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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Epidemiological characteristics of a COVID-19 outbreak caused by religious activities in Daegu, Korea | OBJECTIVES: A coronavirus disease 2019 (COVID-19) outbreak triggered by religious activities occurred in Daegu, Korea in February 2020. This outbreak spread rapidly to the community through high-risk groups. This study describes the characteristics of COVID-19 cases based on S religious group membership and summarizes the Daegu municipal government's processes and responses to control the outbreak. METHODS: The epidemiological characteristics of confirmed cases were obtained through basic and in-depth epidemiological surveys. General characteristics, the proportion of asymptomatic cases, the case-fatality rate, and the time-to-event within each group were presented after stratifying confirmed cases according to S religious group membership. RESULTS: Overall, 7,008 COVID-19 cases were confirmed in Daegu from February 18, 2020 to June 30, 2020, and 61.5% (n= 4,309) were S religious group members. Compared with non-members, members had a higher proportion of female (p= 60 years was significantly higher than that of members (p<0.001). Compared with non-members, members had longer intervals from symptom onset to diagnosis (p<0.001) and from diagnosis to admission (p<0.001), and a shorter interval from admission to discharge (p<0.001). CONCLUSIONS: The epidemiological features of S religious group members, including the proportion of asymptomatic cases, case-fatality rate, and time-to-event, differed from non-members. The Daegu authorities prevented further COVID-19 spread through immediate isolation and active screening tests of all S religious group members. | Kim, Jong-Yeon; Lee, Yu-Mi; Lee, Hwajin; Kim, Jung-Whan; Kim, Shin-Woo | Kyungpook Natl Univ Hosp, Dept Publ Hlth, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea | ; Kim, Sun/G-3451-2013; Lee, Hwajin/LLK-7577-2024 | 58382951500; 57075191600; 57224495869; 57224495334; 8710731500 | ksw2kms@knu.ac.kr; | EPIDEMIOLOGY AND HEALTH | EPIDEMIOL HEALTH | 2092-7193 | 43 | SCIE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 5.919 | 20.7 | 0.87 | 2025-07-30 | 9 | 10 | Coronavirus; COVID-19; Disease outbreaks; Epidemiologic surveillance; Religion; Korea | Coronavirus; COVID-19; Disease outbreaks; Epidemiologic surveillance; Korea; Religion | Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; COVID-19; Disease Outbreaks; Epidemiological Monitoring; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Religion; Republic of Korea; Young Adult; adolescent; aged; Article; case fatality rate; child; clinical feature; controlled study; coronavirus disease 2019; female; government; health survey; human; infant; infection control; Korea; major clinical study; male; newborn; pandemic; priority journal; religious group; adult; epidemic; epidemiological monitoring; epidemiology; middle aged; preschool child; religion; South Korea; very elderly; young adult | English | 2021 | 2021-04-14 | 10.4178/epih.e2021024 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Estimation and change of edentulism among the Korean population: Korea National Health and Nutrition Examination Survey 2007-2018 | OBJECTIVES: To estimate the prevalence of edentulism according to the socio-demographic variables of Korean adults between 2007 and 2018 and to analyze the trends. METHODS: This study was conducted using raw data from the Korea National Health and Nutrition Examination Survey (KNHANES) from 2007 to 2018. Edentulism was defined as the absence of upper and lower teeth or the retained root of the missing teeth. To obtain the prevalence of edentulism, complex sample frequency analysis and regression analysis were performed according to the socio-demographic variables to represent the national population. The Korean population structure in 2005 was exploited as a standard population to calculate age-standardized edentulism. RESULTS: The prevalence of edentulism in 2016-2018 was 9.7% in the Korean elderly, and the change of age-standardized edentulism steadily declined over time from 2007, 12.8%. In particular, it decreased by approximately 20% in the period between 2016 and 2018 compared to that in 2007 for those in their 80s. The trend of the prevalence according to gender decreased significantly in women. According to the level of education, the greatest decrease was seen in the group with the lowest education, although the prevalence itself was higher than that seen in those who were more educated. CONCLUSIONS: The prevalence of edentulism among the older Korean population has decreased over time. However, the concern is on those with lower education and men as these groups are still at higher risk for edentulism. | Yu, Na-Hyeon; Shin, Ah Ra; Ahn, Song Vogue; Song, Keun-Bae; Choi, Youn-Hee | Kyungpook Natl Univ, Sch Dent, Dept Prevent Dent, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Gumi Univ, Dept Dent Hyg, Gumi, South Korea; Ewha Womans Univ, Dept Hlth Convergence, Seoul, South Korea | Ahn, Song/AAK-2900-2021 | 57224145610; 57224143653; 47360986600; 35105905200; 7404777239 | cyh1001@knu.ac.kr; | EPIDEMIOLOGY AND HEALTH | EPIDEMIOL HEALTH | 2092-7193 | 43 | SCIE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 5.919 | 20.7 | 0.8 | 2025-07-30 | 10 | 8 | Oral health; Edentulism; Prevalence; Tooth loss; Korea National Health and Nutrition Examination Survey | TOOTH LOSS; ORAL-HEALTH; TEETH; RISK | Edentulism; Korea National Health and Nutrition Examination Survey; Oral health; Prevalence; Tooth loss | Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Nutrition Surveys; Prevalence; Republic of Korea; Socioeconomic Factors; Tooth Loss; Young Adult; adult; age distribution; aged; Article; controlled study; edentulism; educational status; female; human; human