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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Radioluminescence characteristics of Eu2O3 ions activated CaO/CaF2+La2O3+P2O5 scintillating glasses | The novelty of this research is to prepare phosphate glasses (10CaO/CaF2 + 20La(2)O(3) + 69P(2)O(5)) with the effect of 1 mol% Eu2O3 and the incorporation of 10 mol% CaO (or) CaF2, focusing attention on their structural and optical features, together with their influence in the ultimate scintillation spectral response. When CaO (oxide, OE glass) content is replaced by CaF2 (fluoride, FE glass), changes in density and molar volume measurements are observed, including a decrease in the bands of O-H groups in the IR spectral range (2500-4000 cm(-1)). The results of the optical absorption (OA) of glasses showed various peaks in the ranges of 350-600 nm (UV-Visible) and 1800-2400 nm (NIR). The phonon energies of the OE (1219 cm(-1)) and FE (1210 cm(-1)) glasses from the Raman spectra are in good agreement with the value (1222 cm(-1)) obtained from the excitation (PLE) spectra (F-7(0) -> D-5(2)) of Eu3+ ions. From the emission (PL) spectra of glasses, the surrounding environment of Eu3+ ions is evaluated with respect to (omega 2,4,6) intensity parameters and asymmetric (R/O) ratio. Moreover, the OE and FE glasses emit the highest red-emitting D-5(0) -> F-7(2) transition (similar to 612 nm) under UV light and X-ray radiations. The decay time due to Eu3+ emission is 2.217 ms for OE glass and 2.329 ms for FE glass. In addition, spectroscopic parameters and (x, y) color coordinates are calculated for both glasses fabricated in this work. Furthermore, temperature-dependent luminescence was studied from 10 K to 550 K and found to high in FE glass. The inte-grated scintillation efficiencies of OE and FE glasses are about 17 % and 18 % of commercial BGO scintillating crystal. | Meejitpaisan, P.; Doddoji, Ramachari; Luewarasirikul, N.; Kim, H. J.; Kothan, S.; Kaewkhao, J. | Nakhon Pathom Rajabhat Univ, Fac Sci & Technol, Phys Program, Nakhon Pathom 73000, Thailand; Nakhon Pathom Rajabhat Univ, Ctr Excellence Glass Technol & Mat Sci CEGM, Nakhon Pathom 73000, Thailand; Duy Tan Univ, Inst Res & Dev, Da Nang 550000, Vietnam; Duy Tan Univ, Fac Nat Sci, Da Nang 550000, Vietnam; Suan Sunandha Rajabhat Univ, Fac Sci & Technol, Appl Phys Program, Bangkok 10300, Thailand; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Chiang Mai Univ, Fac Associated Med Sci, Ctr Radiat Res & Med Imaging, Dept Radiol Technol, Chiang Mai 50200, Thailand | ; Meejitpaisan, Piyachat/HSG-3266-2023; Ramachari, D./C-1205-2019 | 56006076500; 57214510277; 55871345500; 59051568100; 6507017165; 23974520300 | doddojiramachari@duytan.edu.vn;jakrapong@webmail.npru.ac.th; | INORGANIC CHEMISTRY COMMUNICATIONS | INORG CHEM COMMUN | 1387-7003 | 1879-0259 | 150 | SCIE | CHEMISTRY, INORGANIC & NUCLEAR | 2023 | 4.4 | 12.5 | 1.94 | 2025-06-25 | 11 | 13 | Eu3+-doped phosphate glasses; FTIR; JO and PSB analysis; X-ray and temperature dependent; luminescence; Spectroscopic-Scintillation characteristics | SPECTROSCOPIC PROPERTIES; EU3+ IONS; PHOSPHATE-GLASSES; LUMINESCENCE CHARACTERISTICS; TELLUROBORATE GLASSES; OXYFLUORIDE GLASSES; ENERGY-TRANSFER; RED EMISSION; LASER; BORATE | Eu<sup>3+</sup> -doped phosphate glasses; FTIR; JO and PSB analysis; Spectroscopic-Scintillation characteristics; X-ray and temperature dependent luminescence | English | 2023 | 2023-04 | 10.1016/j.inoche.2023.110488 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Spectral analysis of a parsec-scale jet in M 87: Observational constraint on the magnetic field strengths in the jet | Context. Because of its proximity and the large size of its black hole, M 87 is one of the best targets for studying the launching mechanism of active galactic nucleus jets. Currently, magnetic fields are considered to be an essential factor in the launching and accelerating of the jet. However, current observational estimates of the magnetic field strength of the M 87 jet are limited to the innermost part of the jet (less than or similar to 100 r(s)) or to HST-1 (similar to 10(5) r(s)). No attempt has yet been made to measure the magnetic field strength in between. Aims. We aim to infer the magnetic field strength of the M 87 jet out to a distance of several thousand r(s) by tracking the distance-dependent changes in the synchrotron spectrum of the jet from high-resolution very long baseline interferometry observations. Methods. In order to obtain high-quality spectral index maps, quasi-simultaneous observations at 22 and 43 GHz were conducted using the KVN and VERA Array (KaVA) and the Very Long Baseline Array (VLBA). We compared the spectral index distributions obtained from the observations with a model and placed limits on the magnetic field strengths as a function of distance. Results. The overall spectral morphology is broadly consistent over the course of these observations. The observed synchrotron spectrum rapidly steepens from alpha(22 - 43 GHz) similar to -0.7 at similar to 2 mas to alpha(22 - 43 GHz) similar to -2.5 at similar to 6 mas. In the KaVA observations, the spectral index remains unchanged until similar to 10 mas, but this trend is unclear in the VLBA observations. A spectral index model in which nonthermal electron injections inside the jet decrease with distance can adequately reproduce the observed trend. This suggests the magnetic field strength of the jet at a distance of 2-10 mas (similar to 900 r(s) - similar to 4500 r(s) in the deprojected distance) has a range of B = (0.3-1.0 G)(z/2mas)(-0.73). Extrapolating to the Event Horizon Telescope scale yields consistent results, suggesting that the majority of the magnetic flux of the jet near the black hole is preserved out to similar to 4500 r(s) without significant dissipation. | Ro, Hyunwook; Kino, Motoki; Sohn, Bong Won; Hada, Kazuhiro; Park, Jongho; Nakamura, Masanori; Cui, Yuzhu; Yi, Kunwoo; Chung, Aeree; Hodgson, Jeffrey; Kawashima, Tomohisa; An, Tao; Trippe, Sascha; Algaba, Juan-Carlos; Kim, Jae-Young; Sawada-Satoh, Satoko; Wajima, Kiyoaki; Shen, Zhiqiang; Cheng, Xiaopeng; Cho, Ilje; Jiang, Wu; Jung, Taehyun; Lee, Jee-Won; Niinuma, Kotaro; Oh, Junghwan; Tazaki, Fumie; Zhao, Guang-Yao; Akiyama, Kazunori; Honma, Mareki; Lee, Jeong Ae; Lu, Rusen; Zhang, Yingkang; Asada, Keiichi; Cui, Lang; Hagiwara, Yoshiaki; Hirota, Tomoya; Kawaguchi, Noriyuki; Koyama, Shoko; Lee, Sang-Sung; Oh, Se-Jin; Sugiyama, Koichiro; Takamura, Mieko; Wang, Xuezheng; Hwang, Ju-Yeon; Jung, Dong-Kyu; Kim, Hyo-Ryoung; Kim, Jeong-Sook; Kobayashi, Hideyuki; Oh, Chung-Sik; Oyama, Tomoaki; Roh, Duk-Gyoo; Yeom, Jae-Hwan | Yonsei Univ, Dept Astron, Yonsei Ro 50, Seoul 03722, South Korea; Korea Astron & Space Sci Inst, Daedeokdae Ro 776, Daejeon 34055, South Korea; Natl Astron Observ Japan, 2-21-1 Osawa, Mitaka, Tokyo 1818588, Japan; Kogakuin Univ Technol & Engn, Acad Support Ctr, 2665-1 Nakano, Hachioji, Tokyo 1920015, Japan; Univ Sci & Technol, Gajeong Ro 217, Daejeon 34113, South Korea; Natl Astron Observ Japan, Mizusawa VLBI Observ, 2-12 Hoshigaoka, Oshu, Iwate 0230861, Japan; Grad Univ Adv Studies SOKENDAI, Dept Astron Sci, 2-21-1 Osawa, Mitaka, Tokyo 1818588, Japan; Acad Sinica, Inst Astron & Astrophys, 11F Astron Math Bldg,AS-NTU 1,Sect 4 Roosevelt Rd, Taipei 10617, Taiwan; Seoul Natl Univ, Dept Phys & Astron, 1 Gwanak Ro, Seoul 08826, South Korea; Natl Inst Technol, Hachinohe Coll, Dept Gen Sci & Educ, 16-1 Tamonoki, Hachinohe, Aomori 0391192, Japan; Zhejiang Lab, Res Ctr Intelligent Comp Platforms, Hangzhou 311100, Peoples R China; Shanghai Jiao Tong Univ, Tsung Dao Lee Inst, Shanghai 201210, Peoples R China; Sejong Univ, Dept Phys & Astron, 209 Neungdong Ro, Seoul 05006, South Korea; Univ Tokyo, Inst Cosm Ray Res, 5-1-5 Kashiwanoha, Kashiwa, Chiba 2778582, Japan; Chinese Acad Sci, Shanghai Astron Observ, 80 Nandan Rd, Shanghai 200030, Peoples R China; Seoul Natl Univ, SNU Astron Res Ctr SNUARC, 1 Gwanak Ro, Seoul 08826, South Korea; Univ Malaya, Fac Sci, Dept Phys, Kuala Lumpur 50603, Malaysia; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 702701, South Korea; Max Planck Inst Radioastron, Hugel 69, D-53121 Bonn, Germany; Osaka Metropolitan Univ, Grad Sch Sci, Osaka 5998531, Japan; Yamaguchi Univ, Res Inst Time Studies, Yoshida 1677-1, Yamaguchi, Yamaguchi 7538511, Japan; Chinese Acad Sci, Key Lab Radio Astron, Nanjing 210008, Peoples R China; CSIC, Inst Astrofis Andalucia, Glorieta Astron S-N, Granada 18008, Spain; Yamaguchi Univ, Grad Sch Sci & Technol Innovat, 1677-1 Yoshida, Yamaguchi, Yamaguchi 7538511, Japan; Joint Inst VLBI ERIC, NL-7991 PD Dwingeloo, Netherlands; Tokyo Electron Technol Solut Ltd, Iwate 0231101, Japan; MIT, Haystack Observ, 99 Millstone Rd, Westford, MA 01886 USA; Harvard Univ, Black Hole Initiat, 20 Garden St, Cambridge, MA 02138 USA; Chinese Acad Sci, Xinjiang Astron Observ, Urumqi 830011, Peoples R China; Toyo Univ, 5-28-20 Hakusan,Bunkyo Ku, Tokyo 1128606, Japan; Niigata Univ, 8050 Ikarashi 2 No Cho,Nishi Ku, Niigata 9502181, Japan; Natl Astron Res Inst Thailand, Publ Org, 260 Moo 4 T Donkaew A Maerim, Chiangmai 50180, Thailand; Univ Tokyo, Dept Astron, 7-3-1 Hongo, Tokyo 1130033, Japan; UNIST, Dept Phys, Ulsan 44919, South Korea; Chungbuk Natl Univ, Basic Sci Res Inst, Chungdae Ro 1, Cheongju 28644, South Korea | Kim, Jae-Young/IUO-6466-2023; Cheng, Xiaopeng/ABX-5356-2022; Algaba, Juan Carlos/AAB-4526-2022; Hideyuki, Kobayashi/JCO-5851-2023; Cho, Ilje/LSL-5339-2024; Kino, Motoki/LQK-9129-2024; 浅田圭一, Keiichi/ABC-2456-2020; Kawashima, Tomohisa/GYD-8953-2022; Zhao, Guang-Yao/AAA-7324-2019; Cui, Yuzhu/MBG-4427-2025; Wajima, Kiyoaki/ABA-6807-2020; Zhang, Yingkang/GSN-8671-2022; Matsushita, Satoki/ABD-5562-2020; Lee, Sang-Sung/AFS-2722-2022; Park, Jongho/JFB-2747-2023; Lee, Jeong/G-7361-2012 | 57132341400; 57200125402; 25628978700; 45361061000; 56953647500; 57223767933; 57208319438; 57224005102; 8100674200; 55622269600; 35077169800; 35621621600; 8559107900; 25640916000; 57211836467; 6603503908; 6701802709; 7403324447; 57194012321; 57203071154; 57198407425; 38061540500; 55870740000; 12797989300; 56318374100; 43361892500; 55478882500; 55669706400; 57212328699; 36782468900; 55328189400; 56653547400; 7102181737; 23024178000; 55136627700; 35786028200; 7102913956; 55441260500; 37056945900; 55946836600; 23486850100; 57382524300; 57224014880; 57191585291; 16151089200; 7410137012; 57387021900; 55683255300; 57207278661; 7202790050; 7005887109; 54880029700 | hwro@yonsei.ac.kr; | ASTRONOMY & ASTROPHYSICS | ASTRON ASTROPHYS | 0004-6361 | 1432-0746 | 673 | SCIE | ASTRONOMY & ASTROPHYSICS | 2023 | 5.4 | 12.5 | 1.31 | 2025-06-25 | 10 | 11 | galaxies: active; galaxies: individual: M 87; galaxies: jets; radio continuum: galaxies; relativistic processes; techniques: interferometric | ACTIVE GALACTIC NUCLEI; BLACK-HOLE MASS; GAMMA-RAY FLARE; M87 JET; VLBI OBSERVATIONS; SCHWARZSCHILD RADII; CORE-SHIFT; RELATIVISTIC JETS; DYNAMICAL MODELS; FREQUENCY VLBI | Galaxies: active; Galaxies: individual: M 87; Galaxies: jets; Radio continuum: galaxies; Relativistic processes; Techniques: interferometric | Galaxies; Gravitation; Magnetic fields; Maps; Radio astronomy; Spectrum analysis; Stars; Galaxies active; Galaxies jets; Galaxies: individuals; Galaxy: individual: M 87; Magnetic field strengths; Radio continuum: galaxies; Relativistic process; Relativistics; Spectral indices; Technique: interferometric; Interferometry | English | 2023 | 2023-05-24 | 10.1051/0004-6361/202142988 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The detection of substellar companions around HD 6860 and HD 112300 | Context. Certain periodic variations of radial velocities (RVs) of wobbling giants originate from exoplanets. A number of exoplanets have been discovered around giant stars.Aims. The purpose of our study is to find low-amplitude and long-period RV variations around bright M (super) giants in the red giant branch (or asymptotic giant branch) stage, which are long-period variables (LPVs) or high proper motion stars.Methods. The high-resolution fiber-fed Bohyunsan Observatory Echelle Spectrograph (BOES) at the Bohyunsan Optical Astronomy Observatory (BOAO) was used to record numerous spectra of nine giants. The observation period for the targets spanned 16 yr, from 2005 to 2022.Results. We found two substellar companions from the precise RV observations of nine M giants. One companion has a 28.26-2.17+2.05 MJ orbiting period of 663.87-4.31+4.61 days at a distance of 2.03-0.01+0.01 AU (HD 6860), and the other has a 15.83-2.74+2.33 MJ orbiting period of 466.63-1.28+1.47 days at a distance of 1.33-0.11+0.08 AU (HD 112300). Our estimate of the stellar parameters for HD 6860 makes it the currently largest star with a substellar companion. We also found RV variations mimicking a planetary companion in HD 18884 and confirmed LPVs in two stars, HD 39801 and HD 42995. The RV variations of some stars seem to be associated with stellar activities rather than reflex orbital motion due to their companions. Variations like this are