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| ○ | ○ | Article | Climate-associated risks for reliability, resilience, vulnerability and sustainability of irrigation reservoirs in small ungauged watersheds | Climate change poses an existential threat to the functional integrity of the network of agricultural reservoirs responsible for sustaining rice production in South Korea. Anthropogenic interventions have triggered a cycle of droughts and floods by magnifying the already existing supply-demand gap, which is seriously hampering reservoir performance. The watersheds of most agricultural reservoirs in South Korea are ungauged, and inflow and outflow data are not measured. In this study, recorded volumetric water storage data from five reservoirs were used to derive observed inflow data based on the hydrological reasoning and reservoir operation rule curves. These data were then used to evaluate the performance of a lumped rainfall-runoff model in simulating the runoff generated in upstream ungauged watersheds. A water balance analysis was conducted for 400 major agricultural reservoirs spread throughout the country during 1973-2017. Performance indices were estimated based on inflow availability in the reservoirs and downstream irrigation demands. Empirical relationships were derived to predict performance indices by using the reservoirs' physical characteristics as input variables. Generally, reservoirs received substantially higher inflows compared to irrigation demands, suggesting sufficient water availability during the rice growing season (Apr-Sep). An out-of-phase cycle of peak inflow generation and water demand periods induced frequent failure events during the rice nursery transplanting period (May-Jun), and reservoir sustainability was minimal in these months. Southern and southwestern major agricultural regions with a higher density of small-to medium-sized reservoirs would be at higher risk of climate-induced water scarcity. Upsizing storage capacity could alleviate the water deficit in reservoirs associated with watersheds featuring higher means and lower standard deviations of runoff. A watershed-to-irrigated area ratio > 5 indicated acceptable reservoir sustainability. | Ahmad, Mirza Junaid; Choi, Kyung Sook | Kyungpook Natl Univ, Dept Agr Civil Engn, Daegu, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Dept Agr Civil Engn, Daegu, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Dept Agr Civil Engn, 80 Daehak Ro, Daegu, South Korea | Ahmad, Mirza/AAD-5982-2020 | 57201479907; 54392662900 | ks.choi@knu.ac.kr; | CATENA | CATENA | 0341-8162 | 1872-6887 | 234 | SCIE | GEOSCIENCES, MULTIDISCIPLINARY;SOIL SCIENCE;WATER RESOURCES | 2024 | 5.7 | 9.1 | 1.73 | 2025-04-16 | 3 | 3 | Agricultural reservoirs; Water balance; Performance indices; Sustainability | AGRICULTURAL RESERVOIR; PADDY FIELDS; TANK MODEL; REQUIREMENT; EVAPORATION; RUNOFF; MANAGEMENT; OPERATION; LEVEL; RIVER | Agricultural reservoirs; Performance indices; Sustainability; Water balance | South Korea; growing season; inflow; outflow; reservoir; runoff; water availability; water budget; water demand; water storage; watershed | English | 2024 | 2024-01 | 10.1016/j.catena.2023.107632 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Internet of things and ensemble learning-based mental and physical fatigue monitoring for smart construction sites | The construction industry substantially contributes to the economic growth of a country. However, it records a large number of workplace injuries and fatalities annually due to its hesitant adoption of automated safety monitoring systems. To address this critical concern, this study presents a real-time monitoring approach that uses the Internet of Things and ensemble learning. This study leverages wearable sensor technology, such as photoplethysmography and electroencephalography sensors, to continuously track the physiological parameters of construction workers. The sensor data is processed using an ensemble learning approach called the ChronoEnsemble Fatigue Analysis System (CEFAS), comprising deep autoregressive and temporal fusion transformer models, to accurately predict potential physical and mental fatigue. Comprehensive evaluation metrics, including mean square error, mean absolute scaled error, and symmetric mean absolute percentage error, demonstrated the superior prediction accuracy and reliability of the proposed model compared to standalone models. The ensemble learning model exhibited remarkable precision in predicting physical and mental fatigue, as evidenced by the mean square errors of 0.0008 and 0.0033, respectively. The proposed model promptly recognizes potential hazards and irregularities, considerably enhancing worker safety and reducing on-site risks. | Kim, Bubryur; Preethaa, K. R. Sri; Song, Sujeen; Lukacs, R. R.; An, Jinwoo; Chen, Zengshun; An, Euijung; Kim, Sungho | Kyungpook Natl Univ, Sch Space Engn Sci, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea; Vellore Inst Technol, Sch Comp Sci & Engn, Vellore 632014, India; Earth Turbine, 36 Dongdeok Ro 40 Gil, Daegu 41905, South Korea; Kyungpook Natl Univ, Dept Robot & Smart Syst Engn, 80 Daehak Ro, Daegu 41566, South Korea; Univ Texas Rio Grande Valley, Coll Engn & Comp Sci, Dept Civil Engn, Edinburg, TX 78539 USA; Chongqing Univ, Sch Civil Engn, Chongqing 400044, Peoples R China | 57198355299; 57214320928; 58536583500; 59215689800; 56319889200; 55866149500; 59216376900; 57194701745 | babyofbear@gmail.com; | JOURNAL OF BIG DATA | J BIG DATA-GER | 2196-1115 | 11 | 1 | SCIE | COMPUTER SCIENCE, THEORY & METHODS | 2024 | 6.4 | 9.2 | 0.71 | 2025-05-07 | 3 | 4 | Smart construction sites; Internet of things; Ensemble learning; Fatigue monitoring; Safety management; Multivariate time series forecasting | INTRAHEMISPHERIC EEG CORRELATION; SLEEP-DEPRIVATION; WEARABLE SENSORS; WORK HOURS; SAFETY; HEALTH; RISK; CONSEQUENCES; ATTENTION; VIGILANCE | Ensemble learning; Fatigue monitoring; Internet of