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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Glycosylated and Succinylated Macrocyclic Lactones with Amyloid-β-Aggregation-Regulating Activity from a Marine Bacillus sp. | Two new glycosylated and succinylated macrocyclic lactones, succinyl glyco-oxydifficidin (1) and succinyl macrolactin O (2), were isolated from a Bacillus strain collected from an intertidal mudflat on Anmyeon Island in Korea. The planar structures of 1 and 2 were proposed using mass spectrometric analysis and NMR spectroscopic data. The absolute configurations of 1 and 2 were determined by optical rotation, J-based configuration analysis, chemical derivatizations, including the modified Mosher's method, and quantum-mechanics-based calculation. Biological evaluation of 1 and 2 revealed that succinyl glyco-oxydifficidin (1) inhibited/dissociated amyloid beta (A beta) aggregation, whereas succinyl macrolactin O (2) inhibited A beta aggregation, indicating their therapeutic potential for disassembling and removing A beta aggregation. | Cui, Jinsheng; Ye, Suhyun; Shin, Daniel; Cho, Illhwan; Kim, Hye Yun; Kwon, Yun; Park, Keunwan; Nam, Sang-Jip; Kim, YoungSoo; Oh, Dong-Chan | Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul 08826, South Korea; Yonsei Univ, Inst Pharmaceut Sci, Coll Pharm, Dept Pharm & Yonsei, Incheon 21983, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Korea Inst Sci & Technol, Nat Prod Informat Res Ctr, Seoul 25451, South Korea; Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea | ; Kim, YoungSoo/AAO-1970-2020; Park, Keunwan/GLS-5403-2022 | 57211542556; 58117086700; 57194555505; 57207768287; 7410136418; 56156932300; 16481120100; 57208839798; 57121191600; 8707854600 | y.kim@yonsei.ac.kr;dongchanoh@snu.ac.kr; | MARINE DRUGS | MAR DRUGS | 1660-3397 | 21 | 2 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2023 | 4.9 | 12.9 | 0.66 | 2025-06-25 | 3 | 3 | glycosylation; succinylation; macrocyclic lactone; absolute configuration; Bacillus sp; amyloid-beta | DRUG DISCOVERY; STEREOCHEMISTRY; MACROLACTINS; INHIBITORS; BACTERIUM | absolute configuration; amyloid-β; Bacillussp; glycosylation; macrocyclic lactone; succinylation | Amyloid beta-Peptides; Bacillus; Lactones; Molecular Structure; amyloid beta protein; DNA 16S; macrolide; amyloid beta protein; lactone; oxydifficidin; ABTS radical scavenging assay; anion exchange chromatography; Article; Bacillus; binding site; biological activity; calculation; carbon nuclear magnetic resonance; chemical analysis; circular dichroism; density functional theory; derivatization; DPPH radical scavenging assay; electrospray mass spectrometry; enzyme active site; fermentation; glycosylation; heteronuclear single quantum coherence; high performance liquid chromatography; high throughput screening; hydrogen bond; IC50; infrared spectroscopy; mass fragmentography; mass spectrometry; molecular docking; molecular dynamics; nonhuman; nuclear magnetic resonance; nucleotide sequence; optical rotation; peptide synthesis; protein aggregation; proton nuclear magnetic resonance; quantum mechanics; sequence analysis; thin layer chromatography; chemical structure; chemistry | English | 2023 | 2023-02 | 10.3390/md21020067 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Krill Oil's Protective Benefits against Ultraviolet B-Induced Skin Photoaging in Hairless Mice and In Vitro Experiments | Krill oil (KO) shows promise as a natural marine-derived ingredient for improving skin health. This study investigated its antioxidant, anti-inflammatory, anti-wrinkle, and moisturizing effects on skin cells and UVB-induced skin photoaging in hairless mice. In vitro assays on HDF, HaCaT, and B16/F10 cells, as well as in vivo experiments on 60 hairless mice were conducted. A cell viability assay, diphenyl-1-picryhydrazyl (DPPH) radical scavenging activity test, elastase inhibition assay, procollagen content test, MMP-1 inhibition test, and hyaluronan production assay were used to experiment on in vitro cell models. Mice received oral KO administration (100, 200, or 400 mg/kg) once a day for 15 weeks and UVB radiation three times a week. L-Ascorbic acid (L-AA) was orally administered at 100 mg/kg once daily for 15 weeks, starting from the initial ultraviolet B (UVB) exposures. L-AA administration followed each UVB session (0.18 J/cm2) after one hour. In vitro, KO significantly countered UVB-induced oxidative stress, reduced wrinkles, and prevented skin water loss by enhancing collagen and hyaluronic synthesis. In vivo, all KO dosages showed dose-dependent inhibition of oxidative stress-induced inflammatory photoaging-related skin changes. Skin mRNA expressions for hyaluronan synthesis and collagen synthesis genes also increased dose-dependently after KO treatment. Histopathological analysis confirmed that krill oil (KO) ameliorated the damage caused by UVB-irradiated skin tissues. The results imply that KO could potentially act as a positive measure in diminishing UVB-triggered skin photoaging and address various skin issues like wrinkles and moisturization when taken as a dietary supplement. | Kim, Jongkyu; Lee, Namju; Chun, Yoon-Seok; Lee, Sang-Hoon; Ku, Sae-Kwang | AriBnC Co Ltd, Yongin 16914, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Surg, Daegu 41566, South Korea; Daegu Haany Univ, Coll Korean Med, Dept Anat & Histol, Gyongsan 38610, South Korea | 37090794500; 55139537400; 57209803368; 58616228600; 7006331005 | jkkim@aribnc.com;namju1210@gmail.com;ceochun@aribnc.com;form23h@knu.ac.kr;gucci200@dhu.ac.kr; | MARINE DRUGS | MAR DRUGS | 1660-3397 | 21 | 9 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2023 | 4.9 | 12.9 | 1.98 | 2025-06-25 | 8 | 9 | krill oil; ultraviolet; skin photoaging; marine-derived ingredients | INDUCED OXIDATIVE STRESS; TOPICAL FORMULATIONS; FISH-OIL; INFLAMMATION; EXTRACT; PROTEIN; ACID | krill