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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Exploration of predictors of benefit from nivolumab monotherapy for patients with pretreated advanced gastric and gastroesophageal junction cancer: post hoc subanalysis from the ATTRACTION-2 study | Background The phase 3 ATTRACTION-2 study demonstrated that nivolumab monotherapy was superior to placebo for patients with pretreated advanced gastric or gastroesophageal junction cancer, but early progression of tumors in some patients was of concern. Methods This post hoc analysis statistically explored the baseline characteristics of the ATTRACTION-2 patients and extracted a single-factor and double-factor combinations associated with early disease progression or early death. In the extracted patient subgroups, the 3-year restricted mean survival times of progression-free survival and overall survival were compared between the nivolumab and placebo arms. Results Two single factors (age and peritoneal metastasis) were extracted as independent predictors of early progression, but none of them, as a single factor, stratified patients into two subgroups with significant differences in restricted mean survival time. In contrast, two double-factor combinations (serum sodium level and white blood cell count; serum sodium level and neutrophil-lymphocyte ratio) stratifying patients into two subgroups with significant differences in the restricted mean survival time were extracted. Additional exploratory analysis of a triple-factor combination showed that patients aged = 60 years with no peritoneal metastasis and normal serum sodium levels might receive higher benefit. Conclusions A combination of age, peritoneal metastasis, and serum sodium level might predict benefit from nivolumab as salvage therapy in advanced gastric or gastroesophageal junction cancer patients, especially less benefit for patients having all three risk factors. | Kang, Yoon-Koo; Morita, Satoshi; Satoh, Taroh; Ryu, Min-Hee; Chao, Yee; Kato, Ken; Chung, Hyun Cheol; Chen, Jen-Shi; Muro, Kei; Kang, Won Ki; Yeh, Kun-Huei; Yoshikawa, Takaki; Oh, Sang Cheul; Bai, Li-Yuan; Tamura, Takao; Lee, Keun-Wook; Hamamoto, Yasuo; Kim, Jong Gwang; Chin, Keisho; Oh, Do-Youn; Minashi, Keiko; Cho, Jae Yong; Tsuda, Masahiro; Sameshima, Hiroki; Chen, Li-Tzong; Boku, Narikazu | Univ Ulsan, Asan Med Ctr, Dept Oncol, Coll Med, Seoul, South Korea; Kyoto Univ, Dept Biomed Stat & Bioinformat, Grad Sch Med, Kyoto, Japan; Osaka Univ, Frontier Sci Canc & Chemotherapy, Grad Sch Med, Suita, Osaka, Japan; Taipei Vet Gen Hosp, Dept Oncol, Taipei, Taiwan; Natl Canc Ctr, Div Gastrointestinal Med Oncol, Tokyo, Japan; Yonsei Univ, Yonsei Canc Ctr, Dept Internal Med, Coll Med, Seoul, South Korea; Chang Gung Univ, Linkou Chang Gung Mem Hosp, Dept Internal Med, Div Hematol & Oncol, Taoyuan, Taiwan; Aichi Canc Ctr Hosp, Dept Clin Oncol, Nagoya, Aichi, Japan; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Hematol Oncol,Sch Med, Seoul, South Korea; Natl Taiwan Univ Hosp, Dept Oncol, Taipei, Taiwan; Kanagawa Canc Ctr, Dept Gastrointestinal Surg, Yokohama, Kanagawa, Japan; Korea Univ, Coll Med, Dept Internal Med, Div Hematol & Oncol, Seoul, South Korea; China Med Univ, China Med Univ Hosp, Dept Internal Med, Div Hematol & Oncol, Taichung, Taiwan; Kindai Univ, Fac Med, Dept Med Oncol, Osakasayama, Japan; Seoul Natl Univ, Coll Med, Dept Internal Med, Div Hematol & Oncol,Bundang Hosp, Seongnam, South Korea; Keio Univ, Keio Canc Ctr, Sch Med, Tokyo, Japan; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Japanese Fdn Canc Res, Dept Gastroenterol, Canc Inst Hosp, Tokyo, Japan; Seoul Natl Univ, Grad Sch, Integrated Major Innovat Med Sci, Coll Med,Canc Res Inst,Seoul Natl Univ Hosp, Seoul, South Korea; Chiba Canc Ctr, Dept Clin Trial Promot, Chiba, Japan; Yonsei Univ, Gangnam Severance Hosp, Dept Med Oncol, Coll Med, Seoul, South Korea; Hyogo Canc Ctr, Dept Gastroenterol Oncol, Akashi, Hyogo, Japan; Ono Pharmaceut Co Ltd, Med Affairs, Osaka, Japan; Natl Hlth Res Inst, Natl Inst Canc Res, Tainan, Taiwan; Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Kaohsiung, Taiwan; Natl Canc Ctr, Dept Gastr Surg, Tokyo, Japan; Kindai Univ, Dept Med Oncol, Nara Hosp, Ikoma, Japan | ; Hamamoto, Yasuo/AAA-9941-2022; Chen, Jen-Shi/GLV-3349-2022; Yeh, Kun-Huei/HGD-3316-2022; Chung, Hyun Cheol/AFB-8969-2022; Kang, Yoon-Koo/ABL-4264-2022; Satoh, Taroh/AAF-5193-2021; Yoshikawa, Takaki/Y-1580-2019 | 7402784198; 7402168212; 12040860900; 7101754860; 7402865850; 56502463000; 7404006815; 35075804900; 7006195808; 7202402198; 7201438906; 7402718437; 55647062500; 7201957490; 7403453308; 35205887300; 7103060946; 59501049300; 7202995470; 8836932000; 6506466850; 58688448700; 56012668900; 57212550493; 7409440415; 55359026700 | ykkang@amc.seoul.kr; | GASTRIC CANCER | GASTRIC CANCER | 1436-3291 | 1436-3305 | 25 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;ONCOLOGY | 2022 | 7.4 | 17.6 | 1.41 | 2025-06-25 | 13 | 14 | Gastric cancer; Gastroesophageal junction; Nivolumab; Early progression; Benefit predictors | BIOMARKERS; SURVIVAL; INDUCTION; RATIO | Benefit predictors; Early progression; Gastric cancer; Gastroesophageal junction; Nivolumab | Antineoplastic Agents, Immunological; Esophageal Neoplasms; Esophagogastric Junction; Humans; Middle Aged; Nivolumab; Stomach Neoplasms; chloride; lactate dehydrogenase; nivolumab; placebo; sodium; immunological antineoplastic agent; nivolumab; adult; age; aged; Article; chloride blood level; controlled study; double blind procedure; esophagus cancer; exploratory research; gastroesophageal junction cancer; gastroesophageal junction cancer; human; Kaplan Meier method; lactate dehydrogenase blood level; leukocyte count; liver metastasis; major clinical study; mean survival time; monotherapy; multicenter study; neutrophil lymphocyte ratio; overall survival; peritoneum metastasis; phase 3 clinical trial; post hoc analysis; progression free survival; randomized controlled trial; restricted mean survival time; sodium blood level; stomach cancer; esophagus tumor; gastroesophageal junction; middle aged; pathology; stomach tumor | English | 2022 | 2022-01 | 10.1007/s10120-021-01230-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Genetic