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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Machine Learning-Based Channel Prediction in Wideband Massive MIMO Systems With Small Overhead for Online Training | Channel prediction compensates for outdated channel state information in multiple-input multiple-output (MIMO) systems. Machine learning (ML) techniques have recently been implemented to design channel predictors by leveraging the temporal correlation of wireless channels. However, most ML-based channel prediction techniques have only considered offline training when generating channel predictors, which can result in poor performance when encountering channel environments different from the ones they were trained on. To ensure prediction performance in varying channel conditions, we propose an online re-training framework that trains the channel predictor from scratch to effectively capture and respond to changes in the wireless environment. The training time includes data collection time and neural network training time, and should be minimized for practical channel predictors. To reduce the training time, especially data collection time, we propose a novel ML-based channel prediction technique called aggregated learning (AL) approach for wideband massive MIMO systems. In the proposed AL approach, the training data can be split and aggregated either in an array domain or frequency domain, which are the channel domains of MIMO-OFDM systems. This processing can significantly reduce the time for data collection. Our numerical results show that the AL approach even improves channel prediction performance in various scenarios with small training time overhead. | Ko, Beomsoo; Kim, Hwanjin; Kim, Minje; Choi, Junil | Korea Adv Inst Sci & Technol, Sch Elect Engn, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | ; Choi, Junil/J-9156-2017; Ko, Beomsoo/KFB-4436-2024; Kim, Hwanjin/AAM-1813-2021; Kim, Minje/IWU-7197-2023 | 57414793300; 57204105066; 58930082700; 58298267400 | junil@kaist.ac.kr; | IEEE OPEN JOURNAL OF THE COMMUNICATIONS SOCIETY | IEEE OPEN J COMM SOC | 2644-125X | 5 | ESCI | ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2024 | 6.1 | 12.7 | 0 | 2025-05-07 | 0 | 0 | Training; Arrays; Training data; Data collection; Correlation; Channel estimation; Frequency-domain analysis; Channel prediction; wideband system; massive MIMO; machine learning; online re-training; training time overhead | NEURAL-NETWORKS; WIRELESS | Channel prediction; machine learning; massive MIMO; online re-training; training time overhead; wideband system | Frequency estimation; Array; Channel prediction; Correlation; Data collection; Frequency-domain analysis; Machine-learning; Massive multiple-input multiple-output; Multiple inputs; Multiple outputs; Online re-training; Training data; Training time; Training time overhead; Wideband systems; Channel estimation | English | 2024 | 2024 | 10.1109/ojcoms.2024.3449341 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Enhancing sustainable and climate-resilient agriculture: Optimization of greenhouse energy consumption through microgrid systems utilizing advanced meta-heuristic algorithms | Greenhouses offer controlled microclimates that enable year-round cultivation, improving food security and agricultural productivity. However, greenhouses are energy-intensive, with heating accounting for a significant portion of the associated costs. This study explores optimal microgrid configurations, economic viability, and policy recommendations for sustainable greenhouse agriculture in Nigeria. An in-depth energy assessment of a reference greenhouse in a South Korean facility is conducted. Distinct climatic differences between South Korea and Nigeria are highlighted, emphasizing the need for tailored greenhouse designs and energy solutions. Shifting focus to Nigeria, this study investigates the feasibility of hybrid renewable energy systems with a focus on wind and solar power across six geopolitical zones in Nigeria. The analysis encompasses technical, economic, and policy aspects, providing a holistic perspective on renewable energy adoption. Notably, the study uses an advanced optimization model, Teaching and Learning -Based Optimization algorithm, to assess the net present cost and baseload supply reliability, offering valuable insights for investors and policymakers. The result indicates diverse energy requirements across Nigeria, with total monthly peak energy demands ranging from 5374.80 kWh in the Southeast to 17,115.76 kWh in the Northwest, and a notable variation in the Levelized Cost of Electricity (LCOE), with the lowest at $0.07327 in Kano. Specifically, in Ogun, the net present cost for the WTPV-ESS system stood at $520,935.45, while the PV-ESS system cost was substantially lower at $500,444.41. This confirms the effectiveness of location-specific analysis and shows the suitability of photovoltaic -battery energy storage systems for Nigeria 's diverse regions, with unique considerations for specific areas. Policy recommendations, including feed-in tariffs, renewable portfolio standards, net metering, research support, and market development, provide a holistic framework for the adoption of renewable energy and sustainable agriculture. Improving infrastructure, market access, and financing for smallholder farmers is integral for improving food security and standards of living in rural Nigeria. In conclusion, Nigeria can leverage renewable resources to revolutionize its energy and agriculture sectors, setting an example for a sustainable and resilient future. | Yakub, Abdulfatai Olatunji; Adesanya, Misbaudeen Aderemi; Same, Noel Ngando; Rabiu, Anis; Chaulagain, Deepak; Ogunlowo, Qazeem Opeyemi; Owolabi, Abdulhameed Babatunde; Park, Jaebum; Lim, Jeong-Ok; Lee, Hyun-Woo; Huh, Jeung-Soo | Kyungpook Natl Univ, Dept Convergence & Fus Syst Engn, Sangju 37224, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Agr Civil Engn, Daegu 41566, South Korea; Univ Prince Edward Isl, Fac Sustainable Design Engn FSDE, Future Urban & Energy Lab Sustainabil, Charlottetown, PE, Canada; Kyungpook Natl