oil; marine-derived ingredients; skin photoaging; ultraviolet | Animals; Ascorbic Acid; Collagen; Euphausiacea; Hyaluronic Acid; Mice; Mice, Hairless; Skin; Skin Aging; Ultraviolet Rays; ascorbic acid; caspase 3; collagenase 3; elastase; essential oil; gelatinase B; glutathione; hyaluronic acid; interstitial collagenase; krill oil; malonaldehyde; matrix metalloproteinase; mitogen activated protein kinase p38; phosphoramidon; retinoic acid; superoxide dismutase; transforming growth factor; transforming growth factor beta; unclassified drug; ascorbic acid; collagen; hyaluronic acid; Akt signaling; animal cell; animal experiment; animal model; animal tissue; antiaging activity; antioxidant activity; Article; B16-F10 cell line; bioassay; body weight; cell viability assay; collagen fiber; collagen synthesis; controlled study; cytotoxicity; dermatitis; dietary supplement; DPPH radical scavenging assay; EC50; female; fibroblast cell line; free radical scavenging assay; gas chromatography; gene expression; HaCat cell line; hairless mouse; HDF cell line; histopathology; human; human cell; hyaluronan production assay; IC50; image analysis; immunohistochemistry; immunoreactivity; in vitro study; in vivo study; krill; lipid peroxidation; MAPK signaling; Masson staining; melanoma; microfold cell; microscopy; MMP-1 inhibition test; moisture; mRNA expression level; MTT assay; nonhuman; oxidative stress; photoaging; procollagen content test; protein expression; real time polymerase chain reaction; skin photoaging; skin water loss; ultraviolet B radiation; vapor pressure; wrinkle; animal; cutaneous parameters; hairless mouse; metabolism; mouse; skin; ultraviolet radiation | English | 2023 | 2023-09 | 10.3390/md21090479 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Long-term variations of cloud top patterns associated with heavy rainfall over the Korean peninsula | Study region: Korean peninsula Study focus: Although heavy rainfall systems over Korea were known to be characterized by warm-type heavy rainfall associated with a relatively low cloud top, this feature can vary under climate change. This study primarily investigated the mean climatology and linear trends of heavy rainfall and cloud top distributions over the Korean peninsula. The rainy seasons from June to September for the period of 1983-2021 were analyzed in this study. To understand the climatology and changes of heavy rainfall events, thermodynamic variables and synoptic forcings were analyzed. New hydrological insights for the region: Long-term consistent geostationary satellite data provides a unique opportunity to understand the global cloud variations associated with climate change. This study examined the mean climatology and decadal trends of cloud tops inferred from geo-stationary satellite observations, along with heavy rainfall events over the Korean Peninsula. Rainfall and cloud top heights exhibited a decreasing trend in June, whereas an increase in vigorous deep convection was observed in August/September, mainly in southern Korea. The decadal trends in August and September were associated with large-scale circulation changes, while the trend in September was attributed to increasing typhoon visits over the Korean Peninsula. The cloud top changes, with lowered cloud tops in June and elevated cloud tops in August, suggested a shift of deep convective systems toward the late summer over Korea. | Song, Hwan-Jin | Korea Meteorol Adm, Natl Inst Meteorol Sci, Seoul, South Korea; Kyungpook Natl Univ, Ctr Atmospher Remote Sensing CARE, Dept Atmospher Sci, Daegu, South Korea; Natl Inst Meteorol Sci, Seogwipo Si 63568, Jeju Do, South Korea | Song, Hwan-Jin/M-1641-2018 | 55331697200 | hwanjinsong@gmail.com; | JOURNAL OF HYDROLOGY-REGIONAL STUDIES | J HYDROL-REG STUD | 2214-5818 | 46 | SCIE | WATER RESOURCES | 2023 | 4.7 | 12.9 | 0.86 | 2025-06-25 | 4 | 5 | GridSat; TB11; ERA5; Korea; Rain; Cloud | ASIAN SUMMER MONSOON; INTERANNUAL VARIABILITY; STORM HEIGHT; SEASON; ENVIRONMENT; EVOLUTION; CLUSTERS | Cloud; ERA5; GridSat; Korea; Rain; TB11 | English | 2023 | 2023-04 | 10.1016/j.ejrh.2023.101337 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Machine learning approaches for reconstructing gridded precipitation based on multiple source products | Study region: South Korea is situated in the northeastern region of Asia Study focus:: Recent technological developments have enabled multi-source precipitation products (MSPs), including satellite-based and model-based, to be useful data sources for quantifying the spatiotemporal variations in precipitation. Unfortunately, the main limitation of MSPs in potential applications is inheritance errors with high uncertainty. To tackle this problem, the capabilities of six machine learning algorithms (Ridge Linear Regression, k-Nearest Neighbors, Support Vector Regression, Gradient Boosting Decision Tree, Light Gradient Boosting Machine, and Random Forest) to produce new precipitation product by merging MSPs with ground-based data have investigated. Ground-based data from 2003 to 2017 were utilized for train and valid process. The robustness of the ML algorithms was highlighted using several evaluation metrics such as continuous indices (modified Kling-Gupta Efficiency and root mean square error) and categorical indices (probability of detection, false alarm rate, and critical success index). New hydrological insights for the region: The results indicate that (1) the ML approaches can merge MSPs with observed data for accurately estimate rainfall, particularly in basins with sparsely distributed rain gauge stations. (2) The merged precipitation products generated from the six ML approaches showed significant agreement and high accuracy with observation data considering rainfall intensity estimation and improved the capability of detecting rain and non-rain events over South Korea. | Nguyen, Giang