연구성과로 돌아가기
2024 연구성과 (58 / 286)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Real-time in vivo monitoring of intraocular pressure distribution in the anterior chamber and vitreous chamber for diagnosis of glaucoma | Glaucoma causes irreversible vision loss due to optic nerve damage and retinal cell degeneration. Since high intraocular pressure (IOP) is a major risk factor for glaucoma development, accurate IOP measurement is crucial, especially intravitreal IOP affecting the optical nerve and cells. However, conventional methods have limits in selectively and directly detecting local retina pressure. Here, we present continuous measurements of local IOP values in the anterior chamber and vitreous chamber of living animals using minimally invasive probes with pressure-sensitive transistors. After inducing glaucoma in animal models, we compared the local IOP distribution between normal and glaucomatous eyes. We also compared IOP values detected in the cornea using tonometry measurements. Our findings revealed that glaucoma induced higher IOP in the vitreous chamber than in the anterior chamber, indicating that measuring IOP in the vitreous chamber is key to the glaucoma model. This progress offers future directions for diagnosis and treatment of glaucoma. | Seo, Hunkyu; Hong, Yeon-Mi; Chung, Won Gi; Park, Wonjung; Lee, Jakyoung; Kim, Hong Kyun; Byeon, Suk Ho; Kim, Dai Woo; Park, Jang-Ung | Yonsei Univ, Dept Mat Sci & Engn, Coll Engn, Seoul 03722, South Korea; Yonsei Univ, Inst Basic Sci IBS, Ctr Nanomed, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu 41944, South Korea; Yonsei Univ, Coll Med, Dept Ophthalmol, Seoul 03722, South Korea; Yonsei Univ, Coll Med, Dept Neurosurg, Seoul 03722, South Korea; Yonsei Univ, Adv Sci Inst, Grad Program Nano Biomed Engn NanoBME, Seoul 03722, South Korea | Park, Jang-Ung/E-9224-2010; Kim, Hong Kyun/ITT-7758-2023 | 57217280976; 58663176500; 57222722406; 57410336100; 57196140253; 57218260940; 58027755600; 57095192800; 11739935500 | jang-ung@yonsei.ac.kr;proector97@gmail.com; | SCIENCE ADVANCES | SCI ADV | 2375-2548 | 10 | 6 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 12.5 | 8.5 | 3.27 | 2025-05-07 | 12 | 11 | OPEN-ANGLE GLAUCOMA; INTRACRANIAL-PRESSURE; PATHOPHYSIOLOGY; APPLANATION; TONOMETRY | Animals; Anterior Chamber; Glaucoma; Intraocular Pressure; Retina; Tonometry, Ocular; Cell death; Eye protection; Ophthalmology; Risk assessment; Anterior chamber; In-vivo; Intraocular pressure; Nerve damage; Optic nerve; Pressure values; Real- time; Retinal cells; Vision loss; Vivo monitoring; animal; anterior eye chamber; glaucoma; intraocular pressure; oculoplethysmography; retina; Animals | English | 2024 | 2024-02-07 | 10.1126/sciadv.adk7805 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Reconceptualized Family Resemblance Approach to the Nature of Science in Middle-School Science Textbooks from Brazil and South Korea Regarding Environmental Issues | This study analyzes the elements of the nature of science (NOS) with respect to environmental issues in middle-school science textbooks, covering three collections (nine and 12 books) from South Korea and Brazil, respectively. Content analysis was used to categorize the elements of the NOS using the reconceptualized family resemblance approach to the NOS (RFN) framework. The results showed that middle-school science textbooks mentioned the NOS when discussing environmental issues. The Brazilian textbooks mentioned RFN categories more often than the South Korean textbooks (103 vs. 24). Specifically, professional activities were the most mentioned RFN category in the Brazilian textbooks (32, 31.1%), while social values (6, 25%) were most mentioned in the South Korean textbooks. Additionally, the categories of aims and values (2, 1.9%), scientific ethos (1, 1.0%), and political power structures (4, 3.9%) were present in the textbooks from Brazil but not in those from South Korea. The financial system category was not identified in the textbooks of either country. Notably, most mentions of RFN categories in the textbooks were implicit in nature and did not have in-depth descriptions. Based on these results, this study discusses how exploring the general principles of the NOS and its specific applications in environmental issues can promote the role of science textbooks in environmental education. Further, the study findings contribute to clarifying the differences between South Korea and Brazil regarding environmental issues associated with the NOS, indicating that both countries can learn from each other’s perspectives on environmental education and the NOS. © The Author(s), under exclusive licence to Springer Nature B.V. 2024. | Pereira, Brenda Braga; Ha, Sangwoo | Department of Physics Education, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, South Korea; Department of Physics