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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Pixel-associated autoencoder for hyperspectral anomaly detection | Autoencoders (AEs) are central to hyperspectral anomaly detection, given their impressive efficacy. However, the current methodologies often neglect the global pixel similarity of the hyperspectral image (HsI), thereby limiting reconstruction accuracy. This study introduces an innovative pixel-associated AE approach that leverages pixel associations to augment hyperspectral anomaly detection. First, a dictionary construction methodology was introduced based on superpixel distance estimation to construct distinct dictionaries for background and local anomalies. Second, to recognize pixel similarities, the similarity metric of each pixel from the original HsI to the background dictionary and to the local anomaly dictionary was employed as the AE network input in lieu of the original HsI. Third, a dual hidden-layer feature similarity constraint network was proposed to enhance the reconstruction error of background and anomaly targets. Finally, the reconstruction error was utilized to score the anomaly target. The proposed method was benchmarked against other state-of-the-art techniques using synthetic and real HsI datasets to assess its effectiveness. The experimental results demonstrated the superior performance of the proposed method, outperforming the alternatives. | Xiang, Pei; Ali, Shahzad; Zhang, Jiajia; Jung, Soon Ki; Zhou, Huixin | Xidian Univ, Sch Phys, Xian 710071, Peoples R China; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea; Univ Melbourne, Sch Math & Stat, Melbourne 3010, Australia | ; Jung, Soon Ki/P-7687-2018; Ali, Shahzad/GPG-6925-2022 | 57208546864; 57709386500; 57214900846; 57226791905; 7404743079 | skjung@knu.ac.kr; | INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION | INT J APPL EARTH OBS | 1569-8432 | 1872-826X | 129 | SCIE | REMOTE SENSING | 2024 | 8.6 | 6.9 | 4.62 | 2025-05-07 | 14 | 15 | Anomaly detection; Autoencoder (AE); Hyperspectral image (HsI); Pixel similarity; Similarity metric | LOW-RANK; DECOMPOSITION; REPRESENTATION; DICTIONARY; GRAPH | Anomaly detection; Autoencoder (AE); Hyperspectral image (HsI); Pixel similarity; Similarity metric | accuracy assessment; data set; error analysis; estimation method; pixel | English | 2024 | 2024-05 | 10.1016/j.jag.2024.103816 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Resistant starch-enriched brown rice exhibits prebiotic properties and enhances gut health in obese mice | Resistant starch serves as a prebiotic in the large intestine, aiding in the maintenance of a healthy intestinal environment and mitigating associated chronic illnesses. This study aimed to investigate the impact of resistant starch-enriched brown rice (RBR) on intestinal health and functionality. We assessed changes in resistant starch concentration, structural alterations, and branch chain length distribution throughout the digestion process using an in vitro model. The efficacy of RBR in the intestinal environment was evaluated through analyses of its prebiotic potential, effects on intestinal microbiota, and intestinal function-related proteins in obese animals fed a high-fat diet. RBR exhibited a higher yield of insoluble fraction in both the small and large intestines compared to white and brown rice. The total digestible starch content decreased, while the resistant starch content significantly increased during in vitro digestion. Furthermore, RBR notably enhanced the growth of four probiotic strains compared to white and brown rice, displaying higher proliferation activity than the positive control, FOS. Notably, consumption of RBR by high-fat diet-induced obese mice suppressed colon shortening, increased Bifidobacteria growth, and improved intestinal permeability. These findings underscore the potential prebiotic and gut health-promoting attributes of RBR, offering insights for the development of functional foods aimed at preventing gastrointestinal diseases. | Park, Miri; Lee, Hye-Bin; Kim, Ha Ram; Kang, Min-Cheol; Jeong, Duyun; Choi, Hee-Don; Hong, Jung Sun; Park, Ho-Young | Korea Food Res Inst, Food Funct Res Div, Wanju Gun 55365, South Korea; Korea Food Res Inst, Food Convergence Res Div, Wanju Gun 55365, South Korea; Kyungpook Natl Univ, Dept Food & Food Serv Ind, Sangju 37224, South Korea; Univ Sci & Technol, Dept Food Biotechnol, Daejeon 34113, South Korea; 245 Nongsaenmyeong Ro, Wonju Gun 55365, Jeollabuk Do, South Korea | 55937173200; 57196420673; 56185982800; 55453173400; 57203059723; 24398302200; 56525714400; 55879476100 | hypark@kfri.re.kr; | FOOD RESEARCH INTERNATIONAL | FOOD RES INT | 0963-9969 | 1873-7145 | 187 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2024 | 8 | 6.9 | 2.44 | 2025-05-07 | 9 | 10 | Prebiotics; In vitro digestion; Resistant starch-enhanced brown rice; Gut barrier; Intestinal health | IN-VITRO DIGESTION; DIGESTIBILITY; ANTIOXIDANT | Gut barrier; In vitro digestion; Intestinal health; Prebiotics; Resistant starch-enhanced brown rice | Animals; Bifidobacterium; Diet, High-Fat; Digestion; Gastrointestinal Microbiome; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Oryza; Prebiotics; Probiotics; Resistant Starch; Starch; Mammals; Probiotics; prebiotic agent; probiotic agent; resistant starch; starch; Brown rice; Gut barrier; Gut healths; In-vitro digestions; Intestinal healths; Large intestine; Obese mice; Prebiotics; Resistant starch; Resistant starch-enhanced brown rice; animal; Bifidobacterium; C57BL mouse; chemistry; digestion; drug effect; growth, development and aging; intestine flora; lipid diet; male; metabolism; mouse; mouse mutant; obesity; Oryza; Starch | English | 2024 | 2024-07 | 10.1016/j.foodres.2024.114417 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Selective Biofilm Inhibition through Mucin-Inspired Engineering of Silk Glycopolymers | Mucins are key components of innate immune defense and possess remarkable abilities to manage pathogenic microbes while supporting beneficial ones and maintaining microbial homeostasis at mucosal surfaces. Their unique properties have garnered significant interest