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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Paralleled H-Bridge Multilevel Switching-Cell Current Source Inverter | The paralleled H-bridge multilevel current source inverter (PHB-MLCSI) is widely used in industry, especially for high-power and medium-voltage applications. Even so, the risk of an open-circuit fault (OCF), which is the most common and destructive failure among all conventional CSIs also jeopardizes the reliability of the standard PHB-MLCSI. To overcome this major shortcoming, a new topology called paralleled H-bridge multilevel switching-cell current source inverter is introduced in this article. Thus, OCF is no longer an issue in the proposed topology, even if it occurs frequently or is caused by switch turn on mismatch/delay among all complementary switches in every switching cycle. The phase-shifted pulsewidth modulation (PS-PWM) method is used to control the proposed topology due to the following two reasons: 1) other PWM schemes, such as level shifted and low/fundamental frequency or half-cycle PWMs cannot overcome OCF if it occurs frequently; 2) mismatches in gating signals, tolerance in parameters of the input dc smoothing inductors (chokes), and unequal input dc voltage values are other concerns in the PHB-MLCSI that may deteriorate the performance of the converter. The PS-PWM method with redundant switching states is a proper modulation technique to handle all the aforementioned mismatch issues to an acceptable level. A variety of experimental tests are conducted to validate the feasibility of the proposed solution. Finally, a comparison is drawn between the proposed circuit and three other existing MLCSIs, further highlighting its distinctive features. | Faraji, Faramarz; Cha, Honnyong | Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea | ; Faraji, Faramarz/J-4074-2019 | 57191226987; 24450248400 | faraji.u@gmail.com;chahonny@knu.ac.kr; | IEEE TRANSACTIONS ON POWER ELECTRONICS | IEEE T POWER ELECTR | 0885-8993 | 1941-0107 | 39 | 5 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 6.5 | 11.9 | 1.07 | 2025-05-07 | 3 | 5 | Current source inverter; multilevel converter; overlap-time; phase-shifted pulsewidth modulation (PS-PWM); reliability | CURRENT-SOURCE CONVERTER; VOLTAGE-SOURCE; TOPOLOGIES | Current source inverter; multilevel converter; overlap-time; phase-shifted pulsewidth modulation (PS-PWM); reliability | Bridge circuits; Electric inverters; Pulse width modulation; Reliability; Timing circuits; Circuit faults; Current source inverter; H-bridges; Inductor; Inverter; Multilevel converter; Multilevels; Overlap-time; Phase-shifted PWM; Pulsewidth modulations (PWM); Topology | English | 2024 | 2024-05 | 10.1109/tpel.2024.3367372 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Plastid phylogenomics of Robinsonia (Senecioneae; Asteraceae), endemic to the Juan Fernández Islands: insights into structural organization and molecular evolution | BackgroundThe genus Robinsonia DC. (tribe Senecioneae, Asteraceae) endemic to the Juan Fern & aacute;ndez Islands in Chile is one of the most conspicuous insular plant groups in the world. Unlike typical herbaceous Asteraceae plants, these plants demonstrate spectacular and unusual rosette tree growth forms as shown by the alpine giant senecios (genus Dendrosenecio, tribe Senecioneae) endemic to the East African mountains. However, monophyly of the genus and phylogenetic relationships among species of Robinsonia as well as their plastome evolution remain elusive. This study aims to explore their phylogeny, species diversification, and molecular evolution based on the complete plastome sequences in the context of adaptive radiation on oceanic islands.ResultsThe insular Robinsonia plastomes are highly conserved in their structures and organization of contents. Five divergence hotspots as potential chloroplast markers and five positively selected coding genes (accD, ndhF, rpoA, ycf1, and ycf2) are identified. Robinsonia plastomes has an overall nucleotide diversity higher than that of the sky island Dendrosenecio, but much lower than herbaceous Senecio. Phylogenetic analysis demonstrates the monophyly of Robinsonia and identifies two major infrageneric lineages. Both Robinsonia and Dendrosenecio are deeply nested within large genus Senecio.ConclusionsWhile plastid genomes of Robinsonia are highly conserved, their sequences strongly demonstrated the monophyly of the genus and inferred robust interspecific relationships, including herbaceous Senecio and woody Dendrosenecio. Different sets of positively selected chloroplast genes, five for Robinsonia and two for Dendrosenecio, may play an important role in the adaptation strategies of these fascinating woody species in insular and continental sky island habitats. Overall phylogenetic positions and sister lineages of Robinsonia and Dendrosenecio require additional study based on broader sampling of Senecio. | Cho, Myong-Suk; Yang, JiYoung; Kim, Seon-Hee; Crawford, Daniel J.; Stuessy, Tod F.; Lopez-Sepulveda, Patricio; Kim, Seung-Chul | Sungkyunkwan Univ, Dept Biol Sci, Suwon 16419, South Korea; Kyungpook Natl Univ, Res Inst Dok Do & Ulleung Do Isl, Daegu 41566, South Korea; Kyoto Univ, Grad Sch Sci, Dept Bot, Kyoto, Japan; Univ Kansas, Dept Ecol & Evolutionary Biol, Lawrence, KS 66045 USA; Univ Kansas, Biodivers Inst, Lawrence, KS 60045 USA; Ohio State Univ, Herbarium, Columbus, OH 43212 USA; Ohio State Univ, Dept Evolut Ecol & Organismal Biol, Columbus, OH 43212 USA; Univ Vienna, Dept Bot & Biodivers Res, A-1030 Vienna, Austria; Univ Concepcion, Dept Bot, Concepcion, Chile | Kim, Seung-Chul/AAR-6157-2020 | 56326352700; 55193226000; 57196226213; 7403085620; 7003950083; 55588365400; 57214983739 | sonchus96@skku.edu; | BMC PLANT BIOLOGY | BMC PLANT BIOL | 1471-2229 | 24 | 1 | SCIE | PLANT SCIENCES | 2024 | 4.8 | 11.9 | 0 | 2025-05-07 | 2 | 2 | Adaptive radiation; Asteraceae; Critically endangered; Insular woodiness; Juan Fern & aacute;ndez Islands; Plastome evolution | ADAPTIVE RADIATION; FERNANDEZ-ISLANDS; DENDROSERIS COMPOSITAE; FLAVONOID EVOLUTION; WOODY SONCHUS; CHLOROPLAST; LACTUCEAE; SELECTION; TOOLS; CRASSULACEAE | Adaptive radiation; Asteraceae; Critically endangered; Insular woodiness; Juan Fernández Islands; Plastome evolution | Asteraceae; Chile; Evolution, Molecular; Genome, Plastid; Islands; Phylogeny; Plastids; Asteraceae; Chile; genetics; island (geological); molecular evolution; phylogeny; plastid; plastid genome | English | 2024 | 2024-10-28 | 10.1186/s12870-024-05711-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Suppression of AC Coupling Effects on HVdc Transmission System Based on MMC | As the number of dc transmission systems increases, more dc lines are constructed in close proximity to existing ac transmission lines. This article deals with ac coupling effect on dc transmission line of modular multilevel converter (MMC) based HVdc system due to neighboring ac lines. Based on a decoupled control of MMC, the operation of MMC is investigated with analytic expression. Furthermore, a new dc bus current controller is proposed to mitigate this effect. By applying the proposed controller, the MMC-HVdc system can operate without any interference from the ac coupling effect. The effectiveness of the proposed controller is demonstrated through both full-scale simulation and scaled experimental studies. | Lee, Joon-Hee; Jung, Jae-Jung; Sul, Seung-Ki | Ulsan Natl Inst Sci & Technol UNIST, Dept Elect Engn, Ulsan 44919, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Seoul Natl Univ, Dept Elect & Comp Engn, Seoul 08826, South Korea | ; Jung, Jae-Jung/AAG-4515-2021 | 58744318000; 55368433400; 7005539275 | joonhee.lee@unist.ac.kr;jj.jung@knu.ac.kr;sulsk@snu.ac.kr; | IEEE TRANSACTIONS ON POWER ELECTRONICS | IEEE T POWER ELECTR | 0885-8993 | 1941-0107 | 39 | 9 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 6.5 | 11.9 | 1.19 | 2025-04-16 | 1 | 3 | Coupling suppression; electromagnetic coupling; harmonic suppression; high voltage DC transmission; modular multilevel converter; Coupling suppression; electromagnetic coupling; harmonic suppression; high voltage DC transmission; modular multilevel converter | Coupling suppression; electromagnetic coupling; harmonic suppression; high voltage DC transmission; modular multilevel converter | Bandpass filters; Electric lines; HVDC power transmission; Coupling effect; HVDC systems; HVDC transmission; HVDC transmission system; Legged locomotion; Modulars; Multilevel converter; Power harmonic filters; Power transmission lines; Regulator; Controllers | English | 2024 | 2024-09 | 10.1109/tpel.2024.3405204 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Taxonomic reinvestigation of the genus Tetradesmus (Scenedesmaceae; Sphaeropleales) based on morphological characteristics and chloroplast genomes | The genus Tetradesmus (Scenedesmaceae; Sphaeropleales) comprises one of the most abundant green algae in freshwater environments. It includes morphologically diverse species that exhibit bundle-like, plane-arranged coenobia, and unicells, because several different Scenedesmus-like groups were integrated into this genus based on phylogenetic analysis. Nevertheless, there is no clear information regarding the phylogenetic relationship of Tetradesmus species, determined using several marker genes, because of low phylogenetic support and insufficient molecular data. Currently, genome information is available from diverse taxa, which could provide high-resolution evolutionary relationships. In particular, phylogenetic studies using chloroplast genomes demonstrated the potential to establish high-resolution phylogenetic relationships. However, only three chloroplast genomes are available from the genus Tetradesmus. In this study, we newly generated 9 chloroplast genomes from Tetradesmus and constructed a high-resolution phylogeny using a concatenated alignment of 69 chloroplast protein sequences. We also report one novel species (T. lancea), one novel variety (T. obliquus var. spiraformis), and two novel formae (T. dissociatus f. oviformis, T. obliquus f. rectilineare) within the genus Tetradesmus based on morphological characteristics (e.g., cellular arrangements and coenobial types) and genomic features (e.g., different exon-intron structures in chloroplast genomes). Moreover, we taxonomically reinvestigated the genus Tetradesmus based on these results. Altogether, our study can provide a comprehensive understanding of the taxonomic approaches for investigating this genus. | Cho, Hyeon Shik; Lee, JunMo | Kyungpook Natl Univ, Dept Oceanog, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Inst Oceanog, Daegu, South Korea | 58910576800; 57217851052 | junmolee@knu.ac.kr; | FRONTIERS IN PLANT SCIENCE | FRONT PLANT SCI | 1664-462X | 15 | SCIE | PLANT SCIENCES | 2024 | 4.8 | 11.9 | 2.02 | 2025-04-16 | 4 | 5 | Tetradesmus; cellular arrangement; coenobial type; chloroplast genome; phylogeny | GREEN-ALGAE; CHLOROPHYTA; CHODATODESMUS; ALGORITHM; GENES; NOV. | cellular arrangement; chloroplast genome; coenobial type; phylogeny; Tetradesmus | English | 2024 | 2024-02-14 | 10.3389/fpls.2024.1303175 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Technique for Mitigating Voltage Ripple of DC-Link Capacitors in a Three-Level NPC Utilizing a Zigzag Transformer | In neutral point clamped (NPC) converters, the voltage ripples in each dc-link capacitor are mainly influenced by the third harmonic component in the neutral point of the three-level NPC converter. These low-order harmonic voltage ripples distort the output of the converter and compromise system stability. Moreover, as the converter's