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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Deformation mechanisms and mechanical properties of rolled AZ31 alloy subjected to precompression and subsequent annealing: Effect of annealing temperature | This study investigates the effect of annealing temperature on the microstructure, deformation behavior, and mechanical properties of a rolled AZ31 alloy having {10-12} twins. To this end, rolled AZ31 samples are precompressed to 6.0% along the rolling direction (RD) to introduce {10-12} twins and then are annealed at 200, 250, and 300 degrees C for 1 h. The results reveal that as the annealing temperature increases, the grain size of the annealed samples increases and their RD-oriented basal texture is strengthened. In addition, the number of {10-12} twin boundaries gradually decreases and they almost disappear after annealing at 300 degrees C. Under tension along the RD, the predominant deformation mechanism of the annealed samples changes from detwinning of preexisting twins to {10-12} twinning as the annealing temperature increases. The annealed samples exhibit different tensile strengths and elongations according to the annealing temperature. Particularly, the tensile elongation increases by 56%, from 13.2% to 20.6%, as the annealing temperature increases from 200 to 300 degrees C. The variations in the mechanical properties of the annealed samples with the annealing temperature are discussed in detail on the basis of their microstructural characteristics and deformation behaviors. | Kim, Ye Jin; Kim, Hyun Ji; Park, Sung Hyuk | Missile Res Inst, Agcy Def Dev, Daejeon 34060, South Korea; Kyungpook Natl Univ, Dept Mat Sci & Met Engn, Daegu 41566, South Korea | Kim, Hyunjin/MDS-5282-2025 | 59052467200; 59866513600; 54786002500 | sh.park@knu.ac.kr; | MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING | MAT SCI ENG A-STRUCT | 0921-5093 | 1873-4936 | 899 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 7 | 8.9 | 1.62 | 2025-05-07 | 5 | 5 | Rolled Mg alloy; Annealing; Twinning; Detwinning; Mechanical properties | MAGNESIUM ALLOY; GRAIN-SIZE; MICROSTRUCTURAL EVOLUTION; MG-3AL-1ZN ALLOY; BEHAVIOR; TEXTURE; RECRYSTALLIZATION; FORMABILITY; FRACTURE; STRESS | Annealing; Detwinning; Mechanical properties; Rolled Mg alloy; Twinning | Magnesium alloys; Tensile strength; Textures; Annealed samples; Annealing; Annealing temperatures; AZ31 alloy; Deformation mechanism; Detwinning; Mg alloy; Rolled mg alloy; Rolling direction; Temperature increase; Annealing | English | 2024 | 2024-05 | 10.1016/j.msea.2024.146424 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Design strategy for high-entropy alloys with enhanced microstructural stability and mechanical properties for high-temperature applications | The use of AlCoCrFeNi high-entropy alloy as high-temperature structural materials is limited because of their phase instability. To address this, we designed Co-free Al-Cr-Fe-Ni alloys with spinodal structures composed of disordered body-centered cubic (BCC) (A2) and ordered BCC (B2) phases. The effect of Al and Ni content on the phase fractions and that of the Cr content on the microstructure and B2 precipitate size were evaluated. The composition of the alloy was optimized to enhance its microstructural stability and room-temperature machinability. Finally, Al13.6Cr(x)Fe(75.2-x)Ni11.2 alloys were designed and investigated for their phase stability and mechanical properties at both ambient and elevated temperatures. The fabricated Al13.6Cr(x)Fe(75.2-x)Ni11.2 alloys exhibited adequate phase stability at high temperatures. Particularly, as the Al13.6Cr13.3Fe61.9Ni11.2 (13Cr) alloy exhibited ductility of 1.3 % at 298 K, it can be a potential candidate as a high-temperature structural material. These findings suggest a promising design strategy for high-entropy alloys. | Kwon, Heoun-Jun; Lim, Ka Ram; Kim, Young Kyun; Na, Young Sang; Yi, Seonghoon | Kyungpook Natl Univ, Dept Mat Sci & Met Engn, Daegu 41566, South Korea; Korea Inst Mat Sci KIMS, Dept Special Alloys, Chang Won 51508, South Korea | ; Kim, Kyung Il/ABE-1592-2021; Yi, Seonghoon/HGC-6912-2022; Na, Young-Sang/LRS-9195-2024 | 57200340382; 36449808200; 57202950363; 7006088542; 14008383000 | krlim@kims.re.kr;yish@knu.ac.kr; | MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING | MAT SCI ENG A-STRUCT | 0921-5093 | 1873-4936 | 889 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 7 | 8.9 | 2.14 | 2025-04-16 | 6 | 7 | High -entropy alloy; Heat -resistant material; Phase stability; Microstructure; Mechanical property | YIELD STRENGTH; BEHAVIOR; DEFORMATION; EVOLUTION; DUCTILITY; CREEP | Heat-resistant material; High-entropy alloy; Mechanical property; Microstructure; Phase stability | Aluminum alloys; Chromium alloys; Cobalt alloys; Crystal structure; Entropy; High temperature applications; High-entropy alloys; Iron alloys; Microstructure; Nickel alloys; Precipitation (chemical); Ternary alloys; Body-centred cubic; Co-free; Cr-Fe-Ni; Design strategies; Heat resistant material; High entropy alloys; High-temperature application; High-temperature structural materials; Microstructural stability; Phase instability; Phase stability | English | 2024 | 2024-01 | 10.1016/j.msea.2023.145836 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Investigating oxidant-catalyst interactions in the persulfate system: Implications for efficient removal of phenolics and antibiotics | Persulfate (PS) activation by carbon catalyst holds both scientific and practical significance to curb the toxicity effects of organic pollutants in the natural water environment. Here, we investigated a relatively unfamiliar characteristics (i.e., oxidant-catalyst interaction) that influence the removal efficiency in PS activated system, utilizing N-doped mesoporous carbon hollow spheres (N-MCHS; size -385 nm) as a catalyst. The selection of this catalyst was motivated by its desired physicochemical