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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Parathyroidectomy for primary hyperparathyroidism: A retrospective analysis of localization, surgical characteristics, and treatment outcomes | Objective: To evaluate parathyroidectomy for primary hyperparathyroidism (PHPT) regarding localiza-tion, surgical characteristics, and treatment outcomes.Methods: Seventy-eight patients who underwent parathyroidectomy for PHPT were retrospectively reviewed. The results were analyzed according to intraoperative localization technique (IOLT), intra-operative parathyroid hormone (IOPTH) monitoring, and intraoperative nerve monitoring (IONM). The localization accuracy of ultrasonography (US), computed tomography (CT), and single-photon emission computed tomography (SPECT)-CT with sestamibi Tc99m was evaluated.Results: Parathyroidectomy was successfully completed in all 78 patients, achieving 100% surgical cure. For 60 patients with IOPTH monitoring, 10-min IOPTH decreased >50% from baseline in 57 (95.0%), and they achieved surgical cure. In the remaining three (5.0%) patients with 50% from baseline in two (3.3%) patients, achieving surgical cure without additional neck exploration. There were no differences in surgical cure and complications as a function of IOLT use or IOPTH monitoring. Operating time was significantly shorter with IOLT and IOPTH monitoring than without (IOLT: 70.9 min vs. 88.0 min, p = 0.013; IOPTH: 74.9 min vs. 91.9 min, p = 0.037). All 78 patients had adenoma including one patient with a double adenoma. Vocal cord paralysis was not observed in our series, regardless of IONM. US, CT, and SPECT-CT localized the pathological parathyroid gland accurately in 88.1%, 85.5%, and 86.8% of patients, respectively (p = 0.894).Conclusion: The surgical outcomes of parathyroidectomy for PHPT were excellent regardless of IOLT and IOPTH monitoring. However, these techniques can maximize the performance of parathyroid surgery by reducing operating time and rescuing challenging cases. (c) 2023 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/). | Ahn, Dongbin; Kwak, Ji Hye; Lee, Gil Joon | Kyungpook Natl Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Daegu, South Korea; Kyungpook Natl Univ, Dept Otolaryngol Head & Neck Surg, 130 Dongdeok Ro, Daegu 41944, South Korea | 44761055400; 57393330600; 57193082568; 55165818100 | godlikeu@naver.com; | ASIAN JOURNAL OF SURGERY | ASIAN J SURG | 1015-9584 | 0219-3108 | 46 | 2 | SCIE | SURGERY | 2023 | 3.5 | 10.4 | 0.33 | 2025-06-25 | 1 | 1 | Localization; Parathyroidectomy; parathyroid hormone; Primary hyperparathyroidism | METHYLENE-BLUE; MANAGEMENT; HORMONE; IDENTIFICATION; TRENDS | Localization; parathyroid hormone; Parathyroidectomy; Primary hyperparathyroidism | Adenoma; Humans; Hyperparathyroidism, Primary; Parathyroid Hormone; Parathyroidectomy; Retrospective Studies; Treatment Outcome; parathyroid hormone; adenoma; diagnostic imaging; human; parathyroidectomy; primary hyperparathyroidism; retrospective study; treatment outcome | English | 2023 | 2023-02 | 10.1016/j.asjsur.2022.07.032 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Preliminary outcomes of the LifeStream balloon-expandable stentgraft in Zenith Iliac branch device to preserve pelvic circulation: A Korean multicenter study | Background: To evaluate early outcomes of aortoiliac or isolated iliac artery aneurysm repair using the Zenith® Bifurcated Iliac Side (ZBIS) stent graft combined with the LifeStream™ Balloon Expandable Vascular Covered Stent as a bridging stentgraft. Methods: Between August 2018 and February 2020, 38 patients (37 male, mean age 72.7 years) received 46 LifeStream stents in conjunction with 38 ZBIS stent grafts to bridge hypogastric arteries for aneurysm repair in six university hospitals in Korea. The primary outcomes were technical success rate and procedure-related complications. Secondary outcomes were bridging stent graft patency and re-intervention. Results: All procedures were performed as elective standard endovascular aortic aneurysm repair (EVAR) and unilateral iliac branch device (IBD). Mean follow-up was 13.1 months, and patient overall survival rate was 96.7%. Technical success rate was 76.3% (n = 29). Causes of failure included seven total endoleaks; six type Ic and one type IIIc from the IBD junction, one unintentional IIA coverage, and one failure to deploy the IIA stent graft. Procedure-related complications occurred in two patients: one LifeStream migration and one ZBIS stent graft migration. Overall patency rates for the LifeStream and ZBIS stents were 97.4% and 97.2%, respectively. Conclusion: This multicenter preliminary experience with the LifeStream™ Balloon Expandable Vascular Covered Stent in IBD demonstrated good patency; however, an unexpectedly high rate of type Ic endoleaks was observed. Combined use of the LifeStream stent with the ZBIS stent graft is safe and feasible to preserve pelvic circulation with good patency and a low rate of device-related reintervention. © 2022 Asian Surgical Association and Taiwan Robotic Surgery Association | Yang, Shin-Seok; Kim, Hyung-Kee; Kim, Jang Yong; Lee, Taeseung; Lee, Sang Su; Park, Hyung Sub; Park, Sun Cheol; Park, Yang-Jin | Division of Vascular Surgery, Department of Surgery, Samsung Medical Center, Seoul, South Korea; Department of Surgery, Kyungpook National University School of Medicine, Daegu, South Korea; Division of Vascular and Transplant Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Division of Vascular Surgery, Department of Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea; Division of Vascular and EndoVascular Surgery, Department of Surgery, Pusan National University Yangsan Hospital, Yangsan, South Korea; Division of Vascular Surgery, Department of Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea; Division of Vascular and Transplant Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Division of Vascular Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea | 54400594300; 35169819900; 55963066600; 7501437724; 57192663025; 46161622600; 16638985800; 24367068100 | yjpark1974@gmail.com; | Asian Journal of Surgery | ASIAN J SURG | 1015-9584 | 0219-3108 | 46 | 1 | SCIE | SURGERY | 2023 | 3.5 | 10.4 | 0.65 | 2025-06-25 | 2 | Abdominal aortic aneurysm; Endoleak; Endovascular aneurysm repair; Iliac branch device | Aged; Aortic Aneurysm, Abdominal; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Endoleak; Endovascular Procedures; Humans; Male; Prosthesis Design; Republic of Korea; Retrospective Studies; Risk Factors; Stents; Treatment Outcome; abdominal aortic aneurysm; adverse device effect; aged; blood vessel prosthesis; blood vessel transplantation; clinical trial; endoleak; endovascular surgery; human; male; multicenter study; prosthesis design; retrospective study; risk factor; South Korea; stent; treatment outcome | English | Final | 2023 | 10.1016/j.asjsur.2022.01.012 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Salt Stress-Induced Modulation of Porphyrin Biosynthesis, Photoprotection, and Antioxidant Properties in Rice Plants (Oryza sativa) | Salt stress disrupts cellular ion homeostasis and adversely impacts plant growth and productivity. We examined the regulatory mechanisms of porphyrin biosynthesis, photoprotection, and antioxidant properties in salt-stressed rice seedlings. In response to 150 mM NaCl, the rice seedlings exhibited dehydration, reduced relative water content, and increased levels of conductivity, malondialdehyde, and H2O2. The expression levels of the salt-stress-responsive genes NHX1, SOS1, and MYB drastically increased after NaCl treatment. The seedlings grown under NaCl stress displayed declines in F-v/F-m, F-PSII, rETR(max), and photochemical quenching but increases in nonphotochemical quenching (NPQ) and the expression of genes involved in zeaxanthin formation, BCH, and VDE. Under salt stress conditions, levels of chlorophyll precursors significantly decreased compared to controls, matching the downregulation of CHLD, CHLH, CHLI, and PORB. By contrast, NaCl treatment led to increased heme content at 24 h of treatment and significant upregulations of FC2, HO1, and HO2 compared to controls. Salt-stressed seedlings also increased their expression of CATs (catalases) and APXs (ascorbate peroxidases) as well as the activities of superoxide dismutase, CAT, APX, and peroxidase. Our results indicate that chlorophyll and heme biosynthesis involve the protective strategies for salt stress alleviation through photoprotection by the scavenging of chlorophyll precursors and NPQ as well as activating antioxidant enzymes. | Nguyen, Anh Trung; Tran, Lien Hong; Jung, Sunyo | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea | 57215546250; 57193495407; 7403677383 | nguyenanh18190@knu.ac.kr;hong.tran@unimi.it;sjung@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 12 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2023 | 6 | 10.4 | 1.04 | 2025-06-25 | 6 | 7 | antioxidant enzymes; chlorophyll and heme biosynthesis; photoprotection; rice; salt stress | TETRAPYRROLE BIOSYNTHESIS; CHLOROPHYLL FLUORESCENCE; OXIDATIVE STRESS; HYDROGEN-PEROXIDE; XANTHOPHYLL CYCLE; SALINITY STRESS; GENE-EXPRESSION; BRASSICA-NAPUS; HEME; TOLERANCE | antioxidant enzymes; chlorophyll and heme biosynthesis; photoprotection; rice; salt stress | English | 2023 | 2023-08 | 10.3390/antiox12081618 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Structure-based discovery of pyrazolamides as novel ERR? inverse agonists | Estrogen-related receptor-gamma (ERR gamma) is an orphan nuclear receptor with high structural similarity to estrogen receptors (ER alpha and 8). The endogenous ligand of the receptor has yet to be identified. Only two classes of molecules-stilbene (diethylstilbestrol, 4-hydroxytamoxifen, and GSK5182) and flavonol (kaempferol) have been known to modulate the transcriptional activity of the receptor to date. Further, these agents lack selectivity to ERR gamma suggesting the need for a new inverse agonist. Thus, virtual screening was used to identify pyrazolamide 7 as a novel ERR gamma inverse agonist. Structure-based diversification and optimization of the compound further led to the identification of derivative 19 as a potent inverse agonist of ERR gamma with selectivity over other nuclear receptors including those of ERR family. Pyrazolamide 19 exhibits strong affinity towards ERR gamma and inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes, which suggests that these compounds may have antimicrobial, anti-coagulant and antidiabetic activities. | Yang, Su Hui; Khadka, Daulat Bikram; Han, Jinhe; Na, Soon-Young; Shin, Minsang; Kim, Don-Kyu; Oh, Byung-Chul; Kim, Eun Young; Choi, Hueng-Sik; Cho, Won-Jea | Chonnam Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Gwang Ju 61186, South Korea; Chonnam Natl Univ, Sch Biol Sci & Technol, Gwang Ju 61186, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, Deagu 41944, South Korea; Chonnam Natl Univ, Dept Integrat Food Biosci & Biotechnol, Gwang Ju 61186, South Korea; Gachon Univ, Grad Sch Med, Lee Gil Ya Canc & Diabet Inst, Incheon 21564, South Korea; Amer Univ Hlth Sci, Sch Pharm, Signal Hill, CA 90755 USA; Univ Michigan, Coll Pharm, Dept Med Chem, Ann Arbor, MI 48109 USA | Han, Jinhe/JGE-2504-2023; Kim, YoungHwan/B-2395-2013 | 35108397700; 35223460500; 57197767929; 7102024265; 7401536650; 37081358700; 59888976000; 57700667600; 7404338771; 7401774703 | hsc@jnu.ac.kr;wjcho@jnu.ac.kr; | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | EUR J MED CHEM | 0223-5234 | 1768-3254 | 250 | SCIE | CHEMISTRY, MEDICINAL | 2023 | 6 | 10.4 | 0.5 | 2025-06-25 | 3 | 3 | GAMMA; ACTIVATION; RECEPTORS; REGULATOR; BINDING; MEMBER; LIGAND | Diethylstilbestrol; Drug Inverse Agonism; Receptors, Estrogen; 1 phenyl n[3 (pyridin 3 yloxy) 5 (trifluoromethyl)phenyl] 3 (4 tolyl) 1h pyrazole 4 carboxamide; 1,3 diphenyl n[3 (pyridin 3 yloxy) 5 (trifluoromethyl)phenyl] 1h pyrazole 4 carboxamide; 3 (3 methoxyphenyl) 1 phenyl n[3 (pyridin 