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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Te Nanoneedles Induced Entanglement and Thermoelectric Improvement of SnSe | Chalcogenide-based materials have attracted widespread interest in high-performance thermoelectric research fields. A strategy for the application of two types of chalcogenide for improved thermoelectric performance is described herein. Tin selenide (SnSe) is used as a base material, and Te nanoneedles are crystallized in the SnSe, resulting in the generation of a composite structure of SnSe with Te nanoneedles. The thermoelectric properties with various reaction times are investigated to reveal the optimum conditions for enhanced thermoelectric performance. A reaction time of 4 h at 450 K generated a composite Te nanoneedles/SnSe sample with the maximum ZT value, 3.2 times larger than that of the pristine SnSe. This result is attributed to both the reduced thermal conductivity from the effective phonon scattering of heterointerfaces and the improved electrical conductivity value due to the introduction of Te nanoparticles. This strategy suggests an approach to generating high-performance practical thermoelectric materials. | Ju, Hyun; Kim, Myeongjin; Yang, Jinglei; Kim, Jooheon | Chung Ang Univ, Sch Chem Engn & Mat Sci, Seoul 06974, South Korea; Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, 80 Daehakro, Daegu 41566, South Korea; Hong Kong Univ Sci & Technol, Dept Mech & Aerosp Engn, Hong Kong, Peoples R China | ; Yang, Jinglei/B-1933-2008 | 56438791400; 55541419000; 10938878800; 13103271400 | mohani@cau.ac.kr;myeongjinkim@knu.ac.kr;maeyang@ust.hk;jooheonkim@cau.ac.kr; | MATERIALS | MATERIALS | 1996-1944 | 13 | 11 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2020 | 3.623 | 20.6 | 0.22 | 2025-06-25 | 2 | 5 | thermoelectric; tellurium; nanoneedles; inner-site crystallization; tin selenide | THERMAL-CONDUCTIVITY; POLYCRYSTALLINE SNSE; TRANSPORT-PROPERTIES; PERFORMANCE; NANOWIRES; NANOSTRUCTURES; NANOCOMPOSITES; NANOSHEETS | Inner-site crystallization; Nanoneedles; Tellurium; Thermoelectric; Tin selenide | Chalcogenides; Layered semiconductors; Nanoneedles; Selenium compounds; Tellurium; Thermoelectric equipment; Thermoelectricity; Electrical conductivity; Hetero-interfaces; Optimum conditions; Thermo-Electric materials; Thermoelectric performance; Thermoelectric properties; Thermoelectric research; Tin selenides; Tin compounds | English | 2020 | 2020-06 | 10.3390/ma13112523 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The Effects of Fineness and TEA-Based Chemical Admixture on Early Strength Development of Concrete in Construction Site Applications | This study examines effects of cement fineness and chemical admixtures of early strength agents on the early strength development of concrete. Three cement types were selected, namely ASTM type-I ordinary Portland cement (OPC), fineness ordinary Portland cement (FOPC), and ASTM type-III early Portland cement (EPC), and the mixing proportions of concrete were set by adding a triethanolamine-based chemical admixture to FOPC. The evaluation items considered in this study included raw material analysis, compressive strength, and maturity (D.h). The time required for the development of concrete strength of 5 MPa in the three cement types was estimated and compared. The results revealed that using FOPC enhances the strength development of concrete owing to its higher fineness and SO3 content compared to OPC. In addition, it has been observed that using both FOPC and TCA yields a similar performance to that observed using EPC, in light of the improved early strength development at low temperatures. | Lee, Taegyu; Lee, Jaehyun; Choi, Hyeonggil; Lee, Dong-Eun | Daelim Ind, Technol Res & Dev Inst, Seoul 03152, South Korea; Kyungpook Natl Univ, Sch Architecture & Civil Engn, 80 Daehakro, Bukgu 41566, Daegu, South Korea | ; Lee, Jaehyun/ABB-9148-2020 | 7501437272; 57211397021; 56430165800; 56605563300 | ninga777@naver.com;archi0528@daum.net;hgchoi@knu.ac.kr;dolee@knu.ac.kr; | MATERIALS | MATERIALS | 1996-1944 | 13 | 9 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2020 | 3.623 | 20.6 | 0.43 | 2025-06-25 | 11 | 12 | cement fineness; fine ordinary Portland cement; TEA-based chemical admixture; concrete strength; early strength development | MECHANICAL-PROPERTIES; HYDRATION KINETICS; CEMENT; EVOLUTION; IMPACT | Cement fineness; Concrete strength; Early strength development; Fine ordinary Portland cement; TEA-based chemical admixture | Compressive strength; Concrete additives; Concrete mixing; Portland cement; Tea; Triethanolamine; Chemical admixture; Concrete strength; Construction sites; Low temperatures; Material analysis; Mixing proportions; Ordinary Portland cement; Strength development; Concrete mixtures | English | 2020 | 2020-05 | 10.3390/ma13092027 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Gender difference in the impact of Ischaemic heart disease on heart failure | Background Although the impact of ischaemic heart disease (IHD) on heart failure (HF) is evolving, there is uncertainty about the role of IHD in determining the risk of clinical outcomes by gender. This study evaluated the gender difference in the impact of IHD on long-term clinical outcomes in patients with heart failure reduced ejection fraction (HFrEF). Methods Study data were obtained from a nationwide registry, which is a prospective multicentre cohort that included 3200 patients who were hospitalized for HF. A total of 1638 patients with HFrEF were classified by gender. The primary outcome was all-cause death during follow-up. Results In total, 133 women (18.9%) died and 168 men (18.0%) died during the follow-up (median, 489 days). Women with HFrEF with IHD had a significantly lower cumulative survival rate than women without IHD at the long-term follow-up (74.8% vs 84.9%, log-rank P = .001). However, the survival rate was not different in men with HFrEF with IHD compared with men without IHD. A Cox regression analysis showed that IHD had a 1.43-fold increased risk for all-cause mortality independently in women after adjusting for confounding factors (odds ratio 1.43, 95% confidence interval 1.058-1.929, P = .020). Conclusion Ischaemic heart disease was an independent risk factor for long-term mortality in women with HFrEF. IHD should be actively evaluated in women with HF for predicting clinical outcomes and initiating appropriate treatment. Women with HF caused by IHD should be treated more meticulously to avoid a poor prognosis. | Kim, Hyun-Jin; Kim, Myung-A; Kim, Hack-Lyoung; Choi, Dong-Ju; Han, Seongwoo; Jeon, Eun-Seok; Cho, Myeong-Chan; Kim, Jae-Joong; Yoo, Byung-Su; Shin, Mi-Seung; Kang, Seok-Min; Chae, Shung Chull | Hanyang Univ, Coll Med, Cardiovasc Ctr, Guri Hosp, Guri, South Korea; Seoul Natl Univ, Dept Internal Med, Boramae Med Ctr, Coll Med, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Coll Med, Seongnam, South Korea; Hallym Univ, Dongtan Sacred Heart Hosp, Dept Cardiovasc