and Molecular Characterization of a New EMS-Induced Mutant without the Third Glucose Moiety at the C-3 Sugar Chain of Saponin in Glycine max (L.) Merr. | Saponin, a secondary metabolite, is produced by various plant species, including soybean (Glycine max (L.) Merr.). Soybeans synthesize triterpenoid saponins, which are classified by their aglycone structure and sugar chain composition. Here, we characterized an ethyl methanesulfonate-induced mutant, PE1539, without saponin and with a glucose moiety at the third position of the C-3 sugar chain. The saponin phenotype of PE1539 is described by the accumulation of Ab-gamma g saponin and deficiency of Ab-alpha g saponin and DDMP-alpha g saponin, similar to a previously reported sg-3 mutant in soybean. Genetic analysis showed that the saponin phenotype of PE1539 is controlled by a recessive mutation. We mapped the gene responsible for the phenotype of PE1539 and the mapped region included Sg-3 (Glyma.10G104700). Further analysis of Sg-3 in PE1539 using DNA sequencing revealed a single-nucleotide substitution in the exon (G804A), resulting in a premature stop codon; thus, PE1539 produced a PSPG box-truncated protein. Saponin phenotype analysis of the F-2 population-from a cross between wild-type Uram and PE1539-showed that the phenotype of saponin was cosegregated with the genotype of Sg 3. Quantitative real-time PCR showed reduced expression of Sg-3 in PE1539 cells. Together, our data indicate that the saponin phenotype of PE1539 results from a mutation in Sg-3. | Ko, Jeongyun; Sundaramoorthy, Jagadeesh; Tsukamoto, Chigen; Park, Junbeom; Lee, Jinwon; Jo, Hyun; Lee, Jeong-Dong; Seo, Hak Soo; Song, Jong Tae | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Swedish Univ Agr Sci, Dept Plant Breeding, S-23053 Alnarp, Sweden; Iwate Univ, Fac Agr, 3-18-8 Ueda, Morioka, Nagano 0208550, Japan; Seoul Natl Univ, Dept Agr Forestry & Bioresources, Seoul 08826, South Korea | Sundaramoorthy, Jagadeesh/O-4027-2017 | 57816460900; 56444549800; 6603711026; 57816147100; 57210899223; 57194539358; 40462075100; 26642769200; 57797134000 | audrynv98@knu.ac.kr;jagadeesh@slu.se;chigen@iwate-u.ac.jp;junfan59@knu.ac.kr;jwlee2018@knu.ac.kr;johyun@knu.ac.kr;jdlee@knu.ac.kr;seohs@snu.ac.kr;jtsong68@knu.ac.kr; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 12 | 7 | SCIE | AGRONOMY;PLANT SCIENCES | 2022 | 3.7 | 17.6 | 0.34 | 2025-06-25 | 2 | 3 | soybean; saponin; saponin phenotype; Sg-3; UDP-glycosyltransferase | MESSENGER-RNAS; STRUCTURAL ELUCIDATION; TRITERPENOID SAPONINS; SOYASAPONINS; MACROAUTOPHAGY; DEGRADATION; INDUCTION; DECAY | saponin; saponin phenotype; Sg-3; soybean; UDP-glycosyltransferase | English | 2022 | 2022-07 | 10.3390/agronomy12071598 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Genome-Wide Association Mapping for Seed Weight in Soybean with Black Seed Coats and Green Cotyledons | The yield of soybean (Glycine max (L.) Merr.) is based on several components, such as the number of plants per unit area, pod number per plant, number of nodes, and seed weight. Additionally, the hundred-seed weight (HSW) is an important component affecting soybean yield. The HSW trait can determine soy products meant for human consumption. In this study, we conducted genome-wide association studies with 470 accessions of black seed coats with green cotyledons and applied an online tool with publicly available genome sequencing data. The objective of the study was to identify the genomic regions in the soybean genome associated with seed weight and to identify the candidate genes in linkage disequilibrium blocks where the most significant SNPs were located. This study identified significant SNPs for seed weight on chromosomes 2 and 16. Furthermore, this study indicated that GmCYP78A57 (Glyma.02G119600) encoded a cytochrome P450 monooxygenase may be a possible candidate gene for controlling the seed size in soybean. We assumed that another gene on chromosome 16 may play the important role of a small additive genetic effect to reduce seed size along with GmCYP78A57. An online tool was used to identify 12 allelic variations of GmCYP78A57 with publicly available genomic sequence data. The HSW of 45 accessions having a missense mutation from the Germplasm Resources Information Network ranged from 4.4 to 17.6 g. In addition, 19 accessions were shown to be less than 10.0 g of HSW. This information can provide for the development of molecular markers to use in soybean breeding programs to release new cultivars with increased or decreased seed weight. | Jo, Hyun; Lee, Ji Yun; Lee, Jeong-Dong | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Gyeongsangbuk Do Prov Agr Res & Extens Serv, Daegu 41404, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea | 57194539358; 57223232131; 40462075100 | johyun@knu.ac.kr;dock0409@korea.kr;jdlee@knu.ac.kr; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 12 | 2 | SCIE | AGRONOMY;PLANT SCIENCES | 2022 | 3.7 | 17.6 | 0.79 | 2025-06-25 | 7 | 7 | black soybean; green cotyledon; seed weight; CYP78A; genome sequence | GENETIC ARCHITECTURE; CYTOCHROME P450S; AGRONOMIC TRAITS; GROWTH HABIT; SIZE; YIELD; RICE; IDENTIFICATION; EVOLUTION; SELECTION | Black soybean; CYP78A; Genome sequence; Green cotyledon; Seed weight | English | 2022 | 2022-02 | 10.3390/agronomy12020250 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Increasing the Activity of Sugarcane Sucrose Phosphate Synthase Enhanced Growth and Grain Yields in Transgenic Indica Rice | Sucrose is the primary form of mobile photoassimilates, and its level is regulated by sucrose-phosphate synthase (SPS) in plants. Increasing in the SPS activity was accompanied by an increase in sucrose accumulation. This study was designed to examine the effect of the overexpression sugarcane SoSPS1 gene on sucrose metabolizing enzymes, growth, and grain yield of indica rice. The SoSPS1 gene was constructed in a binary vector under the control of a rice ubiquitin promoter and transformed into indica rice using an Agrobacterium vector. Five lines of transgenic rice were selected to develop homozygous transgenic lines and used for analysis. The overexpression of the SoSPS1 gene significantly increased the transcript and protein levels, followed by increasing in SPS