characteristics such as high dispersibility, uniformly distributed pores and high specific surface area (1109 m2 g-1) for catalytic application. The removal performance was studied by degrading bisphenol A at very low PS (0.25 mM) and catalyst (10.0 mg L-1) concentrations. Through this study, we established a correlation between the surface charge of N-MCHS and PS interaction on the catalytic performance. Further, electron spin resonance (ESR) and radical scavenger studies were carryout out to prove the nonradical oxidation process. Electrochemical studies provided a strong evidence for PS complexation and electron transfer during oxidative removal of bisphenol A. Additional studies with different phenolics and antibiotics demonstrated that N-doping significantly accelerates the degradation rate and enhances the removal efficiency. The results of present study unveil the potential use of PS+N-MCHS in the degradation of different organic contaminants at low catalyst dosages. | Kumar, Alam Venugopal Narendra; Shin, Won Sik | Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, Daegu 41566, South Korea | 39262149400; 23019870800 | wshin@knu.ac.kr; | SEPARATION AND PURIFICATION TECHNOLOGY | SEP PURIF TECHNOL | 1383-5866 | 1873-3794 | 344 | SCIE | ENGINEERING, CHEMICAL | 2024 | 9 | 8.9 | 0.41 | 2025-05-07 | 3 | 3 | Porous carbon; N -doping; Water remediation; Persulfate activation; Pollutant degradation | POROUS CARBON; BISPHENOL-A; DEGRADATION; PEROXYMONOSULFATE; WATER | N-doping; Persulfate activation; Pollutant degradation; Porous carbon; Water remediation | Antibiotics; Carbon; Chemical activation; Degradation; Doping (additives); Efficiency; Electron spin resonance spectroscopy; Free radical reactions; Free radicals; Magnetic moments; Organic pollutants; Oxidants; Phenols; Porous materials; Water pollution; Water treatment; Bisphenols-A; N-Doping; Persulfate activations; Persulphate; Phenolics; Pollutant degradation; Porous carbons; Removal efficiencies; Water remediation; ]+ catalyst; Catalysts | English | 2024 | 2024-09-20 | 10.1016/j.seppur.2024.127210 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Metallic cobalt-anchored carbon with non-metallic heteroatom decoration: Remarkably effective oxidative desulfurization catalyst | The discovery of low-cost, highly effective, and novel catalytic materials for oxidative desulfurization (ODS) of liquid fuel is an important topic in the field of heterogeneous catalysis from both academic and industrial viewpoints. Different metallic active component supported on porous carbon was found as effective catalysts for ODS reactions and the contribution of the secondary or non-metallic heteroatom decoration on the carbon was also assumed. However, the precise role of the doped heteroatom(s) on boosting the ODS process is unknown. Here, a new approach to prepare a series of cobalt-anchored porous carbon (Co@C) with different heteroatom co-dopants (i.e., N, P, and B) and their effects on boosting oxidative desulfurization (ODS) from fuel were firstly instigated. The Co@nitroneneous carbons with P or B co-dopants could be derived via the carbonization of a bimetallic MOF with extra N, P, and B sources. A newly designed/developed Co@C catalyst exhibited high intrinsic activities in ODS. Importantly, Co@C having suitable N and P contents had an extremely low Ea (21 KJ & sdot;mol-1) and the highest TOF (104 h-1), among the studied/reported materials, for the oxidation of dibenzo-thiophene. We also firstly demonstrate the precise role of doped heteroatoms in Co@C in accelerating ODS by the synergy between doped heteroatoms and the reduction of the HOMO-LUMO energy gap of the catalyst. This approach can pave the way for tuning the catalytic performance through atom-level surface modification of carbonaceous catalysts. | Bhadra, Biswa Nath; Mondol, Md Mahmudul Hassan; Jhung, Sung Hwa | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Khulna Univ Engn & Technol KUET, Dept Chem Engn, Khulna 9203, Bangladesh | Jhung, Sung/AAO-6683-2021; Hassan Mondol, Md Mahmudul/AAM-8718-2021; Bhadra, Biswa/ABG-6935-2021; Bhadra, Biswa Nath/ABG-6935-2021 | 56982844300; 57217989090; 6701659467 | sung@knu.ac.kr; | SEPARATION AND PURIFICATION TECHNOLOGY | SEP PURIF TECHNOL | 1383-5866 | 1873-3794 | 330 | SCIE | ENGINEERING, CHEMICAL | 2024 | 9 | 8.9 | 2.9 | 2025-05-07 | 14 | 16 | Carbon; Cobalt; Heteroatom doping; Oxidative desulfurization; Phosphorous | NITROGEN; GRAPHENE; BORON | Carbon; Cobalt; Heteroatom doping; Oxidative desulfurization; Phosphorous | Carbonization; Catalysis; Catalyst activity; Cobalt; Costs; Phosphorus; Porous materials; Co-dopants; Heteroatom doping; Heteroatoms; Low-costs; Metallic cobalt; Non-metallic; Oxidative desulfurization; Phosphorous; Porous carbons; ]+ catalyst; Carbon | English | 2024 | 2024-02-01 | 10.1016/j.seppur.2023.125425 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | MHCanonNet: Multi-Hypothesis Canonical lifting Network for 3D human estimation in the wild video | Recent advancements in 3D Human Pose Estimation using fully-supervised learning approach have shown impressive results; however, these methods heavily rely on large amounts of annotated 3D data, which are challenging to obtain outside controlled laboratory environments. Therefore, in this study, we propose a new self-supervised training method designed to train a 3D human pose estimation network using unlabeled multi-view images. The model trains relative depths between joints without any 3D annotation by satisfying multi-view consistency constraints from unlabeled multi-view videos without camera calibration, while simultaneously learning representations of multiple plausible pose hypotheses. For this reason, we call our proposed network a Multi-Hypothesis Canonical Lifting Network (MHCanonNet). By enriching the diversity of extracted features and keeping various possibilities open, our network accurately estimates the final 3D pose. The key idea lies in the design