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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article Ultrahigh-Speed Spectral-Domain Optical Coherence Tomography up to 1-MHz A-Scan Rate Using Space-Time-Division Multiplexing The primary optimization of the imaging speed of optical coherence tomography (OCT) has been keenly studied. In order to overcome the major speed limitation of spectral-domain OCT (SD-OCT), we developed an ultrahigh-speed SD-OCT system, with an A-scan rate of up to 1 MHz, using the method of space-time-division multiplexing (STDM). Multicameras comprising a single spectrometer were implemented in the developed ultrahigh-speed STDM method to eliminate the dead time of operation, whereas STDM was simultaneously employed to enable wide-range scanning measurements at a high speed. By successfully integrating the developed STDM method with GPU parallel processing, 8 vol/s for an image range of 250 x 250 x 2048 pixels (9 x 4.5 x 5 mm) was achieved, with an adjustable volume rate according to the required scanning speed and range. The examined STDM-OCT results of the customized optical thin film confirmed its feasibility for various fields that require rapid and wide-field scanning. Seong, Daewoon; Jeon, Deokmin; Wijesinghe, Ruchire Eranga; Park, Kibeom; Kim, Hyeree; Lee, Euimin; Jeon, Mansik; Kim, Jeehyun Kyungpook Natl Univ, Coll IT Engn, Sch Elect & Elect Engn, Daegu 41566, South Korea; Univ Sri Jayewardenepura, Fac Technol, Dept Mat & Mech Technol, Homagama 10200, Sri Lanka; Ulsan Natl Inst Sci & Technol, Dept Biomed Engn, Ulsan 44919, South Korea ; Wijesinghe, Ruchire/K-3797-2016; Park, Kibeom/ABE-3860-2020 57212512353; 57204570554; 56018152300; 56017776400; 57209102795; 57223052911; 24171094000; 7601373350 smc7095@knu.ac.kr;dmjeon@knu.ac.kr;erangawijesinghe@sjp.ac.lk;pepl116@unist.ac.kr;augustmini@knu.ac.kr;hleeworld@gmail.com;msjeon@knu.ac.kr;jeehk@knu.ac.kr; IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT IEEE T INSTRUM MEAS 0018-9456 1557-9662 70 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION 2021 5.332 14.8 1.56 2025-07-30 22 22 Fourier optical signal processing; parallel processing; space-time-division multiplexing (STDM); spectral-domain optical coherence tomography (OCT); ultrahigh-speed imaging system SUBSURFACE DEFECT DETECTION; SWEPT SOURCE; OCT Fourier optical signal processing; parallel processing; space-time-division multiplexing (STDM); spectral-domain optical coherence tomography (OCT); ultrahigh-speed imaging system Coherent light; Scanning; Speed; Strain measurement; Time division multiplexing; Tomography; Imaging speed; Optical thin films; Parallel processing; Range scanning; Scanning speed; Spectral domain OCT; Spectral domain optical coherence tomographies; Ultra high speed; Optical tomography English 2021 2021 10.1109/tim.2021.3073701 바로가기 바로가기 바로가기 바로가기
Article Vitamin C Deficiency Inhibits Nonalcoholic Fatty Liver Disease Progression through Impaired de Novo Lipogenesis Despite the increasing clinical importance of nonalcoholic fatty liver disease (NAFLD), little is known about its underlying pathogenesis or specific treatment. The senescence marker protein 30 (SMP30), which regulates the biosynthesis of vitamin C (VC) in many mammals, except primates and humans, was recently recognized as a gluconolactonase. However, the precise relation between VC and lipid metabolism in NAFLD is not completely understood. Therefore, this study aimed to clearly reveal the role of VC in NAFLD progression. SMP30 knockout (KO) mice were used as a VC-deficient mouse model. To investigate the precise role of VC on lipid metabolism, 13- to 15-week-old SMP30 KO mice and wild-type mice fed a 60% high-fat diet were exposed to tap water or VC-containing water (1.5 g/L) ad libitum for 11 weeks. Primary mouse hepatocytes isolated from the SMP30 KO and wild-type mice were used to demonstrate the relation between VC and lipid metabolism in hepatocytes. Long-term VC deficiency significantly suppressed the progression of simple steatosis. The high-fat diet-fed VC-deficient SMP30 KO mice exhibited impaired sterol regulatory element-binding protein-1c activation because of excessive cholesterol accumulation in hepatocytes. Long-term VC deficiency inhibits de novo Lipogenesis through impaired sterol regulatory element-binding protein-1c activation. Lee, Seoung-Woo; Baek, Su-Min; Kang, Kyung-Ku; Lee, A-Rang; Kim, Tae-Un; Choi, Seong-Kyoon; Roh, Yoon-Seok; Hong, Il-Hwa; Park, Sang-Joon; Kim, Tae-Hwan; Jeong, Kyu-Shik; Park, Jin-Kyu Kyungpook Natl Univ, Coll Vet Med, Dept Vet Pathol, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Histol, Daegu, South Korea; Kyungpook Natl Univ, Stem Cell Therapeut Res Inst, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Core Prot Resources Ctr, Daegu, South Korea; Chungbuk Natl Univ, Coll Pharm, Cheongju, South Korea; Gyeongsang Natl Univ, Coll Vet Med, Dept Vet Pathol, Jinju, South Korea Jeong, Kyu-Shik/D-6740-2011 57218827581; 57207938426; 57215079376; 57207928983; 57214091908; 55505432500; 57208037673; 8702273100; 7501825941; 57202984578; 7201556460; 35213723500 jinkyu820@knu.ac.kr; AMERICAN JOURNAL OF PATHOLOGY AM