output increases, the capacitor's ripple component escalates correspondingly, necessitating capacitors with a higher capacitance to maintain the reliability of the NPC converter. In this article, a novel technique is introduced that is designed to mitigate voltage ripples in the dc-link capacitor of three-level NPC converters. By employing a zigzag transformer, the method effectively compensates for the third harmonic component of the voltage in the dc link, resulting in a significant reduction of ripple. The validity and effectiveness of the proposed method are corroborated through comprehensive simulations and experiments. | Song, Geum Seop; Cui, Shenghui; Jung, Jae-Jung | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Seoul Natl Univ, Dept Elect & Comp Engn, Seoul 08826, South Korea; Seoul Natl Univ, SNU Elect Power Res Inst, Seoul 08826, South Korea | 57223916437; 56157479900; 55368433400 | kmkwoo@knu.ac.kr;cuish@snu.ac.kr;jj.jung@knu.ac.kr; | IEEE TRANSACTIONS ON POWER ELECTRONICS | IEEE T POWER ELECTR | 0885-8993 | 1941-0107 | 39 | 9 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 6.5 | 11.9 | 0 | 2025-04-16 | 0 | 0 | Capacitors; Harmonic analysis; Switches; Voltage; Transformers; Topology; Voltage control; Capacitor voltage ripple; dc distribution; neutral point current; three-level neutral point clamped (NPC) converter; zigzag transformer | AC; CONVERTER; QUALITY | Capacitor voltage ripple; dc distribution; neutral point current; three-level neutral point clamped (NPC) converter; zigzag transformer | Capacitance; DC transformers; Electric power distribution; Power converters; System stability; Voltage control; 3 levels; 3-level neutral point clamped converter; Capacitor voltage ripple; DC distribution; Neutral point current; Neutral points; Neutral-point clamped converters; Point currents; Transformer; Zigzag transformer; Harmonic analysis | English | 2024 | 2024-09 | 10.1109/tpel.2024.3407954 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The PGPR Bacillus aryabhattai promotes soybean growth via nutrient and chlorophyll maintenance and the production of butanoic acid | Plant growth-promoting rhizobacteria (PGPR) colonize plant roots, establish a mutualistic relationship with the plants and help them grow better. This study reports novel findings on the plant growth-promoting effects of the PGPR Bacillus aryabhattai. Soil was collected from a soybean field, PGPR were isolated, identified, and characterized for their ability to promote plant growth and development. The bacterium was isolated from the soybean rhizosphere and identified as B. aryabhattai strain SRB02 via 16s rRNA sequencing. As shown by SEM, the bacterium successfully colonized rice and soybean roots within 2 days and significantly promoted the growth of the GA-deficient rice cultivar Waito-C within 10 days, as well as the growth of soybean plants with at least six times longer shoots, roots, higher chlorophyll content, fresh, and dry weight after 10 days of inoculation. ICP analysis showed up to a 100% increase in the quantity of 18 different amino acids in the SRB02-treated soybean plants. Furthermore, the 2-DE gel assay indicated the presence of several differentially expressed proteins in soybean leaves after 24 hrs of SRB02 application. MALDI-TOF-MS identified beta-conglycinin and glycinin along with several other proteins that were traced back to their respective genes. Analysis of bacterial culture filtrates via GCMS recorded significantly higher quantities of butanoic acid which was approximately 42% of all the metabolites found in the filtrates. The application of 100 ppm butanoic acid had significantly positive effects on plant growth via chlorophyll maintenance. These results establish the suitability of B. aryabhattai as a promising PGPR for field application in various crops. | Mun, Bong-Gyu; Hussain, Adil; Park, Yeon-Gyeong; Kang, Sang-Mo; Lee, In-Jung; Yun, Byung-Wook | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Appl Biosci, Daegu, South Korea; Chungbuk Natl Univ, Dept Environm & Biol Chem, Cheongju, South Korea; Abdul Wali Khan Univ, Dept Agr, Mardan, Khyber Pakhtunk, Pakistan | Hussain, Dr. Adil/K-6016-2018; Lee, In-Jung/GLS-0432-2022; Kang, Sang-Mo/MBG-7823-2025; Mun, BongGyu/GYD-6010-2022 | 57147241300; 41961162600; 57208600369; 56189696900; 16425830900; 8245123600 | adilhussain@awkum.edu.pk;bwyun@knu.ac.kr; | FRONTIERS IN PLANT SCIENCE | FRONT PLANT SCI | 1664-462X | 15 | SCIE | PLANT SCIENCES | 2024 | 4.8 | 11.9 | 6.05 | 2025-04-16 | 11 | 12 | plant growth promoting rhizobacteria; Bacillus aryabhattai; chlorophyll; butanoic acid; SRB02 | PLANT-GROWTH; PSEUDOMONAS-AERUGINOSA; SALT STRESS; RHIZOBACTERIA; RICE; GIBBERELLIN; WHEAT; IDENTIFICATION; ENHANCEMENT; QUANTITIES | Bacillus aryabhattai; butanoic acid; chlorophyll; plant growth promoting rhizobacteria; SRB02 | English | 2024 | 2024-02-19 | 10.3389/fpls.2024.1341993 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The proximate composition of vegetables enriched by incorporation of municipal solid waste into fertilizers and its impacts on environment and human health | The recent over production of municipal solid waste (MSW) poses a significant threat to both the ecosystem and human health. Utilizing MSW for agricultural purposes has emerged as a promising strategy to reduce solid waste disposal while simultaneously increasing soil fertility. To explore this potential solution further, an experiment was designed to assess the impact of varying concentrations of MSW (25%, 50%, and 75%) on the proximate composition of 15 different vegetable species. The experiment, conducted between 2018 and 2019, involved treating soil with different levels of solid waste and analyzing the proximate components, such as crude protein, dry matter, crude fiber, crude fat, and moisture content, in the 15 