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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Identification of α-amanitin effector proteins in hepatocytes by limited proteolysis-coupled mass spectrometry | The misuse of poisonous mushrooms containing amatoxins causes acute liver failure (ALF) in patients and is a cause of significant mortality. Although the toxic mechanisms of alpha-amanitin (alpha-AMA) and its interactions with RNA polymerase II (RNAP II) have been studied, alpha-AMA effector proteins that can interact with alpha-AMA in hepatocytes have not been systematically studied. Limited proteolysis-coupled mass spectrometry (LiP-MS) is an advanced technology that can quickly identify protein-ligand interactions based on global comparative proteomics. This study identified the alpha-AMA effector proteins found in human hepatocytes, following the detection of conformotypic peptides using LiP-MS coupled with tandem mass tag (TMT) technology. Proteins that are classified into protein processing in the endoplasmic reticulum and the ribosome during the KEGG pathway can be identified through affinity evaluation, according to alpha-AMA concentration-dependent LiP-MS and LiP-MS in hepatocytes derived from humans and mice, respectively. The possibility of interaction between alpha-AMA and proteins containing conformotypic peptides was evaluated through molecular docking studies. The results of this study suggest a novel path for alpha-AMA to induce hepatotoxicity through interactions with various proteins involved in protein synthesis, as well as with RNAP II. | Kim, Doeun; Lee, Min Seo; Kim, Nam Doo; Lee, Sangkyu; Lee, Hye Suk | Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Catholic Univ Korea, Coll Pharm, BK21 sponsored Adv Program SmartPharma Leaders 4, Bucheon 14662, South Korea; Voronoibio Inc, Incheon 21984, South Korea; Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea; Catholic Univ Korea, Coll Pharm, Bucheon 14662, South Korea | 57219650718; 57225079010; 57212056577; 57209046767; 35316111800 | sangkyu@skku.edu;sianalee@catholic.ac.kr; | CHEMICO-BIOLOGICAL INTERACTIONS | CHEM-BIOL INTERACT | 0009-2797 | 1872-7786 | 386 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;PHARMACOLOGY & PHARMACY;TOXICOLOGY | 2023 | 4.7 | 14.6 | 0.49 | 2025-06-25 | 3 | 3 | Alpha-amanitin; Toxic mushroom; Limited proteolysis-coupled mass spectrometry; Acute liver failure; Spliceosome | COMPUTATIONAL PLATFORM; STRUCTURAL-CHANGES; TRIGGER LOOP; QUANTIFICATION; MECHANISMS | Acute liver failure; Alpha-amanitin; Limited proteolysis-coupled mass spectrometry; Spliceosome; Toxic mushroom | Alpha-Amanitin; Animals; Hepatocytes; Humans; Mass Spectrometry; Mice; Molecular Docking Simulation; Proteolysis; alpha amanitin; alpha tubulin; anazolene sodium; peptide; proteome; RNA polymerase II; acute liver failure; AML12 cell line; animal cell; Article; binding affinity; controlled study; endoplasmic reticulum; Huh-7 cell line; human; human cell; hydrophobicity; immunoblotting; KEGG; liver cell; liver toxicity; mass spectrometry; molecular docking; mushroom poisoning; nonhuman; protein degradation; protein interaction; protein synthesis; ribosome; spliceosome; TMT labeling; animal; mass spectrometry; metabolism; mouse; protein degradation | English | 2023 | 2023-12-01 | 10.1016/j.cbi.2023.110778 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Insights into the inhibitory activities of neolignans and diarylnonanoid derivatives from nutmeg (Myristica fragrans Houtt.) seeds on soluble epoxide hydrolase using in vitro and in silico approaches | Two new neolignans, myrifralignans F-G (14 and 18), four new diarylnonanoid derivatives, myrifragranones A-D (21-24), and 18 known compounds were isolated and structurally elucidated from nutmeg (Myristica fragrans Houtt.) seeds. The absolute configurations of these secondary metabolites were determined using the electronic circular dichroism technique. The inhibitory potential of these isolated compounds on soluble epoxide hydrolase (sEH) was investigated for the first time. Among them, malabaricones B and C (19 and 20) and four new compounds 21-24 displayed inhibitory activities against sEH, with IC50 values ranging from 14.24 to 46.35 mu M. Additionally, the binding mechanism, key binding interactions, stability, and dynamic behaviour of the active compounds with the sEH enzyme were analysed using in silico molecular docking and dynamics simulations. Our findings suggest that nutmeg could become a promising natural source for discovering and developing new sEH inhibitors. [GRAPHICS] . | Oanh, Vu Thi; Phong, Nguyen Viet; Min, Byung Sun; Yang, Seo Young; Kim, Jeong Ah | Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr, VOICE MRC, Daegu, South Korea; Vietnam Korea Inst Sci & Technol, Biotechnol Dept, Hanoi, Vietnam; Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug D, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Daegu Catholic Univ, Coll Pharm, Drug Res & Dev Ctr, Gyongsan, Gyeongbuk, South Korea; Sangji Univ, Dept Pharmaceut Engn, Wonju, South Korea | Nguyen, Viet Phong/AAQ-4207-2021 | 57218248175; 57205196739; 55663638200; 57215036954; 24722570900 | syyang@sangji.ac.kr;jkim6923@knu.ac.kr; | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | J ENZYM INHIB MED CH | 1475-6366 | 1475-6374 | 38 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL | 2023 | 5.6 | 14.6 | 2.11 | 2025-06-25 | 13 | 12 | Myristica fragrans; nutmeg; myrifralignan; myrifragranone; soluble epoxide hydrolase | ABSOLUTE-CONFIGURATION; ASYMMETRIC-SYNTHESIS; CONSTITUENTS; BIOTRANSFORMATION; PERMEABILITY; DISCOVERY; ARILS; MACE | myrifragranone; myrifralignan; Myristica fragrans; nutmeg; soluble epoxide hydrolase | Epoxide Hydrolases; Lignans; Molecular Docking Simulation; Myristica; Seeds; epoxide hydrolase; malabaricone B; malabaricone C; myrifragranone A; myrifragranone B; myrifragranone C; myrifragranone D; myrifralignan F; myrifralignan G; neolignan; nonanoid derivative; polycyclic aromatic hydrocarbon derivative; unclassified drug; epoxide hydrolase; lignan; Article; computer model; controlled study; drug binding; drug isolation; drug structure; electronic circular dichroism; enzyme activity; enzyme inhibition; enzyme kinetics; IC50; in vitro study; molecular docking; molecular dynamics; nonhuman; nutmeg; pharmacokinetic parameters; plant seed; Myristica | English | 2023 | 2023-12-31 | 10.1080/14756366.2023.2251099 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Prognosis of Performing Split-Rib Bone Graft for Cranial Bone Defects | Background:Frontal sinus anterior wall defects occur because of various diseases, causing not only aesthetic problems, such as forehead bulging and upper eyelid ptosis, but also exerting physical pressure on the brain or optic nerve. Therefore, this study aimed to evaluate the prognosis of performing split-rib bone graft for frontal sinus anterior wall defects.Methods:This study included 30 patients who received a split-rib bone graft for a frontal sinus anterior wall defect. The sizes and volumes of the defects and grafts were measured using three-dimensional computed tomography before, after, and every 6 months for 2 years after the surgery. The Medical Imaging Interaction Toolkit was used for analysis.Results:The average size and volume of the grafts were 27.29 cm2 and 5.88 cm3, whereas they were 23.76 cm2 and 4.80 cm3 at 24 months after surgery, respectively. In a graft size and volume of less than 27 cm2 and 6 cm3, respectively, the rate of graft take was greater than 80% during long-term observation. The younger the age, the higher the rate of graft take. No difference was found in the defect causes. Absorption occurred for up to 18 months.Conclusions:Frontal bone defect reconstruction revealed the stable results of the split-rib bone graft over a long period when the size and volume were less than 27 cm2 and 6 cm3, respectively. Furthermore, bone resorption was seen in more than 20% to 30% of the patients, and the rate of resorption increased with age; thus, it is appropriate to consider overcorrection and other reconstruction methods.CLINICAL QUESTION/LEVEL OF EVIDENCE:Therapeutic, IV. | Hong, Hyun Ki; Ryu, Jeong Yeop; Lee, Joon Seok; Yang, Jung Dug; Chung, Ho Yun; Cho, Byung Chae; Choi, Kang Young | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 130 Dongdeok Ro, Daegu 41944, South Korea | Yang, Jung/R-7806-2019; Ryu, Jeong Yeop/GLQ-9419-2022; LEE, JIN/Q-3108-2018 | 57210147816; 56366349400; 56496041000; 55171704700; 7404007181; 55662871100; 57203745682 | kychoi@knu.ac.kr; | PLASTIC AND RECONSTRUCTIVE SURGERY | PLAST RECONSTR SURG | 0032-1052 | 1529-4242 | 152 | 6 | SCIE | SURGERY | 2023 | 3.2 | 14.6 | 0.33 | 2025-06-25 | 1 | 1 | RECONSTRUCTION | Bone Transplantation; Frontal Bone; Frontal Sinus; Humans; Plastic Surgery Procedures; Prognosis; Ribs; bone transplantation; frontal bone; frontal sinus; human; plastic surgery; procedures; prognosis; rib; surgery | English | 2023 | 2023-12 | 10.1097/prs.0000000000010525 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | Comparison of oncological and functional outcomes between radiofrequency ablation and partial nephrectomy for small renal masses: 1-year followup study | Kim, Yeon Ju; Moon, Young Jun; Kim, Hyeon Woo; Ko, Young Hwii; Seo, Young Jin; Kim, Tae-Hyo; Kwon, Dong Deuk; Chung, Jae-Wook; Kim, Bum Soo | Daegu Fatima Hosp, Dept Urol, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Urol, Daegu, South Korea; Pusan Natl Univ, Sch Med, Dept Urol, Busan, South Korea; Yeungnam Univ, Dept Urol, Coll Med, Daegu, South Korea; Dongguk Univ, Dept Urol, Gyeongju Hosp, Gyeongju, South Korea; Dong A Univ, Sch Med, Dept Urol, Busan, South Korea; Chonnam Natl Univ, Dept Urol, Med Sch, Gwangju, South Korea; Kyungpook Natl Univ, Chilgok Kyungpook Natl Univ Hosp, Sch Med, Dept Urol, Daegu, South Korea | Kim, Yeon-Ju/AAE-5919-2019; Kim, Soo-Yeon/ADR-9663-2022; Ko, Young Hwii/GRX-0718-2022 | BJU INTERNATIONAL | BJU INT | 1464-4096 | 1464-410X | 132 | SCIE | UROLOGY & NEPHROLOGY | 2023 | 3.7 | 14.7 | 0 | English | 2023 | 2023-11 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | Efficacy of immediate postoperative intravesical gemcitabine instillation in nonmuscle invasive bladder cancer | Kim, Bum Soo; Moon, Young Jun; Kim, Yeon Ju; Kim, Hyeon Woo; Ko, Young Hwii; Seo, Young Jin; Kim, Tae-Hyo; Kwon, Dong Deuk; Song, Ki Hak | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Urol, Daegu, South Korea; Daegu Fatima Hosp, Dept Urol, Daegu, South Korea; Pusan Natl Univ, Sch Med, Dept Urol, Busan, South Korea; Yeungnam Univ, Dept Urol, Coll Med, Daegu, South Korea; Dongguk Univ, Dept Urol, Gyeongju Hosp, Gyeongju, South Korea; Dong A Univ, Sch Med, Dept Urol, Busan, South Korea; Chonnam Natl Univ, Dept Urol, Med Sch, Gwangju, South Korea; Chungnam Natl