of a novel and unbiased reconstruction objective function that combines multiple hypotheses from different viewpoints. The proposed approach demonstrates state-of-the-art results not only on two popular benchmark datasets, Human3.6M and MPI-INF-3DHP but also on an in-the-wild dataset, Ski-Pose, surpassing existing self-supervised training methods. | Kim, Hyun-Woo; Lee, Gun-Hee; Nam, Woo-Jeoung; Jin, Kyung-Min; Kang, Tae-Kyung; Yang, Geon-Jun; Lee, Seong-Whan | Korea Univ, Dept Artificial Intelligence, Anam Dong, Seoul 02841, South Korea; Korea Univ, Dept Comp Sci & Engn, Anam Dong, Seoul 02841, South Korea; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea | 56336378000; 57219703881; 57212464991; 57819311800; 57819313400; 58079093200; 7601390519 | sw.lee@korea.ac.kr; | PATTERN RECOGNITION | PATTERN RECOGN | 0031-3203 | 1873-5142 | 145 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 7.6 | 8.9 | 2.56 | 2025-04-16 | 7 | 9 | 3D human pose; Self-supervised learning; Multi-view geometry | POSE | 3D human pose; Multi-view geometry; Self-supervised learning | Pattern recognition; 3d human pose; 3D human pose estimation; Human pose; Large amounts; Multi-hypothesis; Multi-view geometry; Self-supervised learning; Supervised learning approaches; Supervised trainings; Training methods; Supervised learning | English | 2024 | 2024-01 | 10.1016/j.patcog.2023.109908 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Removal of contaminants of emerging concerns and dyes by MXene-based membranes in water: A review | MXenes are being currently studied extensively in various environmental fields, owing to their unique structures and chemical properties. Particularly, using MXenes as coatings on membranes can effectively remove various contaminants from aquatic environments. However, challenges, such as porosity -selectivity trade-offs and membrane swelling, limit the effectiveness of MXene membranes. To address these limitations, ongoing research is applying various techniques, such as the intercalation of different nanomaterials into MXene nanosheets. Although research on MXene-based membranes is actively progressing, reviews addressing emerging concerns regarding the use of antibiotics and pharmaceuticals as contaminants and dye chemicals are lacking. Accordingly, the objective of this review was to provide a comprehensive overview of recent studies on MXene-based membranes, specifically in the context of removing dye chemicals and contaminants of emerging concern. The review indicated that MXene-based membranes are a promising water/wastewater treatment process. Overall, this review could contribute to the development of MXene-based membrane technologies. | Kim, Yurim; Nam, Seong-Nam; Jung, Bongyeon; Park, Chang Min; Jang, Min; Park, Chanhyuk; Chae, Soryong; Huang, Yi; Jun, Byung-Moon; Yoon, Yeomin | Ewha Womans Univ, Dept Environm Sci & Engn, 52 Ewhayeodae Gil, Seoul 03760, South Korea; Korea Army Acad Yeongcheon, Mil Environm Res Ctr, 495 Hoguk Ro, Yeongcheon Si 38900, Gyeongsangbug D, South Korea; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kwangwoon Univ, Dept Elect Engn, 447-1 Wolgye Dong, Seoul 139701, South Korea; Univ Cincinnati, Dept Chem & Environm Engn, 2901 Woodside Dr, Cincinnati, OH 45221 USA; Univ Edinburgh, Inst Mat & Proc, Sch Engn, Robert Stevenson Rd, Edinburgh EH9 3FB, Scotland; Korea Atom Energy Res Inst KAERI, Radwaste Management Ctr, 111 Daedeok Daero 989beon Gil, Daejeon 34057, South Korea | Yoon, Yeomin/KDP-2253-2024; Park, Chanhyuk/A-2577-2013; Park, Chang Min/CAA-8506-2022; Nam, Seong-Nam/ABT-9415-2022; Jun, Byung-Moon/Y-2134-2019; HUANG, Yi/G-3405-2011; Jang, Min/J-2230-2012; Jang, Min/M-6690-2018 | 59140902300; 57226757907; 57211690823; 57209588953; 36762550700; 56140966600; 35232373000; 55717272000; 55326699900; 7402126688 | jbm9101@kaeri.re.kr;yoony@ewha.ac.kr; | SEPARATION AND PURIFICATION TECHNOLOGY | SEP PURIF TECHNOL | 1383-5866 | 1873-3794 | 351 | SCIE | ENGINEERING, CHEMICAL | 2024 | 9 | 8.9 | 1.35 | 2025-05-07 | 14 | 17 | MXenes; Membrane; Contaminants of emerging concern; Dyes; Water/wastewater purification | LAMELLAR MEMBRANE; DEGRADATION; G-C3N4; NANOFILTRATION; TETRACYCLINE; SEPARATION; NANOSHEETS; COMPOSITE; SYSTEM; FAMILY | Contaminants of emerging concern; Dyes; Membrane; MXenes; Water/wastewater purification | Contamination; Membrane technology; Stripping (dyes); Water treatment; Aquatic environments; Contaminants of emerging concerns; Environmental fields; Membrane swelling; Mxenes; Trade off; Wastewater purification; Wastewater treatment process; Water/wastewater purification; Economic and social effects | English | 2024 | 2024-12-24 | 10.1016/j.seppur.2024.128125 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Removal of selected contaminants of dyes and pharmaceuticals using MXene-based nanoadsorbents: A review | Due to advancements of science and technology with accelerations of urbanization and industrialization, large quantities of wastewater containing various dyes and pharmaceuticals are discharged. The detection of these organic pollutants has become more prominent. Among water treatment technologies for dealing with such organic pollutants, adsorption using MXene-based nanoadsorbents has gradually gained attention as a more competitive method than other technologies. To apply adsorption to actual wastewater treatment, it is essential to have a comprehensive understanding of how MXene-based nanomaterials remove dyes and pharmaceuticals, the mechanisms involved, and the optimal adsorption performance under various experimental conditions. In this review, various characteristics of MXene-based nanoadsorbents, key adsorption mechanisms, water quality conditions, and their combination with other water treatment technologies are extensively discussed. In particular, while previous studies have primarily focused on dyes as the target contaminants, this review also highlights the overall removal mechanisms and adsorption