Univ, Dept Energy Convergence & Climate Change, Daegu 41566, South Korea; Fed Coll Agr Ibadan, Dept Agr & Bioenvironm Engn, PMB 5029, Ibadan, Nigeria; Kyungpook Natl Univ, Reg Leading Res Ctr Smart Energy Syst, Sangju 37224, South Korea; Kyungpook Natl Univ, Smart Agr Innovat Ctr, Daegu 41566, South Korea | OGUNLOWO, QAZEEM/ABB-5386-2021; Adesanya, Misbaudeen/AAA-4664-2022; RABIU, Anis/JXO-1947-2024 | 57894905100; 57264527200; 57895613600; 57264527100; 57208742538; 57265471800; 57192210107; 57237034300; 7403454245; 57209160180; 7102258915 | Yakubabdulfatai1@gmail.com;misbauadesanya@gmail.com;Samenoel1@gmail.com;rabiuanis@gmail.com;chaulagaindeepu11@gmail.com;ogunlowoqazeem@knu.ac.kr;owolabiabdulhameed@gmail.com;woqja133@naver.com;jolim@knu.ac.kr;whlee@knu.ac.kr;jshuh@knu.ac.kr; | ENERGY STRATEGY REVIEWS | ENERGY STRATEG REV | 2211-467X | 2211-4688 | 54 | SCIE | ENERGY & FUELS | 2024 | 9.9 | 12.9 | 0.6 | 2025-05-07 | 3 | 3 | Greenhouse; Sustainability; Renewable energy system; Climate-resilient; Metaheuristic algorithm | THERMAL-ENERGY; PERFORMANCE; HEAT; AIR; PV | Climate-resilient; Greenhouse; Metaheuristic algorithm; Renewable energy system; Sustainability | Commerce; Costs; Cultivation; Electric energy storage; Energy utilization; Food supply; Heuristic algorithms; Investments; Optimization; Solar energy; Climate-resilient; Energy systems; Food security; Meta-heuristics algorithms; Net present cost; Nigeria; Optimisations; Policy recommendations; Renewable energies; Renewable energy system; Greenhouses | English | 2024 | 2024-07 | 10.1016/j.esr.2024.101440 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Bacteriophage-assisted lysis and eluted genomic DNA-based detection of pathogenic bacterial contamination in food | Foodborne diseases represent a significant global health concern, with a substantial number of illnesses and fatalities reported annually owing to the consumption of contaminated food. Current methods for identifying foodborne pathogens cannot effectively distinguish live from dead bacteria or efficiently detect multiple targets. Therefore, we developed a selective detection method for three pathogenic bacteria in food samples that leverages bacteriophage-assisted live -cell lysis and exposed genomic DNA amplification. The antimicrobial activity and host specificity of these three bacteriophages were employed to confirm the target bacteria selectivity. Bacterial DNA purification using bacteriophage-assisted lysis demonstrated the superior activity of the selected phages in extracting DNA from Escherichia coli O157:H7 and Salmonella Typhimurium. The results from reactions involving the three strains, including Bacillus cereus, highlighted that a 1 h incubation period yielded the most efficient DNA extraction and purification. The polymerase chain reaction (PCR) products obtained were comparable in terms of concentration and purity with those generated using bacterial DNA prepared using a commercial kit. In the practical food sample application experiment, bacterial strains were successfully recovered and concentrated using a polyethersulfone filter, resulting in a concentration factor >3 for all samples. Furthermore, the concentration of purified bacterial DNA from contaminated kimchi cabbage exceeded 10 ng/ mu L. Notably, we could detect E. coli O157:H7, S. Typhimurium, and B. cereus spiked at 103 colony -forming units/ mL using multiplex PCR. This innovative bacteriophage-based approach holds substantial promise for the selective and practical detection of live foodborne pathogens, thereby significantly advancing food safety standards. | Kim, Se -Min; Kim, Eo-Jin; Jang, Eun-Jin; Kim, Tai -Yong; Park, Hye-Min; Woo, Min-Ah; Lim, Min-Cheol; Lim, Jeong-A | Korea Food Res Inst KFRI, Res Grp Food Safety & Distribut, Wonju 55365, Jeollabuk Do, South Korea; Jeonbuk Natl Univ, Dept Food Sci & Technol, Jeonju Si 54896, Jeollabuk Do, South Korea; Chung Ang Univ, Dept Food Sci & Technol, Anseong 17546, Gyeonggi Do, South Korea; Dankook Univ, Dept Food Sci & Technol, Cheonan Si 31116, Chungcheongnam, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu Si 41566, South Korea; Korea Univ Sci & Technol, Dept Food Biotechnol, Daejeon Si 34113, South Korea | Kim, Yong Joon/IQS-7291-2023; Kim, Tae/AAV-5521-2020; Kim, Se Min/ABE-6534-2021 | 58415761700; 58943026800; 58943531300; 57200574406; 58943284900; 17347277400; 57193486887; 36437202400 | mclim@kfri.re.kr;jeongalim@kfri.re.kr; | FOOD CONTROL | FOOD CONTROL | 0956-7135 | 1873-7129 | 162 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2024 | 6.3 | 13.0 | 1.15 | 2025-05-07 | 4 | 4 | Foodborne bacteria; Bacteriophage; DNA purification; Multiplex PCR; Nucleic acid -based detection | REAL-TIME PCR; PROPIDIUM MONOAZIDE; SALMONELLA; ASSAYS | Bacteriophage; DNA purification; Foodborne bacteria; Multiplex PCR; Nucleic acid-based detection | English | 2024 | 2024-08 | 10.1016/j.foodcont.2024.110433 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | CRISPR/Cas9-mediated genome editing of OsCS511 enhances cold tolerance in Oryza sativa L. | The frequency of climate change is increasing globally, which makes predictions challenging. Cold spells during the rice seedling stage can significantly reduce yield, prompting a constant need for cold-tolerant cultivars, which is a major breeding goal. However, the traditional crossbreeding of rice cultivars requires substantial time and effort. Recently, the application of CRISPR/Cas9 to reduce defects in elite cultivars has become a more costeffective and time-efficient method for breeding cultivars than cross-breeding methods and can alleviate food insecurity. In the present study, CRISPR/Cas9-mediated genome editing was performed for OsCS511 a gene involved in cold susceptibility, identified using quantitative trait loci (QTL) mapping in Ilmi ( Oryza sativa L. spp. Japonica cv. Ilmi). In Ilmi, CRISPR/Cas9 tool-edited OsCS511 homozygous lines were used in T0 0 and advanced generations in the field. CRISPR/Cas9 induced variations in the DNA sequence and plants with insertions or deletions compared to OsCS511 of Ilmi were selected as genome-edited