tissue; Korean (people); major clinical study; male; middle aged; prevalence; priority journal; sex ratio; social status; sociodemographics; standardization; trend study; very elderly; young adult; nutrition; periodontal disease; prevalence; socioeconomics; South Korea | English | 2021 | 2021-04-02 | 10.4178/epih.e2021020 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Identification of Decrease in TRiC Proteins as Novel Targets of Alpha-Amanitin-Derived Hepatotoxicity by Comparative Proteomic Analysis In Vitro | Alpha-amanitin (alpha-AMA) is a cyclic peptide and one of the most lethal mushroom amatoxins found in Amanita phalloides. alpha-AMA is known to cause hepatotoxicity through RNA polymerase II inhibition, which acts in RNA and DNA translocation. To investigate the toxic signature of alpha-AMA beyond known mechanisms, we used quantitative nanoflow liquid chromatography-tandem mass spectrometry analysis coupled with tandem mass tag labeling to examine proteome dynamics in Huh-7 human hepatoma cells treated with toxic concentrations of alpha-AMA. Among the 1828 proteins identified, we quantified 1563 proteins, which revealed that four subunits in the T-complex protein 1-ring complex protein decreased depending on the alpha-AMA concentration. We conducted bioinformatics analyses of the quantified proteins to characterize the toxic signature of alpha-AMA in hepatoma cells. This is the first report of global changes in proteome abundance with variations in alpha-AMA concentration, and our findings suggest a novel molecular regulation mechanism for hepatotoxicity. | Kim, Doeun; Kim, Sunjoo; Na, Ann-Yae; Sohn, Chang Hwan; Lee, Sangkyu; Lee, Hye Suk | Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Catholic Univ Korea, Coll Pharm, BK21 FOUR Sponsored Adv Program SmartPharma Leade, Bucheon 14662, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Emergency Med, Seoul 05505, South Korea | Kim, Doeun/NJR-1829-2025 | 57219650718; 57051715600; 57201530058; 35933678400; 57209046767; 35316111800 | kdkd11230@gmail.com;tjswn712@nate.com;cpblady@daum.net;schwan97@gmail.com;sangkyu@knu.ac.kr;sianalee@catholic.ac.kr; | TOXINS | TOXINS | 2072-6651 | 13 | 3 | SCIE | FOOD SCIENCE & TECHNOLOGY;TOXICOLOGY | 2021 | 5.075 | 20.7 | 0.63 | 2025-07-30 | 9 | 9 | alpha-amanitin; comparative quantitative proteomics; TRiC; hepatotoxicity | CHAPERONIN CCT; CRYSTAL-STRUCTURE; COMPLEX; CONFORMATION; EXPRESSION | alpha-amanitin; comparative quantitative proteomics; hepatotoxicity; TRiC | Alpha-Amanitin; Cell Line, Tumor; Chaperonin Containing TCP-1; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Computational Biology; Humans; Liver; Mushroom Poisoning; Protein Interaction Maps; Proteome; Proteomics; Tandem Mass Spectrometry; alpha amanitin; protein; RNA polymerase II; T complex protein 1 ring complex; unclassified drug; alpha amanitin; chaperonin containing TCP1; proteome; Article; bioinformatics; cell death; cell proliferation; cell viability; comparative study; cytotoxicity; down regulation; gene ontology; Huh-7 cell line; human; human cell; in vitro study; KEGG; liquid chromatography-mass spectrometry; liver cell line; liver toxicity; protein folding; protein misfolding; protein synthesis; protein targeting; proteomics; upregulation; Western blotting; biology; drug effect; liquid chromatography; liver; metabolism; mushroom poisoning; protein analysis; tandem mass spectrometry; toxic hepatitis; tumor cell line | English | 2021 | 2021-03 | 10.3390/toxins13030197 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Possible Cause of Seasonal Inhomogeneity in Interdecadal Changes of Tropical Cyclone Genesis Frequency over the Western North Pacific | An abrupt decrease in annual tropical cyclone genesis frequency (TCGF), which is statistically significant only from October to December (OND), has been noticed over the western North Pacific Ocean. However, the seasonal inhomogeneity of interdecadal changes in TCGF between OND and the other seasons (from January to September) and the associated mechanisms are not clearly documented. This study examines and compares the different interdecadal changes in OND and in January-September from 1979 to 2018. According to our analysis, the TCGF decrease in OND (2.2) accounts for 79% of the total decrease (2.8) in annual 'TCGF after 1998, whereas the TCGF in January to September remains unchanged. The key differences in large-scale environment are found from the extension of equatorial easterly wind anomalies and attendant anticyclone anomalies in the subtropics. Under similar sea surface temperature (SST) warming pattern in the tropical Indo-Pacific region (i.e., the La Nifia-like SST warming), tropical precipitation is significantly enhanced over the area where its seasonal peak occurs: the tropical Indian Ocean in OND and the tropical western Pacific in January-September. Thus, the equatorial easterly wind anomalies extend westward to 110 degrees E in OND and to 145 degrees E in January-September. Different extension of easterly wind anomalies results in different expansion of attendant large-scale anticyclone anomaly over the subtropical western Pacific, which dominates the entire main development region in OND but not in January-September. To summarize, the different extensions of easterly wind anomalies under similar La Nina-like SST warming are responsible for the seasonal inhomogeneity of interdecadal changes in TCGF. | Chang, Minhee; Park, Doo-Sun R.; Ho, Chang-Hoi | Seoul Natl Univ, Sch Earth & Environm Sci, Seoul, South Korea; Kyungpook Natl Univ, Dept Earth Sci Educ, Daegu, South Korea | Park, Doo-Sun/U-9448-2019; Ho, Chang-Hoi/H-8354-2015 | 57193331972; 37117659000; 7404653593 | dsrpark@knu.ac.kr; | JOURNAL OF CLIMATE | J CLIMATE | 0894-8755 | 1520-0442 | 34 | 2 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2021 | 5.38 | 20.7 | 0.68 | 