Med, Coll Med, Hwasung, South Korea; Sungkyunkwan Univ, Dept Internal Med, Samsung Med Ctr, Coll Med, Seoul, South Korea; Chungbuk Natl Univ, Dept Internal Med, Coll Med, Cheongju, South Korea; Univ Ulsan, Dept Internal Med, Asan Med Ctr, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Wonju Christian Hosp, Wonju, South Korea; Gachon Univ, Dept Internal Med, Gil Hosp, Incheon, South Korea; Yonsei Univ, Dept Internal Med, Severance Hosp, Seoul, South Korea; Kyungpook Natl Univ, Dept Internal Med, Coll Med, Daegu, South Korea | ; Jeong, Gi/AAB-2830-2021; Choi, Dong-Ju/J-5686-2012; Kim, Hyun-Jin/AAJ-2905-2021 | 57206210658; 56593722600; 17135448100; 35274349200; 55621676400; 7004279641; 7401727518; 36065764100; 7102851884; 7401536670; 7405685375; 7101962036 | kma@snu.ac.kr; | EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | EUR J CLIN INVEST | 0014-2972 | 1365-2362 | 50 | 5 | SCIE | MEDICINE, GENERAL & INTERNAL;MEDICINE, RESEARCH & EXPERIMENTAL | 2020 | 4.686 | 20.7 | 0.33 | 2025-06-25 | 4 | 4 | ejection fraction; gender; heart failure; ischaemic heart disease | RISK-FACTORS; SEX-DIFFERENCES; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; SURVIVAL; OUTCOMES; REPERFUSION; GUIDELINES; ESTROGEN; INSIGHTS | ejection fraction; gender; heart failure; ischaemic heart disease | Aged; Aged, 80 and over; Cause of Death; Comorbidity; Female; Heart Failure; Humans; Male; Middle Aged; Mortality; Myocardial Ischemia; Odds Ratio; Prognosis; Proportional Hazards Models; Registries; Republic of Korea; Sex Factors; Stroke Volume; aged; Article; clinical outcome; cohort analysis; comparative study; confidence interval; evaluation study; female; follow up; heart failure with reduced ejection fraction; hospitalization; human; ischemic heart disease; major clinical study; male; multicenter study; odds ratio; priority journal; prospective study; register; sex difference; survival rate; cause of death; comorbidity; heart failure; heart muscle ischemia; heart stroke volume; middle aged; mortality; pathophysiology; prognosis; proportional hazards model; sex factor; South Korea; very elderly | English | 2020 | 2020-05 | 10.1111/eci.13232 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Application of In Vivo Imaging Techniques for Monitoring Natural Killer Cell Migration and Tumor Infiltration | In recent years, the use of natural killer (NK) cell-based immunotherapy has shown promise against various cancer types. To some extent therapeutic potential of NK cell-based immunotherapy depends on migration of NK cells towards tumors in animal models or human subjects and subsequent infiltration. Constant improvement in the pharmacological and therapeutic properties of NK cells is driving the performance and use of NK cell-based immunotherapies. In this review, we summarize the molecular imaging techniques used in monitoring the migration and infiltration of NK cells in vivo at preclinical and clinical levels. A review of pros and cons of each molecular imaging modality is done. Finally, we provide our perception of the usefulness of molecular imaging approaches for in vivo monitoring of NK cells in preclinical and clinical scenarios. | Gangadaran, Prakash; Rajendran, Ramya Lakshmi; Ahn, Byeong-Cheol | Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Plus KNU Biomed Convergence Program BK21, Dept Biomed Sci, Sch Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Sch Med, Daegu 41944, South Korea | Gangadaran, Prakash/AAV-3102-2021; Rajendran, Ramya/AAV-6338-2021 | 54393130400; 57195318729; 7202791511 | prakashg@knu.ac.kr;ramyag@knu.ac.kr;abc2000@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 12 | 5 | SCIE | ONCOLOGY | 2020 | 6.639 | 20.9 | 0.22 | 2025-06-25 | 10 | 11 | natural killer cell; in vivo tracking; migration; infiltration; bioluminescent; MRI; SPECT; PET | NK CELLS; LINE NK-92; IMMUNOTHERAPY; CANCER; MRI; MICROENVIRONMENT; TRACKING; MICE; PET | Bioluminescent; In vivo tracking; Infiltration; Migration; MRI; Natural killer cell; PET; SPECT | cell expansion; cell labeling; cell migration; cell therapy; computer assisted tomography; fluorescence imaging; human; immune system; in vivo study; lymphocytic infiltration; molecular imaging; natural killer cell; non invasive procedure; nonhuman; nuclear magnetic resonance imaging; process development; Review; risk benefit analysis | English | 2020 | 2020-05 | 10.3390/cancers12051318 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparison of Dose Distribution in Regional Lymph Nodes in Whole-Breast Radiotherapy vs. Whole-Breast Plus Regional Lymph Node Irradiation: An In Silico Planning Study in Participating Institutions of the Phase III Randomized Trial (KROG 1701) | Simple Summary The purpose of the current in silico planning study is to compare radiation doses of whole-breast irradiation (WBI) and whole-breast plus regional lymph node irradiation (WBI+RNI) administered to the regional lymph nodes (RLN) in pN1 breast cancer. Twenty-four participating institutions were asked to create plans of WBI and WBI+RNI for two dummy cases. In all RLN regions including supraclavicular lymph node, axillary lymph node, and internal mammary lymph node, the radiation dose to the RLN was higher in WBI+RNI plan than WBI plan. The purpose of the current in silico planning study is to compare radiation doses of whole-breast irradiation (WBI) and whole-breast plus regional lymph node irradiation (WBI+RNI) administered to the regional lymph nodes (RLN) in pN1 breast cancer. Twenty-four participating institutions were asked to create plans of WBI and WBI+RNI for two dummy cases. To compare target coverage between the participants, an isodose line equal to 90% of the prescribed dose was converted to an isodose contour (contour(90% iso))(.) The relative nodal dose (RND) was obtained using the ratio of RLN dose to the target dose. The Fleiss's kappa values which represent inter-observer agreement of contour(90% iso) were over 0.68. For RNI, 6 institutions included axillary lymph node (ALN), supraclavicular lymph node (SCN), and internal mammary lymph node (IMN), while 18 hospitals included only ALN and SCN. The median RND between the WBI and WBI+RNI were as follows: 0.64 vs. 1.05 (ALN level I), 0.27 vs. 1.08 (ALN level II), 0.02 vs. 1.12 (ALN level III), 0.01 vs. 1.12 (SCN), and 0.54 vs. 0.82 (IMN). In all nodal regions, the RND was significantly lower in WBI than in WBI+RNI (p < 0.01). In this study, we could identify the nodal dose difference between WBI and WBI+RNI. | Kim, Haeyoung; Kim, Heejung; Park, Won; Baek, Jong Yun; Ahn, Sung Ja; Kim, Mi Young; Park, Shin-Hyung; Lee, Ik Jae; Ha, Inbong; Kim, Jin Hee; Kim, Tae Hyun; Lee, Kyu Chan; Lee, Hyung-Sik; Kim, Tae Gyu; Kim, Jin Ho; Lee, Jong Hoon; Jung, Jinhong; Cho, Oyeon; Chang, Jee Suk; Kim, Eun Seog; Jo, In Young; Koo, Taeryool; Kim, Kyubo; Park, Hae Jin; Shin, Young-Joo; Ha, Boram; Kwon, Jeanny; Lee, Ju Hye; Moon, Sunrock | Sungkyunkwan Univ, Dept Radiat Oncol, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea; Chonnam Natl Univ, Dept