3 yloxy)phenyl] 1h pyrazole 4 carboxamide; 3 (3,4 dimethoxyphenyl)n[4 (2 methoxy 4 methylphenoxy)phenyl] 1 phenyl 1h pyrazole 4 carboxamide; 3 (3,4 dimethoxyphenyl)n[4 (4 isopropylphenoxy)phenyl) 1 phenyl 1h pyrazole 4 carboxamide; 3 (naphthalen 2 yl) 1 phenyl n[3 (pyridin 3 yloxy) 5 (trifluoromethyl)phenyl] 1h pyrazole 4 carboxamide; 3 [3 amino 5 (1,3 diphenyl 1h pyrazole 4 carboxamido)phenoxy]benzoic acid; 3 [3 amino 5 [1 phenyl 3 (4 tolyl) 1h pyrazole 4 carboxamido]phenoxy]benzoic acid; 4 [4 [[3 amino 5 (pyridin 3 yloxy)phenyl]carbamoyl] 3 phenyl 1h pyrazol 1 yl]benzoic acid; estrogen receptor; estrogen related receptor gamma; fibrinogen; hepcidin; methyl 4 [4 [[3 amino 5 (pyridin 3 yloxy)phenyl]carbamoyl] 3 phenyl 1h pyrazol]benzoate; methyl3 [3 amino 5 (3 diphenyl 1h pyrazole 4 carboxamido)phenoxy]benzoate; methyl3 [3 amino 5 [1 phenyl 3 (4 tolyl) 1h pyrazole 4 carboxamido]phenoxy]benzoate; methyl3 [3 amino 5 [3 (3 methoxyphenyl) 1 phenyl 1h pyrazole 4 carboxamido]phenox]benzoate; methyl3 [3 amino 5 [3 (naphthalen 2 yl) 1 phenyl 1h pyrazole 4 carboxamido]phenoxy]benzoate; methyl4 [3 amino 5 (1,3 diphenyl 1h pyrazole 4 carboxamido)phenoxy]benzoate; methyl4 [3 amino 5 [1 phenyl 3 (4 tolyl) 1h pyrazole 4 carboxamido]phenoxy]benzoate; n[3 (2 methoxy 4 methylphenoxy)phenyl] 1 phenyl 3 (4 tolyl) 1h pyrazole 4 carboxamide; n[3 (2 methoxy 4 methylphenoxy)phenyl] 1,3 diphenyl 1h pyrazole 4 carboxamide; n[3 (2 methoxy 4 methylphenoxy)phenyl] 3 (3 methoxyphenyl) 1 phenyl 1h pyrazole 4 carboxamide; n[3 acetamido 5 (pyridin 3 yloxy)phenyl] 1,3 diphenyl 1h pyrazole 4 carboxamide; n[3 amino 5 (3 isopropylphenoxy)phenyl] 1 phenyl 3 (4 tolyl) 1h pyrazole 4 carboxamide; n[3 amino 5 (3 isopropylphenoxy)phenyl] 1,3 diphenyl 1h pyrazole 4 carboxamide; n[3 amino 5 (3 methoxyphenoxy)phenyl] 1 phenyl 3 (4 tolyl) 1h pyrazole 4 carboxamide; n[3 amino 5 (3 methoxyphenoxy)phenyl] 1,3 diphenyl 1h pyrazole 4 carboxamide; n[3 amino 5 (3 methoxyphenoxy)phenyl] 3 (3 methoxyphenyl) 1 phenyl 1h pyrazole 4 carboxamide; n[3 amino 5 (pyridin 3 yloxy)phenyl] 1 phenyl 3 (4 tolyl) 1h pyrazole 4 carboxamide; n[3 amino 5 (pyridin 3 yloxy)phenyl] 1 [4 (diethylcarbamoyl)phenyl] 3 phenyl 1h pyrazole 4 carboxamide; n[3 amino 5 (pyridin 3 yloxy)phenyl] 1 [4 (hydroxymethyl)phenyl] 3 phenyl 1h pyrazole 4 carboxamide; n[3 amino 5 (pyridin 3 yloxy)phenyl] 1,3 diphenyl 1h pyrazole 4 carboxamide; n[3 amino 5 (pyridin 3 yloxy)phenyl] 3 (3 methoxyphenyl) 1 phenyl 1h pyrazole 4 carboxamide; n[3 amino 5 (pyridin 3 yloxy)phenyl] 3 (naphthalen 2 yl) 1 phenyl 1h pyrazole 4 carboxamide; n[3 amino 5 [2 (dimethylamino)ethoxy]phenyl] 3 (3 methoxyphenyl) 1 phenyl 1h pyrazole 4 carboxamide; n[3 amino 5 [3 (dimethylamino)propoxy]phenyl] 1,3 diphenyl 1h pyrazole 4 carboxamide; n[3 amino 5 [3 (dimethylamino)propoxy]phenyl] 3 (3 methoxyphenyl) 1 phenyl 1h pyrazole 4 carboxmide; n[3 [2 (dimethylamino)ethoxy] 5 (trifluoromethyl)phenyl] 1,3 diphenyl 1h pyrazole 4 carboxamide; n[3 [2 (dimethylamino)ethoxy] 5 (trifluoromethyl)phenyl] 3 (3 methoxyphenyl) 1 phenyl 1h pyrazole 4 carboxamide; n[3 [3 (dimethylamino)propoxy] 5 (trifluoromethyl)phenyl] 1,3 diphenyl 1h pyrazole 4 carboxamide; n[3 [3 (dimethylamino)propoxy] 5 (trifluoromethyl)phenyl] 3 (3 methoxyphenyl) 1 phenyl 1h pyrazole 4 carboxamide; n[4 (2 methoxy 4 methylphenoxy)phenyl] 1 phenyl 3 (4 tolyl) 1h pyrazole 4 carboxamide; n[4 (2 methoxy 4 methylphenoxy)phenyl] 1,3 diphenyl 1h pyrazole 4 carboxamide; n[4 (4 isopropylphenoxy)phenyl] 1 phenyl 3 (4 tolyl) 1h pyrazole 4 carboxamide; sodium 4 [4 [[3 amino 5 (pyridin 3 yloxy)phenyl]carbamoyl] 3 phenyl 1h pyrazol 1 yl]benzoate; steroid hormone receptor stimulating agent; unclassified drug; diethylstilbestrol; estrogen receptor; anticoagulation; antidiabetic activity; antimicrobial activity; Article; binding affinity; controlled study; drug identification; drug potency; drug receptor binding; drug screening; drug synthesis; gene expression; gluconeogenesis; inverse agonism; metabolism | English | 2023 | 2023-03-15 | 10.1016/j.ejmech.2023.115174 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | The Key Roles of ROS and RNS as a Signaling Molecule in Plant-Microbe Interactions | Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a pivotal role in the dynamic cell signaling systems in plants, even under biotic and abiotic stress conditions. Over the past two decades, various studies have endorsed the notion that these molecules can act as intracellular and intercellular signaling molecules at a very low concentration to control plant growth and development, symbiotic association, and defense mechanisms in response to biotic and abiotic stress conditions. However, the upsurge of ROS and RNS under stressful conditions can lead to cell damage, retarded growth, and delayed development of plants. As signaling molecules, ROS and RNS have gained great attention from plant scientists and have been studied under different developmental stages of plants. However, the role of RNS and RNS signaling in plant-microbe interactions is still unknown. Different organelles of plant cells contain the enzymes necessary for the formation of ROS and RNS as well as their scavengers, and the spatial and temporal positions of these enzymes determine the signaling pathways. In the present review, we aimed to report the production of ROS and RNS, their role as signaling molecules during plant-microbe interactions, and the antioxidant system as a balancing system in the synthesis and elimination of these species. | Khan, Murtaza; Ali, Sajid; Al Azzawi, Tiba Nazar Ibrahim; Saqib, Saddam; Ullah, Fazal; Ayaz, Asma; Zaman, Wajid | Yeungnam Univ, Dept Hort & Life Sci, Gyongsan 38541, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China; Univ Chinese Acad Sci, Beijing 100049, Peoples R China; Lanzhou Univ, Sch Life Sci, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China; Hubei Univ, Sch Life Sci, State Key Lab Biocatalysis & Enzyme Engn, Wuhan 430062, Peoples R China; Yeungnam Univ, Dept Life Sci, Gyongsan 38541, South