activity and sucrose content in the leaves of the transgenic rice lines. Moreover, the activity of soluble acid invertase (SAI) was elevated rather than sucrose synthase (SuSy) in the transgenic lines. The increase in the sucrose-degrading enzymes leads to an increase in plant growth and development. The plant height and number of tillers were significantly higher in the transgenic line compared to non-transgenic (NT) rice. In addition, the amylose content, the number of seeds per panicle, and the weight of 1000 grains of seed, including dry biomass weight, were increased in the transgenic lines. The results indicated that enhancement of SPS activity, as well as sucrose content, provides a higher carbon partitioning for higher growth and productivity of the transgenic rice lines. | Mulyatama, Reza Anugrah; Neliana, Intan Ria; Sawitri, Widhi Dyah; Sakakibara, Hitoshi; Kim, Kyung-Min; Sugiharto, Bambang | Univ Jember, Grad Sch Biotechnol, Jember 68121, Indonesia; Univ Jember, Ctr Dev Adv Sci & Technol CDAST, Jember 68121, Indonesia; Univ Gadjah Mada, Fac Agr, Dept Agron, Yogyakarta 55281, Indonesia; RIKEN Ctr Sustainable Resource Sci, Yokohama 2300045, Japan; Nagoya Univ, Grad Sch Bioagr Sci, Nagoya 4648601, Japan; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Div Plant Biosci, Daegu 702701, South Korea; Univ Jember, Fac Math & Nat Sci, Dept Biol, Jember 68121, Indonesia | Neliana, Intan/L-4583-2019; Kim, Kyung-Min Kim/C-7007-2014; Sakakibara, Hitoshi/A-6040-2010; Sawitri, Widhi/AFF-4131-2022 | 58032781900; 57205416926; 55247414800; 7102969974; 34868260300; 6602309159 | sugiharto.fmipa@unej.ac.id; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 12 | 12 | SCIE | AGRONOMY;PLANT SCIENCES | 2022 | 3.7 | 17.6 | 1.02 | 2025-06-25 | 9 | 9 | indica rice; sugarcane sucrose phosphate synthase; overexpression; grain yield; Agrobacterium-mediated transformation | PLANT-GROWTH; OVER-EXPRESSION; GENE; METABOLISM; OVEREXPRESSION; LEAVES; ROLES; CO2 | Agrobacterium-mediated transformation; grain yield; indica rice; overexpression; sugarcane sucrose phosphate synthase | English | 2022 | 2022-12 | 10.3390/agronomy12122949 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Institutional case volume-incorporated mortality risk prediction model for cardiac surgery | Background: Most risk prediction models predicting short-term mortality after cardiac surgery incorporate patient characteristics, laboratory data, and type of surgery, but do not account for surgical experience. Considering the impact of case volume on patient outcome after high-risk procedures, we attempted to develop a risk prediction model for mortality after cardiac surgery that incorporates institutional case volume. Methods: Adult patients who underwent cardiac surgery from 2009 to 2016 were identified. Patients who underwent cardiac surgery (n = 57,804) were randomly divided into the derivation cohort (n = 28,902) or the validation cohorts (n = 28,902). A risk prediction model for in-hospital mortality and 1-year mortality was developed from the derivation cohort and the performance of the model was evaluated in the validation cohort. Results: The model demonstrated fair discrimination (c-statistics, 0.76 for in-hospital mortality in both cohorts; 0.74 for 1-year mortality in both cohorts) and acceptable calibration. Hospitals were classified based on case volume into 50 or less, 50-100, 100-200, or more than 200 average cardiac surgery cases per year and case volume was a significant variable in the prediction model. Conclusions: A new risk prediction model that incorporates institutional case volume and accurately predicts in-hospital and 1-year mortality after cardiac surgery was developed and validated. (c) 2021 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/). | Lee, Seohee; Jang, Eun Jin; Jo, Junwoo; Park, Dongnyeok; Ryu, Ho Geol | Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Anesthesiol & Pain Med, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea; Andong Natl Univ, Dept Informat Stat, 1375 Gyeongdong Ro Andong, Gyeongsangbuk Do 36729, South Korea; Kyungpook Natl Univ, Dept Stat, 80 Daehak Ro, Daegu 41566, South Korea | Ryu, Ho/J-5463-2012 | 57199185656; 37861741600; 57210425017; 57223971779; 7202277246 | hogeol73@snu.ac.kr; | ASIAN JOURNAL OF SURGERY | ASIAN J SURG | 1015-9584 | 0219-3108 | 45 | 1 | SCIE | SURGERY | 2022 | 3.5 | 17.6 | 0.41 | 2025-06-25 | 2 | 2 | Case volume; Cardiac surgery; Mortality; Prediction model | IN-HOSPITAL MORTALITY; BYPASS GRAFT-SURGERY; EUROSCORE II; VALVE SURGERY; PERFORMANCE; DATABASE; OUTCOMES; SOCIETY; SYSTEM; REPAIR | Cardiac surgery; Case volume; Mortality; Prediction model | Adult; Cardiac Surgical Procedures; Cohort Studies; Hospital Mortality; Humans; Risk Assessment; Risk Factors; adult; cohort analysis; controlled study; heart surgery; hospital mortality; human; randomized controlled trial; risk assessment; risk factor | English | 2022 | 2022-01 | 10.1016/j.asjsur.2021.04.047 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Investigation of Solanum carolinense Dominance and Phytotoxic Effect in Festuca arundinacea with Special Reference to Allelochemical Identification, Analysis of Phytohormones and Antioxidant Mechanisms | Exposure to invasive weeds in pasturelands may result in significant losses and toxicity in forage crops. These species may also contain a compound that may be toxic as well as beneficial depending upon the effect induced. The Ministry of Environment of the Republic of Korea has now recognized Solanum carolinense (Horsenettle)-an invasive weed species-as a potential threat to forage crops in pasturelands and to the entire agro-ecosystem. As a forage crop, Festuca arundinacea (Tall fescue) is one of the major economical crops and diets of livestock; in this study, the competition patterns of Solanum carolinense and Festuca arundinacea were examined with respect to their seeding ratios and growth periods. In addition, an extract from the root of Solanum carolinense (SCE) was prepared and treated at 2500 ppm and 5000 ppm in a Festuca arundinacea plant to observe its effect. The experimental results showed that as the growth period of the Horsenettle and the SCE treatment increased, the germination rate, plant height, root