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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article Pre-drought effects on northern temperate trees and vine invasion in forest gaps hindering regeneration Northern temperate coniferous forests serve as crucial connectors between boreal and temperate forests, yet they are vulnerable to various stressors such as climate change and human activities. Severe drought poses a significant threat to plant species within these forests, prompting recent research into its impacts. However, many studies lack explicit definitions of post-disturbance vegetation processes and fail to identify potential interactions with disturbance factors, necessitating comprehensive discussions. This study examines the effects of drought on tree growth patterns of the main dominant species in northern temperate regions: Abies nephrolepis and Picea jezoensis, along with two commonly associated Betula ermanii, and Quercus mongolica. Additionally, new disturbance factors in forests inhabited by these species (A. nephrolepis and P. jezoensis) were evaluated based on community classification. The study sites were located in the Mt. Baekdu (Changbai) and South Korea regions, which are positioned at the southern limit of the phytogeographical patterns of target species. Results indicate that A. nephrolepis and P. jezoensis exhibit high levels of recovery and resilience, while B. ermanii and Q. mongolica demonstrate high resistance. Species-specific responses align with drought intensity, with resistance, recovery, and resilience decreasing notably with increasing pre-drought radial growth. South Korean forests, the invasion of the vine species Tripterygium regelii after the death of A. nephrolepis in the overstory vegetation threatens the regeneration of new trees. However, certain environmental factors, such as high rock exposure and dense overstory canopy, limit vine invasion. Based on the results, pre-drought radial growth emerges as a key determinant in how trees respond to drought. Additionally, the results suggest the potential for new disturbances to emerge in forest gaps due to overstory vegetation mortality induced by global warming. These findings contribute to a deeper understanding of increasing drought stress, aid in identifying climate refugia, and inform conservation priorities based on habitat characteristics. Lee, Seung-Jae; Lee, Ah-Rim; Byeon, Jun-Gi; Oh, Seung-Hwan Kyungpook Natl Univ, Grad Sch, Dept Forestry, Daegu 41566, South Korea; Korea Arboreta & Gardens Inst, Baekdudaegan Natl Arboretum, Bonghwa 36209, South Korea; Kyungpook Natl Univ, Sch Forest Sci & Landscape Architecture, Daegu 41566, South Korea 58500067400; 58296422900; 58002350300; 57026695200 oshwan@knu.ac.kr; SCIENCE OF THE TOTAL ENVIRONMENT SCI TOTAL ENVIRON 0048-9697 1879-1026 951 SCIE ENVIRONMENTAL SCIENCES 2024 8 10.3 0 2025-05-07 0 0 Pre-drought radial growth; Growth response patterns; Forest regeneration; Disturbance; Temperate forests; Vine invasion ALPINE PLANT-COMMUNITIES; CLIMATE-CHANGE; ABIES-NEPHROLEPIS; GROWTH-RESPONSES; PICEA-JEZOENSIS; NORWAY SPRUCE; PINE; VULNERABILITY; BIODIVERSITY; DISTURBANCES Disturbance; Forest regeneration; Growth response patterns; Pre-drought radial growth; Temperate forests; Vine invasion Abies; China; Climate Change; Droughts; Forests; Introduced Species; Picea; Quercus; Republic of Korea; Trees; Baekdu Mountain; Changbai Mountains; South Korea; Abiotic; Anthropogenic; Plant diseases; Disturbance; Forest gaps; Forest regeneration; Growth response; Growth response pattern; Pre-drought radial growth; Radial-growth; Response patterns; Temperate forests; Vine invasion; biological invasion; coniferous tree; disturbance; drought stress; growth response; refugium; regeneration; temperate forest; vegetation; vine; Abies; Article; birch; canopy; climate change; climbing plant; community dynamics; disease severity; drought; drought stress; ecosystem regeneration; environmental factor; evapotranspiration; forest; geographic distribution; greenhouse effect; habitat; heat stress; mortality; photosynthesis; plant community; Quercus mongolica; refugium; regeneration; rock; sea surface temperature; seasonal variation; South Korea; species richness; spruce; temperate deciduous forest; tree; tree growth; Tripterygium; vegetation; work environment; China; climate change; growth, development and aging; introduced species; oak; physiology; Forest ecology English 2024 2024-11-15 10.1016/j.scitotenv.2024.175707 바로가기 바로가기 바로가기 바로가기
Article Strategic Atomic Interaction Modification for Highly Durable Inorganic Solid Electrolytes in Advanced All-Solid-State Li-Metal Batteries All-solid-state Li-metal battery (ASSLB) represents advantageous energy storage system for automotive applications. For ASSLB, inorganic solid electrolyte is essential in determining safety and cycling performance. However, significant challenges persist in practical construction of ASSLB with optimized electrolyte. Specifically, electrolyte's structural instability influencing its electrochemical performance remains critical issue within typical operating temperatures for ASSLB in electric vehicles. Herein, this challenge is fundamentally addressed by substituting trace amount of lithium with cadmium, which lacks crystal field stabilization energy. This strategy of atomic interaction modification has induced electrolyte's structural distortion and electronic alteration by deliberately introducing disorder at local lithium sites. Li symmetric cell with cadmium-substituted antiperovskite solid electrolyte exhibits outstanding critical current density of 11.5 mA cm-2 (5.75 mAh cm-2) and excellent stability for 3000 h at 10.0 mA cm-2 (5.0 mAh cm-2). This study highlights explicit research direction for breakthrough of ASSLB, focusing on understanding how local distortion affects complex inorganic materials. All-solid-state Li-metal batteries (ASSLBs) offer enhanced safety and energy density over conventional batteries. However, intrinsic structural instability of solid electrolytes deters ASSLB performance at the typical operating temperatures of electric vehicles. Herein, the substantial merit of a stabilization strategy for the electrolytes is unveiled by modifying atomic interactions with a metal ion that lacks crystal field stabilization energy.image (c) 2024 WILEY-VCH GmbH Kim, Heebae; Jang, Eunbin; Cho, Jinil; Pyo, Seonmi; Yun, Heejun; Lee, Jeewon; Min, Byeongyun; Han, Juyeon; Yoo, Jeeyoung; Kim, Youn