Radiat Oncol, Sch Med, Gwangju 58128, South Korea; Kyungpook Natl Univ, Dept Radiat Oncol, Chilgok Hosp, Daegu 41404, South Korea; Kyungpook Natl Univ, Dept Radiat Oncol, Sch Med, Daegu 41944, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Radiat Oncol, Coll Med, Seoul 06273, South Korea; Gyengsang Natl Univ, Dept Radiat Oncol, Gyengsang Natl Univ Hosp, Sch Med, Jinju 52727, South Korea; Keimyung Univ, Dept Radiat Oncol, Dongsan Med Ctr, Sch Med, Daegu 41931, South Korea; Ctr Proton Therapy, Res Inst & Hosp, Natl Canc Ctr, Goyang 10408, South Korea; Gachon Univ, Dept Radiat Oncol, Gil Med Ctr, Coll Med, Incheon 21565, South Korea; Dong A Univ, Dept Radiat Oncol, Dong A Univ Hosp, Sch Med, Busan 49201, South Korea; Sungkyunkwan Univ, Dept Radiat Oncol, Samsung Changwon Hosp, Sch Med, Chang Won 51353, South Korea; Seoul Natl Univ Hosp, Dept Radiat Oncol, Seoul 03080, South Korea; Catholic Univ Korea, St Vincents Hosp, Dept Radiat Oncol, Suwon 16247, South Korea; Univ Ulsan, Dept Radiat Oncol, Asan Med Ctr, Coll Med, Seoul 05505, South Korea; Ajou Univ, Dept Radiat Oncol, Sch Med, Suwon 16499, South Korea; Yonsei Univ, Dept Radiat Oncol, Yonsei Canc Ctr, Coll Med, Seoul 03722, South Korea; Soonchunhyang Univ, Dept Radiat Oncol, Soonchunhyang Univ Hosp, Coll Med, Cheonan 31151, South Korea; Hallym Univ, Dept Radiat Oncol, Sacred Heart Hosp, Coll Med, Anyang 14068, South Korea; Ewha Womans Univ, Dept Radiat Oncol, Coll Med, Seoul 07804, South Korea; Hanyang Univ, Dept Radiat Oncol, Coll Med, Seoul 15588, South Korea; Inje Univ, Dept Radiat Oncol, Sanggye Paik Hosp, Seoul 07804, South Korea; Hallylm Univ, Dept Radiat Oncol, Dongtan Sacred Heart Hosp, Hwaseong 14068, South Korea; Chungnam Natl Univ Hosp, Dept Radiat Oncol, Daejeon 35015, South Korea; Pusan Natl Univ, Dept Radiat Oncol, Yangsan Hosp, Yangsan 50612, South Korea; Wonkwang Univ, Dept Radiat Oncol, Wonkwang Univ Hosp, Sch Med, Iksan 54538, South Korea | LEE, HYUN/ABC-6119-2021; Kim, Seung/N-5248-2019; Kim, Ho Jin/IZP-7210-2023; Lee, Heejin/HTT-4810-2023; Chang, Jee Suk/ABU-3301-2022; Kim, Haeyoung/ABC-4815-2020; lee, sang/Q-4650-2019; Kim, Jae-Young/IUO-6466-2023; Park, Shinhyung/LNQ-6428-2024; Kim, Tae/P-1470-2019; Kim, Kyubo/R-8061-2019; Kim, Yoon/J-2746-2012 | 56007004100; 57210863444; 55663053400; 57210117184; 57211944596; 57204652164; 57203275843; 36786568600; 55446184300; 56441016600; 59326720300; 38163172100; 36071723900; 55696487300; 56723658800; 56558022100; 55855898600; 55657921200; 57191191340; 55261521700; 55558794700; 55598457600; 8213302900; 57201025307; 57114085500; 56022514500; 55888496100; 55648203200; 7401616455 | kim@samsung.com;heejung0228.kim@samsung.com;wonro.park@samsung.com;jy2.baek@samsung.com;ahnsja@chonnam.ac.kr;cucici912@gmail.com;shinhyungpark@knu.ac.kr;ikjae412@yuhs.ac;nicehib@gnuh.co.kr;jhkim@dsmc.or.kr;k2onco@ncc.re.kr;kyu22@gilhospital.com;hyslee@dau.ac.kr;ktg7757@hanmail.net;jinhokim@snuh.org;koppul@catholic.ac.kr;jung.jinhong@amc.seoul.kr;oyeoncho@aumc.ac.kr;changjeesuk@yuhs.ac;inyoung.jo@schmc.ac.kr;kootaeryool@hallym.or.kr;kyubokim@ewha.ac.kr;haejinpark@hanyang.ac.kr;fluty99@empal.com;boramhaa@hallym.or.kr;ijeannyi@daum.net;gg220110@goodhospital.or.kr;sunrmoon@wku.ac.kr; | CANCERS | CANCERS | 2072-6694 | 12 | 11 | SCIE | ONCOLOGY | 2020 | 6.639 | 20.9 | 0.13 | 2025-06-25 | 2 | 3 | breast cancer; lymph nodes; radiotherapy planning; randomized trial | INTERNAL MAMMARY; DUMMY RUN; CANCER; DELINEATION; AGREEMENT; IMPACT | Breast cancer; Lymph nodes; Radiotherapy planning; Randomized trial | Article; axillary lymph node; breast cancer; cancer patient; cancer radiotherapy; comparative study; computer analysis; controlled study; hospital; human; intensity modulated radiation therapy; internal mammary lymph node; lymph node; phase 3 clinical trial; prescription; radiation dose; radiation dose distribution; radiotherapy planning; randomized controlled trial; supraclavicular lymph node; three dimensional conformal radiotherapy; treatment planning; whole breast radiotherapy | English | 2020 | 2020-11 | 10.3390/cancers12113261 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3β Activation in Cancer Cells | Simple Summary Dexamethasone (DEX) is commonly used as immunosuppressive and chemotherapeutic agent. The effects of DEX on cell death is different, depending on cell types and stimuli. Here, we found that DEX inhibited tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell death in cancer cells. Upregulation of c-FLIP(L) and downregulation of death receptor 5 (DR5) play a critical role in anti-apoptotic effects of DEX in TRAIL-induced apoptosis. DEX upregulated c-FLIP(L) expression at the transcriptional levels through the GSK-3 beta signaling pathway. Furthermore, DEX also modulated protein stability of DR5 via the GSK-3 beta/Cbl axis-mediated ubiquitin-proteasome system. Therefore, DEX-induced GSK3 beta activation plays a critical role in the modulation of c-FLIP(L) and DR5. This finding suggests that DEX reduced effects of anti-cancer drugs in cancer cells. Dexamethasone (DEX), a synthetic glucocorticoid, is commonly used as immunosuppressive and chemotherapeutic agent. This study was undertaken to investigate the effects of DEX on the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in cancer cells. We found that upregulation of c-FLIP(L) and downregulation of death receptor 5 (DR5; receptor for TRAIL ligand) contribute to the anti-apoptotic effect of DEX on TRAIL-induced apoptosis. DEX increased c-FLIP(L) expression at the transcriptional levels through the GSK-3 beta signaling pathway. The pharmacological inhibitor and catalytic mutant of GSK-3 beta suppressed DEX-induced upregulation of c-FLIP(L) expression. Furthermore, GSK-3 beta specific inhibitor markedly abolished DEX-mediated reduction of TRAIL-induced apoptosis in human renal cancer cells (Caki-1 and A498), human lung cancer cells (A549), and human breast cancer cells (MDA-MB361). In addition, DEX decreased protein stability of DR5 via GSK-3 beta-mediated upregulation of Cbl, an E3 ligase of DR5. Knockdown of Cbl by siRNA markedly inhibited DEX-induced DR5 downregulation. Taken together, these results suggest that DEX inhibits TRAIL-mediated apoptosis via GSK-3 beta-mediated DR5 downregulation and c-FLIP(L) upregulation in cancer cells. | Jeon, Mi-Yeon; Woo, Seon Min; Seo, Seung Un; Kim, Sang Hyun; Nam, Ju-Ock; Kim, Shin; Park, Jong-Wook; Kubatka, Peter; Min, Kyoung-jin; Kwon, Taeg Kyu | Keimyung Univ, Sch Med, Dept Immunol, Daegu 42601, South Korea; Kyungpook Natl Univ, Dept Pharmacol, Sch Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Comenius Univ, Dept Med Biol, Jessenius Fac Med, Bratislava 03601, Martin, Slovakia; Comenius Univ, Dept Expt Carcinogenesis, Div Oncol, Biomed Ctr Martin,Jessenius Fac Med, Bratislava 03601, Martin, Slovakia; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea; Keimyung Univ, Ctr Forens Pharmaceut Sci, Daegu 42601, South Korea | Park, Jung Hwan/AAA-1951-2022; Kim, Shin/D-1669-2013 | 57198431899; 57199873466; 