Korea | Ayaz, Asma/AAR-1766-2020; Zaman, Wajid/J-6491-2019; Saqib, Saddam/AAP-1486-2020; Ullah, Fazal/J-7305-2019; Ali, Sajid/GLS-7322-2022 | 57207990116; 57214290889; 57224980187; 57205153361; 57204462519; 57203092667; 57193825110 | wajidzaman@yu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 12 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2023 | 6 | 10.4 | 6.91 | 2025-06-25 | 104 | 113 | ROS; RNS; signaling; plant-microbe interactions; antioxidant system | S-NITROSOGLUTATHIONE REDUCTASE; PROGRAMMED CELL-DEATH; COMPLETE PENETRATION RESISTANCE; NITRIC-OXIDE PRODUCTION; REACTIVE OXYGEN; HYDROGEN-PEROXIDE; ARABIDOPSIS-THALIANA; NITRATE REDUCTASE; HYPERSENSITIVE RESPONSE; OXIDATIVE DAMAGE | antioxidant system; plant–microbe interactions; RNS; ROS; signaling | English | 2023 | 2023-02 | 10.3390/antiox12020268 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Unraveling the Antioxidant Capacity of Spatholobi caulis in Nonalcoholic Fatty Liver Disease: A Multiscale Network Approach Integrated with Experimental Validation | Nonalcoholic fatty liver disease (NAFLD) is a global health problem that is closely associated with obesity and metabolic syndrome. Spatholobi caulis (SC) is a herbal medicine with potential hepatoprotective effects; however, its active compounds and underlying mechanisms have not been fully explored. In this study, we combined a multiscale network-level approach with experimental validation to investigate SC's antioxidant properties and their impact on NAFLD. Data collection and network construction were performed, and active compounds and key mechanisms were identified through multi-scale network analysis. Validation was conducted using in vitro steatotic hepatocyte models and in vivo high-fat diet-induced NAFLD models. Our findings revealed that SC treatment improved NAFLD by modulating multiple proteins and signaling pathways, including AMPK signaling pathways. Subsequent experiments showed that SC treatment reduced lipid accumulation and oxidative stress. We also validated SC's effects on AMPK and its crosstalk pathways, emphasizing their role in hepatoprotection. We predicted procyanidin B2 to be an active compound of SC and validated it using a lipogenesis in vitro model. Histological and biochemical analyses confirmed that SC ameliorated liver steatosis and inflammation in mice. This study presents SC's potential use in NAFLD treatment and introduces a novel approach for identifying and validating active compounds in herbal medicine. | Bae, Su-Jin; Lee, Won-Yung; Bak, Seon-Been; Kim, Young-Eun; Kim, Min-Jin; Kim, Young-Woo | Dongguk Univ, Sch Korean Med, Gyeonju 38066, South Korea; Kyungpook Natl Univ, Dept Comp Sci & Engn, Daegu 41566, South Korea | ; Kim, Tackeun/N-8436-2019 | 57437662600; 57207303603; 57455566300; 58295853000; 57231551400; 55699527800 | realsujin@dgu.ac.kr;wonyung21@dongguk.ac.kr;sbpark@dongguk.ac.kr;yekim@dgu.ac.kr;mjkim@dgu.ac.kr;ywk@dongguk.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 12 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2023 | 6 | 10.4 | 0.45 | 2025-06-25 | 3 | 3 | oxidative stress; non-alcoholic fatty liver diseases; Spatholobi caulis; multiscale network | PROCYANIDIN B2 PROTECTS; NADPH OXIDASES; YAP; PHARMACOLOGY; MODULATION; MECHANISMS; APOPTOSIS; INJURY; AMPK | multiscale network; non-alcoholic fatty liver diseases; oxidative stress; Spatholobi caulis | English | 2023 | 2023-05-13 | 10.3390/antiox12051097 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Adversarial Lagrangian integrated contrastive embedding for limited size datasets | Certain datasets contain a limited number of samples with highly various styles and complex structures. This study presents a novel adversarial Lagrangian integrated contrastive embedding (ALICE) method for small-sized datasets. First, the accuracy improvement and training convergence of the proposed pre-trained adversarial transfer are shown on various subsets of datasets with few samples. Second, a novel adversarial integrated contrastive model using various augmentation techniques is investigated. The proposed structure considers the input samples with different appearances and gen-erates a superior representation with adversarial transfer contrastive training. Finally, multi-objective augmented Lagrangian multipliers encourage the low-rank and sparsity of the presented adversarial contrastive embedding to adaptively estimate the coefficients of the regularizers automatically to the optimum weights. The sparsity constraint suppresses less representative elements in the feature space. The low-rank constraint eliminates trivial and redundant components and enables superior generalization. The performance of the proposed model is verified by conducting ablation studies by using benchmark datasets for scenarios with small data samples.(c) 2022 Elsevier Ltd. All rights reserved. | Jalali, Amin; Lee, Minho | Kyungpook Natl Univ, AI Inst Technol, KNU LG Elect Convergence Res Ctr, Daegu 41566, South Korea; Kyungpook Natl Univ, Grad Sch Artificial Intelligence, Daegu 41566, South Korea | Lee, Min-Ho/ABE-5735-2021; Jalali, Amin/AAH-6921-2019 | 57022190400; 57191730119 | max.jalali@gmail.com;mholee@gmail.com; | NEURAL NETWORKS | NEURAL NETWORKS | 0893-6080 | 1879-2782 | 160 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;NEUROSCIENCES | 2023 | 6 | 10.5 | 0.95 | 2025-06-25 | 8 | 8 | Deep learning; Adversarial transfer contrastive embedding; Small and limited datasets; Sparsity and low -rank constraints; Augmented Lagrangian multipliers | RECOGNITION; ATTENTION; NETWORK | Adversarial transfer contrastive embedding; Augmented Lagrangian multipliers; Deep learning; Small and limited datasets; Sparsity and low-rank constraints | Benchmarking; Generalization, Psychological; Benchmarking; Constrained optimization; Deep learning; Lagrange multipliers; Adversarial transfer contrastive embedding; Augmented lagrangian multiplier; Augmented Lagrangians; Deep learning; Embeddings; Lagrangian; Lagrangian multipliers; Rank