also detected for HD 6860 and HD 112300, which host substellar companions. | Lee, Byeong-Cheol; Do, Hee-Jin; Park, Myeong-Gu; Lim, Beomdu; Choi, Yeon-Ho; Koo, Jae-Rim; Bang, Tae-Yang; Oh, Hyeong-Ill; Han, Inwoo; Chang, Heon-Young | Korea Astron & Space Sci Inst, 776 Daedeokdae Ro, Daejeon 305348, South Korea; Seoul Natl Univ Sci & Technol, Dept Mech & Automot Engn, Daejeon 34113, South Korea; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 41566, South Korea; Kongju Natl Univ, Dept Hlth Adm, 56 Gongjudaehak Ro, Gongju Si 32588, Chungcheongnam, South Korea | 8878262900; 58542661500; 7404490321; 36499772800; 57247914500; 15127066700; 57201317966; 59098226900; 7201559866; 7407524806 | bclee@kasi.re.kr;taekwon@nate.com; | ASTRONOMY & ASTROPHYSICS | ASTRON ASTROPHYS | 0004-6361 | 1432-0746 | 678 | SCIE | ASTRONOMY & ASTROPHYSICS | 2023 | 5.4 | 12.5 | 0.24 | 2025-06-25 | 3 | 2 | techniques: radial velocities; stars: individual: HD 6860; stars: late-type; stars: individual: HD 112300 | RADIAL-VELOCITY VARIATIONS; GIANT PLANET; STARS; BETELGEUSE; PHOTOMETRY; CATALOG; SEARCH; MASS; VARIABILITY; PARAMETERS | Stars: individual: HD 112300; Stars: individual: HD 6860; Stars: late-type; Techniques: radial velocities | Extrasolar planets; Giant stars; Orbits; Exo-planets; Long period variables; Radial velocity; Star: individual: HD 112300; Star: individual: HD 6860; Stars: individual: proxima Centauri; Stars:late type; Techniques: radial velocities; Velocity variations; Observatories | English | 2023 | 2023-10-13 | 10.1051/0004-6361/202243725 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | "Click-to-Clear": A Strategy to Minimize Radioactivity from the Blood Pool Utilizing Staudinger Ligation | The availability of several bioorthogonal reactions that can proceed selectively and efficiently under physiologically relevant conditions has garnered the interest of biochemists and organic chemists alike. Bioorthogonal cleavage reactions represent the latest innovation in click chemistry. Here, we employed the Staudinger ligation reaction to release radioactivity from immunoconjugates, improving target-to-background ratios. In this proof-of-concept study, model systems, including the anti-HER2 antibody trastuzumab, radioisotope I-131, and a newly synthesized bifunctional phosphine, were used. Staudinger ligation occurred when biocompatible N-glycosyl azides reacted with this radiolabeled immunoconjugate, leading to cleavage of the radioactive label from the molecule. We demonstrated this click cleavage in vitro and in vivo. Biodistribution studies in tumor models showed that radioactivity was eliminated from the bloodstream, thereby improving tumor-to-blood ratios. SPECT imaging revealed that tumors could be visualized with enhanced clarity. Our simple approach represents a novel application of bioorthogonal click chemistry in the development of antibody-based theranostics. | Soni, Nisarg; Sarkar, Swarbhanu; Bhise, Abhinav; Ha, Yeong Su; Park, Wonchoul; Yu, A-Ram; Kumar, Virendra; Lim, Jeong Eun; Yoon, Young-Ran; Yoo, Jeongsoo | Kyungpook Natl Univ, Sch Med, Dept Mol Med, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea; BIOMAX Ltd, 232,Gongneung Ro, Seoul 01811, South Korea; OSONG Med Innovat Fdn, Nonclin Ctr, Cheongju 28160, South Korea | Sarkar, Swarbhanu/ISS-1138-2023; Bhise, Abhinav/MVY-6473-2025; Yoon, Young-Ran/GLT-0172-2022; Kumar, Dr. Virendra/KCZ-3518-2024 | 56364076200; 36603493100; 57210174595; 36720940600; 58166254100; 58165826300; 57688170500; 57732661800; 14629744500; 8215136400 | yooj@knu.ac.kr; | PHARMACEUTICS | PHARMACEUTICS | 1999-4923 | 15 | 3 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 4.9 | 12.9 | 0.8 | 2025-06-25 | 5 | 5 | Staudinger ligation; click chemistry; clearing agent; tumor imaging | MONOCLONAL-ANTIBODIES; CHEMISTRY; THERAPY; RELEASE | clearing agent; click chemistry; Staudinger ligation; tumor imaging | acetonitrile; antibody drug conjugate; azide; chemical compound; diphenyl phosphine terephthalate analog; epidermal growth factor receptor 2; iodine 131; phosphine; radioisotope; tetrahydrofuran; trastuzumab; unclassified drug; zidovudine; 3T6-Swiss albino cell line; animal experiment; animal model; Article; blood; cell viability; chemical reaction; click chemistry; column chromatography; controlled study; cytotoxicity; drug synthesis; electrospray; female; HEK293 cell line; high performance liquid chromatography; human; human cell; in vitro study; in vivo study; male; mass spectrometry; mouse; nonhuman; nuclear magnetic resonance; proof of concept; proton nuclear magnetic resonance; radioactivity; radiolabeling; single photon emission computed tomography; Staudinger Ligation; tumor-to-blood ratio | English | 2023 | 2023-03 | 10.3390/pharmaceutics15030719 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Age is a determinant factor in the susceptibility of domestic ducks to H5 clade 2.3.2.1c and 2.3.4.4e high pathogenicity avian influenza viruses | High pathogenicity avian influenza (HPAI) is a viral disease with devastating consequences for the poultry industry worldwide. Domestic ducks are a major source of HPAI viruses in many Eurasian countries. The infectivity and pathogenicity of HPAI viruses in ducks vary depending on host and viral factors. To assess the factors influencing the infectivity and pathogenicity of HPAI viruses in ducks, we compared the pathobiology of two HPAI viruses (H5N1 clade 2.3.2.1c and H5N6 clade 2.3.4.4e) in 5- and 25-week-old ducks. Both HPAI viruses caused mortality in a dose-dependent manner (10(4), 10(6), and 10(8) EID50) in young ducks. By contrast, adult ducks were infected but exhibited no mortality due to either virus. Viral excretion was higher in young ducks than in adults, regardless of the HPAI strain. These findings demonstrate the age-dependent mortality of clade 2.3.2.1c and clade 2.3.4.4e H5 HPAI viruses in ducks. | Lee, Sun-Hak; Lee, Jiho; Noh, Jin-Yong; Jeong, Jei-Hyun; Kim, Jun-Beom; Kwon, Jung-Hoon; Youk, Sungsu; Song, Chang-Seon; Lee, Dong-Hun | Konkuk Univ, Coll Vet Med, Avian Dis Lab, Seoul, South Korea; KHAV Co Ltd, Seoul, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Microbiol, Daegu, South Korea; Chungbuk Natl Univ, Coll Med, Dept Microbiol, Cheongju, South Korea; Konkuk Univ, Coll Vet Med, Wildlife Hlth Lab, Seoul, South Korea | Youk, Sungsu/AAC-2316-2019; Kim, Sunghoon/Z-2981-2019; Song, Chang-Seon/D-7282-2011 | 57201463694; 57194496544; 55346236400; 57077501100; 57194501404; 55559800200; 54418384600; 55555239800; 57776535400 | donghunlee@konkuk.