57195411399; 57210450420; 7201496105; 57210866288; 55717085400; 6602546119; 7201466928; 7202206057 | dldkfls2333@naver.com;406705@kmu.ac.kr;407087@kmu.ac.kr;shkim72@knu.ac.kr;namjo@knu.ac.kr;god98005@dsmc.or.kr;j303nih@dsmc.or.kr;peter.kubatka@uniba.sk;kjmin@dgmif.re.kr;kwontk@dsmc.or.kr; | CANCERS | CANCERS | 2072-6694 | 12 | 10 | SCIE | ONCOLOGY | 2020 | 6.639 | 20.9 | 0.47 | 2025-06-25 | 9 | 9 | dexamethasone; TRAIL; DR5; c-FLIP(L); apoptosis; GSK-3β | AUDITORY HAIR-CELLS; MEDIATED APOPTOSIS; C-FLIP; DEATH; EXPRESSION; RECEPTOR; PROTECTS; AUTOPHAGY; LIGAND; CBL | c-FLIP(L), apoptosis; Dexamethasone; DR5; GSK-3β; TRAIL | death receptor 5; dexamethasone; FLICE inhibitory protein; glycogen synthase kinase 3beta; tumor necrosis factor related apoptosis inducing ligand; antineoplastic activity; apoptosis; Article; breast cancer cell line; controlled study; down regulation; drug mechanism; human; human cell; lung cancer cell line; protein expression; protein stability; renal cancer cell line; upregulation | English | 2020 | 2020-10 | 10.3390/cancers12102901 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Does the Use of Proton Pump Inhibitors Increase the Risk of Pancreatic Cancer? A Systematic Review and Meta-Analysis of Epidemiologic Studies | Background: One of the most frequently used medications for treating gastrointestinal disorders is proton pump inhibitor (PPI), which reportedly has potential adverse effects. Although the relationship between the use of PPIs and the risk of pancreatic cancer has been extensively investigated, the results remain inconsistent. Hence, this meta-analysis aimed to evaluate such relationship. Methods: We searched for literature and subsequently included 10 studies (seven case-control and three cohort studies; 948,782 individuals). The pooled odds ratio (OR) and 95% confidence intervals (CI) for pancreatic cancer were estimated using a random-effects model. We also conducted sensitivity analysis and subgroup analysis. Results: The pooled OR of the meta-analysis was 1.698 (95% CI: 1.200-2.402, p = 0.003), with a substantial heterogeneity (I-2 = 98.75%, p < 0.001). Even when studies were excluded one by one, the pooled OR remained statistically significant. According to the stratified subgroup analyses, PPI use, and pancreatic cancer incidence were positively associated, regardless of the study design, quality of study, country, and PPI type. Conclusion: PPI use may be associated with the increased risk of pancreatic cancer. Hence, caution is needed when using PPIs among patients with a high risk of pancreatic cancer. | Hong, Hee-Eun; Kim, A-Sol; Kim, Mi-Rae; Ko, Hae-Jin; Jung, Min Kyu | Kyungpook Natl Univ Hosp, Dept Family Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Family Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Family Med, Chilgok Hosp, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Div Gastroenterol, Dept Internal Med, Daegu 41944, South Korea | 57218525734; 57203290656; 57218324485; 54393415700; 56783168100 | hhe8824@naver.com;deepai@knu.ac.kr;jmrtm@daum.net;liveforme@knu.ac.kr;minky1973@hanmail.net; | CANCERS | CANCERS | 2072-6694 | 12 | 8 | SCIE | ONCOLOGY | 2020 | 6.639 | 20.9 | 0.94 | 2025-06-25 | 16 | 16 | proton pump inhibitor; pancreatic cancer; pancreatic neoplasm; meta-analysis | N-NITROSO COMPOUNDS; RECEPTOR ANTAGONIST USE; HEPATOCELLULAR-CARCINOMA; ACID SUPPRESSION; INTRAGASTRIC PH; GASTRIC-CANCER; INFECTION; ETIOLOGY; NITRITE; MEAT | Meta-analysis; Pancreatic cancer; Pancreatic neoplasm; Proton pump inhibitor | esomeprazole; lansoprazole; omeprazole; pantoprazole; proton pump inhibitor; rabeprazole; Article; cancer incidence; cancer risk; drug use; human; meta analysis; pancreas cancer; sensitivity analysis; systematic review | English | 2020 | 2020-08 | 10.3390/cancers12082220 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Dynamics of Fecal Microbiota with and without Invasive Cervical Cancer and Its Application in Early Diagnosis | Simple Summary The fecal microbiome has been suggested to be linked to invasive cervical cancer (ICC). Considering that ICC is common in women, it is important to identify bacterial signatures from fecal microbiota that contribute in classifying cervical cancer. Although previous studies have suggested possible biomarkers based on fecal microbiota, limited information exists in terms of the diagnostic ability using gut microbiota-derived signatures for detecting early ICC. The purpose of this study was to investigate the potential association between early ICC and fecal microbiota and to examine whether fecal microbiota-derived markers can be utilized as a non-invasive tool to diagnose early ICC using machine learning (ML) techniques. Further studies to incorporate quantitative and qualitative characterization of identified individual bacterial genus and validate our model in larger cohorts are imperative in terms of causality for the association between cervical cancer and microbes. The fecal microbiota is being increasingly implicated in the diagnosis of various diseases. However, evidence on changes in the fecal microbiota in invasive cervical cancer (ICC) remains scarce. Here, we aimed to investigate the fecal microbiota of our cohorts, develop a diagnostic model for predicting early ICC, and identify potential fecal microbiota-derived biomarkers using amplicon sequencing data. We obtained fecal samples from 29 healthy women (HC) and 17 women with clinically confirmed early ICC (CAN). Although Shannon's diversity index was not reached at statistical significance, the Chao1 and Observed operational taxonomic units (OTUs) in fecal microbiota was significantly different between CAN and HC group. Furthermore, there were significant differences in the taxonomic profiles between HC and CAN; Prevotella was significantly more abundant in the CAN group and Clostridium in the HC group. Linear discriminant analysis effect size (LEfSe) analysis was applied to validate the taxonomic differences at the genus level. Furthermore, we identified a set of seven bacterial genera that were used to construct a machine learning (ML)-based classifier model to distinguish CAN from patients with HC. The model had high diagnostic utility (area under the curve [AUC] = 0.913) for predicting early ICC. Our study provides an initial step toward exploring the fecal microbiota and helps clinicians diagnose. | Kang, Gi-Ung; Jung, Da-Ryung; Lee, Yoon Hee; Jeon, Se Young; Han, Hyung Soo; Chong, Gun Oh; Shin, Jae-Ho | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41404, South Korea; Kyungpook Natl Univ, Dept Obstet & Gynecol, Chilgok Hosp, Daegu 41404, South Korea; Kyungpook Natl Univ, Clin Omics Res Ctr, Sch Med, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu 41405, South Korea | 57211635810; 57221116102; 37088851700; 57216296837; 7401969388; 23099068000; 57224125922 | gukang@knu.ac.kr;amugae1210@knu.ac.kr;mylyh3@naver.com;tpqkf0927@naver.com;hshan@knu.ac.kr;gochong@knu.ac.kr;jhshin@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 