V.; Le, Xuan-Hien; Van, Linh Nguyen; May, Do Thi Tuyet; Jung, Sungho; Lee, Giha | Kyungpook Natl Univ, Dept Adv Sci & Technol Convergence, 2559 Gyeongsang daero, Sangju 37224, South Korea; Kyungpook Natl Univ, Disaster Prevent Emergency Management Inst, 2559 Gyeongsang daero, Sangju 37224, South Korea; Thuyloi Univ, Fac Water Resources Engn, 175 Tay Son, Hanoi 10000, Vietnam | Nguyen, Giang/GQZ-4595-2022; Jung, Sung Ho/ABD-1742-2021; Le, Xuan-Hien/AAZ-9166-2021 | 57297771000; 57209735659; 58045719400; 57969649000; 57209733155; 35069799400 | leegiha@knu.ac.kr; | JOURNAL OF HYDROLOGY-REGIONAL STUDIES | J HYDROL-REG STUD | 2214-5818 | 48 | SCIE | WATER RESOURCES | 2023 | 4.7 | 12.9 | 1.72 | 2025-06-25 | 10 | 10 | Satellite-based precipitation products; Merging; Machine learning; South Korea | SUPPORT VECTOR MACHINE; GEOGRAPHICALLY WEIGHTED REGRESSION; SATELLITE PRECIPITATION; GAUGE OBSERVATIONS; PASSIVE MICROWAVE; NEURAL-NETWORKS; RANDOM FORESTS; RAINFALL DATA; TIME-SERIES; MULTISATELLITE | Machine learning; Merging; Satellite-based precipitation products; South Korea | English | 2023 | 2023-08 | 10.1016/j.ejrh.2023.101475 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents | In recent decades, magnetic nanoparticles (MNPs) have attracted considerable research interest as versatile substances for various biomedical applications, particularly as contrast agents in magnetic resonance imaging (MRI). Depending on their composition and particle size, most MNPs are either paramagnetic or superparamagnetic. The unique, advanced magnetic properties of MNPs, such as appreciable paramagnetic or strong superparamagnetic moments at room temperature, along with their large surface area, easy surface functionalization, and the ability to offer stronger contrast enhancements in MRI, make them superior to molecular MRI contrast agents. As a result, MNPs are promising candidates for various diagnostic and therapeutic applications. They can function as either positive (T-1) or negative (T-2) MRI contrast agents, producing brighter or darker MR images, respectively. In addition, they can function as dual-modal T-1 and T-2 MRI contrast agents, producing either brighter or darker MR images, depending on the operational mode. It is essential that the MNPs are grafted with hydrophilic and biocompatible ligands to maintain their nontoxicity and colloidal stability in aqueous media. The colloidal stability of MNPs is critical in order to achieve a high-performance MRI function. Most of the MNP-based MRI contrast agents reported in the literature are still in the developmental stage. With continuous progress being made in the detailed scientific research on them, their use in clinical settings may be realized in the future. In this study, we present an overview of the recent developments in the various types of MNP-based MRI contrast agents and their in vivo applications. | Tegafaw, Tirusew; Liu, Shuwen; Ahmad, Mohammad Yaseen; Saidi, Abdullah Khamis Ali Al; Zhao, Dejun; Liu, Ying; Nam, Sung-Wook; Chang, Yongmin; Lee, Gang Ho | Kyungpook Natl Univ, Coll Nat Sci, Dept Chem, Taegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Taegu 41944, South Korea | Nam, Sung-Wook/V-5519-2019; Ahmad, Mohammad/AAH-2164-2020 | 55983618600; 57208926248; 57203054570; 57217492867; 57222567792; 57221731093; 16167127700; 7501840633; 7404851841 | tegafawtirusew@yahoo.com;liushuwen0701@gmail.com;yaseen.knu@gmail.com;abdullah_al_saidi@hotmail.com;djzhao.chem@gmail.com;ly1124161@gmail.com;nams@knu.ac.kr;ychang@knu.ac.kr;ghlee@mail.knu.ac.kr; | PHARMACEUTICS | PHARMACEUTICS | 1999-4923 | 15 | 6 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 4.9 | 12.9 | 1.28 | 2025-06-25 | 22 | 24 | magnetic nanoparticle; magnetic resonance imaging; contrast agent; high-performance | IRON-OXIDE NANOPARTICLES; NEPHROGENIC SYSTEMIC FIBROSIS; DUAL CONTRAST; PHOSPHATE NANOPARTICLES; GD2O3 NANOPARTICLES; MRI; T-1; GADOLINIUM; SIZE; RELAXATION | contrast agent; high-performance; magnetic nanoparticle; magnetic resonance imaging | dysprosium; gadolinium; holmium; iron; magnetic nanoparticle; manganese; nuclear magnetic resonance imaging agent; terbium; aqueous solution; biocompatibility; colloid; drug stability; human; hydrophilicity; hydrophobicity; morphology; nonhuman; nuclear magnetic resonance imaging; particle size; Review; T1 weighted imaging; T2 weighted imaging; urinary excretion | English | 2023 | 2023-06 | 10.3390/pharmaceutics15061745 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Molecular detection and assemblage analysis of the intestinal protozoan Giardia duodenalis in wild boars in Korea | Giardia duodenalis (syn. G. intestinalis, G. lamblia) is the only Giardia species that infects humans and most other mammals. Wild boars are a reservoir of many viruses, bacteria, and parasites that can be transmitted to livestock and humans. This study examined the infection rate of G. duodenalis in wild boars and confirmed its specificity by comparing assemblages through PCR amplification of the 18S rRNA, gdh, and beta-giardin genes. Fecal samples were collected from roadkilled or trapped wild boars from April 2016 to December 2021 in Korea. DNA was extracted directly from 612 wild boar fecal specimens using a commercial kit. PCR was performed targeting the 18S rRNA region, beta-giardin, and glutamate dehydrogenase genes of G. duodenalis. Some PCR-positive samples were selected for sequencing analysis. The obtained sequences were subsequently used for phylogenetic tree construction. Of the 612 samples tested, 125 (20.4%) were positive for G. duodenalis. The highest infection rate was detected in the central region (12.0%) and in autumn (12.7%). Among the risk factors, the seasonal factor was statistically significant (p = 0.012). Phylogenetic analysis revealed three genetic assemblages: A, B, and E. Assemblages A and B exhibited 100% identity with Giardia sequences isolated from human and farmed pigs in Korea and Japan. This result cannot be ignored because it indicates the possibility of zoonotic transmission. Therefore, continuous management and monitoring of this pathogen are necessary to prevent transmission and protect animal and human health. | Lee, Haeseung; Kwak, Dongmi | Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea | 57202497862; 7007148758 | dmkwak@knu.