2025-07-30 | 11 | 11 | Tropical cyclones; Interdecadal variability | Interdecadal variability; Tropical cyclones | Indian Ocean; Indian Ocean (Tropical); Pacific Ocean; Pacific Ocean (North); Pacific Ocean (Tropical); Hurricanes; Storms; Surface waters; Tropics; Associated mechanism; Interdecadal changes; Sea surface temperature (SST); Tropical cyclone; Tropical Indian ocean; Tropical precipitation; Tropical Western Pacific; Western North Pacific; atmospheric dynamics; cyclogenesis; decadal variation; easterly wave; homogeneity; sea surface temperature; seasonal variation; tropical cyclone; warming; wind field; Oceanography | English | 2021 | 2021-01 | 10.1175/jcli-d-20-0268.1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Trim46 contributes to the midbrain development via Sonic Hedgehog signaling pathway in zebrafish embryos | TRIM46 is a RING finger E3 ligase which belongs to TRIM (tripartite motif-containing) protein family. TRIM46 is required for neuronal polarity and axon specification by driving the formation of parallel microtubule arrays, whereas its embryological functions remain to be determined yet. Expression patterns and biological functions of trim46a, a zebrafish homologue of TRIM46, were studied in zebrafish embryo. First, maternal transcripts of trim46a were present at 1 cell stage whereas zygotic messages were abundant in the eyes, MHB (Midbrain-Hindbrain Boundary) and hindbrain at 24 hpf (hours post fertilization). Second, transcriptional regulatory region of trim46a contains cis-acting elements binding a transcriptional factor Foxa2. Transcription of foxa2 is positively regulated by Sonic Hedgehog (SHH), and treatment of cyclopamine, an SHH inhibitor, represses transcription of foxa2 in 4 hpf through 24 hpf embryos. Third, the transcriptional repression of foxa2 inhibited transcription of trim46a to cause developmental defects in the midbrain and MHB. Finally, spatiotemporal expression patterns of a midbrain marker otx2b in the developmental defects confirmed inhibition of SHH by cyclopamine caused underdevelopment of the midbrain and MHB at 24 hpf. We propose a signaling network where trim46a contributes to development of the midbrain and MHB via Foxa2, a downstream element of SHH signaling in zebrafish embryogenesis. | Jung, Jangham; Kim, Jaehun; Huh, Tae-Lin; Rhee, Myungchull | Grad Sch, Plus Program BK21, Dept Life Sci, Daejeon, South Korea; Chungnam Natl Univ, Coll Biosci & Biotechnol, Dept Biol Sci, Daejeon 34134, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Daegu, South Korea | 57206894285; 57222320730; 7007119367; 7102347645 | mrhee@cnu.ac.kr; | ANIMAL CELLS AND SYSTEMS | ANIM CELLS SYST | 1976-8354 | 2151-2485 | 25 | 1 | SCIE | CELL BIOLOGY;ZOOLOGY | 2021 | 2.398 | 20.7 | 0.6 | 2025-07-30 | 11 | 7 | Trim46a; Sonic Hedgehog (SHH); Foxa2; midbrain; MHB (Midbrain-Hindbrain boundary); cyclopamine | cyclopamine; Foxa2; MHB (Midbrain-Hindbrain boundary); midbrain; Sonic Hedgehog (SHH); Trim46a | English | 2021 | 2021-01-02 | 10.1080/19768354.2021.1889661 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Analytical derivatives of the individual state energies in ensemble density functional theory. II. Implementation on graphical processing units (GPUs) | Conical intersections control excited state reactivity, and thus, elucidating and predicting their geometric and energetic characteristics are crucial for understanding photochemistry. Locating these intersections requires accurate and efficient electronic structure methods. Unfortunately, the most accurate methods (e.g., multireference perturbation theories such as XMS-CASPT2) are computationally challenging for large molecules. The state-interaction state-averaged restricted ensemble referenced Kohn-Sham (SI-SA-REKS) method is a computationally efficient alternative. The application of SI-SA-REKS to photochemistry was previously hampered by a lack of analytical nuclear gradients and nonadiabatic coupling matrix elements. We have recently derived analytical energy derivatives for the SI-SA-REKS method and implemented the method effectively on graphical processing units. We demonstrate that our implementation gives the correct conical intersection topography and energetics for several examples. Furthermore, our implementation of SI-SA-REKS is computationally efficient, with observed sub-quadratic scaling as a function of molecular size. This demonstrates the promise of SI-SA-REKS for excited state dynamics of large molecular systems. | Liu, Fang; Filatov, Michael; Martinez, Todd J. | Emory Univ, Dept Chem, 1515 Pierce Dr, Atlanta, GA 30322 USA; Kyungpook Natl Univ, Dept Chem, Daegu 702701, South Korea; Stanford Univ, Dept Chem, Stanford, CA 94305 USA; Stanford Univ, PULSE Inst, Stanford, CA 94305 USA; SLAC Natl Accelerator Lab, Menlo Pk, CA 94025 USA | Martinez, Todd/HDN-6985-2022; Martinez, Todd/F-4306-2010; Liu, Fang/S-1267-2019 | 56999432400; 7005134246; 7102270609 | fang.liu@emory.edu;toddjmartinez@gmail.com; | JOURNAL OF CHEMICAL PHYSICS | J CHEM PHYS | 0021-9606 | 1089-7690 | 154 | 10 | SCIE | CHEMISTRY, PHYSICAL;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2021 | 4.304 | 20.8 | 0.6 | 2025-07-30 | 8 | 8 | Chemical bonds; Chemical reactions; Computational efficiency; Density functional theory; Electronic structure; Excited states; Perturbation techniques; Program processors; Topography; Analytical derivative; Computationally efficient; Conical intersection; Energetic characteristics; Excited-state dynamics; Graphical processing unit (GPUs); Nonadiabatic coupling matrix elements; Perturbation theory; article; density functional theory; molecular size; photochemistry; topography; Graphics processing unit | English | 2021 | 2021-03-14 | 10.1063/5.0041389 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Blockwise Phase Rotation-Aided Analog Transmit Beamforming for 5G mmWave Systems | In