things; Multivariate time series forecasting; Safety management; Smart construction sites | Occupational risks; Physiological models; Wearable technology; Construction sites; Ensemble learning; Fatigue monitoring; Mental fatigue; Multivariate time series; Multivariate time series forecasting; Physical fatigues; Safety management; Smart construction site; Time series forecasting; Photoplethysmography | English | 2024 | 2024-08-16 | 10.1186/s40537-024-00978-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Uncut fiber analysis using fiber deflection and cutting forces in carbon fiber-reinforced plastics during rotation of the cutting tool | Cutting, milling, and drilling during the manufacture of carbon fiber-reinforced plastics (CFRPs) is an active field of research. It is challenging to analyze cutting characteristics during cutting tool rotation because the chip thickness, fiber cutting angle, and specific cutting force change. Here, we used a mechanical model to study the cutting forces and fiber deflections that develop as the cutting tool rotates during CFRP milling. The fiber and matrix were modeled as a beam, and the cutting force and fiber deflection were analyzed according to the fiber cutting angle. We explored how uncut fiber status and surface roughness were affected. If the fiber deflection caused by transverse cutting forces was not eliminated before the cutting tool rotation angle attained 180 degrees, some fibers were not cut. Serious defects developed when uncut fibers were not generated at certain fiber orientation angles. | Kim, Dong-Gyu; Yang, Seung-Han | Daegu Mechatron & Mat Inst, Adv Cutting Tool Ctr, 3 Seongseogongdan Ro, Daegu 42715, South Korea; Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea | 57966905700; 8407949900 | syang@knu.ac.kr; | COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING | COMPOS PART A-APPL S | 1359-835X | 1878-5840 | 182 | SCIE | ENGINEERING, MANUFACTURING;MATERIALS SCIENCE, COMPOSITES | 2024 | 8.9 | 9.2 | 1.14 | 2025-05-07 | 3 | 4 | CFRP; Cutting force model; Debonding; Fiber deflection; Uncut fiber | GFRP COMPOSITE PIPES; CFRP; DELAMINATION; MECHANISM; DAMAGE | CFRP; Cutting force model; Debonding; Fiber deflection; Uncut fiber | Cutting; Deflection (structures); Fibers; Milling (machining); Surface roughness; Active field; Carbon-fibre reinforced plastics; Cutting angles; Cutting force model; Cutting forces; Cutting tool rotation; Fiber cutting; Fiber deflection; Force deflection; Uncut fiber; Carbon fiber reinforced plastics | English | 2024 | 2024-07 | 10.1016/j.compositesa.2024.108206 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Diabetes Primes Neutrophils for Neutrophil Extracellular Trap Formation through Trained Immunity | Neutrophils are primed for neutrophil extracellular trap (NET) formation during diabetes, and excessive NET formation from primed neutrophils compromises wound healing in patients with diabetes. Here, we demonstrate that trained immunity mediates diabetes -induced NET priming in neutrophils. Under diabetic conditions, neutrophils exhibit robust metabolic reprogramming comprising enhanced glycolysis via the pentose phosphate pathway and fatty acid oxidation, which result in the accumulation of acetyl -coenzyme A. Adenosine 5 ' -triphosphate-citrate lyase-mediated accumulation of acetyl -coenzyme A and histone acetyltransferases further induce the acetylation of lysine residues on histone 3 (AcH3K9, AcH3K14, and AcH3K27) and histone 4 (AcH4K8). The pharmacological inhibition of adenosine 5 ' -triphosphate- citrate lyase and histone acetyltransferases completely inhibited high -glucose -induced NET priming. The trained immunity of neutrophils was further confirmed in neutrophils isolated from patients with diabetes. Our findings suggest that trained immunity mediates functional changes in neutrophils in diabetic environments, and targeting neutrophil-trained immunity may be a potential therapeutic target for controlling inflammatory complications of diabetes. | Shrestha, Sanjeeb; Lee, Yu-Bin; Lee, Hoyul; Choi, Yeon-Kyung; Park, Bo-Yoon; Kim, Mi-Jin; Youn, Young-Jin; Kim, Sun-Hwa; Jung, Soo -Jung; Song, Dong-Keun; Jin, Hee Kyung; Bae, Jae-Sung; Lee, In-Kyu; Jeon, Jae-Han; Hong, Chang-Won; Dk, Song | Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet &, Daegu 41404, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu 41404, South Korea; Hallym Univ, Coll Med, Dept Pharmacol, Chunchon 24252, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Lab Anim Med, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Alzheimers Dis Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41940, South Korea | Kim, Kap/AAG-2863-2020; Bae, Jae-sung/AAM-8663-2021; Youn, Young Jin/KQU-0973-2024; Kim, Young/T-8521-2019 | jeonjh@knu.ac.kr;cwhong@knu.ac.kr; | RESEARCH | RESEARCH-CHINA | 2096-5168 | 2639-5274 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 10.7 | 9.3 | 15 | GLUCOSE; METABOLISM; NETOSIS; ACTIVATION; PATHWAY; BURST; MAPK | English | 2024 | 2024-04-23 | 10.34133/research.0365 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | Review | Adult neurogenesis: a real hope or a delusion? | Adult neurogenesis, the process of creating new neurons, involves the coordinated division, migration, and differentiation of neural stem cells. This process is restricted to neurogenic niches located in two distinct areas of the brain: the subgranular zone of the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle, where new neurons are generated and then migrate to the olfactory bulb. Neurogenesis has been thought to occur only during the embryonic and early postnatal stages and to decline with age due to a continuous depletion of neural stem cells. Interestingly, recent years have seen tremendous progress in our understanding of adult brain neurogenesis, bridging the knowledge gap between embryonic and adult neurogenesis. Here, we discuss the current status of adult brain neurogenesis in light of what we know