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 1.47 | 2025-06-25 | 4 | 4 | genotype; infection rate; phylogenetic analysis; wild boar; Giardia duodenalis | CRYPTOSPORIDIUM; PREVALENCE; REVEALS; IDENTIFICATION; EPIDEMIOLOGY; ANIMALS; HUMANS; CATTLE; CYSTS | genotype; Giardia duodenalis; infection rate; phylogenetic analysis; wild boar | glutamate dehydrogenase; RNA 18S; Article; autumn; controlled study; domestic pig; European wild boar; feces; female; genetic variability; genotyping; Giardia intestinalis; giardiasis; infection rate; Japan; Korea; male; molecular diagnosis; nonhuman; nucleotide sequence; nucleotide sequence; phylogenetic tree; phylogeny; polymerase chain reaction; positivity rate; risk assessment; risk factor; seasonal variation; sensitivity and specificity; summer; zoonotic transmission | English | 2023 | 2023-04-18 | 10.3389/fvets.2023.1139060 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs | Neurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determined using a single-molecule array. Serum NfL concentrations were significantly higher in hypoxemic dogs without neurological signs (n = 6, 175.5 pg/mL) than in healthy dogs (n = 15, 15.9 pg/mL; p < 0.0001). Therefore, neuronal injury should be considered in dogs with hypoxemia caused by cardiopulmonary diseases, even in the absence of neurological signs. | Yun, Taesik; Chae, Yeon; Koo, Yoonhoi; Lee, Dohee; Kim, Hakhyun; Yang, Mhan-Pyo; Kang, Byeong-Teck | Chungbuk Natl Univ, Coll Vet Med, Lab Vet Internal Med, Cheongju 28644, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea | 57209458067; 57215577118; 57220050745; 57226189094; 57192503045; 7404927049; 8858992400 | kangbt@chungbuk.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 0 | 2025-06-25 | 0 | 0 | biomarker; canine; hypoxemia; ischemia; NfL | biomarker; canine; hypoxemia; ischemia; NfL | biological marker; C reactive protein; neurofilament light chain; unclassified drug; animal experiment; animal model; animal tissue; Article; brain hypoxia; cocker spaniel; controlled study; dog; female; hypoxemia; hypoxia; leukocyte; male; mitral valve disease; nerve cell lesion; neurologic disease; nonhuman; oxygen saturation; physical examination; Pomeranian dog; protein blood level; pulmonary hypertension; retrospective study; systolic blood pressure; Yorkshire terrier | English | 2023 | 2023-10-12 | 10.3389/fvets.2023.1284306 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Prevalence and characteristics of foodborne pathogens from slaughtered pig carcasses in Korea | The introduction of bacteria into slaughterhouses can lead to microbial contamination in carcasses during slaughter, and the initial level of bacteria in carcasses is important because it directly affects spoilage and the shelf life. This study was conducted to investigate the microbiological quality, and the prevalence of foodborne pathogens in 200 carcasses from 20 pig slaughterhouses across Korea. Distribution of microbial counts were significantly higher for aerobic bacteria at 3.01-4.00 log(10) CFU/cm(2) (42.0%) and 2.01-3.00 log(10) CFU/cm(2) (28.5%), whereas most of Escherichia coli showed the counts under 1.00 log(10) CFU/cm(2) (87.0%) (P < 0.05). The most common pathogen isolated from 200 carcasses was Staphylococcus aureus (11.5%), followed by Yersinia enterocolitica (7.0%). In total, 17 S. aureus isolates from four slaughterhouses were divided into six pulsotypes and seven spa types, and showed the same or different types depending on the slaughterhouses. Interestingly, isolates from two slaughterhouses carried only LukED associated with the promotion of bacterial virulence, whereas, isolates from two other slaughterhouses carried one or more toxin genes associated with enterotoxins including sen. In total, 14 Y. enterocolitica isolates from six slaughterhouses were divided into nine pulsotypes, 13 isolates belonging to biotype 1A or 2 carried only ystB, whereas one isolate belonging to bio-serotype 4/O:3 carried both ail and ystA. This is the first study to investigate microbial quality and the prevalence of foodborne pathogens in carcasses from slaughterhouses nationally, and the findings support the need for ongoing slaughterhouse monitoring to improve the microbiological safety of pig carcasses. | Hong, Serim; Kang, Hye Jeong; Lee, Hye-Young; Jung, Hye-Ri; Moon, Jin-San; Yoon, Soon-Seek; Kim, Ha-Young; Lee, Young Ju | Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Kyungpook Natl Univ, Zoonoses Res Inst, Daegu, South Korea; Anim & Plant Quarantine Agcy, Bacterial Dis Div, Gimcheon, South Korea | Lee, Hye-Young/JEP-8044-2023 | 58193736900; 57208791752; 58193550600; 57265190900; 57212516440; 9838890500; 53877655700; 56612134500 | kimhy@korea.kr;youngju@knu.