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 0.74 | 2025-06-25 | 2 | 2 | high pathogenicity avian influenza; clade 2; 3; 2; 4; age-related pathogenicity; duck | WILD BIRDS; HONG-KONG; INFECTION; PATHOGENESIS; PATHOBIOLOGY; OUTBREAKS; VIETNAM; SPREAD; GEESE | age-related pathogenicity; clade 2.3.2.1c H5N1; clade 2.3.4.4e H5N6; duck; high pathogenicity avian influenza | adult; age; Anas platyrhynchos; animal experiment; Article; cladistics; controlled study; duckling; highly pathogenic avian influenza; highly pathogenic avian influenza virus; Influenza A virus (H5N1); limit of detection; morbidity; mortality; nonhuman; pathogenicity; pathology; survival rate; time of death; virus shedding | English | 2023 | 2023-07-20 | 10.3389/fvets.2023.1207289 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Attending veterinarians improve the research capability and psychological well-being of researchers in animal research institutes | The use of laboratory animals in biomedical research has significantly advanced scientific understanding, yet it raises ethical concerns about animal welfare and the mental health of researchers Recent research has highlighted the potential for stress and compassion fatigue among researchers working with distressed animals. Attending veterinarians (AVs) are crucial in mitigating the pain and stress experienced by animals and, by extension, researchers. However, the impact of AVs on researchers’ psychological well-being remains understudied. This study explores how AVs contribute to researchers’ research capability and psychological well-being in animal research institutions. AVs oversee animal housing, health, and welfare; their involvement is mandated or strongly recommended in developed countries. AVs enhance animal welfare by ensuring proper housing, nutrition, and social interaction. They monitor animal health, educate researchers on pain assessment, and promote compliance with post-surgical care. AVs also contribute to researchers’ well-being by addressing euthanasia procedures, which can be emotionally challenging. Programs for rehoming animals after experiments offer an alternative to euthanasia and positively impact researchers’ psychological well-being. Moreover, AVs promote workplace well-being by fostering positive workplace cultures, offering peer counseling, and providing social support. Programs considering animal welfare and researchers’ emotions are crucial for a healthy research environment. In conclusion, AVs are essential in balancing scientific progress with animal welfare and researchers’ psychological well-being. Therefore, their role should be recognized as vital in achieving social equity that considers the welfare of humans and laboratory animals. Copyright © 2024 Lee, Lee and Kim. | Lee, Ji Min; Lee, Gwang-Hoon; Kim, KilSoo | Research Ethics Team, Seoul National University, Seoul, South Korea; Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea; Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea, Department of Veterinary Toxicology, College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea | 58821069700; 57266540000; 35272034300 | ghl@kmedihub.re.kr;kskim728@knu.ac.kr; | Frontiers in Veterinary Science | FRONT VET SCI | N/A | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 0.74 | 2025-06-25 | 2 | animal research; animal welfare; attending veterinarians; care-killing paradox; professional quality of life | animal health; animal housing; animal welfare; Article; compassion fatigue; emotion; emotional well-being; employment; euthanasia; experimental animal; human; medical research; mental health; nutrition; pain; pain assessment; peer counseling; physiological stress; postoperative care; psychological well-being; quality of life; responsibility; social equity; social interaction; social support; veterinarian; wellbeing; workplace | English | Final | 2023 | 10.3389/fvets.2023.1340225 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Case report: Fatal neonatal sepsis associated with Escherichia fergusonii infection in a common bottlenose dolphin (Tursiops truncatus) | A 25-day-old male common bottlenose dolphin (Tursiops truncatus) died suddenly while swimming at a dolphinarium. The gross examination revealed ulceration on the dorsal and pectoral fins and rostrum. Severe congestion, hemorrhage, and edema were observed in the gastrointestinal tract, liver, mesenteric lymph nodes, lungs, and kidneys. Fibrinosuppurative arthritis of the atlantooccipital joint and extension of fibrin into the spinal canal caused compression of the spinal cord. Histopathological examination revealed tracheitis, fibrinosuppurative bronchopneumonia and enteritis. In the central nervous system, meningeal vessel congestion in the brain, and intraparenchymal hemorrhages with neurodegeneration were observed in the spinal cord. Based on the histopathological findings, representative samples, including lung, liver, mesenteric lymph node, blood obtained from the jugular vein, and fluid sample of the ascites, were inoculated on tryptic soy agar and blood agar for routine bacterial isolation. Each isolated bacterial colony was streaked aseptically onto tryptic soy agar and blood agar for pure culture. After then, polymerase chain reaction (PCR) was performed for further identification of pathogenic microorganisms. PCR identified Escherichia fergusonii, Shewanella haliotis, Enterococcus faecalis, and Staphylococcus schleiferi. E. fergusonii was considered the primary etiologic agent in this case since it was the only species identified in all representative samples. The cause of death in this animal was E. fergusonii sepsis. To the best of our knowledge, this is the first case of neonatal sepsis associated with E. fergusonii infection in a dolphin, and suggests E. fergusonii as an opportunistic pathogen associated with sepsis in dolphins. | Baek, Su-Min; Lee, Seoung-Woo; Kim, Tae-Un; Kim, Ji Hyung; Lee, Young-Jin; Yim, Jae-Hyuk; Kim, Woo Jun; Choi, Seong-Kyoon; Han, Jee Eun; Jeong, Kyu-Shik; Park, Jin-Kyu | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Pathol, Daegu 41566, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu, South Korea; Daegu Gyeongbuk Inst Sci & Technol DGIST, Core Prot Resources Ctr, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol, Infect Dis Res Ctr, Daejeon 34141, South Korea; Gachon Univ, Dept Food Sci & Biotechnol, Seongnam, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea | Jeong, Kyu-Shik/D-6740-2011; Kim, Woo/D-2733-2015; Kim, Ji Hyung/B-7321-2011 | 57207938426; 57218827581; 57214091908; 57225000204; 57491815500; 57221330255; 58562430300; 55505432500; 57214671240; 7201556460; 35213723500 | jinkyu820@knu.