in developing mucin-inspired materials as novel therapeutic strategies for selectively controlling pathogens without disrupting the overall microbial ecology. However, natural mucin production is challenging to scale, driving the need for simpler materials that reproduce mucin's bioactivity. In this work, we generated silk-based glycopolymers with different monosaccharides (GalNAc, GlcNAc, NeuNAc, GlcN, and GalN) and different grafting densities. Using the oral cavity as a model system, we treated in vitro cultures of pathogenic Streptococcus mutans and commensal Streptococcus sanguinis with our glycopolymers, finding that silk-tethered GalNAc uniquely prevented biofilm formation without affecting overall bacterial growth of either species. This relatively simple material reproduced mucin's virulence-neutralizing effects while maintaining biocompatibility. These mucin-inspired materials represent a valuable tool for preventing infection-related harm and offer a strategy for the domestication of pathogens in other environments. | Werlang, Caroline Andrea; Sahoo, Jugal Kishore; Carcarmo-Oyarce, Gerado; Stevens, Corey; Uzun, Deniz; Putnik, Rachel; Hasturk, Onur; Choi, Jaewon; Kaplan, David L.; Ribbeck, Katharina | MIT, Dept Biol Engn, Cambridge, MA 02139 USA; Tufts Univ, Dept Biomed Engn, Sci & Technol Ctr, Medford, MA 02155 USA; Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu 41566, South Korea | Sahoo, Jugal/B-7073-2011; Sahoo, Jugal Kishore/B-7073-2011 | 55579845200; 36537731100; 57205585788; 56844499700; 59352407200; 57194276566; 57192118372; 57210206972; 56446221300; 6603290897 | david.kaplan@tufts.edu;ribbeck@mit.edu; | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | J AM CHEM SOC | 0002-7863 | 1520-5126 | 146 | 50 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2024 | 15.6 | 6.9 | 0.24 | 2025-05-07 | 1 | 1 | STREPTOCOCCUS-MUTANS; PROTEIN; VISCOSITY; SURFACES; SALIVA | Biofilms; Humans; Mucins; Silk; Streptococcus; Streptococcus mutans; Streptococcus sanguis; Abiotic; Biofilms; Biotic; Pathogens; mucin; polymer; silk fibroin; silk; Biofilm inhibitions; Glycopolymers; Homoeostasis; Immune defense; Innate immunes; Microbials; Mucosal surface; Pathogenic microbes; Property; Simple++; amino acid composition; antimicrobial activity; Article; bacterial growth; bacterial virulence; biocompatibility; biofilm; biological activity; biomass; coinfection; confocal microscopy; controlled study; cross linking; diagnostic test accuracy study; ecology; glycosylation; homeostasis; human; human cell; immunity; molecular weight; scanning electron microscopy; Streptococcus mutans; Streptococcus sanguinis; chemistry; drug effect; metabolism; Streptococcus; Streptococcus mutans; Silk | English | 2024 | 2024-12-09 | 10.1021/jacs.4c12945 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A population-based cohort study of longitudinal change of high-density lipoprotein cholesterol impact on gastrointestinal cancer risk | High-density Lipoprotein Cholesterol (HDL-C) levels have been associated with cancer. In this observational population-based cohort study using data from the Korean National Health Insurance Service system, we investigate the impact of longitudinal changes in HDL-C levels on gastrointestinal cancer risk. Individuals who underwent health examinations in 2010 and 2014 were followed-up through 2021. Among 3.131 million, 40696 gastric, 35707 colorectal, 21309 liver, 11532 pancreatic, 4225 gallbladder, and 7051 biliary cancers are newly detected. The persistent low HDL-C group increases the risk of gastric, liver, and biliary cancer comparing to persistent normal HDL-C group. HDL-C change from normal to low level increases the risk for gastric, colorectal, liver, pancreatic, gallbladder, and biliary cancers. Effects of HDL-C change on the gastrointestinal cancer risk are also modified by sex and smoking status. HDL-C changes affect the gastric and gallbladder cancer risk in age >= 60 years and the pancreatic and biliary cancer risk in age <60 years. Here, we show persistently low HDL-C and normal-to-low HDL-C change increase gastrointestinal cancer risk with discrepancies by sex, smoking status, and age. | Nam, Su Youn; Jo, Junwoo; Cho, Chang-Min | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Div Gastroenterol, Daegu, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea | 55617028500; 57210425017; 57158287600 | nam20131114@gmail.com; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 1.54 | 2025-05-07 | 7 | 6 | BODY-MASS INDEX; METABOLIC SYNDROME; HDL-CHOLESTEROL; BREAST-CANCER; METAANALYSIS | Cholesterol, HDL; Cohort Studies; Colorectal Neoplasms; Gastrointestinal Neoplasms; Humans; Middle Aged; Risk Factors; high density lipoprotein cholesterol; high density lipoprotein cholesterol; cancer; health risk; risk factor; smoking; adult; age; Article; biliary tract cancer; cancer risk; clinical evaluation; cohort analysis; colorectal cancer; comparative study; controlled study; demographics; disease association; female; follow up; gallbladder cancer; gastrointestinal cancer; human; Korean national health insurance service system; liver cancer; longitudinal change; major clinical study; male; medical examination; medical parameters; middle aged; people by smoking status; population based cohort study; stomach cancer; colorectal tumor; gastrointestinal tumor; risk factor | English | 2024 | 2024-04-04 | 10.1038/s41467-024-47193-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Astrocytic inhibition of lateral septal neurons promotes diverse stress responses | Inhibitory neuronal circuits within the lateral septum (LS) play a key role in regulating mood and stress responses. Even though glial cells can modulate these circuits, the impact of astrocytes on LS neural circuits and their functional interactions remains largely unexplored. Here, we demonstrate that astrocytes exhibit increased intracellular Ca-2 levels in response to aversive sensory and social stimuli in both male and female mice. This astrocytic Ca-2 elevation inhibits neighboring LS neurons by reducing excitatory synaptic transmissions through A1R-mediated signaling in both the dorsal (LSd) and intermediate LS (LSi) and