Sang Seoul Natl Univ, Coll Engn, Dept Chem & Biol Engn, 1 Gwanak Ro, Seoul 08826, South Korea; Seoul Natl Univ, Inst Chem Proc, Coll Engn, 1 Gwanak Ro, Seoul 08826, South Korea; Kyungpook Natl Univ, Sch Energy Engn, 80 Daehak Ro, Daegu 41566, South Korea; Samsung SDI Co Ltd, 130 Samsung Ro, Suwon 16678, South Korea; Hyundai Motor Grp, Uiwang Si 16082, Gyeonggi Do, South Korea; Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Program Nano Sci & Technol, 1 Gwanak Ro, Seoul 08826, South Korea; Adv Inst Convergence Technol, 145 Gwanggyo Ro, Suwon 16229, South Korea Yoo, Jeeyoung/AAH-1359-2019; Kim, SoW/ABB-7917-2021; Cho, Hyuk/AAU-7753-2020 57217054648; 57837176500; 57209801309; 57211858131; 57218197755; 57339274800; 58018081000; 57222146622; 56046607500; 8938854200 jyoo@knu.ac.kr;younskim@snu.ac.kr; SMALL STRUCTURES SMALL STRUCT 2688-4062 5 9 SCIE CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY 2024 11.3 10.3 0.82 2025-05-07 2 2 all-solid-state batteries; cation substitution; crystal field stabilization energy; inorganic solid electrolytes; interface compatibility; Li-metal anodes; structural modification DESIGN; ION all-solid-state batteries; cation substitution; crystal field stabilization energy; inorganic solid electrolytes; interface compatibility; Li-metal anodes; structural modification English 2024 2024-09 10.1002/sstr.202400091 바로가기 바로가기 바로가기 바로가기
Article Surveillance of Vector-Borne Zoonotic Diseases in South Korea: Uncovering Novel Pathogen Carriers Among Rodents and Mites Nationwide Wild rodents and their ectoparasites are known reservoirs for various zoonotic pathogens, highlighting the need for detailed studies into their roles in disease transmission. Our research investigated the spatial distribution of rodents and their ectoparasites to better understand the epidemiology of vector-borne zoonotic diseases (VBZDs), including severe fever with thrombocytopenia syndrome (SFTS), Lyme disease, Q fever, and scrub typhus. We analyzed samples from 540 rodents and 6785 mites, detecting the presence of Borrelia spp., the causative agent of Lyme disease, in 0.9% of rodents and SFTS virus (SFTSV) in 1.0%. In mites, Borrelia spp. and Orientia tsutsugamushi, the bacteria causing scrub typhus, were detected in 0.3% of samples each. Phylogenetic analysis identified the SFTSV sequence as type B3, the Borrelia spp. sequence as B. afzelii, and the O. tsutsugamushi sequence as Karp-related. Notably, SFTSV was detected for the first time in mites in South Korea, and B. afzelii was found in mites for the first time globally. These findings emphasize the critical need for continuous analysis of VBZDs to anticipate future trends and develop a comprehensive monitoring system. Further research into the rodent and mite populations in South Korea is essential to fully assess the potential risks of VBZDs. Kim, Beoul; Lee, You-Jeong; Lee, Hee Il; Kwak, Dongmi; Seo, Min-Goo Kyungpook Natl Univ, Coll Vet Med, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Vet Biomed Sci, 80 Daehak Ro, Daegu 41566, South Korea; Korea Dis Control & Prevent Agcy, Div Vectors & Parasit Dis, 187 Osongsaenmyeong2 Ro, Cheongju 28159, South Korea ; Seo, Min-Goo/NQF-4335-2025 59343608800; 59343760600; 7501477904; 7007148758; 53982155300 kbjjhnm@naver.com;wowgirlsgood@naver.com;isak@korea.kr;dmkwak@knu.ac.kr;koreasmg@knu.ac.kr; TRANSBOUNDARY AND EMERGING DISEASES TRANSBOUND EMERG DIS 1865-1674 1865-1682 2024 SCIE INFECTIOUS DISEASES;VETERINARY SCIENCES 2024 3 10.3 0 2025-05-07 1 1 Lyme disease; mite; Q fever; scrub typhus; SFTS; wild rodent THROMBOCYTOPENIA SYNDROME VIRUS; BURGDORFERI-SENSU-LATO; COXIELLA-BURNETII; SEVERE FEVER; ORIENTIA-TSUTSUGAMUSHI; BORRELIA-BURGDORFERI; SMALL MAMMALS; SCRUB TYPHUS; TICKS; RESERVOIRS Lyme disease; mite; Q fever; scrub typhus; SFTS; wild rodent Animals; Borrelia; Mites; Orientia tsutsugamushi; Phlebovirus; Phylogeny; Republic of Korea; Rodent Diseases; Rodentia; Vector Borne Diseases; Zoonoses; Article; controlled study; ectoparasite; liver tissue; Lyme disease; mite; monitoring; nonhuman; Orientia tsutsugamushi; phylogeny; Q fever; reverse transcription polymerase chain reaction; rodent; scrub typhus; severe fever with thrombocytopenia syndrome; South Korea; vector borne zoonotic disease; zoonosis; animal; Borrelia; epidemiology; genetics; isolation and purification; microbiology; parasitology; Phlebovirus; rodent disease; South Korea; vector borne disease; veterinary medicine; virology English 2024 2024-11-08 10.1155/2024/5544660 바로가기 바로가기 바로가기 바로가기
Article Utilizing fluorescence indicators to apportion organic sources in estuarine/coastal sediments: A comparison with a stable isotopic model Coastal sediments accumulate organic matter (OM) from diverse sources, including local anthropogenic pollution. Effective source tracking of sediment OM is crucial for pollution source management. This study compares fluorescence proxies and stable isotopic ratios as tracers for sediment OM in Gangu Port, Korea. An optimized extraction method using distilled water for 0.5 h yielded distinct fluorescence signatures. The humification index (HIX) and protein-like component (C3%) showed ideal mixing behavior with two end-members (fishery market sediment and algae). A Bayesian end-member mixing analysis model revealed that agricultural soil is the prevalent contributor to sediments, aligning with land use patterns. The fluorescence-based model showed higher sensitivity to anthropogenic influences compared to traditional stable isotope ratios. The results strongly agreed with isotope ratio-based predictions, exhibiting a positive correlation (p < 0.05) at 8 out of 14 sites. This study highlights the potential of fluorescence-based tracking to complement or replace conventional stable isotope methods. © 2024 Elsevier B.V. Badalge, Nipuni Dineesha Kandaddara; Choi, Na Eun; Shin, Kyung-Hoon; Cho, Yusang; Kim, Sunghwan; Oh, Neung-Hwan; Hur, Jin Department of Environment and Energy, Sejong University, Seoul, 05006, South Korea; Department of Environment and Energy, Sejong University, Seoul, 05006, South Korea; Department of Marine Science and Convergence Engineering, Hanyang University, Gyeonggi-do, Ansan, 15588, South Korea; Department of Marine Science and Convergence Engineering, Hanyang University, Gyeonggi-do, Ansan, 15588, South Korea; Department of Chemistry, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; Department of Environmental Planning, Graduate School of Environmental