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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | North Ecliptic Pole merging galaxy catalogue | Aims. We aim to generate a catalogue of merging galaxies within the 5.4 sq. deg. North Ecliptic Pole over the redshift range 0.0 < z < 0.3. To do this, imaging data from the Hyper Suprime-Cam are used along with morphological parameters derived from these same data. Methods. The catalogue was generated using a hybrid approach. Two neural networks were trained to perform binary merger non-merger classifications: one for galaxies with z < 0.15 and another for 0.15 < z < 0.30. Each network used the image and morphological parameters of a galaxy as input. The galaxies that were identified as merger candidates by the network were then visually checked by experts. The resulting mergers will be used to calculate the merger fraction as a function of redshift and compared with literature results. Results. We found that 86.3% of galaxy mergers at z < 0.15 and 79.0% of mergers at 0.15 < z < 0.30 are expected to be correctly identified by the networks. Of the 34 264 galaxies classified by the neural networks, 10 195 were found to be merger candidates. Of these, 2109 were visually identified to be merging galaxies. We find that the merger fraction increases with redshift, consistent with literature results from observations and simulations, and that there is a mild star-formation rate enhancement in the merger population of a factor of 1.102 +/- 0.084. | Pearson, W. J.; Suelves, L. E.; Ho, S. C-C; Oi, N.; Brough, S.; Holwerda, B. W.; Hopkins, A. M.; Huang, T-C; Hwang, H. S.; Kelvin, L. S.; Kim, S. J.; Lopez-Sanchez, A. R.; Malek, K.; Pearson, C.; Poliszczuk, A.; Pollo, A.; Rodriguez-Gomez, V; Shim, H.; Toba, Y.; Wang, L. | Natl Ctr Nucl Res, Pasteura 7, PL-02093 Warsaw, Poland; Natl Tsing Hua Univ, Inst Astron, 101,Sect 2 Kuang Fu Rd, Hsinchu 30013, Taiwan; Tokyo Univ Sci, Fac Sci, Div 2, Liberal Arts,Shinjuku Ku, 1-3 Kagurazaka, Tokyo 1628601, Japan; Univ New South Wales, Sch Phys, Sydney, NSW 2052, Australia; Univ Louisville, Dept Phys & Astron, 102 Nat Sci Bldg, Louisville, KY 40292 USA; Macquarie Univ, Australian Astron Opt, 105 Delhi Rd, N Ryde, NSW 2113, Australia; Grad Univ Adv Studies, SOKENDAI, Dept Space & Astronaut Sci, Miura Dist, Kanagawa 2400193, Japan; Japan Aerosp Explorat Agcy, Inst Space & Astronaut Sci, Chuo Ku, 3-1-1 Yoshinodai, Sagamihara, Kanagawa 2525210, Japan; Seoul Natl Univ, Dept Phys & Astron, Astron Program, 1 Gwanak Ro, Seoul 08826, South Korea; Princeton Univ, Dept Astrophys Sci, 4 Ivy Lane, Princeton, NJ 08544 USA; Macquarie Univ, Dept Phys & Astron, Sydney, NSW 2109, Australia; ARC Ctr Excellence All Sky Astrophys 3 Dimens AST, Sydney, NSW, Australia; Aix Marseille Univ, CNRS, CNES, LAM, Marseille, France; Open Univ, Milton Keynes MK7 6AA, Bucks, England; Rutherford Appleton Lab, RAL Space, Didcot OX11 0QX, Oxon, England; Univ Oxford, Oxford Astrophys, Keble Rd, Oxford OX1 3RH, England; Univ Nacl Autonoma Mexico, Inst Radioastron & Astrofis, AP 72-3, Morelia 58089, Michoacan, Mexico; Kyungpook Natl Univ, Dept Earth Sci Educ, Daegu 41566, South Korea; Kyoto Univ, Dept Astron, Sakyo Ku, Kitashirakawa Oiwake Cho, Kyoto 6068502, Japan; Acad Sinica, Inst Astron & Astrophys, AS NTU, 11F Astron Math Bldg,1,Sect 4,Roosevelt Rd, Taipei 10617, Taiwan; Ehime Univ, Res Ctr Space & Cosm Evolut, 2-5 Bunkyo Cho, Matsuyama, Ehime 7908577, Japan; SRON Netherlands Inst Space Res, Landleven 12, NL-9747 AD Groningen, Netherlands; Univ Groningen, Kapteyn Astron Inst, Postbus 800, NL-9700 AV Groningen, Netherlands | ; Rodríguez, Roberto/L-6009-2014; Lopez-Sanchez, Angel/F-8164-2018; Hopkins, Andrew/KBC-5515-2024; López-Sánchez, Ángel Rafael/ISU-0126-2023; MAŁEK, KATARZYNA/A-1254-2012; Shim, Hyunjin/LZI-7486-2025; Huang, Teddy/ABB-7532-2020; Wang, Lingyu/HCI-0415-2022; HWANG, Ho/AAS-6010-2020 | 57195032075; 57479401900; 57216812477; 23968436800; 56277113400; 9942710000; 7102307434; 57203623570; 15131707100; 35743168200; 57070819300; 12806470600; 57700187200; 55531949600; 57192100278; 56234075800; 55916180400; 14061137700; 37068332400; 36238621200 | william.pearson@ncbj.gov.pl; | ASTRONOMY & ASTROPHYSICS | ASTRON ASTROPHYS | 0004-6361 | 1432-0746 | 661 | SCIE | ASTRONOMY & ASTROPHYSICS | 2022 | 6.5 | 12.3 | 1.76 | 2025-06-25 | 22 | 21 | catalogs; galaxies: interactions; galaxies: evolution; methods: data analysis; galaxies: statistics | DIGITAL SKY SURVEY; STAR-FORMING GALAXIES; MASS ASSEMBLY GAMA; ACTIVE GALACTIC NUCLEI; LESS-THAN 2; MERGER RATES; ILLUSTRISTNG SIMULATIONS; INTERACTING GALAXIES; DISTANT GALAXIES; FIELD GALAXIES | Catalogs; Galaxies: evolution; Galaxies: interactions; Galaxies: statistics; Methods: data analysis | Galaxies; Poles; Catalog; Galaxies: interactions; Galaxies: statistics; Galaxy evolution; Imaging data; Methods. Data analysis; Morphological parameters; Neural-networks; Red shift; Redshift range; Merging | English | 2022 | 2022-05-17 | 10.1051/0004-6361/202141013 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Search for exoplanets around northern circumpolar stars V. Three likely planetary companions to the giant stars HD 19615, HD 150010, and HD 174205 | Aims. We report the detection of long-period radial velocity (RV) variations in three giant stars, HD 19615, HD 150010, and HD 174205, using precise RV measurements. Methods. These detections are part of the Search for Exoplanets around Northern Circumpolar Stars (SENS) survey being conducted at the Bohyunsan Optical Astronomy Observatory (BOAO). The nature of the RV variations was investigated by analyzing the photometric and line shape variations. We found no variability with the RV period in these quantities and conclude that the RV variations are most likely caused by planetary companions. Results. Orbital solutions for the three stars yield orbital periods of 402 d, 562 d, and 582 d and minimum masses of 8.5 M-J, 2.4 M-J, and 4.2 M-J, respectively. These masses and periods are typical for planets around intermediate-mass stars, although some unclear interpretations and recent studies may being calling some planet convictions