lines. Agricultural traits, reactive oxygen species scavenging capacity, and stress-tolerance-related gene expression levels were evaluated under normal and cold stress conditions. Under normal conditions, all traits evaluated in the Ilmi and OsCS511 genome-edited lines exhibited similar results; however, when subjected to cold stress, the cold tolerance of OsCS511 genomeedited lines improved or reached the same level as that of Ilmi. OsCS511 genome-edited lines recovered and survived. From a breeding perspective, we suggest that CRISPR/Cas9 technology can precisely reduce defects in existing superior rice cultivars with high efficiency and speed. | Park, Jae-Ryoung; Kim, Eun-Gyeong; Jang, Yoon-Hee; Jan, Rahmatullah; Farooq, Muhammad; Asif, Saleem; Zhao, Dan-Dan; Du, Xiao-Xuan; Lee, Gang-Seob; Kim, Kyung-Min | Rural Dev Adm, Natl Inst Crop Sci, Crop Breeding Div, Wonju 55365, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea; Rural Dev Adm, Natl Inst Agr Sci, Natl Agrobiodivers Ctr, Jeonju 54874, South Korea; RDA, Natl Inst Agr Sci, Gene Engn Div, Jeonju 54874, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Rural Dev Adm, Natl Inst Crop Sci, Crop Fdn Res Div, Wonju 55365, South Korea; Jeonbuk Natl Univ, Coll Agr & Life Sci, Dept Agr Biol, Jeonju, South Korea; Yancheng Inst Technol, Coll Marine & Bioengn, 211 Jianjun East Rd, Yancheng 224051, Jiangsu, Peoples R China | Kim, Kyung-Min Kim/C-7007-2014; Du, Xiaoxuan/AGZ-8638-2022; ZHAO, DANDAN/HIK-2130-2022; Jan, Rahmatullah/LFU-1421-2024 | 57211205505; 57221496070; 57219901992; 57201981969; 57209098077; 25927158200; 59820400400; 57396413700; 34868260300; 57459517300; 57215544380 | icd0192@korea.kr;keg950@korea.kr;uni315@korea.kr;rehmatbot@yahoo.com;mfarooqsr@gmail.com;saleemasif10@gmail.com;zhaodandan@korea.kr;haobingshuaike@hotmail.com;kangslee0227@gmail.com;kkm@knu.ac.kr; | ENVIRONMENTAL AND EXPERIMENTAL BOTANY | ENVIRON EXP BOT | 0098-8472 | 1873-7307 | 226 | SCIE | ENVIRONMENTAL SCIENCES;PLANT SCIENCES | 2024 | 4.7 | 13.0 | 1.86 | 2025-05-07 | 3 | 3 | CRISPR/Cas9; Cold stress; Rice; Breeding; Reactive oxygen species | CELL-WALL; CHILLING TOLERANCE; HYDROGEN-PEROXIDE; DROUGHT TOLERANCE; ABIOTIC STRESS; RICE; GENE; RESPONSES; YIELD; OVEREXPRESSION | Breeding; Cold stress; CRISPR/Cas9; Reactive oxygen species; Rice | climate change; cold tolerance; gene expression; genome; reactive oxygen species | English | 2024 | 2024-10 | 10.1016/j.envexpbot.2024.105932 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Letter | EDA-A2 increases lipid production in EDA2R-expressing human sebocytes | Kwack, Mi Hee; Hamida, Ons Ben; Lee, Weon Ju; Kim, Moon Kyu | Kyungpook Natl Univ, Sch Med, Dept Immunol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, FOUR KNU Convergence Educ Program Biomed Sci Creat, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Dermatol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Hair Transplantat Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 6507685557; 57899028800; 24474659000; 57199748390 | go3004@knu.ac.kr; | JOURNAL OF DERMATOLOGICAL SCIENCE | J DERMATOL SCI | 0923-1811 | 1873-569X | 113 | 1 | SCIE | DERMATOLOGY | 2024 | 4 | 13.0 | 0 | 2025-05-07 | 0 | 0 | ECTODYSPLASIN; EXPRESSION | acyl coenzyme A desaturase; cholesterol ester; diacylglycerol; ectodysplasin A1; ectodysplasin A2; fat droplet; lipid; liver X receptor alpha; membrane protein; peroxisome proliferator activated receptor gamma; phosphatidylcholine; phosphatidylserine; resistin; small interfering RNA; sterol regulatory element binding protein; sterol regulatory element binding protein 1a; sterol regulatory element binding protein 1c; triacylglycerol; unclassified drug; upstream stimulatory factor 1; XEDAR receptor; lipid; acne; adult; animal experiment; animal model; animal tissue; cell function; controlled study; EDA2R gene; gene expression; hair follicle; human; human cell; human tissue; in vivo study; keratinocyte; Letter; lipidomics; lipogenesis; male; mouse; nonhuman; papillary dermis; pathogenesis; Propionibacterium acnes; protein expression; sebaceous cell; sebaceous gland; signal transduction; upregulation; acne vulgaris; letter | English | 2024 | 2024-01 | 10.1016/j.jdermsci.2023.11.005 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Extracranial Vascular Malformations Increase Cardiovascular Disease Risk: A Nationwide Population-Based Cohort Study | Background:Extracranial vascular malformations affect vessel inflammation, clotting, and ischemia. However, the relationship between extracranial vascular malformations and myocardial infarction (MI) or stroke has not been fully elucidated. Limited studies have investigated the association between extracranial vascular malformations and cardiovascular diseases.Methods:A total of 48,701 patients with extracranial vascular malformations and a control cohort of 487,010 age- and sex-matched participants from the Korean National Health Insurance database were included. The incidence and risk of MI, ischemic stroke (IS), and hemorrhagic stroke (HS) between participants with extracranial vascular malformations and the control cohort was compared.Results:After adjusting for other cardiovascular disease risk factors, the adjusted hazard ratios (aHRs) for venous malformations, capillary malformations (CMs), arteriovenous malformations (AVMs), and lymphatic malformations in patients with acute MI were 1.25 (CI, 1.04 to 1.50), 1.41 (CI, 1.24 to 1.61), 1.68 (CI, 1.18 to 2.37), and 1.40 (CI, 1.31 to 1.48), respectively. For IS, the aHRs were 1.55 (CI, 1.35 to 1.77), 1.92 (CI, 1.74 to 2.11), 1.13 (CI, 0.78 to 1.64), and 1.51 (CI, 1.44 to 1.58), respectively. For HS, the aHRs were 1.51 (CI, 1.12 to 2.05), 5.63 (CI, 4.97 to 6.38), 2.93 (CI, 1.82 to 4.72), and 1.34 (CI, 1.20 to 1.50), respectively.Conclusions:Independent of cardiovascular risk factors, extracranial vascular malformations were associated with an increased risk of MI, IS, and HS. For patients with CMs and AVMs, intracerebral hemorrhage risk was particularly high, accounting for 563% and 293%, respectively. Therefore, even in patients with extracranial CMs or