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 1.47 | 2025-06-25 | 5 | 4 | foodborne pathogen; pig; carcass; slaughterhouse; microbial quality | RESISTANT STAPHYLOCOCCUS-AUREUS; MICROBIOLOGICAL BASE-LINE; MEAT PROCESSING PLANT; YERSINIA-ENTEROCOLITICA; CLOSTRIDIUM-PERFRINGENS; MULTIPLEX PCR; YSTB GENES; SALMONELLA; STRAINS; CAMPYLOBACTER | carcass; foodborne pathogen; microbial quality; pig; slaughterhouse | enterotoxin; aerobic bacterium; animal experiment; Article; bacterial count; bacterial virulence; bacterium isolate; biotype; carcass; controlled study; Escherichia coli; foodborne pathogen; Korea; microbial contamination; molecular phylogeny; nonhuman; phylogenetic tree; pig; prevalence; slaughterhouse; slaughtering; Staphylococcus aureus; Yersinia enterocolitica | English | 2023 | 2023-03-31 | 10.3389/fvets.2023.1158196 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Production of Ethyl-agarobioside, a Novel Skin Moisturizer, by Mimicking the Alcoholysis from the Japanese Sake-Brewing Process | Agarobiose (AB; d-galactose-& beta;-1,4-AHG), produced by one-step acid hydrolysis of agarose of red seaweed, is considered a promising cosmetic ingredient due to its skin-moisturizing activity. In this study, the use of AB as a cosmetic ingredient was found to be hampered due to its instability at high temperature and alkaline pH. Therefore, to increase the chemical stability of AB, we devised a novel process to synthesize ethyl-agarobioside (ethyl-AB) from the acid-catalyzed alcoholysis of agarose. This process mimics the generation of ethyl & alpha;-glucoside and glyceryl & alpha;-glucoside by alcoholysis in the presence of ethanol and glycerol during the traditional Japanese sake-brewing process. Ethyl-AB also showed in vitro skin-moisturizing activity similar to that of AB, but showed higher thermal and pH stability than AB. This is the first report of ethyl-AB, a novel compound produced from red seaweed, as a functional cosmetic ingredient with high chemical stability. | Lee, Sun-Hee; Yun, Eun Ju; Han, Na Ree; Jung, Inho; Pelton, Jeffrey G.; Lee, Jae-Eun; Kang, Nam Joo; Jin, Yong-Su; Kim, Kyoung Heon | Korea Univ, Grad Sch, Dept Biotechnol, Seoul 02841, South Korea; Jeonbuk Natl Univ, Div Biotechnol, Iksan 54596, South Korea; Korea Forestry Promot Inst, Daejeon 34215, South Korea; Univ Calif Berkeley, Inst QB3, Berkeley, CA 94720 USA; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Catholic Univ Korea, Dept Biotechnol, Bucheon 14662, South Korea; Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA | Jin, Yong-Su/L-4530-2013; Kim, Kyoung Heon/F-1059-2013; Kim, Kyoung/F-1059-2013 | 55989536100; 57908444000; 57225150525; 57205610025; 7006602658; 57203144423; 59775424800; 57204009076; 34770896300 | ejyun@jbnu.ac.kr;wind9887@hanmail.net;jgpelton@berkeley.edu;lju1033@naver.com;njkang@catholic.ac.kr;ysjin@illinois.edu;khekim@korea.ac.kr; | MARINE DRUGS | MAR DRUGS | 1660-3397 | 21 | 6 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2023 | 4.9 | 12.9 | 0.22 | 2025-06-25 | 1 | 1 | ethyl-agarobioside; agarobiose; alcoholysis; agarose; red seaweed; moisturizer | ALPHA-D-GLUCOSIDE; D-GLUCOSYLGLYCEROL; AGAROSE; ACID; OLIGOSACCHARIDES; IDENTIFICATION; TEMPERATURE; MACROALGAE; RESOURCE; AGARASE | agarobiose; agarose; alcoholysis; ethyl-agarobioside; moisturizer; red seaweed | Alcoholic Beverages; Fermentation; Glucosides; Seaweed; Sepharose; agarose; alcohol; cosmetic; ethyl agarobioside; glucoside; glycerol; unclassified drug; sepharose; alcoholysis; Article; brewing; catalysis; chemical reaction; controlled study; high temperature; human; human cell; hydrolysis; in vitro study; moisture; pH; sake; seaweed; skin; synthesis; thermostability; alcoholic beverage; chemistry; fermentation | English | 2023 | 2023-06 | 10.3390/md21060341 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Situational analysis on fluoroquinolones use and characterization of high-level ciprofloxacin-resistant Enterococcus faecalis by integrated broiler operations in South Korea | Fluoroquinolones are classified as "critically important antimicrobials for human medicine"; however, their extensive use in livestock poses a significant health risk to humans as it leads to the rapid spread of antimicrobial resistance. This study confirmed that 40.0%-71.4% of the farms in three of the five integrated broiler operations were administered ciprofloxacin (CIP). Moreover, preventive purposes (60.9%), veterinarian prescriptions (82.6%), drinking water route (100%), and 1 to 3 days (82.6%) of age were significantly highest (P = 512 for both CIP and moxifloxacin was significantly higher in CIP-administered farms (56.5%) than in non-CIP-administered farms (41.4%) (P < 0.05). Also, the prevalence of strong or moderate biofilm formers in HLCR E. faecalis was significantly higher than that of weak and no biofilm formers (P < 0.05). HLCR E. faecalis were heavily distributed in the broiler farms in Korea; therefore, it is necessary to minimize the prevalence of resistant bacteria via structural management regulations such as cleaning and disinfection of farm environments. | Lee, Yu Jin; Jung, Hye-Ri; Yoon, Sunghyun; Lim, Suk-Kyung; Lee, Young Ju | Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Kyungpook Natl Univ, Zoonoses Res Inst, Daegu, South Korea; US FDA, Natl Ctr Toxicol Res, Div Microbiol, Jefferson, AR USA; Anim & Plant Quarantine Agcy, Bacterial Dis Div, Gimcheon, Gyeongsangbuk, South Korea | Yoon, Sunghyun/AAL-4806-2021 | 57352999000; 57265190900; 57216037473; 35086548900; 56612134500 | youngju@knu.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 1.1 | 2025-06-25 | 3 | 3 | high level ciprofloxacin resistance; Enterococcus faecalis; broiler; Korea; biofilm; antimicrobial resistance genes; multidrug resistance; mutation | II TOPOISOMERASE MUTATIONS; ANTIMICROBIAL RESISTANCE; GENES; FAECIUM; IDENTIFICATION; INFECTIONS; MECHANISMS; HUMANS; FARMS; PIGS | antimicrobial resistance genes; biofilm; broiler; Enterococcus faecalis; high level ciprofloxacin resistance; Korea; multidrug resistance; mutation | ampicillin; chloramphenicol; ciprofloxacin; DNA topoisomerase (ATP hydrolysing) A; doxycycline; drinking water; erythromycin; moxifloxacin; penicillin derivative; protein ParC; quinolone derivative; rifampicin; rifamycin; RNA polymerase beta subunit; tetracycline; vancomycin; veterinary drug; agricultural land; animal tissue; Article; bacterial gene; bacterium identification; bacterium isolate; biofilm; broiler; catA gene; chicken meat; ciprofloxacin resistance; controlled study; disk diffusion; Enterococcus