performance of MXene-based adsorbents for various pharmaceuticals. The potential and expected challenges of modified MXene-based adsorbents along with the economic feasibility and regenerability of MXene-based nanoadsorbents are also discussed. | Park, Dahee; Nam, Seong-Nam; Jung, Bongyeon; Choi, Jong Soo; Park, Chang Min; Choong, Choe Earn; Jang, Min; Cho, Kyung-Suk; Jun, Byung-Moon; Yoon, Yeomin | Ewha Womans Univ, Dept Environm Sci & Engn, 52 Ewhayeodae Gil, Seoul 03760, South Korea; Korea Army Acad Yeongcheon, Mil Environm Res Ctr, 495 Hoguk Ro, Yeongcheon Si 38900, Gyeongsangbug D, South Korea; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kwangwoon Univ, Dept Elect Engn, 447-1 Wolgye Dong, Seoul 139701, South Korea; Korea Atom Energy Res Inst KAERI, Radwaste Management Ctr, 111 Daedeok Daero 989beon Gil, Daejeon 34057, South Korea | Nam, Seong-Nam/ABT-9415-2022; Yoon, Yeomin/KDP-2253-2024; Jun, Byung-Moon/Y-2134-2019; Jang, Min/J-2230-2012; Choong, Choe Earn/J-3005-2016; Jang, Min/M-6690-2018; Park, Chang Min/CAA-8506-2022 | 58915945100; 57226757907; 57211690823; 58916237300; 57209588953; 58916095000; 36762550700; 7403957095; 55326699900; 7402126688 | jbm9101@kaeri.re.kr;yoony@ewha.ac.kr; | SEPARATION AND PURIFICATION TECHNOLOGY | SEP PURIF TECHNOL | 1383-5866 | 1873-3794 | 341 | SCIE | ENGINEERING, CHEMICAL | 2024 | 9 | 8.9 | 2.33 | 2025-05-07 | 23 | 24 | MXene; Adsorption; Water purification; Dyes; Pharmaceuticals | 2-DIMENSIONAL TITANIUM CARBIDE; METAL-ORGANIC FRAMEWORKS; CONGO RED-DYE; WASTE-WATER; PHOTOCATALYTIC ACTIVITY; AQUEOUS-SOLUTION; HUMIC-ACID; ADSORPTION; CARBON; NANOCOMPOSITES | Adsorption; Dyes; MXene; Pharmaceuticals; Water purification | Dyes; Organic pollutants; Stripping (dyes); Wastewater treatment; Water pollution; Water quality; Adsorption mechanism; Adsorption performance; Experimental conditions; Industrialisation; Mxene; Nanoadsorbents; Pollutant adsorption; Science and Technology; Water purification; Water treatment technologies; Adsorption | English | 2024 | 2024-08-09 | 10.1016/j.seppur.2024.126864 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Two in one is really better: NiAl-LDH/[CoNi(μ3-tp)2(μ2-py)2] nanocomposite for enhanced antibiotic norfloxacin degradation and H2 evolution reaction | As an astonishing way of dealing with both environmental pollution and the energy crisis, we report the synthesis of a remarkable nanocomposite comprising Co-Ni-based metal-organic framework [CoNi(mu 3-tp)2(mu 2-py)2 or CNTP-MOF] allied with Ni-Al-based layered double hydroxide (NiAl-LDH) via a facile thermal impregnation technique. It showed outstanding degradation of norfloxacin and renewable H2 evolution under simulated solar light irradiation. Notably, the photocatalytic performance of NiAl-LDH/CNTP-MOF nanocomposite was significantly improved compared to its two individual components, reaching a high norfloxacin degradation level of 96 % in 60 min and H2 evolution of around 1914 mu mol g-1 within 5 h of irradiation time. In addition, four successive photocatalytic cycles using the NiAl-LDH/CNTP-MOF nanocomposite revealed that our synthesized material has extremely excellent stability without affecting the morphological structure. Potential reaction routes for norfloxacin degradation and H2 evolution over the most active NiAl-LDH/CNTP-MOF nanocomposite are also discussed in detail, wherein the heterojunction plays a key role in the enhancement of electron-hole pair separation, consequently substantial efficiency. Eventually, this work provides excellent insights for designing and constructing MOF-based nanocomposite with notable photocatalytic performance toward wide-ranging environmental remediation. | Lee, Dong-Eun; Danish, Mohtaram; Jo, Wan-Kuen | Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, 80 Daehak Ro, Daegu 41566, South Korea | Jo, Wan/AAO-5329-2020 | 56605563300; 57216220743; 7103322277 | dmohtaram@gmail.com;wkjo@knu.ac.kr; | SEPARATION AND PURIFICATION TECHNOLOGY | SEP PURIF TECHNOL | 1383-5866 | 1873-3794 | 332 | SCIE | ENGINEERING, CHEMICAL | 2024 | 9 | 8.9 | 3.73 | 2025-05-07 | 20 | 21 | Pharmaceutical compound; Water splitting; Solar light; Layered double hydroxide; Metal-organic framework | PHOTOCATALYTIC H-2 PRODUCTION; GRAPHITIC CARBON NITRIDE; ORGANIC FRAMEWORKS MOFS; HETEROJUNCTION; CONSTRUCTION; PERFORMANCE; EFFICIENT; COMPOSITE; TETRACYCLINE; STRATEGIES | Layered double hydroxide; Metal–organic framework; Pharmaceutical compound; Solar light; Water splitting | English | 2024 | 2024-03-20 | 10.1016/j.seppur.2023.125748 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Comparison of off-target pesticide drift in paddy fields from unmanned aerial vehicle spraying using cellulose deposition sampler | Off-target pesticide drift in paddy fields following unmanned aerial vehicle (UAV) spraying was evaluated using cellulose deposition samplers (CDSs). An analytical method for quantifying ferimzone Z and E isomers deposited on CDSs was developed using LC-MS/MS. The suitability of the CDS method was confirmed by comparing deposition patterns on CDSs with residue levels in rice plant samples. To assess pesticide deposition in paddy fields, CDSs were strategically placed at varying distances from target areas, followed by UAV spraying. The fungicide agrochemicals were applied with and without adjuvants, and wind direction affected the drift trajectory for all treatment groups. Adjuvants, particularly soy lecithin as the major component, significantly enhanced pesticide deposition within the spray pathway while reducing drift rates relatively by 47.9-68.0 %. Higher wind speeds were found to exacerbate drift, but adjuvant-treated sprays showed less variability in deposition patterns under these conditions. Pesticide residues in harvested brown rice were found to be below the maximum residue limits (MRLs), ensuring safety for consumption. These findings highlight the importance of selecting appropriate adjuvants in UAV-based pesticide