length, fresh weight, and dry weight of the tall fescue were significantly decreased. Moreover, the SCE treatment significantly increased the quantities of reactive oxygen species (O-2(-) and H2O2), antioxidants (Catalase and Peroxidase), and endogenous phytohormones (Abscisic acid and Salicylic acid), and simultaneously decreased the superoxide dismutase content in the tall fescue shoots. Furthermore, we identified several glycoalkaloids from the SCE extract, among which Solanidan-3-ol, (3 beta,5 alpha)' possessed a higher number (52%). Based on these results, we predicted that the Solanidan-3-ol, (3 beta,5 alpha)' present in horsenettle has a major role in imposing phytotoxicity on agricultural crops. The glycoalkaloids in the Solanum species have been reported to possess both phytotoxic and therapeutic uses. Based on this concept, we believe that the compound available in Solanum carolinense could be used in developing crop protection or medicinal products through broader research. Conversely, our findings also showed the probable risk of horsenettle to the agro-ecosystem, especially in terms of forage production. | Kim, Lee-Rang; Adhikari, Arjun; Kang, Yosep; Gam, Ho-Jun; Kang, Sang-Mo; Kim, Ki-Yong; Lee, In-Jung | Kyungpook Natl Univ, Div Plant Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Rural Dev Adm RDA, Natl Inst Anim Sci, Cheonan 31000, South Korea | ; Lee, In-Jung/GLS-0432-2022; Adhikari, Arjun/AAV-6297-2021; Adhikari, Arjun/JCO-3306-2023; Kang, Sang-Mo/MBG-7823-2025; Gam, Hojun/MXJ-6421-2025 | 57221646797; 57195601415; 57224404010; 57450591400; 56189696900; 57211349597; 16425830900 | ijlee@knu.ac.kr; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 12 | 8 | SCIE | AGRONOMY;PLANT SCIENCES | 2022 | 3.7 | 17.6 | 1.02 | 2025-06-25 | 8 | 9 | bioherbicide; agro-ecosystem; allelochemical; crop protection; forage; sustainable agriculture; stress | TALL FESCUE; SALICYLIC-ACID; GLYCOALKALOIDS; STRESS; ALLELOPATHY; GENERATION; MANAGEMENT; RESISTANCE; HERBICIDES; SYSTEM | agro-ecosystem; allelochemical; bioherbicide; crop protection; forage; stress; sustainable agriculture | English | 2022 | 2022-08 | 10.3390/agronomy12081954 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Microbacterium oxydans Regulates Physio-Hormonal and Molecular Attributes of Solanum lycopersicum under Drought Stress | Among the types of abiotic stresses, drought is one of the most serious growth limiting factors for crop plants. In recent years, various strategies have been employed to alleviate the adverse effects of drought stress in crops, but the use of plant growth-promoting rhizobacteria (PGPR) is among the standout techniques. Currently, we have isolated 55 strains of bacteria from the rhizosphere of Achyranthes aspera L. and Calotropis procera (Aiton). However, AGH3, AGH5, and AGH9 produced significant (p = 0.05) amounts of plant hormones and exhibited siderophore and phosphate solubilization activities. Bioassay experiments on Waito-C rice demonstrated an enhanced growth in the presence of the isolate AGH3. Moreover, the isolate AGH3 promoted the growth of Solynum lycopersicum L. under drought stress. The results revealed that AGH3-associated S. lycopersicum plants showed significantly (p = 0.05) reduced production of abscisic acid (ABA) and jasmonic acid (JA) as compared with the AGH3-free plants under polyethylene glycol (PEG) stress. In addition, high expressions of SlmiR 159 (from 6- to 10-fold), SlHsfA1a (from 1- to 4-fold), and SlHAKT1 (from 0.26- to 1-fold) genes were noticed in AGH3-associated S. lycopersicum plants under drought stress. From the results, it is concluded that rhizobacteria (AGH3) can be used as a pragmatic biofertilizer to ensure organic farming under normal as well as drought conditions. | Siraj, Shumaila; Khan, Muhammad Aaqil; Hamayun, Muhammad; Ali, Sajid; Khan, Sumera Afzal; Hussain, Anwar; Iqbal, Amjad; Khan, Hamayoon; Kang, Sang-Mo; Lee, In-Jung | Abdul Wali Khan Univ, Dept Bot, Garden Campus, Mardan 23200, Pakistan; Univ Peshawar, Ctr Biotechnol & Microbiol, Peshawar 25120, Pakistan; Qurtuba Univ Sci & Informat Technol, Dept Chem & Life Sci, Peshawar 24830, Pakistan; Yeungnam Univ, Dept Hort & Life Sci, Gyongsan 38541, South Korea; Abdul Wali Khan Univ, Dept Agr, Garden Campus, Mardan 23200, Pakistan; Agr Univ, Dept Agron, Peshawar 25130, Pakistan; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu 41566, South Korea | Khan, Shuhab/C-6839-2008; Ali, Sajid/GLS-7322-2022; Hussain, Anwar/N-1605-2019; Kang, Sang-Mo/MBG-7823-2025; Lee, In-Jung/GLS-0432-2022; Iqbal, Amjad/E-2010-2014; Khan, Muhammad/ABB-9797-2021; Hamayun, Muhammad/B-1694-2010 | 57226755080; 57188585606; 59297330100; 57214290889; 9636646900; 35621772200; 10142205100; 22835075000; 56189696900; 16425830900 | hamayun@awkum.edu.pk;sajidbioali@gmail.com;ijlee@knu.ac.kr; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 12 | 12 | SCIE | AGRONOMY;PLANT SCIENCES | 2022 | 3.7 | 17.6 | 1.24 | 2025-06-25 | 8 | 11 | crop plants; rhizobacteria; drought stress; ABA; IAA; JA; gene expression | PLANT-GROWTH; USE EFFICIENCY; ACC DEAMINASE; TOLERANCE; POTASSIUM; IMPROVE; WHEAT; SOIL; L. | ABA; crop plants; drought stress; gene expression; IAA; JA; rhizobacteria | English | 2022 | 2022-12 | 10.3390/agronomy12123224 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Modeling-Based Energy Performance Assessment and Validation of Air-To-Water Heat Pump System Integrated with Multi-Span Greenhouse on Cooling Mode | The purpose of this study was to conduct a modeling-based energy performance assessment and validation of an air-to-water heat pump (AWHP) system, in the cooling mode, integrated with a multi-span greenhouse using TRNSYS software. We used the building energy simulation (BES) model to investigate the performance characteristics of the AWHP system for greenhouse cooling. We modelled the components of the AWHP system, including the fan coil unit (FCU), water storage tank, and water circulation pump integrated with the greenhouse model. The proposed model included all the components of the experimental system. We validated the proposed model by comparing the simulation results with those obtained from field experiments. We investigated the cooling energy supply to the multi-span