enhancing inhibitory synaptic transmission via A2AR-mediated signaling in the LSi. At the same time, astrocytes reduce inhibitory tone on distant LS neurons. In the LSd, astrocytes promote social avoidance and anxiety, as well as increased heart rate in socially stressed male mice. In contrast, astrocytes in the LSi contribute to elevated heart rate and heightened blood corticosterone levels in unstressed male mice. These results suggest that the dynamic interactions between astrocytes and neurons within the LS modulate physiological and behavioral responses to stressful experiences. The lateral septum contains neurons that mediate stress responses, but the role of astrocytes remained unclear. Here, the authors show that lateral septum astrocytes modulate nearby neurons and enhance stress related physiological and behavioral responses. | Seo, Kain; Won, Sanghyun; Lee, Hee-Yoon; Sin, Yeonju; Lee, Sangho; Park, Hyejin; Kim, Yong Geon; Yang, Seo Young; Kim, Dong-Jae; Suk, Kyoungho; Koo, Ja Wook; Baek, Myungin; Choi, Se-Young; Lee, Hyosang | Daegu Gyeongbuk Inst Sci & Technol DGIST, Dept Brain Sci, Daegu, South Korea; Daegu Gyeongbuk Inst Sci & Technol DGIST, Convergence Res Adv Ctr Olfact, Daegu, South Korea; Seoul Natl Univ, Dent Res Inst, Sch Dent, Dept Physiol & Neurosci, Seoul, South Korea; Daegu Gyeongbuk Inst Sci & Technol DGIST, Lab Anim Resource Ctr, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Sch Med, Dept Pharmacol, Daegu, South Korea; Korea Brain Res Inst KBRI, Emot Cognit & Behav Res Grp, Daegu, South Korea; Korea Brain Res Inst KBRI, Daegu, South Korea | ; Choi, Se Young/AEB-2770-2022; Koo, Ja/G-9317-2011 | 57195681754; 59417982600; 57217066022; 57397222200; 57202504463; 59418111400; 59418498500; 59418498600; 58187315200; 7005114595; 7203084147; 26638648700; 7408122846; 56101818800 | sychoi@snu.ac.kr;hyosang22@dgist.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0.62 | 2025-05-07 | 3 | 3 | NUCLEUS; TRANSMISSION; CONNECTIONS; CIRCUIT | Animals; Anxiety; Astrocytes; Calcium; Corticosterone; Female; Heart Rate; Male; Mice; Mice, Inbred C57BL; Neurons; Septal Nuclei; Stress, Psychological; Synaptic Transmission; adenosine receptor; calcium ion; calcium; corticosterone; behavioral response; blood; cell; inhibition; neurology; signaling; animal experiment; animal model; animal tissue; anxiety; Article; astrocyte; behavior; chronic social defeat; controlled study; corticosterone blood level; heart rate; hippocampus; lateral septal nucleus; male; mouse; nerve cell; nerve cell network; nonhuman; physiological stress; social avoidance; synaptic transmission; animal; blood; C57BL mouse; female; mental stress; metabolism; nerve cell; pathophysiology; physiology; septum nucleus | English | 2024 | 2024-11-21 | 10.1038/s41467-024-54376-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Erratum | Correction to: Kondo interaction in FeTe and its potential role in the magnetic order (Nature Communications, (2023), 14, 1, (4145), 10.1038/s41467-023-39827-1) | Correction to: Nature Communicationshttps://doi.org/10.1038/s41467-023-39827-1, published online 12 July 2023 In this article the affiliation details for Young Jai Choi were incorrectly given as ‘Stanford Synchrotron Radiation Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA’ but should have been ‘Department of Physics, Yonsei University, Seoul 03021, Korea’. The original article has been corrected. © The Author(s) 2024. | Kim, Younsik; Kim, Min-Seok; Kim, Dongwook; Kim, Minjae; Kim, Minsoo; Cheng, Cheng-Maw; Choi, Joonyoung; Jung, Saegyeol; Lu, Donghui; Kim, Jong Hyuk; Cho, Soohyun; Song, Dongjoon; Oh, Dongjin; Yu, Li; Choi, Young Jai; Kim, Hyeong-Do; Han, Jung Hoon; Jo, Younjung; Shim, Ji Hoon; Seo, Jungpil; Huh, Soonsang; Kim, Changyoung | Center for Correlated Electron Systems, Institute for Basic Science, Seoul, 08826, South Korea, Department of Physics & amp; Seoul National University, Seoul, 08826, South Korea; Department of Emerging Materials Science, DGIST, Daegu, 42988, South Korea; Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea; Korea Institute for Advanced Study, Seoul, 02455, South Korea; Center for Correlated Electron Systems, Institute for Basic Science, Seoul, 08826, South Korea, Department of Physics & amp; Seoul National University, Seoul, 08826, South Korea; National Synchrotron Radiation Research Center, Hsinchu, 30076, Taiwan; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Center for Correlated Electron Systems, Institute for Basic Science, Seoul, 08826, South Korea, Department of Physics & amp; Seoul National University, Seoul, 08826, South Korea; Stanford Synchrotron Radiation Light Source, SLAC National Accelerator Laboratory, Menlo Park, 94025, CA, United States; Department of Physics, Yonsei University, Seoul, 03021, South Korea; Center for Excellence in Superconducting Electronics, State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050, China; Center for Correlated Electron Systems, Institute for Basic Science, Seoul, 08826, South Korea, Department of Physics & amp; Seoul National University, Seoul, 08826, South Korea; Center for Correlated Electron Systems, Institute for Basic Science, Seoul, 08826, South Korea, Department of Physics & amp; Seoul National University, Seoul, 08826, South Korea, Department of Physics, Massachusetts Institute of Technology, Cambridge, 02139, MA, United States; Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China, School of Physical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China, Songshan Lake Materials Laboratory, Guangdong, Dongguan, 523808, China; Department of Physics, Yonsei University, Seoul, 03021, South Korea; XFEL Beamline Division, Pohang Accelerator Laboratory, Pohang, 37673, South Korea; Department of Physics, Sungkyunkwan University, Suwon, 16419, South Korea; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea; Department of Emerging Materials Science, DGIST, Daegu, 42988, South Korea; Center for Correlated Electron Systems, Institute for Basic Science, Seoul, 08826, South Korea, Department of Physics & amp; Seoul National University, Seoul, 08826, South Korea; Center for Correlated Electron Systems, Institute for Basic