Education, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, South Korea, Science Education Research Institute, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, South Korea | 57428497100; 55215468100 | hswgcb@knu.ac.kr; | Science and Education | SCI EDUC-NETHERLANDS | 0926-7220 | 1573-1901 | SSCI;AHCI;SCIE | EDUCATION & EDUCATIONAL RESEARCH;HISTORY & PHILOSOPHY OF SCIENCE | 2024 | 2.5 | 8.5 | 0.7 | 2025-04-16 | 1 | English | Article in press | 2024 | 10.1007/s11191-024-00514-2 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Retention-aware zero-shifting technique for Tiki-Taka algorithm-based analog deep learning accelerator | We present the fabrication of 4 K-scale electrochemical random-access memory (ECRAM) cross-point arrays for analog neural network training accelerator and an electrical characteristic of an 8 x 8 ECRAM array with a 100% yield, showing excellent switching characteristics, low cycle-to-cycle, and device-to-device variations. Leveraging the advances of the ECRAM array, we showcase its efficacy in neural network training using the Tiki-Taka version 2 algorithm (TTv2) tailored for non-ideal analog memory devices. Through an experimental study using ECRAM devices, we investigate the influence of retention characteristics on the training performance of TTv2, revealing that the relative location of the retention convergence point critically determines the available weight range and, consequently, affects the training accuracy. We propose a retention-aware zero-shifting technique designed to optimize neural network training performance, particularly in scenarios involving cross-point devices with limited retention times. This technique ensures robust and efficient analog neural network training despite the practical constraints posed by analog cross-point devices. | Noh, Kyungmi; Kwak, Hyunjeong; Son, Jeonghoon; Kim, Seungkun; Um, Minseong; Kang, Minil; Kim, Doyoon; Ji, Wonjae; Lee, Junyong; Jo, Hwijeong; Woo, Jiyong; Lee, Hyung-Min; Kim, Seyoung | Pohang Univ Sci & Technol, Dept Mat Sci & Engn, Pohang 37673, South Korea; Korea Univ, Sch Elect Engn, Seoul, 02841, South Korea; Korea Univ, Dept Semicond Syst Engn, Seoul 02841, South Korea; Kyungpook Natl Univ, Dept Elect Engn, Daegu 41566, South Korea | 57326724000; 57203745904; 58634750400; 58634750300; 57221335302; 57825713100; 59176888900; 57419287700; 59176814500; 59164639900; 53985749100; 7501483334; 57211871375 | kimseyoung@postech.ac.kr;hyungmin@korea.ac.kr; | SCIENCE ADVANCES | SCI ADV | 2375-2548 | 10 | 24 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 12.5 | 8.5 | 1.23 | 2025-05-07 | 6 | 6 | CROSSBAR ARRAY; MEMORY; HARDWARE; NETWORK; RRAM | Neural networks; Random access storage; Analog neural network; Cross point; Cross-point array; Electrical characteristic; Electrochemicals; Memory array; Neural networks trainings; Performance; Random access memory; Switching characteristics; adult; algorithm; article; controlled study; deep learning; drug therapy; experimental study; male; nerve cell network; retention time; Deep learning | English | 2024 | 2024-06-14 | 10.1126/sciadv.adl3350 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Sampled-data based asynchronous control for persistent dwell-time switched systems: A delay-dependent Lyapunov functional approach | This paper mainly investigates the sampled -data control issue for switched systems with persistent dwell -time under input time delay. Unlike the common controller design, the existence of the delay makes it possible for the subsystem switching to occur during the sampling intervals, which leads to asynchronous problem. By means of the novel functional consisting of piecewisecontinuous delay -dependent Lyapunov functional and looped-functionals, some solvability criteria are given under sufficient consideration of the switching frequency. Furthermore, the stability criterion is formulated by the sum of squares program and the global optimal solution is further provided, which exponentially stabilizes the system. Finally, a numerical example as well as an application design of the tunnel diode circuit are studied, both of which demonstrate the proposed method's validity and feasibility. | Zhang, Pengcheng; Wang, Jianyu; Lee, Sangmoon; Liu, Yajuan | Nanjing Univ Sci & Technol, Sch Automat, Nanjing 210094, Peoples R China; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; North China Elect Power Univ, Sch Control & Comp Engn, Beijing 102206, Peoples R China | zhang, pengcheng/B-2618-2008; Yajuan, Liu/JZD-8537-2024; 王, 剑宇/IQS-3673-2023; Lee, Sangmoon/C-4502-2018 | 58043447700; 57211089817; 59510733500; 55255775300 | moony@knu.ac.kr; | JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS | J FRANKLIN I | 0016-0032 | 1879-2693 | 361 | 7 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;ENGINEERING, MULTIDISCIPLINARY;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS | 2024 | 4.2 | 8.5 | 0.82 | 2025-05-07 | 3 | 3 | Switched systems; Persistent dwell-time switching; Sampled-data control; Sum of squares; Lyapunov functional | LINEAR-SYSTEMS; STABILITY; STABILIZATION; DESIGN | Lyapunov functional; Persistent dwell-time switching; Sampled-data control; Sum of squares; Switched systems | Controllers; Delay control systems; Lyapunov functions; Numerical methods; Sampled data control systems; Asynchronous control; Delay dependent; Dwell time; Dwell-time switching; Lyapunov functionals; Persistent dwell-time switching; Sampled data; Sampled-data control; Sums of squares; Switched system; Stability criteria | English | 2024 | 2024-05 | 10.1016/j.jfranklin.2024.106789 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Stabilization with unknown-input estimation for time-delayed systems using functional-observer-based feedback control design | This paper focuses on the stabilization and unknown -input estimation (UIE) problem of continuous -time delayed systems by virtue of functional -observer (FO) -based feedback controller. It allows us to estimate the unknown external variable that degrades the system performance with respect to the partially known input of the system. In particular, the unknown inputs are considered in system dynamics's state as well as in output, which makes the addressed problem to be more applicable. In addition to that, the aim is then to design minimal order functional observer. Notably, the FO -based feedback control law is introduced for the first time and it is used to ensure the asymptotic stabilization with UIE of the proposed system. Whilst, the design and analysis of UIE and FO is based on Lyapunov stability theory and applying the inequality analysis technique, the sufficient stability conditions are established in the forms of matrix inequality. Eventually, the numerical examples with simulation results are provided to validate the practicability and efficacy of the developed control strategy. | Harshavarthini, S.; Gomathi, D.; Lee, S. M. | VIT Univ, Div Math, Sch Adv Sci, Chennai 600127, India; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | Shanmugam, Harshavarthini/AAK-3178-2021; Lee, Sangmoon/C-4502-2018 | 57204646660; 59771327400; 59510733500 | moony@knu.ac.kr; | JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS | J FRANKLIN I | 0016-0032 | 1879-2693 | 361 | 8 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;ENGINEERING, MULTIDISCIPLINARY;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS | 2024 | 4.2 | 8.5 | 0 | 2025-05-07 | 0 | 0 | Functional observer; Unknown-input observer; Continuous-time delayed systems; Lyapunov stability theory | DESCRIPTOR SYSTEMS; STOCHASTIC-SYSTEMS | Continuous-time delayed systems; Functional observer; Lyapunov stability theory; Unknown-input observer | Continuous time systems; Control theory; Feedback control; Time delay; Continous time; Continuous-time delayed system; Control design; Estimation problem; Functional observer; Lyapunov's stability theories; Observer-based feedback control; Time-delayed systems; Unknown input observer; Unknown-input estimations; Stabilization | English | 2024 | 2024-05 | 10.1016/j.jfranklin.2024.106794 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Biological Age Estimation Based On Multi-domain Biomarkers In Older Adults | Kim, Miji; Kim, Suhyeon; Jung, Heeeun; Shin, Hyung Eun; Won, Chang Won | Kyung Hee Univ, Seoul, South Korea; Kyungpook Natl Univ, Daegu, South Korea; Emory Univ, Emory Musculoskeletal Inst, Atlanta, GA USA | mijiak@khu.ac.kr; | MEDICINE & SCIENCE IN SPORTS & EXERCISE | MED SCI SPORT EXER | 0195-9131 | 1530-0315 | 56 | 10 | SCIE | SPORT SCIENCES | 2024 | 3.9 | 8.6 | 0 | English | 2024 | 2024-10 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | Cardioprotective Effect of SGLT2 Inhibitor in Diabetic Kidney Transplant Recipients: A Multicenter Propensity Score Matched Study | Introduction: Kidney transplantation (KT) improves the cardiovascular outcomes of patients with end- stage kidney disease. However, cardiovascular disease remains the leading cause of premature death and graft loss in KT recipients (KTRs) with diabetes. We evaluated the cardioprotective effects of sodium- glucose cotransporter 2 inhibitors (SGLT2i) in KTRs with diabetes. Methods: A total of 750 KTRs with diabetes were enrolled from 6 tertiary hospitals. Among them, 129 patients (17.2%) were prescribed SGLT2i. The primary outcome was the incidence of major adverse cardiovascular events (MACE), which comprised myocardial infarction (MI), death from cardiovascular causes, hospitalization for heart failure, and stroke. Multivariable Cox regression analysis and propensity score matching were used to investigate the effect of SGLT2i on clinical outcomes. Results: In the matched cohort, MACE occurred in 5 patients (3.9%) in the SGLT2i group and 15 patients (11.8%) in the