about neural stem cells. In this notion, we talk about the importance of intracellular signaling molecules in mobilizing endogenous neural stem cell proliferation. Based on the current understanding, we can declare that these molecules play a role in targeting neurogenesis in the mature brain. However, to achieve this goal, we need to avoid the undesired proliferation of neural stem cells by controlling the necessary checkpoints, which can lead to tumorigenesis and prove to be a curse instead of a blessing or hope. Key Words: adult neurogenesis; aging; brain-derived neurotrophic factor; dentate gyrus; | Hussain, Ghulam; Akram, Rabia; Anwar, Haseeb; Sajid, Faiqa; Iman, Tehreem; Han, Hyung Soo; Raza, Chand; De Aguilar, Jose-Luis Gonzalez | Govt Coll Univ, Dept Physiol, Neurochemicalbiol & Genet Lab NGL, Fac Life Sci, Faisalabad, Punjab, Pakistan; Kyungpook Natl Univ, Sch Med, Dept Physiol, Clin Om Inst, Daegu, South Korea; Govt Coll Univ, Fac Chem & Life Sci, Dept Zool, Lahore, Pakistan; INSERM, U1118, Mecanismes Centraux & Peripher Neurodegenerescenc, Strasbourg, France; Univ Strasbourg, Strasbourg, France | Raza, Chand/AAE-3924-2021; HUSSAIN, Ghulam/LLM-1486-2024; Akram, Rabia/KIE-7810-2024 | gh_azer@hotmail.com; | NEURAL REGENERATION RESEARCH | NEURAL REGEN RES | 1673-5374 | 1876-7958 | 19 | 1 | SCIE | CELL BIOLOGY;NEUROSCIENCES | 2024 | 6.7 | 9.4 | 21 | adult neurogenesis; aging; brain-derived neurotrophic factor; dentate gyrus; hippocampus; neural stem cells; neurotrophic factors; Notch; oxidative stress; stem cells; subgranular zone | NEURAL STEM-CELLS; CILIARY NEUROTROPHIC FACTOR; HIPPOCAMPAL NEUROGENESIS; SUBVENTRICULAR ZONE; NEURONAL DIFFERENTIATION; SELF-RENEWAL; SIGNALING PATHWAY; PHYSICAL-EXERCISE; VASCULAR NICHE; PROLIFERATION | English | 2024 | 2024-01 | 10.4103/1673-5374.375317 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Clinical effect of prophylactic pegfilgrastim in patients with newly diagnosed acute lymphoblastic leukemia who receive intensive chemotherapy | BackgroundUsing granulocyte colony-stimulating factor (G-CSF) after completing chemotherapy reduces the duration of neutropenia and infections. However, the efficacy and safety of prophylactic pegfilgrastim in acute lymphoblastic leukemia (ALL) patients have not yet been evaluated after intensive cytotoxic chemotherapy compared to the daily G-CSF. This study aimed to evaluate the efficacy of pegfilgrastim for ALL patients who received intensive chemotherapy compared with a short-acting G-CSF.Patients and methodsClinical data of 145 patients treated with hyper-CVAD, modified VPDL/VPD, or KALLA 1406/1407 regimen were retrospectively evaluated. Pegfilgrastim or the short-acting G-CSF was selected according to the clinician's discretion. Patients not receiving pegfilgrastim were treated with the short-acting G-CSF.ResultsThe median age of enrolled patients was 45 years. Sixty newly diagnosed ALL patients were treated with hyper-CVAD regimen, while KALLA and VPDL regimens were administered to 39 and 46 patients, respectively. Among the 60 patients treated with hyper-CVAD, 20 patients received pegfilgrastim. Patients who received pegfilgrastim had a significantly shorter duration of neutropenia and hospitalization and reduced incidence of severe infections compared to patients receiving the short-acting G-CSF. Consistent results were also confirmed in an analysis targeting only patients who achieved remission during hyper-CVAD induction therapy. There was no significant difference in neutrophil recovery ability and hospitalization duration when the daily short-acting G-CSF was used prophylactically after completing hyper-CVAD, KALLA, and VPDL regimens as induction therapy.ConclusionUsing pegfilgrastim after hyper-CVAD therapy was more effective than the short-acting G-CSF in terms of infection, neutropenia recovery, and hospitalization in patients with newly diagnosed ALL. | Lee, Yunji; Jang, Youngeun; Lee, Jung Min; Cho, Hee Jeong; Moon, Joon Ho; Sohn, Sang Kyun; Ham, Ji Yeon; Chang, Soon Hee; Baek, Dong Won | Kyungpook Natl Univ Hosp, Kyungpook Natl Univ, Sch Med, Dept Hematol Oncol, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Lab Med, Daegu, South Korea | Lee, Jung-Min/L-8227-2016 | 59135707500; 58300323200; 57211561890; 57216754907; 56568642700; 13310226800; 56464754800; 57222602055; 57191874272 | baekdw83@gmail.com; | SUPPORTIVE CARE IN CANCER | SUPPORT CARE CANCER | 0941-4355 | 1433-7339 | 32 | 11 | SCIE | HEALTH CARE SCIENCES & SERVICES;ONCOLOGY;REHABILITATION | 2024 | 3 | 9.5 | 0 | 2025-05-07 | 0 | 0 | Pegfilgrastim; Acute lymphoblastic leukemia; Hyper-CVAD; Neutropenia; Infection | COLONY-STIMULATING FACTOR; FEBRILE NEUTROPENIA; HYPER-CVAD; REGIMEN | Acute lymphoblastic leukemia; Hyper-CVAD; Infection; Neutropenia; Pegfilgrastim | Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Male; Middle Aged; Neutropenia; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins; Retrospective Studies; Young Adult; analgesic agent; cyclophosphamide; cytarabine; dexamethasone; doxorubicin; filgrastim; hydrocortisone; imatinib; lactate dehydrogenase; methotrexate; pegfilgrastim; vincristine; antineoplastic agent; dexamethasone; filgrastim; granulocyte colony stimulating factor; macrogol derivative; pegfilgrastim; recombinant protein; absolute neutrophil count; acute lymphoblastic leukemia; adolescent; adult; aged; allogeneic stem cell transplantation; Article; B cell acute lymphoblastic leukemia; bone pain; cancer combination chemotherapy; cancer regression; cancer survival; controlled study; disease duration; disease severity; drug efficacy; drug megadose; drug safety; febrile neutropenia; female; follow up; hospitalization; human; induction chemotherapy; infection rate; intensive care; leukemia remission; major clinical study; male; medical record review; multiple cycle treatment; neutrophil; overall survival; Philadelphia chromosome positive cell; prophylaxis; retrospective study; T cell acute lymphoblastic leukemia; B