Science, Seoul, 08826, South Korea, Department of Physics & amp; Seoul National University, Seoul, 08826, South Korea | 57218459973; 57218082191; 57075225100; 56084817400; 59072942100; 23468425500; 57199099536; 57222181997; 7403079713; 57193568510; 57193743010; 21743444000; 57214245779; 55737417100; 26535632200; 8217995100; 36487931400; 13502586500; 57281457100; 9640324600; 57190669651; 35264213600 | sshuhss@gmail.com;changyoung@snu.ac.kr; | Nature Communications | NAT COMMUN | N/A | 2041-1723 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0 | 2025-05-07 | 0 | article; drug therapy; Korea; South Korea; synchrotron radiation; United States; controlled study; erratum; human | English | Final | 2024 | 10.1038/s41467-024-46779-7 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | Article | Cryogenic III-V and Nb electronics integrated on silicon for large-scale quantum computing platforms | Quantum computers now encounter the significant challenge of scalability, similar to the issue that classical computing faced previously. Recent results in high-fidelity spin qubits manufactured with a Si CMOS technology, along with demonstrations that cryogenic CMOS-based control/readout electronics can be integrated into the same chip or die, opens up an opportunity to break out the challenges of qubit size, I/O, and integrability. However, the power consumption of cryogenic CMOS-based control/readout electronics cannot support thousands or millions of qubits. Here, we show that III–V two-dimensional electron gas and Nb superconductor-based cryogenic electronics can be integrated with Si and operate at extremely low power levels, enabling the control and readout for millions of qubits. Our devices offer a unity gain cutoff frequency of 601 GHz, a unity power gain cutoff frequency of 593 GHz, and a low noise indication factor IDgm−1 of 0.21VmmS−1 at 4 K using more than 10 times less power consumption than CMOS. © The Author(s) 2024. | Jeong, Jaeyong; Kim, Seong Kwang; Suh, Yoon-Je; Lee, Jisung; Choi, Joonyoung; Kim, Joon Pyo; Kim, Bong Ho; Park, Juhyuk; Shim, Joonsup; Rheem, Nahyun; Lee, Chan Jik; Jo, Younjung; Geum, Dae-Myeong; Park, Seung-Young; Kim, Jongmin; Kim, Sanghyeon | School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea; School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea; School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea; Center for Scientific Instrumentation, Korea Basic Science Institute (KBSI), Daejeon, South Korea; Department of Physics, Kyungpook National University (KNU), Daegu, South Korea; School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea; School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea; School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea; School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea; School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea; School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea; Department of Physics, Kyungpook National University (KNU), Daegu, South Korea; Department of Electrical Engineering, Inha University, Incheon, South Korea; Center for Scientific Instrumentation, Korea Basic Science Institute (KBSI), Daejeon, South Korea; Division of Device Technology, Korea Advanced Nano Fab Center (KANC), Suwon, South Korea; School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea | 57222569322; 57149020800; 57218557470; 57192440339; 57199099536; 57233285700; 57199939841; 57223148768; 57216335621; 58897747500; 58651290800; 13502586500; 55960346100; 36682812900; 56468989500; 57205232256 | shkim.ee@kaist.ac.kr; | Nature Communications | NAT COMMUN | N/A | 2041-1723 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0.62 | 2025-05-07 | 2 | quantum dot; silicon; detection method; electron; quantum mechanics; silicon; superconductivity; wavelength; Article; electric potential; electron; noise; article; controlled study; electronics; male; superconductor | English | Final | 2024 | 10.1038/s41467-024-55077-1 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Directed crystallization of a poly(3,4-ethylenedioxythiophene) film by an iron(III) dodecyl sulfate lamellar superstructure | Poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), a successfully commercialized polymeric semiconductor material, has potential as a transparent electrode in flexible electronic devices, yet has insufficient conductivity. We present the synthesis, properties, and directed crystallization of the PEDOT:dodecyl sulfate (PEDOT:DS) film. Iron(III) dodecyl sulfate (Fe(DS)(3)) multi-lamellar vesicles (MLVs), a new growth template, are used to synthesize and direct the growth of the PEDOT:DS film via vapor-phase polymerization of 3,4-ethylenedioxythiophene to form huge PEDOT:DS co-crystal domains within the MLV superstructure. The polycrystalline film has metallic conductivity (avg. similar to 1.0 x 10(4) S cm(-1)), is highly transparent and mechanically durable yet flexible, and suitable for next-generation flexible electronics. These noteworthy properties are conferred by the MLV lamellar superstructure of Fe(DS)(3), a selective oxidant and an efficient in situ dopant that enhances the film hydrophobicity and durability. Sophisticated MLV-type oxidants are foreseen to enable the synthesis of more conductive, transparent, robust, flexible, and water-stable polymer electrode materials in future. | Ma, Feng; Choi, Sang-il; Lee, Dooyong; Jeon, Sung Bae; Park, Sungkyun; Cho, Sung-Pyo; Boo, Jin-Hyo; Kim, Sungsoo | Paichai Univ, Dept Mat Engn, Daejeon, South Korea; Kyungpook Natl Univ, Dept Phys Educ, Daegu, South Korea; Pusan Natl Univ, Dept Phys, Busan, South Korea; Seoul Natl Univ, Natl Ctr Interuniv Res Facil, Seoul, South Korea; Adv Inst Convergence Technol, Graphene Res Ctr, Suwon, South Korea; Sungkyunkwan Univ, Dept Chem, Suwon, South Korea; Hunan Univ Arts & Sci, Sch Chem & Mat Engn, Changde, Hunan, Peoples R China | ; Choi, Sangil/N-7571-2013 | 57224625026; 56823949500; 56199505400; 59332711700; 10539429300; 7404885359; 7004586233; 57196226565 | skim@pcu.