this letter, we propose a blockwise phase rotation-aided analog transmit beamforming (BPR-ATB) scheme to improve the spectral efficiency and the bit-error-rate (BER) performance in millimeter wave (mmWave) communication systems. Due to the phase angle optimization issues of the conventional analog beamforming, we design the BPR-ATB for reducing the rotated beamspace of the equivalent channel and improving the minimum Euclidean distance. To verify the effectiveness of the proposed BPR-ATB scheme, we employ an Alamouti coding technique at the transmitter and evaluate the bit-error-rate performance for mmWave multiple-input and single-output systems. The simulation results show that the proposed BPR-ATB scheme outperforms the conventional discrete Fourier transform-based ATB scheme. | Sarker, Md Abdul Latif; Orikumhi, Igbafe; Han, Dong Seog; Kim, Sunwoo | Hanyang Univ, Dept Elect & Comp Engn, Seoul 04763, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | Kim, Sunwoo/HHC-8228-2022; Han, Dong Seog/N-8949-2018 | 42262729500; 56964499600; 7403219442; 57194160623 | abdul123@hanyang.ac.kr;oigbafe2@hanyang.ac.kr;dshan@knu.ac.kr;remero@hanyang.ac.kr; | IEEE WIRELESS COMMUNICATIONS LETTERS | IEEE WIREL COMMUN LE | 2162-2337 | 2162-2345 | 10 | 11 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2021 | 5.281 | 20.8 | 0.2 | 2025-07-30 | 2 | 3 | Optimized production technology; Array signal processing; Optimization; Transmitting antennas; Receiving antennas; Millimeter wave communication; Euclidean distance; 5G-millimeter-wave systems; blockwise phase rotation; Alamouti coding; spectral; and BER performance | MIMO; ARCHITECTURE; DESIGN | 5G-millimeter-wave systems; Alamouti coding; and BER performance; blockwise phase rotation; spectral | Beamforming; Discrete Fourier transforms; Millimeter waves; Analog beamforming; Bit error rate (BER) performance; Equivalent channels; Millimeter waves (mmwave); Minimum euclidean distances; Single-output systems; Spectral efficiencies; Transmit beamforming; Bit error rate | English | 2021 | 2021-11 | 10.1109/lwc.2021.3100614 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Charge transfer plasmons in the arrays of nanoparticles connected by conductive linkers | Charge transfer plasmons (CTPs) that occur in different topology and dimensionality arrays of metallic nanoparticles (NPs) linked by narrow molecular bridges are studied. The occurrence of CTPs in such arrays is related to the ballistic motion of electrons in thin linkers with the conductivity that is purely imaginary, in contrast to the case of conventional CTPs, where metallic NPs are linked by thick bridges with the real optical conductivity caused by carrier scattering. An original hybrid model for describing the CTPs with such linkers has been further developed. For different NP arrays, either a general analytical expression or a numerical solution has been obtained for the CTP frequencies. It has been shown that the CTP frequencies lie in the IR spectral range and depend on both the linker conductivity and the system geometry. It is found that the electron currents of plasmon oscillations correspond to minor charge displacements of only few electrons. It has been established that the interaction of the CTPs with an external electromagnetic field strongly depends on the symmetry of the electron currents in the linkers, which, in turn, are fully governed by the symmetry of the investigated system. The extended model and the analytical expressions for the CTPs frequencies have been compared with the conventional finite difference time domain simulations. It is argued that applications of this novel type of plasmon may have wide ramifications in the area of chemical sensing. | Fedorov, A. S.; Visotin, M. A.; Gerasimov, V. S.; Polyutov, S. P.; Avramov, P. A. | Siberian Fed Univ, Int Res Ctr Spect & Quantum Chem IRC SQC, Krasnoyarsk 660041, Russia; RAS, Fed Res Ctr KSC SB, Kirensky Inst Phys, Krasnoyarsk 660036, Russia; Natl Res Tomsk State Univ, Tomsk 634050, Russia; RAS, Fed Res Ctr KSC SB, Inst Computat Modelling, Krasnoyarsk 660036, Russia; FMBA Russia, Fed Siberian Res Clin Ctr, Krasnoyarsk 660037, Russia; Kyungpook Natl Univ, Daegu 41566, South Korea | Gerasimov, Valeriy/E-7549-2014; Fedorov, Aleksandr/AAC-1671-2022; Fedorov, Aleksandr/E-8658-2014; Polyutov, Sergey/M-6417-2013 | 14057983200; 56120434000; 7201614977; 6507259627; 7004322420 | alex99@iph.krasn.ru;spolyutov@sfu-kras.ru; | JOURNAL OF CHEMICAL PHYSICS | J CHEM PHYS | 0021-9606 | 1089-7690 | 154 | 8 | SCIE | CHEMISTRY, PHYSICAL;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2021 | 4.304 | 20.8 | 0.38 | 2025-07-30 | 5 | 6 | Chemical sensors; Electromagnetic fields; Electrons; Finite difference time domain method; Nanoparticles; Optical conductivity; Plasmons; Time domain analysis; Analytical expressions; Carrier scattering; Charge displacement; External electromagnetic field; Finite difference time domain simulations; Metallic nanoparticles; Numerical solution; Plasmon oscillations; Charge transfer | English | 2021 | 2021-02-28 | 10.1063/5.0040128 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Pilot and Data Power Allocation in Poisson Interference Field With Protected Zone for Physical-Layer Security | Physical-layer security has become widely recognized as a promising technique to enhance wireless security by exploiting the characteristics including fading, noise, and interference. This letter explores an opportunity to enhance physical-layer security by balancing the power expense between pilot and payload signals without any prior knowledge related to eavesdroppers. In lieu of presuming perfect channel acquisition, we consider a practical wiretap channel with the receivers enabled by pilot-aided channel estimation (CE). The problem is tackled by accounting for the network interference from cochannel interferers in unknown