faecalis; ermB gene; minimum inhibitory concentration; nonhuman; prescription; qnrA gene; qnrB gene; qnrD gene; South Korea; tetM gene; veterinarian | English | 2023 | 2023-04-03 | 10.3389/fvets.2023.1158721 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Successful treatment of idiopathic tetanus using metronidazole, magnesium, and acepromazine in Hanwoo (Korean indigenous cattle) yearling bull | Bovine tetanus is a serious infectious disease of the central nervous system caused by the exotoxin produced by Clostridium tetani and is characterized by persistent tension and spasm of the rhabdomyocytes. Currently, many studies have focused on diagnosing tetanus; however, only a few studies on treatment methods have been conducted. Therefore, cattle with tetanus have been treated using symptomatic therapy. In this case, severe muscle spasticity and spasms were observed in a 9-month-old Hanwoo (Korean indigenous cattle) bull, and aspartate aminotransferase and creatine kinase levels were increased in serum biochemical tests. Clinically, bovine tetanus was strongly suspected, and metronidazole was administered orally for 5 days. To treat the intensifying bloat, a temporary rumenostomy was performed on the third day of onset, and the toxin gene (tetanospasmin) of C. tetani was amplified by polymerase chain reaction analysis from the collected ruminal fluid. Magnesium and sedatives (acepromazine) were administered for 7 days to treat muscle spasticity and spasms. Muscle spasticity and spasm markedly improved, and the bull stood up from the lateral recumbent position. On the 17(th) day after onset, all tetanus-related symptoms resolved and a normal diet was started. Our findings demonstrated that treatment with metronidazole, magnesium, and acepromazine was effective in the bull with tetanus. | Kim, Youngjun; Ku, Ji-Yeong; Lee, Kichan; Moon, Bo-Youn; Ha, Seungmin; Choi, Kyoung-Seong; Park, Jinho | Jeonbuk Univ, Coll Vet Med, Dept Vet Internal Med, Iksan, South Korea; NongHyup Agribusiness Grp Inc, Hanwoo Genet Improvement Ctr, Dept Anim Hosp, Seosan, South Korea; Anim & Plant Quarantine Agcy, Anim Dis Diagnost Div, Gimcheon, South Korea; Natl Inst Anim Sci Rural Dev Adm, Dept Anim Resource Dev, Dairy Sci Div, Cheonan, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Anim Sci & Biotechnol, Sangju, South Korea | Ha, Seungmin/JLM-9299-2023 | 58845436500; 57753895700; 56191094900; 57209452048; 57214258903; 7403949556; 8730126700 | kschoi3@knu.ac.kr;jpark@jbnu.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 0 | 2025-06-25 | 0 | 0 | Hanwoo (Korean indigenous cattle); idiopathic tetanus; metronidazole; magnesium; acepromazine | BOTULISM; SULFATE; GENE | acepromazine; Hanwoo (Korean indigenous cattle); idiopathic tetanus; magnesium; metronidazole | acepromazine; aspartate aminotransferase; creatine kinase; creatinine; exotoxin; hemoglobin; magnesium; magnesium sulfate; metrojyl; metronidazole; phosphorus; procaine penicillin; sedaject; sodium chloride; tetanospasmin; unclassified drug; Article; aspartate aminotransferase blood level; bloating; blood biochemistry; blood cell count; body temperature; breathing rate; bull (bovine); Clostridium tetani; continuous infusion; convulsion; creatine kinase blood level; creatinine blood level; dehydration; disease severity; erythrocyte count; erythrocytosis; gene amplification; heart rate; hemoglobin blood level; hindlimb; idiopathic disease; intensive care; magnesium blood level; mastication; muscle injury; muscle rigidity; muscle spasm; neck muscle; nonhuman; nutrient supply; physical examination; polymerase chain reaction; recumbency; rumen fluid; rumenostomy; salivation; spasticity; tetanus; treatment duration; treatment outcome; urea nitrogen blood level; uremia; yearling | English | 2023 | 2023-03-23 | 10.3389/fvets.2023.1142316 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Swine gut microbiome associated with non-digestible carbohydrate utilization | Non-digestible carbohydrates are an unavoidable component in a pig's diet, as all plant-based feeds contain different kinds of non-digestible carbohydrates. The major types of non-digestible carbohydrates include non-starch polysaccharides (such as cellulose, pectin, and hemicellulose), resistant starch, and non-digestible oligosaccharides (such as fructo-oligosaccharide and xylo-oligosaccharide). Non-digestible carbohydrates play a significant role in balancing the gut microbial ecology and overall health of the swine by promoting the production of short chain fatty acids. Although non-digestible carbohydrates are rich in energy, swine cannot extract this energy on their own due to the absence of enzymes required for their degradation. Instead, they rely on gut microbes to utilize these carbohydrates for energy production. Despite the importance of non-digestible carbohydrate degradation, limited studies have been conducted on the swine gut microbes involved in this process. While next-generation high-throughput sequencing has aided in understanding the microbial compositions of the swine gut, specific information regarding the bacteria involved in non-digestible carbohydrate degradation remains limited. Therefore, it is crucial to investigate and comprehend the bacteria responsible for the breakdown of non-digestible carbohydrates in the gut. In this mini review, we have discussed the major bacteria involved in the fermentation of different types of non-digestible carbohydrates in the large intestine of swine, shedding light on their potential roles and contributions to swine nutrition and health. | Pandey, Sriniwas; Kim, Eun Sol; Cho, Jin Ho; Song, Minho; Doo, Hyunok; Kim, Sheena; Keum, Gi Beom; Kwak, Jinok; Ryu, Sumin; Choi, Yejin; Kang, Juyoun; Lee, Jeong Jae; Kim, Hyeun Bum | Dankook Univ, Dept Anim Resources Sci, Cheonan, South Korea; Chungbuk Natl Univ, Div Food & Anim Sci, Cheongju, South Korea; Chungnam Natl Univ, Div Anim & Dairy Sci, Daejeon, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea | Kim, Hansu/F-5909-2013; Song, Minho/KHW-1844-2024 | 58083401900; 57222336064; 35228467000; 57200569587; 58083338700; 56692184400; 57225220515; 58083433400; 58409622100; 57199930420; 58512702600; 55915465100; 55784908300 | hbkim@dankook.