selected crops. The results indicate that the application of 25% MSW significantly increased the levels of crude protein, crude fiber, dry matter, and fat in Spinacia oleracea, Solanum tuberosum, Solanum melongena, and Abelmoschus esculentus. Conversely, the addition of 75% MSW notably elevated the moisture and ash content in Cucumis sativus. Correlation and scatter matrix analyses were conducted to elucidate the relationships between the protein, fiber, dry matter, ash, and fat contents. Principal component analysis and clustering confirmed the substantial impact of Treatment₁ (25% MSW) and Treatment₃ (75% MSW) on the proximate composition of the aforementioned vegetables, leading to their categorization into distinct groups. Our study highlights the efficacy of using 25% MSW to enhance the proximate composition and nutritional value of vegetables. Nonetheless, further research is warranted to investigate the mineral, antioxidant, vitamin, and heavy metal contents in the soil over an extended period of MSW application. | Ashfaq, Asma; Khan, Zafar Iqbal; Arif, Muhammad; Abbas, Ghulam; Abbas, Toqeer; Gatasheh, Mansour K.; Shaffique, Shifa; Shah, Anis Ali | Univ Sargodha, Dept Bot, Sargodha, Punjab, Pakistan; Univ Sargodha, Coll Agr, Dept Anim Sci, Sargodha, Pakistan; Univ Agr Dera Ismail Khan KP, Dept Biotechnol, Dera Ismail Khan, Pakistan; King Saud Univ, Coll Sci, Dept Biochem, POB 2455, Riyadh 11451, Saudi Arabia; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, 80 Daehak Ro, Daegu 41566, South Korea; Univ Educ, Dept Bot, Div Sci & Technol, Lahore, Punjab, Pakistan | ; Arif, Muhammad/P-2958-2019; Abbas, Ghulam/GVT-8242-2022; Gatasheh, Mansour/AAP-9414-2021; Khan, Zafar/J-7029-2015; Abbas, Toqeer/KHY-4557-2024; shaffique, shifa/KUC-7102-2024; Ashfaq, Asma/LSL-6406-2024; Shah, Dr. Anis/AAV-2232-2020 | 56397895300; 10938887000; 58822065200; 57211681307; 57202833813; 15742571400; 57203898867; 57211606140 | asma.ashfaq@uos.edu.pk; | BMC PLANT BIOLOGY | BMC PLANT BIOL | 1471-2229 | 24 | 1 | SCIE | PLANT SCIENCES | 2024 | 4.8 | 11.9 | 0.6 | 2025-05-07 | 1 | 1 | Biowaste; Contents of proximate; Soil fertility; Environment; Toxicity | SOIL AMENDMENT; SANDY SOIL; MANAGEMENT; FRUITS | Biowaste; Contents of proximate; Environment; Soil fertility; Toxicity | Environment; Fertilizers; Humans; Refuse Disposal; Soil; Solid Waste; Vegetables; fertilizer; chemistry; environment; human; procedures; soil; solid waste; vegetable; waste disposal | English | 2024 | 2024-09-30 | 10.1186/s12870-024-05581-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The rhizobacterial Priestia megaterium strain SH-19 mitigates the hazardous effects of heat stress via an endogenous secondary metabolite elucidation network and molecular regulation signalling | Global warming is a leading environmental stress that reduces plant productivity worldwide. Several beneficial microorganisms reduce stress; however, the mechanism by which plant-microbe interactions occur and reduce stress remains to be fully elucidated. The aim of the present study was to elucidate the mutualistic interaction between the plant growth-promoting rhizobacterial strain SH-19 and soybeans of the Pungsannamul variety. The results showed that SH-19 possessed several plant growth-promoting traits, such as the production of indole-3-acetic acid, siderophore, and exopolysaccharide, and had the capacity for phosphate solubilisation. The heat tolerance assay showed that SH-19 could withstand temperatures up to 45 degrees C. The strain SH-19 was identified as P. megaterium using the 16S ribosomal DNA gene sequence technique. Inoculation of soybeans with SH-19 improved seedling characteristics under high-temperature stress. This may be due to an increase in the endogenous salicylic acid level and a decrease in the abscisic acid level compared with the negative control group. The strain of SH-19 increased the activity of the endogenous antioxidant defense system, resulting in the upregulation of GSH (44.8%), SOD (23.1%), APX (11%), and CAT (52.6%). Furthermore, this study involved the transcription factors GmHSP, GmbZIP1, and GmNCED3. The findings showed upregulation of the two transcription factors GmbZIP1 (17%), GmNCED3 (15%) involved in ABA biosynthesis and induced stomatal regulation, similarly, a downregulation of the expression pattern of GmHSP by 25% was observed. Overall, the results of this study indicate that the strain SH-19 promotes plant growth, reduces high-temperature stress, and improves physiological parameters by regulating endogenous phytohormones, the antioxidant defense system, and genetic expression. The isolated strain (SH-19) could be commercialized as a biofertilizer. | Shaffique, Shifa; Shah, Anis Ali; Peter, Odongkara; Injamum-Ul-Hoque, Md.; Elansary, Hosam O.; Kang, Sang-Mo; Al Azzawi, Tiba Nazar Ibrahim; Yun, Byung-Wook; Lee, In-Jung | Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, 80 Daehak Ro, Daegu 41566, South Korea; Univ Educ, Dept Bot, Div Sci & Technol, Lahore, Punjab, Pakistan; King Saud Univ, Coll Food & Agr Sci, Plant Prod Dept, Riyadh 11451, Saudi Arabia | ; shaffique, shifa/KUC-7102-2024; Shah, Dr. Anis/AAV-2232-2020; Lee, In-Jung/GLS-0432-2022; Kang, Sang-Mo/MBG-7823-2025; Injamum-Ul-Hoque/ADJ-9141-2022 | 57203898867; 57211606140; 58663785500; 58663974700; 35388049900; 56189696900; 57224980187; 8245123600; 16425830900 | anisalibot@gmail.com;ijlee@knu.ac.kr; | BMC PLANT BIOLOGY | BMC PLANT BIOL | 1471-2229 | 24 | 1 | SCIE | PLANT SCIENCES | 2024 | 4.8 | 11.9 | 1.21 | 2025-05-07 | 3 | 4 | SH-19; Temperature stress; Phytohormones; ROS | Phytohormones; ROS; SH-19; Temperature stress | Burkholderiales; Glycine max; Heat-Shock Response; Plant Growth Regulators; Salicylic Acid; Secondary Metabolism; Signal Transduction; Symbiosis; phytohormone; salicylic acid; Burkholderiales; genetics; heat