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0.92 | 2025-05-07 | 6 | 6 | VAPOR-PHASE POLYMERIZATION; PEDOT; CONDUCTIVITY; GRAPHENE; SURFACTANT; LAYERS | dodecyl sulfate; ferric ion; poly (3,4 ethylenedioxythiophene); thiophene derivative; unclassified drug; polymer; polystyrenesulfonate sodium; polystyrenesulfonic acid; biofilm; crystallization; electrode; hydrophobicity; iron; oxidant; polymerization; sulfate; Article; contact angle; controlled study; crystallization; differential scanning calorimetry; field emission scanning electron microscopy; high resolution transmission electron microscopy; hydrophobicity; moisture; polymerization; radiation scattering; synchrotron radiation; synthesis; thermogravimetry; thermostability; transmission electron microscopy; X ray diffraction; X ray photoemission spectroscopy; article; conductance; drug analysis; electrode; semiconductor; vapor; water | English | 2024 | 2024-09-16 | 10.1038/s41467-024-51621-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Discovery of a peripheral 5HT2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis | Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is currently the leading cause of chronic liver disease worldwide. Metabolic Dysfunction-Associated Steatohepatitis (MASH), an advanced form of MASLD, can progress to liver fibrosis, cirrhosis, and hepatocellular carcinoma. Based on recent findings by our team that liver 5HT(2A )knockout male mice suppressed steatosis and reduced fibrosis-related gene expression, we developed a peripheral 5HT(2A) antagonist, compound 11c for MASH. It shows good in vitro activity, stability, and in vivo pharmacokinetics (PK) in rats and dogs. Compound 11c also shows good in vivo efficacy in a diet-induced obesity (DIO) male mice model and in a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) male mice model, effectively improving histologic features of MASH and fibrosis. According to the tissue distribution study using [14C]-labeled 11c, the compound was determined to be a peripheral 5HT(2A) antagonist. Collectively, first-in-class compound 11c shows promise as a therapeutic agent for the treatment of MASLD and MASH. | Pagire, Haushabhau S.; Pagire, Suvarna H.; Jeong, Byung-kwan; Choi, Won-Il; Oh, Chang Joo; Lim, Chae Won; Kim, Minhee; Yoon, Jihyeon; Kim, Seong Soon; Bae, Myung Ae; Jeon, Jae-Han; Song, Sungmin; Lee, Hee Jong; Lee, Eun Young; Goughnour, Peter C.; Kim, Dooseop; Lee, In-Kyu; Loomba, Rohit; Kim, Hail; Ahn, Jin Hee | Gwangju Inst Sci & Technol, Dept Chem, Gwangju 61005, South Korea; JD Biosci Inc, TJS Knowledge Ind Ctr, Suite 801,208 Beon Gil Cheomdangwagi Ro, Gwangju 61011, South Korea; Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Med, Res Inst Aging & Metab, Daegu 41404, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet &, Daegu 41404, South Korea; Korea Res Inst Chem Technol, Bio & Drug Discovery Div, Daejeon 34114, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu 41404, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Univ Calif San Diego, NAFLD Res Ctr, Dept Med, Div Gastroenterol & Hepatol, La Jolla, CA 92093 USA; Korea Adv Inst Sci & Technol KAIST, Biomed Res Ctr, Daejeon 34141, South Korea | ; Loomba, Rohit/AAE-7831-2019; Kim, Hail/C-5608-2018; Ahn, Jin/C-6122-2019; Kim, Seong Soon/IZE-2538-2023; CHOI, WON/J-1665-2012 | 55599893000; 56716279400; 57194457149; 57191264924; 14049080600; 58158274300; 57723465700; 57216544129; 57194944619; 7005711682; 36910340400; 58819672300; 57216548394; 59505515200; 57188575442; 56714067000; 36071537600; 12751805200; 7410126420; 56714432600 | hailkim@kaist.edu;jhahn@gist.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0.92 | 2025-05-07 | 4 | 4 | NONALCOHOLIC STEATOHEPATITIS; SEROTONIN SYNTHESIS; LIVER-DISEASE; OPTIMIZATION; RECEPTOR; DESIGN | Animals; Dogs; Fatty Liver; Liver Cirrhosis; Liver Neoplasms; Male; Mice; Mice, Knockout; Musculoskeletal Physiological Phenomena; Rats; serotonin 2A antagonist; diet; disease; gene; gene expression; obesity; protein; animal experiment; animal model; Article; beagle; choline deficiency; controlled study; diet-induced obesity; drug efficacy; drug labeling; drug mechanism; drug potency; drug selectivity; drug stability; drug structure; gene expression; histopathology; in vitro study; in vivo study; lipid diet; liver fibrosis; male; medical history; metabolic dysfunction-associated steatohepatitis; metabolic dysfunction-associated steatohepatitis; molecular docking; mouse; nonhuman; rat; steatohepatitis; tissue distribution; toxicity testing; animal; dog; fatty liver; knockout mouse; liver cirrhosis; liver tumor; musculoskeletal function | English | 2024 | 2024-01-20 | 10.1038/s41467-024-44874-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Durvalumab plus pazopanib combination in patients with advanced soft tissue sarcomas: a phase II trial | We aimed to determine the activity of the anti-VEGF receptor tyrosine-kinase inhibitor, pazopanib, combined with the anti-PD-L1 inhibitor, durvalumab, in metastatic and/or recurrent soft tissue sarcoma (STS). In this single-arm phase 2 trial (NCT03798106), treatment consisted of pazopanib 800 mg orally once a day and durvalumab 1500 mg once every 3 weeks. Primary outcome was overall response rate (ORR) and secondary outcomes included progression-free survival (PFS), overall survival, disease control rate, immune-related response criteria, and safety. The ORR was 30.4% and the trial met the pre-specified endpoint. The median PFS was 7.7 months (95% confidence interval: 5.7-10.4). The common treatment-related adverse events of grades 3-4 included neutropenia (9 [19.1%]), elevated aspartate aminotransferase (7 [14.9%]), alanine aminotransferase (5 [10.6%]), and thrombocytopenia (4 [8.5%]). In a prespecified transcriptomic analysis, the B lineage signature was a significant key determinant of overall response (P = 0.014). In situ analysis also showed that tumours with high CD20+ B cell infiltration and vessel density had a longer PFS (P = 6.5 x 10-4) than those with low B cell infiltration and vessel density, as well as better response (50% vs 12%, P = 0.019). CD20+ B cell infiltration was identified as the only independent predictor of PFS via multivariate analysis. Durvalumab combined with pazopanib demonstrated promising efficacy in an unselected STS cohort, with