non-SGLT2i group, out of 127 patients in each group over 55.3 months. The incidence of MACE and MI was lower in the SGLT2i group than in the non-SGLT2i group (P P = 0.036 and 0.008, respectively). In multivariate analysis, the SGLT2i group had a lower risk of MACE and MI than the nonSGLT2i group (adjusted hazard ratio [HR], 0.30 and 0.04; 95% confidence interval [CI], 0.10-0.88 and 0.004-0.40; P = 0.028 and 0.006, respectively). There was no difference in the incidence of urinary tract infection (UTI) between the 2 groups. Conclusion: SGLT2i significantly decreased the risk of cardiovascular events in KTRs with diabetes, particularly lowering the incidence of MI and death from cardiovascular causes. SGLT2i can be used to reduce the burden of cardiovascular disease in KTRs with diabetes. | Lim, Jeong-Hoon; Kwon, Soie; Seo, Yu Jin; Kim, Young Hoon; Kwon, Hyunwook; Kim, Yon Su; Lee, Hajeong; Kim, Yong-Lim; Kim, Chan-Duck; Park, Sun-Hee; Hwang, Deokbi; Yun, Woo-Sung; Kim, Hyung-Kee; Huh, Seung; Lee, Jong Soo; Yoo, Kyung Don; Jeong, Jong Cheol; Lee, Jeonghwan; Lee, Jung Pyo; Cho, Jang-Hee | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Asan Med Ctr, Dept Surg, Div Kidney Transplantat, Seoul, South Korea; Univ Ulsan, Coll Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Surg, Daegu, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Internal Med, Ulsan, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul, South Korea | Kim, Hyung-Kee/JBR-8125-2023; Lee, Hyo/G-6299-2019; Cho, Jang-hee/ABD-3534-2020; Yoo, Kyung/AAK-8096-2020; Kim, Young-Hoon/E-5614-2012; Lim, Jeong-Hoon/ABE-6003-2020; Lee, Jeonghwan/C-5214-2011; Park, Sun-Hee/LMN-0033-2024; Kim, Yong-Lim/AGK-3172-2022 | 55360244300; 57206477140; 59167627900; 57281310600; 56306126900; 7410205767; 36554389800; 55633533600; 8558530700; 7501831741; 57194422879; 35070717000; 35169819900; 7101832929; 57201264463; 56603636300; 37761626800; 57203144567; 56028990400; 7403536291 | jh-cho@knu.ac.kr; | KIDNEY INTERNATIONAL REPORTS | KIDNEY INT REP | 2468-0249 | 9 | 8 | SCIE | UROLOGY & NEPHROLOGY | 2024 | 5.7 | 8.6 | 3.43 | 2025-05-07 | 4 | 6 | diabetes mellitus; kidney function; kidney transplantation; major adverse cardiovascular outcome | RENAL-TRANSPLANT; CARDIOVASCULAR-DISEASE; HEART-FAILURE; OUTCOMES; EMPAGLIFLOZIN; MELLITUS | diabetes mellitus; kidney function; kidney transplantation; major adverse cardiovascular outcome; sodium-glucose cotransporter 2 inhibitors | angiotensin 2 receptor antagonist; angiotensin receptor antagonist; cyclosporine; dipeptidyl carboxypeptidase inhibitor; dipeptidyl peptidase IV inhibitor; insulin; metformin; sodium glucose cotransporter 2 inhibitor; sulfonylurea; tacrolimus; adult; Article; cardiovascular mortality; cerebrovascular accident; clinical outcome; cohort analysis; cumulative incidence; diabetes mellitus; disease burden; drug safety; end stage renal disease; female; graft recipient; heart failure; heart infarction; heart protection; hospitalization; human; ketoacidosis; kidney transplantation; major adverse cardiac event; major clinical study; male; middle aged; multicenter study (topic); propensity score; retrospective study; risk reduction; tertiary care center; urinary tract infection | English | 2024 | 2024-08 | 10.1016/j.ekir.2024.05.022 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | COVID-19 induced seizure in a tertiary medical centre in Korea | Jeon, J-Y; Lee, H-W | Kyungpook Natl Univ, Sch Med, Chilgok Hosp, Daegu, South Korea | EPILEPSIA | EPILEPSIA | 0013-9580 | 1528-1167 | 65 | SCIE | CLINICAL NEUROLOGY | 2024 | 6.6 | 8.6 | 0 | English | 2024 | 2024-11 | 바로가기 | 바로가기 | |||||||||||||||||
| ○ | ○ | Article | Determining arsenic stress tolerance genes in rice (Oryza sativa L.) via genomic insights and QTL mapping with double haploid lines | Arsenic, a hazardous heavy metal with potent carcinogenic properties, significantly affects key rice-producing regions worldwide. In this study, we present a quantitative trait locus (QTL) mapping investigation designed to identify candidate genes responsible for conferring tolerance to arsenic toxicity in rice (Oryza sativa L.) during the seedling stage. This study identified 17 QTLs on different chromosomes, including qCHC-1 and qCHC-3 on chromosome 1 and 3 related to chlorophyll content and qRFW-12 on chromosome 12 related to root fresh weight. Gene expression analysis revealed eight candidate genes exhibited significant upregulation in the resistant lines, OsGRL1, OsDjB1, OsZIP2, OsMATE12, OsTRX29, OsMADS33, OsABCG29, and OsENODL24. These genes display sequence alignment and phylogenetic tree similarities with other species and engaging in protein-protein interactions with significant proteins. Advanced gene-editing techniques such as CRISPR-Cas9 to precisely target and modify the candidate genes responsible for arsenic tolerance will be explore. This approach may