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 1.29 | 2025-06-25 | 11 | 11 | pigs; non-digestible carbohydrates; bacteria; fermentation; nutrition | OUTER-MEMBRANE PROTEINS; DIETARY FIBER; RESISTANT STARCH; POLYSACCHARIDE UTILIZATION; FIBROBACTER-SUCCINOGENES; CELLULOLYTIC BACTERIA; BUTYRATE FORMATION; HUMAN COLON; CELL-WALL; METABOLISM | bacteria; fermentation; non-digestible carbohydrates; nutrition; pigs | carbohydrate; short chain fatty acid; degradation; fermentation; intestine flora; large intestine; nonhuman; pig; Short Survey | English | 2023 | 2023-07-18 | 10.3389/fvets.2023.1231072 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Tandocyclinones A and B, Ether Bridged C-Glycosyl Benz[a]anthracenes from an Intertidal Zone Streptomyces sp. | Two new proton-deficient metabolites, tandocyclinones A and B (1 and 2), were discovered via the chemical profiling of the Streptomyces sp. strain TDH03, which was isolated from a marine sediment sample collected from the intertidal mudflat in Tando Port, the Republic of Korea. The structures of 1 and 2 were elucidated as new ether-bridged C-glycosyl benz[a]anthracenes by using a combination of spectroscopic analyses of ultraviolet (UV) and mass spectrometry (MS) data, along with nuclear magnetic resonance (NMR) spectra, which were acquired in tetrahydrofuran (THF)-d(8) selected after an extensive search for a solvent, resulting in mostly observable exchangeable protons in the H-1 NMR spectrum. Their configurations were successfully assigned by applying a J-based configuration analysis, rotating-frame Overhauser enhancement spectroscopy (ROESY) NMR correlations, chemical derivatization methods based on NMR (a modified version of Mosher's method) and circular dichroism (CD) (Snatzke's method using Mo-2(OAc)(4)-induced CD), as well as quantum-mechanics-based computational methods, to calculate the electronic circular dichroism (ECD). Tandocyclinones A and B (1 and 2) were found to have weak antifungal activity against Trichophyton mentagrophytes IFM40996 with an MIC value of 128 mu g/mL (244 and 265 mu M for 1 and 2, respectively). A further biological evaluation revealed that tandocyclinone A (1) displayed inhibitory activity against Mycobacterium avium (MIC50 = 40.8 mu M) and antiproliferative activity against SNU638 and HCT116 cancer cells, with IC50 values of 31.9 mu M and 49.4 mu M, respectively. | Huynh, Thanh-Hau; Bae, Eun Seo; Heo, Bo Eun; Lee, Jayho; An, Joon Soo; Kwon, Yun; Nam, Sang-Jip; Oh, Ki-Bong; Jang, Jichan; Lee, Sang Kook; Oh, Dong-Chan | Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul 08826, South Korea; Gyeongsang Natl Univ, Res Inst Life Sci, Dept Bio & Med Big Data, BK21 Four Program,Div Life Sci, Jinju 52828, South Korea; Seoul Natl Univ, Coll Agr & Life Sci, Dept Agr Biotechnol, Seoul 08826, South Korea; Seoul Natl Univ, Nat Prod Res Inst, Seoul 08826, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea | An, Joon Soo/NOF-1416-2025 | 57390777800; 57201505396; 57224108621; 57210787122; 57208526859; 56156932300; 57208839798; 7402730322; 24767832200; 36067620500; 8707854600 | 2019-22632@snu.ac.kr;ddol1289@snu.ac.kr;hbo0113@naver.com;jayho@snu.ac.kr;ahnjunsoo@snu.ac.kr;yunkwon@knu.ac.kr;sjnam@ewha.ac.kr;ohkibong@snu.ac.kr;jichanjang@gnu.ac.kr;sklee61@snu.ac.kr;dongchanoh@snu.ac.kr; | MARINE DRUGS | MAR DRUGS | 1660-3397 | 21 | 9 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2023 | 4.9 | 12.9 | 0.22 | 2025-06-25 | 1 | 1 | structure elucidation; Streptomyces sp.; Crews' rule; Mosher's method; Snatzke's method; Mycobacterium avium; antiproliferative activity | ABSOLUTE-CONFIGURATION; NATURAL-PRODUCTS; CIRCULAR-DICHROISM; NMR DATA; BIOSYNTHESIS; ASSIGNMENT; 1,2-DIOLS | antiproliferative activity; Crews’ rule; Mosher’s method; Mycobacterium avium; Snatzke’s method; Streptomycessp; structure elucidation | C-GlycosylBenz[a]anthracene; chemicals and drugs; clarithromycin; ether; Tandocyclinones A; Tandocyclinones B; tetrahydrofuran; unclassified drug; acetylation; antibacterial activity; antifungal activity; antiproliferative activity; Article; bacterial growth; bacterium isolation; cancer cell; cell proliferation; circular dichroism; column chromatography; controlled study; density functional theory; diastereoisomer; electronic circular dichroism; electrospray mass spectrometry; Enterococcus faecalis; Enterococcus faecium; Escherichia coli; flow rate; HCT 116 cell line; heteronuclear single quantum coherence; high performance liquid chromatography; human; human cell; IC50; Klebsiella pneumoniae; mass spectrometry; MDA-MB-231 cell line; minimum inhibitory concentration; Mycobacterium avium; nuclear magnetic resonance spectroscopy; proton nuclear magnetic resonance; quantum mechanics; rotating-frame Overhauser enhancement spectroscopy; Salmonella enterica; SNU-638 cell line; spectroscopy; Streptomyces; Streptomyces hyderabadensis; Trichophyton mentagrophytes; Trichophyton rubrum; ultraviolet radiation | English | 2023 | 2023-09 | 10.3390/md21090500 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Towards an efficient streamflow forecasting method for event-scales in Ca River basin, Vietnam | Study region: The Ca River basin is located in the North Central Coast area of Vietnam Study focus: This study aims to develop a deep learning framework that is both effective and straightforward in order to forecast water levels in the Ca River basin in advance of multiple time steps for the event scales. We have thoroughly studied and assessed two deep learning