applications to optimize deposition efficiency and minimize environmental contamination. | Eun, Hye-Ran; Kim, So-Hee; Lee, Yoon-Hee; Kim, Su-Min; Lee, Ye-Jin; Jung, Hee-Young; Min, Yi-Gi; Noh, Hyun Ho; Shin, Yongho | Dong A Univ, Dept Appl Biosci, Busan 49315, South Korea; Natl Inst Agr Sci, Residual Agrochem Assessment Div, Wonju 55365, South Korea; Kyungpook Natl Univ, Dept Plant Med, Daegu 41566, South Korea; Korea Agr Unmanned Aerial Vehicle Assoc, Suwon 16432, South Korea | ; Kim, Sumin/IZE-4757-2023; Shin, Yongho/HKO-5185-2023 | 59169371400; 58222914700; 58222536600; 59169745700; 59169275900; 59510734500; 59335835300; 56531459500; 57206634976 | noh1983@korea.kr;yong6103@dau.ac.kr; | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | ECOTOX ENVIRON SAFE | 0147-6513 | 1090-2414 | 285 | SCIE | ENVIRONMENTAL SCIENCES;TOXICOLOGY | 2024 | 6.1 | 9.0 | 1 | 2025-05-07 | 4 | 4 | Off-target drift; Ferimzone; Unmanned aerial vehicle; Paddy field; Rice; Cellulose deposition sampler | ADJUVANTS; UAV | Cellulose deposition sampler; Ferimzone; Off-target drift; Paddy field; Rice; Unmanned aerial vehicle | Agriculture; Aircraft; Cellulose; Chromatography, Liquid; Environmental Monitoring; Fungicides, Industrial; Oryza; Pesticide Residues; Pesticides; Tandem Mass Spectrometry; Wind; ferimzone E; ferimzone Z; fungicide; unclassified drug; cellulose; fungicide; pesticide; pesticide residue; cellulose; comparative study; fungicide; paddy field; pesticide residue; rice; unmanned vehicle; Article; calibration; high performance liquid chromatography; limit of detection; limit of quantitation; liquid chromatography-mass spectrometry; maximum residue limit; multiple reaction monitoring; nonhuman; off-target effect; off-target pesticide drift; paddy field; pesticide spraying; physical parameters; signal noise ratio; thin layer chromatography; unmanned aerial vehicle; wind speed; agriculture; aircraft; chemistry; comparative study; environmental monitoring; liquid chromatography; Oryza; procedures; tandem mass spectrometry; wind | English | 2024 | 2024-10-15 | 10.1016/j.ecoenv.2024.117075 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Development of an overlaid concrete median barrier: Numerical studies and full-scale field tests | This study aims to develop an overlaid CMB(Concrete Median Barrier) with a containment level of SB5 (230 kJ of impact severity) based on a series of numerical simulations and full-scale field tests. The 810-mm CMB (CMB810) currently in service on roads, should be overlaid up to height of 1370 mm (CMB1370) with containment level of SB5 to prevent vehicles from traveling over it. From a series of numerical simulation, the effects of dowel/ longitudinal bars on structural adequacy and occupant risk were quantitatively assessed in order to develop the CMB1370. Numerical analyses indicate that decreasing the spacing of dowel bars and the proximity of longitudinal bars from the top of the CMB1370 can significantly lessen the volume loss incurred during vehicle-tobarrier collisions. The numerically proposed CMB1370 underwent full-scale field tests in compliance with three evaluation criteria: (1) structural adequacy, (2) occupant risk, (3) vehicle's post-impact trajectory. The fullscale field test results demonstrated that the CMB1370 effectively contained and redirected the vehicle without any instance of damages, penetration or overriding. The measured deformation of CMB1370 by several LVDTs was within acceptable limits for use on the road. Previous full-scale field tests, the primary focus was on the structural adequacy of the CMB and the resulting damage it sustained. However, these findings provide new insights into the behavior and rehabilitation of the CMB, as well as the damage sustained at impact. Moreover, no significantly fragmented debris larger than 2.0 kg was observed from the barrier. Thus, the proposed CMB1370 meets all the requirements specified in the crash test guidelines in Korea. | Jeong, Yoseok; Lee, Ilkeun; Lee, Jaeha; Kim, WooSeok | Kyungpook Natl Univ, Dept Construct & Disaster Prevent Engn, Daegu 37224, Gyeongbuk, South Korea; Expressway & Transportat Res Inst, Construct & Environm Res Grp, 922 Dongbudae Ro, Hwaseong 20896, Gyeonggi Do, South Korea; Korea Maritime & Ocean Univ, Dept Civil Engn, 727 Taejong Ro, Busan 49112, South Korea; Chungnam Natl Univ, Dept Civil Engn, 99 Daehak Ro, Daejeon 34134, South Korea | 54980727300; 55455771300; 57014428600; 56286036900 | wooseok@cnu.ac.kr; | ENGINEERING STRUCTURES | ENG STRUCT | 0141-0296 | 1873-7323 | 315 | SCIE | ENGINEERING, CIVIL | 2024 | 6.4 | 9.0 | 0.34 | 2025-05-07 | 1 | 1 | Overlaid concrete median barrier; Pavement overlay; Impact simulation; Full-scale field test | PERFORMANCE; COLUMNS; RDD | Full-scale field test; Impact simulation; Overlaid concrete median barrier; Pavement overlay | Korea; Automobile testing; Concrete testing; Concretes; Crashworthiness; Numerical models; Containment levels; Dowel bars; Evaluation criteria; Full-scale field tests; Impact simulation; Longitudinal bars; Median barriers; Overlaid concrete median barrier; Post impacts; Volume loss; barrier (equipment); concrete structure; field method; numerical model; pavement; testing method; Risk assessment | English | 2024 | 2024-09-15 | 10.1016/j.engstruct.2024.118469 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Early life exposure to perfluorooctanesulfonate (PFOS) impacts vital biological processes in Xenopus laevis: Integrated morphometric and transcriptomic analyses | Perfluorooctanesulfonate (PFOS) is a ubiquitous environmental pollutant associated with increasing health concerns and environmental hazards. Toxicological analyses of PFOS exposure are hampered by large interspecies variations and limited studies on the mechanistic details of PFOS-induced toxicity. We investigated the effects of PFOS exposure on Xenopus laevis embryos based on the reported developmental effects in zebrafish. X. laevis was selected