greenhouse, greenhouse internal air temperature, heat pump (HP) output temperature, and coefficient of performance (COP). We evaluated the performance of our model by calculating the Nash-Sutcliffe efficiency (NSE) coefficient of all the validated components. Furthermore, we performed linear regression analyses (R-2) to determine the relationship between the different parameters. NSE values of 0.87, 0.81, and 0.93, for the greenhouse internal air temperature, the energy supply to the greenhouse, and the HP output water temperature, respectively, validated the prediction accuracy of the model. Moreover, R-2 values of 0.83 and 0.39 indicated that cooling loads are more dependent on ambient solar radiation than ambient air temperature. Furthermore, an R-2 value of 0.91 showed a linear relationship between the HP's energy consumption and ambient air temperature. The average daily COP of the HP system was 2.9. Overall, the simulation results showed acceptable correlation with the experimental results. The high NSE values validated the high predictive power of the model. The proposed validation model can be used to improve the performance of systems by optimizing the control strategies and capacities of the equipment (e.g., the HP, the FCU, and the area of the greenhouse). We have provided detailed information to enable engineers, researchers, and consultants to implement the model for their specific needs. | Rasheed, Adnan; Kim, Hyeon Tae; Lee, Hyun Woo | Kyungpook Natl Univ, Smart Agr Innovat Ctr, Daegu 41566, South Korea; Gyeongsang Natl Univ, Inst Agr & Life Sci, Dept Bioind Machinery Engn, Jinju 52828, South Korea; Kyungpook Natl Univ, Dept Agr Engn, Daegu 41566, South Korea | ; Rasheed, Adnan/ABE-6624-2021 | 56080100700; 8662923200; 57209160180 | adnanrasheed@knu.ac.kr;bioani@gnu.ac.kr;whlee@knu.ac.kr; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 12 | 6 | SCIE | AGRONOMY;PLANT SCIENCES | 2022 | 3.7 | 17.6 | 0.79 | 2025-06-25 | 8 | 8 | TRNSYS simulation; energy analysis; coefficient of performance; greenhouse cooling | SIMULATION | coefficient of performance; energy analysis; greenhouse cooling; TRNSYS simulation | English | 2022 | 2022-06 | 10.3390/agronomy12061374 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Morphological and Biochemical Variation in Carrot Genetic Resources Grown under Open Field Conditions: The Selection of Functional Genotypes for a Breeding Program | Carrot (Daucus carota), one of the most economically important root vegetables, shows a wide range of morphological and biochemical diversity. However, there is a lack of simultaneous systematic study regarding the biochemical composition and morphological characteristics in carrot genetic resources, which is crucial for crop improvement. For this reason, the morphological characteristics, carotenoids, and free sugar content of 180 carrot genetic resources grown in open field conditions from March to June 2020 were accessed to select the lines for a potential breeding program. Altogether, 15 qualitative and 4 quantitative agronomical characteristics were evaluated and grouped into four categories based on root color (orange, yellow, white, and purple). Three carotenoids (lutein, alpha-carotene, and beta-carotene) and three free sugars (fructose, glucose, and sucrose) were also analyzed. The results revealed wide genetic variation in both qualitative and quantitative traits. Most of the genetic resources were orange (n = 142), followed by white (n = 16), yellow (n = 14), and purple (n = 8). Carotenoid profile and content were highly dependent on root color and showed wide genetic variability, while sugar content and profile were independent of the root color. Alpha- and beta- carotene were the major carotenoids in orange carrots representing 43.3 and 41.0% of total carotenoids. In contrast, lutein was most dominant in other colored carrots (79.7-98.6% of total carotenoids). In most of the genetic resources, sucrose was the most dominant free sugar, followed by glucose and fructose. The results of this study showed that some genetic resources elevated carotenoid and sugar content. The morphological and biochemical diversity observed in this study might be useful for improving the agronomic traits and biochemical content of carrot lines for breeding programs. | Bhandari, Shiva Ram; Rhee, Juhee; Choi, Chang Sun; Jo, Jung Su; Shin, Yu Kyeong; Song, Jae Woo; Kim, Seong-Hoon; Lee, Jun Gu | Jeonbuk Natl Univ, Coll Agr & Life Sci, Dept Hort, Jeonju 54896, South Korea; Jeonbuk Natl Univ, Core Res Inst Intelligent Robots, Jeonju 54896, South Korea; Rural Dev Adm, Natl Inst Agr Sci, Natl Agrobiodivers Ctr, Jeonju 54874, South Korea; Koregon Co Ltd, Breeding Res Inst, Gimje 54324, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Hort Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Jeonbuk Natl Univ, Inst Agr Sci & Technol, Jeonju 54896, South Korea | Bhandari, Shiva/T-6564-2019; Kim, Seong-Hoon/AHE-2059-2022 | 55267384000; 56975875600; 56727217500; 57197337268; 57216457847; 57219714695; 57208236056; 57206731878 | shivarbhandari@gmail.com;rheehk@korea.kr;sunlog@naver.com;jjs446@naver.com;milkyway_100@naver.com;thdwodn581@naver.com;shkim0819@korea.kr;jungu@jbnu.ac.kr; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 12 | 3 | SCIE | AGRONOMY;PLANT SCIENCES | 2022 | 3.7 | 17.6 | 1.24 | 2025-06-25 | 12 | 12 | agronomic traits; crop breeding; carotenoids; carrot; genetic resources; root color; sugars | CAROTENOID ACCUMULATION; BETA-CAROTENE; SUGAR CONTENT; COLOR; BIOSYNTHESIS; DEGRADATION; ZEAXANTHIN; NUTRITION; SWEETNESS; TOMATO | Agronomic traits; Carotenoids; Carrot; Crop breeding; Genetic resources; Root color; Sugars | English | 2022 | 2022-03 | 10.3390/agronomy12030553 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | MSE-Based Joint Transceiver and Passive Beamforming Designs for Intelligent Reflecting Surface-Aided MIMO Systems | In this letter, novel schemes for joint transceiver and passive beamforming design in an intelligent reflecting surface (IRS)-aided multiple-input multiple-output (MIMO) system are developed. Specifically, active beamformer at the BS, passive beamfomer at the IRS, and receive filter at the user are jointly optimized based on two realistic mean