constraints; Small and limited dataset; Sparsity and low-rank constraint; article; deep learning; embedding; benchmarking; Embeddings | English | 2023 | 2023-03 | 10.1016/j.neunet.2022.12.023 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | CT-Loc: Cross-domain visual localization with a channel-wise transformer | We tackle the cross-domain visual localization problem of estimating camera position and orientation from real images without three-dimensional (3D) spatial mapping or modeling. Recent studies have shown suboptimal performance in this task owing to the photometric and geometric differences between synthetic and real images. In this study, we present a deep learning approach that uses a channel-wise transformer localization (CT-Loc) framework. Inspired by the human behavior of looking for structural landmarks to estimate one's location, CT-Loc encodes the most salient features of task -relevant objects in target scenes. To evaluate the efficacy of the proposed method in a real-world application, we built a complex and large-scale dataset of the interior of the mechanical room during operations and conducted extensive performance comparisons with the publicly available state-of-the-art University of Melbourne Corridor and Virtual KITTI 2 datasets. Compared with the otherwise best-performing BIM-PoseNet indoor camera localization model, our method significantly reduces position and orientation errors through the application of attention weights and saliency maps while also learning only the visual structural patterns (e.g., floors and doors) that are most relevant to localization tasks. Our model successfully ignores uninformative objects. This approach yields higher -level robust camera-pose regression localization results without requiring prebuilt maps. The code is available at https://github.com/kdaeho27/CT-Loc.(c) 2022 Elsevier Ltd. All rights reserved. | Kim, Daeho; Kim, Jaeil | Kyungpook Natl Univ, Dept Artificial Intelligence, 80 Daehak Ro, Daegu, South Korea; Kyungpook Natl Univ, Sch Comp Sci & Engn, 80 Daehak Ro, Daegu, South Korea | ; Kim, Dae-ho/AAY-7919-2020 | 57216887648; 57211615348 | kdaeho27@gmail.com;threeyears@gmail.com; | NEURAL NETWORKS | NEURAL NETWORKS | 0893-6080 | 1879-2782 | 158 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;NEUROSCIENCES | 2023 | 6 | 10.5 | 1.18 | 2025-06-25 | 11 | 10 | Visual localization; Cross-domain; 3D model; Transformer; Deep learning | INFORMATION MODELING BIM | 3D model; Cross-domain; Deep learning; Transformer; Visual localization | Humans; Tomography, X-Ray Computed; 3D modeling; Behavioral research; Computerized tomography; Deep learning; Indoor positioning systems; Large dataset; Learning systems; 3D models; 3d-modeling; Camera orientation; Cross-domain; Deep learning; Localisation; Localization problems; Real images; Transformer; Visual localization; Article; artificial neural network; computer model; conceptual framework; deep learning; image analysis; image retrieval; mathematical computing; photometry; three-dimensional imaging; human; x-ray computed tomography; Cameras | English | 2023 | 2023-01 | 10.1016/j.neunet.2022.11.014 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Diagnostic performance of synthetic relaxometry for predicting neurodevelopmental outcomes in premature infants: a feasibility study | ObjectivesTo investigate the predictability of synthetic relaxometry for neurodevelopmental outcomes in premature infants and to evaluate whether a combination of relaxation times with clinical variables or qualitative MRI abnormalities improves the predictive performance.MethodsThis retrospective study included 33 premature infants scanned with synthetic MRI near or at term equivalent age. Based on neurodevelopmental assessments at 18-24 months of corrected age, infants were classified into two groups (no/mild disability [n = 23] vs. moderate/severe disability [n = 10]). Clinical and MRI characteristics associated with moderate/severe disability were explored, and combined models incorporating independent predictors were established. Ultimately, the predictability of relaxation times, clinical variables, MRI findings, and a combination of the two were evaluated and compared. The models were internally validated using bootstrap resampling.ResultsProlonged T1-frontal/parietal and T2-parietal periventricular white matter (PVWM), moderate-to-severe white matter abnormality, and bronchopulmonary dysplasia were significantly associated with moderate/severe disability. The overall predictive performance of each T1-frontal/-parietal PVWM model was comparable to that of individual MRI finding and clinical models (AUC = 0.71 and 0.76 vs. 0.73 vs. 0.83, respectively; p > 0.27). The combination of clinical variables and T1-parietal PVWM achieved an AUC of 0.94, sensitivity of 90%, and specificity of 91.3%, outperforming the clinical model alone (p = 0.049). The combination of MRI finding and T1-frontal PVWM yielded AUC of 0.86, marginally outperforming the MRI finding model (p = 0.09). Bootstrap resampling showed that the models were valid.ConclusionsIt is feasible to predict adverse outcomes in premature infants by using early synthetic relaxometry. Combining relaxation time with clinical variables or MRI finding improved prediction. | Kim, Ji Sook; Cho, Hyun-Hae; Shin, Ji-Yeon; Park, Sook-Hyun; Min, Yu-Sun; Park, Byunggeon; Hong, Jihoon; Park, Seo Young; Hahm, Myong-Hun; Hwang, Moon Jung; Lee, So Mi | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pediat, 807 Hoguk Ro, Daegu 41404, South Korea; Ewha Womans Univ, Seoul Hosp, Dept Radiol, 260 Gonghang Daero, Seoul 07804, South Korea; Ewha Womans Univ, Seoul Hosp, Med Res Inst, Coll Med, 260 Gonghang Daero, Seoul 07804, South Korea; Kyungpook Natl Univ, Sch Med, Dept Prevent Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Yonsei Univ, Coll Med, Dept Pediat, Seoul 06273, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Rehabil Med, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Radiol, 807 Hoguk Ro, Daegu 41404, South Korea; Gen Elect GE Healthcare Korea, 416 Hangsng Daero, Seoul 04637, South Korea | 57194705685; 56544900900; 55567961600; 57194595004; 48061349800; 57211532915; 57215858314; 57210379391; 56015548700; 57200114449; 56824903400 | amour7230@knu.ac.kr; | EUROPEAN RADIOLOGY | EUR RADIOL | 0938-7994 | 1432-1084 | 33 | 10 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2023 | 4.7 | 10.5 | 1.08 | 2025-06-25 | 5 | 5 | Brain; Magnetic resonance imaging; Premature birth; Neurodevelopmental disorders; Synthetic magnetic resonance imaging | LOW-BIRTH-WEIGHT; EXTREMELY PRETERM INFANTS; ACTIVE PERINATAL-CARE; CEREBRAL-BLOOD-FLOW; WHITE-MATTER; RELAXATION-TIMES; BRAIN MATURATION; DIFFUSION TENSOR; MRI; INJURY | Brain; Magnetic resonance imaging; Neurodevelopmental disorders; Premature birth; Synthetic magnetic resonance imaging | Brain; Feasibility Studies; Humans; Infant; Infant, Newborn; Infant, Premature; Magnetic Resonance Imaging; Retrospective Studies; adverse outcome; Article; clinical article; clinical significance; controlled study; diagnostic test accuracy study; diagnostic value; female; human; lung dysplasia; male; mental disease; newborn period; nuclear magnetic resonance imaging; prematurity; retrospective study; sensitivity and specificity; brain; diagnostic imaging; feasibility study; infant; newborn; nuclear magnetic resonance imaging | English | 2023 | 2023-10 | 10.1007/s00330-023-09881-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Disturbance rejection for multi-weighted complex dynamical networks with actuator saturation and deception attacks via hybrid-triggered mechanism | In this work, we address hybrid-driven-based robust synchronization problem for multi-weighted com-plex dynamical networks with actuator saturation and deception attacks. The hybrid-triggered mecha-nism, which combines a switch between the event-triggered scheme and the time-triggered scheme, is often used to reduce the data transmission and the alleviate network burden. Further, the equivalent -input-disturbance technique is applied to eliminate the unknown disturbance effect of the addressed system. Moreover, a memory controller is designed under actuator saturation to ensure that the resultant augmented system is asymptotically synchronized even in the presence of deception attacks. Finally, three numerical examples are given to show the validity of the obtained theoretical results.(c) 2023 Elsevier Ltd. All rights reserved. | Sakthivel, R.; Kwon, O. M.; Park, M. J.; Lee, S. M. | Chungbuk Natl Univ, Sch Elect Engn, Cheongju 28644, South Korea; Kyung Hee Univ, Ctr Global Converging Humanities, 1732 Deogyeong Daero, Yongin 17104, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daehak Ro 80, Daegu, South Korea; Bharathiar Univ, Dept Appl Math, Coimbatore 641046, India; Sungkyunkwan Univ, Dept Math, Suwon 440746, South Korea | ; Ramalingam, Sakthivel/ABD-8807-2021; Lee, Sangmoon/C-4502-2018; Kwon, O.M./AAB-4260-2019 | 6701666350; 55444931800; 35070283100; 59510733500 | krsakthivel0209@gmail.com;madwind@chungbuk.ac.kr; | NEURAL NETWORKS | NEURAL NETWORKS | 0893-6080 | 1879-2782 | 162 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;NEUROSCIENCES | 2023 | 6 | 10.5 | 1.42 | 2025-06-25 | 9 | 12 | Complex dynamical networks; Equivalent-input-disturbance; Multi-weights; Actuator saturation; Deception attacks | TIME-VARYING DELAY; SWITCHED SYSTEMS; FINITE-TIME; SYNCHRONIZATION; SUBJECT; DESIGN; MEMORY; COMMUNICATION | Actuator saturation; Complex dynamical networks; Deception attacks; Equivalent-input-disturbance; Multi-weights | Physical Phenomena; Actuators; Complex networks; Actuator saturations; Complex dynamical networks; Deception attack; Equivalent-input-disturbance; Event-triggered; Hybrid-driven; Input disturbance; Multi-weight; Robust synchronization; Synchronization problem; article; deception; memory; validity; physical phenomena; Disturbance rejection | English | 2023 | 2023-05 | 10.1016/j.neunet.2023.02.031 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Real-time noise-free inline self-interference incoherent digital holography with temporal geometric phase multiplexing | In this paper, we propose a real-time incoherent digital holographic (IDH) recording system free from bias and twin-image noises. A motionless three-step polarization-encoded phase-shifter operating at 99 Hz is realized with two electrically controllable birefringence-mode liquid crystal cells operating in tandem with a geometric phase lens and polarizers. Based on the proposed optical configuration, a coaxial straight-line self-interference IDH recording system is devised. Notably, the elimination of bias and twin-image noise from three phase-shifted images is demonstrated as a proof of concept. Moreover, complex-valued holographic video acquisitions with a resolution greater than 20 megapixels are demonstrated, with an effective acquisition frequency of 33 Hz. & COPY; 2023 Chinese Laser Press | Choi, Kihong; Lee, Jae-Won; Shin, Jungyeop; Hong, Keehoon; Park, Joongki; Kim, Hak-Rin | Elect & Telecommun Res Inst, Digital Holog Res Sect, Daejeon 34129, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | ; Kim, Hak-Rin/T-1897-2019 | 56706731400; 58377059800; 57956975700; 26326352800; 34868474500; 7410124944 | rineey@knu.ac.kr; | PHOTONICS RESEARCH | PHOTONICS RES | 2327-9125 | 11 | 6 | SCIE | OPTICS | 2023 | 6.6 | 10.5 | 2.82 | 2025-06-25 | 21 | 20 | DIFFRACTION; FINCH; LENS | Image recording; Liquid crystals; Digital holography; Geometric phase; Holographic recordings; Image noise; Liquid crystal cells; Phase-shifters; Real- time; Recording systems; Self-interferences; Twin-image; Holography | English | 2023 | 2023-06-01 | 10.1364/prj.476354 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Shape-tailored whispering gallery microcavity lasers designed by transformation optics | Semiconductor microdisk lasers have great potential as low-threshold, high-speed, and small-form-factor light sources required for photonic integrated