a manageable toxicity profile. Response rates to immune-checkpoint inhibitors in patients with advanced sarcoma remain modest. Here the authors report the results of a phase 2 study of durvalumab (anti-PD-L1) in combination with the anti-VEGF receptor tyrosine-kinase inhibitor pazopanib in unselected advanced sarcomas with correlative genomic analysis. | Cho, Hee Jin; Yun, Kum-Hee; Shin, Su-Jin; Lee, Young Han; Kim, Seung Hyun; Baek, Wooyeol; Han, Yoon Dae; Kim, Sang Kyum; Ryu, Hyang Joo; Lee, Joohee; Cho, Iksung; Go, Heounjeong; Ko, Jiwon; Jung, Inkyung; Jeon, Min Kyung; Rha, Sun Young; Kim, Hyo Song | Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, CMRI, Daegu, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Div Med Oncol, Seoul, South Korea; Yonsei Univ, Gangnam Severance Hosp, Coll Med, Dept Pathol, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Radiol, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Orthopaed Surg, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Plast Surg, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Surg, Seoul, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Dept Pathol, Seoul, South Korea; Yonsei Univ, Coll Med, Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul, South Korea; Asan Med Ctr, Asan Inst Life Sci, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Biomed Syst Informat, Div Biostat, Seoul, South Korea | ; Han, Yoondae/W-1325-2019; Jung, Inkyung/Q-2018-2016; Lee, Jeong Hoon/AAF-2400-2020; KIM, JIN/I-6927-2019; Kim, Hyun/D-5568-2011; Lee, Yo Han/IUN-3410-2023; Shin, Su-Jin/KPB-2645-2024 | 55937716400; 57219005117; 57189709813; 57225667591; 57284252700; 56990792600; 58826156400; 55877447800; 57196218485; 57911827200; 26643662100; 57204538826; 57222964743; 16039030000; 59026454100; 7006023235; 57226091353 | hyosong77@yuhs.ac; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 4.62 | 2025-05-07 | 19 | 18 | METASTATIC SARCOMA; 1ST-LINE TREATMENT; OPEN-LABEL; MULTICENTER; GEMCITABINE; LIPOSARCOMA; DOXORUBICIN; IPILIMUMAB; EXPRESSION; DOCETAXEL | Antibodies, Monoclonal; Humans; Indazoles; Neoplasm Recurrence, Local; Pyrimidines; Sarcoma; Soft Tissue Neoplasms; Sulfonamides; alanine aminotransferase; aspartate aminotransferase; docetaxel; doxorubicin; durvalumab; eribulin; gemcitabine; ifosfamide; pazopanib; vasculotropin; durvalumab; indazole derivative; monoclonal antibody; pazopanib; pyrimidine derivative; sulfonamide; cell; disease control; immune response; infiltration; survival; toxicity; adult; advanced cancer; alveolar soft part sarcoma; Article; blood vessel density; cell infiltration; clinical article; clinical outcome; controlled study; drug activity; female; human; immune related response criteria; immunohistochemistry; immunosuppressive treatment; male; microenvironment; multiple cycle treatment; neoplastic cell transformation; neutropenia; oral drug administration; overall response rate; overall survival; phase 2 clinical trial; progression free survival; renal cell carcinoma; side effect; soft tissue sarcoma; thrombocytopenia; treatment response; tumor microenvironment; tumor mutational burden; clinical trial; sarcoma; soft tissue tumor; tumor recurrence | English | 2024 | 2024-01-23 | 10.1038/s41467-024-44875-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | High Salinity Shelf Water production rates in Terra Nova Bay, Ross Sea from high-resolution salinity observations | High Salinity Shelf Water (HSSW) formed in the Ross Sea of Antarctica is a precursor to Antarctic Bottom Water (AABW), a water mass that constitutes the bottom limb of the global overturning circulation. HSSW production rates are poorly constrained, as in-situ observations are scarce. Here, we present high-vertical-and-temporal-resolution salinity time series collected in austral winter 2017 from a mooring in Terra Nova Bay (TNB), one of two major sites of HSSW production in the Ross Sea. We calculate an annual-average HSSW production rate of similar to 0.4 Sv (10(6) m(3) s(-1)), which we use to ground truth additional estimates across 2012-2021 made from parametrized net surface heat fluxes. We find sub-seasonal and interannual variability on the order of 0.1 Sv, with a strong dependence on variability in open-water area that suggests a sensitivity of TNB HSSW production rates to changes in the local wind regime and offshore sea ice pack. | Miller, Una Kim; Zappa, Christopher J.; Gordon, Arnold L.; Yoon, Seung-Tae; Stevens, Craig; Lee, Won Sang | Columbia Univ, Lamont Doherty Earth Observ, Palisades, NY 10964 USA; Kyungpook Natl Univ, Daegu, South Korea; Natl Inst Water & Atmospher Res, Wellington, New Zealand; Univ Auckland, Auckland, New Zealand; Korea Polar Res Inst, Incheon, South Korea | ; Yoon, Seung-Tae/GXV-4573-2022; Gordon, Arnold/H-1049-2011; Gordon, Arnold L./H-1049-2011 | 56458341400; 6602623584; 7402141938; 37015068400; 7402089802; 55713048700 | ukm2103@columbia.edu; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 2.16 | 2025-05-07 | 9 | 8 | ANTARCTIC BOTTOM WATER; SURFACE-TEMPERATURE IMAGERY; HEAT-FLUX; ICE PRODUCTION; SENSIBLE HEAT; BULK PARAMETERIZATION; PASSIVE MICROWAVE; COASTAL POLYNYAS; KATABATIC WINDS; SOUTHERN-OCEAN | Antarctica; East Antarctica; Terra Nova Bay; water; Antarctic Bottom Water; heat flux; sea surface salinity; time series analysis; water mass; winter; air temperature; Article; freezing point; heat transfer; humidity; ice cover; ice shelf; nonhuman; radiation; Ross Sea; salinity; satellite imagery; sea ice; time series analysis; wind speed; Antarctica; article; controlled study; ice pack; wind; winter | English | 2024 | 2024-01-16 | 10.1038/s41467-023-43880-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | In-depth correlation analysis between tear glucose and blood glucose using a wireless smart contact lens | Tears have emerged as a promising alternative to blood for diagnosing diabetes. Despite increasing attempts to measure tear glucose using smart contact lenses, the controversy surrounding the correlation between tear glucose and blood glucose still limits the clinical usage of tears. Herein, we present an in-depth investigation of the correlation between tear glucose and blood glucose using