J PATHOL 0002-9440 1525-2191 191 9 SCIE PATHOLOGY 2021 5.77 14.9 2.59 2025-07-30 19 19 HEPATIC STEATOSIS; GENE-EXPRESSION; CHOLESTEROL; MICE; NAFLD; ACID; SUPPLEMENTATION; BIOSYNTHESIS; EPIDEMIOLOGY; ANTIOXIDANT Animals; Ascorbic Acid Deficiency; Disease Progression; Hepatocytes; Lipid Metabolism; Lipogenesis; Male; Mice; Mice, Knockout; Non-alcoholic Fatty Liver Disease; alanine aminotransferase; ascorbic acid; bile acid; cholesterol; fatty acid; regucalcin; tap water; triacylglycerol; animal cell; animal experiment; animal model; animal tissue; Article; ascorbic acid deficiency; body weight gain; cell culture; controlled study; disease exacerbation; gene knockout; histopathology; immunoblotting; immunofluorescence assay; immunohistochemistry; lipid metabolism; lipogenesis; lipolysis; liver cell; liver weight; male; mouse; nonalcoholic fatty liver; Nonalcoholic Fatty Liver Disease Activity Score; nonhuman; protein expression; real time polymerase chain reaction; staining; steatosis; vitamin supplementation; animal; ascorbic acid deficiency; disease exacerbation; knockout mouse; lipogenesis; metabolism; nonalcoholic fatty liver; physiology English 2021 2021-09 10.1016/j.ajpath.2021.05.020 바로가기 바로가기 바로가기 바로가기
Article Temperature changes around interface cells in a one-dimensional Stefan condensation problem using four well-known phase-change models Discontinuous changes in thermodynamic properties across a very thin-phase interface and irregular deformations in the interfacial shape are accompanied by phase changes. Therefore, to simulate the phase-change phenomenon with a finite-sized mesh system is very challenging. Various numerical phase-change models have been developed, and several of them have been embedded in commercial computational fluid dynamics codes. However, the temperature reproducibility has not been dealt with carefully. In this study, we focused on the fact that most of the numerical phase-change models treat phase changes from a volumetric perspective, even though the phase change is definitely an interfacial phenomenon. We solved the one-dimensional (1D) Stefan condensation problem using four well-known numerical phase-change models (two temperature-difference phase change models and two heat-flux phase-change models). Since the 1D Stefan problem has no convective effects, it is appropriate for investigating the inherent features of models exclusively. The temperature changes and interface movement with time were compared according to the applied phase-change model. Non-physical stepwise temperature changes over time were observed in models based on a volumetric perspective. The error analysis for different grid and time-step sizes was presented for the four different phase-change models. Son, Jong Hyeon; Park, Il Seouk Kyungpook Natl Univ, Sch Mech Engn, 80 Daehakro, Daegu 41566, South Korea 55156951300; 50262800000 einstein@knu.ac.kr; INTERNATIONAL JOURNAL OF THERMAL SCIENCES INT J THERM SCI 1290-0729 1778-4166 161 SCIE ENGINEERING, MECHANICAL;THERMODYNAMICS 2021 4.779 15.0 0.62 2025-07-30 8 12 Phase-change heat transfer; Phase-change model; Stefan problem; Volume of fluid (VOF) HEAT-TRANSFER; MASS-TRANSFER; NUMERICAL-SIMULATION; CORE PHENOMENON; PRESSURE-DROP; VOF METHOD; FILM FLOW; FLUID; SMOOTH; VOLUME Phase-change heat transfer; Phase-change model; Stefan problem; Volume of fluid (VOF) Computational fluid dynamics; Condensation; Cutting; Heat flux; One dimensional; Phase interfaces; Temperature; Computational Fluid Dynamics codes; Condensation problems; Convective effects; Interface movement; Interfacial phenomena; Phase change phenomena; Temperature changes; Temperature differences; Numerical models English 2021 2021-03 10.1016/j.ijthermalsci.2020.106718 바로가기 바로가기 바로가기 바로가기
Article Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp. Five new bicyclic carboxylic acids were obtained by antibacterial activity-guided isolation from a Korean colonial tunicate Didemnum sp. Their structures were elucidated by the interpretation of NMR, MS and CD spectroscopic data. They all belong to the class of aplidic acids. Three of them were amide derivatives (1-3), and the other two were dicarboxylic derivatives (4 and 5). The absolute configurations were determined by a bisignate pattern of CD spectroscopy, which revealed that the absolute configurations of amides were opposite to those of dicarboxylates at every stereogenic centers. Compound 2 exhibited the most potent antibacterial activity (MIC, 2 mu g/mL). Kim, Hiyoung; Lee, Tae Gu; Yang, Inho; Wang, Weihong; Chin, Jungwook; Lee, Jusung; Rho, Boon Jo; Choi, Hyukjae; Nam, Sang-Jip; Hahn, Dongyup; Kang, Heonjoong Seoul Natl Univ, Sch Earth & Environm Sci, Lab Marine Drugs, NS-80, Seoul 08826, South Korea; Konkuk Univ, Dept Biomed Sci & Engn, Seoul 05029, South Korea; FarmHannong Co Ltd, Crop Protect Res Inst, Safety Res Team, Nonsan 33010, South Korea; Korea Maritime & Ocean Univ, Dept Convergence Study Ocean Sci & Technol, Busan 49112, South Korea; Seoul Natl Univ, Res Inst Oceanog, Seoul 08826, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea; Ewha Womans Univ, Nat Hist Museum, Seoul 03760, South Korea; Yeungnam Univ, Coll