shock response; metabolism; microbiology; physiology; secondary metabolism; signal transduction; soybean; symbiosis | English | 2024 | 2024-09-04 | 10.1186/s12870-024-05534-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Unveiling the protective role of anthocyanin in rice: insights into drought-induced oxidative stress and metabolic regulation | This study investigates the impact of anthocyanin treatment on rice plants under drought stress, focusing on phenotypic, molecular, and biochemical responses. Anthocyanin were treated to one month old plants one week before the droughtexposure. Drought stress was imposed by using 10% polyethylene glycol (PEG 6000). Anthocyanin-treated plants exhibited significant enhancements in various traits, including growth parameters and reproductive characteristics, under normal conditions. When subjected to drought stress, these plants displayed resilience, maintaining or improving essential morphological and physiological features compared to non-treated counterparts. Notably, anthocyanin application mitigated drought-induced oxidative stress, as evidenced by reduced levels of reactive oxygen species (ROS) and lipid membrane peroxidation. The study also elucidates the regulatory role of anthocyanins in the expression of flavonoid biosynthetic genes, leading to increased levels of key secondary metabolites. Furthermore, anthocyanin treatment influenced the levels of stress-related signaling molecules, including melatonin, proline, abscisic acid (ABA), and salicylic acid (SA), contributing to enhanced stress tolerance. The enzymatic activity of antioxidants and the expression of drought-responsive genes were modulated by anthocyanins, emphasizing their role in antioxidant defense and stress response. Additionally, anthocyanin treatment positively influenced macronutrient concentrations, particularly calcium ion (Ca+), potassium ion (K+), and sodium ion (Na+), essential for cell wall and membrane stability. The findings collectively highlight the multifaceted protective effects of anthocyanins, positioning them as potential key players in conferring resilience to drought stress in rice plants. The study provides valuable insights into the molecular and physiological mechanisms underlying anthocyanin-mediated enhancement of drought stress tolerance, suggesting promising applications in agricultural practices for sustainable crop production. | Jan, Rahmatullah; Asif, Saleem; Asaf, Sajjad; Khan, Zakirullah; Kim, Kyung-Min | Kyungpook Natl Univ, Grad Sch, Dept Appl Biosci, Daegu, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu, South Korea; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa, Oman | Asaf, Sajjad/ABA-3647-2021; Jan, Rahmatullah/AIC-3439-2022; Kim, Kyung-Min Kim/C-7007-2014 | 57201981969; 57396413700; 56595059900; 57200621537; 58810294300; 34868260300 | rehmatbot@yahoo.com;kkm@knu.ac.kr; | FRONTIERS IN PLANT SCIENCE | FRONT PLANT SCI | 1664-462X | 15 | SCIE | PLANT SCIENCES | 2024 | 4.8 | 11.9 | 3.36 | 2025-04-16 | 5 | 6 | anthocyanin; drought stress; melatonin; abscisic acid; antioxidants | FLAVONOID BIOSYNTHESIS; WHEAT LEAVES; EXPRESSION; ACID; ACCUMULATION; ARABIDOPSIS; PROLINE; PLANTS; GENES; TOLERANCE | abscisic acid; anthocyanin; antioxidants; drought stress; melatonin | English | 2024 | 2024-05-28 | 10.3389/fpls.2024.1397817 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Utilization of the Winkler scale of plants using big data temperature presented by the Korea Meteorological Administration | IntroductionRice is an important food source that can provide a stable supply of calories for most people around the world. However, owing to the recent rapid temperature rise, we are facing social issues related to the increase in the Winkler scale. In this study, a strategy for screening potential candidate genes related to the yield according to the Winkler scale is presented, and the possibility of using a candidate gene identified through sequence haplotype and homology analysis as a breeding source is suggested.MethodsQTL for the Winkler scale was identified using a population of 120 double haploids derived from a cross between Cheongchoneg, Indica, and Nagdong, Japonica.Results and discussionA total of 79 candidate genes were detected in the identified QTL region, and OsHAq8 was finally screened. Through haplotype analysis, OsHAq8 was derived from the Indica group and orthologous to Graminae's activator of Hsp90 ATPase, suggesting that it is a candidate gene involved in yield according to temperature during the growing period. The expression level of OsHAq8 increased as the Winkler scale increased. The findings of this study can serve as a crucial indicator for predicting harvest time and grain quality while achieving a stable yield through marker selection and adaptation to climate change. Climate change occurs more frequently. In these situations, it is very important to predict harvest time and apply relevant candidate genes to breeding. The candidate genes presented in this study can be effectively applied to rice breeding in preparation for climate change. | Park, Jae-Ryoung; Kim, Eun-Gyeong; Jang, Yoon-Hee; Kim, Kyung-Min | Rural Dev Adm, Natl Inst Crop Sci, Crop Breeding Div, Wonju, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea | ; Kim, Kyung-Min Kim/C-7007-2014 | kkm@knu.ac.kr; | FRONTIERS IN PLANT SCIENCE | FRONT PLANT SCI | 1664-462X | 14 | SCIE | PLANT SCIENCES | 2024 | 4.8 | 11.9 | 0 | Winkler scale; harvest time; grain quality; QTL; breeding | QUANTITATIVE TRAIT LOCI; NEAR-ISOGENIC LINES; GRAIN QUALITY; ORYZA-SATIVA; AMYLOSE CONTENT; RICE; CLIMATE; IDENTIFICATION; PROTEINS; IMPACTS | English | 2024 | 2024-01-12 | 10.3389/fpls.2023.1349606 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Comparative Pharmacokinetics and Bioequivalence of Pour-On Ivermectin Formulations in