a wireless and soft smart contact lens for continuous monitoring of tear glucose. This smart contact lens is capable of quantitatively monitoring the tear glucose levels in basal tears excluding the effect of reflex tears which might weaken the relationship with blood glucose. Furthermore, this smart contact lens can provide an unprecedented level of continuous tear glucose data acquisition at sub-minute intervals. These advantages allow the precise estimation of lag time, enabling the establishment of the concept called 'personalized lag time'. This demonstration considers individual differences and is successfully applied to both non-diabetic and diabetic humans, as well as in animal models, resulting in a high correlation. | Park, Wonjung; Seo, Hunkyu; Kim, Jeongho; Hong, Yeon-Mi; Song, Hayoung; Joo, Byung Jun; Kim, Sumin; Kim, Enji; Yae, Che-Gyem; Kim, Jeonghyun; Jin, Jonghwa; Kim, Joohee; Lee, Yong-ho; Kim, Jayoung; Kim, Hong Kyun; Park, Jang-Ung | Yonsei Univ, Dept Mat Sci & Engn, Seoul 03722, South Korea; Yonsei Univ, Inst Basic Sci IBS, Ctr Nanomed, Seoul 03722, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu 41944, South Korea; Kyungpook Nat Univ, Dept Ophthalmol, Sch Med, Daegu 41944, South Korea; Kwangwoon Univ, Dept Elect Convergence Engn, Seoul 01897, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Korea Inst Sci & Technol, Ctr Bion, Biomed Res Div, Seoul 02792, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul 03722, South Korea; Yonsei Univ, Inst Endocrine Res, Coll Med, Seoul 03722, South Korea; Severance Hosp, Inst Innovat Digital Healthcare IIDH, Seoul 03722, South Korea; Yonsei Univ, Coll Med, Dept Med Engn, Seoul 03722, South Korea; Kyungpook Natl Univ Hosp, Dept Ophthalmol, Daegu 41944, South Korea; Yonsei Univ, Coll Med, Dept Neurosurg, Seoul 03722, South Korea; Yonsei Univ, Adv Sci Inst, Grad Program Nano Biomed Engn NanoBME, Seoul 03722, South Korea | Kim, Hong Kyun/ITT-7758-2023; Lee, Yong-ho/AAT-4106-2020; Park, Jang-Ung/E-9224-2010; Kim, Jayoung/NKO-9807-2025 | 57410336100; 57217280976; 57219385573; 58663176500; 57844139600; 57222706899; 57898467900; 57222373672; 56048982200; 57203325076; 57223246243; 57208530366; 56424219700; 56103241400; 57218260940; 11739935500 | joohee710610@kist.re.kr;yholee@yuhs.ac;jayoungkim@yonsei.ac.kr;okeye@knu.ac.kr;jang-ung@yonsei.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 7.08 | 2025-05-07 | 36 | 34 | NONINVASIVE DETECTION; BIOSENSOR; SENSOR; FLUID | Animals; Blood Glucose; Contact Lenses, Hydrophilic; Diabetes Mellitus; Glucose; Humans; Tears; glucose; glucose oxidase; insulin; silastic; glucose; blood; correlation; data acquisition; diabetes; glucose; precision; adult; animal experiment; animal model; Article; chemical vapor deposition; chronoamperometry; comparative study; controlled study; correlation analysis; cyclic voltammetry; diabetes mellitus; diabetic patient; glucose blood level; glucose metabolism; histology; human; human cell; immunohistochemistry; insulin response; intravenous glucose tolerance test; mechanical stimulation; nonhuman; oral glucose tolerance test; room temperature; surface property; wireless communication; animal; chemistry; diabetes mellitus; glucose blood level; lacrimal fluid | English | 2024 | 2024-04-02 | 10.1038/s41467-024-47123-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination | The NS1 binding protein, known for interacting with the influenza A virus protein, is involved in RNA processing, cancer, and nerve cell growth regulation. However, its role in stress response independent of viral infections remains unclear. This study investigates NS1 binding protein's function in regulating stress granules during oxidative stress through interactions with GABARAP subfamily proteins. We find that NS1 binding protein localizes to stress granules, interacting with core components, GABARAP proteins, and p62, a protein involved in autophagy. In cells lacking NS1 binding protein, stress granule dynamics are altered, and p62 ubiquitination is increased, suggesting impaired stress granule degradation. Overexpression of NS1 binding protein reduces p62 ubiquitination. In amyotrophic lateral sclerosis patient-derived neurons, reduced NS1 binding protein and p62 disrupt stress granule morphology. These findings identify NS1 binding protein as a negative regulator of p62 ubiquitination and a facilitator of GABARAP recruitment to stress granules, implicating it in stress granule regulation and amyotrophic lateral sclerosis pathogenesis. | Jeon, Pureum; Ham, Hyun-Ji; Choi, Haneul; Park, Semin; Jang, Jae-Woo; Park, Sang-Won; Cho, Dong-Hyung; Lee, Hyun-Jeong; Song, Hyun Kyu; Komatsu, Masaaki; Han, Dohyun; Jang, Deok-Jin; Lee, Jin-A | Hannam Univ, Coll Life Sci & Nanotechnol, Dept Biol Sci & Biotechnol, Daejeon, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm, Dept Ecol Sci, Sangju, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRearch Grp, Daegu 41566, South Korea; Korea Univ, Dept Life Sci, Seoul, South Korea; Juntendo Univ, Grad Sch Med, Dept Physiol, Bunkyo Ku, Tokyo, Japan; Seoul Natl Univ Hosp, Dept Transdiciplinary Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Med, Seoul, South Korea | Park, Sang/J-5485-2012; Komatsu, Masaaki/B-8321-2011; Jang, Jae Woo/GNP-4131-2022; Han, Dohyun/AAU-7871-2020; Song, Hyun Kyu/D-6763-2016 | 57208213892; 57768440400; 57219743631; 57766982600; 57219744861; 57211486702; 58950702200; 59495775200; 7404037299; 7202792529; 7403219960; 22234503100; 35337365000 | jangdj@knu.ac.kr;leeja@hnu.