Studies, Seoul National University, Seoul, 08826, South Korea, Environmental Planning Institute, Seoul National University, Seoul, 08826, South Korea; Department of Environment and Energy, Sejong University, Seoul, 05006, South Korea 59388300000; 58971989500; 57201420612; 57998478700; 57203772967; 7004516461; 7005096817 shinkh@hanyang.ac.kr; Science of the Total Environment SCI TOTAL ENVIRON 0048-9697 1879-1026 955 SCIE ENVIRONMENTAL SCIENCES 2024 8 10.3 0 2025-05-07 0 Coastal sediment; Dissolved organic matter; End-member mixing; Fluorescence; Source tracking China; Gangu; Gansu; Biotic; brackish water; carbon; deionized water; dissolved organic matter; fertilizer; isotope; nitrogen; particulate organic matter; soil organic matter; A-stable; Coastal sediments; Dissolved organic matters; End member mixing; Estuarine coastal; Fluorescence indicators; Organic sources; Organics; Sediment organic matters; Source tracking; atmospheric pollution; comparative study; dissolved organic matter; estuarine sediment; fluorescence; organic matter; port operation; source apportionment; stable isotope; tracking; aquatic environment; Article; Chlorella vulgaris; ecosystem; fluorescence; fluorescence intensity; green alga; humic substance; humification; nonhuman; pollution; wastewater; Haze pollution English Final 2024 10.1016/j.scitotenv.2024.177086 바로가기 바로가기 바로가기
Article Activation of Nuclear Factor Erythroid 2-Related Factor-2 by Oxylipin from Mangifera indica Leaves Mangifera indica L., a member of the Anacardiaceae family, is widely cultivated across the globe. The leaves of M. indica are renowned for their medicinal properties, attributed to the abundance of bioactive compounds. This study investigated the effects of mango leaf extract on oxidative stress in HeLa cells. Notably, the n-hexane fraction (MLHx) significantly enhanced antioxidant response element (ARE)-luciferase activity at a concentration of 100 mu g/mL, surpassing other fractions. MLHx also promoted the expression of HO-1 mRNA by increasing nuclear NRF2 levels. The molecular mechanism of MLHx involves increased phosphorylation of ERK1/2 and stabilization of NRF2. Bioactivity-guided isolation resulted in the identification of six oxylipins: 13(R)-hydroxy-octadeca-(9Z,11E,15Z)-trienoic acid (C-1), 9(R)-hydroxy-octadeca-(10E,12Z,15Z)-trienoic acid (C-2), 13(R)-hydroxy-(9Z,11E)-octadecadienoic acid (C-3), 9(R)-hydroxy-(10E,12Z)-octadecadienoic acid (C-4), 9-oxo-(10E,12E)-octadecadienoic acid (C-5), and 9-oxo-(10E,12Z)-octadecadienoic acid (C-6). These structures were elucidated using comprehensive spectroscopic techniques, including MS and 1H NMR. Additionally, compounds C-7 (9-oxo-(10E,12Z,15Z)-octadecatrienoic acid) and 8 (13-oxo-(9E,11E)-octadecadienoic acid) were characterized by LC-MS/MS mass fragmentation. This study reports the isolation of compounds 1-6 from M. indica for the first time. When tested for their effect on NRF2 activity in HeLa cells, compounds 3, 5, and 6 showed strong stimulation of ARE-luciferase activity in a dose-dependent manner. Khalil, Atif Ali Khan; Woo, Min-Seok; Kang, Dong-Min; Ahn, Mi-Jeong; Kim, Jeong-Ah; Yang, Heejung; Kim, Jung-Hwan Gyeongsang Natl Univ, Inst Hlth Sci, Sch Med, Dept Pharmacol, Jinju 52727, South Korea; Gyeongsang Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Jinju 52828, South Korea; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Kangwon Natl Univ, Coll Pharm, Chunchon 24341, South Korea Khalil, Atif/AAM-2573-2020 57197792859; 57201074693; 57214895690; 22949791800; 24722570900; 37032444100; 57203325580 atif.ali@gnu.ac.kr;minseokwoo@gnu.ac.kr;kdm7105@gnu.ac.kr;amj5812@gnu.ac.kr;jkim6923@knu.ac.kr;heejyang@kangwon.ac.kr;junghwan.kim@gnu.ac.kr; ANTIOXIDANTS ANTIOXIDANTS-BASEL 2076-3921 13 9 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY 2024 6.6 10.4 0 2025-05-07 0 1 NRF2; Mangifera indica L.; fatty oxylipin; antioxidant; ubiquitination ANTIOXIDANT RESPONSE ELEMENT; PROTEIN-KINASE-C; TRANSCRIPTIONAL ACTIVATION; SIGNALING PATHWAY; NRF2; ACID; ACCUMULATION; KEAP1; PHOSPHORYLATION; CHEMOPREVENTION antioxidant; fatty oxylipin; Mangifera indicaL; NRF2; ubiquitination English 2024 2024-09 10.3390/antiox13091119 바로가기 바로가기 바로가기 바로가기
Article Augmenting Rice Defenses: Exogenous Calcium Elevates GABA Levels Against WBPH Infestation This study investigates the impact of exogenous calcium and gamma-aminobutyric acid (GABA) supplementation on rice growth and stress tolerance under white-backed planthopper (WBPH) infestation. We evaluated several phenotypic traits, including shoot/root length, leaf width, tiller number, panicle length, and relative water content, alongside physiological markers such as oxidative stress indicators, antioxidant enzymes activities, hormonal levels, and amino acids biosynthesis. Our results indicate that WBPH stress significantly reduces growth parameters but calcium and GABA supplementation markedly enhance shoot length (by 26% and 36%) and root length (by 38% and 64%), respectively, compared to WBPH-infested plants. Both supplementations also reduced oxidative stress, as evidenced by decreased H2O2 and O2 center dot- levels and a lower electrolyte leakage. Notably, calcium and GABA treatments increased antioxidant enzyme activities, with GABA boosting catalase (CAT) activity by 800%, peroxidase (POD) by 144%, and superoxide dismutase (SOD) by 62% under WBPH stress. Additionally, calcium and GABA enhanced the accumulation of stress hormones (abscisic acid ABA) and salicylic acid (SA) and promoted stomatal closure, contributing to improved water conservation. This study reveals that calcium regulates the GABA shunt pathway, significantly increasing GABA and succinate levels in both root and shoot. Furthermore, calcium and GABA supplementation enhance the biosynthesis of key amino acids and improve ion homeostasis, particularly elevating calcium (Ca), iron (Fe), and magnesium (Mg) levels under WBPH stress. Overall, this study highlights the potential of exogenous calcium and GABA as effective strategies for enhancing rice plant tolerance to WBPH infestation by modulating various physiological and biochemical mechanisms. Further research is warranted to fully elucidate the underlying mechanisms of action. Jan, Rahmatullah; Asaf, Sajjad; Lubna, Muhammad; Farooq, Muhammad; Asif, Saleem; Khan, Zakirullah; Park, Jae-Ryoung; Kim, Eun-Gyeong; Jang, Yoon-Hee; Kim, Kyung-Min Kyungpook Natl Univ, Grad Sch, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Jeonbuk Natl