circuits because of their high -Q factors associated with long-lived whispering gallery modes (WGMs). Despite these advantages, the rotational symmetry of the disk shape restricts practical applications of the photonic devices because of their isotropic emission, which lacks directionality in far-field emission and difficulty in free-space out coupling. To overcome this problem, deformation of the disk cavity has been mainly attempted. However, the approach cannot avoid significant Q degradation owing to the broken rotational symmetry. Here, we first report a deformed shape microcavity laser based on transformation optics, which exploits WGMs free from Q degradation. The deformed cavity laser was realized by a spatially varying distribution of deep-sub-wavelength-scale (60 nm diameter) nanoholes in an InGaAsP-based multi-quantum-well heterostructure. The lasing threshold of our laser is one-third of that of the same shaped homogeneous laser and quite similar to that of a homogeneous microdisk laser. The results mean that Q spoiling caused by the boundary shape deformation is recovered by spatially varying nanohole density distribution designed by transformation optics and effective medium approximation. (c) 2023 Chinese Laser Press | Lee, Yong-Hoon; Park, Honghwi; Kim, Inbo; Park, Sang-Jun; Rim, Sunghwan; Park, Byoung Jun; Kim, Moohyuk; Kim, Yushin; Kim, Myung-Ki; Han, Won Seok; Kim, Hosung; Park, Hongsik; Choi, Muhan | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Elect & Telecommun Res Inst ETRI, Photon Wireless Devices Res Div, Daejeon 34129, South Korea; Kyungpook Natl Univ, Digital Technol Res Ctr, Daegu 41566, South Korea; Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 02841, South Korea | Kim, Myung-Ki/JXO-0303-2024; Park, Byoung Jun/KLD-5818-2024; Park, Honghwi/KIC-1871-2024 | 57219622064; 57206811785; 56278391800; 58969718200; 7005692465; 59091023400; 57219327562; 57196173536; 35088305600; 7401900032; 57188693390; 35366976200; 7402093793 | hpark@ee.knu.ac.kr;mhchoi@ee.knu.ac.kr; | PHOTONICS RESEARCH | PHOTONICS RES | 2327-9125 | 11 | 9 | SCIE | OPTICS | 2023 | 6.6 | 10.5 | 1.27 | 2025-06-25 | 10 | 9 | DIRECTIONAL EMISSION | III-V semiconductors; Microcavities; Optical resonators; Photonic devices; Q factor measurement; Quantum well lasers; Semiconductor quantum wells; High Speed; Low thresholds; Microcavity laser; Nanoholes; Photonics Integrated Circuits; Rotational symmetries; Semiconductor microdisk lasers; Small form factors; Transformation optics; Whispering-gallery microcavities; Whispering gallery modes | English | 2023 | 2023-09-01 | 10.1364/prj.496471 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Biochar application: A sustainable approach to improve soil health | Soil is a fundamental part of successful agriculture, and its quality has to be improved to maximize crop yield and soil fertility. To increase crop productivity and soil fertility, biochar can be applied to the soil. Biochar is a solid carbon-rich product produced from biomass of agricultural crop residues, wastes, and wood, through pyrolysis in an oxygen-deficient condition. Carbon sequestration through biochar is important because of its potential ap-plications in recycling wastes, retaining nutrients in the soil and lowering greenhouse gas emissions. In this review, we explore the various applications of biochar to ensure the safe and sustainable improvement of soil fertility. This review provides an overview of biochar properties, production technology, and its employment in the agriculture. This review would be a useful resource for researchers, farmers, and academics who are inter-ested in the utilization of biochar. | Yadav, Shubh Pravat Singh; Bhandari, Sujan; Bhatta, Dibya; Poudel, Anju; Bhattarai, Susmita; Yadav, Puja; Ghimire, Netra; Paudel, Prava; Paudel, Pragya; Shrestha, Jiban; Oli, Biplov | Purbanchal Univ, GP Koirala Coll Agr & Res Ctr, Gothgaun, Morang, Nepal; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Tennessee State Univ, Otis L Floyd Nursery Res Ctr, Dept Agr & Environm Sci, 472 Cadillac Lane, Mcminnville, TN 37110 USA; Natl Plant Breeding & Genet Res Ctr, Nepal Agr Res Council, Khumaltar, Lalitpur, Nepal; Agr & Forestry Univ, Coll Nat Resource Management, Bardibas, Nepal | ; Yadav, Shubh Pravat/GNH-2091-2022; Yadav, Puja/AAV-2179-2020; Shrestha, Jiban/AAD-1778-2020; Poudel, Anju/HLG-3959-2023 | 57984455200; 58059925600; 57450591300; 58059925700; 58405863900; 58059403400; 57209659637; 58059841800; 58059753700; 57221769055; 58059753800 | sushantpy8500@gmail.com;bhandarisujan098@gmail.com;divine@knu.ac.kr;anjupoudel65@gmail.com;susmeetabhattrai80@gmail.com;ypuja702@gmail.com;netraghimire779@gmail.com;paudelprava6@gmail.com;paudelpragya58@gmail.com;jibshrestha@gmail.com;biplovoli@afu.edu.np; | JOURNAL OF AGRICULTURE AND FOOD RESEARCH | J AGR FOOD RES | 2666-1543 | 11 | ESCI | AGRICULTURE, MULTIDISCIPLINARY;FOOD SCIENCE & TECHNOLOGY | 2023 | 4.8 | 10.7 | 9.14 | 2025-06-25 | 109 | 133 | Biochar; Soil fertility; Biomass; Crop production | PHYSICOCHEMICAL PROPERTIES; CHARCOAL; WASTE; CHALLENGES; HYDROCHAR; PYROLYSIS; RESIDUES; BENEFITS; FUTURE; RISKS | Biochar; Biomass; Crop production; Soil fertility | English | 2023 | 2023-03 | 10.1016/j.jafr.2023.100498 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Investigation of phenyllactic acid as a potent tyrosinase inhibitor produced by probiotics | Melanogenesis is responsible for skin pigmentation and the enzymatic browning of foods. Tyrosinases play a major role in melanin synthesis, and many attempts have been made to identify new natural tyrosinase inhibitors, but few have sought to do in microbes. Postbiotics are bioactive compounds produced by the metabolism of probiotics and have been reported to be safe and effective. In this study, we evaluated the tyrosinase inhibitory effects of culture supernatants of probiotics and discovered novel bacterial metabolites that can be used as a potent tyrosinase inhibitor based on metabolomics. Cultures of Bifidobacterium