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 0 | 2025-06-25 | 0 | 0 | sepsis; Escherichia fergusonii; dolphin; neonate; cetaceans | SEPTICEMIA | cetaceans; dolphin; Escherichia fergusonii; neonate; sepsis | fibrin; animal cell; animal experiment; animal model; animal tissue; arthritis; Article; ascites; atlantooccipital joint; autopsy; bacteremia; bacterial infection; bacterial strain; bacterium colony; bacterium culture; bacterium identification; bacterium isolation; bleeding; blood sampling; bronchopneumonia; cell destruction; cell infiltration; coinfection; disease association; dorsal fin; edema; enteritis; Enterobacteriaceae infection; Enterococcus faecalis infection; epithelium cell; Escherichia fergusonii; Escherichia fergusonii infection; fatality; gastrointestinal tract; Gram staining; histopathology; hyperemia; intestine cell; kidney; liver; lung; lymphocyte; macrophage; male; mesentery lymph node; microscopy; neutrophil; newborn sepsis; nonhuman; nucleotide sequence; pectoral fin; plasma cell; polymerase chain reaction; Shewanella haliotis infection; skin incision; snout; spinal cord atrophy; spinal cord compression; Staphylococcus infection; Staphylococcus schleiferi infection; sudden death; swimming; tracheitis; Tursiops truncatus; ulcer; vertebral canal | English | 2023 | 2023-09-26 | 10.3389/fvets.2023.1242599 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Chimeric H5 influenza virus-like particle vaccine elicits broader cross-clade antibody responses in chickens than in ducks | Eurasian-lineage highly pathogenic avian influenza (HPAI) H5 viruses have spread throughout Asia, the Middle East, Europe, Africa, and most recently, North and South America. These viruses are independently evolving into genetically and antigenically divergent clades, and broad-spectrum vaccines protecting against these divergent clades are needed. In this study, we developed a chimeric virus-like particle (VLP) vaccine co-expressing hemagglutinins from two clades (clades 1 and 2.3.2.1) of HPAI H5 viruses and performed comparative cross-clade hemagglutination inhibition (HI) analysis in chickens and ducks. The chimeric VLP immunization induced a significantly broader spectrum of antibodies against various clades of HPAI H5 viruses than monovalent VLPs both in chickens and ducks. While the chimeric VLP led to broadened antibody responses in both species, significantly lower levels of HI antibodies were elicited in ducks than in chickens. Moreover, boost immunization failed to increase antibody responses in ducks regardless of the VLPs used, in contrast to chickens that showed significantly enhanced antibody responses upon boost immunization. These results suggest (1) the potential application of the chimeric VLP technology in poultry to help control HPAI H5 viruses by offering broader antibody responses against antigenically different strains and (2) possible obstacles in generating high levels of antibody responses against HPAI H5 viruses in ducks via vaccination, implying the need for advanced vaccination strategies for ducks. | Park, Jaekeun; Song, Chang-Seon; Chung, David Hyunjung; Choi, Sangyong; Kwon, Junghoon; Youk, Sungsu; Lee, Dong-Hun | Konkuk Univ, Coll Vet Med, Seoul, South Korea; Univ Maryland, Virginia Maryland Coll Vet Med, Dept Vet Med, College Pk, MD USA; Univ Connecticut, Dept Pathobiol & Vet Sci, Storrs, CT USA; Univ Connecticut, Dept Nutr Sci, Storrs, CT USA; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Chungbuk Natl Univ, Coll Med, Cheongju, South Korea; Chungbuk Natl Univ, Med Res Inst, Cheongju, South Korea | Choi, Sangyong/MBH-2356-2025; Song, Chang-Seon/D-7282-2011; Youk, Sungsu/AAC-2316-2019 | 36953385300; 55555239800; 57220078849; 58481911100; 55559800200; 54418384600; 57776535400 | donghunlee@konkuk.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 0.37 | 2025-06-25 | 1 | 1 | highly pathogenic avian influenza virus; vaccine; virus like particle; insect cell; poultry; chicken; duck | PATHOGENIC AVIAN INFLUENZA; EFFICACY; PROTECTION; CHALLENGE; EVOLUTION; STRATEGY; POULTRY | chicken; duck; highly pathogenic avian influenza virus; insect cell; poultry; vaccine; virus like particle | avian influenza vaccine; chimeric h5 influenza virus like particle vaccine; hemagglutinin; unclassified drug; antibody blood level; antibody response; antibody titer; antigenicity; Article; avian influenza (H5N1); baculovirus expression system; cladistics; comparative study; drug development; Gallus gallus; hemagglutination inhibition test; highly pathogenic avian influenza virus; immune response; immunization; infection control; nonhuman; Pekin duck; poultry; protein expression; seroconversion; virus like agent; virus strain | English | 2023 | 2023-06-15 | 10.3389/fvets.2023.1158233 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Detection of intercontinental reassortant H6 avian influenza viruses from wild birds in South Korea, 2015 and 2017 | Avian influenza viruses (AIVs) in wild birds are phylogenetically separated in Eurasian and North American lineages due to the separated distribution and migration of wild birds. However, AIVs are occasionally dispersed between two continents by migratory wild birds flying across the Bering Strait. In this study, we isolated three AIVs from wild bird feces collected in South Korea that contain gene segments derived from American lineage AIVs, including an H6N2 isolated in 2015 and two H6N1 in 2017. Phylogenetic analysis suggests that the H6N2 virus had American lineage matrix gene and the H6N1 viruses had American lineage nucleoprotein and non-structural genes. These results highlight that novel AIVs have continuously emerged by reassortment between viruses from the two continents. Therefore, continuous monitoring for the emergence and intercontinental spread of novel reassortant AIV is required to prepare for a possible future outbreak. | Kim, Ji-Yun; Lee, Sun-Hak; Kim, Da-Won; Lee, Dong-Wook; Song, Chang-Seon; Lee, Dong-Hun; Kwon, Jung-Hoon | Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Konkuk Univ, Coll Vet Med, Avian Dis Lab, Seoul, South Korea; Konkuk Univ, Coll Vet Med, Wildlife Hlth Lab, Seoul, South Korea | ; Song, Chang-Seon/D-7282-2011 | 57299583700; 57201463694; 57299949900; 57711484300; 55555239800; 57776535400; 55559800200 | donghunlee@konkuk.ac.kr;Junghoon.kwon@knu.