Pharm, Gyongsan 38541, South Korea; Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Seoul Natl Univ, Interdisciplinary Grad Program Genet Engn, NS-80, Seoul 08826, South Korea ; Chin, Jungwook/E-7611-2013 55661144100; 57204307460; 55601041400; 55355129000; 36554007700; 57192927454; 7006330628; 7404339587; 57208839798; 36554163400; 7404070913 reihyoung@konkuk.ac.kr;leetg@farmhannong.com;ihyang@kmou.ac.kr;pharmacy2007@naver.com;jwchin@dgmif.re.kr;leejusung@snu.ac.kr;nhm@ewha.ac.kr;h5choi@yu.ac.kr;sjnam@ewha.ac.kr;dohahn@knu.ac.kr;hjkang@snu.ac.kr; MARINE DRUGS MAR DRUGS 1660-3397 19 9 SCIE CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY 2021 6.085 15.1 0.09 2025-07-30 0 1 Didemnum; antibacterial; colonial tunicate; bicyclic fatty acids BACTERIAL BIOSYNTHESIS; IDENTIFICATION; ANTIBIOTICS; ALKALOIDS Antibacterial; Bicyclic fatty acids; Colonial tunicate; Didemnum Animals; Anti-Bacterial Agents; Fatty Acids; Molecular Structure; Staphylococcus aureus; Urochordata; amide; antiinfective agent; aplidic acid; bicyclic fatty acid; carboxylic acid; daptomycin; dicarboxylic acid; linezolid; natural product; unclassified drug; vancomycin; antiinfective agent; fatty acid; antibacterial activity; Article; circular dichroism; controlled study; Didemnum; drug isolation; drug structure; mass spectrometry; minimum inhibitory concentration; nonhuman; nuclear magnetic resonance spectroscopy; South Korea; Urochordata; animal; chemical structure; chemistry; drug effect; Staphylococcus aureus; Urochordata English 2021 2021-09 10.3390/md19090521 바로가기 바로가기 바로가기 바로가기
Article Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell The proteolytic processing of amyloid precursor protein (APP) by beta-secretase (BACE1) and gamma-secretase releases amyloid-beta peptide (A beta), which deposits in amyloid plaques and contributes to the initial causative events of Alzheimer's disease (AD). In the present study, the regulatory mechanism of APP processing of three phlorotannins was elucidated in Swedish mutant APP overexpressed N2a (SweAPP N2a) cells. Among the tested compounds, dieckol exhibited the highest inhibitory effect on both intra- and extracellular A beta accumulation. In addition, dieckol regulated the APP processing enzymes, such as alpha-secretase (ADAM10), beta-secretase, and gamma-secretase, presenilin-1 (PS1), and their proteolytic products, sAPP alpha and sAPP beta, implying that the compound acts on both the amyloidogenic and non-amyloidogenic pathways. In addition, dieckol increased the phosphorylation of protein kinase B (Akt) at Ser473 and GSK-3 beta at Ser9, suggesting dieckol induced the activation of Akt, which phosphorylated GSK-3 beta. The specific phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 triggered GSK-3 beta activation and A beta expression. In addition, co-treatment with LY294002 noticeably blocked the effect of dieckol on A beta production, demonstrating that dieckol promoted the PI3K/Akt signaling pathway, which in turn inactivated GSK-3 beta, resulting in the reduction in A beta levels. Yoon, Jeong-Hyun; Lee, Nayoung; Youn, Kumju; Jo, Mi Ra; Kim, Hyeung-Rak; Lee, Dong-Seok; Ho, Chi-Tang; Jun, Mira Dong A Univ, Dept Hlth Sci, Grad Sch, Busan 49315, South Korea; Dong A Univ, Dept Food Sci & Nutr, Busan 49315, South Korea; Natl Inst Fisheries Sci, Div Food Safety & Proc Res, Busan 46083, South Korea; Pukyong Natl Univ, Dept Food Sci & Nutr, Busan 48513, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Daegu 41566, South Korea; Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA Ho, Chi-Tang/B-5629-2012 56427057600; 57219295054; 55072704400; 56193063400; 57213181805; 57210068061; 56510763200; 16230761800 yjhyun1110@donga.ac.kr;nylee0420@donga.ac.kr;kjyoun@dau.ac.kr;mirajo@korea.kr;hrkim@pknu.ac.kr;lee1@knu.ac.kr;ctho@sebs.rutgers.edu;mjun@dau.ac.kr; MARINE DRUGS MAR DRUGS 1660-3397 19 3 SCIE CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY 2021 6.085 15.1 2.28 2025-07-30 26 29 Alzheimer’ s disease; amyloid-beta peptide; GSK-3β dieckol; SweAPP N2a GLYCOGEN-SYNTHASE KINASE-3; AMYLOID PRECURSOR PROTEIN; ECKLONIA-CAVA; ALZHEIMERS-DISEASE; MOUSE MODEL; SYNAPTIC DYSFUNCTION; OXIDATIVE STRESS; PHLOROTANNINS; TAU; AGGREGATION Alzheimer’s disease; amyloid-beta peptide; dieckol; GSK-3β; SweAPP N2a Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzofurans; Cell Line; Chromones; Glycogen Synthase Kinase 3 beta; Mice; Morpholines; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Signal Transduction; Tannins; ADAM10 endopeptidase; amyloid beta protein; amyloid precursor protein; beta secretase; beta secretase inhibitor; central nervous system agents; dieckol; gamma secretase; glycogen synthase kinase 3beta; phosphatidylinositol 3 kinase; presenilin 1; protein kinase B; unclassified drug; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; amyloid beta protein; amyloid precursor protein; benzofuran derivative; chromone derivative; dieckol; glycogen synthase kinase 3beta; morpholine derivative; phosphatidylinositol 3 kinase; protein kinase B; tannin derivative; Article; controlled study; drug efficacy; drug structure; enzyme activation; enzyme inactivation; enzyme regulation; human; Neuro-2a cell line; Pi3K/Akt signaling; protein degradation; protein expression; protein phosphorylation; protein processing; protein synthesis; Alzheimer disease; animal; cell line; comparative study; drug effect; metabolism; mouse; pathophysiology; signal transduction English 2021 2021-03 10.3390/md19030152 바로가기 바로가기 바로가기 바로가기