cell acute lymphoblastic leukemia; comparative study; drug therapy; middle aged; neutropenia; prevention and control; young adult | English | 2024 | 2024-11 | 10.1007/s00520-024-08926-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Customizable Self-Microemulsifying Rectal Suppositories by Semisolid Extrusion 3D Printing | Objectives: This study aims to create an innovative self-microemulsifying drug delivery system (SMEDDS) suppository for ibuprofen (IBU) using semisolid extrusion (SSE) three-dimensional (3D) printing technology. Methods: Based on solubility studies and the ability to form a transparent microemulsion upon dilution, a selected oil, surfactant, and co-surfactant were utilized to prepare SMEDDS-3DPS containing IBU. The optimal formulation consisted of 10% Triacetin, 80% Gelucire 48/16, and 10% Tetraethylene glycol. SSE 3D printing was employed to create three different-sized suppositories with varying drug contents. These suppositories were assessed for their physicochemical properties, content uniformity, and dissolution profiles. Results: The prepared mixture exhibited suitable physical properties for printing, with nano-sized emulsion droplets providing a large surface area for improved drug absorption in the rectum. Characterization techniques such as differential scanning calorimetry, powder X-ray diffraction, and Fourier transform infrared spectroscopy indicated that IBU was present in the formulation in an amorphous state. Additionally, in vitro dissolution tests demonstrated that SMEDDS-3DPS had a significantly higher initial dissolution rate compared with IBU powder. Conclusions: This research suggests that SMEDDS-3DPS, as a rectal IBU dosage form, can enhance the rectal bioavailability of IBU. It demonstrates the versatility of 3D printing as a novel manufacturing method for lipid-based suppositories and highlights the simplicity and adaptability of SSE 3D printing technology in producing customized suppositories tailored to individual patient needs, surpassing traditional methods. | Park, Hye Jin; Kim, Dong Wuk | Kyungpook Natl Univ, BK21 FOUR Community Based Intelligent Novel Drug D, Vessel Organ Interact Res Ctr VOICE, Res Inst Pharmaceut Sci,Coll Pharm,MRC, Daegu 41566, South Korea | 59441634400; 57193445049 | phj051224@naver.com;dkim17@knu.ac.kr; | PHARMACEUTICS | PHARMACEUTICS | 1999-4923 | 16 | 11 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 5.5 | 9.5 | 0 | 2025-05-07 | 0 | 0 | SMEDDS suppository; ibuprofen; semisolid extrusion 3D printing; dissolution profiles; customized suppositories | DRUG-DELIVERY SYSTEM; IBUPROFEN; FORMULATION; DESIGN; SMEDDS | customized suppositories; dissolution profiles; ibuprofen; semisolid extrusion 3D printing; SMEDDS suppository | ibuprofen; surfactant; Article; differential scanning calorimetry; dissolution; drug absorption; drug delivery system; drug formulation; emulsion; Fourier transform infrared spectroscopy; high performance liquid chromatography; human; microemulsion; photon correlation spectroscopy; physical chemistry; powder X ray diffraction; rectal drug administration; scanning electron microscopy; self microemulsifying drug delivery system; thermodynamics; three dimensional printing; X ray diffraction; zeta potential | English | 2024 | 2024-11 | 10.3390/pharmaceutics16111359 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Discontinuation of blood pressure-lowering, glucose-lowering, and lipid-lowering medications after bariatric surgery in patients with morbid obesity: a nationwide cohort study in South Korea | Background: Limited evidence exists on the patterns of medication use for hypertension, diabetes mellitus (DM), and dyslipidemia after bariatric surgery among Asian patients. Objectives: To investigate the patterns in the use of blood pressure-lowering, glucose-lowering, and lipid-lowering medications following BS in Korean patients with morbid obesity. Setting: This study is a retrospective cohort study using the Health Insurance Review and Assignment claims database of South Korea (from 2019 to 2021). Methods: We included patients who underwent BS between 2019 and 2020 in South Korea. We evaluated the treatment patterns of blood pressure-lowering, glucose-lowering, and lipid-lowering medications at 3-month intervals for 1-year following BS, including medication use, individual medication classes, and the number of medications prescribed. Furthermore, we estimated remission rates for each disorder based on patient characteristics by defining patients who discontinued their medications for at least 2 consecutive quarters as remission. Results: A total of 3810 patients were included in this study. For 1-year following BS, a marked decrease in the number of patients using blood pressure-lowering, glucose-lowering, and lipidlowering medications was observed. The most remarkable decrease occurred in glucose-lowering medications, which decreased by approximately 275.1% compared with that at baseline. This tendency was consistently observed when analyzing both the number of medications prescribed and the specific medication classes. Regarding remission rates, patients who were female, younger, and received the biliopancreatic diversion-duodenal switch as their BS showed a relatively higher incidence of remission than other groups. Conclusions: BS was associated with a decrease in the use of medications for hypertension, diabetes mellitus (DM), and dyslipidemia. (Surg Obes Relat Dis 2024;20:840-848.) (c) 2024 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved. | Jeon, Soo Min; Kwon, Yeongkeun; Kim, Dohyang; Hwang, Jinseub; Heo, Yoonseok; Park, Sungsoo; Kwon, Jin-Won | Jeju Natl Univ, Jeju Res Inst Pharmaceut Sci, Coll Pharm, Jeju, South Korea; Korea Univ, Coll Med, Div Foregut Surg, Seoul, South Korea; Korea Univ, Anam Hosp, Ctr Obes & Metab Dis, Seoul, South Korea; Daegu Univ, Dept Stat, Gyeongbuk, South Korea; Inha Univ, Coll Med, Dept Surg, Incheon, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug D, 80 Daehakro, Daegu 41566, South Korea | Park, Sun-Young/B-4634-2014 | 57206855645; 55970203000; 57218821860; 57189231296; 39361359300; 57187346700; 16202951700 | jwkwon@knu.ac.kr; | SURGERY FOR OBESITY AND RELATED DISEASES | SURG OBES RELAT DIS | 1550-7289 | 1878-7533 | 20 | 9 | SCIE | SURGERY | 2024 | 3.8 | 9.5 | 0 | 2025-05-07 | 1 | 1 | Bariatric surgery; Hypertension; Diabetes mellitus; Dyslipidemia; Medication discontinuation | TYPE-2 DIABETES-MELLITUS; Y GASTRIC BYPASS; SLEEVE GASTRECTOMY; WEIGHT-LOSS; HYPERTENSION; METAANALYSIS; REMISSION; OUTCOMES | Bariatric surgery; Diabetes mellitus; Dyslipidemia; Hypertension; Medication discontinuation | Adult; Antihypertensive Agents; Bariatric Surgery; Cohort Studies; Diabetes Mellitus; Dyslipidemias; Female; Humans; Hypertension; Hypoglycemic Agents; Hypolipidemic Agents; Male; Middle Aged; Obesity, Morbid; Republic of Korea; Retrospective Studies; 2,4 thiazolidinedione derivative; alpha glucosidase inhibitor; angiotensin receptor antagonist; antidiabetic agent; antihypertensive agent; antilipemic agent; beta adrenergic receptor blocking agent; calcium channel blocking agent; dipeptidyl carboxypeptidase inhibitor; dipeptidyl peptidase IV inhibitor; diuretic agent; hydroxymethylglutaryl coenzyme A reductase inhibitor; insulin derivative; meglitinide; metformin; sodium glucose cotransporter inhibitor; sulfonylurea; adult; Article; bariatric surgery; biliopancreatic diversion with duodenal switch; blood pressure; cohort analysis; controlled study; coronary artery disease; diabetes mellitus; drug withdrawal; dyslipidemia; economic vulnerability; female; gastric banding; health insurance; human; hypertension; ICD-10; major clinical study; male; morbid obesity; obstructive sleep apnea; osteoarthritis; ovary polycystic disease; prescription; remission; retrospective study; Roux-en-Y gastric bypass; sleeve gastrectomy; South Korea; complication; diabetes mellitus; drug therapy; dyslipidemia; epidemiology; hypertension; middle aged; morbid obesity; surgery | English | 2024 | 2024-09 | 10.1016/j.soard.2024.03.008 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Evaluation of the Drug-Induced Liver Injury Potential of Saxagliptin through Reactive Metabolite Identification in Rats | A liver injury was recently reported for saxagliptin, which is a dipeptidyl peptidase-4 (DPP-4) inhibitor. However, the underlying mechanisms of saxagliptin-induced liver injury remain unknown. This study aimed to evaluate whether saxagliptin, a potent and selective DPP-4 inhibitor that is globally used for treating type 2 diabetes mellitus, binds to the nucleophiles in vitro. Four DPP-4 inhibitors, including vildagliptin, were evaluated for comparison. Only saxagliptin and vildagliptin, which both contain a cyanopyrrolidine group, quickly reacted with L-cysteine to enzyme-independently produce thiazolinic acid metabolites. This saxagliptin-cysteine adduct was also found in saxagliptin-administered male Sprague-Dawley rats. In addition, this study newly identified cysteinyl glycine conjugates of saxagliptin and 5-hydroxysaxagliptin. The observed metabolic pathways were hydroxylation and conjugation with cysteine, glutathione, sulfate, and glucuronide. In summary, we determined four new thiazoline-containing thiol metabolites (cysteine and cysteinylglycine conjugates of saxagliptin and 5-hydroxysaxagliptin) in saxagliptin-administered male rats. Our results reveal that saxagliptin can covalently bind to the thiol groups of cysteine residues of endogenous proteins in vivo, indicating the potential for saxagliptin to cause drug-induced liver injury. | Kim, Ki-Young; Jeong, Yeo-Jin; Park, So-Young; Park, Eun-Ji; Jeon, Ji-Hyeon; Song, Im-Sook; Liu, Kwang-Hyeon | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, BK21 FOUR KNU Community,Based Intelligent Novel Dr, Daegu 41566, South Korea; Kyungpook Natl Univ, Mass Spectrometry Based Convergence Res Inst, Daegu 41566, South Korea | Kim, Kyung-Min Kim/C-7007-2014 | 58032476400; 57224538974; 57211630074; 57203611956; 57204685946; 7201564500; 55768214700 | neanic12@naver.com;duwls9902@gmail.com;soyoung561@hanmail.net;roseej98@naver.com;kei7016@naver.com;isssong@knu.ac.kr;dstlkh@knu.ac.kr; | PHARMACEUTICS | PHARMACEUTICS | 1999-4923 | 16 | 1 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 5.5 | 9.5 | 1.09 | 2025-04-16 | 2 | 2 | drug-induced liver injury; glutathione; metabolism; saxagliptin; vildagliptin | IN-VITRO; COVALENT BINDING; HEPATOTOXICITY; DISPOSITION; LINAGLIPTIN; INHIBITOR | drug-induced liver injury; glutathione; metabolism; saxagliptin; vildagliptin | cysteine; cysteine conjugate; dipeptidyl peptidase IV inhibitor; gamma glutamyltransferase; glucuronide; glutathione; glycine; saxagliptin; sodium chloride; thiol group; trelagliptin; vildagliptin; animal model; Article; bicinchoninic acid assay; blood sampling; cholestasis; controlled study; cyclization; diabetes mellitus; drug-induced liver injury; glomerulus filtration rate; high performance liquid chromatography; hydroxylation; immunogenicity; liquid chromatography-mass spectrometry; liver biopsy; liver injury; liver microsome; male; mass spectrometry; metabolite; non insulin dependent diabetes mellitus; nonhuman; quadrupole mass spectrometry; rat; receiver operating characteristic; retention time | English | 2024 | 2024-01 | 10.3390/pharmaceutics16010106 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | In Vitro Metabolism and Transport Characteristics of Zastaprazan | Zastaprazan (JP-1366), a novel potassium-competitive acid blocker, is a new drug for the treatment of erosive esophagitis. JP-1366 is highly metabolized in human, mouse, and dog hepatocytes but moderately metabolized in rat and monkey hepatocytes when estimated from the metabolic stability of this compound in hepatocyte suspension and when 18 phase I metabolites and 5 phase II metabolites [i.e., N-dearylation (M6), hydroxylation (M1, M19, M21), dihydroxylation (M7, M8, M14, M22), trihydroxylation (M13, M18), hydroxylation and reduction (M20), dihydroxylation and reduction (M9, M16), hydrolysis (M23), hydroxylation and glucuronidation (M11, M15), hydroxylation and sulfation (M17), dihydroxylation and sulfation (M10, M12), N-dearylation and hydroxylation (M3, M4), N-dearylation and dihydroxylation (M5), and N-dearylation and trihydroxylation (M2)] were identified from JP-1366 incubation with the hepatocytes from humans, mice, rats, dogs, and monkeys. Based on the cytochrome P450 (CYP) screening test and immune-inhibition analysis with CYP antibodies, CYP3A4 and CYP3A5 played major roles in the metabolism of JP-1366 to M1, M3, M4, M6, M8, M9, M13, M14, M16, M18, M19, M21, and M22. CYP1A2, 2C8, 2C9, 2C19, and 2D6 played minor roles in the metabolism of JP-1366. UDP-glucuronosyltransferase (UGT) 2B7 and UGT2B17 were responsible for the glucuronidation of M1 to M15. However, JP-1366 and active metabolite M1 were not substrates for drug transporters such as organic cation transporter (OCT) 1/2, organic anion transporter (OAT) 1/3, organic anion transporting polypeptide (OATP)1B1/1B3, multidrug and toxic compound extrusion (MATE)1/2K, P-glycoprotein (P-gp), and breast cancer-resistant protein (BCRP). Only M1 showed substrate specificity for P-gp. The findings indicated that drug-metabolizing enzymes, particularly CYP3A4/3A5, may have a significant role in determining the pharmacokinetics of zastaprazan while drug transporters may only have a small impact on the absorption, distribution, and excretion of this compound. | Lee, Min Seo; Lee, Jihoon; Pang, Minyoung; Kim, John; Cha, Hyunju; Cheon, Banyoon; Choi, Min-Koo; Song, Im-Sook; Lee, Hye Suk | Catholic Univ Korea, Coll Pharm, Bucheon 14662, South Korea; Catholic Univ Korea, Sponsored Adv Program Smart Pharma Leaders BK21 44, Bucheon 14662, South Korea; Kyungpook Natl Univ, BK21 FOUR Community Based Intelligent Novel Drug, Vessel Organ Interact Res Ctr VOICE, Res Inst Pharmaceut Sci,Coll Pharm, Daegu 41566, South Korea; Keimyung Univ, Coll Pharm, Daegu 30019, South Korea; Oncon Therapeut Inc, Seoul, South Korea | 57225079010; 57195979045; 57488599500; 58091036400; 56684212200; 58256527700; 8695781400; 7201564500; 35316111800 | minseo.lee@catholic.ac.kr;legadema0905@knu.ac.kr;mignon@dankook.ac.kr;john.kim@onconic.co.kr;hj.cha@onconic.co.kr;bycheon@onconic.co.kr;minkoochoi@dankook.ac.kr;isssong@knu.ac.kr;sianalee@catholic.ac.kr; | PHARMACEUTICS | PHARMACEUTICS | 1999-4923 | 16 | 6 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 5.5 | 9.5 | 0.98 | 2025-05-07 | 2 | 5 | zastaprazan (JP-1366); potassium-competitive acid blocker (P-CAB); metabolite identification; drug-metabolizing enzymes; drug transporters | DRUG DEVELOPMENT; INHIBITOR | drug transporters; drug-metabolizing enzymes; metabolite identification; potassium-competitive acid blocker (P-CAB); zastaprazan (JP-1366) | ABC transporter subfamily B; breast cancer resistance protein; cytochrome P450; cytochrome P450 1A2; cytochrome P450 3A4; cytochrome P450 3A5; drug metabolizing enzyme; glucuronosyltransferase; organic anion transporter; organic cation transporter; potassium competitive acid blocker; zastaprazan; Article; breast cancer; dihydroxylation; drug transport; enzyme specificity; esophagitis; glucuronidation; hydrolysis; hydroxylation; in vitro study; metabolic stability; nonhuman; reflux esophagitis; sulfation | English | 2024 | 2024-06 | 10.3390/pharmaceutics16060799 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Pharmacokinetics and Enterohepatic Circulation of 2-(Quinoline-8-carboxamido)benzoic Acid (2-QBA) in Mice | The quinoline alkaloid 2-(quinoline-8-carboxamido)benzoic acid (2-QBA), which is isolated from Aspergillus sp. SCSIO06786, a deep sea-derived fungus, has been suggested as a therapeutic candidate for the treatment of Parkinson's disease. We developed an analytical method for 2-QBA using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) in mouse plasma, in which a protein precipitation method for the sample preparation of 2-QBA in mouse plasma was used due to its simplicity and good extraction recovery rates (80.49-97.56%). The linearity of the calibration standard sample, inter- and intraday precision and accuracy, and stability of three quality control samples were suitable based on the assessment criteria and the lower limit of quantification (LLOQ) of the 2-QBA was 1 ng/mL. A pharmacokinetic study of 2-QBA was performed in mice divided into oral (2.0, 5.0, and 15 mg/kg) and intravenous (0.5 and 1.0 mg/kg) administration groups. The absolute oral bioavailability (BA) range of 2-QBA was calculated as 68.3-83.7%. Secondary peaks were observed at approximately 4-8 h after the oral administration of 2-QBA at all doses. The elimination half-life of the orally administered 2-QBA was significantly longer than that of the intravenous 2-QBA. In addition, glucuronide metabolites of 2-QBA were identified. They were transformed into 2-QBA using the beta-glucuronidase treatment. Furthermore, the 2-QBA was readily absorbed from the jejunum to lower ileum. Taken together, the secondary peaks could be explained by the enterohepatic circulation of 2-QBA. In conclusion, the reabsorption of orally administered 2-QBA could contribute to the high oral BA of 2-QBA and could be beneficial for the efficacy of 2-QBA. Moreover, the simple and validated analytical method for 2-QBA using LC-MS/MS was applied to the pharmacokinetic study and BA assessments of 2-QBA in mice and would be helpful for subsequent pharmacokinetic studies, as well as for evaluations of the toxicokinetics and pharmacokinetic-pharmacodynamic correlation of 2-QBA to assess its potential as a drug. | Jeon, Ji-Hyeon; Jeon, So-Yeon; Baek, Yeon-Ju; Park, Chan-E; Choi, Min-Koo; Han, Young Taek; Song, Im-Sook | Kyungpook Natl Univ, BK21 FOUR Community Based Intelligent Novel Drug, Coll Pharm, Vessel Organ Interact Res Ctr VOICE, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Dankook