square error (MSE) criteria for signal estimation: (i) total MSE minimization and (ii) maximum per-stream MSE minimization. To tackle these challenging nonconvex problems effectively, two efficient iterative algorithms are proposed for both MSE criteria, in which the receive filter, active and passive beamformers are designed in alternating manner through solving the corresponding convex subproblems, respectively. Numerical results demonstrate better performance of the proposed schemes compared to baseline schemes in terms of the MSE and error rate performance. | Kang, Jae-Mo; Yun, Sangseok; Kim, Il-Min; Jung, Heechul | Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Informat & Commun Engn, Busan 48513, South Korea; Queens Univ, Dept Elect & Comp Engn, Kingston, ON K7L 3N6, Canada | ; Jung, Heechul/HTL-7199-2023 | 56024930400; 56115729600; 36040390300; 55652175200 | jmkang@knu.ac.kr;ssyun@pknu.ac.kr;ilmin.kim@queensu.ca;heechul@knu.ac.kr; | IEEE WIRELESS COMMUNICATIONS LETTERS | IEEE WIREL COMMUN LE | 2162-2337 | 2162-2345 | 11 | 3 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2022 | 6.3 | 17.6 | 0.76 | 2025-06-25 | 8 | 10 | MIMO communication; Minimization; Transceivers; Array signal processing; Convex functions; Optimization; MISO communication; Intelligent reflecting surface (IRS); mean square error (MSE); passive beamforming; transceiver design | CHANNELS | Intelligent reflecting surface (IRS); Mean square error (MSE); Passive beamforming; Transceiver design | Array processing; Beamforming; Errors; Functions; Mean square error; MIMO systems; Radio transceivers; Convex functions; Intelligent reflecting surface; Mean square error; Means square errors; Minimisation; MISO communication; Multiple-input multiple-output communications; Optimisations; Passive beamforming; Reflecting surface; Transceiver design; Transceiver design.; Iterative methods | English | 2022 | 2022-03 | 10.1109/lwc.2021.3139024 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Novel Allele of FAD2-1A from an EMS-Induced Mutant Soybean Line (PE529) Produces Elevated Levels of Oleic Acid in Soybean Oil | Soybean seed oils contain approximately 23% oleic acid, and elevated amounts of oleic acid help prevent cardiovascular diseases and improve the quality of the oil. Chemically, it helps maintain the oxidative stability of oil; hence, soybean breeders primarily seek to increase its concentration for improved oil quality. As soybean seeds with mutant alleles of FAD2-1A and FAD2-1B genes have been reported to produce approximately 80% of oleic acid, a mutant population was developed from an ethyl methanesulfonate (EMS)-induced soybean cultivar (Pungsannamul). From this, a new mutant allele of FAD2-1A was identified using mutant lines with elevated oleic acid levels and the pooled-DNA sequencing method. This study identified PE529 as the allele with >40% oleic acid carrying the novel allele of the FAD2-1A gene. The single nucleotide polymorphism (SNP) in PE529 also induced the conversion from tryptophan to a premature stop codon at position 293 in the amino acid sequence (W293STOP). The inheritance analysis showed that the elevated oleic acids in PE529 were attributed to the fad2-1a W293STOP allele. In this study, seeds capable of producing approximately 80.0% oleic acid were identified from F-2 populations where fad2-1a W293STOP and fad2-1b alleles were segregated. Hence, soybeans with novel alleles are useful genetic resources to improve soybean oil quality in breeding programs. | Jo, Hyun; Woo, Changwan; Norah, Nabachwa; Song, Jong Tae; Lee, Jeong-Dong | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Food Secur & Agr Dev, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea | 57194539358; 57881884500; 57900959100; 57797134000; 40462075100 | jdlee@knu.ac.kr; | AGRONOMY-BASEL | AGRONOMY-BASEL | 2073-4395 | 12 | 9 | SCIE | AGRONOMY;PLANT SCIENCES | 2022 | 3.7 | 17.6 | 0.57 | 2025-06-25 | 5 | 5 | FAD2-1; high oleic acid oil; EMS; soybean; genetic resource | BRASSICA-NAPUS; SEED OIL; DESATURASE; STABILITY; COMBINATIONS; GENETICS; TRAIT; LOCI | EMS; FAD2-1; genetic resource; high oleic acid oil; soybean | English | 2022 | 2022-09 | 10.3390/agronomy12092115 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Correction | Observational Study of Surface Wind along a Sloping Surface over Mountainous Terrain during Winter (vol 35, pg 276, 2018) | LEE, Young-Hee; LEE, Gyuwon; JOO, Sangwon; AHN, Kwang-Deuk | Kyungpook Natl Univ, Dept Atmospher Sci, Daegu 41566, South Korea; Natl Inst Meteorol Sci, Climate Res Dept, Jejudo 63568, South Korea; Korean Meteorol Adm, Aviat Meteorol Off, Incheon 22382, South Korea | 56812706200; 7404852271; 7101656617; 57189992426 | young@knu.ac.kr; | ADVANCES IN ATMOSPHERIC SCIENCES | ADV ATMOS SCI | 0256-1530 | 1861-9533 | 39 | 10 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2022 | 5.8 | 17.6 | 0 | 2025-06-25 | 0 | 0 | English | 2022 | 2022-10 | 10.1007/s00376-022-2006-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Radiological criteria for selecting candidates for neoadjuvant chemotherapy for gastric cancer: an exploratory analysis from the PRODIGY study | Background In this exploratory analysis from the PRODIGY study, we aimed to define the radiological criteria to identify patients with gastric cancer who may derive maximal clinical benefit from neoadjuvant chemotherapy. Patients and methods There were 246 patients allocated to receive surgery followed by adjuvant S-1 (SC group) and 238 allocated to receive neoadjuvant chemotherapy (CSC group). As the PRODIGY's radiological method of lymph node (LN) evaluation considers short diameter and morphology (the size and morphology method), a method considering only short diameter was also employed. In the SC group, the correlation between radiologic and pathologic findings was analyzed. The hazard ratio (HR) for the progression-free survival (PFS) of the CSC group was analyzed in subgroups with different cT/N stages. Results cT4 disease showed a sensitivity of 85.6% for detecting pT4 and had a low proportion of pathologic stage (pStage) I disease (4.5%). Among the criteria determined by different cT/N stages by each method of LN positivity, those involving cT4Nany or cT4N + by both methods had a minimal