12 | 12 | SCIE | ONCOLOGY | 2020 | 6.639 | 20.9 | 0.88 | 2025-06-25 | 29 | 31 | machine learning; gut microbiome; vaginal microbiome; prediction | GUT MICROBIOTA; ASSOCIATION; BACTERIA; BUTYRATE | Gut microbiome; Machine learning; Prediction; Vaginal microbiome | tumor marker; adult; amplicon; area under the curve; Article; bacterium identification; classifier; clinical article; Clostridium; cohort analysis; controlled study; diagnostic value; discriminant analysis; early diagnosis; effect size; feces analysis; feces microflora; female; Finegoldia; genus; human; invasive cervical cancer; machine learning; microbial population dynamics; nonhuman; Peptostreptococcus; population abundance; predictive value; Prevotella; Pseudomonas; Ruminococcus; sequence analysis; taxonomic identification; uterine cervix cancer | English | 2020 | 2020-12 | 10.3390/cancers12123800 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects of message framing and health literacy on intention to perform diabetes self-care: A randomized controlled trial | Aims: To evaluate the effect of positive and negative message framing in diabetes education on attitudes, perceived control, and behavioral intentions toward diabetes self-care, and to identify potential moderating effects of health literacy on message framing. Methods: A total of 52 patients with type 2 diabetes that visited an ambulatory endocrinology wing at a university hospital in Korea were randomized into positive or negative message framing groups. Each group watched a 10-minute video that was either positively or negatively framed, accentuating desirable outcomes from good diabetes self-care in the former and undesirable outcomes from inadequate diabetes self-care in the latter. Two-way ANCOVA controlling for HbA1C was conducted to evaluate outcomes. Results: Patients who watched the negatively framed message showed significantly more favorable attitudes and perceived control toward diabetes self-care than those who viewed the positively framed message. Message framing had significant indirect effects on behavioral intentions for diabetes self-care that were mediated by attitudes and perceived control. Conversely, no significant interaction effects were observed between health literacy level and message framing of these same markers. Conclusion: The use of negative message framing in diabetes education is a promising strategy for shaping favorable attitudes, beliefs, and intentions toward diabetes self-care behavior. (C) 2020 Elsevier B.V. All rights reserved. | Park, Jihyun; Kim, Su Hyun; Kim, Jung Guk | Kyungpook Natl Univ, Coll Nursing, Res Inst Nursing Sci, 680 Gukchaebosang Ro, Daegu 700422, South Korea; Kyungpook Natl Univ, Dept Endocrinol, Med Ctr, Daegu, South Korea | kim, su/AAK-6271-2021 | 57210600244; 56664542600; 16506485900 | suhyun_kim@knu.ac.kr; | DIABETES RESEARCH AND CLINICAL PRACTICE | DIABETES RES CLIN PR | 0168-8227 | 1872-8227 | 161 | SCIE | ENDOCRINOLOGY & METABOLISM | 2020 | 5.602 | 20.9 | 0.68 | 2025-06-25 | 23 | 18 | Health attitudes; Diabetes mellitus; Health education; Health literacy; Self-care | LOSS-FRAMED MESSAGES; RELATIVE PERSUASIVENESS; BEHAVIOR; SMOKING; RISK | Diabetes mellitus; Health attitudes; Health education; Health literacy; Self-care | Aged; Diabetes Mellitus, Type 2; Female; Health Education; Health Literacy; Health Promotion; Humans; Intention; Male; Self Care; hemoglobin A1c; adult; aged; Article; attitude to health; controlled study; diabetes control; diabetes education; diabetes mellitus; disease duration; educational status; female; health literacy; health promotion; human; low risk patient; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; patient attitude; randomized controlled trial; risk reduction; self care; South Korea; behavior; health education; health literacy; non insulin dependent diabetes mellitus; procedures; self care | English | 2020 | 2020-03 | 10.1016/j.diabres.2020.108043 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Epigenetic Associations between lncRNA/circRNA and miRNA in Hepatocellular Carcinoma | Simple Summary Non-coding RNAs such as microRNAs, long non-coding RNAs, and circular RNAs contribute to the development and progression of hepatocellular carcinoma through epigenetic association. Long non-coding RNAs and circular RNAs act as competing endogenous RNAs that contain binding sites for miRNAs and thus compete with the miRNAs, which results in promotion of miRNA target gene expression, thereby leading to proliferation and metastasis of hepatocellular carcinoma. Competing endogenous RNAs have the potential to become diagnostic biomarkers and therapeutic targets for treatment of hepatocellular carcinoma. The three major members of non-coding RNAs (ncRNAs), named microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play an important role in hepatocellular carcinoma (HCC) development. Recently, the competing endogenous RNA (ceRNA) regulation model described lncRNA/circRNA as a sponge for miRNAs to indirectly regulate miRNA downstream target genes. Accumulating evidence has indicated that ceRNA regulatory networks are associated with biological processes in HCC, including cancer cell growth, epithelial to mesenchymal transition (EMT), metastasis, and chemoresistance. In this review, we summarize recent discoveries, which are specific ceRNA regulatory networks (lncRNA/circRNA-miRNA-mRNA) in HCC and discuss their clinical significance. | Han, Tae-Su; Hur, Keun; Cho, Hyun-Soo; Ban, Hyun Seung | Korea Res Inst Biosci & Biotechnol KRIBB, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea | Hur, Keun/G-9513-2011; Ban, Hyun Seung/F-9526-2014; Ban, Hyun/F-9526-2014 | 26424339800; 8861888000; 56508722000; 56583720900 | tshan@kribb.re.kr;KeunHur@knu.ac.kr;chohs@kribb.re.kr;banhs@kribb.re.kr; | CANCERS | CANCERS | 2072-6694 | 12 | 9 | SCIE | ONCOLOGY | 2020 | 6.639 | 20.9 | 3.25 | 2025-06-25 | 143 | 135 | microRNA; long non-coding RNA; circular RNA; competing endogenous RNA; hepatocellular carcinoma | LONG NONCODING RNA; COMPETING ENDOGENOUS RNA; CIRCULAR RNA; LIVER-CANCER; EXPRESSION PROFILES; CELL-PROLIFERATION; MOLECULAR SPONGE; DOWN-REGULATION; HEPATITIS-B; PROMOTES | Circular RNA; Competing endogenous RNA; Hepatocellular carcinoma; Long non-coding RNA; MicroRNA | circular ribonucleic acid; long untranslated RNA; microRNA; microRNA 138; microRNA 144; microRNA 145; microRNA 146b 5p; microRNA 149 5p; microRNA 181a 5p; microRNA 184; microRNA 199a; microRNA 199b 5p; microRNA 204; microRNA 206; microRNA 214 5p; microRNA 216b; microRNA 22 3p; microRNA 26a; microRNA 26b; microRNA 30a 5p; microRNA 326; microRNA 330 5p; microRNA 365; microRNA 4443; microRNA 485 5p; microRNA 490 3p; microRNA 513c; microRNA 520c 3p; microRNA 520d 3p; unclassified drug; cancer growth; carcinogenesis; cell invasion; cell migration; cell proliferation; epigenetics; epithelial mesenchymal transition; gene control; gene function; gene targeting; genetic association; human; liver cell carcinoma; nonhuman; Review; signal