into question. Nevertheless, the SENS program is contributing to our knowledge of giant planets around intermediate-mass stars. | Jeong, G.; Lee, B. -C.; Park, M. -G.; Bang, T. -Y.; Han, I. | Antbridge Technol, 101 Gajeong ro, Daejeon 34120, South Korea; Korea Astron & Space Sci Inst, 776 Daedeokdae Ro, Daejeon 34055, South Korea; Korea Univ Sci & Technol, Gajeong ro, Daejeon 34113, South Korea; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 41566, South Korea | 56152551500; 8878262900; 7404490321; 57201317966; 7201559866 | tlotv1@gmail.com;bclee@kasi.re.kr;iwhan@kasi.re.kr; | ASTRONOMY & ASTROPHYSICS | ASTRON ASTROPHYS | 0004-6361 | 1432-0746 | 662 | SCIE | ASTRONOMY & ASTROPHYSICS | 2022 | 6.5 | 12.3 | 0.08 | 2025-06-25 | 1 | 1 | techniques; radial velocities; planetary systems; stars; individual; HD 19615; stars; individual; HD 150010; stars; individual; HD 174205 | PRECISE RADIAL-VELOCITIES; ATMOSPHERIC PARAMETERS; CHROMOSPHERIC ACTIVITY; MASS OUTFLOW; K DWARFS; ISOCHRONES; VARIABILITY; TRACKS | Planetary systems; Stars: individual: HD 150010; Stars: individual: HD 174205; Stars: individual: HD 19615; Techniques: radial velocities | Giant stars; Orbits; Exo-planets; Planetary system; Radial velocity; Star: individual: HD 150010; Star: individual: HD 174205; Star: individual: HD 19615; Stars: individual: proxima Centauri; Techniques: radial velocities; Extrasolar planets | English | 2022 | 2022-05-31 | 10.1051/0004-6361/202142379 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Stellar masses, sizes, and radial profiles for 465 nearby early-type galaxies: An extension to the Spitzer survey of stellar structure in Galaxies (S⁴G) | Context. The Spitzer Survey of Stellar Structure in Galaxies (S(4)G) is a detailed study of over 2300 nearby galaxies in the near-infrared (NIR), which has been critical to our understanding of the detailed structures of nearby galaxies. Because the sample galaxies were selected only using radio-derived velocities, however, the survey favored late-type disk galaxies over lenticulars and ellipticals. Aims. A follow-up Spitzer survey was conducted to rectify this bias, adding 465 early-type galaxies (ETGs) to the original sample, to be analyzed in a manner consistent with the initial survey. We present the data release of this ETG extension, up to the third data processing pipeline (P3): surface photometry. Methods. We produce curves of growth and radial surface brightness profiles (with and without inclination corrections) using reduced and masked Spitzer IRAC 3.6 mu m and 4.5 mu m images produced through Pipelines 1 and 2, respectively. From these profiles, we derive the following integrated quantities: total magnitudes, stellar masses, concentration parameters, and galaxy size metrics. We showcase NIR scaling relations for ETGs among these quantities. Results. We examine general trends across the whole S(4)G and ETG extension among our derived parameters, highlighting differences between ETGs and late-type galaxies (LTGs). The latter are, on average, more massive and more concentrated than LTGs, and subtle distinctions are seen among ETG morphological subtypes. We also derive the following scaling relations and compare them with previous results in visible light: mass-size (both half-light and isophotal), mass-concentration, mass-surface brightness (central, effective, and within 1 kpc), and mass-color. Conclusions. We find good agreement with previous works, though some relations (e.g., mass-central surface brightness) will require more careful multicomponent decompositions to be fully understood. The relations between mass and isophotal radius and between mass and surface brightness within 1 kpc, in particular, show notably small scatter. The former provides important constraints on the limits of size growth in galaxies, possibly related to star formation thresholds, while the latter-particularly when paired with the similarly tight relation for LTGs-showcases the striking self-similarity of galaxy cores, suggesting they evolve little over cosmic time. All of the profiles and parameters described in this paper will be provided to the community via the NASA/IPAC database on a dedicated website. | Watkins, A. E.; Salo, H.; Laurikainen, E.; Diaz-Garcia, S.; Comeron, S.; Janz, J.; Su, A. H.; Buta, R.; Athanassoula, E.; Bosma, A.; Ho, L. C.; Holwerda, B. W.; Kim, T.; Knapen, J. H.; Laine, S.; Menendez-Delmestre, K.; Peletier, R. F.; Sheth, K.; Zaritsky, D. | Univ Oulu, Space Phys & Astron Res Unit, Oulu 90014, Finland; Univ Hertfordshire, Sch Phys Astron & Math, Ctr Astrophys Res, Hatfield AL10 9AB, Herts, England; Liverpool John Moores Univ, Astrophys Res Inst, IC2,Liverpool Sci Pk,146 Brownlow Hill, Liverpool L3 5RF, England; Univ Turku, Finnish Ctr Astron ESO FINCA, Vesilinnantie 5, Turku 20014, Finland; Spectral Imaging Ltd, Specim, Elektroniikkatie 13, Oulu, Finland; Univ La Laguna, Dept Astrofis, San Cristobal la Laguna 38200, Tenerife, Spain; Inst Astrofis Canarias, Tenerife 38205, Spain; Queens Univ, Dept Phys Engn Phys & Astrophys, Kingston, ON K7L 3N6, Canada; Univ Alabama, Dept Phys & Astron, POB 870324, Tuscaloosa, AL 35487 USA; Aix Marseille Univ, CNRS, CNES, LAM, Marseille, France; Peking Univ, Kavli Inst Astron & Astrophys, Beijing 100871, Peoples R China; Peking Univ, Sch Phys, Dept Astron, Beijing, Peoples R China; Univ Louisville, Dept Phys & Astron, 102 Nat Sci Bldg, Louisville, KY 40292 USA; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 41566, South Korea; CALTECH, IPAC, Mail Code 314-6,1200 E Calif Blvd, Pasadena, CA 91125 USA; Fed Univ Rio Janeiro, Valongo Observ, Ladeira Pedro Antonio 43, BR-20080090 Rio De Janeiro, RJ, Brazil; Univ Groningen, Kapteyn Astron Inst, POB 800, NL-9700 Groningen, Netherlands; NASA, Headquarters Mary W Jackson Bldg,300 St SW, Washington, DC 20546 USA; Univ Arizona, Steward Observ & Dept Astron, 933 N Cherry Ave, Tucson, AZ 85721 USA | Knapen, Johan/Z-4828-2019; Zaritsky, Dennis/KIC-9898-2024; Menendez-Delmestre, Karin/E-3266-2013; Bosma, Albert/KCY-7063-2024; Díaz-García, Simón/AAA-9165-2020; Peletier, Reynier/B-9633-2012; Comeron, Sebastien/F-4841-2016 | 43361925900; 