locations by which the secrecy level is significantly affected. Specifically, the secrecy transmission rate (STR) reflecting the CE errors is derived for the worst-case within the use of a protected zone. We investigate the feasible region of pilot and data power allocation under reliability and secrecy constraints, and the optimal power allocation for pilot and data to maximize the STR is proposed, whose performance is verified via simulations. | Ahn, Sungjun; Park, Sung-Ik; Kang, Joonhyuk; Jeong, Seongah | Elect & Telecommun Res Inst, Media Res Div, Daejeon 305700, South Korea; Korea Adv Inst Sci & Technol, Dept Elect Engn, Daejeon 305702, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | Park, Sung-Ik/AAY-2030-2021; Jeong, Seongah/ABW-7285-2022; Jeong, Seongah/I-2863-2017 | 57203589446; 56377353200; 7404517651; 55210226900 | sjahn@etri.re.kr;psi76@etri.re.kr;jhkang@ee.kaist.ac.kr;seongah@knu.ac.kr; | IEEE WIRELESS COMMUNICATIONS LETTERS | IEEE WIREL COMMUN LE | 2162-2337 | 2162-2345 | 10 | 2 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2021 | 5.281 | 20.8 | 0.27 | 2025-07-30 | 3 | 4 | Security; Interference; Channel estimation; Resource management; Fading channels; Payloads; Receivers; Physical-layer security; stochastic geometry; protected zone; pilot-data power allocation | NETWORKS | Physical-layer security; pilot-data power allocation; protected zone; stochastic geometry | Electrical engineering; Electronics engineering; Cochannel interferers; Interference field; Network interferences; Optimal power allocation; Physical layer security; Pilot aided channel estimations; Transmission rates; Wireless security; Physical layer | English | 2021 | 2021-02 | 10.1109/lwc.2020.3027838 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Two-Stage Thompson Sampling for Outer-Loop Link Adaptation | In this letter, we consider outer-loop link adaptation, wherein we pursue to find the optimum modulation and coding scheme (MCS) that provides the maximum throughput without directly estimating the channel state. We cast this problem in a form of multi-armed bandit, an online decision making policy based on sequential observations. To efficiently solve a formulated problem, we propose a novel two-stage Thompson sampling. The proposed method is built based on the observation that the optimum MCS level appears in a certain group that satisfies feasibility conditions. Exploiting this feature, we find the optimum MCS level via two stages. In the first stage, we identify a group that has high probability of including the optimum MCS. In the second stage, we only focus on the MCS levels within the identified group in the first stage, and investigate the optimum MCS. By doing this, the search space is significantly reduced, which leads to the performance improvement. Simulation results show that the proposed method outperforms the existing state-of-art algorithm. | Park, Jeonghun; Baek, Seungkwon | Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, Daegu 41566, South Korea; ETRI, Mobile Commun Res Div, Daejeon 34129, South Korea | 57853652900; 16068033800 | jeonghun.park@knu.ac.kr;skback@etri.re.kr; | IEEE WIRELESS COMMUNICATIONS LETTERS | IEEE WIREL COMMUN LE | 2162-2337 | 2162-2345 | 10 | 9 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2021 | 5.281 | 20.8 | 0.54 | 2025-07-30 | 7 | 8 | Link adaptation; Thompson sampling; multiarmed bandit | RATE SELECTION | Link adaptation; multiarmed bandit; Thompson sampling | Decision making; Feasibility condition; Formulated problems; High probability; Maximum through-put; Modulation and coding schemes; Multi armed bandit; On-line decision makings; Thompson samplings; Channel coding | English | 2021 | 2021-09 | 10.1109/lwc.2021.3090046 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Key Role of Microglial Matrix Metalloproteinases in Choroidal Neovascularization | Age-related macular degeneration (AMD), especially neovascular AMD with choroidal neovascularization (CNV), is the leading cause of blindness in the elderly. Although matrix metalloproteinases (MMPs) are involved in pathological ocular angiogenesis, including CNV, the cellular origin of MMPs in AMD remains unknown. The present study investigated the role of microglial MMPs in CNV. MMP activities were analyzed by gelatin zymography in aqueous humor samples from patients with CNV and laser-induced CNV mice. Active MMP-9 was increased in the aqueous humor samples from neovascular AMD patients compared with control subjects. In the retinal pigment epithelium (RPE)/choroid from CNV mice, active MMP-9 increased, beginning 1 h post-CNV induction, and remained upregulated until Day 7. In RPE/choroid from CNV mice, active MMP-9 was suppressed by minocycline, a known microglial inhibitor, at 6 h and 1-day post-CNV induction. Flow cytometry revealed that the proportion of activated microglia increased very early, beginning at 1 h post-CNV induction, and was maintained until Day 7. Similarly, immunohistochemistry revealed increased microglial activation and MMP-9 expression on CNV lesions at 6 h and 1-day post-CNV induction. SB-3CT, an MMP inhibitor, decreased vascular leakage and lesion size in laser-induced CNV mice. These findings indicated nearly immediate recruitment of activated microglia and very early MMP-9 activation in the RPE/choroid. The present study newly identified a potential role for early microglial MMP-9 expression in CNV, and furthermore that modulating microglial MMP expression is a novel putative therapeutic for CNV. | Kim, Juhee; Kim, Jong-Heon; Do, Ji Yeon; Lee, Jung Yi; Yanai, Ryoji; Lee, In-kyu; Suk, Kyoungho; Park, Dong Ho | Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; JD Bioscience Inc, R&D Ctr, Gwangju, South Korea; Yamaguchi Univ, Dept Ophthalmol, Grad Sch Med, Ube, Yamaguchi, Japan; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Ophthalmol, Daegu, South