transduction; tumor suppressor gene | English | 2020 | 2020-09 | 10.3390/cancers12092622 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | G1 Cell Cycle Arrest and Extrinsic Apoptotic Mechanisms Underlying the Anti-Leukemic Activity of CDK7 Inhibitor BS-181 | Simple Summary Chemotherapy resistance in human T-cell acute lymphoblastic leukemia (T-ALL), an aggressive neoplasm, results in poor prognosis despite advances in treatment modalities. Toward the identification of an effective alternative, in the present study, we elucidated the mechanism underlying the antitumor activity of the CDK7 inhibitor BS-181 using malignant cells (Jurkat A3, U937, and HeLa) and normal human peripheral T cells. This is the first report to demonstrate that BS-181 antitumor activity is mainly caused by extrinsic apoptosis induction through cell-surface TRAIL/DR5 levels in human T-ALL Jurkat T cells. Moreover, combined treatment with recombinant TRAIL (rTRAIL) exerted synergistic effects on BS-181 cytotoxicity against malignant cells but not normal human peripheral T cells by augmenting both the extrinsic and intrinsic BCL-2-sensitive apoptosis pathways. Our findings suggest that the combination with rTRAIL may facilitate BS-181 antitumor activity against T-ALL cells while minimizing associated side effects, therefore potentially being applicable to clinical human T-ALL treatment. In vitro antitumor activity of the CDK7 inhibitor BS-181 against human T-ALL Jurkat cells was determined. Treatment of Jurkat clones (JT/Neo) with BS-181 caused cytotoxicity and several apoptotic events, including TRAIL/DR4/DR5 upregulation, c-FLIP down-regulation, BID cleavage, BAK activation, Delta psi(m) loss, caspase-8/9/3 activation, and PARP cleavage. However, the BCL-2-overexpressing Jurkat clone (JT/BCL-2) abrogated these apoptotic responses. CDK7 catalyzed the activating phosphorylation of CDK1 (Thr161) and CDK2 (Thr160), and CDK-directed retinoblastoma phosphorylation was attenuated in both BS-181-treated Jurkat clones, whereas only JT/BCL-2 cells exhibited G(1) cell cycle arrest. The G(1)-blocker hydroxyurea augmented BS-181-induced apoptosis by enhancing TRAIL/DR4/DR5 upregulation and c-FLIP down-regulation. BS-181-induced FITC-annexin V-positive apoptotic cells were mostly in the sub-G(1) and G(1) phases. BS-181-induced cytotoxicity and mitochondrial apoptotic events (BAK activation/Delta psi(m) loss/caspase-9 activation) in Jurkat clones I2.1 (FADD-deficient) and I9.2 (caspase-8-deficient) were significantly lower than in A3 (wild-type). Exogenously added recombinant TRAIL (rTRAIL) markedly synergized BS-181-induced apoptosis in A3 cells but not in normal peripheral T cells. The cotreatment cytotoxicity was significantly reduced by the DR5-blocking antibody but not by the DR4-blocking antibody. These results demonstrated that the BS-181 anti-leukemic activity is attributed to extrinsic TRAIL/DR5-dependent apoptosis preferentially induced in G(1)-arrested cells, and that BS-181 and rTRAIL in combination may hold promise for T-ALL treatment. | Park, Shin Young; Kim, Ki Yun; Jun, Do Youn; Hwang, Su-Kyeong; Kim, Young Ho | Kyungpook Natl Univ, Sch Life Sci, Lab Immunobiol, Four KNU Creat BioRes Grp BK21, Daegu 41566, South Korea; Kyungpook Natl Univ, Astrogen Inc, Technobldg 313, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu 41566, South Korea | 57210165477; 57189898278; 19134667600; 37761570400; 57208312159 | psy0419@knu.ac.kr;kky@knu.ac.kr;dyjun@knu.ac.kr;skhwang@knu.ac.kr;ykim@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 12 | 12 | SCIE | ONCOLOGY | 2020 | 6.639 | 20.9 | 0.67 | 2025-06-25 | 12 | 13 | CDK inhibitor; G(1) arrest; extrinsic apoptotic pathway; TRAIL; DR5; leukemia | ACUTE LYMPHOBLASTIC-LEUKEMIA; DEPENDENT KINASES; MITOCHONDRIAL APOPTOSIS; PROMETAPHASE ARREST; PROTEIN-KINASE; CANCER; PHOSPHORYLATION; ACTIVATION; PATHWAY; LIGAND | CDK inhibitor; DR5; Extrinsic apoptotic pathway; G<sub>1</sub> arrest; Leukemia; TRAIL | bs 181; caspase 3; caspase 8; caspase 9; cyclin dependent kinase 1; cyclin dependent kinase 2; cyclin dependent kinase 7; death receptor 4; death receptor 5; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; protein Bak; protein serine threonine kinase inhibitor; tumor necrosis factor related apoptosis inducing ligand; unclassified drug; antileukemic activity; apoptosis; Article; controlled study; cytotoxicity; down regulation; drug mechanism; enzyme activation; G1 phase cell cycle checkpoint; human; human cell; Jurkat cell line; protein cleavage; protein phosphorylation; upregulation | English | 2020 | 2020-12 | 10.3390/cancers12123845 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Machine Learning Model to Predict Pseudoprogression Versus Progression in Glioblastoma Using MRI: A Multi-Institutional Study (KROG 18-07) | Simple Summary Even after the introduction of a standard regimen consisting of concurrent chemoradiotherapy and adjuvant temozolomide, patients with glioblastoma multiforme mostly experience disease progression. Clinicians often encounter a situation where they need to distinguish progressive disease from pseudoprogression after treatment. We tried to investigate the feasibility of machine learning algorithm to distinguish pseudoprogression from progressive disease. In multi-institutional dataset, the developed machine learning model showed an acceptable performance. This algorithm involving MRI data and clinical features could help making decision during patients' disease course. For the practical use, we calibrated the machine learning model to offer the probability of pseudoprogression to clinicians, then we constructed the web-based user interface to access the model. Some patients with glioblastoma show a worsening presentation in imaging after concurrent chemoradiation, even when they receive gross total resection. Previously, we showed the feasibility of a machine learning model to predict pseudoprogression (PsPD) versus progressive disease (PD) in glioblastoma patients. The previous model was based on the dataset from two institutions (termed as the Seoul National University Hospital (SNUH) dataset,N= 78). To test this model in a larger dataset, we collected cases from multiple institutions that raised the problem of PsPD vs. PD diagnosis in clinics (Korean Radiation Oncology Group (KROG) dataset,N= 104). The dataset was composed of brain MR images and clinical information. We tested the previous model in the KROG dataset; however, that model showed limited performance. After hyperparameter optimization, we developed a deep learning model based on the whole dataset (N= 182). The 10-fold cross validation revealed that the micro-average area under the precision-recall curve (AUPRC) was 0.86. The calibration model was constructed to estimate the interpretable probability directly from the model output. After calibration, the final model offers clinical probability in a web-user interface. | Jang, Bum-Sup; Park, Andrew J.; Jeon, Seung Hyuck; Kim, Il Han; Lim, Do Hoon; Park, Shin-Hyung; Lee, Ju