Article Effective Response to a Regional Outbreak of COVID-19: Experience of a Tertiary Emergency Center Objective: This study evaluates the usefulness, safety, and outcomes of operating a pretriage screening clinic and an expanded preemptive quarantine area in the emergency department (ED) during a regional coronavirus disease 2019 (COVID-19) outbreak. Methods: A descriptive cross-sectional, retrospective study conducted in a single institution. General patient demographic data, initial vital sign, symptoms, and patient outcome was collected from January to March of 2020. Data were compared according to the implementation of a new protocol involving pretriage screening and risk stratification. Outcome was also analyzed according to quarantine areas, including conventional, negative pressured, cohort, or preemptive quarantine area. Results: The pretriage clinic lowered the volume of low severity patients entering emergency department. Preemptive and cohort quarantine area provided more care to febrile patients compared with conventional quarantine area with longer length of hospital stay and lower mortality. After implementing the new protocol, emergency department in the study hospital was not closed again. Conclusions: In a regional outbreak of an epidemic, pretriage clinic safely screened infectious patients from entering ED. Expanded preemptive quarantine area increased surge capacity on quarantine area. An infectious disease protocol implementing 2 treatment areas may contribute to preserve and maintain ED function. Moon, Sungbae; Ryoo, Hyun Wook; Cho, Jae Wan; Jung, Haewon Kyungpook Natl Univ, Sch Med, Dept Emergency Med, Daegu, South Korea Moon, Sungbae/F-4010-2015 ryoo@knu.ac.kr; DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS DISASTER MED PUBLIC 1935-7893 1938-744X 17 SCIE;SSCI PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 2021 5.556 15.1 0 triage; COVID-19; disaster; emergency department; epidemic preparedness English 2021 2021-08-31 10.1017/dmp.2021.278 바로가기 바로가기 바로가기
Article In Vitro Prebiotic and Anti-Colon Cancer Activities of Agar-Derived Sugars from Red Seaweeds Numerous health benefits of diets containing red seaweeds or agar-derived sugar mixtures produced by enzymatic or acid hydrolysis of agar have been reported. However, among various agar-derived sugars, the key components that confer health-beneficial effects, such as prebiotic and anti-colon cancer activities, remain unclear. Here, we prepared various agar-derived sugars by multiple enzymatic reactions using an endo-type and an exo-type of beta-agarase and a neoagarobiose hydrolase and tested their in vitro prebiotic and anti-colon cancer activities. Among various agar-derived sugars, agarotriose exhibited prebiotic activity that was verified based on the fermentability of agarotriose by probiotic bifidobacteria. Furthermore, we demonstrated the anti-colon cancer activity of 3,6-anhydro-l-galactose, which significantly inhibited the proliferation of human colon cancer cells and induced their apoptosis. Our results provide crucial information regarding the key compounds derived from red seaweeds that confer beneficial health effects, including prebiotic and anti-colon cancer activities, to the host. Yun, Eun Ju; Yu, Sora; Kim, Young-Ah; Liu, Jing-Jing; Kang, Nam; Jin, Yong-Su; Kim, Kyoung Korea Univ, Grad Sch, Dept Biotechnol, Seoul 02841, South Korea; Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA Kim, Kyoung/F-1059-2013; Jin, Yong-Su/L-4530-2013; Kim, Kyoung Heon/F-1059-2013 57908444000; 56784670100; 57207444387; 56447155800; 8315288500; 57204009076; 34770896300 jdjddcld@korea.ac.kr;sora90715@korea.ac.kr;yakim@o.cnu.ac.kr;jingjing@sugarlogix.com;njkang@knu.ac.kr;ysjin@illinois.edu;khekim@korea.ac.kr; MARINE DRUGS MAR DRUGS 1660-3397 19 4 SCIE CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY 2021 6.085 15.1 2.18 2025-07-30 28 29 red seaweeds; agarose; agarotriose; 3; 6-anhydro-l-galactose; prebiotics; anti-colon cancer activity 3,6-anhydro-L-galactose; Agarose; Agarotriose; Anti-colon cancer activity; Prebiotics; Red seaweeds Agar; Antineoplastic Agents; Apoptosis; Bifidobacterium; Cell Proliferation; Colonic Neoplasms; Fermentation; Galactose; HCT116 Cells; Humans; Hydrolysis; Prebiotics; Rhodophyta; Seaweed; 3,6 anhydro l galactose; agar; beta agarase; neoagarobiose hydrolase; unclassified drug; 3,6-anhydrogalactose; agar; antineoplastic agent; galactose; prebiotic agent; antineoplastic activity; apoptosis; Article; Bifidobacterium; cancer cell; cell proliferation; colon cancer; controlled study; enzyme mechanism; human; human cell; in vitro study; nonhuman; seaweed; colon tumor; comparative study; drug effect; fermentation; HCT 116 cell line; hydrolysis; isolation and purification; metabolism; pathology; red alga English 2021 2021-04 10.3390/md19040213 바로가기 바로가기 바로가기 바로가기