Korean Hanwoo Cattle | This study aimed to conduct a bioequivalence study of applying three pour-on ivermectin formulations at a dose of 1 mg/kg on the back of Korean native beef cattle (Hanwoo). To conduct bioequivalence testing, the pharmacokinetics of three groups (control Innovator, test Generic A, and test Generic B) of five clinically healthy Korean Hanwoo cattle (average weight 500 kg) were studied. After topical application to the skin, blood samples were drawn at the indicated times. These blood samples were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The time required to reach the maximum concentration (Tmax), the maximum concentration (Cmax), and the area under the curve (AUClast) of each pharmacokinetic parameter were compared for bioequivalence. The results showed that the control had a Tmax of 41 +/- 1.24 h, a Cmax of 0.11 +/- 0.01 mu g/mL, and an AUClast of 9.33 +/- 0 h*mu g/mL). The comparator Generic A had a Tmax of 40 +/- 1.14 h, a Cmax of 0.10 +/- 0.01 (mu g/mL, and an AUClast of 9.41 +/- 0.57 h*mu g/mL, while Generic B had a Tmax of 40 +/- 2.21 h, a Cmax of 0.10 +/- 0.01 mu g/mL, and an AUClast of 9 h*mu g/mL. The values of the bioequivalence indicators Cmax, Tmax, and AUC were all within the range of 80% to 120%, confirming that all three tested formulations were bioequivalent. In conclusion, the study showed that the two generic products were bioequivalent to the original product in Hanwoo cattle. | Kim, Suyoung; Chae, Hyunyoung; Lee, Eon-Bee; Lee, Gayeong; Park, Seung-Chun; Kang, Jeongwoo | Kyungpook Natl Univ, Inst Vet Biomed Sci, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Minist Agr Food & Rural Affairs, Anim & Plant Quarantine Agcy APQA, Anim Dis Diag Div, 177 Hyeoksin 8 ro, Gimcheon Si 39660, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Physiol, Daegu 41566, South Korea | ; Park, Seung-Chun/AAV-3388-2021; Lee, Jung Bok/HHZ-3200-2022 | 58845272600; 58175968000; 57216526135; 58413330500; 7501832396; 57212201397 | yan111@knu.ac.kr;iichy33ii@korea.kr;eonbee@knu.ac.kr;yeong1129@knu.ac.kr;parksch@knu.ac.kr;hijach@korea.kr; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 13 | 1 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2024 | 4.6 | 12.0 | 0 | 2025-04-16 | 0 | 0 | ivermectin; bioequivalence; pharmacokinetics; Korean native cattle (Hanwoo) | DISPOSITION KINETICS; DORAMECTIN; MOXIDECTIN; PLASMA; PIGS | bioequivalence; ivermectin; Korean native cattle (Hanwoo); pharmacokinetics | ivermectin; accuracy; analytic method; animal experiment; area under the curve; Article; beef cattle; bioequivalence; blood sampling; calibration; controlled study; drug formulation; electrospray mass spectrometry; limit of detection; limit of quantitation; linear regression analysis; liquid chromatography-mass spectrometry; male; maximum concentration; nonhuman; pharmacokinetic parameters; pharmacokinetics; validation process | English | 2024 | 2024-01 | 10.3390/antibiotics13010003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparative Pharmacokinetics of Gentamicin C1, C1a and C2 in Healthy and Infected Piglets | Gentamicin, an aminoglycoside antibiotic, is a mixture of therapeutically active C-1, C-1a, C-2 and other minor components. Despite its decades-long use in pigs and other species, its intramuscular (IM) pharmacokinetics/pharmacodynamics (PKs/PDs) are unknown in piglets. Furthermore, the PKs of many drugs differ between healthy and sick animals. Therefore, we investigated the PKs of gentamicin after a single IM dose (10 mg/kg) in healthy piglets and piglets that were intranasally co-infected with Actinobacillus pleuropneumoniae and Pasteurella multocida (PM). The plasma concentrations were measured using validated liquid chromatography/mass spectrometry. The gentamicin exposure was 36% lower based on the area under the plasma concentration-time curve and 16% lower based on the maximum plasma concentration (C-max) in the infected piglets compared to the healthy piglets, while it was eliminated faster (shorter half-life and larger clearance) in the infected piglets compared to the healthy piglets. The clearance and volume of distribution were the highest for the C-1 component. C-1, C-1a and C-2 accounted for 22-25%, 33-37% and 40-42% of the total gentamicin exposure, respectively. The PK/PD target for the efficacy of aminoglycosides (C-max/minimum inhibitory concentration (MIC) > 10) could be exceeded for PM, with a greater magnitude in the healthy piglets. We suggest integrating this PK information with antibiotic susceptibility data for other bacteria to make informed antibiotic and dosage regimen selections against piglet infections. | Kim, Eun-Young; Kim, Tae-Won; Awji, Elias Gebru; Lee, Eon-Bee; Park, Seung-Chun | Kyungpook Natl Univ, Inst Vet Biomed Sci, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Chungnam Natl Univ, Coll Vet Med, 99 Daehak ro, Daejeon 34134, South Korea; Chungnam Natl Univ, Inst Vet Sci, 99 Daehak ro, Daejeon 34134, South Korea; Minist Agr Food & Rural Affairs, Vet Drugs & Biol Div, Anim & Plant Quarantine Agcy, Gimcheon 39660, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41566, South Korea | Kim, Tae Won/GRX-7323-2022; Park, Seung-Chun/AAV-3388-2021; Lee, Jung Bok/HHZ-3200-2022 | 55705524100; 57208587045; 55429715100; 57216526135; 7501832396 | key0@korea.kr;taewonkim@cnu.ac.kr;eliawji1@gmail.com;eonbee@gmail.com;parksch@knu.ac.kr; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 13 | 4 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2024 | 4.6 | 12.0 | 0 | 2025-05-07 | 0 | 0 | gentamicin; pharmacokinetics; pharmacodynamics; piglets; Actinobacillus pleuropneumoniae; Pasteurella multocida | NEWBORN; HORSES; CATS | Actinobacillus pleuropneumoniae; gentamicin; Pasteurella multocida; pharmacodynamics; pharmacokinetics; piglets | acetonitrile; aminoglycoside; aminoglycoside