7006602228; 35589174400; 55868973400; 35748477600; 26435215300; 57222071183; 7004882830; 7003637810; 56213655300; 57225302746; 9942710000; 57050549000; 7005317106; 7005926335; 8881788000; 7006440295; 35228008300; 7004884588 | a.emery.watkins@gmail.com; | ASTRONOMY & ASTROPHYSICS | ASTRON ASTROPHYS | 0004-6361 | 1432-0746 | 660 | SCIE | ASTRONOMY & ASTROPHYSICS | 2022 | 6.5 | 12.3 | 1.09 | 2025-06-25 | 23 | 13 | galaxies: evolution; galaxies: photometry; galaxies: elliptical and lenticular, cD; galaxies: structure; galaxies: statistics; galaxies: spiral | CCD SURFACE PHOTOMETRY; HUBBLE-SPACE-TELESCOPE; HIGH-REDSHIFT GALAXIES; INFRARED ARRAY CAMERA; VIRGO-CLUSTER SURVEY; EDGE-ON GALAXIES; ELLIPTIC GALAXIES; SCALING RELATIONS; STAR-FORMATION; FUNDAMENTAL PLANE | Cd; Galaxies: Elliptical and lenticular; Galaxies: Evolution; Galaxies: Photometry; Galaxies: Spiral; Galaxies: Statistics; Galaxies: Structure | Data handling; Infrared devices; Light; Luminance; Photometry; Pipelines; Stars; Surveys; Cd; Early types; Galaxies: elliptical and lenticular; Galaxies: photometry; Galaxies: spirals; Galaxies: statistics; Galaxies:structure; Galaxy evolution; Late-type; Spitzer; Galaxies | English | 2022 | 2022-04-13 | 10.1051/0004-6361/202142627 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Abscisic acid, carbohydrate, and Glucosinolate metabolite profiles in Kimchi cabbage treated with extremely high temperatures and chitosan foliar application | Chitosan can help enhance disease resistance in plants by thickening leaves and alleviating environmental stresses, such as excess light intensity and extremely high temperature by promoting physiological activity. This study evaluated the effects of chitosan foliar application on Kimchi cabbage under high temperature stress. Six treatments were conducted, combining three photo-/dark periods temperature levels (20/16 degrees C optimal; 28/ 24 degrees C moderately high; and 36/32 degrees C extremely high) with and without chitosan foliar application (0 and 200 mg center dot L - 1). Chitosan foliar application treatment sprayed once at 42 days after transplanting, and then temperature treatment immediately after chitosan foliar application conducted for up to eight days. At eight days after treatment (DAT), the leaf contents of abscisic acid (ABA) metabolites, i.e., phaseic acid (PA), dihydrophaseic acid (DPA), and ABA glucose ester (ABA-GE), were higher with chitosan foliar application than without chitosan treatments under moderately high and extremely high temperature conditions. PA and DPA were present at higher levels than the other metabolites. At eight DAT, the glucose and fructose contents in Kimchi cabbage treated with chitosan foliar application were higher than in those without chitosan foliar application when plants were under the moderately high and extremely high temperature conditions. Glucosinolate metabolite (gluconapin, glucobrassicanapin, glucobrassicin, and 4-methoxyglucobrassicin) content was higher with chitosan foliar application than without chitosan foliar application under the extremely high temperature treatment. When exposed to extremely high temperature, chitosan foliar application mitigated the damage caused to Kimchi cabbage by high temperature stress. Overall, chitosan foliar application can alleviate the high temperature stress that can occur during the spring cultivation season in Kimchi cabbage, and the application of chitosan is therefore a feasible strategy for stabilizing production of Kimchi cabbage. | Sim, Ha Seon; Jo, Jung Su; Woo, Ui Jeong; Jo, Won Jun; Moon, Yu Hyun; Lee, Jun Gu; Lee, Hee Ju; Wi, Seung Hwan; Kim, Sung Kyeom | Kyungpook Natl Univ, Coll Agr & Sci, Dept Hort Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Jeonbuk Natl Univ, Coll Agr & Life Sci, Dept Hort, Jeonju 54896, South Korea; Natl Inst Hort & Herbal Sci, Vegetable Res Div, Wonju 55365, South Korea | ; Kim, Sung Kyeom/AAD-9230-2019 | 57807906000; 57807277100; 57806954500; 57806954600; 57807429600; 57806790500; 57211437441; 57209459643; 57807120200 | skkim76@knu.ac.kr; | SCIENTIA HORTICULTURAE | SCI HORTIC-AMSTERDAM | 0304-4238 | 1879-1018 | 304 | SCIE | HORTICULTURE | 2022 | 4.3 | 12.5 | 1.4 | 2025-06-25 | 10 | 11 | ABA metabolite; Biostimulant; Brassica rapa L; ssp; pekinensis; High temperature stress; Phytochemical | REACTIVE OXYGEN; ABIOTIC STRESS; HEAT-STRESS; DROUGHT; ABA; GROWTH; PLANT; CELL; L.; COMBINATION | ABA metabolite; Biostimulant; Brassica rapa L. ssp. pekinensis; High temperature stress; Phytochemical | disease resistance | English | 2022 | 2022-10-15 | 10.1016/j.scienta.2022.111311 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Anti-inflammatory activity and cytotoxicity against ovarian cancer cell lines by amide alkaloids and piperic esters isolated from Piper longum fruits: In vitro assessments and molecular simulation | Three new amide alkaloids, piperlongumamides D-F (14 , 19 , and 32); a new piperic ester, piperlongumester A (45); and two new natural compounds, methyl (2E,4Z)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate (46) and trans-piperolein B ester (47), along with 41 known compounds were isolated from the fruits of Piper longum L. Their structures were identified by analyzing spectroscopic data, including mass spectrometry, 1D, and 2D NMR data. The anti-inflammatory and cytotoxic activities of all isolated compounds (1-47) were evaluated. Com-pounds 3 , 6 , and 19 inhibited nitric oxide production with IC50 values of 16.1 +/- 0.94, 14.5 +/- 0.57, and 27.3 +/- 1.11 mu M, respectively, whereas compound 1 exhibited strong cytotoxic activity toward three ovarian cancer cell lines A2780, TOV-112D, and SK-OV3, with IC50 values of 6.7 +/- 0.77, 5.8 +/- 0.29, and 48.3 +/- 0.40 mu M, respectively. Molecular docking simulations were performed to identify the interaction and binding mechanisms of these active metabolites with proteins related to inflammation and cancer. | Phong, Nguyen Viet; Anh, Dinh Thi Nguyet; Chae, Ha Yeong; Yang, Seo Young; Kwon, Mi Jeong; Min, Byung Sun; Kim, Jeong Ah | Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr, VOICE MRC, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Pharm & Res Inst Pharmaceut Sci, BK21 FOUR Community Based Intelligent Novel Drug D, Daegu 41566, South Korea; Sangji Univ, Dept Pharmaceut Engn, Wonju 26339, South Korea; Daegu Catholic Univ, Coll Pharm, Drug Res & Dev Ctr, Gyeongbuk 38430, South Korea | Nguyen, Viet Phong/AAQ-4207-2021 | 57205196739; 57861522200; 57860957700; 57215036954; 35278164800; 57195057619; 24722570900 | jkim6923@knu.ac.kr; | BIOORGANIC CHEMISTRY | BIOORG CHEM | 0045-2068 | 1090-2120 | 128 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, ORGANIC | 2022 | 5.1 | 12.5 | 2.08 | 2025-06-25 | 24 | 22 | Piper longum fruits; Amide alkaloid; Anti-inflammatory activity; Ovarian cancer cell lines; Molecular docking | UFLC-ESI-MS/MS; ANTIFUNGAL AMIDES; INHIBITION; DOCKING; NIGRUM; L.; CONSTITUENTS; PIPERLONGUMININE; ALKAMIDES; SYNTHASE | Amide alkaloid; Anti-inflammatory activity; Molecular docking; Ovarian cancer cell lines; Piper longum fruits | Alkaloids; Amides; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Esters; Female; Fruit; Humans; Molecular Docking Simulation; Molecular Structure; Ovarian Neoplasms; Piper; alkaloid derivative; ester derivative; flurbiprofen; nitric oxide; vorinostat; alkaloid; amide; antiinflammatory agent; antineoplastic agent; ester; antiinflammatory activity; Article; binding affinity; binding site; chemical structure; cytotoxicity; electron impact mass spectrometry; IC50; in vitro study; inflammation; mass spectrometry; molecular docking; MTT assay; nonhuman; ovarian cancer cell line; Piper longum; chemistry; female; fruit; human; molecular docking; ovary tumor; Piper (plant); tumor cell line | English | 2022 | 2022-11 | 10.1016/j.bioorg.2022.106072 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses | Although levodopa is the most effective medication for Parkinson's disease, long-term levodopa treatment is largely compromised due to late motor complications, including levodopa-induced dyskinesia (LID). However, the genetic basis of LID pathogenesis has not been fully understood. Here, we discover genes pathogenic for LID using Drosophila genetics and behavioral analyses combined with genome-wide association studies on 578 patients clinically diagnosed with LID. Similar to the therapeutic effect of levodopa in patients, acute levodopa treatments restore the motor defect of Parkinson's disease model flies, while prolonged treatments cause LID-related symptoms, such as increased yawing, freezing and abrupt acceleration of locomotion. These symptoms require dopamine 1-like receptor 1 and are induced by neuronal overexpression of the receptor. Among genes selected from our analyses in the patient genome, neuronal knockdown of adenylyl cyclase 2 suppresses the levodopa-induced phenotypes and the receptor overexpression-induced symptoms in Drosophila. Together, our study provides genetic insights for LID pathogenesis through the D1-like receptor-adenylyl cyclase 2 signaling axis. A combined research approach using GWAS on Parkinson's disease patients and a Drosophila model of L-DOPA-induced dyskinesia (LID) reveals that LID is linked to ADCY2 signaling. | Yoon, Woongchang; Min, Soohong; Ryu, Ho-Sung; Chung, Sun Ju; Chung, Jongkyeong | Seoul Natl Univ, Sch Biol Sci, 1 Gwanak Ro, Seoul 08826, South Korea; Seoul Natl Univ, Inst Mol Biol & Genet, 1 Gwanak Ro, Seoul 08826, South Korea; Kyungpook Natl Univ Hosp, Dept Neurol, Dongdeok Ro 130, Daegu 41944, South Korea; Univ Ulsan, Asan Med Ctr, Dept Neurol, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Seoul Natl Univ, BioMAX N Bio Inst, 1 Gwanak Ro, Seoul 08826, South Korea; Harvard Med Sch, Dept Cell Biol, 240 Longwood Ave, Boston, MA 02115 USA | 57195565149; 37031642800; 57014206500; 56882955600; 56040953500 | jkc@snu.ac.kr; | COMMUNICATIONS BIOLOGY | COMMUN BIOL | 2399-3642 | 5 | 1 | SCIE | BIOLOGY | 2022 | 5.9 | 12.5 | 0.57 | 2025-06-25 | 4 | 5 | DOPA-INDUCED DYSKINESIA; PARKINSONS-DISEASE; ADENYLYL-CYCLASE; MOLECULAR-MECHANISMS; CLINICAL-FEATURES; MODEL; D1; INHIBITION; DISRUPTION; MODULATION | Animals; Drosophila; Dyskinesia, Drug-Induced; Genome-Wide Association Study; Genomics; Levodopa; Parkinson Disease; levodopa; animal; Drosophila; dyskinesia; genetics; genome-wide association study; genomics; Parkinson disease | English | 2022 | 2022-08-25 | 10.1038/s42003-022-03830-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Human embryonic stem cell-specific role of YAP in maintenance of self-renewal and survival | Human embryonic stem cells (hESCs) have unique characteristics, such as self-renewal and pluripotency, which are distinct from those of other cell types. These characteristics of hESCs are tightly regulated by complex signaling mechanisms. In this study, we demonstrate that yes-associated protein (YAP) functions in an hESC-specific manner to maintain self-renewal and survival in hESCs. hESCs were highly sensitive to YAP downregulation to promote cell survival. Interestingly, hESCs displayed dynamic changes in YAP expression in response to YAP downregulation. YAP was critical for the maintenance of self-renewal. Additionally, the function of YAP in maintenance of self-renewal and cell survival was hESC-specific. Doxycycline upregulated YAP in hESCs and attenuated the decreased cell survival induced by YAP downregulation. However, decreased expression of self-renewal markers triggered by YAP downregulation and neural/cardiac differentiation were affected by doxycycline treatment. Collectively, the results reveal the mechanism underlying the role of YAP and the novel function of doxycycline in hESCs. | Choe, Mu Seog; Bae, Chang Min; Kim, So Jin; Oh, Seung Tack; Kown, Yu Jin; Choi, Won-Young; Han, Ho Jae; Baek, Kyung Min; Chang, Woochul; Kim, Joong Sun; Lim, Kyung Seob; Yun, Seung Pil; Lee, Min Young | Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr VOICE, Res Inst Pharmaceut Sci,MRC, Daegu, South Korea; Seoul Natl Univ, Coll Vet Med, Seoul, South Korea; Daegu Haany Univ, Coll Oriental Med, Daegu, South Korea; Pusan Natl Univ, Coll Educ, Busan, South Korea; Chonnam Natl Univ, Coll Vet Med, Gwangju, South Korea; Korea Res Inst Biosci & Biotechnol, Futurist Anim Resource & Res Ctr, Cheongju, South Korea; Gyeongsang Natl Univ, Coll Med, Jinju, South Korea | Choi, Wonyoung/LMP-4209-2024; Han, Ho/M-1476-2016 | 57202926165; 57211800962; 57224776382; 57321681800; 57924873600; 56147288900; 7401968982; 56421484100; 12797539700; 7601371367; 36470521900; 25951635400; 15119890400 | vetmedic@knu.ac.kr; | CELLULAR AND MOLECULAR LIFE SCIENCES | CELL MOL LIFE SCI | 1420-682X | 1420-9071 | 79 | 11 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2022 | 8 | 12.5 | 0.28 | 2025-06-25 | 4 | 3 | Human embryonic stem cells; Yes-associated protein; Self-renewal; Survival; Doxycycline | HIPPO PATHWAY; SIZE-CONTROL; DOXYCYCLINE; DIFFERENTIATION; EXPANSION; APOPTOSIS; CULTURE; COMPLEX | Doxycycline; Human embryonic stem cells; Self-renewal; Survival; Yes-associated protein | Cell Differentiation; Doxycycline; Human Embryonic Stem Cells; Humans; Signal Transduction; YAP-Signaling Proteins; brachyury T; doxycycline; hepatocyte nuclear factor 3beta; homeobox protein Nkx-2.5; MEF2C protein; nestin; octamer transcription factor 4; transcription factor; transcription factor NANOG; transcription factor PAX6; transcription factor Sox17; transcription factor Sox2; unclassified drug; verteporfin; YAP signaling protein; doxycycline; Article; cell differentiation; cell proliferation; cell self-renewal; cell survival; cell viability; controlled study; down regulation; flow cytometry; gene overexpression; genetic regulation; human; human cell; human embryonic stem cell; immunocytochemistry; protein expression; protein expression level; protein function; protein phosphorylation; upregulation; metabolism; physiology; signal transduction | English | 2022 | 2022-11 | 10.1007/s00018-022-04558-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Hypothalamic inflammation in metabolic disorders and aging | The hypothalamus is a critical brain region for the regulation of energy homeostasis. Over the years, studies on energy metabolism primarily focused on the neuronal component of the hypothalamus. Studies have recently uncovered the vital role of glial cells as an additional player in energy balance regulation. However, their inflammatory activation under metabolic stress condition contributes to various metabolic diseases. The recruitment of monocytes and macrophages in the hypothalamus helps sustain such inflammation and worsens the disease state. Neurons were found to actively participate in hypothalamic inflammatory response by transmitting signals to the surrounding non-neuronal cells. This activation of different cell types in the hypothalamus leads to chronic, low-grade inflammation, impairing energy balance and contributing to defective feeding habits, thermogenesis, and insulin and leptin signaling, eventually leading to metabolic disorders (i.e., diabetes, obesity, and hypertension). The hypothalamus is also responsible for the causation of systemic aging under metabolic stress. A better understanding of the multiple factors contributing to hypothalamic inflammation, the role of the different hypothalamic cells, and their crosstalks may help identify new therapeutic targets. In this review, we focus on the role of glial cells in establishing a cause-effect relationship between hypothalamic inflammation and the development of metabolic diseases. We also cover the role of other cell types and discuss the possibilities and challenges of targeting hypothalamic inflammation as a valid therapeutic approach. | Bhusal, Anup; Rahman, Md Habibur; Suk, Kyoungho | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea; Rutgers Robert Wood Johnson Med Sch, Dept Med, Div Endocrinol, New Brunswick, NJ 08901 USA; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41944, South Korea | Rahman, Md Habibur/HMD-4572-2023 | 57200274141; 59607139800; 7005114595 | ksuk@knu.ac.kr; | CELLULAR AND MOLECULAR LIFE SCIENCES | CELL MOL LIFE SCI | 1420-682X | 1420-9071 | 79 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2022 | 8 | 12.5 | 1.17 | 2025-06-25 | 35 | 31 | Aging; Diabetes; Hypertension; Hypothalamus; Inflammation; Obesity | HIGH-FAT-DIET; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; BLOOD-BRAIN-BARRIER; ENDOPLASMIC-RETICULUM STRESS; INSULIN-RECEPTOR EXPRESSION; SALT-INDUCED HYPERTENSION; PARAVENTRICULAR NUCLEUS; TNF-ALPHA; BODY-WEIGHT | Aging; Diabetes; Hypertension; Hypothalamus; Inflammation; Obesity | Aging; Animals; Disease Models, Animal; Humans; Hypothalamus; Inflammation; Metabolic Diseases; Models, Biological; cell antigen; fatty acid; I kappa B kinase beta; immunoglobulin enhancer binding protein; neuron glial antigen 2; unclassified drug; aging; astrocyte; cell function; cell interaction; cell population; cytokine production; diabetes mellitus; disease association; endothelium cell; energy balance; energy metabolism; gene expression regulation; glia cell; homeostasis; human; hyperglycemia; hypertension; hypothalamic inflammation; hypothalamus disease; insulin resistance; insulin signaling; leptin signaling; low grade inflammation; macrophage; metabolic disorder; microglia; nerve cell; nonhuman; obesity; pathogenesis; protein function; Review; risk factor; signal transduction; tanycyte; aging; animal; biological model; disease model; hypothalamus; inflammation; metabolic disorder; pathology | English | 2022 | 2022-01 | 10.1007/s00018-021-04019-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Matching amino acids membrane preference profile to improve activity of antimicrobial peptides | Canonical helical antimicrobial peptides are less insertive and less active. Here, an improved antimicrobial peptide, WCopWs, indicate that matching amino acids membrane preference profile improves insertion and activity. Antimicrobial peptides (AMPs) are cationic antibiotics that can kill multidrug-resistant bacteria via membrane insertion. However, their weak activity limits their clinical use. Ironically, the cationic charge of AMPs is essential for membrane binding, but it obstructs membrane insertion. In this study, we postulate that this problem can be overcome by locating cationic amino acids at the energetically preferred membrane surface. All amino acids have