Article Mitogen-activated protein kinase 6 negatively regulates secondary wall biosynthesis by modulating MYB46 protein stability in Arabidopsis thaliana The R2R3-MYB transcription factor MYB46 functions as a master switch for secondary cell wall biosynthesis, ensuring the exquisite expression of the secondary wall biosynthetic genes in the tissues where secondary walls are critical for growth and development. At the same time, suppression of its function is needed when/where formation of secondary walls is not desirable. Little is known about how this opposing control of secondary cell wall formation is achieved. We used both transient and transgenic expression of MYB46 and mitogen-activated protein kinase 6 (MPK6) to investigate the molecular mechanism of the post-translational regulation of MYB46. We show that MYB46 is phosphorylated by MPK6, leading to site specific phosphorylation-dependent degradation of MYB46 by the ubiquitin-mediated proteasome pathway. In addition, the MPK6-mediated MYB46 phosphorylation was found to regulate in planta secondary wall forming function of MYB46. Furthermore, we provide experimental evidences that MYB83, a paralog of MYB46, is not regulated by MPK6. The coupling of MPK signaling to MYB46 function provides insights into the tissue- and/or condition-specific activity of MYB46 for secondary wall biosynthesis. Author summary Secondary cell walls are critical for plant growth and of economic importance to humans as fiber, pulp for paper, and as a renewable source of energy. A master switch for secondary wall biosynthesis, MYB46, ensures the exquisite expression of the biosynthetic genes in the tissues where secondary walls are critical. However, suppression of secondary wall formation is needed during impermanent cessation of vegetative growth triggered by environmental stresses. Although the expression of MYB46 is upregulated by abiotic stresses, secondary wall formation may not occur. How is this opposing control achieved? The mitogen-activated protein kinase (MPK) cascade is among the most conserved signal transduction systems in eukaryotes and plays a crucial role in the regulation of biochemical and physiological changes associated with environmental stimuli and phytohormones. In this report, we show that MYB46 is negatively regulated by MPK6 during salt stress, providing a novel insight into a mechanism by which plants incorporate environmental signals into differential regulation of secondary wall biosynthesis. Im, Jong Hee; Ko, Jae-Heung; Kim, Won-Chan; Crain, Brent; Keathley, Daniel; Han, Kyung-Hwan Michigan State Univ, Dept Hort, E Lansing, MI 48824 USA; Natl Acad Agr Sci, Rural Dev Adm, Jeonju, South Korea; Kyung Hee Univ, Coll Life Sci, Dept Plant & Environm New Resources, Yongin, Gyeonggi Do, South Korea; Kyung Hee Univ, Grad Sch Biotechnol, Yongin, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea; Michigan State Univ, Dept Forestry, E Lansing, MI 48824 USA ; Han, Kyung-Hwan/G-6141-2012; Crain, Brent/AAG-2490-2021; KIM, WON/AAJ-4506-2020; Ko, Jae-Heung/A-3370-2013 57210800548; 7402678816; 55492085000; 57191541259; 6506028211; 7402963224 jhko@khu.ac.kr;hanky@msu.edu; PLOS GENETICS PLOS GENET 1553-7404 17 4 SCIE GENETICS & HEREDITY 2021 6.02 15.1 1.05 2025-07-30 18 18 Arabidopsis; Arabidopsis Proteins; Cell Wall; Gene Expression Regulation, Plant; Mitogen-Activated Protein Kinases; Organ Specificity; Plants, Genetically Modified; Promoter Regions, Genetic; Protein Stability; Transcription Factors; Transcriptional Activation; Arabidopsis protein; mitogen activated protein kinase 6; MYB46 protein; MYB83 protein; proteasome; transcription factor; ubiquitin; unclassified drug; Arabidopsis protein; BOTRYTIS SUSCEPTIBLE1 protein, Arabidopsis; mitogen activated protein kinase; MPK6 protein, Arabidopsis; Myb46 protein, Arabidopsis; MYB83 protein, Arabidopsis; transcription factor; Arabidopsis thaliana; Article; biosynthesis; cell wall; controlled study; MAPK signaling; nonhuman; physiological stress; plant cell; plant growth; plant structures; protein degradation; protein expression; protein function; protein phosphorylation; protein stability; salt stress; secondary cell wall; translation regulation; antibody specificity; Arabidopsis; gene expression regulation; genetics; growth, development and aging; promoter region; protein stability; transcription initiation; transgenic plant English 2021 2021-04 10.1371/journal.pgen.1009510 바로가기 바로가기 바로가기 바로가기