Univ, Sch Med, Dept Urol, Daejeon, South Korea | Kim, Yeon-Ju/AAE-5919-2019; Kim, Soo-Yeon/ADR-9663-2022; Ko, Young Hwii/GRX-0718-2022 | BJU INTERNATIONAL | BJU INT | 1464-4096 | 1464-410X | 132 | SCIE | UROLOGY & NEPHROLOGY | 2023 | 3.7 | 14.7 | 0 | English | 2023 | 2023-11 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | Feasibility of a human fat tissuederived stromal vascular fraction in an interstitial cystitis animal model | Kim, Bum Soo; Moon, Young Jun; Kim, Yeon Ju; Kim, Hyeon Woo; Ko, Young Hwii; Seo, Young Jin; Kim, Tae-Hyo; Kwon, Dong Deuk | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Urol, Daegu, South Korea; Daegu Fatima Hosp, Dept Urol, Daegu, South Korea; Pusan Natl Univ, Sch Med, Dept Urol, Busan, South Korea; Yeungnam Univ, Dept Urol, Coll Med, Daegu, South Korea; Dongguk Univ, Dept Urol, Gyeongju Hosp, Gyeongju, South Korea; Dong A Univ, Sch Med, Dept Urol, Busan, South Korea; Chonnam Natl Univ, Dept Urol, Med Sch, Gwangju, South Korea | Ko, Young Hwii/GRX-0718-2022; Kim, Yeon-Ju/AAE-5919-2019; Kim, Soo-Yeon/ADR-9663-2022 | BJU INTERNATIONAL | BJU INT | 1464-4096 | 1464-410X | 132 | SCIE | UROLOGY & NEPHROLOGY | 2023 | 3.7 | 14.7 | 0 | English | 2023 | 2023-11 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | The impact of multiparametric magnetic resonance imaging for prediction of extra-prostatic extension according to NCCN risk category | Moon, Young Jun; Kim, Yeon Ju; Kim, Hyeon Woo; Ko, Young Hwii; Seo, Young Jin; Kim, Tae-Hyo; Kwon, Dong Deuk; Lee, Jun Nyung; Kim, Bum Soo | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Urol, Daegu, South Korea; Daegu Fatima Hosp, Dept Urol, Daegu, South Korea; Pusan Natl Univ, Sch Med, Dept Urol, Busan, South Korea; Yeungnam Univ, Dept Urol, Coll Med, Daegu, South Korea; Dongguk Univ, Dept Urol, Gyeongju Hosp, Gyeongju, South Korea; Dong A Univ, Sch Med, Dept Urol, Busan, South Korea; Chonnam Natl Univ, Dept Urol, Med Sch, Gwangju, South Korea; Kyungpook Natl Univ, Chilgok Kyungpook Natl Univ Hosp, Sch Med, Dept Urol, Daegu, South Korea | Kim, Soo-Yeon/ADR-9663-2022; Kim, Yeon-Ju/AAE-5919-2019; Ko, Young Hwii/GRX-0718-2022; Kim, Young-Bo/AAR-8052-2021 | BJU INTERNATIONAL | BJU INT | 1464-4096 | 1464-410X | 132 | SCIE | UROLOGY & NEPHROLOGY | 2023 | 3.7 | 14.7 | 0 | English | 2023 | 2023-11 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Appropriateness of antibiotic use for patients with asymptomatic bacteriuria or urinary tract infection with positive urine culture: a retrospective observational multi-centre study in Korea | Background: Antibiotic resistance threatens public health worldwide, and inappropriate use of antibiotics is one of the main causes. Aim: To evaluate qualitative use of antibiotics in asymptomatic bacteriuria (ABU) and urinary tract infection (UTI). Methods: Cases of positive urine culture (>= 10(5) colony-forning units/mL) performed in inpatient, outpatient and emergency departments in April 2021 were screened in 26 hospitals in the Republic of Korea. The cases were classified as ABU, lower UTI and upper UTI. The appropriateness of antibiotic use was evaluated retrospectively by infectious disease specialists using quality indicators based on clinical guidelines for ABU and UTI. Results: This study included a total of 2697 patients with ABU or UTI. The appropriateness of antibiotic use was assessed in 1157 patients with ABU, and in 677 and 863 patients with lower and upper UTI, respectively. Among the 1157 patients with ABU, 251 (22%) were prescribed antibiotics without appropriate indications. In 66 patients with ABU in which antibiotics were prescribed with appropriate indications, the duration was adequate in only 23 (34.8%) patients. The appropriateness of empirical and definite antibiotics was noted in 527 (77.8%) and 353 (68.0%) patients with lower UTI, and 745 (86.3%) and 583 (78.2%) patients with upper UTI, respectively. The duration of antibiotics was adequate in 321 (61.8%) patients with lower UTI and 576 (78.7%) patients with upper UTI. Conclusions: This nationwide qualitative assessment of antibiotic use in ABU and UTI revealed that antibiotics were often prescribed inappropriately, and the duration of antibiotics was unnecessarily prolonged. (c) 2023 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved. | Jung, J.; Moon, S. M.; Kim, D. Y.; Kim, S-h.; Lee, W. J.; Heo, S. T.; Park, J. Y.; Bae, S.; Lee, M. J.; Kim, B.; Park, S. Y.; Jeong, H. W.; Kim, Y.; Kwak, Y. G.; Song, K-h.; Park, K-h.; Park, S. H.; Kim, Y. K.; Kim, E. S.; Kim, H. B. | Soonchunhyang Univ, Seoul Hosp, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Bundang Hosp, Seoul, South Korea; Kyung Hee Univ, Sch Med, Dept Internal Med, Div Infect Dis,Kyung Hee Univ Hosp, Seoul, South Korea; Sungkyunkwan Univ, Samsung Changwon Hosp, Div Infect Dis, Chang Won, South Korea; Hallym Hosp, Dept Internal Med, Incheon, South Korea; Jeju Natl Univ, Dept Internal Med, Div Infect Dis, Coll Med, Jeju, South Korea; Chung Ang Univ Hosp, Dept Paediat, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Infect Dis, Daegu, South Korea; Inje Univ, Sanggye Paik Hosp, Dept Internal Med, Seoul, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Dept Hosp Med, Yongin Severance Hosp, Coll Med, Yongin, South Korea; Yonsei Univ, Coll Med, Dept Biomed Syst Informat, Seoul, South Korea; Yonsei Univ Hlth Syst, Yongin Severance Hosp, Ctr Digital