AVMs, performing diagnostic evaluations for cerebral AVMs and using measures to prevent intracerebral hemorrhage are crucial.CLINICAL QUESTION/LEVEL OF EVIDENCE:Risk, II. | Ryu, Jeong Yeop; Chang, Yong June; Lee, Joon Seok; Choi, Kang Young; Yang, Jung Dug; Lee, Seok-Jong; Lee, Jongmin; Huh, Seung; Kim, Ji Yoon; Chung, Ho Yun | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 680 Gukchaebosanro, Daegu 41405, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu, South Korea | Ryu, Jeong Yeop/GLQ-9419-2022; Yang, Jung/R-7806-2019; Lee, Joong/A-5417-2013 | 56366349400; 57949685900; 59349262100; 57203745682; 55171704700; 56013454400; 55689919700; 7101832929; 57205408095; 7404007181 | chunghoyun@gmail.com; | PLASTIC AND RECONSTRUCTIVE SURGERY | PLAST RECONSTR SURG | 0032-1052 | 1529-4242 | 154 | 5 | SCIE | SURGERY | 2024 | 3.4 | 13.0 | 2.11 | 2025-05-07 | 2 | 2 | PIK3CA CAUSE; MUTATIONS; TIE2 | Adult; Aged; Cardiovascular Diseases; Case-Control Studies; Cohort Studies; Female; Humans; Incidence; Ischemic Stroke; Male; Middle Aged; Myocardial Infarction; Republic of Korea; Risk Assessment; Risk Factors; Vascular Malformations; Young Adult; adult; aged; cardiovascular disease; case control study; cohort analysis; complication; congenital blood vessel malformation; epidemiology; etiology; female; heart infarction; human; incidence; ischemic stroke; male; middle aged; procedures; risk assessment; risk factor; South Korea; young adult | English | 2024 | 2024-11 | 10.1097/prs.0000000000011297 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Feasibility study of progressive Latin hypercube sampling and quasi-Monte Carlo simulation for probabilistic risk assessment | In probabilistic risk assessment (PRA), two main methods exist for quantifying fault trees: theoretical and empirical (sampling). The efficiency of PRA quantification varies depending on the sampling method used. This study evaluated the feasibility of using quasi-Monte Carlo simulation (Quasi-MCS) and progressive Latin hypercube sampling (P-LHS) for PRA quantification. Eight risk outcomes were derived through PRA for internal and external events in four cases. The PRA convergence, variability, and error rates of each sampling method were compared and analyzed. The comparison analysis revealed that all sampling methods had an error rate of approximately 2% with 9,000 total samples. P-LHS exhibited the best convergence and variability among the methods, followed by Quasi-MCS and LHS. Although Quasi-MCS showed more significant variability than LHS as the number of events increased, its error rate remained within 2% with 9,000 samples. Therefore, both P-LHS and Quasi-MCS are feasible for PRA quantification. | Jin, Seung-Seop; Kim, Gungyu; Kwag, Shinyoung; Eem, Seunghyun | Sejong Univ, Dept Civil & Environm Engn, Seoul, South Korea; Kyungpook Natl Univ, Dept Convergence & Fus Syst Engn, Daegu, South Korea; Hanbat Natl Univ, Dept Civil & Environm Engn, Daejeon, South Korea; Kyungpook Natl Univ, Dept Convergence & Fus Syst Engn, Major Plant Syst Engn, Daegu, South Korea | ; Eem, Seunghyun/KVB-1493-2024; Jin, SeungSeop/KYR-3451-2024 | 57207929857; 58487834500; 55779491500; 52363442900 | skwag@hanbat.ac.kr;eemsh@knu.ac.kr; | GEOMATICS NATURAL HAZARDS & RISK | GEOMAT NAT HAZ RISK | 1947-5705 | 1947-5713 | 15 | 1 | SCIE | GEOSCIENCES, MULTIDISCIPLINARY;METEOROLOGY & ATMOSPHERIC SCIENCES;REMOTE SENSING;WATER RESOURCES | 2024 | 4.6 | 13.0 | 0 | 2025-05-07 | 0 | 0 | Probabilistic risk assessment (PRA); safety assessment; progressive Latin hypercube sampling (P-LHS); Quasi-Monte Carlo Simulation (Quasi-MCS); risk quantification | Probabilistic risk assessment (PRA); progressive Latin hypercube sampling (P-LHS); Quasi-Monte Carlo Simulation (Quasi-MCS); risk quantification; safety assessment | Digital elevation model; Error statistics; Fault tree analysis; Monte Carlo methods; Risk assessment; Error rate; Latin hypercube sampling; Probabilistic risk assessment; Progressive latin hypercube sampling; Quasi-monte carlo simulation; Risk quantification; Safety assessments; Sampling method | English | 2024 | 2024-12-31 | 10.1080/19475705.2024.2425185 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Indications for Furlow Double-Opposing Z-Plasty in Patients with Velopharyngeal Insufficiency following 2-Flap Palatoplasty | Background: Various surgical methods have been developed for treating velopharyngeal insufficiency (VPI); however, the choice of surgical treatment is controversial. The pharyngeal flap, which is commonly used, has a high success rate but frequently leads to airway complications. Furlow double-opposing Z-plasty (DOZ) does not deform the velopharyngeal port; therefore, it is expected to show good speech outcomes while reducing airway complications if an appropriate indication is noted. This study aimed to identify indications for DOZ in cases of VPI after palatoplasty. Methods: Nonsyndromic patients who underwent palatoplasty were prospectively followed from 2008 to 2016, and those diagnosed with VPI were treated with DOZ. Preoperative facial computed tomography (CT) and postoperative nasometric assessment results were examined. Surgical indication was set based on a 30% threshold value for postoperative nasalance. Results: Comparing the preoperative CT measurements of both groups, high need ratio (NR), wide width of the nasopharynx (WNP), and long velopharyngeal depth (VPD) were contributing factors to VPI occurrence (P < 0.05). Analyzing preoperative CT and postoperative speech evaluation results, a linear relationship was observed between preoperative NR, WNP, and VPD and postoperative nasalance. In cases where NR was less than 0.81, WNP was less than 27.64 mm, and VPD was less than 20.34 mm, DOZ showed favorable outcomes (P < 0.05). Conclusions: Preoperative CT evaluation should be performed in patients with VPI. When WNP, VPD, and NR values are small, DOZ can achieve sufficient correction of VPI and reduce the risk of airway complications. In cases where the indication range is exceeded, the pharyngeal flap is considered. | Park, Tae Hyun; Kang, Hyun Su; Ryu, Jeong Yeop; Lee, Joon