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 0 | 2025-06-25 | 0 | 0 | influenza virus; reassortment; phylogenetic analysis; wild bird; South Korea | COMPLETE GENOME SEQUENCE; NORTH-AMERICA; EXCHANGE; ALASKA; GENES; ASIA | influenza virus; phylogenetic analysis; reassortment; South Korea; wild bird | Anas platyrhynchos; antibody response; Article; avian influenza; avian influenza virus; feces; Gallus gallus; genetic reassortment; nonhuman; phylogeny; South Korea; virus shedding; whole genome sequencing | English | 2023 | 2023-06-12 | 10.3389/fvets.2023.1157984 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Domain adapted broiler density map estimation using negative-patch data augmentation | To overcome the lack of labelled data in real-world situations such as agriculture, transfer learning has recently been in the spotlight. Domain adaptation is a transfer learning method that can migrate well learned knowledge from a source domain to a target domain. However, it is difficult to ensure the generalisation to adequate feature space when source and target domain are heterogeneous due to their excessive domain shift. In this study, a negative-patch (NP) data augmentation was proposed to improve the domain adaptation performance between heterogeneous domains for density map estimation. The proposed NP was applied to Domain-Adversarial Training of Neural Networks (DANN) for broiler flock density estimation. A people crowd dataset and a broiler dataset were used as source and target domain datasets, respectively. Experiments were conducted by the model configuration, and the broiler counting performances were compared. The results showed that the DANN with NP could reduce the error by up to 54% for DANN without NP and that the NP has demonstrated its generalized performance for multiple source domain datasets. & COPY; 2023 IAgrE. Published by Elsevier Ltd. All rights reserved. | Kim, Taehyeong; Lee, Dae-Hyun; Kim, Wan-Soo; Zhang, Byoung-Tak | Seoul Natl Univ, Dept Biosyst Engn, Seoul 08826, South Korea; Seoul Natl Univ, Integrated Major Global Smart Farm, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 08826, South Korea; Chungnam Natl Univ, Dept Biosyst Machinery Engn, Daejeon 34134, South Korea; Kyungpook Natl Univ, Dept Bioind Machinery Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Upland Field Machinery Res Ctr, Daegu 41566, South Korea; Seoul Natl Univ, Artificial Intelligence Inst, Seoul 08826, South Korea | ; Lee, Dae/T-9838-2019 | 57205305072; 55541929900; 57192918810; 55765845700 | leedh7@cnu.ac.kr;btzhang@bi.snu.ac.kr; | BIOSYSTEMS ENGINEERING | BIOSYST ENG | 1537-5110 | 1537-5129 | 231 | SCIE | AGRICULTURAL ENGINEERING;AGRICULTURE, MULTIDISCIPLINARY | 2023 | 4.4 | 12.9 | 0.29 | 2025-06-25 | 2 | 2 | Negative patch; Domain adaptation; Density estimation; Broiler count; Deep neural networks | PERFORMANCE; BEHAVIOR; WELFARE | Broiler count; Deep neural networks; Density estimation; Domain adaptation; Negative patch | Learning systems; Transfer learning; Broiler count; Data augmentation; Density estimation; Density maps; Domain adaptation; MAP estimation; Negative patch; Neural-networks; Performance; Target domain; Deep neural networks | English | 2023 | 2023-07 | 10.1016/j.biosystemseng.2023.06.006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluation of progression of chronic kidney disease in dogs with myxomatous mitral valve disease | Introduction: Cardiovascular and renal diseases are known to affect each other in the cardiovascular renal axis disorder (CvRD). Although CvRD, which includes myxomatous mitral valve disease (MMVD) and chronic kidney disease (CKD), has been described in dogs, there are only a few reports on the progression of CKD in accordance with the severity of MMVD. The aim of this study was to evaluate whether the presence of MMVD is associated with the rate of progression of CKD in dogs. The time from the initial diagnosis to the worsening of the International Renal Interest Society (IRIS) stage and the time for the occurrence of hyperphosphatemia and isosthenuria were evaluated.Materials and methods: In this retrospective study, CKD progression was determined as an increase in the IRIS stage by at least one level and the development of hyperphosphatemia or isosthenuria. The CKD progression was compared in dogs with and without comorbid MMVD.Results: Dogs with CKD were divided into two groups: dogs with and without MMVD (n = 63, concurrent group; n = 52, CKD group, respectively). The concurrent group was further divided into two subgroups based on the American College of Veterinary Internal Medicine guidelines (B1 group, n = 24; B2 group, n = 39). The time for progression of CKD from IRIS stage 1 to IRIS stage 2 was significantly shorter in the concurrent group than in the CKD group (log-rank test, p < 0.001). MMVD was associated with an increased risk of progression from stage 1 to stage 2 (hazard ratio, 6.442; 95% confidence interval (CI), 2.354 to 18.850; p < 0.001). The timing of the onset of hyperphosphatemia or isosthenuria in the concurrent group and the CKD group was not significantly different.Conclusion: The results of this study suggest that MMVD could be a risk factor for the progression of CKD. Our findings may help predict the prognosis of dogs with both CKD and MMVD compared to CKD only. | Yun, Hyejin; Koo, Yoonhoi; Yun, Taesik; Chae, Yeon; Lee, Dohee; Cha, Sijin; Kim, Jeeyune; Kim, Hakhyun; Yang, Mhan Pyo; Kang, Byeong Teck | Chungbuk Natl Univ, Coll Vet Med, Lab Vet Internal Med, Cheongju, Chungbuk, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea | yun, hyejin/KQU-4403-2024 | 58061918700; 57220050745; 57209458067; 57215577118; 57226189094; 58564731200; 59089910500; 57192503045; 7404927049; 8858992400 | kangbt@chungbuk.