Hlth, Yongin, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Chungbuk, South Korea; Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; Wonkwang Univ, Coll Med, Dept Internal Med, Iksan, South Korea; Inje Univ, Ilsan Paik Hosp, Dept Internal Med, Goyang, South Korea; Chonnam Natl Univ, Med Sch, Dept Infect Dis, Gwangju, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea; Seoul Natl Univ, Bundang Hosp, 82 Gumi Ro 173 Beon gil, Seongnam 13620, Gyeonggi Do, South Korea | Kim, Seog/J-5403-2012; Park, Ji Young/KDO-4256-2024; Jeong, Hye/AET-1982-2022; Kim, Sara/F-2951-2013 | 57205246545; 36554757200; 57205711861; 57194288787; 57207141048; 9737963500; 57022396700; 57219699506; 55520467500; 55622077200; 55259986400; 13103042700; 56658074800; 7103120454; 23398486700; 57219637574; 57061461400; 35322538300; 22938086900; 35307429400 | hbkimmd@snu.ac.kr; | JOURNAL OF HOSPITAL INFECTION | J HOSP INFECT | 0195-6701 | 1532-2939 | 140 | SCIE | INFECTIOUS DISEASES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2023 | 3.9 | 14.8 | 0.36 | 2025-06-25 | 1 | 2 | Antibiotic resistance; Quality assessment of antibiotic use; Asymptomatic bacteriuria; Urinary tract infection | DISEASES SOCIETY; DIAGNOSIS; UPDATE | Antibiotic resistance; Asymptomatic bacteriuria; Quality assessment of antibiotic use; Urinary tract infection | Anti-Bacterial Agents; Bacteriuria; Humans; Republic of Korea; Retrospective Studies; Urinary Tract Infections; antibiotic agent; beta lactam antibiotic; beta lactamase inhibitor; cephalosporin derivative; fosfomycin; quinoline derived antiinfective agent; antiinfective agent; adult; antibiotic sensitivity; Article; asymptomatic bacteriuria; colony forming unit; drug indication; drug use; emergency ward; health care quality; hospital patient; human; major clinical study; medical specialist; multicenter study; observational study; outpatient; practice guideline; prescribing error; prescription; qualitative analysis; retrospective study; South Korea; treatment duration; urinary tract infection; urine culture; bacteriuria; clinical trial; South Korea | English | 2023 | 2023-10 | 10.1016/j.jhin.2023.07.022 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | Epidemiology and comorbid disease of Spinal and bulbar muscular atrophy in South Korea | Park, J.; Park, J. | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Dongguk Univ, Dept Neurol, Coll Med, Gyeongju, South Korea | EUROPEAN JOURNAL OF NEUROLOGY | EUR J NEUROL | 1351-5101 | 1468-1331 | 30 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2023 | 4.5 | 14.8 | 0 | English | 2023 | 2023-06 | 바로가기 | 바로가기 | |||||||||||||||||
| ○ | ○ | Article | Safety and Effectiveness of Regdanvimab for COVID-19 Treatment: A Phase 4 Post-marketing Surveillance Study Conducted in South Korea | IntroductionRegdanvimab, a neutralising monoclonal antibody (mAb) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), received approval for the treatment of coronavirus disease 2019 (COVID-19) in South Korea in 2021. The Ministry of Food and Drug Safety in South Korea mandate that new medications be re-examined for safety and effectiveness post-approval in at least 3000 individuals. This post-marketing surveillance (PMS) study was used to evaluate the safety and effectiveness of regdanvimab in real-world clinical care.MethodsThis prospective, multicentre, phase 4 PMS study was conducted between February 2021 and March 2022 in South Korea. Eligible patients were aged >= 18 years with confirmed mild COVID-19 at high risk of disease progression or moderate COVID-19. Patients were hospitalised and treated with regdanvimab (40 mg/kg, day 1) and then monitored until discharge, with a follow-up call on day 28. Adverse events (AEs) were documented, and the COVID-19 disease progression rate was used to measure effectiveness.ResultsOf the 3123 patients with COVID-19 infection identified, 3036 were eligible for inclusion. Approximately 80% and 5% of the eligible patients were diagnosed with COVID-19 during the delta- and omicron-dominant periods, respectively. Median (range) age was 57 (18-95) years, and 50.6% of patients were male. COVID-19 severity was assessed before treatment, and high-risk mild and moderate COVID-19 was diagnosed in 1030 (33.9%) and 2006 (66.1%) patients, respectively. AEs and adverse drug reactions (ADRs) were experienced by 684 (22.5%) and 363 (12.0%) patients, respectively. The most common ADR was increased liver function test (n = 62, 2.0%). Nine (0.3%) patients discontinued regdanvimab due to ADRs. Overall, 378 (12.5%) patients experienced disease progression after regdanvimab infusion, with extended hospitalisation/re-admission (n = 300, 9.9%) as the most common reason. Supplemental oxygen was required by 282 (9.3%) patients. Ten (0.3%) patients required intensive care monitoring and 3 (0.1%) died due to COVID-19.ConclusionThis large-scale PMS study demonstrated that regdanvimab was effective against COVID-19 progression and had an acceptable safety profile when used in real-world clinical practice. | Lee, Ji Yeon; Bu, Seon Hee; Song, Eunhyang; Cho, Seongcheol; Yu, Sungbong; Kim, Jungok; Kym, Sungmin; Seo, Kwang Won; Kwon, Ki Tae; Kim, Jin Yong; Kim, Sunghyun; Ahn, Keumyoung; Jung, Nahyun; Lee, Yeonmi; Jung, Yoobin; Hwang, Chankyoung; Park, Sang Won | Keimyung Univ, Daegu Dongsan Hosp, Daegu, South Korea; Seoul Metropolitan City Bukbu Hosp, Seoul, South Korea; Seoul Metropolitan City Seobuk Hosp, Seoul, South Korea; Seoul