Seok; Yang, Jung Dug; Chung, Ho Yun; Choi, Kang Young | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 130 Dongdeok Ro, Daegu 41944, South Korea | Yang, Jung/R-7806-2019; Ryu, Jeong Yeop/GLQ-9419-2022 | 57223690181; 58890125800; 56366349400; 59349262100; 55171704700; 7404007181; 57203745682 | kychoi@knu.ac.kr; | PLASTIC AND RECONSTRUCTIVE SURGERY | PLAST RECONSTR SURG | 0032-1052 | 1529-4242 | 154 | 5 | SCIE | SURGERY | 2024 | 3.4 | 13.0 | 1.06 | 2025-05-07 | 1 | 1 | CLEFT-PALATE REPAIR; PHARYNGEAL FLAP SURGERY; SPHINCTER PHARYNGOPLASTY; SURGICAL-CORRECTION; PERCEPTUAL SPEECH; NASOMETRIC VALUES; NASAL RESONANCE; DYSFUNCTION; MANAGEMENT; CHILDREN | Adolescent; Child; Child, Preschool; Cleft Palate; Female; Humans; Male; Palate, Soft; Plastic Surgery Procedures; Postoperative Complications; Prospective Studies; Surgical Flaps; Tomography, X-Ray Computed; Treatment Outcome; Velopharyngeal Insufficiency; adolescent; adverse event; child; cleft palate; etiology; female; human; male; palatopharyngeal incompetence; plastic surgery; postoperative complication; preschool child; procedures; prospective study; soft palate; surgery; surgical flaps; treatment outcome; x-ray computed tomography | English | 2024 | 2024-11 | 10.1097/prs.0000000000011253 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Polarimetric Retrieval of Raindrop Size Distribution: Double-Moment Normalization Approach and Machine Learning Techniques | Retrieving raindrop size distribution (DSD) is essential to understanding precipitation processes. Conventional approaches based on polarimetric radar (e.g., polynomial regression) struggle to accurately capture the inherent nonlinearity between DSD parameters and radar measurables. In contrast, machine learning (ML) algorithms offer a promising solution as it effectively models the complex non-linear relationship. We have developed an ML algorithm to retrieve DSD parameters using polarimetric radar variables in a framework of double-moment normalization. The potentially stable and invariant double-moment normalized DSD enables the applicability of the algorithm in any climatic regime or any precipitation system. To improve the robustness of the model to measurement noises, we employed training samples with random noise. All ML algorithms outperformed the conventional method, with the random forest being the best model. This study highlights the effectiveness of the developed algorithm as a tool for understanding the DSD characteristics from polarimetric radar measurements. Raindrop size distribution (DSD) is an essential component of precipitation characteristics. DSD is often represented by a particular mathematical functional form which is composed of a few parameters. Retrieving the parameters from radar measurements can assist in identifying the microphysics of precipitation systems at high spatiotemporal resolution. This study developed a machine learning algorithm to retrieve parameters of double-moment normalized DSD, which offers advantages over the other DSD forms thanks to two characteristic parameters and potentially universal normalized DSD shape. This study also demonstrates the practical application of the trained model by retrieving DSD information from real radar measurements. We present a machine learning algorithm for the retrieval of raindrop size distribution parameters based on polarimetric radar measurementThe retrieval is based on the double-moment normalization for potential universal applicationsThe suggested model was applied to the X-band polarimetric radar data and outperformed the conventional polynomial regression model | Shin, Kyuhee; Kim, Kwonil; Song, Joon Jin; Lee, Gyuwon | Kyungpook Natl Univ, Ctr Atmospher REmote Sensing CARE, Dept Atmospher Sci, Daegu, South Korea; SUNY Stony Brook, Sch Marine & Atmospher Sci, Stony Brook, NY USA; Baylor Univ, Dept Stat Sci, Waco, TX USA | ; Shin, Kyuhee/LMO-2829-2024; Kim, Kwonil/HTN-0103-2023 | 57222003871; 57191964318; 14062434200; 7404852271 | gyuwon@knu.ac.kr; | GEOPHYSICAL RESEARCH LETTERS | GEOPHYS RES LETT | 0094-8276 | 1944-8007 | 51 | 1 | SCIE | GEOSCIENCES, MULTIDISCIPLINARY | 2024 | 4.6 | 13.0 | 0 | 2025-05-07 | 2 | 2 | raindrop size distribution; machine learning; polarimetric radar | X-BAND; DIFFERENTIAL REFLECTIVITY; DISTRIBUTION PARAMETERS; RADAR REFLECTIVITY; VIDEO DISDROMETER; PART I; ATTENUATION; VARIABILITY; MODEL; SPECTRA | machine learning; polarimetric radar; raindrop size distribution | Drops; Forestry; Polarimeters; Radar measurement; Size distribution; Conventional approach; Machine learning algorithms; Machine learning techniques; Machine-learning; Moment normalization; Non-linear relationships; Polarimetric radars; Polynomial regression; Precipitation process; Raindrop size distribution; algorithm; machine learning; radar; raindrop; size distribution; Machine learning | English | 2024 | 2024-01-16 | 10.1029/2023gl106057 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Risk and Mortality of Cardiovascular Diseases in Patients with Dupuytren Disease: A Nationwide Population-Based Cohort Study | Background: Dupuytren disease (DD) is a type of fibroproliferative disease that involves the palmar aspect of the hand. Although many benign fibroproliferative diseases have been shown to increase the risk of cardiovascular disease, the relationship between DD and myocardial infarction (MI) or stroke has not been fully elucidated. Methods: A total of 35,909 patients with DD and a control cohort with 1,077,270 age- and sex-matched participants from the Korean National Health Insurance database were included. The incidences of MI, stroke, and survival after cardiovascular events, were compared between participants with DD and the control cohort. Results: Compared with the control cohort, the incidence rate ratios for cardiovascular diseases in DD were as follows: 1.51 (95% CI, 1.44 to 1.58) for MI; 2.01 (95% CI, 1.94 to 2.09) for ischemic stroke (IS); and 1.49 (95% CI, 1.36 to 1.63) for hemorrhagic stroke . After adjusting for other cardiovascular disease risk factors, DD was associated with an increased risk of IS. Based on