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 0.37 | 2025-06-25 | 1 | 1 | cardiovascular-renal disease; chronic kidney disease; myxomatous mitral valve disease; heart; kidney | CARDIOVASCULAR-DISEASE; HEART; PATHOPHYSIOLOGY; NOREPINEPHRINE; REGURGITATION; ASSOCIATION; MODULATION; ACTIVATION; DISORDERS; SYSTEM | cardiovascular-renal disease; chronic kidney disease; heart; kidney; myxomatous mitral valve disease | pimobendan; American college of veterinary internal medicine; Article; case control study; chronic kidney failure; clinical evaluation; college; comparative study; controlled study; demographics; disease exacerbation; dog; female; hyperphosphatemia; international renal interest society; isosthenuria; kidney disease; male; medical society; mitral valve disease; myxomatous mitral valve disease; nonhuman; practice guideline; retrospective study | English | 2023 | 2023-08-24 | 10.3389/fvets.2023.1200653 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Expression of vitamin D receptor, CYP24A1, and CYP27B1 in normal and inflamed canine pancreases | Vitamin D plays a role in anti-inflammatory processes, and the alteration of its metabolism is associated with the inflammatory processes of pancreatitis. This study was performed to evaluate the expression of the vitamin D receptor (VDR) and the two major enzymes that regulate vitamin D metabolism, 1α-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1), in the canine pancreas and to compare their degrees of immunoreactivity between normal and inflamed pancreases. Five normal and inflamed pancreatic tissues each were obtained from six dogs. The expression of VDR, CYP24A1, and CYP27B1 were determined immunohistochemically, and the degree of immunostaining was assessed semiquantitatively. The VDR was expressed in the ducts, acini, and islets of Langerhans of normal pancreases and in the ducts and acini of inflamed ones. There was a significant difference in the immunoreactivity score for VDR in the islets of Langerhans between normal (median, 3 [interquartile range, 2–7.5] score) and inflamed pancreatic tissues (0 [0–0.5] score, p = 0.03). CYP24A1 was expressed in the ducts and islets of Langerhans in both normal and inflamed pancreases, whereas CYP27B1 was expressed in the ducts and acini in only some normal and inflamed pancreatic tissues. This study showed that VDR expression decreased in inflamed pancreases and demonstrated CYP24A1 and CYP27B1 expression in the canine pancreas for the first time. These findings indicate that the pancreas could regulate the metabolism and biological activity of vitamin D and suggest that a decrease in these might be related to the pathophysiology of pancreatitis. Copyright © 2023 Lee, Kim, Koo, Chae, Wang, Kim, Yun, Yang, Kang and Kim. | Lee, Dohee; Kim, Sanggu; Koo, Yoonhoi; Chae, Yeon; Wang, Juwon; Kim, Soochong; Yun, Taesik; Yang, Mhan-Pyo; Kang, Byeong-Teck; Kim, Hakhyun | Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea; Laboratory of Veterinary Pathology and Platelet Signaling, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea; Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea, College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea; Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea; Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea; Laboratory of Veterinary Pathology and Platelet Signaling, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea; Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea; Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea; Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea; Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea | 57226189094; 57220812847; 57220050745; 57215577118; 58642619500; 7601600702; 57209458067; 7404927049; 8858992400; 57192503045 | kimh@chungbuk.ac.kr; | Frontiers in Veterinary Science | FRONT VET SCI | N/A | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 0 | 2025-06-25 | 1 | CYP24A1; CYP27B1; dog; immunohistochemistry; pancreatic tissue; pancreatitis; vitamin D receptor | colecalciferol 24 hydroxylase; oxygenase; vitamin D receptor; animal cell; animal experiment; animal model; animal tissue; Article; controlled study; dog; female; immunocompetent cell; immunohistochemistry; immunoreactivity; male; nonhuman; pancreas; pancreas islet; pancreas tissue; pancreatic duct; pancreatitis; pathophysiology; vitamin D metabolism | English | Final | 2023 | 10.3389/fvets.2023.1265203 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Fabrication of Gastro-Floating Famotidine Tablets: Hydroxypropyl Methylcellulose-Based Semisolid Extrusion 3D Printing | Semisolid extrusion (SSE) three-dimensional (3D) printing uses drug-loaded paste for the printing process, which is capable of constructing intricate 3D structures. This research presents a unique method for fabricating gastro-floating tablets (GFT) using SSE. Paste-loaded famotidine with a matrix made of hydroxypropyl methylcellulose (HPMC) were prepared. Nine 3D printed tablets were developed with different HPMC concentrations and infill percentages and evaluated to determine their physicochemical properties, content uniformity, dissolution, and floating duration. The crystallinity of the drug remained unchanged throughout the process. Dissolution profiles demonstrated the correlation between the HPMC concentration/infill percentage and drug release behavior over 10 h. All the fabricated GFTs could float for 10 h and the Korsmeyer-Peppas model described the dissolution kinetics as combination of non-Fickian or anomalous transport mechanisms. The results of this study provided insight into the predictability of SSE 3D printability, which uses hydro-alcoholic gel-API blend materials for GFTs by controlling traditional pharmaceutical excipients and infill percentages. SSE 3D printing could be an effective blueprint for producing controlled-release GFTs, with the additional benefits of simplicity and versatility over conventional methods. | Yang, Hyun Seok; Kim, Dong Wuk | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Vessel Organ Interact Res Ctr VOICE,MRC,BK21 FOUR, Daegu 41566, South Korea | 57949331800; 57193445049 | dkim17@knu.ac.kr; | PHARMACEUTICS | PHARMACEUTICS | 1999-4923 | 15 | 2 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 4.9 | 12.9 | 1.59 | 2025-06-25 | 20 | 10 | hydroxypropyl methylcellulose; famotidine; semisolid extrusion 3D printing; gastroretentive floating system; dissolution kinetics | DRUG-DELIVERY SYSTEMS; SUSTAINED-RELEASE; COMPLEXATION; FORMULATION; IMMEDIATE; BEHAVIOR; DOSAGE | dissolution kinetics; famotidine; gastroretentive floating system; hydroxypropyl methylcellulose; semisolid extrusion 3D printing | famotidine; hydroxypropylmethylcellulose; lactose; microcrystalline cellulose; phosphoric acid; Article; differential scanning calorimetry; dissolution; drug release; flow rate; Fourier transform infrared spectroscopy; high performance liquid chromatography; human; kinetics; nanofabrication; physical chemistry; scanning electron microscopy; stereolithography; tablet friability; three dimensional printing; X ray powder diffraction | English | 2023 | 2023-02 | 10.3390/pharmaceutics15020316 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Fatal insulin overdose in a dog with type 1 diabetes