Article The Marine-Derived Natural Product Epiloliolide Isolated from Sargassum horneri Regulates NLRP3 via PKA/CREB, Promoting Proliferation and Anti-Inflammatory Effects of Human Periodontal Ligament Cells Currently, periodontitis treatment relies on surgical operations, anti-inflammatory agents, or antibiotics. However, these treatments cause pain and side effects, resulting in a poor prognosis. Therefore, in this study, we evaluated the impact of the compound epiloliolide isolated from Sargassum horneri on the recovery of inflammatory inhibitors and loss of periodontal ligaments, which are essential treatment strategies for periodontitis. Here, human periodontal ligament cells stimulated with PG-LPS were treated with the compound epiloliolide, isolated from S. horneri. In the results of this study, epiloliolide proved the anti-inflammatory effect, cell proliferation capacity, and differentiation potential of periodontal ligament cells into osteoblasts, through the regulation of the PKA/CREB signaling pathway. Epiloliolide effectively increased the proliferation and migration of human periodontal ligament cells without cytotoxicity and suppressed the protein expression of proinflammatory mediators and cytokines, such as iNOS, COX-2, TNF-alpha, IL-6, and IL-1 beta, by downregulating NLRP3 activated by PG-LPS. Epiloliolide also upregulated the phosphorylation of PKA/CREB proteins, which play an important role in cell growth and proliferation. It was confirmed that the anti-inflammatory effect in PG-LPS-stimulated large cells was due to the regulation of PKA/CREB signaling. We suggest that epiloliolide could serve as a potential novel therapeutic agent for periodontitis by inhibiting inflammation and restoring the loss of periodontal tissue. Kim, Eun-Nam; Nabende, Woguti Yvonne; Jeong, Hyeyoon; Hahn, Dongyup; Jeong, Gil-Saeng Keimyung Univ, Coll Pharm, 1095 Dalgubeol Daero, Daegu 42601, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea YVONNE NABENDE, WOGUTI/JPX-0211-2023 57201655294; 57226391868; 57219165769; 36554163400; 57204396456 enkimpharm@gmail.com;yvonwoguti@gmail.com;ddi02084@naver.com;dohahn@knu.ac.kr;gsjeong@kmu.ac.kr; MARINE DRUGS MAR DRUGS 1660-3397 19 7 SCIE CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY 2021 6.085 15.1 1.45 2025-07-30 14 16 Sargassum horneri; periodontitis; protein kinase A (PKA); cAMP-responsive element-binding protein (CREB); epiloliolide TUMOR-NECROSIS-FACTOR; PORPHYROMONAS-GINGIVALIS; SULFATED POLYSACCHARIDE; STEM-CELLS; PATHWAY; LOLIOLIDE; CAROTENOIDS; ACTIVATION; EXPRESSION; APOPTOSIS CAMP-responsive elementbinding protein (CREB); Epiloliolide; Periodontitis; Protein kinase A (PKA); Sargassum horneri Animals; Anti-Inflammatory Agents; Aquatic Organisms; Benzofurans; Biological Products; Cell Line; Cell Proliferation; Humans; NLR Family, Pyrin Domain-Containing 3 Protein; Periodontal Ligament; Sargassum; Signal Transduction; antiinflammatory agent; benzofuran derivative; biological product; cryopyrin; loliolide; animal; aquatic species; cell line; cell proliferation; cytology; drug effect; human; metabolism; periodontal ligament; Sargassum; signal transduction English 2021 2021-07 10.3390/md19070388 바로가기 바로가기 바로가기 바로가기
Article A Tb-based-metal-organic framework prepared under ultrasound for detection of organic amines in aqueous solution through fluorescence quenching A luminescent Tb-benzenetricarboxylate (BTC) metal-organic framework (MOF) was synthesized, ultrasonically, and used (without any functionalization) for selective detection of organic amines through fluorescence quenching of the Tb-metal. Several amines, with various basicity, such as ethylenediamine (ED), diethanolamine (DOA), diethylamine (DEA), triethylamine, pyridine, aniline, and pyrrole were chosen as representative analytes. The quenching efficiency of the amine solutions relied on the basicity of the analytes and steric hindrance between the analytes and MOF. A Tb-BTC MOF, synthesized using ultrasound irradiation, shows better results than MOF synthesized using conventional electrical or microwave heating, which might be the effect of a better dispersion of the MOF due to smaller particle size, higher analyte diffusivity, and higher defect-site contents. The change in the luminescence of the Tb-MOF was attributed to the interaction of amines with the Tb-metal ions of the MOF through coordination/complexation. By applying the luminescent Tb-MOF (prepared with ultrasound), aliphatic organic amines like ED, DOA, and DEA could be detected up to 100 mu M and 2 mu M, with naked eyes and fluorescence spectrophotometry, respectively. However, other chemicals, such as alcohol, ketone, hydrocarbon, and hydrogen peroxide did not quench appreciably the fluorescence of Tb-MOF, suggesting the possible selective detection of amines. (C) 2021 Elsevier B.V. All rights reserved. Ahmed, Imteaz; Lee, Hye Jin; Jhung, Sung Hwa Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea Jhung, Sung/AAO-6683-2021 55377179600; 56569175200; 6701659467 sung@knu.ac.kr; JOURNAL OF MOLECULAR LIQUIDS J MOL LIQ 0167-7322 1873-3166 344 SCIE CHEMISTRY, PHYSICAL;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL 2021 6.633 15.3 1.15 2025-07-30 21 21 Fluorescence sensing in liquids; Metal-organic frameworks; Tb-MOF; Ultrasound-aided synthesis BORONIC ACID-DERIVATIVES; SELECTIVE DETECTION; COORDINATION POLYMER; PROBES; MOF; FABRICATION; MECHANISMS; EMISSION; FACILE Amine detection; Fluorescence sensing in liquids; Metal–organic frameworks; Tb–MOF; Ultrasound-aided synthesis Aniline; Chemical detection; Fluorescence quenching; Ketones; Metals; Microwave heating; Microwave irradiation; Particle size; Ultrasonic applications; Amine detection; Analytes; Fluorescence sensing; Fluorescence sensing in liquid; Metalorganic frameworks (MOFs); Organic amine; Synthesised; Tb–metal–organic framework; Ultrasound-aided synthesis; Metal ions English 2021 2021-12-15 10.1016/j.molliq.2021.117765 바로가기 바로가기 바로가기 바로가기