the age-, sex-, and body mass index–stratified analyses, an increased risk of MI was identified in the younger age group (<50 years) and thin subjects (body mass index < 18.5 kg/m2). Adjusted hazard ratios for mortality in subjects with DD who developed cardiovascular diseases were 0.51 (95% CI, 0.43 to 0.60), 0.56 (95% CI, 0.50 to 0.62), and 1.08 (95% CI, 0.86 to 1.36), respectively. Conclusions: DD is associated with an increased risk of IS, independent of cardiovascular risk factors. DD is also associated with an increased risk of MI in individuals younger than 50 years. DD did not significantly aggravate mortality secondary to cardiovascular events. Copyright © 2024 by the American Society of Plastic Surgeons. | Ryu, Jeong Yeop; Park, Tae Hwan; Lee, Joon Seok; Choi, Kang Young; Yang, Jung Dug; Chung, Ho Yun | Department of Plastic and Reconstructive Surgery, Kyungpook National University, South Korea; Department of Plastic and Reconstructive Surgery, Kyungpook National University, South Korea; Department of Plastic and Reconstructive Surgery, Kyungpook National University, South Korea; Department of Plastic and Reconstructive Surgery, Kyungpook National University, South Korea; Department of Plastic and Reconstructive Surgery, Kyungpook National University, South Korea; Department of Plastic and Reconstructive Surgery, Kyungpook National University, South Korea, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, South Korea | 56366349400; 57200580172; 56496041000; 57203745682; 55171704700; 7404007181 | prsryu@knu.ac.kr; | Plastic and Reconstructive Surgery | PLAST RECONSTR SURG | 0032-1052 | 1529-4242 | 156 | 1 | SCIE | SURGERY | 2024 | 3.4 | 13.0 | 0 | 2025-05-07 | 0 | English | Final | 2025 | 10.1097/prs.0000000000011944 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | Article | Amidoxime-Containing Zr and Hf Atomic Layer Deposition Precursors for Metal Oxide Thin Films | In this article, we discuss the synthesis of eight novel zirconium and hafnium complexes containing amidoxime ligands as potential precursors for atomic layer deposition (ALD). Two amidoximes, viz., (E)-N′-hydroxy-N,N-dimethylacetimidamide (mdaoH) and (Z)-N′-hydroxy-N,N-dimethylpivalimidamide (tdaoH), along with their Zr and Hf homoleptic complexes, Zr(mdao)4 (1), Hf(mdao)4 (2), Zr(tdao)4 (3), and Hf(tdao)4 (4) were prepared. We further synthesized heteroleptic compounds with different physical properties by introducing cyclopentadienyl (Cp) ligand, namely, CpZr(mdao)3 (5), CpHf(mdao)3 (6), CpZr(tdao)3 (7), and CpHf(tdao)3 (8). Thermogravimetric analysis was used for the assessment of the evaporation characteristics of complexes 1, 2, 5, and 6, and it revealed multistep weight losses with high residues. On the other hand, the thermogravimetric analysis curves of complexes 3, 4, 7, and 8 comprising tdao ligands revealed single-step weight losses with moderate residues. Single-crystal X-ray diffraction studies of complexes 1, 3, and 7 showed that all of the complexes have monomeric molecular structures. Complex 7 exhibited a low melting point (75 °C), good volatility, and high thermal stability compared with other complexes. Therefore, an atomic layer deposition process for the growth of ZrO2 was developed by using ZrCp(tdao)3 (7) as a novel precursor. © 2023 American Chemical Society | Lee, Ga Yeon; Lee, Seung-Hun; Jo, In Ho; Cho, Chan-Mi; Shostak, Svetlana; Ryu, Ji Yeon; Park, Bo Keun; Son, Seung Uk; Choi, Cheol Ho; Eom, Taeyong; Kim, Jeong Hwan; Chung, Taek-Mo | Thin Film Materials Research Center, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Daejeon, 34114, South Korea; Department of Advanced Materials Engineering, Hanbat National University, Daejeon, 34158, South Korea; Department of Advanced Materials Engineering, Hanbat National University, Daejeon, 34158, South Korea; Thin Film Materials Research Center, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Daejeon, 34114, South Korea; Department of Chemistry, Kyungpook National University, Daegu, 41566, South Korea; Thin Film Materials Research Center, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Daejeon, 34114, South Korea; Thin Film Materials Research Center, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Daejeon, 34114, South Korea, Department of Chemical Convergence Materials, University of Science and Technology (UST), 217 Gajeong-ro, Daejeon, 34113, South Korea; Department of Chemistry, Sungkyunkwan University, 2066 Seobu-ro, Gyeonggi-do, Suwon-si, 16419, South Korea; Department of Chemistry, Kyungpook National University, Daegu, 41566, South Korea; Thin Film Materials Research Center, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Daejeon, 34114, South Korea; Department of Advanced Materials Engineering, Hanbat National University, Daejeon, 34158, South Korea; Thin Film Materials Research Center, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Daejeon, 34114, South Korea, Department of Chemical Convergence Materials, University of Science and Technology (UST), 217 Gajeong-ro, Daejeon, 34113, South Korea | 58222714300; 59628665700; 57551437700; 57556723800; 57210514532; 56074303900; 24174798200; 7202529923; 7402958948; 24080081500; 55966663900; 7401571389 | tmchung@krict.re.kr; | Inorganic Chemistry | INORG CHEM | 0020-1669 | 1520-510X | 63 | 1 | SCIE | CHEMISTRY, INORGANIC & NUCLEAR | 2024 | 4.7 | 13.1 | 0 | 2025-05-07 | 0 | Atoms; Chelation; Hafnium oxides; Ligands; Oxide films; Single crystals; Synthesis (chemical); Thermogravimetric analysis; Zirconia; hafnium; metal oxide; zirconium; Amidoxime; Atomic-layer deposition; Complex 1; Deposition precursors; Hafnium complexes; Homoleptic complex; Metal oxide thin films; Synthesised; Weight loss; Zirconium complexes; article; atomic layer deposition; body weight loss; chemical structure; drug analysis; drug development; evaporation; melting point; nonhuman; thermogravimetry; thermostability; volatilization; X ray diffraction; Atomic layer deposition | English | Final | 2024 | 10.1021/acs.inorgchem.3c03455 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Luminescent Cs8PbBr6 ⁴⁺ Quantum Dots Centered on the