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0.31 | 2025-05-07 | 2 | 1 | TRANSCRIPTION FACTOR NRF2; SELECTIVE AUTOPHAGY; P62/SQSTM1; DOMAINS | Adaptor Proteins, Signal Transducing; Amyotrophic Lateral Sclerosis; Apoptosis Regulatory Proteins; Autophagy; Cytoplasmic Granules; HEK293 Cells; HeLa Cells; Humans; Microtubule-Associated Proteins; Neurons; Oxidative Stress; Protein Binding; Sequestosome-1 Protein; Stress Granules; Ubiquitination; Viral Nonstructural Proteins; ataxin 2; binding protein; gabarap protein; nonstructural protein 1; nucleolysin TIA 1 isoform p40; polyadenylic acid binding protein; protein; Ras GTPase activating protein binding protein 1; sequestosome 1; unclassified drug; apoptosis regulatory protein; GABARAP protein, human; microtubule associated protein; NUB1 protein, human; protein binding; sequestosome 1; signal transducing adaptor protein; SQSTM1 protein, human; viral nonstructural protein; cell; gene expression; influenza; neurology; oxidative stress; protein; adult; aged; amyotrophic lateral sclerosis; Article; cell count; cell size; cell structure; coimmunoprecipitation; controlled study; embryo; female; gene knockout; human; human cell; induced pluripotent stem cell; liquid chromatography-mass spectrometry; male; middle aged; molecular dynamics; motoneuron; oxidative stress; pathogenesis; phenotype; protein function; protein localization; protein motif; protein protein interaction; selective autophagy; stress granule; ubiquitination; amyotrophic lateral sclerosis; cell granule; genetics; HEK293 cell line; HeLa cell line; metabolism; nerve cell; pathology | English | 2024 | 2024-12-30 | 10.1038/s41467-024-55446-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Overcoming bias in estimating epidemiological parameters with realistic history-dependent disease spread dynamics | Epidemiological parameters such as the reproduction number, latent period, and infectious period provide crucial information about the spread of infectious diseases and directly inform intervention strategies. These parameters have generally been estimated by mathematical models that involve an unrealistic assumption of history-independent dynamics for simplicity. This assumes that the chance of becoming infectious during the latent period or recovering during the infectious period remains constant, whereas in reality, these chances vary over time. Here, we find that conventional approaches with this assumption cause serious bias in epidemiological parameter estimation. To address this bias, we developed a Bayesian inference method by adopting more realistic history-dependent disease dynamics. Our method more accurately and precisely estimates the reproduction number than the conventional approaches solely from confirmed cases data, which are easy to obtain through testing. It also revealed how the infectious period distribution changed throughout the COVID-19 pandemic during 2020 in South Korea. We also provide a user-friendly package, IONISE, that automates this method. In infectious disease models, epidemiological parameters are typically estimated assuming a exponential distributions of latent and infectious periods. Here, the authors show that adapting models to incorporate Gamma distributions produces less biased estimates when applied to the example of the early COVID-19 pandemic in South Korea. | Hong, Hyukpyo; Eom, Eunjin; Lee, Hyojung; Choi, Sunhwa; Choi, Boseung; Kim, Jae Kyoung | Korea Adv Inst Sci & Technol, Dept Math Sci, Daejeon 34141, South Korea; Pioneer Res Ctr Math & Computat Sci, Inst Basic Sci, Biomed Math Grp, Daejeon 34126, South Korea; Korea Univ, Dept Econ Stat, Sejong 30019, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea; Natl Inst Math Sci, Innovat Ctr Ind Math, Seongnam 13449, South Korea; Korea Univ, Div Big Data Sci, Sejong 30019, South Korea; Ohio State Univ, Coll Publ Hlth, Columbus, OH 43210 USA; Univ Wisconsin Madison, Dept Math, Madison, WI 53706 USA | ; Choi, Sunhwa/D-8320-2011; Hong, Hyukpyo/JWO-7035-2024; Kim, Jae Kyoung/F-1297-2015 | 57223215809; 59361479700; 57196021198; 49961295500; 25026927400; 56150933800 | shchoi@nims.re.kr;cbskust@korea.ac.kr;jaekkim@kaist.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0 | 2025-05-07 | 0 | 0 | SEIR MODEL; VACCINATION; PERIOD; IMPACT | Basic Reproduction Number; Bayes Theorem; Bias; COVID-19; Epidemiological Models; Humans; Pandemics; Republic of Korea; SARS-CoV-2; South Korea; Bayesian analysis; COVID-19; disease spread; epidemiology; estimation method; infectious disease; parameter estimation; Article; compartment model; contact examination; controlled study; disease transmission; epidemiological monitoring; history; human; infection; latent period; mass gathering; mathematical model; nonhuman; reproduction; secondary infection; sensitivity analysis; simulation; South Korea; susceptible exposed infectious recovered model; basic reproduction number; Bayes theorem; coronavirus disease 2019; epidemiological model; epidemiology; isolation and purification; pandemic; Severe acute respiratory syndrome coronavirus 2; statistical bias; virology | English | 2024 | 2024-10-09 | 10.1038/s41467-024-53095-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Erratum | Publisher Correction: High salinity shelf water production rates in Terra Nova Bay, Ross Sea from high-resolution salinity observations (Nature Communications, (2024), 15, 1, (373), 10.1038/s41467-023-43880-1) | Correction to: Nature Communications, published online 16 January 2024 The original version of this Article contained an error in Eq. (8j) in the PDF version only, where parts of the equation were not displaying correctly and incorrectly read: (Formula presented.) The correct form of Equation (8j) is: (Formula presented.) This has been corrected in the PDF version of the Article. © 2024, The Author(s). | Miller, Una Kim; Zappa, Christopher J.; Gordon, Arnold L.; Yoon, Seung-Tae; Stevens, Craig; Lee, Won Sang | Lamont-Doherty Earth Observatory of Columbia University, Palisades, NY, United States; Lamont-Doherty Earth Observatory of Columbia University, Palisades, NY, United States; Lamont-Doherty Earth Observatory of Columbia University, Palisades, NY, United States; Kyungpook National University, Daegu, South Korea; National Institute of Water and Atmospheric Research, Wellington, New Zealand, University of Auckland, Auckland, New Zealand; Korea Polar Research Institute, Incheon, South Korea | 56458341400; 6602623584; 7402141938; 37015068400; 7402089802; 55713048700 | ukm2103@columbia.edu; | Nature Communications | NAT COMMUN | N/A | 2041-1723 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0 | 2025-05-07 | 0 | water; article; Ross Sea; salinity; erratum; nonhuman | English | Final | 2024 | 10.1038/s41467-024-45425-6 | 바로가기 | 바로가기 | 바로가기 |
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