antibiotic agent; antibiotic agent; benzyl alcohol; formic acid; gentamicin; gentamicin C; nicotinamide adenine dinucleotide; propylene glycol; sodium chloride; Actinobacillus pleuropneumoniae; animal cell; animal experiment; animal model; animal tissue; antibiotic resistance; antibiotic sensitivity; area under the curve; article; Article; bacterial growth; bacterial strain; broth dilution; drug clearance; drug concentration; drug dose regimen; fungus isolation; half life time; high performance liquid chromatography; intramuscular drug administration; limit of detection; limit of quantitation; liquid chromatography; liquid chromatography-mass spectrometry; male; mass spectrometry; maximum concentration; maximum plasma concentration; measurement precision; measurement repeatability; MIC50; MIC90; minimum inhibitory concentration; multiple reaction monitoring; nonhuman; nose cartilage; particle size; Pasteurella; Pasteurella multocida; pharmacodynamics; pharmacokinetic parameters; pharmacokinetics; pig; piglet; plasma concentration-time curve; porcine pleuropneumonia; sepsis; signal noise ratio; single drug dose; statistical analysis; Student t test; time to maximum plasma concentration; volume of distribution | English | 2024 | 2024-04 | 10.3390/antibiotics13040372 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Conversion to colistin susceptibility by tigecycline exposure in colistin-resistant Klebsiella pneumoniae and its implications to combination therapy | Objectives: This study investigated the effect of tigecycline exposure on susceptibility of colistin-resistant Klebsiella pneumoniae isolates to colistin and explored the possibility of antibiotic combination at low concentrations to treat colistinresistant K. pneumoniae isolates. Methods: Twelve tigecycline-resistant (TIR) mutants were induced in vitro from wild-type, colistinresistant, and tigecycline-susceptible K. pneumoniae isolates. Antibiotic susceptibility was determined us-ing the broth microdilution method. The deduced amino acid alterations were identified for genes asso-ciated with colistin resistance, lipid A biosynthesis, and tigecycline resistance. Expression levels of genes were compared between wild-type stains and TIR mutants using quantitative real-time polymerase chain reaction (PCR). Lipid A modification was explored using MALDI-TOF mass spectrometry. Time-killing as-say was performed to assess the efficiency of combination therapy using low concentrations of colistin and tigecycline.Results: All TIR mutants except one were converted to be susceptible to colistin. These TIR mutants had mutations in the ramR gene and increased expression levels of ramA. Three genes associated with lipid A biosynthesis, lpxC, lpxL, and lpxO, were also overexpressed in TIR mutants, although no mutation was observed. Additional polysaccharides found in colistin-resistant, wild-type strains were modified in TIR mutants. Colistin-resistant K. pneumoniae strains were eliminated in vitro by combining tigecycline and colistin at 2 mg/L. In this study, we found that tigecycline exposure resulted in reduced resistance of colistin-resistant K. pneumoniae to colistin. Such an effect was mediated by regulation of lipid A modification involving ramA and lpx genes. Conclusion: Because of such reduced resistance, a combination of colistin and tigecycline in low concentrations could effectively eradicate colistinresistant K. pneumoniae strains.(c) 2023 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved. | Park, Suyeon; Choi, Jihyun; Shin, Dongwoo; Kwon, Ki Tae; Kim, Si -Ho; Wi, Yu Mi; Ko, Kwan Soo | Sungkyunkwan Univ, Sch Med, Dept Microbiol, Suwon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Sungkyunkwan Univ, Samsung Changwon Hosp, Div Infect Dis, Sch Med, Changwon Si, South Korea | ; Kim, Heui-Soo/ABF-3773-2021; Hwang, Soyoon/HHM-5762-2022 | 57219359798; 58751763600; 55709729800; 9733850500; 57194288787; 23013143100; 7202689224 | ksko@skku.edu; | INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | INT J ANTIMICROB AG | 0924-8579 | 1872-7913 | 63 | 1 | SCIE | INFECTIOUS DISEASES;MICROBIOLOGY;PHARMACOLOGY & PHARMACY | 2024 | 4.6 | 12.0 | 1.59 | 2025-04-16 | 4 | 2 | Colistin; Tigecycline; Resistance; Klebsiella pneumoniae | Colistin; Klebsiella pneumoniae; Resistance; Tigecycline | Anti-Bacterial Agents; Bacterial Proteins; Colistin; Drug Resistance, Bacterial; Humans; Klebsiella Infections; Klebsiella pneumoniae; Lipid A; Microbial Sensitivity Tests; Minocycline; Tigecycline; colistin; lipid A; messenger RNA; polysaccharide; RNA; tigecycline; antiinfective agent; bacterial protein; colistin; lipid A; minocycline; tigecycline; antibiotic sensitivity; Article; bacterial gene; bacterial strain; bacterium isolate; bacterium mutant; broth dilution; controlled study; drug exposure; gene expression level; gene mutation; in vitro study; Klebsiella pneumoniae; lipogenesis; lpxC gene; lpxL gene; lpxO gene; matrix assisted laser desorption ionization time of flight mass spectrometry; minimum inhibitory concentration; nonhuman; ramA gene; ramR gene; real time polymerase chain reaction; RNA extraction; wild type; antibiotic resistance; genetics; human; Klebsiella infection; Klebsiella pneumoniae; microbial sensitivity test | English | 2024 | 2024-01 | 10.1016/j.ijantimicag.2023.107017 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Facile Fabrication of Multifunctional Hydrogel Nanoweb Coating Using Carboxymethyl Chitosan-Based Short Nanofibers for Blood-Contacting Medical Devices | Blood-contacting medical devices (BCDs) require antithrombotic, antibacterial, and low-friction surfaces. Incorporating a nanostructured surface with the functional hydrogel onto BCD surfaces can enhance the performances; however, their fabrication remains challenging. Here, we introduce a straightforward method to