Univ, Coll Agr & Life Sci, Dept Agr Biol, Jeonju 54896, South Korea; Rural Dev Adm, Natl Inst Crop Sci, Crop Breeding Div, Wanju 55365, South Korea; Natl Inst Agr Sci, Rural Dev Adm, Natl Agrobiodivers Ctr, Jeonju 54874, South Korea; Natl Inst Agr Sci, Rural Dev Adm, Gene Engn Div, Jeonju 54874, South Korea ; Kim, Kyung-Min Kim/C-7007-2014; Jan, Rahmatullah/LFU-1421-2024; Asaf, Sajjad/ABA-3647-2021 57201981969; 56595059900; 57200621537; 59899372800; 57396413700; 58810294300; 57211205505; 57221496070; 57219901992; 34868260300 zakirullah371@gmail.com;kkm@knu.ac.kr;rahmat2021@knu.ac.kr; ANTIOXIDANTS ANTIOXIDANTS-BASEL 2076-3921 13 11 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY 2024 6.6 10.4 0 2025-05-07 1 1 calcium; gamma-aminobutyric acid; white-backed planthopper; oxidative stress; antioxidant activity; hormones GAMMA-AMINOBUTYRIC-ACID; SOGATELLA-FURCIFERA; RESISTANCE; ACCUMULATION; MAGNESIUM; STRESS; TEMPERATURE; METABOLITES; INHIBITION; HERBIVORY antioxidant activity; calcium; gamma-aminobutyric acid; hormones; oxidative stress; white-backed planthopper English 2024 2024-11 10.3390/antiox13111321 바로가기 바로가기 바로가기 바로가기
Article CoFe2O4-BaTiO3 core-shell-embedded flexible polymer composite as an efficient magnetoelectric energy harvester Flexible magnetoelectric (ME) generators gained immense interest due to the broad applications in wearable and Internet of Things (IoT)-based devices. The key to achieving high energy conversion performance of 0-3 type ME composite films is the prevention of filler aggregation in the polymer matrix and accessing the full potential of intrinsic properties of filler. To achieve high performance, a flexible ME composite film was fabricated by homogeneous distribution of magnetostrictive CoFe2O4-BaTiO3 core-shell (CBCS) fillers into piezoelectric polyvinylidene fluoride (PVDF) polymer. The ME composite film generates an enhanced energy conversion efficiency by optimizing the shell thickness of CBCS and maximizing the electroactive beta-phase at the BaTiO3 shell-PVDF interfacial region. The observed ME coefficient of the film reached up to 710 mV/cm center dot Oe. Multiphysics simulations based on the finite element analysis were adopted to investigate the role of BaTiO3 shell thickness on the performance of ME film. This study paves the way to achieve higher filler loading content in the ME composite films to develop an efficient, flexible ME generator for eco-friendly permanent power sources. Bae, Bitna; Alluri, Nagamalleswara Rao; Kim, Cheol Min; Ryu, Jungho; Kim, Gwang Hyeon; Park, Hyeon Jun; Baek, Changyeon; Lee, Min-Ku; Lee, Gyoung-Ja; Hwang, Geon-Tae; Park, Kwi-Il Kyungpook Natl Univ, Dept Mat Sci & Met Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Innovat Semicond Educ & Res Ctr Future Mobil, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Automot Parts & Mat, Daegu 41566, South Korea; Yeungnam Univ, Sch Mat Sci & Engn, Gyongsan 38541, Gyeongsangbuk D, South Korea; Korea Atom Energy Res Inst, Nucl Syst Integr Sensing & Diag Res Div, Daejeon 34057, South Korea; Pukyong Natl Univ, Dept Mat Sci & Engn, Busan 48513, South Korea Park, Kwiil/LKN-9445-2024; Alluri, Nagamalleswara Rao/K-1696-2015; Ryu, Jungho/LXU-4081-2024 59302327300; 56527074500; 59441985400; 57201603501; 59303138700; 58859176900; 57095549400; 59302175900; 8588965200; 36704574900; 35280874200 leegj@kaeri.re.kr;gthwang@pknu.ac.kr;kipark@knu.ac.kr; MATERIALS TODAY PHYSICS MATER TODAY PHYS 2542-5293 48 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED 2024 9.7 10.4 2.32 2025-05-07 7 9 Magneto-Mechano-electric conversion; Flexible; Energy harvesting; Piezoelectric; CoFe 2 O 4 -BaTiO 3 core shell NANOPARTICLES; BEHAVIOR; FILMS CoFe<sub>2</sub>O<sub>4</sub>-BaTiO<sub>3</sub> core shell; Energy harvesting; Flexible; Magneto-Mechano-electric conversion; Piezoelectric Elastomers; Energy conversion efficiency; Energy harvesting; Glass ceramics; Hard facing; Ionomers; Magnetostrictive devices; BaTiO 3; Cofe2O4-BaTiO3 core shell; Core shell; Electric conversion; Energy; Flexible; Magneto-mechano-electric conversion; Magnetoelectric composites; Magnetoelectrics; Piezoelectric; Piezoelectricity English 2024 2024-11 10.1016/j.mtphys.2024.101567 바로가기 바로가기 바로가기 바로가기
Article Congenital Anomalies in Multiple Pregnancy: A Literature Review ImportanceMultiple pregnancy is relatively common in many countries and is associated with various pregnancy complications, including preterm birth, low birth weight, and congenital anomalies. In particular, a poorer prognosis has been reported when congenital anomalies overlap with other pregnancy complications in multiple pregnancy compared with singleton pregnancy.ObjectiveThis study reviews the characteristics of congenital anomalies that occur in multiple gestations as compared with singleton pregnancies.Evidence AcquisitionAn extensive manual search of major electronic databases was conducted in June 2023. This literature review provides a comprehensive coverage of the congenital anomalies in multiple pregnancy.ResultsMost studies have shown that multiple gestations are associated with an increased risk of congenital anomalies compared with singleton pregnancies. In addition, higher rates of congenital anomalies and concordance have been observed in monozygotic versus dizygotic twins. The effect of assisted reproductive therapies on the risk of congenital anomalies appears to be smaller in multiple gestations than in singleton pregnancies.ConclusionsMultiple pregnancy is significantly associated with an increased risk of congenital anomalies.RelevanceThis review provides obstetrical providers with the requisite knowledge to offer appropriate antenatal care and prenatal anomaly screening to patients with multiple pregnancies.Target AudienceObstetrics and gynecology specialists and family physicians.Learning ObjectivesAfter participating in this activity, the learners should be better able to explain the prevalence and trend of congenital anomalies in multiple pregnancy; describe the importance of zygosity in prevalence and concordance in multiple pregnancy; and describe the effect of assisted reproductive therapies on the risk of congenital anomalies. Shin, Jae Eun; Ko, Hyun Sun; Bae, Jin Young; Seong, Won Joon; Ahn, Tae Gyu; Han, You Jung; Cho, Geum Joon; Park, In Yang Catholic Univ Korea, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Catholic Univ Daegu, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kangwon Natl Univ, Sch Med, Dept Obstet & Gynecol, Chunchon, South Korea; CHA Univ, Sch Med, CHA Gangnam Med Ctr, Dept Obstet & Gynecol, Seoul, South Korea; Korea Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Obstet & Gynecol, 222 Banpo Daero, Seoul 06591, South Korea Han, You/W-3659-2019 58305399000; 37026301100; 57201130049; 26656946000; 56781022400; 54779769400; 12545334500; 58939324900 jennie1008@catholic.ac.kr;mongkoko@catholic.ac.kr;duchess7@hanmail.net;wjseong@knu.ac.kr;ahntg@naver.com;hanyj1978@hanmail.net;md_cho@hanmail.net;ooooobbbbb@catholic.ac.kr; OBSTETRICAL & GYNECOLOGICAL SURVEY OBSTET GYNECOL SURV 0029-7828 1533-9866 79 3 SCIE OBSTETRICS & GYNECOLOGY 2024 3.6 10.4 0.42 2025-05-07 1 1 ASSISTED REPRODUCTIVE TECHNOLOGY; STRUCTURAL BIRTH-DEFECTS; UNITED-STATES; TWINS; MALFORMATIONS; RISK; TRENDS; PREVALENCE; RATES; METAANALYSIS Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Pregnancy, Multiple; Premature Birth; Prenatal Care; Prenatal Diagnosis; congenital malformation; dizygotic twins; human; infertility therapy; live birth; monozygotic twins; multiple pregnancy; newborn death; pregnancy; pregnancy rate; prevalence; Review; risk factor; singleton pregnancy; stillbirth; twin concordance; zygosity; female; multiple pregnancy; newborn; pregnancy complication; prematurity; prenatal care; prenatal diagnosis English 2024 2024-03 10.1097/ogx.0000000000001251 바로가기 바로가기 바로가기 바로가기
Article Delay-dependent Lurie-Postnikov type Lyapunov-Krasovskii functionals for stability analysis of discrete-time delayed neural networks This paper addresses the influence of time-varying delay and nonlinear activation functions with sector restrictions on the stability of discrete-time neural networks. Compared to previous works that mainly focuses on the influence of delay information, this paper devotes to activation nonlinear functions information to help compensate the analysis technique based on Lyapunov-Krasovskii functional (LKF). A class of delay-dependent Lurie-Postnikov type integral terms involving sector constraints of nonlinear activation function is proposed to complement the LKF construction. The less conservative criteria for the stability analysis of discrete-time delayed networks is given by using improved LKF. Numerical examples show that conservatism can be reduced by the delay-dependent integral terms involving nonlinear activation functions. Xie, Ke-You; Zhang, Chuan-Ke; Lee, Sangmoon; He, Yong; Liu, Yajuan China Univ Geosci, Sch Automat, Wuhan 430074, Peoples R China; Hubei Key Lab Adv Control & Intelligent Automat Co, Wuhan 430074, Peoples R China; Minist Educ, Engn Res Ctr Intelligent Technol Geoexplorat, Wuhan 430074, Peoples R China; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; North China Elect Power Univ, Sch Control & Comp Engn, Beijing 102206, Peoples R China Lee, Sangmoon/C-4502-2018; Xie, Ke-You/HHS-5859-2022; He, Yong/Y-6866-2019; Yajuan, Liu/JZD-8537-2024; Zhang, Chuan-Ke/L-7727-2016 57211609242; 55557210100; 59510733500; 55570599300; 55255775300 moony@knu.ac.kr; NEURAL NETWORKS NEURAL NETWORKS 0893-6080 1879-2782 173 SCIE COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;NEUROSCIENCES 2024 6.3 10.4 1.05 2025-05-07 3 4 Discrete-time neural network; Stability; Time-varying delay; Lyapunov-Krasovskii functional (LKF); Delay-dependent integral terms STATE ESTIMATION; SYSTEMS; SECTOR; CRITERION Delay-dependent integral terms; Discrete-time neural network; Lyapunov–Krasovskii functional (LKF); Stability; Time-varying delay Algorithms; Neural Networks, Computer; Time Factors; Activation analysis; Neural networks; Nonlinear analysis; Stability criteria; Time delay; Time varying control systems; Time varying networks; Delay dependent; Delay-dependent integral term; Discrete time; Discrete-time neural networks; Integral terms; Lyapunov-Krasovskii's functional; Lyapunov–krasovskii functional; Nonlinear activation functions; Stability analyze; Time-varying delay; article; controlled study; discrete time neural network; human; major clinical study; nerve cell network; pharmaceutics; time delay neural network; algorithm; artificial neural network; time factor; Chemical activation English 2024 2024-05 10.1016/j.neunet.2024.106195 바로가기 바로가기 바로가기 바로가기
Article Exogenous GABA Enhances Copper Stress Resilience in Rice Plants via Antioxidant Defense Mechanisms, Gene Regulation, Mineral Uptake, and Copper Homeostasis The importance of gamma-aminobutyric acid (GABA) in plants has been highlighted due to its critical role in mitigating metal toxicity, specifically countering the inhibitory effects of copper stress on rice plants. This study involved pre-treating rice plants with 1 mM GABA for one week, followed by exposure to varying concentrations of copper at 50 mu M, 100 mu M, and 200 mu M. Under copper stress, particularly at 100 mu M and 200 mu M, plant height, biomass, chlorophyll content, relative water content, mineral content, and antioxidant activity decreased significantly compared to control conditions. However, GABA treatment significantly alleviated the adverse effects of copper stress. It increased plant height by 13%, 18%, and 32%; plant biomass by 28%, 52%, and 60%; chlorophyll content by 12%, 30%, and 24%; and relative water content by 10%, 24%, and 26% in comparison to the C50, C100, and C200 treatments. Furthermore, GABA treatment effectively reduced electrolyte leakage by 11%, 34%, and 39%, and the concentration of reactive oxygen species, such as malondialdehyde (MDA), by 9%, 22%, and 27%, hydrogen peroxide (H2O2) by 12%, 38%, and 30%, and superoxide anion content by 8%, 33, and 39% in comparison to C50, C100, and C200 treatments. Additionally, GABA supplementation led to elevated levels of glutathione by 69% and 80%, superoxide dismutase by 22% and 125%, ascorbate peroxidase by 12% and 125%, and catalase by 75% and 100% in the C100+G and C200+G groups as compared to the C100 and C200 treatments. Similarly, GABA application upregulated the expression of GABA shunt pathway-related genes, including gamma-aminobutyric transaminase (OsGABA-T) by 38% and 80% and succinic semialdehyde dehydrogenase (OsSSADH) by 60% and 94% in the C100+G and C200+G groups, respectively, as compared to the C100 and C200 treatments. Conversely, the expression of gamma-aminobutyric acid dehydrogenase (OsGAD) was downregulated. GABA application reduced the absorption of Cu2+ by 54% and 47% in C100+G and C200+G groups as compared to C100, and C200 treatments. Moreover, GABA treatment enhanced the uptake of Ca2+ by 