Red Cross Hosp, Seoul, South Korea; Bagae Gen Hosp, Pyeongtaek, South Korea; Chungnam Natl Univ, Sejong Hosp, Sejong, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Obstet & Gynecol, Coll Med, Ulsan, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Incheon Med Ctr, Incheon, South Korea; Celltrion Inc, Incheon, South Korea; Seoul Natl Univ, Dept Internal Med, Boramae Med Ctr, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea | Park, Sang-Won/M-6366-2017; Kim, Hee/F-4594-2014; Kim, Hanjin/KYP-2633-2024; Kim, Jung/L-9791-2019; Kim, Jungok/JWP-9097-2024 | 57216774221; 57193879333; 57219900671; 56965894600; 57913745700; 57207436660; 57190249541; 57209972605; 9733850500; 57211142178; 57219871108; 57911863300; 57226057846; 57226091803; 58647419300; 58648101800; 56108350600 | hswon1@snu.ac.kr; | INFECTIOUS DISEASES AND THERAPY | INFECT DIS THER | 2193-8229 | 2193-6382 | 12 | 10 | SCIE | INFECTIOUS DISEASES | 2023 | 4.7 | 14.8 | 0 | 2025-06-25 | 0 | 0 | COVID-19; CT-P59; Effectiveness; Monoclonal antibody; Neutralising antibody; Post-marketing surveillance; Regdanvimab; Safety; SARS-CoV-2 | VARIANTS; DELTA | COVID-19; CT-P59; Effectiveness; Monoclonal antibody; Neutralising antibody; Post-marketing surveillance; Regdanvimab; Safety; SARS-CoV-2 | alanine aminotransferase; aspartate aminotransferase; regdanvimab; triacylglycerol; adult; aged; antibody dependent enhancement; Article; artificial ventilation; body mass; bradycardia; clinical practice; clinical trial; coronavirus disease 2019; diarrhea; disease severity; dizziness; drug efficacy; drug safety; drug withdrawal; dyspepsia; female; fever; follow up; gastrointestinal disease; hospital readmission; hospitalization; human; hypertransaminasemia; intensive care unit; Korea; liver disease; major clinical study; male; nausea; neutropenia; observational study; oxygen saturation; oxygen therapy; phase 4 clinical trial; postmarketing surveillance; prospective study; pruritus; rash; reverse transcription polymerase chain reaction; risk factor; urticaria | English | 2023 | 2023-10 | 10.1007/s40121-023-00859-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Visualizing mast cell migration to tumor sites using sodium iodide symporter of nuclear medicine reporter gene | Purpose: Owing to the close relationship between mast cells and cancer progression, an imaging technique that can be applied in a clinical setting to explore the biological behavior of mast cells in the tumor microenvironment is needed. In this study, we visualized mast cell migration to lung tumor lesions in live mice using sodium iodide symporter (NIS) as a nuclear medicine reporter gene. Experimental design: The murine mast cell line MC-9 was infected with retrovirus including NIS, luciferase (as a surrogate marker for NIS), and Thy1.1 to generate MC-9/NFT cells. Radioiodine uptake was measured in MC-9/ NFT cells, and an inhibition assay of radioiodine uptake using KCLO4 was also performed. Cell proliferation and Fc & epsilon;RI expression was examined in MC-9 and MC-9/NFT cells. The effect of mast cell-conditioned media (CM) on the proliferation of Lewis lung cancer (LLC) cells was examined. The migration level of MC-9/NFT cells was confirmed in the presence of serum-free media (SFM) and CM of cancer cells. After intravenous injection of MC9/NFT cells into mice with an LLC tumor, I-124 PET/CT and biodistribution analysis was performed. Results: MC-9/NFT cells exhibited higher radioiodine avidity compared to parental MC-9 cells; this increased radioiodine avidity in MC-9/NFT cells was reduced to basal level by KCLO4. Levels of Fc & epsilon;RI expression and cell proliferation were not different in parental MC-9 cell and MC-9/ NFT cells. The CM of MC-9/NFT cells increased cancer cell proliferation relative to that of the SFM. The migration level of MC-9/NFT cells was higher in the CM than the SFM of LLC cells. PET/CT imaging with I-124 clearly showed infiltration of reporter mast cells in lung tumor at 24 h after transfer, which was consistent with the findings of the biodistribution examination. Conclusion: These findings suggest that the sodium iodide symporter can serve as a reliable nuclear medicine reporter gene for non-invasively imaging the biological activity of mast cells in mice with lung tumors. Visualizing mast cells in the tumor microenvironment via a nuclear medicine reporter gene would provide valuable insights into their biological functions. | Oh, Seul-Gi; Choi, Jun Young; Lee, Jae-Eon; Jeon, SoYeon; Lee, Bo-Ra; Son, Kwang Hee; Lee, Sang Bong; An, Beum-Soo; Hwang, Dae Youn; Kim, Seong-Jang; Ha, Ki-Tae; Lee, Jaetae; Jeon, Yong Hyun | Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn K MEDI Hub, Preclincial Res Ctr PRC, Daegu, South Korea; Pusan Natl Univ, Life & Ind Convergence Res Inst, Coll Nat Resources & Life Sci, Dept Biomat Sci,BK21 FOUR Program, Miryang 50463, South Korea; Pusan Natl Univ, Coll Med, Sch Med, Busan, South Korea; Pusan Natl Univ, Sch Korean Med, Dept Korean Med, Yangsan 50612, Gyeongsangnam D, South Korea; Yonsei Univ, Coll Med, Inst Breast Canc Precis Med, Seoul, South Korea; Daegu Gyeongbuk Med Innovat Fdn K MEDI Hub, Preclincial Res Ctr PRC, Chumbok Ro 80, Daegu 41061, South Korea | Kim, Yun Hak/ABF-3331-2021; Jeon, Yong/N-6910-2019; Lee, Sang/I-8954-2014; Kitae, Ha/AFW-2347-2022 | 57188863638; 57188657634; 56808832000; 58523464400; 57221729020; 58099566600; 57190304501; 