fabricate a multifunctional hydrogel-based nanostructure on BCD surfaces using O-carboxymethyl chitosan-based short nanofibers (CMC-SNFs). CMC-SNFs, fabricated via electrospinning and cutting processes, are easily sprayed and entangled onto the BCD surface. The deposited CMC-SNFs form a robust nanoweb layer via fusion at the contact area of the nanofiber interfaces. The superhydrophilic CMS-SNF nanoweb surface creates a water-bound layer that effectively prevents the nonspecific adhesion of bacteria and blood cells, thereby enhancing both antimicrobial and antithrombotic performances. Furthermore, the CMC-SNF nanoweb exhibits excellent lubricity and durability on the bovine aorta. The demonstration results of the CMC-SNF coating on catheters and sheaths provide evidence of its capability to apply multifunctional surfaces simply for diverse BCDs. | Park, Se Kye; Shin, Jae Hak; Lee, Dong Uk; Jung, Jae Hee; Hwang, Injoo; Yoo, Seung Hwa; Lee, Han Chang; Park, Inyong; Kim, Woojin; Lee, Dong Yun; Choi, Dong Yun | Korea Inst Ind Technol, Biomed Mfg Technol Ctr, Yeongcheon 38822, South Korea; Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu 41566, South Korea; Sejong Univ, Dept Mech Engn, Seoul 05006, South Korea; Silla Univ, Dept Mech Engn, Busan 46958, South Korea; Jeonbuk Natl Univ, Dept Quantum Syst Engn, Jeonju 54896, South Korea; Korea Inst Machinery & Mat, Dept Sustainable Environm Res, Daejeon 34103, South Korea | ; Lee, Dong/E-7291-2013; Choi, Dong Yun/JXO-0495-2024 | 57210575824; 57355464800; 57218710149; 14919395900; 57191596696; 57190001859; 57223207961; 55456477100; 57210398468; 57211001605; 55566743200 | dongyunlee@knu.ac.kr;dychoi311@kitech.re.kr; | NANO LETTERS | NANO LETT | 1530-6984 | 1530-6992 | 24 | 29 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 9.1 | 12.0 | 0.67 | 2025-05-07 | 4 | 4 | Hydrogel-based nanostructured surface; Shortelectrospunnanofiber; Blood-contacting medical devices; Antimicrobialactivity; Antithrombotic activity; Low friction | SUPERHYDROPHILIC SURFACES; MECHANISMS; STRATEGIES; HEMOCOMPATIBILITY; THROMBOSIS; PLASMA | Antimicrobial activity; Antithrombotic activity; Blood-contacting medical devices; Hydrogel-based nanostructured surface; Low friction; Short electrospun nanofiber | Animals; Anti-Bacterial Agents; Cattle; Chitosan; Coated Materials, Biocompatible; Humans; Hydrogels; Nanofibers; Surface Properties; Blood; Chitosan; Coatings; Fabrication; Friction; Hydrogels; Mammals; Microorganisms; Nanostructures; antiinfective agent; biocompatible coated material; carboxymethyl-chitosan; chitosan; hydrogel; nanofiber; Anti-microbial activity; Anti-thrombotic activities; Blood-contacting medical device; Electrospun nanofibers; Hydrogel-based nanostructured surface; Low friction; Medical Devices; Nanostructured surface; O-carboxymethyl chitosans; Short electrospun nanofiber; animal; bovine; chemistry; human; surface property; Nanofibers | English | 2024 | 2024-06-14 | 10.1021/acs.nanolett.4c01659 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Isolation and Characterization of Novel Bacteriophages to Target Carbapenem-Resistant Acinetobacter baumannii | The spread of multidrug-resistant Acinetobacter baumannii in hospitals and nursing homes poses serious healthcare challenges. Therefore, we aimed to isolate and characterize lytic bacteriophages targeting carbapenem-resistant Acinetobacter baumannii (CRAB). Of the 21 isolated A. baumannii phages, 11 exhibited potent lytic activities against clinical isolates of CRAB. Based on host spectrum and RAPD-PCR results, 11 phages were categorized into four groups. Three phages (vBAbₐPW₈, vBAbₐSᵢW₉, and vBAbₐSₜW₁₆) were further characterized owing to their antibacterial efficacy, morphology, and whole-genome sequence and were found to lyse 37.93%, 89.66%, and 37.93%, respectively, of the 29 tested CRAB isolates. The lytic spectrum of phages varied depending on the multilocus sequence type (MLST) of the CRAB isolates. The three phages contained linear double-stranded DNA genomes, with sizes of 41,326-166,741 bp and GC contents of 34.4-35.6%. Genome-wide phylogenetic analysis and single gene-based tree construction revealed no correlation among the three phages. Moreover, no genes were associated with lysogeny, antibiotic resistance, or bacterial toxins. Therefore, the three novel phages represent potential candidates for phage therapy against CRAB infections. | Choi, Yoon-Jung; Kim, Shukho; Shin, Minsang; Kim, Jungmin | Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu 41944, South Korea | ; Kim, Shukho/AGG-1087-2022 | 57220082311; 24341187900; 7401536650; 57211297681 | yjchoi8727@knu.ac.kr;shukhokim@knu.ac.kr;shinms@knu.ac.kr;minkim@knu.ac.kr; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 13 | 7 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2024 | 4.6 | 12.0 | 3.41 | 2025-05-07 | 8 | 6 | bacteriophage; phage therapy; carbapenem-resistant Acinetobacter baumannii (CRAB) | INFECTIONS; PHAGE | bacteriophage; carbapenem-resistant Acinetobacter baumannii (CRAB); phage therapy | carbapenem; RNA 16S; virulence factor; Acinetobacter baumannii; antibiotic resistance; Article; bacteriophage; bacterium identification; bacterium isolation; broth dilution; carbapenem resistant Acinetobacter baumannii; colony forming unit; DNA extraction; electrophoresis; Enterococcus faecalis; Escherichia coli; gene amplification; gene sequence; Klebsiella pneumoniae; microbial diversity; microtiter plate assay; minimum inhibitory concentration; nonhuman; phylogenetic tree; polymerase chain reaction; Pseudomonas aeruginosa; random amplified polymorphic DNA; transmission electron microscopy; virus isolation; whole genome sequencing | English | 2024 | 2024-07 | 10.3390/antibiotics13070610 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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