26% and 82%, Mg2+ by 12% and 67%, and K+ by 28% and 128% in the C100+G and C200+G groups as compared to C100, and C200 treatments. These findings underscore the pivotal role of GABA-induced enhancements in various physiological and molecular processes, such as plant growth, chlorophyll content, water content, antioxidant capacity, gene regulation, mineral uptake, and copper sequestration, in enhancing plant tolerance to copper stress. Such mechanistic insights offer promising implications for the advancement of safe and sustainable food production practices. Khan, Zakirullah; Jan, Rahmatullah; Asif, Saleem; Farooq, Muhammad; Kim, Kyung-Min Kyungpook Natl Univ, Grad Sch, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea ; Jan, Rahmatullah/LFU-1421-2024; Kim, Kyung-Min Kim/C-7007-2014 58810294300; 57201981969; 57396413700; 57215544380; 34868260300 zakir371@knu.ac.kr;rahmatullah2021@knu.ac.kr;saleemasif10@knu.ac.kr;2018225016@knu.ac.kr;kkm@knu.ac.kr; ANTIOXIDANTS ANTIOXIDANTS-BASEL 2076-3921 13 6 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY 2024 6.6 10.4 1.42 2025-05-07 5 6 copper; gamma aminobutyric acid; oxidative stress; antioxidant enzymes; genes expression GAMMA-AMINOBUTYRIC-ACID; INDUCED OXIDATIVE STRESS; SPHINGOMONAS SP LK11; ORYZA-SATIVA L.; EXCESS COPPER; HYDROGEN-PEROXIDE; ORGANIC-MATTER; HEAVY-METALS; SALT STRESS; PADDY SOIL antioxidant enzymes; copper; gamma aminobutyric acid; genes expression; oxidative stress English 2024 2024-06 10.3390/antiox13060700 바로가기 바로가기 바로가기 바로가기
Article Gadolinium-Based Magnetic Resonance Theranostic Agent with Gallic Acid as an Anti-Neuroinflammatory and Antioxidant Agent Studies in the field have actively pursued the incorporation of diverse biological functionalities into gadolinium-based contrast agents, aiming at the amalgamation of MRI imaging and therapeutic capabilities. In this research, we present the development of Gd-Ga, an anti-neuroinflammatory MR contrast agent strategically designed to target inflammatory mediators for comprehensive imaging diagnosis and targeted lesion treatment. Gd-Ga is a gadolinium complex composed of 1,4,7-tris(carboxymethylaza)cyclododecane-10-azaacetylamide (DO3A) conjugated with gallic acid (3,4,5-trihydroxybenzoic acid). Upon intravenous administration in LPS-induced mouse models, Gd-Ga demonstrated a remarkable three-fold increase in signal-to-noise (SNR) variation compared to Gd-DOTA, particularly evident in both the cortex and hippocampus 30 min post-MR monitoring. In-depth investigations, both in vitro and in vivo, into the anti-neuroinflammatory properties of Gd-Ga revealed significantly reduced protein expression levels of pro-inflammatory mediators compared to the LPS group. The alignment between in silico predictions and phantom studies indicates that Gd-Ga acts as an anti-neuroinflammatory agent by directly binding to MD2. Additionally, the robust antioxidant activity of Gd-Ga was confirmed by its effective scavenging of NO and ROS. Our collective findings emphasize the immense potential of this theranostic complex, where a polyphenol serves as an anti-inflammatory drug, presenting an exceptionally efficient platform for the diagnosis and treatment of neuroinflammation. Sung, Bokyung; Hwang, Dongwook; Baek, Ahrum; Yang, Byeongwoo; Lee, Sangyun; Park, Jangwoo; Kim, Eunji; Kim, Minsup; Lee, Eunshil; Chang, Yongmin Kyungpook Natl Univ, ICT Convergence Res Ctr, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Theranocure Co Ltd, 90 Chilgokjungang Daero 136 Gil, Daegu 41405, South Korea; Kyungpook Natl Univ, Inst Biomed Engn Res, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Med & Biol Engn, 80 Daehak Ro, Daegu 41566, South Korea; Korea Inst Radiol & Med Sci, Korea Radioisotope Ctr Pharmaceut, Seoul 01812, South Korea; Korea Inst S&T Evaluat & Planning, Ctr Data Analyt Innovat, Off Natl R&D Evaluat & Anal, 1339 Wonjung Ro, Maengdong Myeon 27740, Eumseong Gun, South Korea; TARS Sci, Seoul 01662, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, 680 Guchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, 130 Dongdeok Ro, Daegu 41944, South Korea 58929528400; 57749644800; 57194601711; 57195807615; 58034650700; 57202928230; 57215273419; 56122945800; 25925922900; 7501840633 bksung@knu.ac.kr;dhwang@theranocure.com;baxun@naver.com;byang@theranocure.com;yunlee1903@knu.ac.com;jangwoo@kirams.re.kr;ejkim@kistep.re.kr;minsupkim.bio@gmail.com;leees82@naver.com;ychang@knu.ac.kr; ANTIOXIDANTS ANTIOXIDANTS-BASEL 2076-3921 13 2 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY 2024 6.6 10.4 0 2025-05-07 0 0 MRI; contrast agent; neuroinflammation; therapeutic; gallic acid; LPS; MD2; microglia OXIDATIVE STRESS; MEDIATED NEUROINFLAMMATION; MICROGLIA; ACTIVATION; PATHWAY contrast agent; gallic acid; LPS; MD2; microglia; MRI; neuroinflammation; therapeutic English 2024 2024-02 10.3390/antiox13020204 바로가기 바로가기 바로가기 바로가기
Article Hispidulin Alleviates Mast Cell-Mediated Allergic Airway Inflammation through FcεR1 and Nrf2/HO-1 Signaling Pathway Allergic asthma is a type 2 immune-response-mediated chronic respiratory disease. Mast cell activation influences the pathogenesis and exacerbation of allergic asthma. Therefore, the development of mast cell-targeting pharmacotherapy is important for managing allergic airway inflammation. We investigated the efficacy of hispidulin (HPD), natural flavone, in a mast-cell-mediated ovalbumin (OVA)-induced allergic airway inflammation model. HPD alleviated symptoms of allergic asthma and decreased the levels of immunoglobulin (Ig) E, type 2 inflammation, immune cell infiltration, and mast cell activation in the lung. Furthermore, in vivo analysis confirmed the efficacy of HPD through the evaluation of IgE-mediated allergic responses in a mast cell line. HPD treatment inhibited mast cell degranulation through inhibition of the Fc epsilon R1 signaling pathway and suppressed the expression of inflammatory cytokines (TNF-alpha, IL-4, IL-6, and IL-13) through suppression of the NF-kappa B signaling pathway. The antioxidant effects of HPD in activated mast cells were identified through modulation of antioxidant enzymes and the Nrf2/HO-1 signaling pathway. In conclusion, HPD may be a potential therapeutic candidate for allergic airway inflammation of asthma and acts by suppressing mast cell activation and oxidative stress. Jeong, Seungwon; Kim, Yeon-Yong; Lee, Dongwon; Kim, Sang-Hyun; Lee, Soyoung Korea Res Inst Biosci & Biotechnol KRIBB, Funct Biomat Res Ctr, 181 Ipsin Gil, Jeongeup 56212, South Korea; Jeonbuk Natl Univ, Dept Bionanotechnol & Bioconvergence Engn, 567 Baekje Daero, Jeonju 54896, South Korea; Jeonbuk Natl Univ, Dept Polymer Nano Sci & Technol, 567 Baekje Daero, Jeonju 54896, South Korea; Kyungpook Natl Univ, Cell Matrix Res Inst, Sch Med, Dept Pharmacol, Daegu 41944, South Korea ; Kim, Sang-Hyun/KQU-4555-2024 57219359192; 57190027396; 56189789200; 57210450420; 8537269200 jsw0212@kribb.re.kr;gyy123@kribb.re.kr;dlee@jbnu.ac.kr;shkim72@knu.ac.kr;sylee@kribb.re.kr; ANTIOXIDANTS ANTIOXIDANTS-BASEL 2076-3921 13 5 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY 2024 6.6 10.4 0.94 2025-05-07 2 2 hispidulin; allergic asthma; airway inflammation; mast cell; oxidative stress SUPEROXIDE-DISMUTASE ACTIVITY; OXIDATIVE STRESS; ASTHMA; DISEASES; INNATE; IGE airway inflammation; allergic asthma; hispidulin; mast cell; oxidative stress English 2024 2024-05 10.3390/antiox13050528 바로가기 바로가기 바로가기 바로가기
