, designated KSNP117, which can be applied as a biomedical imaging agent in the sensitive and quantitative detection of SLNs. KSNP117 exerted no adverse effects on the proliferation of ovary and immune cells and also showed excellent serum stability with photo-brightening effects. In vivo fluorescent imaging revealed the accumulation of KSNP117 in the SLNs of nude mice within 10 min post injection, without in vivo toxicity, which was consistent with the findings of ex vivo imaging. These results support the potential of KSNP117 as a promising lymphatic tracer for biomedical imaging applications. Elbatrawy, Ahmed A.; Lee, Da Sol; Lee, Sang Bong; Jeon, Hui-Jeon; Lee, Sijoon; Kang, Kyung-ku; Sung, Soo-Eun; Han, Ye Ri; Cho, Sung Jin; Kim, Dong-Su; Kim, Kil Soo; Nam, Ghilsoo; Jeon, Yong Hyun Korea Inst Sci & Technol, Brain Sci Inst, Ctr Neuromed, Seoul, South Korea; Korea Univ Sci & Technol UST, KIST Sch, Div Biomed, Gajeong Ro 217, Daejeon 34113, South Korea; Daegu Gyeongbuk Med Innovat Fdn Daegu, Lab Anim Ctr, Daegu 700721, South Korea; Gyeongbuk Inst Bioind, Vaccine Commercializat Ctr, 5 Ind 2nd St, Andong 36618, Gyeongsangbuk D, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 700721, South Korea; Korea Res Inst Chem Technol, Therapeut & Biotechnol Div, 141 Gajeongro, Daejeon 34114, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu, South Korea Lee, Sijoon/LIC-1291-2024; Han, Ye/ABB-5644-2020; Kim, Dong-Su/M-6819-2017; Lee, Sang/I-8954-2014; Kim, Seung/N-5248-2019 57190383036; 57226045679; 57190304501; 57193694479; 57219164019; 57215079376; 56051194000; 56394859200; 58735369700; 57223664495; 35272034300; 7003446458; 16042453400 gsnam@kist.re.kr;jeon9014@gmail.com; JOURNAL OF MATERIALS CHEMISTRY B J MATER CHEM B 2050-750X 2050-7518 9 24 SCIE MATERIALS SCIENCE, BIOMATERIALS 2021 7.571 21.1 0.18 2025-07-30 4 4 INDOCYANINE GREEN FLUORESCENCE; QUANTUM DOTS; BIOPSY; TRIAL; FOCUS Animals; Female; Fluorescent Dyes; Male; Mice; Optical Imaging; Quinolines; Sentinel Lymph Node; Biocompatibility; Mammals; Medical imaging; Probes; fluorescent dye; quinoline derivative; Biomedical imaging; Biomedical imaging applications; Fluorescent bioimaging; Fluorescent imaging agents; Fluorescent probes; Quantitative detection; Sentinel lymph node mapping; Sentinel lymph nodes; animal; chemistry; diagnostic imaging; female; fluorescence imaging; male; mouse; procedures; sentinel lymph node; Fluorescence imaging English 2021 2021-06-28 10.1039/d1tb00568e 바로가기 바로가기 바로가기 바로가기
Article Visualization of platelet recruitment to tumor lesions using highly sensitive and stable radioiodine studded gold nanoprobes In vivo imaging of platelets will provide a better understanding of their critical roles in arterial cardiovascular disease, hemostasis, inflammation, and cancer. Here, we demonstrate the feasibility of using radioiodine studded gold nanoprobes (RIS-GNPs) as a platelet tracker for nuclear medicine imaging in tumor-bearing mice using positron emission tomography and computed tomography (PET/CT). Platelet labeling with RIS-GNPs did not alter the platelet functions, such as cellular proliferation and aggregation. PET/CT imaging clearly revealed the migration of platelets into tumor sites at 1 to 5 h post-transfer of RIS-GNP-labeled platelets, which was consistent with the biodistribution data. Our findings suggest that the imaging approach using RIS-GNPs makes it feasible to visualize the biological behavior of platelets in living organisms with cancer. Lee, Sang Bong; Ji, Hyun Dong; Lee, In-Kyu; Kim, Kil Soo; Lee, Jaetae; Lee, Sang-Woo; Jeon, Yong Hyun Gyeongbuk Inst Bio Ind, Vaccine Commercializat Ctr, 88 Saneopdanji Gil, Andong Si 33618, Gyeongbuk, South Korea; Korea Inst Med Microrobot KTMIRo, Gwangju 61011, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discover & Dev Diabet &, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea Kim, Seung/N-5248-2019; Lee, In-Kyu/AAR-6374-2021; Jeon, Yong/N-6910-2019; Lee, Sang/I-8954-2014; lee, sangwoo/KUD-1906-2024 57190304501; 57191592819; 36071537600; 35272034300; 7601451907; 57196249819; 16042453400 swleenm@knu.ac.kr;jeon9014@gmail.com; JOURNAL OF MATERIALS CHEMISTRY B J MATER CHEM B 2050-750X 2050-7518 9 12 SCIE MATERIALS SCIENCE, BIOMATERIALS 2021 7.571 21.1 0.12 2025-07-30 4 3 Animals; Biomarkers, Tumor; Biosensing Techniques; Blood Platelets; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Contrast Media; Gold; Humans; Iodine Radioisotopes; Kinetics; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Positron Emission Tomography Computed Tomography; Tissue Distribution; Cell proliferation; Computerized tomography; Diseases; Interlocking signals; Mammals; Nanoprobes; Nuclear medicine; Positron emission tomography; Tumors; contrast medium; gold; metal nanoparticle; radioactive iodine; tumor marker; Biodistributions; Biological behavior; Cardio-vascular disease; Cellular proliferations; Gold nanoprobe; Living organisms; Nuclear medicine imaging; Platelet labeling; animal; Bagg albino mouse; breast tumor; cell motion; cell proliferation; chemistry; experimental neoplasm; genetic procedures; human; isolation and purification; kinetics; metabolism; mouse; positron emission tomography-computed tomography; thrombocyte; tissue distribution; tumor cell line; Platelets English 2021 2021-03-28 10.1039/d0tb02265a 바로가기 바로가기 바로가기 바로가기
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Publication Year 논문이 출판된 연도입니다.
Publication Date 논문의 정확한 출판 날짜입니다 (년-월-일 형식).
DOI Digital Object Identifier. 디지털 객체 식별자로, 논문을 고유하게 식별하는 영구적인 식별번호입니다. 이를 통해 논문의 온라인 위치를 찾을 수 있습니다.