to further our understanding of interspecies variation in response to PFOS, and we built upon previous studies by including transcriptomics and an assessment of ciliogenic effects. Midblastula-stage X. laevis embryos were exposed to PFOS using the frog embryo teratogenesis assay Xenopus (FETAX). Results showed teratogenic effects of PFOS in a time- and dose-dependent manner. The morphological abnormalities of skeleton deformities, a small head, and a miscoiled gut were associated with changes in gene expression evidenced by whole-mount in situ hybridization and transcriptomics. The transcriptomic profile of PFOS-exposed embryos indicated the perturbation in the expression of genes associated with cell death, and downregulation in adenosine triphosphate (ATP) biosynthesis. Moreover, we observed the effects of PFOS exposure on cilia development as a reduction in the number of multiciliated cells and changes in the directionality and velocity of the cilia-driven flow. Collectively, these data broaden the molecular understanding of PFOS-induced developmental effects, whereby ciliary dysfunction and disrupted ATP synthesis are implicated as the probable modes of action of embryotoxicity. Furthermore, our findings present a new challenge to understand the links between PFOS-induced developmental toxicity and vital biological processes. | Ismail, Tayaba; Lee, Hyun-Kyung; Lee, Hongchan; Kim, Youni; Kim, Eunjeong; Lee, Jun-Yeong; Kim, Kee-Beom; Ryu, Hong-Yeoul; Cho, Dong-Hyung; Kwon, Taeg Kyu; Park, Tae Joo; Kwon, Taejoon; Lee, Hyun-Shik | Kyungpook Natl Univ, Sch Life Sci, Coll Nat Sci,KNU LAMP Res Ctr,KNU Inst Basic Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Keimyung Univ, Dept Immunol, Sch Med, Daegu 42601, South Korea; Ulsan Natl Inst Sci & Technol, Coll Informat Bioconvergence, Dept Biol Sci, Ulsan 44919, South Korea; Ulsan Natl Inst Sci & Technol, Dept Biomed Engn, Coll Informat Bioconvergence, Ulsan 44919, South Korea | Park, Tae Joo/G-1460-2011; Choi, Hye Rin/JDV-9065-2023; Ismail, Tayaba/LPQ-9181-2024; Kwon, Taejoon/S-3835-2016 | 57190277495; 57221571155; 57210948333; 57204943696; 56892981600; 56428518900; 58136893800; 55889917800; 35093684400; 7202206057; 58254025900; 35484365800; 16316010200 | leeh@knu.ac.kr; | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | ECOTOX ENVIRON SAFE | 0147-6513 | 1090-2414 | 269 | SCIE | ENVIRONMENTAL SCIENCES;TOXICOLOGY | 2024 | 6.1 | 9.0 | 1.11 | 2025-04-16 | 3 | 3 | PFOS; Bioenergetics; Ciliogenesis; Embryotoxicity; Transcriptomics; Xenopus | SULFONATE PFOS; ACID PFOS; PERFLUOROALKYL SUBSTANCES; PERFLUORINATED COMPOUNDS; ZEBRAFISH; TOXICITY; CILIA; ASSAY; RISK | Bioenergetics; Ciliogenesis; Embryotoxicity; PFOS; Transcriptomics; Xenopus | Adenosine Triphosphate; Alkanesulfonic Acids; Animals; Embryo, Nonmammalian; Fluorocarbons; Gene Expression Profiling; Teratogens; Xenopus laevis; Zebrafish; adenosine triphosphate; perfluorooctanesulfonic acid; adenosine triphosphate; alkanesulfonic acid; fluorocarbon; perfluorooctanesulfonic acid; teratogenic agent; abnormality; bioenergetics; biological development; embryo; frog; gene expression; morphometry; surfactant; toxicity; animal cell; animal experiment; animal model; Article; assay; bioenergy; biological activity; biosynthesis; blastula; bone malformation; cell count; cell death; chemical teratogenesis; cilium; developmental stage; developmental toxicity; down regulation; embryo; embryotoxicity; enteropathy; environmental exposure; female; gene expression; in situ hybridization; morphometry; mouse; nonhuman; teratogenicity; time factor; toxic concentration; transcriptomics; velocity; Xenopus; Xenopus laevis; animal; gene expression profiling; genetics; nonmammalian embryo; Xenopus laevis; zebra fish | English | 2024 | 2024-01-01 | 10.1016/j.ecoenv.2023.115820 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Enhanced use of chemical fertilizers and mitigation of heavy metal toxicity using biochar and the soil fungus Bipolaris maydis AF7 in rice: Genomic and metabolomic perspectives | Chemical fertilizers are the primary source of crop nutrition; however, their increasing rate of application has created environmental hazards, such as heavy metal toxicity and eutrophication. The synchronized use of chemical fertilizers and eco-friendly biological tools, such as microorganisms and biochar, may provide an efficient foundation to promote sustainable agriculture. Therefore, the current study aimed to optimize the nutrient uptake using an inorganic fertilizer, sulfate of potash (SOP) from the plant growth-promoting fungus Bipolaris maydis AF7, and biochar under heavy metal toxicity conditions in rice. Bioassay analysis showed that AF7 has high resistance to heavy metals and a tendency to produce gibberellin, colonize the fertilizer, and increase the intake of free amino acids. In the plant experiment, the co-application of AF7 +Biochar+MNF+SOP significantly lowered the heavy metal toxicity, enhanced the nutrient uptake in the rice shoots, and improved the morphological attributes (total biomass). Moreover, the co-application augmented the glucose and sucrose levels, whereas it significantly lowered the endogenous phytohormone levels (salicylic acid and jasmonic acid) in the rice shoots. The increase in nutrient content aligns with the higher expression of the OsLSi6, PHT1, and OsHKT1 genes. The plant growth traits and heavy metal tolerance of AF7 were validated by whole-genome sequencing that showed the presence of the heavy metal tolerance and detoxification protein, siderophore iron transporter, Gibberellin cluster GA4 desaturase, and DES₁ genes, as well as others that regulate glucose, antioxidants, and amino acids. Because the AF7 +biochar+inorganic fertilizer works synergistically, nutrient availability to the crops could be improved, and heavy metal toxicity and environmental hazards could be minimized. | Adhikari, Arjun; Kwon, Eun-Hae; Khan, Muhammad Aaqil; Shaffique, Shifa; Kang, Sang-Mo; Lee, In-Jung | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | Khan, Muhammad/ABB-9797-2021; Lee, In-Jung/GLS-0432-2022; shaffique, shifa/KUC-7102-2024; Adhikari, Arjun/JCO-3306-2023; Kang, Sang-Mo/MBG-7823-2025; Adhikari, Arjun/AAV-6297-2021 | 57195601415; 57224398710; 57188585606; 57203898867; 56189696900; 16425830900 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | ECOTOX ENVIRON SAFE | 0147-6513 | 1090-2414 | 271 | SCIE | ENVIRONMENTAL SCIENCES;TOXICOLOGY | 2024 | 6.1 | 9.0 | 4.48 | 2025-05-07 | 10 | 10 | Environment; Microorganisms; Nutrients; Pollution; Stress; Sustainable agriculture | ARBUSCULAR MYCORRHIZAL FUNGI; SOLUBLE SUGARS; SALICYLIC-ACID; JASMONIC ACID; FOOD; CADMIUM; STRESS; RESPONSES; GROWTH; PLANTS | Environment; Microorganisms; Nutrients; Pollution; Stress; Sustainable agriculture | Amino Acids; Bipolaris; Bipolaris maydis; Charcoal; Fertilizers; Fungi; Genomics; Gibberellins; Glucose; Metals, Heavy; Oryza; Soil; amino acid; antioxidant; cadmium; charcoal; chromium; fertilizer; gibberellin; glucose; jasmonic acid; nickel; salicylic acid; sucrose; amino acid; charcoal; fertilizer; gibberellin; glucose; heavy metal; alternative agriculture; fertilizer application; fungus; genomics; heavy metal; metabolism; nutrient uptake; pollution; rice; soil microorganism; toxicity; amino acid intake; Article; bioassay; biomass; Cochliobolus heterostrophus; controlled study; gene expression; genomics; metabolomics; nonhuman; phytotoxicity; plant gene; plant growth; rice; shoot; toxicity; validation process; whole genome sequencing; Bipolaris; chemistry; Cochliobolus heterostrophus; fungus; genetics; Oryza; soil | English | 2024 | 2024-02 | 10.1016/j.ecoenv.2024.115938 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Evaluation of Dynamic Light Scattering as an Effective Quality Control Method for Aggregates in Radiolabeled Antibodies | Radiolabeled antibodies are promising for targeted cancer imaging, but their structural integrity may suffer during bioconjugation and radiolabeling, leading to undetected aggregation. This study evaluates dynamic light scattering (DLS) as a complementary method to size-exclusion high-performance liquid chromatography (SEC-HPLC) for detecting aggregation in radiolabeled antibodies. Trastuzumab was conjugated with a NOTA bifunctional chelator at various ratios, radiolabeled with [64Cu]CuCl2, and analyzed by using DLS and SEC-HPLC before and after purification. DLS revealed significant aggregation during preparation, undetected by SEC-HPLC, and showed reduced aggregates following purification. Tumor-targeting efficacy correlated with intact antibody content, with Pearson's correlations of 0.71 (PET imaging) and 0.75 (biodistribution) in NIH3T6.7 tumor-bearing mice. The findings suggest DLS as a vital quality control tool, offering enhanced detection of antibody aggregation. By adopting DLS, the bioactivity of radiolabeled antibodies can be better predicted, potentially improving the reliability and effectiveness of these radiopharmaceuticals in clinical settings. | Nguyen, Huu Bao; Park, Hyun; Lim, Jeong Eun; Nguyen, Thuy Tien; Kim, Hwan Hui; Kim, Kyeongwon; Kim, Jung Young; Lee, Kyo Chul; Yoo, Jeongsoo | Kyungpook Natl Univ, Sch Med, Program Biomed Sci Creat Future Talents, Dept Mol Med,Brain Korea 21 Four KNU Convergence E, Daegu 41944, South Korea; Korea Inst Radiol & Med Sci, Div Appl RI, Seoul 01812, South Korea | yooj@knu.ac.kr; | JOURNAL OF MEDICINAL CHEMISTRY | J MED CHEM | 0022-2623 | 1520-4804 | 68 | 1 | SCIE | CHEMISTRY, MEDICINAL | 2024 | 6.8 | 9.0 | 0 | STABILITY; RADIOMETALS | English | 2024 | 2024-12-16 | 10.1021/acs.jmedchem.4c02344 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | G Protein-Coupled Estrogen Receptor-Mediated Anti-Inflammatory and Mucosal Healing Activity of a Trimethylpyridinol Analogue in Inflammatory Bowel Disease | Inflammatory bowel disease (IBD) is characterized by abnormal immune responses, including elevated proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6) in the gastrointestinal (GI) tract. This study presents the synthesis and anti-inflammatory evaluation of 2,4,5-trimethylpyridin-3-ol analogues, which exhibit dual inhibition of TNF alpha- and IL-6-induced inflammation. Analysis using in silico methods, including 3D shape-based target identification, modeling, and docking, identified G protein-coupled estrogen receptor 1 (GPER) as the molecular target for the most effective analogue, 6-26, which exhibits remarkable efficacy in ameliorating inflammation and restoring colonic mucosal integrity. This was further validated by surface plasmon resonance (SPR) assay results, which showed direct binding to GPER, and by the results showing that GPER knockdown abolished the inhibitory effects of 6-26 on TNF alpha and IL-6 actions. Notably, 6-26 displayed no cytotoxicity, unlike G1 and G15, a well-known GPER agonist and an antagonist, respectively, which induced necroptosis independently of GPER. These findings suggest that the GPER-selective compound 6-26 holds promise as a therapeutic candidate for IBD. | Awasthi, Bhuwan Prasad; Chaudhary, Prakash; Lim, Dongchul; Yadav, Kiran; Lee, Iyn-Hyang; Banskota, Suhrid; Chaudhary, Chhabi Lal; Karmacharya, Ujjwala; Lee, Jiwoo; Im, So Myoung; Nam, Yeonju; Eun, Ji Won; Lee, Sungeun; Lee, Ji-Min; Kim, Eun Soo; Ryou, Chongsuk; Kim, Tae Hun; Park, Hee Dong; Kim, Jung-Ae; Nam, Tae-gyu; Jeong, Byeong-Seon | Yeungnam Univ, Inst Drug Res, Coll Pharm, Gyongsan 38541, South Korea; Yeungnam Univ, Inst Drug Res, Gyongsan 38541, South Korea; Innovo Therapeut Inc, Daejeon 34013, South Korea; Hanyang Univ, Inst Pharmaceut Sci & Technol, Ansan 15588, Gyeonggi Do, South Korea; Gyeonggido Business & Sci Accelerator, Bio Ind Dept, Suwon 16229, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea | Yadav, Kiran/AGH-1742-2022; Kim, Sang/J-5398-2012; Awasthi, Bhuwan Prasad/MAH-8562-2025; Banskota, Suhrid/Q-8485-2016; Banskota, Suhrid/AAF-2315-2020; Lee, Ji