Article Improved weight initialization for deep and narrow feedforward neural network Appropriate weight initialization settings, along with the ReLU activation function, have become cornerstones of modern deep learning, enabling the training and deployment of highly effective and efficient neural network models across diverse areas of artificial intelligence. The problem of "dying ReLU,"where ReLU neurons become inactive and yield zero output, presents a significant challenge in the training of deep neural networks with ReLU activation function. Theoretical research and various methods have been introduced to address the problem. However, even with these methods and research, training remains challenging for extremely deep and narrow feedforward networks with ReLU activation function. In this paper, we propose a novel weight initialization method to address this issue. We establish several properties of our initial weight matrix and demonstrate how these properties enable the effective propagation of signal vectors. Through a series of experiments and comparisons with existing methods, we demonstrate the effectiveness of the novel initialization method. Lee, Hyunwoo; Kim, Yunho; Yang, Seung Yeop; Choi, Hayoung Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Ulsan Natl Inst Sci & Technol, Dept Math Sci, Ulsan 44919, South Korea; Kyungpook Natl Univ, KNU Inst Basic Sci, KNU LAMP Res Ctr, Daegu 41566, South Korea ; Choi, Hayoung/U-7046-2019; Kim, Yunho/F-4765-2014; Kim, Yunho/ITV-5368-2023 57209160180; 55699527100; 56589212300; 56942685000 lhw908@knu.ac.kr;yunhokim@unist.ac.kr;seungyeop.yang@knu.ac.kr;hayoung.choi@knu.ac.kr; NEURAL NETWORKS NEURAL NETWORKS 0893-6080 1879-2782 176 SCIE COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;NEUROSCIENCES 2024 6.3 10.4 0.35 2025-05-07 1 2 Weight initialization; Initial weight matrix; Deep learning; Feedforward neural networks; ReLU activation function APPROXIMATION; ERROR Deep learning; Feedforward neural networks; Initial weight matrix; ReLU activation function; Weight initialization Algorithms; Artificial Intelligence; Deep Learning; Humans; Neural Networks, Computer; Neurons; Backpropagation; Chemical activation; Deep neural networks; Neural network models; Activation functions; Deep learning; Initial weight matrix; Initial weights; Initialization methods; Neural network model; Property; ReLU activation function; Weight initialization; Weight matrices; accuracy; Article; artificial intelligence; controlled study; deep learning; deep neural network; feed forward neural network; initial weight matrix; machine learning; rectified linear unit; validation study; weight initialization; algorithm; artificial neural network; human; nerve cell; physiology; Feedforward neural networks English 2024 2024-08 10.1016/j.neunet.2024.106362 바로가기 바로가기 바로가기 바로가기
Editorial Material Laparoscopic Salvage Surgery for Infrarenal Para-aortic Lymph Node Recurrence of Rectal Cancer Na, Dong-Hee; Seo, An Na; Park, Soo Yeun Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Colorectal Canc Ctr, 807 Hogukro, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Colorectal Canc Ctr, Chilgok Hosp, 807 Hogukro, Daegu 41404, South Korea 57854200400; 55804153700; 40561578300 nadonghee@naver.com;san_0729@naver.com;psy-flower@daum.net; DISEASES OF THE COLON & RECTUM DIS COLON RECTUM 0012-3706 1530-0358 67 2 SCIE GASTROENTEROLOGY & HEPATOLOGY;SURGERY 2024 3.7 10.4 0.67 2025-05-07 1 1 Laparoscopy; Neoplasm metastasis; Para-aortic lymph node; Rectal neoplasm MANAGEMENT Laparoscopy; Neoplasm metastasis; Para-aortic lymph node; Rectal neoplasm Abdomen; Female; Humans; Laparoscopy; Lymph Node Excision; Lymph Nodes; Neoplasm Staging; Rectal Neoplasms; Retrospective Studies; Uterine Cervical Neoplasms; Article; blood salvage; cancer recurrence; human; infrarenal para aortic lymph node; laparoscopic surgery; lymph node dissection; mesocolon; paraaortic lymph node; rectum cancer; videorecording; abdomen; cancer staging; female; laparoscopy; lymph node; pathology; rectum tumor; retrospective study; uterine cervix tumor English 2024 2024-02 10.1097/dcr.0000000000003076 바로가기 바로가기 바로가기 바로가기
Article Long-term Complications of Laparoscopic or Robotic Lateral Pelvic Node Dissection After Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer BACKGROUND: Patients with rectal cancer who underwent lateral pelvic node dissection might be at a higher risk of postoperative complications derived from technical complexity. However, little is known regarding the long-term complications after lateral pelvic node dissection. OBJECTIVES: The study aimed to investigate the long-term complications of preoperative chemoradiotherapy, followed by total mesorectal excision with lateral pelvic node dissection for locally advanced rectal cancers. DESIGN: A retrospective analysis of a prospectively collected database. SETTINGS: This study was conducted in a tertiary cancer center. PATIENTS: Patients with rectal cancer who underwent total mesorectal excision with lateral pelvic node dissection after preoperative chemoradiotherapy between 2011 and 2019 were analyzed. All operations were performed via a laparoscopic or robotic approach. MAIN OUTCOME MEASURES: Long-term complications were defined as adverse events that persisted or newly appeared =90 days after surgery and could be related to the surgery. RESULTS: A total of 164 patients underwent total mesorectal excision with lateral pelvic node dissection after preoperative chemoradiotherapy. Short-term and long-term complication