proportion of pStage I disease (= 75.9% sensitivity for detecting pStage III disease. The relative risk reduction in PFS of the CSC group was greatest in patients meeting the cT4Nany criterion defined by both methods (HR 0.67, 95% confidence interval 0.48-0.93). Conclusions The cT4Nany criterion, regardless of the radiological method used for LN evaluation, may help select patients with resectable gastric cancer for neoadjuvant chemotherapy. | Kim, Hyung-Don; Lee, Jong Seok; Yook, Jeong Hwan; Ryu, Min-Hee; Park, Young-Kyu; Kim, Jin Young; Kim, Young-Woo; Oh, Sang Cheul; Kim, Jong Gwang; Cheong, Jae-Ho; Jeong, Oh; Noh, Sung Hoon; Kang, Yoon-Koo | Univ Ulsan, Asan Med Ctr, Coll Med, Dept Oncol, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Dept Radiol, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Dept Surg, Seoul, South Korea; Chonnam Natl Univ, Med Sch, Dept Surg, Hwasun, South Korea; Keimyung Univ, Sch Med, Dongsan Med Ctr, Div Hematooncol,Dept Internal Med, Daegu, South Korea; Natl Canc Ctr, Res Inst & Hosp, Grad Sch Canc Sci & Policy, Ctr Gastr Canc, Goyang, South Korea; Korea Univ, Guro Hosp, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Internal Med, Daegu, South Korea; Yonsei Univ, Coll Med, Dept Surg, Seoul 03722, South Korea | Kang, Yoon-Koo/ABL-4264-2022; Kim, Yuriy/ABD-7016-2020; Kim, Sung-Bae/JXL-8219-2024 | 56526231200; 59699991100; 7006991559; 7101754860; 10140547300; 57196169650; 57215377843; 55647062500; 34771414000; 7004933619; 26428191900; 59307439800; 7402784198 | ykkang@amc.seoul.kr; | GASTRIC CANCER | GASTRIC CANCER | 1436-3291 | 1436-3305 | 25 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;ONCOLOGY | 2022 | 7.4 | 17.6 | 1.41 | 2025-06-25 | 15 | 14 | Gastric cancer; Neoadjuvant chemotherapy; Lymph node staging; Radiological criteria | MULTIDETECTOR ROW CT; ADJUVANT CAPECITABINE; OPEN-LABEL; PHASE-3; GASTROGRAPHY; OXALIPLATIN; SURGERY; MDCT; S-1 | Gastric cancer; Lymph node staging; Neoadjuvant chemotherapy; Radiological criteria | Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Humans; Lymph Nodes; Neoadjuvant Therapy; Neoplasm Staging; Stomach Neoplasms; docetaxel; gimeracil plus oteracil potassium plus tegafur; oxaliplatin; antineoplastic agent; adjuvant therapy; adult; aged; Article; cancer staging; computer assisted tomography; diagnostic test accuracy study; female; histopathology; human; lymph node size; major clinical study; male; multiple cycle treatment; neoadjuvant chemotherapy; patient selection; predictive value; progression free survival; radiological parameters; risk reduction; sensitivity and specificity; stomach cancer; adjuvant chemotherapy; adverse event; diagnostic imaging; lymph node; neoadjuvant therapy; pathology; stomach tumor | English | 2022 | 2022-01 | 10.1007/s10120-021-01243-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Ramucirumab plus paclitaxel as a second-line treatment in HER2-positive gastric cancer: subgroup analysis of a nationwide, real-world study in Korea (KCSG-ST19-16) | Background A subgroup analysis of data from a nationwide study (KCSG-ST19-16) was performed to evaluate the efficacy and safety of second-line ramucirumab plus paclitaxel treatment in patients with human epidermal growth factor receptor 2 (HER2)-positive advanced gastric or gastro-esophageal junction (GEJ) adenocarcinoma. Methods The KCSG-ST19-16 study enrolled a total of 1063 patients from 56 hospitals in South Korea with advanced gastric or GEJ adenocarcinoma, who had received second-line treatment with ramucirumab plus paclitaxel. HER2 status was known for 994 (93.5%) of these patients, who were thus included in the subgroup analysis. Results In total, 163 of 994 patients (16.4%), had HER2-positive gastric or GEJ adenocarcinoma. The objective response rate to ramucirumab plus paclitaxel treatment was significantly higher in patients with HER2-positive disease compared to those with HER2-negative disease (23.0% [95% confidence interval (CI), 15.9-30.1] vs. 15.1% [95% CI, 12.3-17.9], p = 0.025). The median progression-free survival was longer in patients with HER2-positive versus HER2-negative disease, but the difference was not statistically significant (4.3 months [95% CI, 3.7-5.3] vs 3.7 months [95% CI, 3.4-4.0], p = 0.054). There was no statistically significant difference in median overall survival (OS) between the groups (9.8 months [95% CI, 8.9-12.3] vs 10.1 months [95% CI, 9.2-10.9], p = 0.564). Conclusions In patients with HER2-positive gastric or GEJ adenocarcinoma, the objective response rate to second-line treatment with ramucirumab plus paclitaxel was significantly higher compared to patients with HER2-negative disease. However, an increased response to treatment was not associated with an improvement in OS. | Kim, Bum Jun; Jee, Hee-Jung; Rha, Sun Young; Han, Hye Sook; Ryu, Min-Hee; Park, Se Hoon; Kim, Jong Gwang; Bae, Woo Kyun; Lee, Keun-Wook; Oh, Do-Youn; Byun, Ji-Hye; Kim, Dong Sook; Suh, Young Ju; An, Hyonggin; Zang, Dae Young | Hallym Univ, Med Ctr, Coll Med, Dept Internal Med,Div Hematol Oncol, Anyang Si 14068, Gyeonggi Do, South Korea; Chungnam Natl Univ, Sejong Hosp, Dept Biostat, Sejong, South Korea; Yonsei Univ, Coll Med, Songdang Inst Canc Res, Seoul, South Korea; Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Dept Med, Div Hematol Oncol, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Oncol Hematol, Daegu, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Internal Med, Hwasun, South Korea; Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Internal Med, 82 Gumi Ro 173 Beon Gil, Seongnam 13620, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Canc Res Inst, Coll Med, Seoul, South Korea; Hlth Insurance Review & Assessment Serv, Innovat Res Dept, Wonju, South Korea; Hlth Insurance Review & Assessment Serv, Review & Assessment Res Dept, Wonju, South Korea; Inha Univ, Coll Med, Dept Biomed Sci, Incheon, South Korea; Korea Univ, Coll Med, Dept Biostat, Seoul, South Korea; Yonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Internal Med,Div Med Oncol, Seoul, South Korea; Yonsei Univ, Coll Med, Brain Korea 21 PLUS Project Med Sci, Seoul, South Korea | Jee, Hee-Jung/AAY-9026-2020; Kim, Sung-Bae/JXL-8219-2024; Park, Se Hoon/GMX-1199-2022; Suh, Young/AAD-5737-2021 | 57191250433; 57191924509; 7006023235; 7401969147; 7101754860; 25960261300; 59501049300; 14028001300; 35205887300; 8836932000; 57262267000; 56109775000; 35752438900; 7202277445; 57216641597 | fhdzang@hallym.or.kr; | GASTRIC CANCER | GASTRIC CANCER | 1436-3291 | 1436-3305 | 25 | 3 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;ONCOLOGY | 2022 | 7.4 | 17.6 | 0.6 | 2025-06-25 | 6 | 6 | Stomach neoplasms; Ramucirumab; Paclitaxel; ErbB-2 | ENDOTHELIAL GROWTH-FACTOR; HER2; ADENOCARCINOMA; ANGIOGENESIS | ErbB-2; Paclitaxel; Ramucirumab; Stomach neoplasms | Adenocarcinoma; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Esophageal Neoplasms; Esophagogastric Junction; Humans; Paclitaxel; Republic of Korea; Stomach Neoplasms; antineoplastic agent; antineoplastic metal complex; capecitabine; cisplatin; epidermal growth factor receptor 2; fluoropyrimidine; fluorouracil; paclitaxel; programmed death 1 receptor antibody; ramucirumab; receptor antibody; trastuzumab; unclassified drug; antineoplastic agent; monoclonal antibody; paclitaxel; ramucirumab; adult; advanced cancer; aged; anemia; anorexia; Article; blood toxicity; cancer combination chemotherapy; cancer patient; cancer survival; controlled study; diarrhea; digestive system perforation; esophageal adenocarcinoma; fatigue; febrile neutropenia; female; gastroesophageal junction; gastrointestinal hemorrhage; human; human epidermal growth factor receptor 2 positive gastric cancer; human epidermal growth factor receptor 2 positive gastric cancer; human tissue; hypertension; infection; major clinical study; male; nausea; neutropenia; overall survival; progression free survival; proteinuria; retrospective study; South Korea; stomach adenocarcinoma; stomach cancer; stomatitis; survival rate; survival time; thrombocytopenia; thromboembolism; treatment response; vomiting; wound complication; adenocarcinoma; esophagus tumor; pathology; stomach tumor | English | 2022 | 2022-05 | 10.1007/s10120-021-01276-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Remission of type 2 diabetes after gastrectomy for gastric cancer: diabetes prediction score | Background Although type 2 diabetes (T2D) remission after gastric cancer surgery has been reported, little is known about the predictors of postoperative T2D remission. Methods This study used data from a nationwide cohort provided by the National Health Insurance Service in Korea. We developed a diabetes prediction (DP) score, which predicted postoperative T2D remissions using a logistic regression model based on preoperative variables. We applied machine-learning algorithms [random forest, XGboost, and least absolute shrinkage and selection operator (LASSO) regression] and compared their predictive performances with those of the DP score. Results The DP score comprised five parameters: baseline body mass index (= 25 kg/m(2)), surgical procedures (subtotal or total gastrectomy), age (= 65 years), fasting plasma glucose levels ( 130 mg/dL), and antidiabetic medications (combination therapy including sulfonylureas, combination therapy not including sulfonylureas, single sulfonylurea, or single non-sulfonylurea]). The DP score showed a clinically useful predictive performance for T2D remission at 3 years after surgery [training cohort: area under the receiver operating characteristics (AUROC) 0.73, 95% confidence interval (CI), 0.71-0.75; validation cohort: AUROC 0.72, 95% CI 0.69-0.75], which was comparable to that of the machine-learning models (random forest: AUROC 0.71, 95% CI 0.68-0.74; XGboost: AUROC 0.70, 95% CI 0.67-0.73; LASSO regression: AUROC 0.75, 95% CI 0.73-0.78 in the validation cohort). It also predicted the T2D remission at 6 and 9 years after surgery. Conclusions The DP score is a useful scoring system for predicting T2D remission after gastric cancer surgery. | Kwon, Yeongkeun; Kwon, Jin-Won; Ha, Jane; Kim, Dohyang; Cho, Jaehyeong; Jeon, Soo Min; Park, Shin-Hoo; Hwang, Jinseub; Kim, Nam Hoon; Park, Sungsoo | Korea Univ, Div Foregut Surg, Coll Med, Seoul, South Korea; Korea Univ, Ctr Obes & Metab Dis, Anam Hosp, Seoul, South Korea; Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Korea Univ, Dept Med, Coll Med, Seoul, South Korea; Daegu Univ, Dept Stat, Gyeongbuk, South Korea; Ajou Univ, Dept Biomed Sci, Grad Sch Med, Suwon, South Korea; Korea Univ, Div Endocrinol & Metab, Dept Internal Med, Coll Med, Seoul, South Korea | Park, Sun-Young/B-4634-2014; Kim, Nam Hoon/HNS-5794-2023 | 55970203000; 16202951700; 57217000677; 57218821860; 57200256446; 57206855645; 57188744111; 57189231296; 56984891100; 57187346700 | kugspss@korea.ac.kr; | GASTRIC CANCER | GASTRIC CANCER | 1436-3291 | 1436-3305 | 25 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;ONCOLOGY | 2022 | 7.4 | 17.6 | 0.5 | 2025-06-25 | 8 | 5 | Gastrectomy; Gastric cancer; Type 2 diabetes; Prediction | BETA-CELL FUNCTION; SUBTOTAL GASTRECTOMY; MORTALITY; MELLITUS; FOREGUT; GLUCOSE; SULFONYLUREA; COMORBIDITY; IMPROVEMENT; POPULATION | Gastrectomy; Gastric cancer; Prediction; Type 2 diabetes | Aged; Diabetes Mellitus, Type 2; Gastrectomy; Humans; Retrospective Studies; Stomach Neoplasms; Treatment Outcome; alpha glucosidase inhibitor; capecitabine; cisplatin; dipeptidyl peptidase IV inhibitor; docetaxel; doxorubicin; epirubicin; etoposide; fluorouracil; glitazone derivative; glucose; insulin; irinotecan; meglitinide; metformin; methotrexate; mitomycin; oxaliplatin; paclitaxel; sulfonylurea; tegafur; trastuzumab; adjuvant therapy; adult; age distribution; aged; area under the curve; Article; body mass; cohort analysis; diabetes prediction score; diagnostic test accuracy study; female; gastrectomy; glucose blood level; human; least absolute shrinkage and selection operator; machine learning; major clinical study; male; non insulin dependent diabetes mellitus; partial gastrectomy; prediction; random forest; receiver operating characteristic; remission; risk assessment; sensitivity and specificity; stomach cancer; total gastrectomy; gastrectomy; non insulin dependent diabetes mellitus; procedures; retrospective study; stomach tumor; treatment outcome | English | 2022 | 2022-01 | 10.1007/s10120-021-01216-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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