Univ, Coll Pharm, Cheonan 31116, South Korea | 57204685946; 57226815842; 59234812100; 59234812200; 8695781400; 36097949800; 7201564500 | yoummseggh@knu.ac.kr;jeonsy@dankook.ac.kr;yeonju4227@dankook.ac.kr;72230411dku@dankook.ac.kr;minkoochoi@dankook.ac.kr;hany@dankook.ac.kr;isssong@knu.ac.kr; | PHARMACEUTICS | PHARMACEUTICS | 1999-4923 | 16 | 7 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 5.5 | 9.5 | 0.49 | 2025-05-07 | 2 | 2 | 2-(quinoline-8-carboxamido)benzoic acid (2-QBA); liquid chromatography-tandem mass spectrometry; pharmacokinetics; enterohepatic circulation | ACTIVATED-CHARCOAL; ABSORPTION; RECIRCULATION; EXCRETION; GENISTEIN; PROGRESSION; METABOLISM; DISEASE; AGENTS; RATS | 2-(quinoline-8-carboxamido)benzoic acid (2-QBA); enterohepatic circulation; liquid chromatography–tandem mass spectrometry; pharmacokinetics | 2 quinoline 8 carboxamido benzoic acid; benzoic acid; berberine; beta glucuronidase; formic acid; glucuronide; quinoline; unclassified drug; analytic method; Article; Aspergillus; bioavailability; calibration; controlled study; electrospray; elimination half-life; enterohepatic circulation; high performance liquid chromatography; histology; jejunum; limit of quantitation; liquid chromatography-mass spectrometry; mass spectrometry; measurement accuracy; metabolite; mouse; multiple reaction monitoring; nonhuman; oxygenation; Parkinson disease; pharmacodynamics; pharmacokinetic parameters; precipitation; quality control; regression analysis; terminal ileum; urinary excretion; validation process; volume of distribution | English | 2024 | 2024-07 | 10.3390/pharmaceutics16070934 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Correction | Preliminary outcomes of the LifeStream balloon-expandable stentgraft in Zenith Iliac branch device to preserve pelvic circulation: A Korean multicenter study (vol 46, pg 94, 2023) | Yang, Shin-Seok; Kim, Hyung-Kee; Kim, Jang-Yong; Lee, Taeseung; Lee, Sang-Su; Park, Hyung-Sub; Park, Sun-Cheol; Park, Yang-Jin | Samsung Med Ctr, Dept Surg, Div Vasc Surg, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Catholic Univ Korea, Coll Med, Dept Surg, Div Vasc & Transplant Surg, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Surg, Div Vasc Surg, Seongnam, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Surg, Div Vasc & EndoVasc Surg, Yangsan, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Div Vasc Surg,Dept Surg, 81 Irwonro, Seoul 06351, South Korea | ; KIM, JANGYONG/AAS-2145-2021; Kim, Hyung-Kee/JBR-8125-2023; park, yj/O-6243-2014 | 54400594300; 35169819900; 57218494551; 7501437724; 57192663025; 46161622600; 16638985800; 24367068100 | yjpark1974@skku.edu; | ASIAN JOURNAL OF SURGERY | ASIAN J SURG | 1015-9584 | 0219-3108 | 47 | 7 | SCIE | SURGERY | 2024 | 3.8 | 9.5 | 0 | 2025-05-07 | 0 | 0 | Asian; balloon; clinical article; complication; diagnosis; erratum; female; human; iliac bone; middle aged; multicenter study; pelvis | English | 2024 | 2024-07 | 10.1016/j.asjsur.2024.04.091 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | RSSGLT: Remote Sensing Image Segmentation Network Based on Global-Local Transformer | Remotely captured images possess an immense scale and object appearance variability due to the complex scene. It becomes challenging to capture the underlying attributes in the global and local context for their segmentation. Existing networks struggle to capture the inherent features due to the cluttered background. To address these issues, we propose a remote sensing image segmentation network, RSSGLT, for semantic segmentation of remote sensing images. We capture the global and local features by leveraging the benefits of the transformer and convolution mechanisms. RSSGLT is an encoder-decoder design that uses multiscale features. We construct an attention map module (AMM) to generate channelwise attention scores for fusing these features. We construct a global-local transformer block (GLTB) in the decoder network to support learning robust representations during a decoding phase. Furthermore, we designed a feature refinement module (FRM) to refine the fused output of the shallow stage encoder feature and the deepest GLTB feature of the decoder. Experimental findings on the two public datasets show the effectiveness of the proposed RSSGLT. | Kumar, Satyawant; Kumar, Abhishek; Lee, Dong-Gyu | Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea | Kumar, Abhishek/ABA-5251-2021 | 58029499800; 57206266703; 57169003900 | dglee@knu.ac.kr; | IEEE GEOSCIENCE AND REMOTE SENSING LETTERS | IEEE GEOSCI REMOTE S | 1545-598X | 1558-0571 | 21 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;GEOCHEMISTRY & GEOPHYSICS;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING | 2024 | 4.4 | 9.5 | 2.61 | 2025-04-16 | 7 | 7 | Transformers; Decoding; Image segmentation; Remote sensing; Convolution; Feature extraction; Semantics; Context details; multiscale features; remote sensing images; semantic segmentation; transformer | Context details; multiscale features; remote sensing images; semantic segmentation; transformer | Decoding; Remote sensing; Semantics; Signal encoding; Complex scenes; Context detail; Global-local; Images segmentations; Multi-scale features; Network-based; Object appearance; Remote sensing images; Semantic segmentation; Transformer; design; remote sensing; satellite imagery; segmentation; Semantic Segmentation | English | 2024 | 2024 | 10.1109/lgrs.2023.3337879 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Energy- and yield-based performance evaluation of a phase change material-integrated single-span double-layered with a thermal screen greenhouse | Greenhouse technology emerged to ensure the optimum yield of the host crop -a prerequisite to achieving Sustainable Development Goals 7 and 2. To achieve this, supplemental energy is needed under extreme weather conditions at about half the operational cost. Researchers have focused and succeeded in reducing the energy demand using numerical methods with