Meeting Abstract Comparison of quality characteristics, palatability, and serum biochemical parameters between normal and PSE-like condition chickens Lee, Boin; Kim, Jae Yeong; Choi, Young Min Kyungpook Natl Univ, Daegu, South Korea JOURNAL OF ANIMAL SCIENCE J ANIM SCI 0021-8812 1525-3163 99 SCIE AGRICULTURE, DAIRY & ANIMAL SCIENCE 2021 3.338 15.3 1 PSE-like chicken; meat quality; serum biochemical parameters English 2021 2021-11 바로가기 바로가기
Meeting Abstract Customized Color Settings of Digitally Assisted Vitreoretinal Surgery Enable a 3-Fold Decrease of Indocyanine Green Stain Concentration Park, Dong Ho; Park, Su Jin; Do, Jae Rock Kyungpook Natl Univ, Dept Ophthalmol, Daegu, South Korea INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE INVEST OPHTH VIS SCI 0146-0404 1552-5783 62 8 SCIE OPHTHALMOLOGY 2021 4.925 15.3 0 English 2021 2021-06 바로가기 바로가기
Article Deep eutectic solvent mediated nanostructured copper oxide as a positive electrode material for hybrid supercapacitor device Metal oxides have received significant attention for various applications over the last few decades due to their better structural, morphological, and electrochemical properties. Herein, a green approach is introduced for the synthesis of nanostructured CuO using a choline chloride urea (CCU)-based deep eutectic solvent (DES) method. The effects of varying reaction times upon the surface morphological and electrochemical properties of the CuO are examined. In particular, the CuO sample obtained at 12 h of reaction time is shown to exhibit a porous nanograin-like surface morphology with a grain size of less than 20 nm and an excellent specific capacity (Cs) of 176 mAh g(-1) at a scan rate of 5 mV s(-1). Further, the practicability of the CuO-based electrode is demonstrated by the fabrication of a CuO//activated carbon (AC) hybrid supercapacitor device. The CuO//AC shows a noteworthy electrochemical performance, with a Cs of 82 mAh g(-1), specific energy of 35.86 Wh kg(-1), a specific power of 2017 W kg(-1), and a long-term stability of 98% after 2000 cycles. (C) 2021 Published by Elsevier B.V. Shinde, Surendra K.; Karade, Swapnil S.; Yadav, Hemraj M.; Maile, Nagesh C.; Ghodake, Gajanan S.; Jagadale, Ajay D.; Jalak, Monali B.; Velhal, Ninad; Kumar, Raman; Lee, Dae Sung; Kim, Dae-Young Dongguk Univ, Coll Life Sci & Biotechnol, Dept Biol & Environm Sci, 32 Dongguk Ro,Biomed Campus, Goyang Si 10326, Gyeonggi Do, South Korea; Yonsei Univ, Dept Chem & Bimol Engn, Electrochem Energy Lab, Seoul, South Korea; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; SASTRA Deemed Univ, Ctr Energy Storage & Convers, Sch Elect & Elect Engn, Thanjavur 613401, Tamil Nadu, India; Shivaji Univ, Dept Phys, Kolhapur, Maharashtra, India; Kyungpook Natl Univ, Dept Polymer Sci, Polymer Thin Film Mat Lab, 80 Daehak Ro, Daegu, South Korea Velhal, Ninad/O-2578-2014; Maile, Nagesh/AFD-8838-2022; Karade, Swapnil/AAA-8285-2020; Kumar, Raman/S-2880-2016; Shinde, Santaji/LFT-9528-2024; Jagadale, Ajay/O-5253-2014 55776351000; 56674484600; 55389590800; 57193804539; 22979024500; 44161199800; 57203877390; 56116686900; 57192371095; 55568524907; 55742887400 sbpkim@dongguk.edu; JOURNAL OF MOLECULAR LIQUIDS J MOL LIQ 0167-7322 1873-3166 341 SCIE CHEMISTRY, PHYSICAL;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL 2021 6.633 15.3 1.23 2025-07-30 15 16 Deep eutectic solvent; Nanostructure; Copper Oxide; Nanograin; Hybrid supercapacitor device THIN-FILMS; ELECTROCHEMICAL PERFORMANCE; CHEMICAL-SYNTHESIS; CUO ELECTRODES; CARBON; NANOSHEETS; NANOPARTICLES; FABRICATION; COMPOSITES; ADSORPTION Copper Oxide; Deep eutectic solvent; Hybrid supercapacitor device; Nanograin; Nanostructure Chlorine compounds; Copper oxides; Electrochemical electrodes; Electrochemical properties; Eutectics; Morphology; Nanostructures; Solvents; Surface morphology; Surface reactions; Urea; Cs$++$; Deep eutectic solvents; Electrochemicals; Hybrid supercapacitor device; Hybrid supercapacitors; Metal-oxide; Nano grains; Nanostructured copper; Positive-electrode materials; Property; Supercapacitor English 2021 2021-11-01 10.1016/j.molliq.2021.117319 바로가기 바로가기 바로가기 바로가기
Article Effective and selective removal of organic pollutants from aqueous solutions using 1D hydroxyapatite-decorated 2D reduced graphene oxide nanocomposite The efficient and selective removal of toxic dye molecules from water/surface water remains a problematic task, owing to their high water solubility and low biodegradability. We fabricated the hydroxyapatite-decorated reduced graphene oxide (HA@rGO) nanocomposites via a simple hydrothermal process and used them as efficient adsorbents for the diazo dyes removal. In the batch experiments, the resultant HA@rGO nanocomposites exhibited fast and excellent removal performance for Trypan blue and Congo red dye molecules in a wide pH range and the maximum adsorption efficiencies of 146.51 and 150.09 mg/g, respectively. Several characterization analysis results demonstrated that the removal performance of the HA@rGO nanocomposites for the toxic dyes was mainly driven by