Korea | Lee, In-Kyu/AAR-6374-2021 | 59291644500; 57203324811; 57219717994; 57195563161; 7005523093; 36071537600; 7005114595; 36676632900 | dongho_park@knu.ac.kr; | FRONTIERS IN CELLULAR NEUROSCIENCE | FRONT CELL NEUROSCI | 1662-5102 | 15 | SCIE | NEUROSCIENCES | 2021 | 6.147 | 20.9 | 1.22 | 2025-07-30 | 19 | 20 | age-related macular degeneration (AMD); choroidal neovascluarization; matrix metalloproteinase; microglia; aqueous humor | MACULAR DEGENERATION; RETINAL MICROGLIA; MINOCYCLINE; ACTIVATION; MOUSE; MATRIX-METALLOPROTEINASE-9; INFLAMMATION; CONTRIBUTES; METABOLITES; EXPRESSION | age-related macular degeneration (AMD); aqueous humor; choroidal neovascluarization; matrix metalloproteinase; microglia | 2 [[(4 phenoxyphenyl)sulfonyl]methyl]thiirane; bromethol; CD11b antigen; gelatin; gelatinase A; gelatinase B; matrix metalloproteinase; minocycline; receptor type tyrosine protein phosphatase C; s1326; visual pigment; age related macular degeneration; animal cell; animal experiment; animal model; aqueous humor; Article; cataract extraction; choroid; controlled study; disease severity; flow cytometry; human; human cell; immunohistochemistry; laser-induced choroidal neovascularization; male; microglia; mouse; nonhuman; polyacrylamide gel electrophoresis; protein expression; radioimmunoprecipitation; retina fluorescein angiography; retina ganglion cell; retinal pigment epithelium; senile cataract; subretinal neovascularization; T lymphocyte activation; upregulation; Western blotting; zymography | English | 2021 | 2021-02-26 | 10.3389/fncel.2021.638098 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Neuroinflammatory Basis of Depression: Learning From Experimental Models | The neuroinflammatory basis of depression encompasses the detrimental role of otherwise supportive non-neuronal cells and neuroinflammation in hampering neuronal function, leading to depressive behavior. Animals subjected to different stress paradigms show glial cell activation and a surge in proinflammatory cytokines in various brain regions. The concept of sterile inflammation observed in animal models of depression has intrigued many researchers to determine the possible triggers of central immune cell activation. Notably, microglial activation and subsequent phenotypic polarization in depression have been strongly advocated by the wealth of recent preclinical studies; however, findings from human studies have shown contradictory results. Despite intensive investigation, many research gaps still exist to elucidate the molecular mechanisms of neuroinflammatory cascades underlying the pathophysiology of depression. In this mini-review, recent progress in understanding neuroinflammatory mechanisms in light of experimental models of depression will be thoroughly discussed. The challenges of mirroring depression in animal and in vitro models will also be highlighted. Furthermore, prospects of targeting neuroinflammation to treat depressive disorder will be covered. | Afridi, Ruqayya; Suk, Kyoungho | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea | 57200759784; 7005114595 | ksuk@knu.ac.kr; | FRONTIERS IN CELLULAR NEUROSCIENCE | FRONT CELL NEUROSCI | 1662-5102 | 15 | SCIE | NEUROSCIENCES | 2021 | 6.147 | 20.9 | 1.34 | 2025-07-30 | 55 | 56 | glia; depression; neuroinflammation; cytokines; immune cells; experimental models | FRONTAL-CORTEX; SOCIAL STRESS; DOUBLE-BLIND; SYNAPTIC PLASTICITY; MAJOR DEPRESSION; BRAIN; EXPRESSION; INFLAMMATION; ACTIVATION; PROTEIN | cytokines; depression; experimental models; glia; immune cells; neuroinflammation | CD11b antigen; chemokine receptor CX3CR1; claudin 5; corticotropin releasing factor receptor 1; cytokine; fractalkine; glucocorticoid; glucocorticoid receptor; glutamic acid; immunoglobulin enhancer binding protein; indoleamine 2,3 dioxygenase; interleukin 1; interleukin 1beta; interleukin 1beta converting enzyme; interleukin 6; ketamine; minocycline; monocyte chemotactic protein 1; n methyl dextro aspartic acid; neurotransmitter; noradrenalin; purinergic P2X7 receptor; quinolinic acid; reactive oxygen metabolite; receptor type tyrosine protein phosphatase C; tetracycline; toll like receptor 4; tumor necrosis factor; animal model; cell activation; cell proliferation; depression; disease model; gene expression; genetic polymorphism; glia cell; intestine flora; Lactobacillus; major histocompatibility complex; mass cytometry; nervous system inflammation; nonhuman; positron emission tomography; Review | English | 2021 | 2021-07-02 | 10.3389/fncel.2021.691067 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | PDK2 Deficiency Prevents Ovariectomy-Induced Bone Loss in Mice by Regulating the RANKL-NFATc1 Pathway During Osteoclastogenesis | Estrogen deficiency leads to osteoporosis as a result of an imbalance in bone remodeling due to greater bone resorption. Estrogen deficiency increases the osteoclastic resorption of bone, and many of the FDA-approved therapies for osteoporosis are antiresorptive drugs that mainly act by reducing osteoclast activity. The mitochondrial enzyme pyruvate dehydrogenase kinase (PDK) is a critical regulator of aerobic glycolysis that exerts its effects by phosphorylating the pyruvate dehydrogenase complex (PDC), which is responsible for oxidative phosphorylation. In the present study, we found that during osteoclast differentiation, PDK2 expression increased more than that of the other PDK isoenzymes. Bone loss was delayed and the number of osteoclasts was lower in ovariectomized (OVX) Pdk2(-/-) mice than in OVX wild-type mice. The differentiation of osteoclasts was suppressed in Pdk2(-/-) bone marrow-derived monocyte/macrophage lineage cells, which was associated with lower phosphorylation of cAMP response element-binding protein (CREB) and c-FOS, and a consequent reduction in NFATc1 transcription. Administration of AZD7545, a specific inhibitor