expedite the development of arsenic-resistant rice cultivars, which are essential for ensuring food security in regions affected by arsenic-contaminated soil and water. | Asif, Saleem; Kim, Nari; Jan, Rahmatullah; Asaf, Sajjad; Farooq, Muhammad; Khan, Waleed; Khan, Zakirullah; Kim, Eun-Gyeong; Jang, Yoon-Hee; Park, Jae Ryoung; Zhao, Dan Dan; Kim, Kyung-Min | Kyungpook Natl Univ, Grad Sch, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa, Oman; Jeonbuk Natl Univ, Coll Agr & Life Sci, Agr Biol, Jeonju, South Korea; Natl Acad Agr Sci, Rural Dev Adm, Natl Agrobiodivers Ctr, Jeonju 54874, South Korea; RDA, Gene Engn Div, Natl Inst Agr Sci, Jeonju 54874, South Korea; Rural Dev Adm, Natl Inst Crop Sci, Crop Breeding Div, Wonju 55365, South Korea; Rural Dev Adm, Natl Inst Crop Sci, Crop Fdn Res Div, Wonju 55365, South Korea | ; Asaf, Sajjad/ABA-3647-2021; Kim, Kyung-Min Kim/C-7007-2014; Jan, Rahmatullah/LFU-1421-2024; ZHAO, DANDAN/HIK-2130-2022 | 57396413700; 57395985700; 57201981969; 56595059900; 57200621537; 59899372800; 57822855200; 58810294300; 57221496070; 57219901992; 57211205505; 57459517300; 34868260300 | kkm@knu.ac.kr; | PLANT PHYSIOLOGY AND BIOCHEMISTRY | PLANT PHYSIOL BIOCH | 0981-9428 | 1873-2690 | 214 | SCIE | PLANT SCIENCES | 2024 | 5.7 | 8.6 | 1.03 | 2025-05-07 | 3 | 3 | Arsenic; DNAJ protein; Metal cation transporter ZIP; MATE12; Quantitative trait locus | METAL TRANSPORTER; ZINC TRANSPORTER; HEAVY-METAL; PHYTOTOXICITY; ACCUMULATION; EXPRESSION; SPECIATION; FAMILY; IDENTIFICATION; MULTIDRUG | Arsenic; DNAJ protein; MATE12; Metal cation transporter ZIP; Quantitative trait locus | Arsenic; Chromosome Mapping; Chromosomes, Plant; Gene Expression Regulation, Plant; Genes, Plant; Haploidy; Oryza; Plant Proteins; Quantitative Trait Loci; Stress, Physiological; arsenic; plant protein; chromosomal mapping; drug effect; gene expression regulation; genetics; haploidy; metabolism; Oryza; physiological stress; plant chromosome; plant gene; quantitative trait locus | English | 2024 | 2024-09 | 10.1016/j.plaphy.2024.108941 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Global Warming-Induced Warmer Surface Water over the East China Sea Can Intensify Typhoons like Hinnamnor | Kim, Yeon-Hee; Lee, Minkyu; Min, Seung-Ki; Park, Doo-Sun R.; Cha, Dong-Hyun; Byun, Young-Hwa; Heo, Junghwa | Pohang Univ Sci & Technol, Div Environm Sci & Engn, Pohang, South Korea; Korea Inst Energy Res, Renewable Energy Big Data Lab, Daejeon, South Korea; Yonsei Univ, Inst Convergence Res & Educ Adv Technol, Incheon, South Korea; Kyungpook Natl Univ, Dept Earth Sci Educ, Daegu, South Korea; Ulsan Natl Inst Sci & Technol, Dept Civil Urban Earth & Environm Engn, Ulsan, South Korea; Korea Meteorol Adm, Natl Inst Meteorol Sci, Climate Change Res Team, Seogwipo, South Korea | Min, Seung-Ki/B-1431-2010; Cha, Dong-Hyun/F-4901-2015; BYUN, Young-Hwa/JCO-1048-2023; Park, Doo-Sun/U-9448-2019; Byun, Young-Hwa/JCO-1048-2023 | 58417260700; 57211620300; 57192273006; 37117659000; 55418553100; 34568038900; 57194433169 | skmin@postech.ac.kr; | BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY | B AM METEOROL SOC | 0003-0007 | 1520-0477 | 105 | 8 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2024 | 5.9 | 8.6 | 0.99 | 2025-05-07 | 1 | 1 | English | 2024 | 2024-08 | 10.1175/bams-d-23-0240.1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Inhibitory Regulation of FOXO1 in PPARδ Expression Drives Mitochondrial Dysfunction and Insulin Resistance | Forkhead box O1 (FOXO1) regulates muscle growth, but the metabolic role of FOXO1 in skeletal muscle and its mechanisms remain unclear. To explore themetabolic role of FOXO1 in skeletal muscle, we generated skeletal muscle-specific Foxo1 inducible knockout (mFOXO1 iKO) mice and fed them a high-fat diet to induce obesity. We measured insulin sensitivity, fatty acid oxidation, mitochondrial function, and exercise capacity in obese mFOXO1 iKO mice and assessed the correlation between FOXO1 and mitochondria-related protein in the skeletalmuscle of patients with diabetes. ObesemFOXO1 iKO mice exhibited improved mitochondrial respiratory capacity, which was followed by attenuated insulin resistance, enhanced fatty acid oxidation, and improved skeletal muscle exercise capacity. Transcriptional inhibition of FOXO1 in peroxisome proliferator-activated receptor delta (PPAR delta) expression was confirmed in skeletal muscle, and deletion of PPAR delta abolished the beneficial effects of FOXO1 deficiency. FOXO1 protein levels were higher in the skeletal muscle of patients with diabetes and negatively correlated with PPAR delta and electron transport chain protein levels. These findings highlight FOXO1 as a new repressor in PPAR delta gene expression in skeletal muscle and suggest that FOXO1 links insulin resistance andmitochondrial dysfunction in skeletalmuscle via PPAR