electrostatic, hydrophobic, pi-pi interactions, and H-bonding between the adsorbents and dye molecules in the aqueous solution. Ubiquitous co-anions have significant influence on the dye removal performance of the HA@rGO nanocomposites because of the higher ionic radius and electronegativity. After adsorption, the exhausted HA@rGO nanocomposites could be regenerated in alkaline solution and reused throughout five successive adsorption-desorption cycles. We believe that the adsorbent fabricated in this work can be effectively used to remove toxic diazo dye molecules from aqueous media. (C) 2021 Elsevier B.V. All rights reserved. Karthikeyan, Perumal; Nikitha, Manuvelraja; Pandi, Kalimuthu; Meenakshi, Sankaran; Park, Chang Min Deemed Univ, Gandhigram Rural Inst, Dept Chem, Dindigul 624302, Tamil Nadu, India; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Korea Univ, Div Environm Sci & Ecol Engn, Anam Ro, Seoul 02841, South Korea Meenakshi, Sankaran/AAF-5748-2020; Karthikeyan, Perumal/T-6719-2019; Park, Chang Min/CAA-8506-2022; Kalimuthu, Pandi/AAV-6987-2021 57207499412; 57219268697; 56273058900; 58099005900; 57209588953 drkpandi@korea.ac.kr;sankaranmeenakshi2014@gmail.com;cmpark@knu.ac.kr; JOURNAL OF MOLECULAR LIQUIDS J MOL LIQ 0167-7322 1873-3166 331 SCIE CHEMISTRY, PHYSICAL;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL 2021 6.633 15.3 0.98 2025-07-30 7 13 Hydroxyapatite; rGO; HA@rGO; Adsorption; Diazo dye MALACHITE GREEN-DYE; CONGO-RED; ADSORPTION; THERMODYNAMICS; PERFORMANCE; KINETICS; SORPTION; MODEL; WATER; BLUE Adsorption; Diazo dye; HA@rGO; Hydroxyapatite; rGO Alkalinity; Azo dyes; Biodegradability; Chemical bonds; Electronegativity; Graphene; Hydroxyapatite; Molecules; Nanocomposites; Organic pollutants; Stripping (dyes); Diazo dyes; Dye molecule; Dye removal; Effective removals; Graphene oxide nanocomposites; Hydroxyapatite-decorated reduced graphene oxide; Reduced graphene oxides; Removal performance; Selective removal; Toxic dyes; Adsorption English 2021 2021-06-01 10.1016/j.molliq.2021.115795 바로가기 바로가기 바로가기 바로가기
Article Efficient and selective sequestration of perfluorinated compounds and hexavalent chromium ions using a multifunctional spinel matrix decorated carbon backbone N-rich polymer and their mechanistic investigations The removal of emerging contaminants including heavy metals and perfluorinated compounds has been an increasing concern globally due to their harmful effects on human health and other creatures in the environment. Mixtures of perfluorinated chemicals with heavy metals are often found in polluted areas, which is a critical challenge in water remediation. This study proposes a multifunctional magnetic adsorbent, cerium-incorporated ferrite (CMF) decorated polyaniline (PANI) (CMFx%@PANI) hybrid composites by co-precipitation followed by calcination methods. FTIR, VSM, and zeta potential measurements confirmed the successful incorporation of CMF on PANI. The textural properties and surface morphologies of CMFx%@PANI were examined using BET, FE-SEM, HR-TEM, and EDX analysis. The conventional raw forms of CMF nanoparticles and PANI were inadequate for the removal of the mentioned contaminants. However, the synchronous role of PANI with CMF nanoparticles exhibited higher adsorption capacities toward the perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), and hexavalent chromium (Cr(VI)) ions than the individual forms. The sorption kinetics and isotherms indicated that adsorption behaviors of PFOA, PFOS, and Cr(VI) onto CMFx%@PANI followed a pseudo-second-order and Langmuir isotherm model, respectively. The feasible mechanisms of PFOA, PFOS, and Cr(VI) adsorption on CMFx%@PANI were investigated using XPS analysis. (C) 2021 Elsevier B.V. All rights reserved. Elanchezhiyan, S. Sd; Prabhu, Subbaiah Muthu; Karthikeyan, Perumal; Park, Chang Min Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Alagappa Univ, Dept Ind Chem, Karaikkudi 630003, Tamil Nadu, India; Gandhigram Rural Inst Deemed Univ, Dept Chem, Dindigul 624302, Tamil Nadu, India Muthu Prabhu, Subbaiah/AFN-4547-2022; Karthikeyan, Perumal/T-6719-2019; Park, Chang Min/CAA-8506-2022 54894383700; 7101753878; 57207499412; 57209588953 cmpark@knu.ac.kr; JOURNAL OF MOLECULAR LIQUIDS J MOL LIQ 0167-7322 1873-3166 326 SCIE CHEMISTRY, PHYSICAL;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL 2021 6.633 15.3 0.82 2025-07-30 10 12 Magnetic ferrite; PANI; PFOA; PFOS; Hexavalent chromium Hexavalent chromium; Magnetic ferrite; PANI; PFOA; PFOS Adsorption; Carbon; Heavy metals; Isotherms; Metal ions; Nanoparticles; Polyaniline; Adsorption capacities; Hexavalent chromium ions; Langmuir isotherm models; Perfluorinated chemicals; Perfluorinated compounds; Perfluorooctanoic acid; Selective sequestrations; Zeta potential measurements; Chromium compounds English 2021 2021-03-15 10.1016/j.molliq.2021.115336 바로가기 바로가기 바로가기 바로가기
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Language 논문이 작성된 언어입니다. 대부분 English이며, 그 외 다양한 언어로 작성된 논문이 포함될 수 있습니다.
Publication Year 논문이 출판된 연도입니다.
Publication Date 논문의 정확한 출판 날짜입니다 (년-월-일 형식).
DOI Digital Object Identifier. 디지털 객체 식별자로, 논문을 고유하게 식별하는 영구적인 식별번호입니다. 이를 통해 논문의 온라인 위치를 찾을 수 있습니다.