Octahedral PbBr6 ⁴⁻ Cluster within Zeolite LTA: Exploring the Edge of Three-Dimensional Crystal Structure and Its Stability | The perovskite quantum dots (QDs) of CsPbX3 (X = Cl, Br, I) exhibit exceptional photoluminescent properties, but their sensitivity to moisture and heat poses a challenge. This study presents a solvent-free synthesis approach for incorporating CsPbBr3 perovskite QDs into zeolite A. The introduction of [Cs8PbBr6](4+) perovskite QDs into the zeolite framework resulted in a highly stable configuration, maintaining its initial luminescence properties even after being underwater or exposed to heat. The structure is determined by 3-dimensional single-crystal crystallography. Each octahedral PbBr64- ion is surrounded by Cs+ ions and [Cs8PbBr6](4+) perovskite QDs being formed at the 32% of the center of a large cavity. Further, [Na12CsBr8](5+) QDs are formed at the very center of another 46% large cavities by combining Cs+, Na+, and Br- ions. The peak in the emission spectrum of Pb,Br,Cs,Na-A is similar to those of the CsPbBr3 nanocrystal, Cs4PbBr6 0-dimensional perovskite QDs, and Pb,Br,H,Cs,Na-FAU(X and Y). This work demonstrates that Pb,Br,Cs,Na-A can be produced using a simplified solvent-free synthesis procedure, which exhibits excellent stability against moisture and heat. Moreover, through a straightforward process, various quantum dots (QDs) can be incorporated into zeolite cavities to develop materials with variety photoluminescent properties. | Lim, Hyeon Seung; Jeong, Sang Gil; Park, Gi Beom; Kim, Joon Young; Heo, Nam Ho; Lim, Woo Taik | Kumoh Natl Inst Technol, Gumi 39177, South Korea; Kyungpook Natl Univ, Coll Engn, Dept Appl Chem, Daegu 41566, South Korea; Kyungbuk Coll, Coll Engn, Dept Fire Safety Management, Yeongju 36133, South Korea; Korea Inst Energy Technol, Hydrogen Energy Technol Lab, Naju 58330, South Korea; Andong Natl Univ, Coll Engn, Dept Chem & Biol Engn, Andong 36729, South Korea | 57189697532; 58563760000; 57205061558; 57280808300; 17136916900; 7202378245 | nhheo@knu.ac.kr;wtlim@anu.ac.kr; | INORGANIC CHEMISTRY | INORG CHEM | 0020-1669 | 1520-510X | 63 | 30 | SCIE | CHEMISTRY, INORGANIC & NUCLEAR | 2024 | 4.7 | 13.1 | 0 | 2025-05-07 | 0 | 0 | NANOCRYSTALS; CESIUM; CSPBX3; BRIGHT; BR; CL | Bromine compounds; Cesium compounds; Crystal structure; Emission spectroscopy; Ions; Luminescence; Moisture; Nanocrystals; Perovskite; Semiconductor quantum dots; Single crystals; Sodium compounds; Zeolites; cesium ion; nanocrystal; perovskite; quantum dot; solvent; zeolite; %moisture; Crystals structures; Cs +; Highly stables; Large cavities; Photo-luminescent properties; Solvent free synthesis; Three-dimensional crystals; Zeolite LTA; Zeolite-A; article; controlled study; crystal structure; crystallography; drug analysis; luminescence; moisture; pharmaceutics; synthesis; Lead compounds | English | 2024 | 2024-07-17 | 10.1021/acs.inorgchem.4c01473 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Anti-cancer effects of DHP107 on canine mammary gland cancer examined through in-vitro and in-vivo mouse xenograft models | BackgroundCanine mammary gland cancer (CMGC) is a common neoplasm in intact bitches. However, the benefit of adjuvant chemotherapy is unclear. The aim of this study was to investigate the anti-proliferative effects of paclitaxel on CMGC in in-vitro and in-vivo settings.ResultsPaclitaxel dose-dependently inhibited viability and induced G2/M phase cell cycle arrest and apoptosis in both primary and metastatic CMGC cell lines (CIPp and CIPm). In animal experiments, the average tumour volume decreased significantly in proportion to the administered oral paclitaxel dose. By examining tumour tissue using a TUNEL assay and immunohistochemical staining with anti-CD31 as a marker of endothelial differentiation, respectively, it was confirmed that oral paclitaxel induced apoptosis and exerted an anti-angiogenetic effect in tumour tissues. Further, downregulation of cyclin D1 in tumour tissues suggested that oral paclitaxel induced cell cycle arrest in tumour tissues in-vivo.ConclusionsOur results suggest that paclitaxel may have anti-cancer effects on CMGC through cell cycle arrest, induction of apoptosis, and anti-angiogenesis. This study could provide a novel approach to treat CMGC. | Chae, Hyung-Kyu; Oh, Ye-In; Lim, Ga-Hyun; Jung, Yun-Chan; Park, Seol-Hee; An, Ju-Hyun; Park, Su-Min; Seo, Kyoung-Won; Chu, Sung-Nam; Li, Qiang; Youn, Hwa-Young | Seoul Natl Univ, Coll Vet Med, Lab Vet Internal Med, Seoul 08826, South Korea; Western Referral Anim Med Ctr, Dept Vet Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daegu, South Korea; CHA Univ, Lab Anim Ctr, CHA Biocomplex, Sungnam, South Korea; Kangwon Natl Univ, Dept Vet Emergency & Crit Care Med, Coll Vet Med, Chuncheon Si, South Korea; Kangwon Natl Univ, Inst Vet Sci, Coll Vet Med, Chunchon, South Korea; DaeHwa Pharmaceut Co Ltd, Pangyo Res Lab, Sungnam, South Korea; YanBian Univ, Agr Coll, Dept Vet Med, Yanji 133000, Jilin, Peoples R China | Seo, Kwang/AAB-4821-2020 | 57194644489; 36466903200; 58132315300; 57193702712; 37075464300; 57206839650; 57211909684; 8833507700; 58791596500; 57192878065; 7102027331 | liqiang8589@ybu.edu.cn;hyyoun@snu.ac.kr; | BMC VETERINARY RESEARCH | BMC VET RES | 1746-6148 | 20 | 1 | SCIE | VETERINARY SCIENCES | 2024 | 2.6 | 13.2 | 0 | 2025-05-07 | 0 | 0 | Cancer; Chemotherapy; Canine; Oral paclitaxel; Mammary gland cancer | ORAL PACLITAXEL FORMULATION; ADVANCED SOLID TUMORS; BREAST-CANCER; DOGS; CHEMOTHERAPY; EFFICACY; THERAPY | Cancer; Canine; Chemotherapy; Mammary gland cancer; Oral paclitaxel | Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dog Diseases; Dogs; Heterografts; Humans; Mammary Glands, Human; Mice; Neoplasms; Paclitaxel; Rodent Diseases; cyclin D1; paclitaxel; platelet endothelial cell adhesion molecule 1; paclitaxel; adjuvant chemotherapy; animal cell; animal experiment; animal model; animal tissue; antiangiogenic activity; antineoplastic activity; apoptosis; Article; bitch; breast cancer; breast cancer cell line; Canis; cell cycle assay; cell proliferation assay; cell viability; CIPm cell line; CIPp