of PDK2, prevented the OVX-induced bone loss and reduced the phosphorylation of CREB and c-FOS, and the protein expression of NFATc1, in osteoclasts. Collectively, these results indicate that the inhibition of PDK2 prevents osteoporosis in estrogen-deficient mice by reducing aberrant osteoclast activation, probably via inhibition of the RANKL-CREB-cFOS-NFATc1 pathway. These findings imply that PDK2 inhibitors might be repurposed for the therapy of estrogen deficiency-induced osteoporosis. (c) 2020 American Society for Bone and Mineral Research (ASBMR). | Lee, Ji-Min; Kim, Min-Ji; Lee, Sun Joo; Kim, Byung-Gyu; Choi, Je-Yong; Lee, Seung Mi; Ham, Hye Jin; Koh, Jung-Min; Jeon, Jae-Han; Lee, In-Kyu | Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Programs, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu, South Korea; Ulsan Natl Inst Sci & Technol UNIST, Inst Basic Sci IBS, Dept Biol Sci, Ctr Genom Integr CGI, Ulsan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu, South Korea; Univ Ulsan, Div Endocrinol & Metab, Asan Med Ctr, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, 807 Hoguk Ro, Daegu 41404, South Korea | Lee, In-Kyu/AAR-6374-2021; Lee, Ji Min/KCZ-2783-2024; Choi, Je-Yong/AAR-7334-2021; Kim, Min-Ji/Z-5205-2019 | 57211862625; 57206189095; 57077726900; 55797167500; 7501391068; 57192183947; 57191361390; 7201756992; 36910340400; 36071537600 | jmkoh@amc.seoul.kr;jeonjh@knu.ac.kr;leei@knu.ac.kr; | JOURNAL OF BONE AND MINERAL RESEARCH | J BONE MINER RES | 0884-0431 | 1523-4681 | 36 | 3 | SCIE | ENDOCRINOLOGY & METABOLISM | 2021 | 6.39 | 20.9 | 1.9 | 2025-07-30 | 23 | 20 | CELL SIGNALING; GENETIC ANIMAL MODEL; OSTEOCLAST; OSTEOPOROSIS; TRANSCRIPTION FACTOR | PYRUVATE-DEHYDROGENASE KINASE; KAPPA-B; MITOCHONDRIAL BIOGENESIS; RECEPTOR ACTIVATOR; DIFFERENTIATION; METABOLISM; RESORPTION; MECHANISMS; EXPRESSION; STEATOSIS | CELL SIGNALING; GENETIC ANIMAL MODEL; OSTEOCLAST; OSTEOPOROSIS; TRANSCRIPTION FACTOR | Animals; Bone Resorption; Cell Differentiation; Female; Humans; Mice; Mice, Inbred C57BL; NFATC Transcription Factors; Osteoclasts; Osteogenesis; Ovariectomy; Phosphorylation; Proto-Oncogene Proteins c-fos; RANK Ligand; azd 7545; bisphosphonic acid derivative; bone morphogenetic protein 2; bone sialoprotein; calcein; carboxy terminal telopeptide; collagen type 1; cyclic AMP responsive element binding protein; osteocalcin; osteoclast differentiation factor; protein serine threonine kinase inhibitor; pyruvate dehydrogenase kinase 2; transcription factor RUNX2; unclassified drug; NFATC1 protein, human; Nfatc1 protein, mouse; osteoclast differentiation factor; protein c fos; transcription factor NFAT; animal cell; animal experiment; animal model; Article; body mass; bone density; bone marrow derived macrophage; cell lineage; cell viability; controlled study; dual energy X ray absorptiometry; enzyme linked immunosorbent assay; female; gene expression; glycolysis; in vitro study; in vivo study; micro-computed tomography; morphometry; mouse; mRNA expression level; nonhuman; ossification; osteoblast; osteoclast; osteoclast activity; osteoclastogenesis; osteolysis; ovariectomy-induced osteoporosis; oxygen consumption rate; polyacrylamide gel electrophoresis; protein expression; protein phosphorylation; RANKL signaling; real time polymerase chain reaction; real time reverse transcription polymerase chain reaction; RNA isolation; trabecular bone; trabecular thickness; upregulation; animal; bone development; C57BL mouse; cell differentiation; human; metabolism; osteolysis; ovariectomy; phosphorylation; prevention and control | English | 2021 | 2021-03 | 10.1002/jbmr.4202 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effect of Different Cultivation Modes (Photoautotrophic, Mixotrophic, and Heterotrophic) on the Growth of Chlorella sp. and Biocompositions | In the past, biomass production using microalgae culture was dependent on inorganic carbon sources as microalgae are photosynthetic organisms. However, microalgae utilize both organic and inorganic carbon sources, such as glucose. Glucose is an excellent source of organic carbon that enhances biomass yield and the content of useful substances in microalgae. In this study, photoautotrophic, mixotrophic, and heterotrophic cultivation conditions were applied to three well-known strains of Chlorella (KNUA104, KNUA114, and KNUA122) to assess biomass productivity, and compositional changes (lipid, protein, and pigment) were evaluated in BG11 media under photoautotrophic, mixotrophic, and heterotrophic conditions utilizing different initial concentrations of glucose (5, 10, 15, 20, and 25 g L-1). Compared to the photoautotrophic condition (biomass yield: KNUA104, 0.35 +/- 0.04 g/L/d; KNUA114, 0.40 +/- 0.08 g/L/d; KNUA122, 0.38 +/- 0.05 g/L/d) glucose was absent, and the biomass yield improved in the mixotrophic (glucose: 20 g L-1; biomass yield: KNUA104, 2.99 +/- 0.10 g/L/d; KNUA114, 5.18 +/- 0.81 g/L/d; KNUA122, 5.07 +/- 0.22 g/L/d) and heterotrophic conditions (glucose: 20 g L-1; biomass yield: KNUA104, 1.72 +/- 0.26 g/L/d; KNUA114, 4.26 +/- 0.27 g/L/d; KNUA122, 4.32 +/- 0.32 g/L/d). All strains under mixotrophic and heterotrophic conditions were optimally cultured when 15-20 g L-1 initial glucose was provided. Although bioresourse productivity improved under both mixotrophic and heterotrophic conditions where mixotrophic conditions were found to be optimal as the yields of lipid and pigment were also enhanced. Protein content was less affected by the presence of light or the concentration of glucose. Under mixotrophic conditions, the highest lipid content (glucose: 15 g L-1; lipid content: 68.80 +/- 0.54%) was obtained with Chlorella vulgaris KNUA104, and enhanced pigment productivity of Chlorella sorokiniana KNUA114 and KNUA122 (additional pigment yield obtained with 15 g L-1 glucose: KNUA 114, 0.33 +/- 0.01 g L-1; KNUA122, 