Hye; Chang, Ji Hyun; Cho, Kwan Ho; Kim, Jin Hee; Sunwoo, Leonard; Choi, Seung Hong; Kim, In Ah | Seoul Natl Univ, Dept Radiat Oncol, Bundang Hosp, Seongnam 13620, South Korea; SELVAS AI Inc, Artificial Intelligence Res & Dev Lab, Seoul 08594, South Korea; Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon 34141, South Korea; Seoul Natl Univ Hosp, Dept Radiat Oncol, Seoul 03080, South Korea; Sungkyunkwan Univ, Dept Radiat Oncol, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu 41944, South Korea; Pusan Natl Univ Hosp, Dept Radiat Oncol, Busan 49241, South Korea; Natl Canc Ctr, Proton Therapy Ctr, Res Inst & Hosp, Goyang 10408, South Korea; Keimyung Univ, Dept Radiat Oncol, Dongsan Med Ctr, Sch Med, Daegu 42601, South Korea; Seoul Natl Univ, Dept Radiol, Bundang Hosp, Seongnam 13620, South Korea; Seoul Natl Univ Hosp, Dept Radiol, Seoul 03080, South Korea; Seoul Natl Univ, Dept Radiat Oncol, Canc Res Inst, Seoul 03080, South Korea; Seoul Natl Univ, BK21 Four Smart Healthcare, Coll Med, Seoul 03080, South Korea | ; Cho, Hwa Jin/AFA-1420-2022; Kim, Hee/F-4594-2014; Kim, In/J-5426-2012; Park, Shinhyung/LNQ-6428-2024 | 57193517333; 57207829767; 57192673009; 55559560100; 7401816010; 57203275843; 55689931500; 43860954900; 56507757300; 56441016600; 55570169000; 36068182300; 35210493700 | bigwiz83@gmail.com;parkukkyu@daum.net;hyck9004@naver.com;ihkim@snu.ac.kr;dh8lim@skku.edu;shinhyungpark@knu.ac.kr;drleejuhye@gmail.com;jh.chang@snu.ac.kr;kwancho@ncc.re.kr;jhkim@dsmc.or.kr;leonard.sunwoo@gmail.com;verocay1@snu.ac.kr;inah228@snu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 12 | 9 | SCIE | ONCOLOGY | 2020 | 6.639 | 20.9 | 1.15 | 2025-06-25 | 22 | 25 | machine learning; glioblastoma; radiotherapy; pseudoprogression | MGMT PROMOTER METHYLATION; HIGH-GRADE GLIOMAS; ADJUVANT TEMOZOLOMIDE; RESPONSE ASSESSMENT; TUMOR PROGRESSION; MALIGNANT GLIOMA; RADIOTHERAPY; FEATURES; CRITERIA; CONCOMITANT | Glioblastoma; Machine learning; Pseudoprogression; Radiotherapy | antineoplastic agent; gadolinium; adult; aged; analytical parameters; area under the precision recall curve; Article; calibration; cancer chemotherapy; cancer diagnosis; cancer growth; cancer patient; cancer radiotherapy; chemoradiotherapy; clinical feature; clinician; controlled study; cross validation; data base; deep learning; disease course; feasibility study; female; glioblastoma; human; human tissue; machine learning; major clinical study; male; medical decision making; nuclear magnetic resonance imaging; online system; prediction; probability; radiation oncology; university hospital | English | 2020 | 2020-09 | 10.3390/cancers12092706 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | O-GlcNAc Transferase Inhibitor Synergistically Enhances Doxorubicin-Induced Apoptosis in HepG2 Cells | Simple Summary We found that the combination treatment of doxorubicin (DOX) and O-GlcNAc transferase (OGT) inhibitor OSMI-1 has synergic therapeutic efficacy in the treatment of liver cancer. Our data show that DOX displayed cytotoxicity via the activation of p53 and the inflammatory NF-kappa B signaling pathway, while OSMI-1 evoked the ER stress response and inhibited NF-kappa B signaling. Therefore, DOX in combination with the OSMI-1 group showed a 20-fold reduction of tumor formation, whereas the DOX alone group reduced by 1.8-fold compared with control in a HepG2 cell xenograft model. The combination of chemotherapy with chemosensitizing agents is a common approach to enhance anticancer activity while reducing the dose-dependent adverse side effects of cancer treatment. Herein, we investigated doxorubicin (DOX) and O-GlcNAc transferase (OGT) inhibitor OSMI-1 combination treatment, which significantly enhanced apoptosis in hepatocellular carcinoma cells (HepG2) as a result of synergistic drug action in disparate stress signaling pathways. Treatment with a low dose of DOX or a suboptimal dose of OSMI-1 alone did not induce apoptotic cell death in HepG2 cells. However, the combination of DOX with OSMI-1 in HepG2 cells synergistically increased apoptotic cell death through the activation of both the p53 and mitochondrial Bcl2 pathways compared to DOX alone. We also demonstrated that the combination of DOX and OSMI-1 stimulated cell death, dramatically reducing cell proliferation and tumor growth in vivo using a HepG2 xenograft mouse model. These findings indicate that OSMI-1 acts as a potential chemosensitizer by enhancing DOX-induced cell death. This study provides insight into a possible mechanism of chemotherapy resistance, identifies potential novel drug targets, and suggests that OGT inhibition could be utilized in clinical applications to treat hepatocellular carcinoma as well as other cancer types. | Lee, Su Jin; Kwon, Oh-Shin | Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea | 57213176234; 7402195859 | neojove79@knu.ac.kr;oskwon@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 12 | 11 | SCIE | ONCOLOGY | 2020 | 6.639 | 20.9 | 1.35 | 2025-06-25 | 36 | 33 | O-GlcNAc transferase inhibitor; doxorubicin; apoptosis; P53; NF-κ B; ER stress | NF-KAPPA-B; STRESS; P53; MECHANISMS; PHOSPHORYLATION; GLYCOSYLATION; GLCNACYLATION; METABOLISM; TARGET; STATE | Apoptosis; Doxorubicin; ER stress; NF-κB; O-GlcNAc transferase inhibitor; P53 | doxorubicin; osmi 1; protein bcl 2; protein p53; transferase inhibitor; unclassified drug; acylation; animal cell; animal experiment; animal model; animal tissue; apoptosis; Article; cancer inhibition; cell proliferation; cellular stress signal; controlled study; drug mechanism; drug potentiation; drug resistance; drug targeting; enzyme activation; female; Hep-G2 cell line; human; human cell; in vivo study; liver cell carcinoma; monotherapy; mouse; nonhuman; tumor xenograft | English | 2020 | 2020-11 | 10.3390/cancers12113154 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The Role of Primary Tumor Resection in Colorectal Cancer Patients with Asymptomatic, Synchronous, Unresectable Metastasis: A Multicenter Randomized Controlled Trial | We aimed to assess the survival benefits of primary tumor resection (PTR) followed by chemotherapy in patients with asymptomatic stage IV colorectal cancer with asymptomatic, synchronous, unresectable metastases compared to those of upfront chemotherapy alone. This was an open-label, prospective, randomized controlled trial (ClnicalTrials.gov Identifier: NCT01978249). From May 2013 to April 2016, 48 patients (PTR,n= 26; upfront chemotherapy,n= 22) diagnosed with asymptomatic colorectal cancer with unresectable metastases in 12 tertiary hospitals were randomized (1:1). The primary endpoint was two-year overall survival. The secondary endpoints were primary tumor-related complications, PTR-related complications, and rate of conversion to resectable status. The two-year cancer-specific survival was significantly higher in the PTR group than in the upfront chemotherapy group (72.3% vs. 47.1%;p= 0.049). However, the two-year overall survival rate was not significantly different between the PTR