delta. | Park, Soyoung; Cha, Hye-Na; Shin, Min-Gyeong; Park, Sanghee; Kim, Yeongmin; Kim, Min-Seob; Shin, Kyung-Hoon; Thoudam, Themis; Lee, Eun Ju; Wolfe, Robert R.; Dan, Jinmyoung; Koh, Jin-Ho; Kim, Il-Young; Choi, Inho; Lee, In-Kyu; Sung, Hoon-Ki; Park, So-Young | Yeungnam Univ, Coll Med, Dept Physiol, Daegu, South Korea; Yeungnam Univ, Coll Med, Senotherapy Based Metab Dis Control Res Ctr, Daegu, South Korea; Gachon Univ, Coll Med, Dept Mol Med, Incheon, South Korea; Gachon Univ, Gachon Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Incheon, South Korea; Natl Inst Environm Res, Environm Measurement & Anal Ctr, Dept Fundamental Environm Res, Incheon, South Korea; Hanyang Univ, Dept Marine Sci & Convergent Technol, Ansan, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu, South Korea; Yeungnam Univ, Dept Med Biotechnol, Gyongsan, South Korea; Univ Arkansas Med Sci, Dept Geriatr, Little Rock, AR USA; CHA Univ, Coll Med, Dept Orthoped Surg, Gumi, South Korea; Yonsei Univ, Wonju Coll Med, Dept Convergence Med, Wonju, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Univ Toronto, Hosp Sick Children Res Inst, Toronto, ON, Canada; Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada | Koh, Jin-Ho/AAM-5764-2020; thoudam, themis/ACM-3919-2022; Park, So-Young/AAC-5528-2022 | 57205434058; 28267568200; 57210817848; 57209683110; 57221421587; 36087467600; 57201420612; 57192905626; 57223272919; 57202725354; 24280915900; 56465389500; 56395786700; 56406839400; 36071537600; 26659259100 | sypark@med.yu.ac.kr; | DIABETES | DIABETES | 0012-1797 | 1939-327X | 73 | 7 | SCIE | ENDOCRINOLOGY & METABOLISM | 2024 | 7.5 | 8.6 | 1.04 | 2025-05-07 | 1 | 2 | ACTIVATED-RECEPTOR DELTA; SKELETAL-MUSCLE; OXIDATIVE STRESS; METABOLISM; OBESITY; GENES; BETA; MICE; BIOGENESIS; DISRUPTION | Animals; Diet, High-Fat; Forkhead Box Protein O1; Humans; Insulin Resistance; Male; Mice; Mice, Knockout; Mitochondria; Mitochondria, Muscle; Muscle, Skeletal; Obesity; PPAR delta; peroxisome proliferator activated receptor delta; transcription factor FKHR; FOXO1 protein, human; Foxo1 protein, mouse; peroxisome proliferator activated receptor delta; transcription factor FKHR; animal cell; animal experiment; animal tissue; Article; controlled study; disorders of mitochondrial functions; energy metabolism; exercise; fatty acid oxidation; gene expression; human; insulin resistance; insulin sensitivity; knockout mouse; lipid diet; mitochondrion; mouse; muscle exercise; muscle growth; nonhuman; obesity; protein expression; respiratory chain; skeletal muscle; animal; genetics; knockout mouse; male; metabolism; muscle mitochondrion; physiology; skeletal muscle | English | 2024 | 2024-07 | 10.2337/db23-0432 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Jasmonate activates secondary cell wall biosynthesis through MYC2-MYB46 module | Formation of secondary cell wall (SCW) is tightly regulated spatiotemporally by various developmental and environmental signals. Successful fine-tuning of the trade-off between SCW biosynthesis and stress responses requires a better understanding of how plant growth is regulated under environmental stress conditions. However, the current understanding of the interplay between environmental signaling and SCW formation is limited. The lipid-derived plant hormone jasmonate (JA) and its derivatives are important signaling components involved in various physiological processes including plant growth, development, and abiotic/biotic stress responses. Recent studies suggest that JA is involved in SCW formation but the signaling pathway has not been studied for how JA regulates SCW formation. We tested this hypothesis using the transcription factor MYB46, a master switch for SCW biosynthesis, and JA treatments. Both the transcript and protein levels of MYB46, a master switch for SCW formation, were significantly increased by JA treatment, resulting in the upregulation of SCW biosynthesis. We then show that this JA-induced upregulation of MYB46 is mediated by MYC2, a central regulator of JA signaling, which binds to the promoter of MYB46. We conclude that this MYC2-MYB46 module is a key component of the plant response to JA in SCW formation. | Im, Jong Hee; Son, Seungmin; Kim, Won-Chan; Kim, Kihwan; Mitsuda, Nobutaka; Ko, Jae-Heung; Han, Kyung-Hwan | Michigan State Univ, Dept Hort, E Lansing, MI 48824 USA; Michigan State Univ, DOE Great Lakes Bioenergy Res Ctr, E Lansing, MI 48824 USA; Jeju Natl Univ, Dept Sci Educ, Jeju, South Korea; Rural Dev Adm, Natl Inst Agr Sci, Jeonju 54874, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Natl Inst Adv Ind Sci & Technol, Bioprod Res Inst, Tsukuba, 3058566, Japan; Kyung Hee Univ, Dept Plant & Environm New Resources, Yongin 17104, South Korea; Michigan State Univ, Dept Forestry, E Lansing, MI 48824 USA | ; Han, Kyung-Hwan/G-6141-2012; Mitsuda, Nobutaka/I-6646-2018; Ko, Jae-Heung/A-3370-2013; Son, Seungmin/HPG-7193-2023 | 57210800548; 57219332606; 55492085000; 57210357476; 7005815622; 7402678816; 7402963224 | jhko@khu.ac.kr;hanky@msu.edu; | PLANT JOURNAL | PLANT J | 0960-7412 | 1365-313X | 117 | 4 | SCIE | PLANT SCIENCES | 2024 | 5.7 | 8.6 | 3.39 | 2025-05-07 | 11 | 11 | environmental signaling; jasmonate; MYB46; MYC2; secondary cell wall | RESPONSIVE GENE-EXPRESSION; TRANSCRIPTION FACTOR; LIGNIN BIOSYNTHESIS; LEAF SENESCENCE; DIRECT TARGET; SWITCHES; COMPLEX; STRESS; SND1; MYC2 | environmental signaling; jasmonate; MYB46; MYC2; secondary cell wall | Biochemistry; Biosynthesis; Formation; Growth; Physiology; Plants; Stresses; Walls; Arabidopsis; Arabidopsis Proteins; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Wall; Cyclopentanes; Gene Expression Regulation, Plant; Oxylipins; Transcription Factors; Biochemistry; Biosynthesis; Cell signaling; Economic and social effects; Physiological models; Physiology; Plants (botany); Transcription; Arabidopsis protein; basic helix loop helix leucine zipper transcription factor; cyclopentane derivative; jasmonic acid; MYC2 protein, Arabidopsis; oxylipin; transcription factor; Cell wall biosynthesis; Cell-wall formation; Environmental signaling; Jasmonates; MYB46; MYC2; Plant growth; Secondary cell wall; Stresses response; Up-regulation; Arabidopsis; cell wall; gene expression regulation; genetics; metabolism; Signaling | English | 2024 | 2024-02 | 10.1111/tpj.16541 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Redundant role of OSCNGC4 and OSCNGC5 encoding cyclic nucleotide-gated channels in rice pollen germination and tube growth | In staple crops, such as rice ( Oryza sativa L.), pollen plays a crucial role in seed production. However, the molecular mechanisms underlying rice pollen germination and tube growth remain underexplored. Notably, we recently uncovered the redundant expression and mutual interaction of two rice genes encoding cyclic nucleotide -gated channels (CNGCs), OsCNGC4 and OsCNGC5 , in mature pollen. Building on these findings, the current study focused on clarifying the functional roles of these two genes in pollen germination and tube growth. To overcome functional redundancy, we produced gene -edited rice plants with mutations in both genes using the CRISPR - Cas9 system . T he resulting homozygous OsCNGC4 and OsCNGC5 gene -edited mutants ( oscngc4/ 5 ) exhibited significantly lower pollen germination rates than the wild type (WT), along with severely reduced fertility. Transcriptome analysis of the double oscngc4/5 mutant revealed downregulation of genes related to receptor kinases, transporters, and cell wall metabolism. To identify the direct regulators of OsCNGC4 , which form a heterodimer with OsCNGC5 , we screened a yeast two -hybrid library containing rice cDNAs from mature anthers. Subsequently, we identified two calmodulin isoforms (CaM1-1 and CaM1-2), NETWORKED 2 A (NET2A), and proline-rich extension -like receptor kinase 13 (PERK13) proteins as interactors of OsCNGC4, suggesting its roles in regulating Ca 2 + channel activity and F -actin organization. Overall, our results suggest that OsCNGC4 and OsCNGC5 may play critical roles in pollen germination and elongation by regulating the Ca 2 + gradient in growing pollen tubes. | Kim, Eun Young; Kim, Myung-Hee; Yun, Sang Dae; Lee, Su-Kyoung; Kim, Eui-Jung; Kim, Ji-Hyun; Oh, Sung-Aeong; Kim, Yu-Jin; Jung, Ki-Hong; Park, Soon Ki | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Rural Dev Adm, Natl Inst Agr Sci, Genom Div, Dept Agr Bioresources, Jeonju 54874, South Korea; Kyung Hee Univ, Grad Sch Green Biosci, Yongin 17104, South Korea; Kyung Hee Univ, Crop Biotech Inst, Yongin 17104, South Korea; Pusan Natl Univ, Dept Life Sci & Environm Biochem, Miryang 50463, South Korea | ; Jung, Ki/L-5570-2019; Kim, Jeannie/ACE-1786-2022; Kim, YuJin/NQE-8241-2025 | 58353459000; 57221718078; 57210883667; 57223132353; 57214231436; 59642475200; 7404104444; 57074286200; 56022522000; 8055974900 | khjung2010@khu.ac.kr;psk@knu.ac.kr; | PLANT PHYSIOLOGY AND BIOCHEMISTRY | PLANT PHYSIOL BIOCH | 0981-9428 | 1873-2690 | 208 | SCIE | PLANT SCIENCES | 2024 | 5.7 | 8.6 | 1.55 | 2025-05-07 | 3 | 2 | CA2+ CHANNEL; EXPRESSION; PROTEIN; GENE; CALMODULIN; FAMILY; GMP | Calmodulin; Cyclic Nucleotide-Gated Cation Channels; Germination; Nucleotides, Cyclic; Oryza; Phosphotransferases; Pollen; Pollen Tube; calmodulin; cyclic nucleotide; cyclic nucleotide gated channel; phosphotransferase; genetics; germination; metabolism; Oryza; physiology; pollen; pollen tube | English | 2024 | 2024-03 | 10.1016/j.plaphy.2024.108522 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Research advances of coloring mechanism regulated by MicroRNAs in plants | In plants, microRNAs (miRNAs) are a class of important small RNAs involved in their growth and development, and play a very significant role in regulating their tissue coloring. In this