an energetically preferred or less preferred membrane position profile, and this profile is strongly related to membrane insertion. However, most AMPs do not follow this profile. One exception is protegrin-1, a powerful but neglected AMP. In the present study, we found that a potent AMP, WCopW5, strongly resembles protegrin-1 and that the match between its sequence and the preferred position profile closely correlates with its antimicrobial activity. One of its derivatives, WCopW43, has antimicrobial activity comparable to that of the most effective AMPs in clinical use. | Kim, Shanghyeon; Lee, Jaehoo; Lee, Sol; Kim, Hyein; Sim, Ji-Yeong; Pak, Boryeong; Kim, Kyeongmin; Kim, Jae Il | Gwangju Inst Sci & Technol, Sch Life Sci, Gwangju 61005, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, 680 Gukchaebosangro, Daegu 41944, South Korea; AnyGen, Pilot Plant, Technopk,333 Cheomdangwagiro, Gwangju 61008, South Korea | 57204477515; 57958456000; 57959762500; 57194502342; 36487195600; 57191860855; 57216604095; 35956476300 | jikim@gist.ac.kr; | COMMUNICATIONS BIOLOGY | COMMUN BIOL | 2399-3642 | 5 | 1 | SCIE | BIOLOGY | 2022 | 5.9 | 12.5 | 0.8 | 2025-06-25 | 6 | 7 | RATIONAL COMBINATORIAL DESIGN; DRUG-RESISTANT; ANTIBACTERIAL PEPTIDES; TRYPTOPHAN-RICH; DISULFIDE BONDS; BROAD-SPECTRUM; PROTEGRIN-1; MODEL; MECHANISM; CELL | Adenosine Monophosphate; Amino Acids; Anti-Bacterial Agents; Antimicrobial Peptides; Cations; adenosine phosphate; amino acid; antiinfective agent; cation; polypeptide antibiotic agent | English | 2022 | 2022-11-08 | 10.1038/s42003-022-04164-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Optimization of protocol for efficient protoplast isolation and transient gene expression in carnation | The optimal protocols for protoplast isolation and transfection in carnation cv. Scarlet were developed by optimizing the factors involved in protoplast isolation and transfection processes. The best protoplast yield and viability were achieved using 0.5 M mannitol, enzyme concentrations of 1.0% cellulase and 0.1% macerozyme, and digestion time of 8 h. In contrast, the best transfection efficiency was obtained using protoplast density of 2.5 x 10(5), polyethylene glycol (PEG) concentration of 20%, and transfection time of 15 min. The protocols could produce reasonable protoplast yield and transfection efficiency in other carnations. The transient expression of enhanced green fluorescent protein (eGFP) in the nucleus of the transfected protoplasts of all carnations was confirmed using PCR analysis. To our knowledge, this is the first report on transient gene expression in carnation protoplasts. This transient gene expression system could be valuable for genome editing of unwanted genes in carnations using the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 technology. | Adedeji, Oluwaseun Suleimon; Naing, Aung Htay; Kang, Hyunhee; Chung, Mi Young; Lim, Ki Byung; Kim, Chang Kil | Kyungpook Natl Univ, Dept Hort, Daegu 41566, South Korea; Suncheon Natl Univ, Dept Agr Educ, Sunchon 57922, South Korea | Adedeji, Oluwaseun/IUN-2788-2023; Naing, Aung Htay/AAF-4277-2019 | 57216153720; 37112768100; 57217681910; 24821361600; 7403175915; 7409880701 | ckkim@knu.ac.kr; | SCIENTIA HORTICULTURAE | SCI HORTIC-AMSTERDAM | 0304-4238 | 1879-1018 | 299 | SCIE | HORTICULTURE | 2022 | 4.3 | 12.5 | 1.4 | 2025-06-25 | 12 | 11 | Carnation; eGFP; Protoplast yield; Protoplast viability; Transfection efficiency; PCR analysis | LONG VASE LIFE; PLANT-REGENERATION; MESOPHYLL PROTOPLASTS; SYSTEM; CULTURE; MUTAGENESIS; FLOWERS; L. | Carnation; eGFP; PCR analysis; Protoplast viability; Protoplast yield; Transfection efficiency | chemical reaction; crop yield; enzyme; enzyme activity; gene expression; genome; optimization; protein | English | 2022 | 2022-06-01 | 10.1016/j.scienta.2022.111057 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Adaptive evolution strategy with ensemble of mutations for Reinforcement Learning | Evolving the weights of learning networks through evolutionary computation (neuroevolution) has proven scalable over a range of challenging Reinforcement Learning (RL) control tasks. However, similar to most black-box optimization problems, existing neuroevolution approaches require an additional adaptation process to effectively balance exploration and exploitation through the selection of sensitive hyper-parameters throughout the evolution process. Therefore, these methods are often plagued by the computation complexities of such adaptation processes which often rely on a number of sophisticatedly formulated strategy parameters. In this paper, Evolution Strategy (ES) with a simple yet efficient ensemble of mutation strategies is proposed. Specifically, two distinct mutation strategies coexist throughout the evolution process where each strategy is associated with its own population subset. Consequently, elites for generating a population of offspring are realized by co-evaluation of the combined population. Experiments on testbed of six (6) black-box optimization problems which are generated using a classical control problem and six (6) proven continuous RL agents demonstrate the efficiency of the proposed method in terms of faster convergence and scalability than the canonical ES. Furthermore, the proposed Adaptive Ensemble ES (AEES) shows an average of 5 - 10000x and 10 100x better sample complexity in low and high dimension problems, respectively than their associated base DRL agents. | Ajani, Oladayo S.; Mallipeddi, Rammohan | Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu, South Korea | AJANI, Oladayo/HIR-9607-2022; Mallipeddi, Rammohan/AAL-5306-2020 | 57465126000; 25639919900 | mallipeddi.ram@gmail.com; | KNOWLEDGE-BASED SYSTEMS | KNOWL-BASED SYST | 0950-7051 | 1872-7409 | 245 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE | 2022 | 8.8 | 12.8 | 1.56 | 2025-06-25 | 18 | 23 | Evolution strategy; Reinforcement Learning; Ensemble; Mutation strategy; Black-box optimization | INITIALIZATION; ADAPTATION | Black-box optimization; Ensemble; Evolution strategy; Mutation strategy; Reinforcement Learning | Complex networks; Evolutionary algorithms; Reinforcement