and upfront chemotherapy groups (69.5% vs. 44.8%,p= 0.058). The primary tumor-related complication rate was 22.7%. The PTR-related complication rate was 19.2%, with a major complication rate of 3.8%. The rates of conversion to resectable status were 15.3% and 18.2% in the PTR and upfront chemotherapy groups. While PTR followed by chemotherapy resulted in better two-year cancer-specific survival than upfront chemotherapy, the improvement in the two-year overall survival was not significant. | Park, Eun Jung; Baek, Jeong-Heum; Choi, Gyu-Seog; Park, Won Cheol; Yu, Chang Sik; Kang, Sung-Bum; Min, Byung Soh; Kim, Jae Hwang; Kim, Hyeong Rok; Lee, Bong Hwa; Oh, Jae Hwan; Jeong, Seung-Yong; Jung, Minkyu; Ahn, Joong; Baik, Seung Hyuk | Yonsei Univ, Gangnam Severance Hosp, Dept Surg, Div Colon & Rectal Surg,Coll Med, Seoul 06273, South Korea; Gachon Univ, Gil Med Ctr, Dept Surg, Coll Med, Incheon 21565, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Colorectal Canc Ctr, Sch Med, Daegu 41404, South Korea; Wonkwang Univ, Dept Surg, Sch Med, Iksan 54538, South Korea; Univ Ulsan, Asan Med Ctr, Dept Colon & Rectal Surg, Coll Med, Seoul 05505, South Korea; Seoul Natl Univ, Coll Med, Dept Surg, Bundang Hosp, Seongnam 13620, South Korea; Yonsei Univ, Severance Hosp, Dept Surg, Div Colon & Rectal Surg,Coll Med, Seoul 03722, South Korea; Yeungnam Univ, Dept Surg, Coll Med, Daegu 42415, South Korea; Chonnam Natl Univ, Dept Surg, Hwasun Hosp & Med Sch, Hwasun 58128, South Korea; Hallym Univ, Dept Surg, Sacred Heart Hosp, Anyang 14068, South Korea; Natl Canc Ctr, Ctr Colorectal Canc, Res Inst & Hosp, Goyang 10408, South Korea; Seoul Natl Univ, Coll Med, Colorectal Canc Ctr, Dept Surg,Canc Hosp, Seoul 03080, South Korea; Yonsei Univ, Yonsei Canc Ctr, Dept Internal Med, Div Med Oncol,Coll Med, Seoul 03722, South Korea | ; KANG, MIN KYU/ACI-8824-2022; Jeong, Seung-Yong/J-5643-2012; Baek, Jeong-Heum/L-3867-2019; Park, Eun/W-1340-2019 | 56072952500; 34876161300; 8058759100; 57201583586; 7404977414; 8430671000; 35269560900; 7601384176; 55943824800; 25959597100; 7402155044; 7402425099; 56423037400; 7403019591; 15072885400 | parkwc@wku.ac.kr;gsbaek@gilhospital.com;kyuschoi@mail.knu.ac.kr;csyu@amc.seoul.kr;kangsb@snubh.org;BSMIN@yuhs.ac;jhkimgs@ynu.ac.kr;drkhr@jnu.ac.kr;a15211@daum.net;jayoh@ncc.re.kr;syjeong@snu.ac.kr;MINKJUNG@yuhs.ac;VVSWM513@yuhs.ac;whitenoja@yuhs.ac; | CANCERS | CANCERS | 2072-6694 | 12 | 8 | SCIE | ONCOLOGY | 2020 | 6.639 | 20.9 | 1.55 | 2025-06-25 | 48 | 27 | primary tumor resection; colorectal neoplasm; synchronous unresectable metastasis; non-curative resection; neoplasm metastasis; chemotherapy; overall survival | 1ST-LINE TREATMENT; COMBINATION CHEMOTHERAPY; PLUS BEVACIZUMAB; COLON-CANCER; FLUOROURACIL; CETUXIMAB; SURGERY; OXALIPLATIN; LEUCOVORIN; IRINOTECAN | Chemotherapy; Colorectal neoplasm; Neoplasm metastasis; Non-curative resection; Overall survival; Primary tumor resection; Synchronous unresectable metastasis | fluorouracil; folinic acid; irinotecan; oxaliplatin; adult; aged; Article; asymptomatic disease; cancer chemotherapy; cancer patient; cancer specific survival; cancer staging; cancer surgery; clinical article; clinical feature; clinical outcome; colorectal cancer; controlled study; diarrhea; female; fever; hand foot syndrome; human; human tissue; intestine obstruction; Korea; male; metastasis; multicenter study; nausea; neuropathy; open study; overall survival; pain; pneumonia; postoperative ileus; prospective study; randomized controlled trial; rash; seroma; survival rate; tertiary care center; vomiting | English | 2020 | 2020-08 | 10.3390/cancers12082306 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evolution of the Mesozoic Yuljeon Basin in South Korea and its tectonic implication | The Mesozoic Yuljeon Basin (YB) is a small scale non-marine sedimentary basin in the northeastern part of the Gyeonggi Massif in the Korean Peninsula. The YB consists of two lithostratigraphic units, the Munamdong and Yuljeon formations. Based on an integrated study of stratigraphy, structural geology, geochronology, and geochemistry, major episodes of the YB have been investigated. In the late Triassic (after 227 Ma), the YB was formed in a tectonic setting, wherein crust was extended and uplifted, which resulted in deposition of the Munamdong Formation. In the latest early Jurassic (circa 180 Ma), the Yuljeon Formation was deposited in association with volcanic activity in a continental magmatic arc setting. On entering the middle Jurassic (circa 174 Ma), extension in the YB stopped and then basin inversion occurred due to contractional deformation. The middle Jurassic thermal pulse in the area generated various scale igneous rocks and induced hydrothermal circulations, which created suitable conditions for fault activity with help of fluid pressure. This study demonstrates that the YB formed with sedimentation in a post-collisional extensional setting related to the Songrim Orogeny, and then it was enlarged with volcanic-related sedimentation in a continental arc setting related to the Daebo Orogeny, and lastly it was followed by basin inversion with arc magmatism in the same continental arc setting, reflecting the temporal and spatial changes in regional tectonics. Moreover, the general provenance characteristics for the early Mesozoic strata in the eastern North China Block, Gyeonggi Massif of South Korea, and southwest Japan, can be geochronologically correlated. The sedimentary rocks record the distinctive tectonothermal histories of East Asia such as the middle Paleoproterozoic orogens in the eastern North China Block, the Permo-Triassic continental collision between North and South China Blocks, and the subduction of Paleo-Pacific plate during the Mesozoic. (C) 2020 Elsevier B.V. All rights reserved. | Choi, Younggi; Ryu, In Chang; Seo, Jieun; Oh, Chang Whan | Kyungpook Natl Univ, Dept Geol, Daegu 41566, South Korea; Korea Resources Corp, Dept Interkorea Resource Cooperat, Wonju 26464, South Korea; Korea Univ, Dept Earth & Environm Sci, Seoul 136701, South Korea; Chonbuk Natl Univ, Dept Earth & Environm Sci, Jeonju 561756, South Korea | 57797282800; 7006705952; 15036859700; 57218942220 | inchang@knu.ac.kr; | LITHOS | LITHOS | 0024-4937 | 1872-6143 | 366 | SCIE | GEOCHEMISTRY & GEOPHYSICS;MINERALOGY | 2020 | 4.004 | 21.0 | 0.3 | 2025-06-25 | 5 | 5 | Post-collision; Subduction; Basin inversion; Yuljeon basin; Korea | ODESAN COLLISION BELT; NORTH CHINA CRATON; U-PB GEOCHRONOLOGY; DETRITAL-ZIRCON; GYEONGGI MASSIF; HONGCHEON AREA; VOLCANIC-ROCKS; CHEMICAL CLASSIFICATION; SEDIMENTARY RESPONSE; CONTINENTAL-CRUST | Basin inversion; Korea; Post-collision; Subduction; Yuljeon basin | Gyeonggi Massif; South Korea; basin analysis; geochemistry; geochronology; integrated approach; lithostratigraphy; Mesozoic; sedimentary basin; structural geology; tectonics | English | 2020 | 2020-08 | 10.1016/j.lithos.2020.105560 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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