paper, the mechanisms on miRNA regulation of plant coloring are mainly reviewed from three aspects: macroscopic physiological and molecular foundations related to tissue coloring, miRNA biosynthesis and function, and specific analysis of miRNA regulation studies on leaf color, flower color, fruit color, and other tissue color formation in plants. Furthermore, we also systematically summarize the miRNA regulatory mechanisms identified on pigments biosynthesis and color formation in plants, and the regulatory mechanisms of these miRNAs mentioned on the existing researches can be divided into four main categories: directly targeting the related transcription factors, directly targeting the related structural genes, directly targeting the related long noncoding RNAs (LncRNAs) and miRNA-mediated production of trans-acting small interfering RNAs (ta-siRNAs). Together, these research results aim to provide a theoretical reference for the in-depth study of plant coloring mechanism and molecular breeding study of related plants in the future. | Zhang, Xinpeng; Cheng, Lizhen; Shang, Hong; Chen, Qiang; Lu, Mei; Mu, Deyu; Li, Xiaoyan; Meng, Xiang; Wu, Yawei; Han, Xin; Liu, Daliang; Xu, Yanfang | Shandong Jianzhu Univ, Landscape Architecture Res Ctr, Jinan 250101, Peoples R China; Qilu Pharmaceut Co Ltd, Jinan 250101, Peoples R China; Kyungpook Natl Univ, Daegu 41566, South Korea | ; chen, qiang/JXY-6982-2024 | 57199152378; 59254769700; 59253876200; 57904694600; 59254921600; 57190386075; 58611398800; 57884418200; 59254921700; 59254480700; 57929165900; 57221775922 | liudaliang@sdjzu.edu.cn;xyf1979@sdjzu.edu.cn; | PLANT PHYSIOLOGY AND BIOCHEMISTRY | PLANT PHYSIOL BIOCH | 0981-9428 | 1873-2690 | 215 | SCIE | PLANT SCIENCES | 2024 | 5.7 | 8.6 | 0.81 | 2025-05-07 | 4 | 4 | miRNA; Coloring mechanism; Gene regulation; Plant pigments | ANTHOCYANIN ACCUMULATION; FLOWER COLOR; IDENTIFICATION; BIOSYNTHESIS; TRANSCRIPTION; NETWORK; PATHWAY; LIGHT; RNAS; L. | Coloring mechanism; Gene regulation; miRNA; Plant pigments | Flowers; Gene Expression Regulation, Plant; MicroRNAs; Pigmentation; Plant Leaves; Plants; RNA, Plant; microRNA; plant RNA; flower; gene expression regulation; genetics; metabolism; pigmentation; plant; plant leaf | English | 2024 | 2024-10 | 10.1016/j.plaphy.2024.109036 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Cell chip device for real-time monitoring of drug release from drug-laden microparticles | A cell chip is a microfluidic cell culture device fabricated using microchip manufacturing methods for culturing living cells in a micrometer-sized chamber to model the physiological functions of tissues and organs. It has been extensively investigated in the domain of drug transport and toxicity research. Herein, we developed a cell chip for real-time monitoring of drug release from drug carriers. The proposed system integrates three core functions: cell culture, real-time analysis, and drug delivery tests. This device was designed to be loaded with microparticles for drug release and to enable real-time drug measurement. The efficacy of the developed system was evaluated by measuring the concentration of drugs released from the microparticles prepared with poly(lactic-co-glycolic acid) (PLGA). Doxorubicin, an anticancer drug, was used as a model drug and A549 cells, a type of lung cancer cell, were simultaneously cultured to compare the drug release concentrations in the presence of cells. Furthermore, variations in cell viability with respect to the presence of drug-loaded microparticles were observed and analyzed. Notably, as the proposed system requires an extremely small number of microparticles, it affords simple implementation in a single device, thereby eliminating the need for complex accessories and instruments for analysis. Thus, the analysis process becomes more convenient and cost-efficient. Thus, the proposed method offers an easy analysis of the release behavior of various cells and drugs. The simplicity and low cost of this innovative system without sacrificing analytical precision demonstrate its potential for applications across various fields. A cell chip for real-time monitoring of drug release from drug carriers is developed, which integrates three core functions: cell culture, real-time analysis, and drug delivery tests. | Choi, Hye Jin; Shin, Min Chul; Han, Ji Hwan; Kim, Gyu Man | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea | Shin, Min/AAU-6206-2021 | gyuman.kim@knu.ac.kr; | LAB ON A CHIP | LAB CHIP | 1473-0197 | 1473-0189 | 24 | 2 | SCIE | BIOCHEMICAL RESEARCH METHODS;CHEMISTRY, ANALYTICAL;CHEMISTRY, MULTIDISCIPLINARY;INSTRUMENTS & INSTRUMENTATION;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 5.4 | 8.7 | 2 | MICROFLUIDIC TECHNOLOGIES; DELIVERY; FABRICATION; SYSTEMS | English | 2024 | 2024-01-17 | 10.1039/d3lc00798g | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: