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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Task Offloading in Terrestrial-Support-Free Multi-Layer Multi-Access Edge Computing | The article investigates aerial computing terrestrial-support-free multi-layer multi-access edge computing (AC-TMMEC) systems within the context of massive machine-type communications (mMTC) beyond 5G (B5G). With its four layers, namely space platform (S), high-altitude platform (HAP), low-altitude platform (LAP), and ground mobile access point platform (G), task offloading of ground users takes place in a sparsely distributed and dynamic environment mainly due to the high mobility of the AC-TMMEC entities. The article begins by reviewing the state-of-the-art, then identifies data routing and trajectory planning as new challenges in the design of AC-TMMEC offloading schemes. A simple yet effective task offloading scheme under AC-TMMEC, called iterative maximum flow algorithm (IMFA), is introduced, aiming to jointly solve the problems of source-destination pairing and data routing in a single shot via iterative maximum flow search. Extensive case studies are conducted to gain insights on the offloading latency performance of the proposed IMFA and compare it with a couple of counterparts with respect to two key parameters, namely the number of task requests and data size of each request. | Peng, Limei; Ho, Pin-Han; Zhao, Ke | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea; UESTC, Shenzhen Inst Adv Study, Chengdu, Peoples R China; Univ Waterloo, Dept Elect & Comp Engn, Waterloo, ON, Canada | zhao, ke/MGB-2778-2025 | 7201574271; 7402211578; 57439189700 | p4ho@uwaterloo.ca; | IEEE COMMUNICATIONS MAGAZINE | IEEE COMMUN MAG | 0163-6804 | 1558-1896 | 62 | 7 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2024 | 8.2 | 7.8 | 1.03 | 2025-05-07 | 0 | 4 | Surveys; Space vehicles; Multi-access edge computing; Trajectory planning; Routing; Search problems; Iterative methods | RESOURCE-ALLOCATION | 5G mobile communication systems; Antennas; Iterative methods; Space platforms; Computing system; Data routing; Edge computing; Low altitudes; Machinetype communication (MTC); Maximum-flow algorithm; Mobile access; Multi-layers; Multiaccess; Task offloading; Edge computing | English | 2024 | 2024-07 | 10.1109/mcom.001.2300020 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Ultra-stable gold nanoparticles based on N-heterocyclic carbene interfacial compound | Interfacial chemicals for metal surface functionalization were developed for applications of high water dispersibility and environmental stability. Metal nanomaterials, i.e., gold nanoparticles (AuNPs), were synthesized by introducing various interfacial chemicals, to improve the hydrophilicity of biosensors, such as those used in fluorescence resonance energy transfer (FRET) and lateral flow assay (LFA), respectively. Previously, thiolated AuNPs (SH-AuNPs) exhibited colloidal instability by forming irreversible aggregates in extreme environmental conditions; this phenomenon led to limitations such as poor sensitivity and reproducibility, in terms of biosensor application fields. Therefore, the development of novel interfacial chemicals remained a challenge for AuNP-based biosensor applications. Here, we first synthesized and demonstrated an ultra-stable AuNP functionalization by introducing N-heterocyclic carbene (NHC) compounds with a polyethylene glycol chain and azide terminal groups (NHC-AuNPs). The high binding energy of NHC-AuNPs compared with SH-AuNPs was demonstrated by density functional theory simulation, with NHC-AuNPs showing an unprecedented stability in extreme environmental conditions with varying ranges of pH, salts, and temperature; in particular, ultra-stability was observed in condition by freezing/thawing over 120 times. NHC-AuNPs were applied FRET and LFA biosensors and showed excellent sensing performances. Based on the results, NHC-AuNPs can be introduced for performance improvement in the development of diagnostic platforms to utilize in extreme environmental conditions. | Kim, Kyung Ho; Kim, Yejin; Seo, Sung Eun; Park, Chul Soon; Kim, Jinyoung; Kim, Yu Kyung; Kim, Hyoung-il; Park, Yoo Min; Kwon, Oh Seok | Sungkyunkwan Univ, SKKU Adv Inst Nanotechnol SAINT, Suwon 16419, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Infect Dis Res Ctr, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu 41944, South Korea; Bio Campus Korea Polytech, Dept Bionanomat, Nonsan 32943, South Korea; Yonsei Univ, Dept Civil & Environm Engn, Seoul 03722, South Korea; Ctr NanoBio Dev, Natl NanoFab Ctr, 291 Daehak Ro, Daejeon 34141, South Korea; Sungkyunkwan Univ, Dept Nano Sci & Technol, Suwon 16419, South Korea; Sungkyunkwan Univ SKKU, Dept Nano Engn, Suwon 16419, South Korea | ; Kim, Young-Il/ISS-7678-2023; Kim, Hyoung-il/D-1053-2014 | 57226848520; 57390938300; 57208651527; 57188864329; 59326345000; 9237571900; 57211720610; 55494468700; 7402195808 | hi.kim@yonsei.ac.kr;ympark@nnfc.re.kr;oskwon79@skku.edu; | APPLIED PHYSICS REVIEWS | APPL PHYS REV | 1931-9401 | 11 | 3 | SCIE | PHYSICS, APPLIED | 2024 | 11.6 | 7.8 | 0.35 | 2025-05-07 | 1 | 1 | SELF-ASSEMBLED MONOLAYERS; COLORIMETRIC DETECTION; CARE DIAGNOSTICS; SURFACES; AU(111); SIZE; FLUORESCENCE; ADSORPTION; DESORPTION; MOLECULES | Chlorine compounds; Doping (additives); Forster resonance energy transfer; Gold compounds; High energy forming; Melt spinning; Metal nanoparticles; Patternmaking; Biosensors applications; Environmental conditions; Fluorescence resonance energy transfer; Gold nanoparticle; Gold Nanoparticles; Interfacial chemicals; Interfacial compounds; Lateral-flow assays; N-heterocyclic carbenes; Synthesised; Gold nanoparticles | English | 2024 | 2024-09 | 10.1063/5.0210703 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Upadacitinib for Induction of Remission in Pediatric Ulcerative Colitis: An International Multicenter Study | Background and Aims: Data on upadacitinib therapy in children with ulcerative colitis (UC) or unclassified inflammatory bowel disease (IBD-U) are scarce. We aimed to evaluate the effectiveness and safety of upadacitinib as an induction therapy in pediatric UC or IBD-U. Methods: In this multicenter retrospective study, children treated with upadacitinib for induction of remission of active UC or IBD-U from 30 centers worldwide were enrolled. Demographic, clinical, and laboratory data, as well as adverse events (AEs), were recorded at Week 8 post-induction. Results: One hundred children were included (90 UC and 10 IBD-U, median age 15.6 [interquartile range 13.3–17.1] years). Ninety-eight were previously treated with biologic therapies, and 76 were treated with ≥2 biologics. At the end of the 8-week induction period, clinical response, clinical remission, and corticosteroid-free clinical remission (CFR) were observed in 84%, 62%, and 56% of the children, respectively. Normal C-reactive protein and fecal calprotectin (FC) <150 mcg/g were achieved in 75% and 50%, respectively. Combined CFR and FC remission was observed in 18/46 (39%) children with available data at 8 weeks. Adverse events were recorded in 37 children, including 1 serious AE of an appendiceal neuroendocrine tumor. The most frequent AEs were hyperlipidemia (n = 13), acne (n = 12), and infections (n = 10, 5 of whom with herpes viruses). Conclusions: Upadacitinib is an effective induction therapy for refractory pediatric UC and IBD-U. Efficacy should be weighed against the potential risks of AEs. © The Author(s) 2024. | Yerushalmy-Feler, Anat; Spencer, Elizabeth A.; Dolinger, Michael T.; Suskind, David L.; Mitrova, Katarina; Hradsky, Ondrej; Conrad, Máire A.; Kelsen, Judith R.; Uhlig, Holm H.; Tzivinikos, Christos; Ancona, Silvana; Wlazlo, Magdalena; Hackl, Lukas; Shouval, Dror S.; Bramuzzo, Matteo; Urlep, Darja; Olbjorn, Christine; D’Arcangelo, Giulia; Pujol-Muncunill, Gemma; Yogev, Dotan; Kang, Ben; Gasparetto, Marco; Rungø, Christine; Kolho, Kaija-Leena; Hojsak, Iva; Norsa, Lorenzo; Rinawi, Firas; Sansotta, Naire; Rimon, Ramit Magen; Granot, Maya; Scarallo, Luca; Trindade, Eunice; Rodríguez-Belvís, Marta Velasco; Turner, Dan; Cohen, Shlomi | Pediatric Gastroenterology Institute, “Dana-Dwek” Children’s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; Division of Pediatric Gastroenterology, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Division of Pediatric Gastroenterology, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States; University of Washington Medical School, Seattle, WA, United States, Seattle Children’s Hospital IBD Center, Seattle, WA, United States; Department of Paediatrics, Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic; Department of Paediatrics, Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic; Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA, United States; Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA, United States; Translational Gastroenterology Unit, University of Oxford, Oxford, United Kingdom, Biomedical Research Centre, University of Oxford, Oxford, United Kingdom, Department of Paediatrics, University of Oxford, Oxford, United Kingdom, Centre of Human Genetics, University of Oxford, Oxford, United Kingdom; Al Jalila Children’s Specialty Hospital, Dubai, United Arab Emirates; Department of Paediatric Gastroenterology and Nutrition, Royal Hospital for Children and Young People, Edinburgh, United Kingdom; Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland; Department of Pediatrics I, Medical University Innsbruck, Innsbruck, Austria; Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel, Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Institute for Maternal and Child Health-IRCCS “Burlo Garofolo, Trieste, Italy; Department of Gastroenterology, Hepatology and Nutrition, University Children’s Hospital Ljubljana, Ljubljana, Slovenia; Department of Paediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway; Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza-University of Rome, Rome, Italy; Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Hospital Sant Joan de Déu, Barcelona, Spain; The Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel; Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South Korea; Norfolk and Norwich University Hospital, Jenny Lind Children’s Hospital, University of East Anglia, Norwich Medical School, Norwich, United Kingdom; Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital—Amager and Hvidovre, Hvidovre, Denmark; Department of Paediatric Gastroenterology, Children’s Hospital, HUS and University of Helsinki, Helsinki, Finland; Children’s Hospital Zagreb, University of Zagreb Medical School, Zagreb, Croatia; Pediatric Department, Children’s Hospital Vittore Buzzi, University of Milan, Milan, Italy; Pediatric Gastroenterology Unit, Faculty of Medicine Technion, Haifa Emek Medical Centre, Afula, Israel; Pediatric Hepatology, Gastroenterology and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy; Rambam Health Care Campus, The Faculty of Medicine, Pediatric Gastroenterology & Nutrition Institute, Ruth Rappaport Children’s Hospital, Technion Israel Institute of Technology, Haifa, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, Pediatric Gastroenterology Unit, Edmond & Lily Safra Children’s Hospital, Sheba Medical Center, Ramat-Gan, Israel; Gastroenterology and Nutrition Unit, Meyer Children’s Hospital, Florence, Italy; Pediatric Gastroenterology and Nutrition Unit, Centro Hospitalar Universitário São João, Porto, Portugal; Department of Pediatric Gastroenterology and Nutrition, Hospital Infantil Universitario Niño Jesús, Madrid, Spain; Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Hospital Sant Joan de Déu, Barcelona, Spain; Pediatric Gastroenterology Institute, “Dana-Dwek” Children’s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel | 56016081800; 57202230518; 57206897899; 6603953112; 37017493900; 24280716400; 56964747200; 36174845600; 7004612677; 56230811200; 58067565000; 57223457372; 57202206421; 56024272300; 33067537800; 8964706700; 15760654500; 55607886700; 55959633100; 56888594200; 57194823199; 37861301600; 59553902800; 6701638121; 7801459343; 55207312500; 56262375400; 54883495800; 57974334500; 57204356090; 57204424323; 19838309800; 7201355120; 57198448551; 36808812900 | shlomico@tlvmc.gov.il; | Journal of Crohn's and Colitis | J CROHNS COLITIS | 1873-9946 | 1876-4479 | 20 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 8.7 | 7.8 | 1.67 | 2025-05-07 | 2 | children; Inflammatory bowel disease; JAK inhibitors | Adolescent; C-Reactive Protein; Child; Colitis, Ulcerative; Female; Heterocyclic Compounds, 3-Ring; Humans; Induction Chemotherapy; Leukocyte L1 Antigen Complex; Male; Pediatric ulcerative colitis; Remission Induction; Retrospective Studies; Treatment Outcome; adalimumab; azathioprine; biological product; C reactive protein; calgranulin; corticosteroid; cyclosporine; golimumab; infliximab; low density lipoprotein cholesterol; methotrexate; ozanimod; risankizumab; tacrolimus; tofacitinib; triacylglycerol; upadacitinib; ustekinumab; vedolizumab; C reactive protein; calgranulin; fused heterocyclic rings; upadacitinib; acne; adolescent; appendiceal neuroendocrine tumor; Article; atopic dermatitis; child; clinical outcome; cohort analysis; digestive system disease assessment; drug efficacy; drug safety; female; follow up; human; hyperlipidemia; infection; intention to treat analysis; major clinical study; male; multicenter study; Pediatric Ulcerative Colitis Activity Index; remission; retrospective study; selection bias; ulcerative colitis; clinical trial; drug therapy; induction chemotherapy; procedures; remission; treatment outcome; ulcerative colitis | English | Final | 2024 | 10.1093/ecco-jcc/jjae182 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Astraoleanosides E-P, oleanane-type triterpenoid saponins from the aerial parts of Astragalus membranaceus Bunge and their β-glucuronidase inhibitory activity | Historically, Astragalus membranaceus Bunge has been used as a beneficial medicinal plant, particularly in the Asian traditional medical systems, for the treatment of various human diseases such as stomach ulcers, diarrhea, and respiratory issues associated with phlegm. In this study, a phytochemical characterization of the aerial parts of A. membranaceus led to the isolation of 29 oleanane-type triterpenoid saponins, including 11 new compounds named astraoleanosides E-P (6-9, 13, 14, 18-22), as well as 18 known ones. The structures of these compounds were elucidated using nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry. Among them, astraoleanoside H (9) and cloversaponin III (15) demonstrated the most potent fl-glucuronidase inhibitory activities, with IC50 values of 21.20 +/- 0.75 and 9.05 +/- 0.47 mu M, respectively, compared to the positive control D-saccharic acid 1,4-lactone (IC50 = 20.62 +/- 1.61 mu M). Enzyme kinetics studies were then conducted to investigate the type of inhibition exhibited by these active compounds. In addition, the binding mechanism, key interactions, binding stability, and dynamic behavior of protein-ligand complexes were investigated through in silico approaches, such as molecular docking and molecular dynamics simulations. These findings highlight the promising potential of triterpenoid saponins from A. membranaceus as lead compounds for fl-glucuronidase inhibitors, offering new possibilities for the development of therapeutic agents targeting various diseases where fl-glucuronidase plays a crucial role. | Nguyen, Manh Khoa; Nguyen, Viet Phong; Yang, Seo Young; Min, Byung Sun; Kim, Jeong Ah | Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr, VOICE MRC, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug D, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Natl Inst Med Mat NIMM, Hanoi 100000, Vietnam; Kyungpook Natl Univ, Teachers Coll, Dept Biol Educ, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Phylogen & Evolut, Daegu 41566, South Korea; Daegu Catholic Univ, Coll Pharm, Drug Res & Dev Ctr, Gyeongbuk 38430, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Daegu Univ, Coll Pharm, Gyeongbuk 38430, South Korea | Nguyen, Viet Phong/AAQ-4207-2021 | 58907979100; 57205196739; 57215036954; 55663638200; 24722570900 | bsmin@cu.ac.kr;jkim6923@knu.ac.kr; | BIOORGANIC CHEMISTRY | BIOORG CHEM | 0045-2068 | 1090-2120 | 145 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, ORGANIC | 2024 | 4.7 | 7.9 | 1.28 | 2025-05-07 | 4 | 4 | Astragalus membranaceus; Astraoleanoside; Oleanane-type triterpenoid saponins; fl-Glucuronidase | GLYCOSIDES; CONSTITUENTS; PHARMACOLOGY; IRINOTECAN; CANCER; STEMS | Astragalus membranaceus; Astraoleanoside; Oleanane-type triterpenoid saponins; β-Glucuronidase | Astragalus propinquus; Humans; Molecular Docking Simulation; Molecular Structure; Oleanolic Acid; Plant Components, Aerial; Saponins; Triterpenes; astraisoolesaponin A1; astraisoolesaponin A2; astraisoolesaponin B; astraoleanoside A; astraoleanoside B; astraoleanoside C; astraoleanoside D; astraoleanoside E; astraoleanoside F; astraoleanoside G; astraoleanoside H; astraoleanoside I; astraoleanoside J; astraoleanoside K; astraoleanoside L; astraoleanoside M; astraoleanoside N; astraoleanoside O; astraoleanoside P; astroolesaponins A; astroolesaponins B; astroolesaponins E1; azukisaponin II; azukisaponin V; beta glucuronidase; cloversaponin III; glycosidase inhibitor; phytochemical; robinioside B; saccharolactone; saponin; triterpenoid; unclassified drug; oleanane; oleanolic acid; saponin; triterpene; aerial plant part; Article; Astragalus membranaceus; carbon nuclear magnetic resonance; controlled study; drug isolation; drug potency; drug protein binding; enzyme inhibition; enzyme inhibitor interaction; enzyme kinetics; heteronuclear multiple bond correlation; heteronuclear multiple quantum coherence; IC50; mass spectrometry; molecular docking; molecular dynamics; proton nuclear magnetic resonance; aerial plant part; Astragalus propinquus; chemical structure; chemistry; human | English | 2024 | 2024-04 | 10.1016/j.bioorg.2024.107230 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Dynamic response of RC frames retrofitted with friction-damped brace system through shaking table tests | This study presents the shaking table test results of two-dimensional reinforced concrete (RC) frames retrofitted with a simplified friction damped brace. An easy-to-manufacture and install friction damper with economical design, was proposed and tested under reversed cyclic loading and used to retrofit RC frames. The splice of a conventional steel brace was converted into a friction damper, which not only dissipated seismic energy but also helped avoid the buckling of the steel brace. The test scheme consisted of four RC frames, and the behaviors of the three retrofitted frames were compared with that of a non-retrofitted (bare) frame. The shaking table tests were conducted using an artificial seismic wave that reflected the short-period response characteristics of the Korean earthquake. The test results of the bare and retrofitted frames were analyzed by considering several important performance indicators, such as the cracking and fracture mechanism in the RC frames, base share, and story drift ratios. The results of the shaking table tests demonstrated that the proposed damped brace effectively reduced earthquake-induced drift demands and successfully shifted the fracture and damage concentration from the columns to the beams. | Shin, Hye-Min; Haroon, Muhammad; Shin, Kyung-Jae; Lee, Hee-Du | Korea Atom Energy Res Inst, Struct & Seism Safety Res Div, Deajeon 34057, South Korea; Kyungpook Natl Univ, Reg Ctr Land Infrastruct & Transport Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Architecture, Daegu 41566, South Korea | Haroon, Muhammad/KTI-4019-2024 | 57206950005; 57211005074; 14039501000; 53865180300 | lhdza@knu.ac.kr; | CASE STUDIES IN CONSTRUCTION MATERIALS | CASE STUD CONSTR MAT | 2214-5095 | 20 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 6.6 | 7.9 | 0.43 | 2025-05-07 | 2 | 2 | Seismic retrofitting; Energy dissipation; Friction dampers; Shaking table test | SEISMIC PERFORMANCE EVALUATION; CONNECTION; DESIGN; VALIDATION; PRECAST; FORCE | Energy dissipation; Friction dampers; Seismic retrofitting; Shaking table test | Earthquakes; Energy dissipation; Reinforced concrete; Retrofitting; Conventional steel; Economical design; Friction damper; Reinforced concrete frames; Reversed cyclic loading; Seismic energy; Seismic retrofitting; Shaking table tests; Steel braces; Two-dimensional; Friction | English | 2024 | 2024-07 | 10.1016/j.cscm.2023.e02725 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | HarmoSATE: Harmonized embedding-based self-attentive encoder to improve accuracy of privacy-preserving federated predictive analysis | Accurate privacy -preserving prediction using electronic health record (EHR) data distributed in multiple hospitals is essential to enable stakeholders related to healthcare services to obtain useful information without privacy leakage. In this paper, we propose harmonized embedding -based self -attentive encoder (HarmoSATE), which is a new method for privacy -preserving federated predictive analysis. We extract contextual embeddings of local institutions using Word2Vec, and then harmonize locally -trained embeddings using a neural network -based harmonization technique. The proposed method uses a deep representative encoder based on self -attention to learn complex and dynamic patterns inherent to harmonized embeddings of medical concepts. To evaluate our method, we implemented experiments using sequential medical codes collected from the Medical Information Mart for Intensive Care -III dataset in a distributed setting. It achieved a significant increase in average AUC, ranging from 3% to 8% depending on the experiments compared to baseline models, demonstrating superior prediction accuracy of a patient's diagnosis in the next admission. HarmoSATE can be a useful alternative to obtain accurate and practical results for various predictive tasks that use sensitive and distributed EHR data while preserving patients' privacy. | Lee, Taek-Ho; Kim, Suhyeon; Lee, Junghye; Jun, Chi-Hyuck | Seoul Natl Univ, Econ & Policy Program, Technol Management, 1 Gwanak Ro, Seoul 08826, South Korea; Seoul Natl Univ, Inst Engn Res, 1 Gwanak Ro, Seoul 08826, South Korea; Kyungpook Natl Univ, Grad Sch Data Sci, Daegu 41566, South Korea; Seoul Natl Univ, Grad Sch Engn Practice, 1 Gwanak Ro, Seoul 08826, South Korea; Pohang Univ Sci & Technol POSTECH, Dept Ind & Management Engn, 77 Cheongam Ro, Pohang 37673, South Korea | Jun, Chi-Hyuck/AAE-1695-2019; Lee, Junghye/KUF-0668-2024 | 57194686484; 57216511251; 56055191300; 16245299200 | taekholee@snu.ac.kr;suhyeonkim@knu.ac.kr;chjun@postech.ac.kr;junghye@snu.ac.kr; | INFORMATION SCIENCES | INFORM SCIENCES | 0020-0255 | 1872-6291 | 662 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS | 2024 | 6.8 | 7.9 | 0.33 | 2025-05-07 | 1 | 3 | Privacy-preserving; Harmonization; Contextual embedding; Self-attention; Deep learning | DE-IDENTIFICATION; SECURE; REGRESSION; EFFICIENT | Contextual embedding; Deep learning; Harmonization; Privacy-preserving; Self-attention | Deep learning; Diagnosis; Predictive analytics; Privacy-preserving techniques; Signal encoding; Contextual embedding; Data distributed; Deep learning; Electronic health; Embeddings; Harmonisation; Health records; Healthcare services; Privacy preserving; Self-attention; Embeddings | English | 2024 | 2024-03 | 10.1016/j.ins.2024.120265 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Parametric image-based concrete defect assessment method | Structural health monitoring aims to ensure the integrity of infrastructure. Assessing structural integrity through image classification techniques based on human perception is often challenging. Incorporating a morphological image-based crack detection algorithm can mitigate these limitations. This study proposes a parametric approach for concrete crack analysis using digital image processing techniques. The objective is to detect damage to the concrete surface of infrastructures, potentially exacerbating structural deterioration. The research justifies the utilization of digital parametric image processing techniques, including a weighted median filter, grayscale, Otsu filter, and other methods. These techniques were applied to evaluate different concrete images for crack detection. The findings were validated through Image Quality Assessment (IQA), determining the condition of the studied images and statistical properties using metrics such as Mean Squared Error (MSE), Peak Signal-to-Noise Ratio (PSNR), Structural Similarity Index (SSIM), Blind/Referenceless Image Spatial Quality Evaluator (BRISQUE), Natural Image Quality Evaluator (NIQE), and Perceptual Image Quality Evaluator (PIQE). Additionally, uncontrollable factors such as variations in lighting effects under different conditions, testing setups, and different textures of the concrete were considered in this study. The comprehensive experimental results demonstrated that the Otsu filter outperforms other filtering techniques. Overall, the study achieved remarkable accuracy, approximately 95%, in detecting cracks on building infrastructure. The proposed method holds potential for integration with advanced techniques in practical applications for the maintenance and safety of infrastructure. This research not only contributes to technological advancements in concrete defect assessment but also carries significant implications for the future of automated and reliable structural health monitoring. | Lee, Dong-Eun; Choi, Young; Hong, Geuntae; Maruthi, M.; Yi, Chang-Yong; Park, Young- Jun | Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, 80 Daehak Ro, Daegu 41566, South Korea; Earth Turbine, 36,Dongdeok Ro 40 Gil, Daegu 41905, South Korea; Kyungpook Natl Univ, Dept Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea | ; Hong, Geuntae/AAM-8586-2020 | 56605563300; 58937691800; 57193714827; 58892238800; 36614886300; 57191258386 | cyyi@knu.ac.kr;py0307@knu.ac.kr; | CASE STUDIES IN CONSTRUCTION MATERIALS | CASE STUD CONSTR MAT | 2214-5095 | 20 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 6.6 | 7.9 | 0.87 | 2025-05-07 | 0 | 2 | Concrete defects; Damage assessment; Image-based analysis; Parametric evaluation; Structural health assessment; Morphological technique | AUTOMATIC CRACK DETECTION; NDT/SDT METHODS; DAMAGE; RECOGNITION | Concrete defects; Damage assessment; Image-based analysis; Morphological technique; Parametric evaluation; Structural health assessment | Concretes; Damage detection; Deterioration; Image quality; Mean square error; Median filters; Parameter estimation; Signal to noise ratio; Structural health monitoring; Textures; Concrete defects; Damage assessments; Health assessments; Image-based; Image-based analysis; Morphological technique; Parametric evaluation; Parametric image; Structural health; Structural health assessment; Crack detection | English | 2024 | 2024-07 | 10.1016/j.cscm.2024.e02962 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Real-time assessment of rebar intervals using a computer vision-based DVNet model for improved structural integrity | Structural durability is critical for building and civil engineering safety, wherein the arrangement and distribution of reinforcing bar (rebar) is crucial. Improperly aligned rebar impacts bearing capacity, whereas uniform spacing optimally distributes loads, reducing stress. We introduce a computer-vision based Deep Vision Net (DVNet) model for real-time evaluation of rebar placement. A customized dataset is prepared in an environmental setup and augmented to address overfitting issues. This research conducts a comparative analysis of the learning performance exhibited by the proposed DVNet model against several other pre-trained models, such as MaskRCNN and YOLOv5. The proposed DVNet model is built on a customized DeepCNN architecture, achieving a commendable precision of 88.6% and recall of 89.3%. Utilizing the DVNet model, the real-time assessments of rebar placements were performed at various spacing intervals. Experimental results demonstrate that the DVNet-based model excels at ensuring the structural arrangements of the rebar intervals. | Kim, Bubryur; Preethaa, K. R. Sri; Natarajan, Yuvaraj; Danushkumar, V.; An, Jinwoo; Lee, Dong-Eun | Kyungpook Natl Univ, Sch Space Engn Sci, 80 Daehak Ro, Daegu 41566, South Korea; Vellore Inst Technol, Sch Comp Sci & Engn, Vellore 632014, India; Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea; HP Inc, R&D, Bangalore, India; Univ Texas Rio Grande Valley, Coll Engn & Comp Sci, Dept Comp Sci, Edinburg, TX 78539 USA; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, 80 Daehak Ro, Daegu 41566, South Korea | raj, yuva/GWV-2080-2022 | 57198355299; 57214320928; 57204528689; 59321294100; 56319889200; 56605563300 | brkim@knu.ac.kr;sripreethaakr@gmail.com;yuvaraj.n@vit.ac.in;danushvenkadesh@gmail.com;jinwoo.an@utrgv.edu;dolee@knu.ac.kr; | CASE STUDIES IN CONSTRUCTION MATERIALS | CASE STUD CONSTR MAT | 2214-5095 | 21 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 6.6 | 7.9 | 0.43 | 2025-05-07 | 2 | 1 | Rebar; Structural health; Convolution neural network; Segmentation; Deep neural network | INSPECTION; CONCRETE; NETWORK | Convolution neural network; Deep neural network; Rebar; Segmentation; Structural health | Environmental remediation; Rebar; Structural engineering; Structural integrity; Convolution neural network; Engineering safety; Net model; Neural-networks; Real-time assessment; Reinforcing bar; Segmentation; Structural durability; Structural health; Vision based; Structural Mechanics | English | 2024 | 2024-12 | 10.1016/j.cscm.2024.e03707 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Robust corrective control against fundamental and non-fundamental mode attacks with application to an asynchronous digital system | This article presents a robust model matching corrective control scheme for input/state asynchronous sequential machines (ASMs) vulnerable to both fundamental and non -fundamental mode attacks. Specifically, when non -fundamental mode attacks occur, ASMs undergo unauthorized state transitions in their transient behaviors, reaching faulty states. The attack outcome is exacerbated if non -fundamental mode attacks occur during the procedure of model matching by the controller. We address the necessary and sufficient condition and design procedure for a stateburst -feedback corrective controller that eliminates the adverse effect of both fundamental and non -fundamental mode attacks, while matching the stable -state behavior of the closed -loop system to that of a reference model. To demonstrate the synthesis of the controller and applicability of the proposed scheme, a practical ASM termed the payload data manager and the corrective controller are implemented on field -programmable gate array (FPGA) circuits. Experimental results are provided on model matching and robust corrective control overcoming both fundamental and non -fundamental mode attacks. | Yang, Jung -Min; Kwak, Seong Woo | Kyungpook Natl Univ, Sch Elect Engn, 80 Daehakro, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Control & Instrumentat Engn, Pusan 48513, South Korea | 57208450551; 59816855300 | jmyang@ee.knu.ac.kr;ksw@pknu.ac.kr; | INFORMATION SCIENCES | INFORM SCIENCES | 0020-0255 | 1872-6291 | 661 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS | 2024 | 6.8 | 7.9 | 0 | 2025-05-07 | 0 | 0 | Asynchronous sequential machines (ASMs); Corrective control; Model matching; Non-fundamental mode attacks; Field-programmable gate array (FPGA) | DATA INJECTION ATTACKS; SEQUENTIAL-MACHINES; INPUT/OUTPUT CONTROL; STATE ESTIMATION; MITIGATION; SECURITY; DESIGN | Asynchronous sequential machines (ASMs); Corrective control; Field-programmable gate array (FPGA); Model matching; Non-fundamental mode attacks | Closed loop systems; Field programmable gate arrays (FPGA); Logic gates; Logic Synthesis; Sequential machines; Asynchronoi sequential machine; Asynchronous sequential machines; Corrective control; Digital system; Field programmables; Field-programmable gate array; Fundamental modes; Model matching; Non-fundamental mode attack; Programmable gate array; Controllers | English | 2024 | 2024-03 | 10.1016/j.ins.2024.120145 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Sucrosephenylpropanoid esters and isoflavonoids isolated from Belamcanda chinensis roots and their potential anti-osteoclastogenic activity | Repeated chromatography of the CH2Cl2 and EtOAc soluble fractions from the methanol extract of Belamcanda chinensis root yielded six new sucrosephenylpropanoid esters (1-6) and twenty-one known compounds (7-27). The structures of 1-6 were elucidated using diverse nuclear magnetic resonance (NMR) techniques and high-resolution mass spectrometry (HRMS) data analysis, together with chemical methods. All the twenty-seven isolated compounds were evaluated for their anti-osteoclastogenic activities. Preliminary screening results revealed that compounds 1 and 19 exhibited strong effects against RANKL-induced osteoclast formation in RAW264.7 cells. In addition, the treatment of mouse bone marrow macrophages (BMMs) with compounds 1 and 19 significantly decreased RANKL-induced TRAP-positive multinucleated osteoclast formation in a concentration-dependent manner without affecting cell viability. Further bioassay investigation showed that compounds 1 and 19 inhibited the expression of some osteoclast-specific marker genes and the transcription factor nuclear factor of activated T cells cytoplasmic 1 (NFATc1) in response to RANKL. To the best of our knowledge, this is the first investigation of anti-osteoclastogenic activity for compounds isolated from B. chinensis. | Ha, Manh Tuan; Gal, Minju; Kim, Jeong Ah; Lee, Jeong-Hyung; Min, Byung Sun | Daegu Catholic Univ, Coll Pharm, Drug Res & Dev Ctr, Gyeongbuk 38430, South Korea; Kangwon Natl Univ, Coll Nat Sci, Dept Biochem, Chunchon 24341, Gangwon, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea | Tuan, Ha/AAW-5444-2021 | 57189040434; 57224117184; 24722570900; 26662839900; 55663638200 | jhlee36@kangwon.ac.kr;bsmin@cu.ac.kr; | BIOORGANIC CHEMISTRY | BIOORG CHEM | 0045-2068 | 1090-2120 | 143 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, ORGANIC | 2024 | 4.7 | 7.9 | 1.28 | 2025-05-07 | 3 | 3 | Belamcanda chinensis; Iridaceae; Sucrosephenylpropanoid esters; Osteoclastogenesis; RANKL; NFATc1 | PHENOLIC CONSTITUENTS; IRIS; FLAVONES | Belamcanda chinensis; Iridaceae; NFATc1; Osteoclastogenesis; RANKL; Sucrosephenylpropanoid esters | Animals; Bone Resorption; Cell Differentiation; Mice; NFATC Transcription Factors; Osteoclasts; Osteogenesis; 16 o acetyliridobelamal A; 16 o acetylisoiridogermanal; 3,5,4' trihydroxy 7,5' dimethoxyflavanone; 3,5,5' trihydroxy 7,3',4' trimethoxyflavanone; 6'' o 4 hydroxybenzoyliridin; 6'' o vanilloyliridin; acid phosphatase tartrate resistant isoenzyme; aurantiin; belamchinoside A; belamchinoside C; belamchinoside D; belamchinoside E; belamchinoside F; bone density conservation agent; dichotomitin; flavonoid; genistein; hispidulin; iridin; iridobelamal A; irigenin; irilin D; irilone; irisflorentin; iristectorene B; iristectorigenin A; isoflavonoid; isoiridogermanal; kaempferol; kanzakiflavone 2; luteolin; noririsflorentin; nuclear factor of activated T cell cytoplasmic 1; osteoclast differentiation factor; plant extract; polyphenol; quercetin; rutoside; sucrose ester derivative; sucrosephenylpropanoid ester; tectorigenin; transcription factor NFAT; unclassified drug; transcription factor NFAT; acid hydrolysis; alkaline hydrolysis; animal cell; animal experiment; antiosteoporotic activity; Article; Belamcanda chinensis; bone marrow; bone marrow derived macrophage; cell viability; concentration response; controlled study; data analysis; drug isolation; drug screening; drug structure; heteronuclear multiple bond correlation; high performance liquid chromatography; in vitro study; Iridaceae; marker gene; mass spectrometry; mouse; nonhuman; nuclear magnetic resonance; osteoclast; osteoclastogenesis; plant root; RAW 264.7 cell line; real time polymerase chain reaction; animal; bone development; cell differentiation; genetics; metabolism; osteolysis; prevention and control | English | 2024 | 2024-02 | 10.1016/j.bioorg.2023.107066 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | AIMP1-Derived Peptide Secreted from Hair Follicle Stem Cells Promotes Hair Growth by Activating Dermal Papilla Cells | Hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs) are crucial in the biogenesis and maintenance of hair follicles (HFs). This study demonstrated that a fragment derived from aminoacyl-tRNA synthetase-interacting multifunctional protein1 (AIMP1) secreted from HFSCs activated DPCs and maintained HF homeostasis. A histological analysis revealed that AIMP1 levels in HF decreased with hair loss. Hair regrowth in AIMP1-induced mice was faster than in non-induced mice. Deletion mapping revealed 41 amino acids (TN41, aa 6-46) as the active region of AIMP1. The N-terminal peptide fragment of AIMP1 generated by MMP1 was secreted from Wnt-treated HFSCs to activate DPCs. TN41 activated Akt and ERK, increased beta-catenin, and enhanced DPC activation. TN41 promoted hair shaft elongation in cultured human HFs and improved the hair-inducing activity of cultured DPC spheroids. Our findings suggest that the AIMP1 fragment secreted from HFSCs stimulates active hair regrowth through activating DPCs. | Kim, YounHa; Kim, Sang Bum; Lee, Ho; Kim, Doyeun; Bak, Soon Sun; Yoon, Ina; Cho, Seongmin; Jeong, Seung Jae; Jeon, Yoon; Kim, Jina; Kim, Ji-hee; Oh, Soohwan; Battogtokh, Khas-Erdene; Park, Min Chul; Sung, Young Kwan; Kim, Sunghoon | Yonsei Univ, Gangnam Severance Hosp, Inst Artificial Intelligence & Biomed Res, Med Bioconvergence Res Ctr,Coll Pharm,Dept Integra, 85 Songdogwahak Ro, Incheon 21983, South Korea; Natl Canc Ctr, Grad Sch Canc Sci & Policy, Gyeonggi 10408, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Sahmyook Univ, Coll Pharm, Seoul, South Korea; CureBio Therapeut Co Ltd, 12fl,91,Changnyong Daero 256beon Gil, Suwon, Gyeonggi Do, South Korea; Korea Univ, Coll Pharm, 2511 Sejong Ro, Sejong 30019, South Korea; Inje Univ, Inje Inst Pharmaceut Sci & Res, Coll Pharm, Gimhae, South Korea; Yonsei Univ, Yonsei Inst Pharmaceut Sci, Coll Pharm, Incheon 21983, South Korea | 57188574288; 57196231559; 55183466500; 55842698700; 41561065700; 56448180300; 57194746624; 37001772800; 35310444600; 59399994700; 59345816700; 55748943400; 59399649100; 58112195400; 55663365300; 58237338700 | ysung@knu.ac.kr;sunghoonkim@yonsei.