learning; Adaptation process; Adaptive evolution; Black-box optimization; Ensemble; Evolution process; Evolution strategies; Mutation strategy; Neuro evolutions; Optimization problems; Reinforcement learnings; Optimization | English | 2022 | 2022-06-07 | 10.1016/j.knosys.2022.108624 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | A Plausible Mechanism of Uracil Photohydration Involves an Unusual Intermediate | It is well-known that photolysis of pyrimidine nucleobases, such as uracil, in an aqueous environment results in the formation of hydrate as one of the main products. Although several hypotheses regarding photohydration have been proposed in the past, e.g., the zwitterionic and "hot" ground-state mechanisms, its detailed mechanism remains elusive. Here, theoretical nonadiabatic simulations of the uracil photodynamics reveal the formation of a highly energetic but kinetically stable intermediate that features a half-chair puckered pyrimidine ring and a strongly twisted intracyclic double bond. The existence and the kinetic stability of the intermediate are confirmed by a variety of computational chemistry methods. According to the simulations, the unusual intermediate is mainly formed almost immediately (∼50-200 fs) upon photoabsorption and survives long enough to engage in a hydration reaction with a neighboring water. A plausible mechanism of uracil photohydration is proposed on the basis of the modeling of nucleophilic insertion of water into the twisted double bond of the intermediate. © 2022 American Chemical Society. All rights reserved. | Park, Woojin; Filatov, Michael; Sadiq, Saima; Gerasimov, Igor; Lee, Seunghoon; Joo, Taiha; Choi, Cheol Ho | Department of Chemistry, Kyungpook National University, Daegu, 41566, South Korea; Department of Chemistry, Kyungpook National University, Daegu, 41566, South Korea; Department of Chemistry, Kyungpook National University, Daegu, 41566, South Korea; Department of Chemistry, Kyungpook National University, Daegu, 41566, South Korea; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, 91125, CA, United States; Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea; Department of Chemistry, Kyungpook National University, Daegu, 41566, South Korea | 57223952329; 7005134246; 59029170800; 57202258853; 57194591254; 7004035449; 7402958948 | mike.filatov@gmail.com;cchoi@knu.ac.kr;thjoo@postech.ac.kr; | Journal of Physical Chemistry Letters | J PHYS CHEM LETT | 1948-7185 | N/A | 13 | 30 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2022 | 5.7 | 12.9 | 2.04 | 2025-06-25 | 24 | Kinetics; Photolysis; Pyrimidines; Uracil; Water; Aromatic compounds; Chemical bonds; Computational chemistry; Ground state; Hydration; Reaction intermediates; pyrimidine derivative; uracil; water; Aqueous environment; Double bonds; Hydration reaction; Kinetic stability; Non-adiabatic; Nucleobases; Photoabsorptions; Plausible mechanisms; Pyrimidine ring; Zwitterionics; chemistry; kinetics; photolysis; Photolysis | English | Final | 2022 | 10.1021/acs.jpclett.2c01694 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Circular RNA circSmoc1-2 regulates vascular calcification by acting as a miR-874-3p sponge in vascular smooth muscle cells | Vascular calcification (VC), or calcium deposition inside the blood vessels, is common in patients with atherosclerosis, cardiovascular disease, and chronic kidney disease. Although several treatments are available to reduce calcification, the incidence of VC continues to rise. Recently, there have been several reports describing the regulation of circular RNAs (circRNAs) in various diseases. However, the role of circRNAs in VC has not yet been fully explored. Here, we investigated the function of circSmoc1-2, one of the circRNAs generated from the Smoc1 gene, which is downregulated in response to VC. CircSmoc1-2 is localized primarily to the cytoplasm and is resistant to exonuclease digestion. Inhibition of circSmoc1-2 worsens VC, while overexpression of circSmoc1-2 reduces VC, suggesting that circSmoc1-2 can prevent calcification. We went on to investigate the mechanism of circSmoc1-2 as a microRNA sponge and noted that miR-874-3p, the predicted target of circSmoc1-2, promotes VC, while overexpression of circSmoc1-2 reduces VC by suppressing miR-874-3p. Additionally, we identified the potential mRNA target of miR-874-3p as Adam19. In conclusion, we revealed that the circSmoc1-2/miR-874-3p/Adam19 axis regulates VC, suggesting that circSmoc1-2 may be a novel therapeutic target in the treatment of VC. | Ryu, Juhee; Choe, Nakwon; Kwon, Duk-Hwa; Shin, Sera; Lim, Yeong-Hwan; Yoon, Gwangho; Kim, Ji Hye; Kim, Hyung Seok; Lee, In-Kyu; Ahn, Youngkeun; Park, Woo Jin; Kook, Hyun; Kim, Young-Kook | Chonnam Natl Univ, Res Inst Med Sci, Jeollanam Do, South Korea; Chonnam Natl Univ, Med Sch, BK21 FOUR Ctr Glocal Future Biomed Scientists, Jeollanam Do, South Korea; Chonnam Natl Univ, Basic Res Lab Vasc Remodeling, Med Sch, Jeollanam Do, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Chonnam Natl Univ, Dept Pharmacol, Med Sch, Jeollanam Do, South Korea; Chonnam Natl Univ, Dept Biochem, Med Sch, Jeollanam Do, South Korea; Chonnam Natl Univ, Hwasun Hosp, Biomed Res Inst, Jeollanam Do, South Korea; Chonnam Natl Univ, Dept Forens Med, Med Sch, Gwangju, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Chonnam Natl Univ Hosp, Cardiovasc Ctr, Dept Cardiol, Gwangju, South Korea; Gwangju Inst Sci & Technol GIST, Coll Life Sci, Gwangju, South Korea | ; Lee, In-Kyu/AAR-6374-2021; Kim, Young-Kook/AAE-8306-2020; Kook, Hyun/AAR-5405-2021 | 57208255566; 15847530800; 54392133700; 14422691900; 57192006927; 57208865908; 59643141000; 57218341796; 36071537600; 56937721300; 14058468000; 7006255524; 57208862490 | kookhyun@jnu.ac.kr;ykk@jnu.ac.kr; | MOLECULAR THERAPY NUCLEIC ACIDS | MOL THER-NUCL ACIDS | 2162-2531 | 27 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2022 | 8.8 | 12.9 | 1.87 | 2025-06-25 | 19 | 19 | PREVALENCE; MECHANISMS; TARGETS; DISEASE; CANCER | Adam19; circSmoc1-2; Circular RNA; miRNA-874-3p; vascular calcification; vascular smooth muscle cells | ADAM protein; circular ribonucleic acid; messenger