rates were 36.0% and 36.6%, respectively. Lymphocele was the most common long-term complication (17.7% of patients), and 11.6% had anastomotic leakage with chronic sinus. Of the patients with long-term complications, 20.7% of patients needed readmission for treatment. Of the 29 patients with lymphocele, 13 (41.0%) experienced spontaneous absorption and 11 (37.9%) required surgical or percutaneous catheter drainage or antibiotics use. Multivariate analysis showed pathologic pelvic node metastases (p = 0.008), and a higher number of unilateral harvested pelvic nodes (p = 0.001) were significantly associated with long-term complications. At the last follow-up (median duration of 43 months), 15.9% of patients had unresolved complications. LIMITATIONS: The retrospective design. CONCLUSIONS: Patients undergoing lateral pelvic node dissection experienced a higher frequency of long-term complications, but half of them had asymptomatic lymphoceles, most of which resolved spontaneously. However, further efforts should be paid to reduce anticipated complications related to lateral pelvic node dissection. See Video Abstract. Kim, Hye Jin; Choi, Gyu-Seog; Park, Jun Seok; Park, Soo Yeun; Song, Seung Ho; Lee, Sung Min; Jeong, Min Hye; Cho, Seung Hyun Kyungpook Natl Univ, Chilgok Hosp, Colorectal Canc Ctr, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Colorectal Canc Ctr, Chilgok Hosp, 807 Hogukro, Daegu 41404, South Korea Park, Joonhong/AAZ-9885-2020; Kim, Hye/W-1059-2019 57204567554; 8058759100; 35226761100; 40561578300; 57221771693; 55236751200; 57854899000; 55686242700 hjinkim@knu.ac.kr;kyuschoi@knu.ac.kr;psy-flower@daum.net;jojocrom@naver.com;rhsm3814@gmail.com;daring0102@hanmail.net;shcho2405@gmail.com; DISEASES OF THE COLON & RECTUM DIS COLON RECTUM 0012-3706 1530-0358 67 4 SCIE GASTROENTEROLOGY & HEPATOLOGY;SURGERY 2024 3.7 10.4 1.43 2025-05-07 3 4 Lateral pelvic lymph node; Lateral pelvic node dissection; Long-term complications; Lymphocele; Preoperative chemoradiotherapy TOTAL MESORECTAL EXCISION; CHRONIC PRESACRAL SINUS; LOW ANTERIOR RESECTION; ANASTOMOTIC LEAKAGE; RADIOTHERAPY; SURGERY; LYMPHADENECTOMY; DYSFUNCTION; LYMPHOCELES Chemoradiotherapy; Humans; Laparoscopy; Lymph Node Excision; Lymph Nodes; Lymphocele; Rectal Neoplasms; Retrospective Studies; Robotic Surgical Procedures; Treatment Outcome; alpha adrenergic receptor blocking agent; antibiotic agent; CA 19-9 antigen; carcinoembryonic antigen; fluorouracil; folinic acid; adult; advanced cancer; anastomosis leakage; cancer localization; cancer regression; cancer staging; catheter removal; chemoradiotherapy; chronic disease; chronic presacral sinus; chylous ascites; colonoscopy; Conference Paper; continuous infusion; conversion to open surgery; disease predisposition; female; fever; flank pain; gait disorder; hospital readmission; human; hydronephrosis; ileostomy; ischemia; laparoscopic surgery; leg edema; leg pain; length of stay; limb weakness; lymph node dissection; lymph node metastasis; lymphedema; lymphocele; major clinical study; male; middle aged; nerve injury; neurogenic bladder; nuclear magnetic resonance imaging; obturator nerve; operation duration; operative blood loss; paresthesia; pelvic pain; pelvis lymph node; percutaneous drainage; peroperative complication; physical examination; pneumonia; postoperative complication; postoperative edema; postoperative hemorrhage; postoperative ileus; postoperative pain; postoperative thrombosis; preoperative chemotherapy; preoperative radiotherapy; prevalence; radical resection; rectovaginal fistula; rectum abdominoperineal resection; rectum anterior resection; rectum cancer; retrospective study; risk factor; robot assisted surgery; seizure; stoma; surgical infection; surgical stapling; total mesorectal excision; treatment outcome; ureter fistula; ureter injury; ureter stricture; urine retention; vein thrombosis; wound infection; chemoradiotherapy; laparoscopy; lymph node; lymph node dissection; lymphocele; pathology; rectum tumor English 2024 2024-04 10.1097/dcr.0000000000003183 바로가기 바로가기 바로가기 바로가기
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WoS Web of Science. Clarivate Analytics에서 제공하는 학술 데이터베이스입니다. 해당 논문이 WoS에 수록되어 있는지 여부를 표시합니다 (○: 수록됨).
SCOPUS Elsevier에서 제공하는 세계 최대 규모의 초록 및 인용 데이터베이스입니다. 해당 논문이 SCOPUS에 수록되어 있는지 여부를 표시합니다 (○: 수록됨).
Document Type 문헌의 유형을 나타냅니다. Article(원저), Review(리뷰), Proceeding Paper(학회논문), Editorial Material(편집자료), Letter(레터) 등으로 분류됩니다.
Title 논문의 제목입니다.
Abstract 논문의 초록(요약)입니다. 연구의 목적, 방법, 결과, 결론을 간략히 요약한 내용입니다.
Authors 논문의 저자 목록입니다. 공동 저자가 여러 명인 경우 세미콜론(;)으로 구분됩니다.
Affiliation 저자들의 소속 기관 정보입니다. 대학, 연구소, 기업 등 저자가 소속된 기관명이 표시됩니다.
ResearcherID (WoS) Web of Science의 고유 연구자 식별번호입니다. 동명이인을 구분하고 연구자의 업적을 정확하게 추적할 수 있습니다.
AuthorsID (SCOPUS) SCOPUS의 고유 저자 식별번호입니다. 연구자의 모든 출판물을 추적하고 관리하는 데 사용됩니다.
Journal 논문이 게재된 학술지의 정식 명칭입니다.
JCR Abbreviation Journal Citation Reports에서 사용하는 저널의 공식 약어입니다. 저널을 간략하게 표기할 때 사용됩니다.
ISSN International Standard Serial Number. 국제표준연속간행물번호로, 인쇄본 저널에 부여되는 고유 식별번호입니다.
eISSN Electronic ISSN. 전자 버전 저널에 부여되는 고유 식별번호입니다.
Volume 저널의 권(Volume) 번호입니다. 보통 연도별로 하나의 권이 부여됩니다.
Issue 저널의 호(Issue) 번호입니다. 한 권 내에서 여러 호로 나누어 출판되는 경우가 많습니다.
WoS Edition Web of Science의 에디션입니다. SCIE(Science Citation Index Expanded), SSCI(Social Sciences Citation Index), AHCI(Arts & Humanities Citation Index) 등으로 구분됩니다.
WoS Category Web of Science의 주제 분류 카테고리입니다. 저널과 논문이 속한 학문 분야를 나타냅니다.
JCR Year 해당 저널의 JCR(Journal Citation Reports) 지표가 산출된 연도입니다.
IF (Impact Factor) 저널 영향력 지수. 최근 2년간 발표된 논문이 해당 연도에 평균적으로 인용된 횟수를 나타냅니다. 저널의 학술적 영향력을 나타내는 대표적인 지표입니다.
JCR (%) 해당 카테고리에서 저널이 위치하는 상위 백분율입니다. 값이 낮을수록 우수한 저널임을 의미합니다 (예: 5%는 상위 5%를 의미).
FWCI Field-Weighted Citation Impact. 분야별 가중 인용 영향력 지수입니다. 논문이 받은 인용을 동일 분야, 동일 연도, 동일 문헌 유형의 평균과 비교한 값입니다. 1.0이 평균이며, 1.0보다 높으면 평균 이상의 인용을 받았음을 의미합니다.
FWCI UpdateDate FWCI 값이 마지막으로 업데이트된 날짜입니다. FWCI는 인용이 누적됨에 따라 주기적으로 업데이트됩니다.
WOS Citation Web of Science에서 집계된 해당 논문의 총 인용 횟수입니다.
SCOPUS Citation SCOPUS에서 집계된 해당 논문의 총 인용 횟수입니다.
Keywords (WoS) 저자가 논문에서 직접 지정한 키워드입니다. Web of Science에 등록된 저자 키워드 목록입니다.
KeywordsPlus (WoS) Web of Science에서 자동으로 추출한 추가 키워드입니다. 논문의 참고문헌 제목에서 자주 등장하는 단어들로 생성됩니다.
Keywords (SCOPUS) 저자가 논문에서 직접 지정한 키워드입니다. SCOPUS에 등록된 저자 키워드 목록입니다.
KeywordsPlus (SCOPUS) SCOPUS에서 자동으로 추출하거나 추가한 색인 키워드입니다.
Language 논문이 작성된 언어입니다. 대부분 English이며, 그 외 다양한 언어로 작성된 논문이 포함될 수 있습니다.
Publication Year 논문이 출판된 연도입니다.
Publication Date 논문의 정확한 출판 날짜입니다 (년-월-일 형식).
DOI Digital Object Identifier. 디지털 객체 식별자로, 논문을 고유하게 식별하는 영구적인 식별번호입니다. 이를 통해 논문의 온라인 위치를 찾을 수 있습니다.