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | INT J BIOL SCI | 1449-2288 | 20 | 14 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2024 | 10 | 8.0 | 0 | 2025-05-07 | 0 | 0 | hair follicle stem cell; dermal papilla cell; AIMP1; hair growth | SKIN; P43; PROLIFERATION; AIMP1/P43; COMPLEX; PROTEIN; GUIDE | AIMP1; dermal papilla cell; hair follicle stem cell; hair growth | Animals; Cells, Cultured; Dermis; Hair; Hair Follicle; Humans; Mice; Mice, Inbred C57BL; Stem Cells; animal; C57BL mouse; cell culture; cytology; dermis; growth, development and aging; hair; hair follicle; human; metabolism; mouse; stem cell | English | 2024 | 2024 | 10.7150/ijbs.101127 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Hyperpolarized water via dissolution dynamic nuclear polarization: Applications in biomolecular NMR | Although traditional nuclear magnetic resonance (NMR) spectroscopy is essential for investigating the structures and dynamics of biomolecules, it is impeded by low sensitivity, particularly under physiological conditions. Hyperpolarization techniques, which considerably amplify NMR signal intensity, have emerged as novel solutions in this field. Among the various hyperpolarization techniques and applications, hyperpolarized water obtained using dissolution dynamic nuclear polarization has been extensively used for the study of biomolecules. This review details the findings of NMR studies involving hyperpolarized water and its potential for biomolecular studies, with applications spanning from revealing molecular interactions under challenging experimental conditions to facilitating real-time NMR applications during structural changes in biomolecules. Further studies are required to thoroughly understand polarization transfer from hyperpolarized water, propelling this field toward unprecedented possibilities and providing biological insights. | Lee, Youngbok; Kim, Jihyun | Hanyang Univ, Ctr Bionano Intelligence Educ & Res, Dept Appl Chem, Ansan, South Korea; Kyungpook Natl Univ, Dept Chem Educ, Daegu, South Korea; Hanyang Univ, Ctr Bionano Intelligence Educ & Res, Dept Appl Chem, Ansan 15588, South Korea; Kyungpook Natl Univ, Dept Chem Educ, Daegu 41566, South Korea | 57061063600; 56954528100 | yblee@hanyang.ac.kr;jkim23@knu.ac.kr; | APPLIED SPECTROSCOPY REVIEWS | APPL SPECTROSC REV | 0570-4928 | 1520-569X | 59 | 9 | SCIE | INSTRUMENTS & INSTRUMENTATION;SPECTROSCOPY | 2024 | 5.4 | 8.0 | 0 | 2025-04-16 | 0 | 0 | Nuclear magnetic resonance spectroscopy; hyperpolarization; dissolution dynamic nuclear polarization; biomolecular NMR | MAGNETIC-RESONANCE-SPECTROSCOPY; PROTEIN OSTEOPONTIN; METASTASIS; EXCHANGE; ENHANCEMENT; INJECTION; KINETICS; SPECTRA | biomolecular NMR; dissolution dynamic nuclear polarization; hyperpolarization; Nuclear magnetic resonance spectroscopy | Biomolecules; Dissolution; Nuclear magnetic resonance; Spin polarization; Bio-molecular; Biomolecular nuclear magnetic resonance; Dissolution dynamic nuclear polarization; Dissolution dynamics; Dynamic nuclear polarization; Hyperpolarization; Hyperpolarized waters; Low sensitivity; Physiological condition; Structure and dynamics; Nuclear magnetic resonance spectroscopy | English | 2024 | 2024-10-20 | 10.1080/05704928.2024.2324821 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Prevalence and population genetic analyses of parasites in invasive Vespa velutina and native Hymenoptera | Invasive species pose a threat to the ecological balance of the ecosystems they invade by altering local hostpathogen dynamics. To investigate these relationships and their potential consequences, we examined the prevalence and genetic diversity patterns of Trypanosomatidae, Lipotrophidae, and Nosematidae in a collection of sympatric isolates of the invasive hornet Vespa velutina and local Hymenoptera from two recently colonized areas: Europe and South Korea. Data were gathered through PCR amplification and massive parallel sequencing, and analyses were conducted using population genetics tools. Parasite prevalences showed substantial variation depending on (i) the parasite family (Trypanosomatidae and Nosematidae were the most and less prevalent, respectively), (ii) location (e.g. Galicia displayed the highest pooled values), (iii) the season (highest in spring for Trypanosomatidae and Lipotrophidae), and (iv) the host. V. velutina exhibited significantly lower parasite occurrence than native Hymenoptera across all parasite families (consistent with the enemy release hypothesis), although this difference was less pronounced during the periods of heightened predatory activity, suggestive of trophic transmission. Parasite species displayed significant genetic differentiation between European and South Korean isolates, yet no differentiation was observed across hosts, suggesting that all Hymenoptera are exposed to a common local pathogen population. There was no indication that V. velutina acted as a carrier of foreign parasites to the invaded territories. | Bartolome, Carolina; Dasilva-Martins, Damian; Valinas, Rosa; Gabin-Garcia, Luis B.; Nave, Anabela; Garcia-Perez, Ana L.; Monceau, Karine; Thiery, Denis; Christie, Alastair; Choi, Moon Bo; Sobrino, Beatriz; Amigo, Jorge; Maside, Xulio | Univ Santiago De Compostela, Grp Med Xen, CIMUS, Santiago De Compostela 15782, Galicia, Spain; Inst Invest Sanit Santiago IDIS, Santiago De Compostela 15706, Galicia, Spain; Univ Tras Os Montes & Alto Douro, Ctr Invest & Tecnol Agroambientais & Biol, CITAB, UTAD, P-5000801 Vila Real, Portugal; Inst Nacl Invest Agr & Vet IP INIAV, Unidade Estrateg Sistemas Agr & Florestais & Sanid, Av Republ, P-2780157 Oeiras, Portugal; Basque Res & Technol Alliance BRTA, NEIKER Basque Inst Agr Res & Dev, Dept