RNA; microRNA; microrna 874; unclassified drug; animal cell; animal experiment; Article; blood vessel calcification; controlled study; down regulation; enzyme repression; gene overexpression; male; nonhuman; protein expression; rat; real time polymerase chain reaction; vascular smooth muscle cell | English | 2022 | 2022-03-08 | 10.1016/j.omtn.2021.12.031 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Conditional positive definiteness in operator theory | In this paper we extensively investigate the class of conditionally positive definite operators, namely operators generating conditionally positive definite sequences. This class itself contains subnormal operators, 2-and 3-isometries, complete hypercontractions of order 2 and much more beyond them. Quite a large part of the paper is devoted to the study of conditionally positive definite sequences of exponential growth with emphasis put on finding criteria for their positive definiteness, where both notions are understood in the semigroup sense. As a consequence, we obtain semispectral and dilation type representations for conditionally positive definite operators. We also show that the class of conditionally positive definite operators is closed under the operation of taking powers. On the basis of Agler's hereditary functional calculus, we build an L-infinity(M)-functional calculus for operators of this class, where M is an associated semispectral measure. We provide a variety of applications of this calculus to inequalities involving polynomials and analytic functions. In addition, we derive new necessary and sufficient conditions for a conditionally positive definite operator to be a subnormal contraction (including a telescopic condition). | Jablonski, Zenon Jan; Jung, Il Bong; Stochel, Jan | Uniwersytet Jagiellonski, Inst Matemat, Lojasiewicza 6, PL-30348 Krakow, Poland; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea | 6602624635; 7102964485; 6602273956 | Zenon.Jablonski@im.uj.edu.pl;ibjung@knu.ac.kr;Jan.Stochel@im.uj.edu.pl; | DISSERTATIONES MATHEMATICAE | DISS MATH | 0012-3862 | 1730-6310 | 578 | SCIE | MATHEMATICS | 2022 | 1.8 | 12.9 | 1.73 | 2025-06-25 | 4 | 7 | conditional positive definiteness; positive definiteness; subnormality; functional calculus | M-ISOMETRIC TRANSFORMATIONS; COMPLETE HYPEREXPANSIVITY; SUBNORMAL-OPERATORS; NORMAL EXTENSIONS; HILBERT | conditional positive definiteness; functional calculus; positive definiteness; subnormality | English | 2022 | 2022 | 10.4064/dm846-1-2022 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Determination of overall heat transfer coefficient for greenhouse energy-saving screen using Trnsys and hotbox | The high energy consumption in the greenhouse during the winter season necessitates the development of various thermal screens for energy-saving purposes. However, there is limited data on the precise properties of thermal screens, while little research has investigated a methodological approach for measuring the screen's energy-saving capacity for greenhouse energy efficiency. This research aims to determine the thermophysical, radiative, and aerodynamic properties of selected commercial greenhouse thermal screens. The transient system simulation (TRNSYS) model was used to simulate the heat flux and derive the thermal retention qualities of the thermal screens through their measured properties. The model was validated by comparing the simulated and experimental heat transfer coefficients, expressed as the overall heat transfer coefficient (U-value), thereby determining the thermal retention of the screens. In addition, the simulated U-value was compared to the experimental U-value in material permeability to investigate the influence of screen porosity on heat loss. The statistical analysis t-test was conducted to compare the U-values obtained from the simulation and the experimental hotbox. The simulated U values (for computed permeability) indicated that samples M1 and M3 exhibited the lowest U-value of 4.4 W m(-2) K-1, while white polyester, Luxous, PH-super, PH-66, M2, Clima45 (0), and New-Lux showed higher U-values of 82%, 105%, 161%, 123%, 41%, 102%, and 118%, respectively. Because of their low material porosity, M1, M2, and M3 samples showed better greenhouse thermal retention over others. Conclusively, the permeability features of the greenhouse energy screen materials have a substantial impact on their U-values. (C) 2022 IAgrE. Published by Elsevier Ltd. All rights reserved. | Rabiu, Anis; Na, Wook-Ho; Akpenpuun, Timothy Denen; Rasheed, Adnan; Adesanya, Misbaudeen Aderemi; Ogunlowo, Qazeem Opeyemi; Kim, Hyeon Tae; Lee, Hyun-Woo | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Agr Civil Engn, Daegu 702701, South Korea; Kyungpook Natl Univ, Smart Agr Innovat Ctr, Daegu 41566, South Korea; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin, Nigeria; Gyeongsang Natl Univ, Dept Bioind Machinery Engn, Jinju 52828, South Korea | Akpenpuun, Timothy/AAE-1168-2020; RABIU, Anis/JXO-1947-2024; Adesanya, Misbaudeen/AAA-4664-2022; Rasheed, Adnan/ABE-6624-2021; OGUNLOWO, QAZEEM/ABB-5386-2021 | 57264527100; 57211208368; 57194448083; 56080100700; 57264527200; 57265471800; 8662923200; 57209160180 | rabiuanis@gmail.com;Wooks121@hanmail.net;akpenpuun.td@unilorin.edu.ng;adnan.upm.spain@gmail.com;misbauadesanya@gmail.com;cosmosopy@yahoo.com;bioani@gnu.ac.kr;whlee@knu.ac.kr; | BIOSYSTEMS ENGINEERING | BIOSYST ENG | 1537-5110 | 1537-5129 | 217 | SCIE | AGRICULTURAL ENGINEERING;AGRICULTURE, MULTIDISCIPLINARY | 2022 | 5.1 | 12.9 | 2.17 | 2025-06-25 | 22 | 25 | Thermal screen; Permeability; Airflow; TRNSYS; Hotbox | INSECT-PROOF SCREENS; THERMAL-PROPERTIES; AIR-FLOW | Airflow; Hotbox; Permeability; Thermal screen; TRNSYS | Energy efficiency; Energy utilization; Greenhouses; Heat flux; Porosity; Airflow; Greenhouse energy; Hotbox; Permeability; System simulations; Thermal retention; Thermal screen; Transient system simulation; Transient systems; U values; Heat transfer coefficients | English | 2022 | 2022-05 | 10.1016/j.biosystemseng.2022.03.002 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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