7007154153; 26325632700; 59103105900; 7102262033; 7601451907; 16042453400 | jeon9014@kmedihub.re.kr; | NEOPLASIA | NEOPLASIA | 1476-5586 | 43 | SCIE | ONCOLOGY | 2023 | 6.3 | 14.8 | 0.14 | 2025-06-25 | 1 | 1 | Mast cells; Nuclear reporter gene imaging; Sodium iodide symporter; Cancer | TRACKING | Cancer; Mast cells; Nuclear reporter gene imaging; Sodium iodide symporter | Animals; Cell Line, Tumor; Cell Movement; Genes, Reporter; Iodine Radioisotopes; Lung Neoplasms; Mice; Nuclear Medicine; Positron Emission Tomography Computed Tomography; Symporters; Tissue Distribution; Tumor Microenvironment; firefly luciferase; iodine 124; radioactive iodine; sodium iodide symporter; cotransporter; Iodine-124; radioactive iodine; sodium iodide symporter; animal experiment; animal model; Article; cancer cell; cell function; cell migration; cell proliferation; controlled study; disease marker; gene expression; in vitro study; Lewis lung carcinoma cell line; lung tumor; mast cell; MC/9 cell line; mouse; nonhuman; nuclear medicine; positron emission tomography-computed tomography; reporter gene; Retroviridae; tumor localization; animal; cell motion; genetics; lung tumor; metabolism; reporter gene; tissue distribution; tumor cell line; tumor microenvironment | English | 2023 | 2023-09 | 10.1016/j.neo.2023.100925 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Cost-of-illness changes before and after the diagnosis of systemic lupus erythematosus: a nationwide, population-based observational study in Korea | Objectives To estimate the direct healthcare cost progression from before to after systemic lupus erythematosus (SLE) diagnosis and to compare healthcare costs by disease severity.Methods Patients with incident SLE diagnosed between 2008 and 2018 were identified from the Korean National Health Insurance database. Annual direct healthcare costs for 5 years before and after SLE were estimated and compared with those of age-, sex- and calendar month-matched (1:4) controls, without SLE. Direct healthcare costs were compared by disease severity of SLE using regression analysis.Results Among 11 173 patients with SLE and 45 500 subjects without SLE, annual direct healthcare costs per person increased in the year before SLE diagnosis and peaked in the first year after diagnosis. They were 7.7-fold greater in the SLE patients than in the subjects without SLE ($5871 vs $759). Severe SLE was associated with 3.284-fold (95% CI: 3.075, 3.507) higher annual costs than mild SLE during the year after diagnosis. Older age (age 60-79 years), lupus nephritis, interstitial lung diseases, and comorbidities such as avascular necrosis and chronic kidney disease were associated with higher annual direct healthcare costs (times [95% CI]) in the first year after diagnosis: age 60-69: 1.119 (1.034, 1.211); age 70-79: 1.470 (1.342, 1.611); lupus nephritis: 1.794 (1.711, 1.881); interstitial lung diseases: 1.435 (1.258, 1.638); avascular necrosis: 6.208 (4.541, 8.487); and chronic kidney disease: 1.858 (1.673, 2.064).Conclusion Patients with SLE incurred significantly higher direct healthcare costs than subjects without SLE during the first year after diagnosis. Disease severity, older age, major organ involvements and comorbidities were associated with increased healthcare costs. | Kim, Hyoungyoung; Jang, Eun Jin; Cho, Soo-Kyung; Han, Jung-Yong; Jeon, Yena; Jung, Sun-Young; Sung, Yoon-Kyoung | Hanyang Univ, Hosp Rheumat Dis, Dept Rheumatol, Seoul, South Korea; Hanyang Univ, Inst Rheumatol Res, Seoul, South Korea; Andong Natl Univ, Dept Informat Stat, Andong, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Chung Ang Univ, Coll Pharm, Seoul, South Korea; Hanyang Univ, Hosp Rheumat Dis, Dept Rheumatol, Seoul 133792, South Korea | Jung, Jaeyun/HZZ-4630-2023 | sungyk@hanyang.ac.kr; | RHEUMATOLOGY | RHEUMATOLOGY | 1462-0324 | 1462-0332 | 64 | 1 | SCIE | RHEUMATOLOGY | 2023 | 4.7 | 14.9 | 2 | systemic lupus erythematosus; healthcare cost; disease severity | HEALTH-CARE UTILIZATION; MEDICAL COSTS; DISEASE COSTS; BURDEN | English | 2023 | 2023-12-23 | 10.1093/rheumatology/kead664 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Metallicity-PAH Relation of MIR-selected Star-forming Galaxies in AKARI North Ecliptic Pole-wide Survey | We investigate the variation in the mid-infrared spectral energy distributions of 373 low-redshift (z < 0.4) star forming galaxies, which reflects a variety of polycyclic aromatic hydrocarbon (PAH) emission features. The relative strength of PAH emission is parameterized as qPAH, which is defined as the mass fraction of PAH particles in the total dust mass. With the aid of continuous mid-infrared photometric data points covering 7-24 mu m and far infrared flux densities, qPAH values are derived through spectral energy distribution fitting. The correlation between qPAH and other physical properties of galaxies, i.e., gas-phase metallicity (12 + log(O/H)), stellar mass, and specific star-formation rate (sSFR) are explored. As in previous studies, q(PAH) values of galaxies with high metallicity are found to be higher than those with low metallicity. The strength of PAH emission is also positively correlated with the stellar mass and negatively correlated with the sSFR. The correlation between q(PAH) and each parameter still exists even after the other two parameters are fixed. In addition to the PAH strength, the application of metallicity-dependent