Anim Hlth, Derio 48160, Bizkaia, Spain; La Rochelle Univ, Ctr Etud Biol Chize, UMR 7372, F-79360 Villiers En Bois, France; CNRS, F-79360 Villiers En Bois, France; INRAE, UMR1065, SAVE, F-33140 Villenave Dornon, France; Govt Jersey, Nat Environm, Route Trinite, St Helier JE3 5JP, Jersey, England; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Serv Galego Saude SERGAS, Fdn Publ Galega Med Xen, Santiago De Compostela 15706, Galicia, Spain | ; Monceau, Karine/P-4755-2016; Garcia Perez, Ana/KOC-2348-2024; Maside, Xulio/AAU-8864-2020; Lechuga, Jorge/A-4892-2010; Amigo, Jorge/A-4892-2010; Nave, Anabela/IWU-4852-2023 | 6602671497; 57876794700; 59340925300; 57192711075; 56764065300; 7103070007; 25930092200; 7003426843; 59340504300; 51863232400; 8784650300; 24464783100; 6603011840 | carolina.bartolome@usc.gal;damian.dasilva@usc.gal;anabela.nave@iniav.pt;Karine.Monceau@univ-lr.fr;A.Christie2@gov.je;kosinchoi@hanmail.net;beatriz.sobrino@usc.es;jorge.amigo@usc.es;xulio.maside@usc.gal; | JOURNAL OF INVERTEBRATE PATHOLOGY | J INVERTEBR PATHOL | 0022-2011 | 1096-0805 | 207 | SCIE | ZOOLOGY | 2024 | 2.4 | 8.0 | 0 | 2025-05-07 | 1 | 1 | Vespa velutina; Invasive species; Native Hymenoptera; Nosematidae; Trypanosomatidae; Lipotrophidae | NOSEMA-CERANAE MICROSPORIDIA; DIVERSITY; BEES | Invasive species; Lipotrophidae; Native Hymenoptera; Nosematidae; Trypanosomatidae; Vespa velutina | Animals; Europe; Genetic Variation; Host-Parasite Interactions; Hymenoptera; Introduced Species; Prevalence; Republic of Korea; Wasps; animal; Europe; genetic variation; genetics; host parasite interaction; Hymenoptera; introduced species; prevalence; South Korea; wasp | English | 2024 | 2024-11 | 10.1016/j.jip.2024.108203 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Transcriptomic profiling and the first spatial expression analysis of candidate genes in the salivary gland of the East Asian medicinal leech, Hirudo nipponia | Hirudo nipponia, a blood-sucking leech native to East Asia, possesses a rich repertoire of active ingredients in its saliva, showcasing significant medical potential due to its anticoagulant, anti-inflammatory, and antibacterial effects against human diseases. Despite previous studies on the transcriptomic and proteomic characteristics of leech saliva, which have identified medicinal compounds, our knowledge of tissue-specific transcriptomes and their spatial expression patterns remains incomplete. In this study, we conducted an extensive transcriptomic profiling of the salivary gland tissue in H. nipponia based on de novo assemblies of tissue-specific transcriptomes from the salivary gland, teeth, and general head region. Through gene ontology (GO) analysis and hierarchical clustering, we discovered a novel set of anti-coagulant factors-i.e., Hni-Antistasin, Hni-Ghilanten, Hni-Bdellin, Hni-Hirudin-as well as a previously unrecognized immune-related gene, Hni-GLIPR1 and uncharacterized salivary gland specific transcripts. By employing in situ hybridization, we provided the first visualization of gene expression sites within the salivary gland of H. nipponia. Our findings expand on our understanding of transcripts specifically expressed in the salivary gland of blood-sucking leeches, offering valuable resources for the exploration of previously unidentified substances with medicinal applications. | Kim, Jung-Hyeuk; Lee, Chan-Jun; Yu, Yun-Sang; Aryal, Yam Prasad; Kim, Sangil; Suh, Jo- Young; Kim, Jae-Young; Min, Sun Hong; Cha, In-Tae; Lee, Hae-Youn; Shin, Song Yub; Cho, Sung-Jin | Chungbuk Natl Univ, Coll Nat Sci, Dept Biol Sci & Biotechnol, Cheongju 28644, Chungbuk, South Korea; Natl Inst Wildlife Dis Control & Prevent, Wildlife Dis Response Team, Incheon 22689, South Korea; Harvard Univ, Museum Comparat Zool, Cambridge, MA 02138 USA; Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA; Chosun Univ, Sch Med, Dept Cellular & Mol Med, Gwangju 61452, South Korea; IHBR Kyungpook Natl Univ, Sch Dent, Dept Periodontol, Daegu 41940, South Korea; Konkuk Univ, Dept Cosmet Engn, Seoul 05029, South Korea; Natl Inst Biol Resources NIBR, Species Divers Res Div, Incheon 22689, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Biochem, IHBR, Daegu 41940, South Korea | 57224009473; 57852410500; 57192191441; 57202611163; 57201465345; 7201514992; 56812734700; 58876068000; 23392245000; 57216173878; 35749114100; 58879172200 | hylee71@chungbuk.ac.kr;syshin@chosun.ac.kr;sjchobio@chungbuk.ac.kr; | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | DEV COMP IMMUNOL | 0145-305X | 1879-0089 | 154 | SCIE | FISHERIES;IMMUNOLOGY;VETERINARY SCIENCES;ZOOLOGY | 2024 | 2.4 | 8.0 | 0.62 | 2025-05-07 | 2 | 2 | Medicinal leech; Salivary gland; De novo transcriptome assembly; Immune related protein; Spatial expression analysis | SEQUENCE; CELLS | De novo transcriptome assembly; Immune related protein; Medicinal leech; Salivary gland; Spatial expression analysis | Animals; Gene Expression Profiling; Hirudo medicinalis; Leeches; Membrane Proteins; Neoplasm Proteins; Nerve Tissue Proteins; Proteomics; Salivary Glands; blood clotting inhibitor; transcriptome; membrane protein; nerve protein; tumor protein; animal tissue; Article; controlled study; gene cluster; gene expression profiling; gene ontology; head; Hirudo; Hirudo nipponia; immune-related gene; in situ hybridization; medicine; nonhuman; salivary gland; tissue specificity; tooth tissue; transcriptomics; animal; gene expression profiling; genetics; Hirudo medicinalis; leech; metabolism; proteomics; salivary gland | English | 2024 | 2024-05 | 10.1016/j.dci.2023.105125 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | Anemia in patients with IgA nephropathy: an impact on the prognosis of IgA nephropathy | Kim, Kyu Yeun; Park, Sun-Hee; Yoo, Jieun; Kim, Mingyu; Kim, Yoon-Ju; Jeon, You-Hyun; Lim, Jeong-Hoon; Jung, Hee-Yeon; Choi, Ji-Young; Cho, Jang-Hee; Kim, Chan Duck; Kim, Yong-Lim | Kyungpook Natl Univ Hosp, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Daegu, South Korea | Kim, Hyoungnae/JXN-1329-2024; Kim, Young/T-8521-2019; Park, Sun-Hee/LMN-0033-2024; Kim, Yong-Lim/AGK-3172-2022 | NEPHROLOGY DIALYSIS TRANSPLANTATION | NEPHROL DIAL TRANSPL | 0931-0509 | 1460-2385 | 39 | SCIE | TRANSPLANTATION;UROLOGY & NEPHROLOGY | 2024 | 5.6 | 8.1 | 0 | English | 2024 | 2024-05 | 바로가기 | 바로가기 |
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