0.21 +/- 0.01 g L-1). Also, saturated fatty acid (SFA) content was enhanced in all strains (SFA: KNUA104, 29.76 +/- 1.31%; KNUA114, 37.01 +/- 0.98%; KNUA122, 33.37 +/- 0.17%) under mixotrophic conditions. These results suggest that mixotrophic cultivation of Chlorella vulgaris and Chlorella sorokiniana could improve biomass yield and the raw material quality of biomass. | Yun, Hyun-Sik; Kim, Young-Saeng; Yoon, Ho-Sung | Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat BioResearch Grp BK21, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Ulleung Dok, Daegu, South Korea; Kyungpook Natl Univ, Adv Bio Resource Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Dept Biol, Coll Nat Sci, Daegu, South Korea | 57215320824; 35798433500; 7402990205 | kyslhh1228@hanmail.net;hsy@knu.ac.kr; | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | FRONT BIOENG BIOTECH | 2296-4185 | 9 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 6.064 | 21.0 | 3.52 | 2025-07-30 | 57 | 70 | biomass yield; chlorella; heterotrophic; mixotrophic; photoautotrophic | ENHANCED PRODUCTION; MASS CULTIVATION; GLUCOSE; MICROALGAE; BIOMASS; VULGARIS; CARBON; QUANTIFICATION; METABOLISM; EXTRACTION | biomass yield; chlorella; heterotrophic; mixotrophic; photoautotrophic | Algae; Cultivation; Glucose; Microorganisms; Organic carbon; Productivity; Proteins; Biomass yield; Carbon source; Chlorellum; Condition; Heterotrophic; Heterotrophic conditions; Inorganic carbon; Mixotrophic; Photoautotrophic; Photoautotrophic conditions; Biomass | English | 2021 | 2021-12-17 | 10.3389/fbioe.2021.774143 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Effect of Novel Polymer-Free Nitrogen-Doped Titanium Dioxide Film-Coated Coronary Stent Loaded With Mycophenolic Acid | Background: Titanium is commonly used in blood-exposed medical devices because it has superior blood compatibility. Mycophenolic acid inhibits the proliferation of vascular smooth muscle cells. This study examined the effect of a non-polymer TiO2 thin film-coated stent with mycophenolic acid in a porcine coronary overstretch restenosis model. Methods: Thirty coronary arteries in 15 pigs were randomized into three groups in which the coronary arteries were treated with a TiO2 film-coated stent with mycophenolic acid (NTM, n = 10), everolimus-eluting stent with biodegradable polymer (EES, n = 10), or TiO2 film-coated stent (NT, n = 10). A histopathologic analysis was performed 28 days after the stenting. Results: There were no significant intergroup differences in injury score, internal elastic lamina area, or inflammation score. Percent area stenosis was significantly smaller in the NTM and EES groups than in the NT group (36.1 +/- 13.63% vs. 31.6 +/- 7.74% vs. 45.5 +/- 18.96%, respectively, p = 0.0003). Fibrin score was greater in the EES group than in the NTM and NT groups [2.0 (range, 2.0-2.0) vs. 1.0 (range, 1.0-1.75) vs. 1.0 (range, 1.0-1.0), respectively, p < 0.0001]. The in-stent occlusion rate measured by micro-computed tomography demonstrated similar percent area stenosis rates on histology analysis (36.1 +/- 15.10% in NTM vs. 31.6 +/- 8.89% in EES vs. 45.5 +/- 17.26% in NT, p < 0.05). Conclusion: The NTM more effectively reduced neointima proliferation than the NT. Moreover, the inhibitory effect of NTM on smooth muscle cell proliferation was not inferior to that of the polymer-based EES with lower fibrin deposition in this porcine coronary restenosis model. | Shim, Jae Won; Kim, Sung Soo; Kim, Hyun Kuk; Bae, In Ho; Park, Dae Sung; Park, Jun-Kyu; Kim, Jae Un; Kim, Han Byul; Lee, Min Young; Kim, Joong Sun; Kim, Jung Ha; Koo, Bon-Sang; Jeong, Kang-Jin; Kim, Sun-Uk; Kim, Min Chul; Sim, Doo Sun; Hong, Young Joon; Ahn, Youngkeun; Lim, Kyung Seob; Jeong, Myung Ho | Korea Cardiovasc Stent Res Inst, Jangsung, South Korea; Chonnam Natl Univ Hosp, Cardiovasc Res Ctr, Gwangju, South Korea; Chosun Univ Hosp, Div Cardiol, Gwangju, South Korea; Chonnam Natl Univ, Res Inst Med Sci, Gwangju, South Korea; CGBio Co Ltd, Jangsung, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu, South Korea; Chonnam Natl Univ, Coll Vet Med, Gwangju, South Korea; Korea Res Inst Biosci & Biotechnol, Futurist Anim Resource & Res Ctr, Natl Primate Res Ctr, Chungbuk, South Korea | Park, Seung-Jung/AAT-8353-2020; Hong, Young Joon/A-2792-2011; Kim, Seok-Hwan/G-9981-2015; Kim, Jong-Min/J-5435-2012; Kim, Junghwan/AAV-1973-2020; Kim, Sunuk/KJM-5211-2024; Koo, Bon-Sang/AAT-6063-2021; Kim, Ja-Eun/AAI-1896-2020 | 57202262940; 57015155300; 57206210646; 57206360685; 56656918300; 56095726200; 57210957662; 57202499822; 15119890400; 7601371367; 56657538500; 57204576307; 56181213100; 8278891100; 57202224572; 7006825347; 13310329100; 56937721300; 36470521900; 56485157500 | dvmlim96@kribb.re.kr;myungho@chollian.net; | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | FRONT BIOENG BIOTECH | 2296-4185 | 9 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 6.064 | 21.0 | 0.08 | 2025-07-30 | 1 | 1 | stents; myocophenolic acid; coronary artery; titanium coating; percutaneous coronary intervention; restenosis; inflammation | PACLITAXEL-ELUTING STENTS; SMOOTH-MUSCLE-CELLS; INTIMAL HYPERPLASIA; PROLIFERATION; RESTENOSIS; SIROLIMUS; MOFETIL; SUPPRESSION; DEPOSITION; INJURY | coronary artery; inflammation; myocophenolic acid; percutaneous coronary intervention; restenosis; stents; titanium coating | Blood; Blood vessels; Cell proliferation; Diseases; Doping (additives); Heart; Histology; Mammals; Muscle; Plastic coatings; Stents; Thin films; Titanium dioxide; Coated stents; Coronary arteries; Mycophenolic acids; Myocophenolic acid; Novel polymers; Percutaneous coronary intervention; Restenosis; Stenoses; TiO 2 films; Titania coatings; Pathology | English | 2021 | 2021-10-29 | 10.3389/fbioe.2021.650408 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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