gas-to-dust mass ratio appears to work well to estimate gas mass that matches the observed relationship between molecular gas and physical parameters. The result obtained will be used to calibrate the observed PAH luminosity-total infrared luminosity relation, based on the variation of MIR-FIR SED, which is used in the estimation of hidden star formation. | Shim, Hyunjin; Hwang, Ho Seong; Jeong, Woong-Seob; Toba, Yoshiki; Kim, Minjin; Kim, Dohyeong; Song, Hyunmi; Hashimoto, Tetsuya; Nakagawa, Takago; Nanni, Ambra; Pearson, William J.; Takagi, Toshinobu | Kyungpook Natl Univ, Dept Earth Sci Educ, 80 Daehak ro, Daegu 41566, South Korea; Seoul Natl Univ, Dept Phys & Astron, Astron Program, 1 Gwanak ro, Seoul 08826, South Korea; Seoul Natl Univ, SNU Astron Res Ctr, 1 Gwanak ro, Seoul 08826, South Korea; Korea Astron & Space Sci Inst, 776 Daedeok daero, Daejeon 34055, South Korea; Natl Astron Observ Japan, 2 21 1 Osawa,Mitaka ku, Tokyo 1818588, Japan; Acad Sinica, Inst Astron & Astrophys, 11F Astron Math Bldg,AS NTU,1 Roosevelt Rd, Taipei 10617, Taiwan; Ehime Univ, Res Ctr Space & Cosm Evolut, 2 5 Bunkyo cho, Matsuyama, Ehime 7908577, Japan; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, 80 Daehak ro, Daegu 41566, South Korea; Pusan Natl Univ, Dept Earth Sci, 2, Busandaehak ro 63 beon gil, Busan 46241, South Korea; Chungnam Natl Univ, Dept Astron & Space Sci, 99 Daehak ro, Daejeon 34134, South Korea; Natl Chung Hsing Univ, Dept Phys, 145 Xingda Rd,South Dist, Taichung 402, Taiwan; Japan Aerosp Explorat Agcy, Inst Space & Astronaut Sci, 3 1 1 Yoshinodai,Chuo ku, Sagamihara, Kanagawa 2525210, Japan; Natl Ctr Nucl Res, ul Pasteura 7, PL-02093 Warsaw, Poland; Japan Sci Forum, 3 2 1, Kandasurugadai,Chiyoda ku, Tokyo 1010062, Japan | ; Shim, Hyunjin/LZI-7486-2025; Nanni, Ambra/HLH-1097-2023; Hashimoto, Tetsuya/ABG-3643-2021; HWANG, Ho/AAS-6010-2020; Kim, Minjin/AAU-9910-2020 | 14061137700; 15131707100; 7102145940; 37068332400; 56898213300; 55574223678; 35749280400; 24518043000; 7404044150; 55453605400; 57195032075; 35405904800 | hjshim@knu.ac.kr; | ASTRONOMICAL JOURNAL | ASTRON J | 0004-6256 | 1538-3881 | 165 | 2 | SCIE | ASTRONOMY & ASTROPHYSICS | 2023 | 5.1 | 14.9 | 0.71 | 2025-06-25 | 6 | 6 | Galaxy evolution (594); Infrared galaxies (790); Polycyclic aromatic hydrocarbons (1280); Spectral energy distribution (2129); Galaxy properties (615) | POLYCYCLIC AROMATIC-HYDROCARBON; GAS DEPLETION TIME; INFRARED GALAXIES; NEARBY GALAXIES; MOLECULAR GAS; MIDINFRARED SPECTRA; INTERSTELLAR DUST; FORMATION RATES; OPTICAL SURVEY; SOURCE CATALOG | English | 2023 | 2023-02-01 | 10.3847/1538-3881/aca09c | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | N-methyl-d-aspartate receptors induce M1 polarization of macrophages: Feasibility of targeted imaging in inflammatory response in vivo | BackgroundN-methyl-d-aspartate receptors (NMDARs) are considered to be involved in several physiological and pathophysiological processes in addition to the progression of neurological disorders. However, how NMDARs are involved in the glycolytic phenotype of M1 macrophage polarization and the possibility of using them as a bio-imaging probe for macrophage-mediated inflammation remain unclear.MethodsWe analyzed cellular responses to NMDAR antagonism and small interfering RNAs using mouse bone marrow-derived macrophages (BMDMs) treated with lipopolysaccharide (LPS). An NMDAR targeting imaging probe, N-TIP, was produced via the introduction of NMDAR antibody and the infrared fluorescent dye FSD Fluor (TM) 647. N-TIP binding efficiency was tested in intact and LPS-stimulated BMDMs. N-TIP was intravenously administered to mice with carrageenan (CG)- and LPS-induced paw edema, and in vivo fluorescence imaging was conducted. The anti-inflammatory effects of dexamethasone were evaluated using the N-TIP-mediated macrophage imaging technique.ResultsNMDARs were overexpressed in LPS-treated macrophages, subsequently inducing M1 macrophage polarization. Mechanistically, NMDAR-mediated Ca2+ accumulation resulted in LPS-stimulated glycolysis via upregulation of PI3K/AKT/mTORC1 signaling. In vivo fluorescence imaging with N-TIP showed LPS- and CG-induced inflamed lesions at 5 h post-inflammation, and the inflamed lesions could be detected until 24 h. Furthermore, our N-TIP-mediated macrophage imaging technique helped successfully visualize the anti-inflammatory effects of dexamethasone in mice with inflammation.ConclusionThis study demonstrates that NMDAR-mediated glycolysis plays a critical role in M1 macrophage-related inflammation. Moreover, our results suggest that NMDAR targeting imaging probe may be useful in research on inflammatory response in vivo. | Jeon, Hui-Jeon; Byun, Jun-Kyu; Lee, Sang Bong; Son, Kwang Hee; Lim, Ji-Youn; Lee, Da Sol; Kim, Kil Soo; Park, Jin Woo; Shin, Gyeong Rim; Kim, Ye Jin; Jin, Jonghwa; Kim, Daehoon; Kim, Dong-Ho; Yu, Ji Hoon; Choi, Yeon-Kyung; Park, Keun-Gyu; Jeon, Yong Hyun | Daegu Gyeongbuk Med Innovat Fdn KMEDIhub, New Drug Dev Ctr, 80 Chembok Ro, Daegu 41061, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, BK21 Community Based Intelligent Novel Drug Discov, Daegu 41566, South Korea; THERABEST Co Ltd, Seoul 06657, South Korea; Daegu Gyeongbuk Med Innovat Fdn KMEDIhub, Preclin Res Ctr, Daegu 41061, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; BioActs Co Ltd, Incheon 21666, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Internal