mellitus-characteristics and successful management | Administering more than 10 times the therapeutic dose of insulin is extremely rare in diabetic dogs and is life threatening with hypoglycemia and seizures if not accompanied by appropriate treatment. A 15-year-old, castrated male miniature poodle dog managed for diabetes presented with depression, disorientation, ataxia, and cluster seizures. The dog had been administered 11.1 U/kg of neutral protamine hegadorn (NPH) insulin (10 times the prescribed dose) 3 h before the onset of symptoms. Blood analysis revealed hypoglycemia, with a circulating glucose level of <50 mg/dL. To treat the hypoglycemia-induced seizures, dextrose was repeatedly administered intravenously. Repeated generalized seizures were treated with anticonvulsants and intermittent mannitol. Since refractory hypoglycemia persisted 24 h after the insulin overdose, it was decided to proceed with glucagon treatment (15-30 ng/kg/min titrated to the blood glucose level after a loading dose of 50 ng/kg intravenous bolus infusion). After 37 h of glucagon treatment, blood glucose levels stabilized. After entering a hyperglycemic state, NPH insulin was administered to manage insulin-dependent diabetes mellitus. This is the first case documented of successful treatment with glucagon, anticonvulsants and intermittent mannitol for refractory hypoglycemia and seizure caused by fatal insulin overdose. Thus, it has great clinical value in veterinary medicine. | Park, Jun-Hyeong; An, Ju-Hyun; Kim, Se-Hoon; Choi, Han-Sol; Kim, Tae-Hyeon; Oh, Ye-In; Seo, Kyoung-Won; Youn, Hwa-Young | Seoul Natl Univ, Coll Vet Med, Dept Vet Clin Sci, Lab Vet Internal Med, Seoul, South Korea; Kangwon Natl Univ, Coll Vet Med, Dept Vet Emergency & Crit Care Med, Chuncheon Si, South Korea; Kangwon Natl Univ, Inst Vet Sci, Coll Vet Med, Chuncheon Si, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daegu, South Korea | ; Seo, Kwang/AAB-4821-2020; Kim, TaeHyeon/JOK-7558-2023 | 57697530200; 57206839650; 57195692738; 58696866400; 57990225700; 36466903200; 8833507700; 7102027331 | hyyoun@snu.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 0 | 2025-06-25 | 0 | 0 | dog; glucagon; hypoglycemia; NPH; mannitol | INDUCED HYPOGLYCEMIA; BRAIN-DAMAGE; GLUCAGON; GLARGINE; INFUSION; THERAPY | dog; glucagon; hypoglycemia; mannitol; NPH | glucagon; glucose; isophane insulin; levetiracetam; mannitol; midazolam; oral antidiabetic agent; animal experiment; animal model; Article; ataxia; blood analysis; controlled study; disease severity; disorientation; drug megadose; emergency ward; glucose level; hyperglycemia; hypoglycemia; insulin dependent diabetes mellitus; insulin treatment; loading drug dose; male; medical history; nonhuman; seizure | English | 2023 | 2023-10-31 | 10.3389/fvets.2023.1255701 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | First report of Cryptosporidium andersoni and risk factors associated with the occurrence of Cryptosporidium spp. in pre-weaned native Korean calves with diarrhea | Cryptosporidium spp. are important enteric protozoan parasites that infect humans and other animals throughout the world. Cryptosporidium infection in cattle industry leads to substantial economic losses due to diarrhea, growth retardation, weight loss, and possibly death. Most studies have focused on C. parvum, and studies on other Cryptosporidium spp. and calf diarrhea are limited. Therefore, this study aimed to investigate the occurrence of Cryptosporidium spp. in pre-weaned calves, to determine the risk factors for Cryptosporidium spp. infection such as age and season, and to identify subtypes of C. parvum circulating in the Republic of Korea (ROK). A total of 510 fecal samples were collected from calves with diarrhea and divided by age and season. Cryptosporidium spp. were first screened using PCR targeting the small subunit (SSU) rRNA gene and further the 60-kDa glycoprotein gene for subtyping of C. parvum. Out of 510 fecal samples, 71 (13.9%) were positive for Cryptosporidium spp. in pre-weaned calves with diarrhea. C. andersoni (2.8%), C. bovis (30.9%), C. parvum (29.6%), and C. ryanae (36.6%) were identified. C. ryanae was the most predominant in calves in the ROK. Calf age was a significant risk factor for C. bovis (chi(2) = 13.83, P = 0.001), C. parvum (chi(2) = 7.57, P = 0.023), and C. ryanae (chi(2) = 20.18, P = 0.000) occurrence. Additionally, C. parvum was detected 3.1-fold more frequently in pre-weaned calves with diarrhea in fall (95% CI: 1.23-7.81; P = 0.016) than in spring, whereas C. ryanae was 8.9-fold more frequently detected in summer (95% CI: 1.65-48.68; P = 0.011) than in spring. Three subtypes (IIaA17G4R1, IIaA18G3R1, and IIaA20G3R1) of C. parvum were identified. Of them, IIaA17G4R1 was the most common, whereas IIaA20G3R1 was not previously detected in calves in the ROK. To our knowledge, this is the first report of C. andersoni in pre-weaned calves in the ROK. The occurrence of Cryptosporidium spp. appears to be age-dependent in calves. Season had a significant effect on the occurrence of C. parvum and C. ryanae. Taken together, C. bovis and C. ryanae along with C. parvum are detected in pre-weaned calves with diarrhea and these two pathogens should not be overlooked in the diagnosis of calf diarrhea. | Jang, Dong-Hun; Cho, Hyung-Chul; Park, Yu-Jin; Park, Jinho; Choi, Kyoung-Seong | Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Anim Sci & Biotechnol, Sangju, South Korea; Jeonbuk Natl Univ, Coll Vet Med, Iksan, South Korea | 57219426751; 57219427000; 57219426539; 8730126700; 7403949556 | kschoi3@knu.ac.kr; | FRONTIERS IN VETERINARY SCIENCE | FRONT VET SCI | 2297-1769 | 10 | SCIE | VETERINARY SCIENCES | 2023 | 2.6 | 12.9 | 2.58 | 2025-06-25 | 6 | 7 | Cryptosporidium spp; diarrhea; pre-weaned calves; age; season | N. SP APICOMPLEXA; DAIRY-CATTLE; MOLECULAR CHARACTERIZATION; GIARDIA-DUODENALIS; WATER SOURCES; PREVALENCE; INFECTION; PARVUM; GENOTYPES; HUMANS | age; Cryptosporidiumspp; diarrhea; pre-weaned calves; season | genomic DNA; glycoprotein; Article; autumn; calf (bovine); coinfection; controlled study; cryptosporidiosis; Cryptosporidium; Cryptosporidium andersoni; Cryptosporidium bovis; Cryptosporidium parvum; Cryptosporidium ryanae; diarrhea; DNA extraction; feces analysis; microorganism detection; nonhuman; risk factor; South Korea; spring; summer; winter | English | 2023 | 2023-03-21 | 10.3389/fvets.2023.1145096 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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