cell line; controlled study; DNA fragmentation assay; down regulation; drug efficacy; drug toxicity; female; flow cytometry; fluorescence activated cell sorting; G2 phase cell cycle checkpoint; gastrointestinal tissue; histopathology; immunohistochemistry; in vitro study; in vivo study; mammary gland; mouse; nonhuman; nude mouse; randomized controlled trial; tumor growth; tumor volume; TUNEL assay; Western blotting; xenograft; animal; cell cycle checkpoint; cell proliferation; dog; dog disease; human; mammary gland; neoplasm; rodent disease; tumor cell line; veterinary medicine; xenograft | English | 2024 | 2024-01-03 | 10.1186/s12917-023-03837-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Assessment of MMP-9 and clinical characteristics in dogs with tracheal collapse based on cough severity and fluoroscopic findings: a cross-sectional study | BackgroundTracheal collapse (TC), a common disease in dogs, is characterized by cough; however, little is known about the serum biomarkers that can objectively evaluate the severity of cough in canine TC. Furthermore, studies elucidating the relationship of fluoroscopic characteristics with the severity of cough are lacking. Therefore, this study aimed to evaluate the relationship between cough severity and clinical characteristics, fluoroscopic images, and new serum biomarkers in canine TC.ResultsFifty-one client-owned dogs diagnosed with TC based on fluoroscopic and clinical signs were enrolled in this study and divided into three groups according to the severity of cough (grade of cough: 0, 1, and 2). Signalments, comorbidities, and fluoroscopic characteristics were compared among the groups retrospectively. The serum matrix metalloproteinase-9 (MMP-9), interleukin-6 (IL-6), surfactant protein-A (SP-A), and syndecan-1 (SDC-1) levels were measured in all groups. No significant differences in age, breed, sex, or clinical history were observed among the groups. Concomitant pharyngeal collapse increased significantly with the severity of cough (p = .031). Based on the fluoroscopic characteristics, the TC grade of the carinal region increased significantly and consistently with the grade of cough (p = .03). The serum MMP-9 level was significantly higher in the grade 2 group than that in the grade 0 group (p = .014). The serum IL-6 level was significantly lower in the grade 1 group than that in the grade 0 group (p = .020). The serum SP-A and SDC-1 levels did not differ significantly among the groups.ConclusionsThe severity of cough with the progression of TC can be predicted with the fluoroscopic TC grade at the carinal region. MMP-9 may be used as an objective serum biomarker that represents cough severity to understand the pathogenesis. | Jung, Da-Yeon; Park, Su-Min; Lim, Ga-Hyun; Seo, Kyoung-Won; Oh, Ye-In; Youn, Hwa-Young | Seoul Natl Univ, Coll Vet Med, Lab Vet Internal Med, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Vet Sci, Seoul 00826, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daegu 41566, South Korea | Seo, Kwang/AAB-4821-2020 | 58690486900; 57211909684; 58132315300; 8833507700; 36466903200; 7102027331 | imyein5@knu.ac.kr;hyyoun@snu.ac.kr; | BMC VETERINARY RESEARCH | BMC VET RES | 1746-6148 | 20 | 1 | SCIE | VETERINARY SCIENCES | 2024 | 2.6 | 13.2 | 1.24 | 2025-05-07 | 1 | 1 | Tracheal collapse; Tracheobronchomalacia; Fluoroscopy; Cough; MMP-9; IL-6; SP-A; SDC-1; Dog | AIRWAY COLLAPSE; LUNG-FUNCTION; BRONCHOMALACIA; SYNDECAN-1; BIOMARKERS; HERNIATION; EXPOSURE; ASTHMA | Cough; Dog; Fluoroscopy; IL-6; MMP-9; SDC-1; SP-A; Tracheal collapse; Tracheobronchomalacia | ademetionine; amoxicillin plus clavulanic acid; benazepril; biological marker; bromhexine; camostat; codeine; cyclosporine; doxycycline; enalapril; esomeprazole; famotidine; fluticasone; furosemide; gelatinase B; interleukin 6; leflunomide; levetiracetam; levothyroxine; liver protective agent; lypex; metoclopramide; montelukast; mycophenolate mofetil; omeprazole; phenobarbital; prednisolone; salbutamol; sildenafil; silymarin; spironolactone; stomach secretion inhibitor; surfactant protein A; syndecan 1; theophylline; torasemide; trilostane; unclassified drug; ursodeoxycholic acid; zentonil; zonisamide; animal experiment; Article; blood sampling; clinical characteristics; clinical evaluation; clinical feature; collapse; comorbidity; coughing; cross-sectional study; disease severity; dog; dog breed; enzyme linked immunosorbent assay; female; fluoroscopy; hernia; lung herniation; male; nebulization; nonhuman; retrospective study; tracheal collapse | English | 2024 | 2024-02-10 | 10.1186/s12917-023-03872-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Base/DMSO-Promoted Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines via C-C Bond Formation | In this study, a synthetic method to access benzo[4,5]imidazo[2,1-a]isoquinolines is developed by the reaction of 2-(2-bromoaryl)benzimidazoles with 1,3-diketones under basic conditions. A reaction pathway involving the initial formation of a C-C coupled intermediate by nucleophilic aromatic substitution and subsequent deacylative cyclocondensation is proposed for this process. | Lee, Seong Weon; Dao, Pham Duy Quang; Lim, Ho-Jin; Cho, Chan Sik | Kyungpook Natl Univ, Dept Appl Chem, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Elect Engn, 80 Daehakro, Daegu 41566, South Korea | ; Dao, P. D. Quang/AAR-9880-2021 | 57737643600; 57194217171; 56883100200; 7403100019 | cscho@knu.ac.kr; | ADVANCED SYNTHESIS & CATALYSIS | ADV SYNTH CATAL | 1615-4150 | 1615-4169 | 366 | 5 | SCIE | CHEMISTRY, APPLIED;CHEMISTRY, ORGANIC | 2024 | 4 | 13.2 | 0.61 | 2025-05-07 | 2 | 2 | N-Fused heterocycles; C-C Bond formation; Cyclization; Basic condition; Nucleophilic aromatic substitution | ONE-POT SYNTHESIS; H ACTIVATION; ARYL HALIDES; DERIVATIVES; BENZIMIDAZOLES; ISOQUINOLINES; CYCLIZATION; ANNULATION; ARYLATION | Basic condition; Cyclization; C−C Bond formation; N-Fused heterocycles; Nucleophilic aromatic substitution | English | 2024 | 2024-03-08 | 10.1002/adsc.202301365 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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