Med, Daegu 41404, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet &, Daegu 41404, South Korea | Jeon, Yong/N-6910-2019; Kim, Seung/N-5248-2019 | 57193694479; 57190427423; 57190304501; 58099566600; 55632953200; 57226045679; 35272034300; 57209247977; 58171235800; 57207443325; 57223246243; 58171035100; 57986980100; 14526268100; 35335932600; 57202558343; 16042453400 | ykchoi@knu.ac.kr;kpark@knu.ac.kr;jeon9014@dgmif.re.kr; | CELL AND BIOSCIENCE | CELL BIOSCI | 2045-3701 | 13 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2023 | 6.1 | 14.9 | 0.21 | 2025-06-25 | 2 | 2 | Macrophage; N-methyl-d-aspartate receptors; Inflammation; Antibody-mediated imaging; Near-infrared fluorescent | NMDA RECEPTOR; CATHEPSIN-B; ACTIVATION; METABOLISM; EXPRESSION; HYPOXIA; SIGNAL; IL-1-BETA; PATHWAY; MUSCLE | Antibody-mediated imaging; Inflammation; Macrophage; N-methyl-d-aspartate receptors; Near-infrared fluorescent | carrageenan; dexamethasone; fluorescent dye; inducible nitric oxide synthase; lipopolysaccharide; mammalian target of rapamycin complex 1; n methyl dextro aspartic acid receptor; n methyl dextro aspartic acid receptor antibody; phosphatidylinositol 3 kinase; protein kinase B; small interfering RNA; animal cell; animal experiment; animal model; antiinflammatory activity; Article; bone marrow derived macrophage; calcium cell level; calcium signaling; cell membrane; controlled study; drug efficacy; evaluation study; feasibility study; female; fluorescence imaging; gene overexpression; glycolysis; in vivo study; inflammation; infrared radiation; lipopolysaccharide-induced inflammation; M1 macrophage; macrophage; male; mouse; nonhuman; paw edema; peritoneum macrophage; phenotype; polarization; protein expression; protein function; protein phosphorylation; signal transduction; thin layer chromatography; upregulation | English | 2023 | 2023-03-30 | 10.1186/s13578-023-01007-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A rise in HFC-23 emissions from eastern Asia since 2015 | Trifluoromethane (CHF 3 , HFC-23), one of the most potent greenhouse gases among hydrofluorocarbons (HFCs), is mainly emitted to the atmosphere as a by-product in the production of the ozone-depleting legacy refrigerant and chemical feedstock chlorodifluoromethane (CHClF 2 , HCFC-22). A recent study on atmospheric observation-based global HFC-23 emissions (top-down estimates) showed significant discrepancies over 2014-2017 between the increase in the observation-derived emissions and the 87 % emission reduction expected from capture and destruction processes of HFC-23 at HCFC-22 production facilities implemented by national phase-out plans (bottom-up emission estimates) (Stanley et al., 2020). However, the actual regions responsible for the increased emissions were not identified. Here, we estimate the regional top-down emissions of HFC-23 for eastern Asia based on in situ measurements at Gosan, South Korea, and show that the HFC-23 emissions from eastern China have increased from 5.0 +/- 0.4 Gg yr - 1 in 2008 to 9.5 +/- 1.0 Gg yr - 1 in 2019. The continuous rise since 2015 was contrary to the large emissions reduction reported under the Chinese hydrochlorofluorocarbons production phase-out management plan (HPPMP). The cumulative difference between top-down and bottom-up estimates for 2015-2019 in eastern China was similar to 23.7 +/- 3.6 Gg, which accounts for 47 +/- 11 % of the global mismatch. Our analysis based on HCFC-22 production information suggests the HFC-23 emissions rise in eastern China is more likely associated with known HCFC-22 production facilities rather than the existence of unreported, unknown HCFC-22 production, and thus observed discrepancies between top-down and bottom-up emissions could be attributed to unsuccessful factory-level HFC-23 abatement and inaccurate quantification of emission reductions. | Park, Hyeri; Kim, Jooil; Choi, Haklim; Geum, Sohyeon; Kim, Yeaseul; Thompson, Rona L.; Muhle, Jens; Salameh, Peter K.; Harth, Christina M.; Stanley, Kieran M.; O'Doherty, Simon; Fraser, Paul J.; Simmonds, Peter G.; Krummel, Paul B.; Weiss, Ray F.; Prinn, Ronald G.; Park, Sunyoung | Kyungpook Natl Univ, Dept Oceanog, Daegu, South Korea; Univ Calif San Diego, Scripps Inst Oceanog SIO, La Jolla, CA USA; Kyungpook Natl Univ, Kyungpook Inst Oceanog, Daegu, South Korea; Norwegian Inst Air Res NILU, Kjeller, Norway; Univ Bristol, Sch Chem, Bristol, England; Commonwealth Sci & IndRes Org CSIRO Oceans & Atmos, Climate Sci Ctr, Aspendale, Vic, Australia; MIT, Ctr Global Change Sci, Cambridge, MA USA | Krummel, Paul/A-4293-2013; Fraser, Paul/D-1755-2012; Muhle, Jens/GPX-3244-2022 | 57217629478; 36142937600; 57215186877; 57659961800; 57232849000; 55482250100; 55917306500; 6602378882; 8878471400; 36134921000; 6603729725; 7202782061; 7102204006; 6602579613; 7404027402; 7005942405; 57085459500 | sparky@knu.ac.kr; | ATMOSPHERIC CHEMISTRY AND PHYSICS | ATMOS CHEM PHYS | 1680-7316 | 1680-7324 | 23 | 16 | SCIE | ENVIRONMENTAL SCIENCES;METEOROLOGY & ATMOSPHERIC SCIENCES | 2023 | 5.2 | 15.0 | 1.48 | 2025-06-25 | 9 | 9 | ATMOSPHERIC GASES; HALOCARBONS | Cheju [South Korea]; China; Gosan; South Korea; bottom-up approach; emission control; greenhouse gas; hydrofluorocarbon; in situ measurement; top-down approach | English | 2023 | 2023-08-25 | 10.5194/acp-23-9401-2023 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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