models (DLMs), long-short term memory (LSTM) and gated recurrent unit (GRU), for their capacity to forecast water levels, focusing on various aspects such as the influence of sequence length or the impact of hyperparameter selection. Besides, two data scenarios were established using hydrological data from eight severe floods between 2007 and 2019 to examine the effect of input variables on model performance. Water level data was employed for both the scenarios (S1 and S2), whereas precipitation data was used only in S2. The cross-validation technique was used dynamically to address the issue of limited data. The inputs were reformatted as tensors and were then randomly divided into subsets. This flexible tuning preserved the sequential nature of the hydrological data while enabling the DLMs to be trained efficiently. New hydrological insights for the region: The findings revealed that both the models exhibited equally excellent performances. The NSE of the LSTM model varies from 0.999-0.971 compared to 0.998-0.974 of the GRU model, corresponding to forecast cases from one to four-time steps ahead. This indicated that the use of multiple-input data types (S2) contrary to only one date type (S1) does not necessarily improve the forecasting performance. LSTM/GRU models with one hidden layer are adequate for delivering high performance while minimizing the data processing time. | Le, Xuan-Hien; Van, Linh Nguyen; V. Nguyen, Giang; Nguyen, Duc Hai; Jung, Sungho; Lee, Giha | Kyungpook Natl Univ, Disaster Prevent Emergency Management Inst, 2559 Gyeongsang, Sangju 37224, South Korea; Thuyloi Univ, Fac Water Resources Engn, 175 Tay Son, Hanoi 10000, Vietnam; Kyungpook Natl Univ, Dept Adv Sci & Technol Convergence, 2559 Gyeongsang, Sangju 37224, South Korea | Nguyen, Hai/AAD-8210-2020; Nguyen, Giang/GQZ-4595-2022; Le, Xuan-Hien/AAZ-9166-2021 | 57209735659; 57297359100; 57297771000; 57215097506; 57209733155; 35069799400 | leegiha@knu.ac.kr; | JOURNAL OF HYDROLOGY-REGIONAL STUDIES | J HYDROL-REG STUD | 2214-5818 | 46 | SCIE | WATER RESOURCES | 2023 | 4.7 | 12.9 | 1.55 | 2025-06-25 | 9 | 9 | Ca River basin; Cross-validation; Extreme flood; LSTM; GRU | FLOOD RISK | Ca River basin; Cross-validation; Extreme flood; GRU; LSTM | English | 2023 | 2023-04 | 10.1016/j.ejrh.2023.101328 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A Novel Approach to Quantitative Characterization and Visualization of Color Fading | Color fading naturally occurs with time under light illumination. It is triggered by the high photon energy of light. The rate of color fading and darkening depends on the substance, lighting condition, and storage conditions. Color fading is only observed after some time has passed. The current color of objects of interest can only be compared with old photographs or the observer's perception at the time of reference. Color fading and color darkening rates between two or more points in time in the past can only be determined using photographic images from the past. For objective characterization of color difference between two or more different times, quantification of color in either digital or printed photographs is required. A newly developed image analysis and comparison software (PicMan) has been used for color quantification and pixel-by-pixel color difference mapping in this study. Images of two copies of Japanese wood-block prints with and without color fading have been selected for the exemplary study of quantitative characterization of color fading and color darkening. The fading occurred during a long period of exposure to light. Pixel-by-pixel, line-by-line, and area-by-area comparisons of color fading and darkening between two images were very effective in quantifying color change and visualization of the phenomena. RGB, HSV, CIE L*a*b* values between images and their differences of a single pixel to areas of interest in any shape can be quantified. Color fading and darkening analysis results were presented in numerical, graphical, and image formats for completeness. All formats have their own advantages and disadvantages over the other formats in terms of data size, complexity, readability, and communication among parties of interest. This paper demonstrates various display options for color analysis, a summary of color fading, or color difference among images of interest for practical artistic, cultural heritage conservation, and museum applications. Color simulation for various moments in time was proposed and demonstrated by interpolation or extrapolation of color change between images, with and without color fading, using PicMan. The degree of color fading and color darkening over the various moments in time (past and future) can be simulated and visualized for decision-making in public display, storage, and restoration planning. | Yoo, Woo Sik; Kang, Kitaek; Kim, Jung Gon; Yoo, Yeongsik | WaferMasters Inc, Dublin, CA 94568 USA; Kyungpook Natl Univ, Inst Humanities Studies, Daegu 41566, South Korea; Dankook Univ, Coll Liberal Arts, Yongin 16890, South Korea | 55665974300; 9638686700; 48161606000; 57205391310 | woosik.yoo@wafermasters.com;kitaek.kang@wafermasters.com;junggon.kim@wafermasters.com;ysyoophd@dankook.ac.kr; | TECHNOLOGIES | TECHNOLOGIES | 2227-7080 | 11 | 4 | ESCI | ENGINEERING, MULTIDISCIPLINARY | 2023 | 4.2 | 13.0 | 0.53 | 2025-06-25 | 2 | 3 | color fading; color quantification; color difference; image analysis; statistical analysis; software; pixel-by-pixel color difference mapping | SONG-OF-ENLIGHTENMENT; METAL-TYPE; KOREA; IDENTIFICATION; PIGMENT; IMAGES; FADE | color difference; color fading; color quantification; image analysis; pixel-by-pixel color difference mapping; software; statistical analysis | English | 2023 | 2023-08 | 10.3390/technologies11040108 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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