Min/KCZ-2783-2024; Lee, SangHun/GPW-6306-2022 | 57222337395; 57203412971; 57222335755; 58918817400; 54780158300; 55549918500; 57189520266; 57191042671; 59196651900; 58036102500; 58332234900; 59195605200; 57205261997; 57211862625; 57203086704; 6602708620; 59196859500; 57222339366; 7601363878; 8435892100; 34975054400 | jakim@yu.ac.kr;tnam@hanyang.ac.kr;jeongb@ynu.ac.kr; | JOURNAL OF MEDICINAL CHEMISTRY | J MED CHEM | 0022-2623 | 1520-4804 | 67 | 13 | SCIE | CHEMISTRY, MEDICINAL | 2024 | 6.8 | 9.0 | 0.47 | 2025-05-07 | 2 | 2 | NF-KAPPA-B; GROWTH-FACTOR RECEPTOR; BREAST-CANCER CELLS; THERAPEUTIC TARGETS; T-CELLS; GPER; DERIVATIVES; MIGRATION; GPR30; 6-AMINO-2,4,5-TRIMETHYLPYRIDIN-3-OLS | Animals; Anti-Inflammatory Agents; Humans; Inflammatory Bowel Diseases; Interleukin-6; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Pyridines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; 2,4,5 trimethylpyridin 3 ol derivative; 3 chloro 6 fluoro n (5 hydroxy 3,4,6 trimethylpyridin 2 yl)benzo[b]thiophene 2 carboxamide; estrogen receptor; G protein coupled receptor; interleukin 6; pyridinol; tumor necrosis factor; unclassified drug; antiinflammatory agent; estrogen receptor; G protein coupled receptor; GPER1 protein, human; pyridine derivative; agonist; animal cell; animal experiment; animal model; antiinflammatory activity; Article; colon mucosa; computer model; controlled study; cytotoxicity; drug efficacy; drug receptor binding; drug selectivity; drug synthesis; healing; human; human cell; immune response; inflammatory bowel disease; molecular docking; mouse; necroptosis; nonhuman; structure activity relation; surface plasmon resonance; animal; C57BL mouse; chemistry; drug effect; drug therapy; inflammatory bowel disease; intestine mucosa; metabolism; pathology; synthesis | English | 2024 | 2024-06-19 | 10.1021/acs.jmedchem.3c02458 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Prenatal to peripubertal exposure to Di(2-ethylhexyl) phthalate induced endometrial atrophy and fibrosis in female mice | Di(2-ethylhexy) phthalate (DEHP) is a widely used plasticizer that is ubiquitously found in the environment. Using a mouse model, we investigated the impact of early life DEHP exposure ranging from the prenatal to peripubertal developmental period of the female reproductive system. Pregnant female mice were allocated to three groups as follows: control, 100 mg/kg/day, and 500 mg/kg/day DEHP treatment. DEHP exposure was introduced through feeding during pregnancy (3 weeks) and lactation (3 weeks). After weaning, the offspring were also exposed to DEHP through feeding for another 2 weeks. Observations were conducted on female offspring at 10 and 24 weeks. The number of live offspring per dam was significantly lower in the high-DEHP-exposed group (500 mg/kg/day) compared to the control group (7.67 +/- 1.24 vs. 14.17 +/- 0.31; p < 0.05) despite no difference in pregnancy rates across the groups. Low-DEHP exposure (100 mg/kg/day) resulted to a decreased body weight (36.07 +/- 3.78 vs. 50.11 +/- 2.11 g; p < 0.05) and decreased left uterine length (10.60 +/- 1.34 vs. 14.77 +/- 0.82 mm; p < 0.05) in 24-week- old female mice. As early as 10 weeks, endometrial atrophy and fibrosis were observed, and endometrial cystic hyperplasia was noted in female mice at 24 weeks. Our study is the first to demonstrate that female mice exposed to DEHP in the early life developed endometrial fibrosis in the female offspring. Further studies on the consequences of these observations in fecundity and other reproductive functions are warranted. | Lee, Jisun; Chang, Sun Hee; Cho, Yoon Hee; Kim, Jin Su; Kim, Hyeongi; Zaheer, Javeria; Lee, Gowoon; Choi, Kyungho; Yoon, Yeong Sook; Kim, Young Ah | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Obstet & Gynecol, Daegu 41944, South Korea; Inje Univ Ilsan Paik Hosp, Dept Pathol, Gyeonggi-do 10380, Goyang, South Korea; Univ Montana, Dept Biomed Pharmaceut Sci, Missoula, MT 59812 USA; Korea Inst Radiol & Med Sci KIRAMS, Div Appl RI, Seoul 01812, South Korea; Seoul Natl Univ, Sch Publ Hlth, Dept Environm Hlth Sci, Seoul 08826, South Korea; Inje Univ Ilsan Paik Hosp, Ctr Hlth Promot, Dept Family Med, Goyang Si, Gyeonggi Do 10380, South Korea; Inje Univ Ilsan Paik Hosp, Dept Obstet & Gynecol, Goyang Si, Gyeonggi Do 10380, South Korea; Inje Univ Ilsan Paik Hosp, Dept Obstet & Gynecol, 170 Joohwa Ro, Goyang Si 10380, Gyeonggi Do, Brazil | Kim, Jinsu/ADX-7780-2022; Cho, Yoon/AAN-6560-2021; Lee, Gowoon/IUP-5303-2023; choi, kyungho/D-5732-2012 | 57216463710; 23491296800; 55472222600; 13409877300; 57187828600; 57209507353; 55656664700; 35217582900; 8659033200; 57205628180 | camanbal@paik.ac.kr; | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | ECOTOX ENVIRON SAFE | 0147-6513 | 1090-2414 | 269 | SCIE | ENVIRONMENTAL SCIENCES;TOXICOLOGY | 2024 | 6.1 | 9.0 | 1.66 | 2025-04-16 | 3 | 4 | Di(2-ethiylhexy) phthalate; Prenatal to peripubertal exposure; Body weight; Endometrial atrophy; Fibrosis; Endometrial cystic hyperplasia | PERINATAL EXPOSURE; IN-UTERO; RECEPTOR; GROWTH; DEHP; METABOLITES; IMPAIRS; URINARY; OVARY; BETA | Body weight; Di(2-ethiylhexy) phthalate; Endometrial atrophy; Endometrial cystic hyperplasia; Fibrosis; Prenatal to peripubertal exposure | Diethylhexyl Phthalate; Female; Fibrosis; Humans; Phthalic Acids; Pregnancy; Prenatal Exposure Delayed Effects; phthalic acid bis(2 ethylhexyl) ester; phthalic acid; phthalic acid bis(2 ethylhexyl) ester; phthalic acid derivative; developmental stage; female; phthalate; pollution exposure; reproduction; rodent; weight; animal experiment; animal tissue; Article; body weight; controlled study; endometrium atrophy; female; histopathology; hyperplasia; lactation; male; mouse; nonhuman; pregnancy; pregnancy outcome; pregnant woman; prenatal exposure; reproduction; fibrosis; human | English | 2024 | 2024-01-01 | 10.1016/j.ecoenv.2023.115798 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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