bifidum IDCC 4201 and Lactiplantibacillus plantarum IDCC 3501 showed effective anti-tyrosinase, reduced melanin synthesis, and altered protein expression associated with the melano-genesis pathway. Comparative metabolomics analyses conducted by GC-MS identified metabolites commonly produced by B. bifidum and L. plantarum. Of eight selected metabolites, phenyllactic acid exhibited significant tyrosinase-inhibitory activity. Our findings suggest that applications of probiotic culture supernatants containing high amounts of phenyllactic acid have potential use as anti-melanogenesis agents in food and medicines. | Shin, Minhye; Truong, Van-Long; Lee, Minjee; Kim, Donggyu; Kim, Myun Soo; Cho, Hana; Jung, Young Hoon; Yang, Jungwoo; Jeong, Woo Sik; Kim, Younghoon | Inha Univ, Coll Med, Dept Microbiol, Incheon 22212, South Korea; Inha Univ, Dept Biomed Sci, Program Biomed Sci & Engn, Incheon 22212, South Korea; Kyungpook Natl Univ, Food & Bioind Res Inst, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea; ICBIO, Cheonan Si 31027, Chungchengnam D, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Dept Agr Biotechnol, Seoul 08826, South Korea | Jeong, Woo-Sik/AAN-6885-2020; Jung, Young/F-1703-2013; Jung, Young Hoon/F-1703-2013 | 57208401604; 55925363400; 57221979843; 58032283400; 57225050979; 59643255300; 55550063700; 56076383700; 10440750200; 57861979600 | yjw@ildong.com;wsjeong@knu.ac.kr;ykeys2584@snu.ac.kr; | CURRENT RESEARCH IN FOOD SCIENCE | CURR RES FOOD SCI | 2665-9271 | 6 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2023 | 6.2 | 10.7 | 2.59 | 2025-06-25 | 14 | 17 | MELANOGENESIS; MELANIN; PIGMENTATION; OPTIMIZATION | atrolactic acid; melanocortin; melanocortin 1 receptor; microphthalamia associated transcription factor; monophenol monooxygenase; peptide hormone; probiotic agent; unclassified drug; animal cell; Article; bacterium; bacterium culture; Bifidobacterium; Bifidobacterium bifidum; chemical structure; controlled study; enzyme activity; gas chromatography; gene expression; human; hyperpigmentation; Lactiplantibacillus plantarum; Lactobacillus plantarum; Lactobacillus rhamnosus; mass spectrometry; melanogenesis; melanoma cell line; metabolic fingerprinting; metabolite; metabolomics; molecular docking; nonhuman; protein analysis; protein expression; protein function; protein phosphorylation; skin pigmentation; Western blotting | English | 2023 | 2023 | 10.1016/j.crfs.2022.100413 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Morpho-physiological and genetic characteristics of a salt-tolerant mutant line in soybean (Glycine max L.) | Key messageOne major quantitative trait loci and candidate gene for salt tolerance were identified on chromosome 3 from a new soybean mutant derived from gamma-ray irradiation, which will provide a new genetic resource for improving soybean salt tolerance.Soil salinity is a worldwide problem that reduces crop yields, but the development of salt-tolerant crops can help overcome this challenge. This study was conducted with the purpose of evaluating the morpho-physiological and genetic characteristics of a new salt-tolerant mutant KA-1285 developed using gamma-ray irradiation in soybean (Glycine max L.). The morphological and physiological responses of KA-1285 were compared with salt-sensitive and salt-tolerant genotypes after treatment with 150 mM NaCl for two weeks. In addition, a major salt tolerance quantitative trait locus (QTL) was identified on chromosome 3 in this study using the Daepung X KA-1285 169 F-2:3 population, and a specific deletion was identified in Glyma03g171600 (Wm82.a2.v1) near the QTL region based on re-sequencing analysis. A kompetitive allele-specific PCR (KASP) marker was developed based on the deletion of Glyma03g171600 which distinguished the wild-type and mutant alleles. Through the analysis of gene expression patterns, it was confirmed that Glyma03g171700 (Wm82.a2.v1) is a major gene that controls salt tolerance functions in Glyma03g32900 (Wm82.a1.v1). These results suggest that the gamma-ray-induced mutant KA-1285 has the potential to be employed for the development of a salt-tolerant cultivar and provide useful information for genetic research related to salt tolerance in soybeans. | Moon, Chang Yeok; Kang, Byeong Hee; Kim, Woon Ji; Chowdhury, Sreeparna; Kang, Sehee; Lee, Jeong-Dong; Kwon, Soon-Jae; Kim, Han-Yong; Lee, Hyeon-Seok; Ha, Bo-Keun | Chonnnam Natl Univ, Dept Appl Plant Sci, Gwangju 61186, South Korea; Chonnam Natl Univ, Interdisciplinary Program IT Bio Convergence Syst, Gwangju 61186, South Korea; Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup 56212, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; RDA, Natl Inst Crop Sci, Wonju 55365, South Korea | ; Lee, Hyeonseok/KGL-7243-2024; Kim, Han-Yong/GQR-1012-2022 | 57328072600; 58046054200; 57197826180; 58120616400; 58120506600; 40462075100; 55844795200; 57191720827; 57205348607; 7006749575 | ans3084@gmail.com;rkdqudgml555@naver.com;dnswl007@naver.com;sreeparna1996@gmail.com;wlsgml7026@naver.com;jdlee@knu.ac.kr;soonjaekwon@kaeri.re.kr;hyk1020@jnu.ac.kr;gustjr1029@korea.kr;bkha@jnu.ac.kr; | THEORETICAL AND APPLIED GENETICS | THEOR APPL GENET | 0040-5752 | 1432-2242 | 136 | 7 | SCIE | AGRONOMY;GENETICS & HEREDITY;HORTICULTURE;PLANT SCIENCES | 2023 | 4.4 | 10.7 | 0.73 | 2025-06-25 | 5 | 5 | SALINITY; SEQUENCE; GROWTH; QTL; IDENTIFICATION; MECHANISMS; LOCI; WILD | Alleles; Gamma Rays; Genotype; Polymerase Chain Reaction; Soybeans; Amino acids; Gamma rays; Gene expression; Irradiation; Nitrogen fixation; Physiological models; Physiology; Sodium chloride; Candidate genes; Gamma rays irradiation; Genetic characteristics; Glycine max L; Key message; Mutant lines; Physiological characteristics; Quantitative trait locus; Salt tolerance; Salt tolerant; allele; gamma radiation; genetics; genotype; polymerase chain reaction; soybean; Crops | English | 2023 | 2023-07 | 10.1007/s00122-023-04408-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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