little focus on the impact of these methods on crop yield. A novel greenhouse system-phase change material-integrated single-span double-layered strawberry greenhouse with a thermal screen-is introduced herein. Furthermore, how the energy management method affects the yield of the host crop is explored. Moreover, the energy-saving potential and yield enhancement achieved by integrating PCMs and other passive thermal-management systems in a specific agricultural setting is investigated. TRNSYS 18 software is used to evaluate the effect of three passive variables on two performance indices. The passive variables are location: Daegu (DG), Seoul, and Jeju Island (JE); orientation: 90 degrees (E-W), 45 degrees (NE-SW), and 0 degrees (NS); and PCM type: "No-fill", water, and Paraffin (ParC13-C24). The effect of thermal screen control was also studied on the localized optium configuration. Finally, economic analysis was conducted to ascertain the most sustainable configuration. The performance indices are the heating demand and strawberry yield. The results show that the location, orientation, and PCM usage inside the greenhouse greatly affect the greenhouse's heating demand and crop yield. The configuration selected must be in such a way that the indoor nighttime temperature does not exceed 2 degrees C above the minimum nighttime optimum value of the host crop. | Ogunlowo, Qazeem Opeyemi; Akpenpun, Timothy Denen; Adesanya, Misbaudeen Aderemi; Rabiu, Anis; Dutta, Prabhat; Kim, Hyeon-Tae; Lee, Hyun-Woo | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Agr Civil Engn, Daegu 41566, South Korea; Fed Coll Agr Ibadan, Dept Agr & Bioenvironm Engn, PMB 5029, Ibadan, Nigeria; Kyungpook Natl Univ, Smart Agr Innovat Ctr, Daegu 41566, South Korea; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin 240003, Nigeria; Kyungpook Natl Univ, Dept Food Secur & Agr Dev, Daegu 702701, South Korea; Gyeongsang Natl Univ, Dept Bioind Machinery, Jinju 52828, South Korea | ; Adesanya, Misbaudeen/AAA-4664-2022; OGUNLOWO, QAZEEM/ABB-5386-2021; RABIU, Anis/JXO-1947-2024 | 57265471800; 58928513600; 57211208368; 57264527200; 57264527100; 58704737600; 8662923200; 57209160180 | whlee@knu.ac.kr; | THERMAL SCIENCE AND ENGINEERING PROGRESS | THERM SCI ENG PROG | 2451-9049 | 50 | SCIE | ENERGY & FUELS;ENGINEERING, MECHANICAL;MECHANICS;THERMODYNAMICS | 2024 | 5.4 | 9.6 | 0.74 | 2025-05-07 | 4 | 3 | Greenhouse evaluation; Energy management; Heating demand; Strawberry yield; PCM-integration; Economic analysis | STORAGE; TEMPERATURE | Economic analysis; Energy management; Greenhouse evaluation; Heating demand; PCM-integration; Strawberry yield | Crops; Economic analysis; Energy conservation; Energy management; Fruits; Numerical methods; Optimal systems; Phase change materials; Crop yield; Double layered; Economics analysis; Energy; Greenhouse evaluation; Heating demand; Host crops; PCM-integration; Strawberry yield; Thermal screen; Greenhouses | English | 2024 | 2024-05 | 10.1016/j.tsep.2024.102499 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Enhancing Part-Load performance of the simple recuperated supercritical carbon dioxide cycle through shaft separation | In this study, the operability of a simple recuperated supercritical carbon dioxide (S-CO2) cycle under off-design conditions, specifically during part-load operation, was quantitatively analyzed by implementing shaft separation to place a compressor-driving turbine (CDT). For off-design evaluation, both the heat exchanger and turbomachinery were designed in one dimension before being inserted into the off-design platform of the system. To ensure physical consistency, all turbines were designed using the same set of loss models. The analysis results revealed that the efficiency of the single-shaft configuration decreased by about 12 %p at 10 % output, while that of the separated-shaft configuration decreased by < 8 %p under the same conditions. The arrangement of the CDT and power turbine had minimal impacts on off-design performance. The power required to drive the CDT-compressor operating at the optimal Revolution Per Minuate was found to be less than 5 % of the design output. These findings imply that layout modifications can enhance overall off-design efficiency and that the incorporation of a motor that supplies about 5 % of the design output for the CDT-compressor set significantly improves part-load operability. This requirement is practical, as such a motor is typically required for startup procedures. Although these results were obtained from the simplest recuperated S-CO2 cycle, similar approaches could enhance off-design performance in more complex cycles such as waste heat recovery or S-CO2 recompression cycles. The findings of this study demonstrate that altering the shaft arrangement while considering off-design operability can significantly enhance the operability of S-CO2 systems. | Son, Seongmin | Kyungpook Natl Univ, Dept Convergence & Fus Syst Engn, 80 Daehak ro, Daegu, South Korea | Son, Seongmin/KHU-6666-2024 | 56681720100 | seongminson@knu.ac.kr; | THERMAL SCIENCE AND ENGINEERING PROGRESS | THERM SCI ENG PROG | 2451-9049 | 56 | SCIE | ENERGY & FUELS;ENGINEERING, MECHANICAL;MECHANICS;THERMODYNAMICS | 2024 | 5.4 | 9.6 | 0 | 2025-05-07 | 0 | 0 | Supercritical CO (2); Simple recuperated cycle; Part-load operation; Shaft configuration; Turbomachinery; Off-design analysis | Off-design analysis; Part-load operation; Shaft configuration; Simple recuperated cycle; Supercritical CO<sub>2</sub>; Turbomachinery | Compressors; Liquefied gases; Supercritical fluid extraction; Waste heat utilization; Off designs; Off-design analysis; Off-design performance; Part load; Part load operation; Shaft configuration; Simple recuperated cycle; Simple++; Supercritical carbondioxides; Supercritical CO 2; Waste heat | English | 2024 | 2024-12 | 10.1016/j.tsep.2024.103074 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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