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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice | Alzheimer's disease (AD) is characterized by complex, multifactorial neuropathology, suggesting that small molecules targeting multiple neuropathological factors are likely required to successfully impact clinical progression. Acid sphingomyelinase (ASM) activation has been recognized as an important contributor to these neuropathological features in AD, leading to the concept of using ASM inhibitors for the treatment of this disorder. Here we report the identification of KARI 201, a direct ASM inhibitor evaluated for AD treatment. KARI 201 exhibits highly selective inhibition effects on ASM, with excellent pharmacokinetic properties, especially with regard to brain distribution. Unexpectedly, we found another role of KARI 201 as a ghrelin receptor agonist, which also has therapeutic potential for AD treatment. This dual role of KARI 201 in neurons efficiently rescued neuropathological features in AD mice, including amyloid beta deposition, autophagy dysfunction, neuroinflammation, synaptic loss, and decreased hippocampal neurogenesis and synaptic plasticity, leading to an improvement in memory function. Our data highlight the possibility of potential clinical application of KARI 201 as an innovative and multifaceted drug for AD treatment. | Park, Min Hee; Park, Kang Ho; Choi, Byung Jo; Han, Wan Hui; Yoon, Hee Ji; Jung, Hye Yoon; Lee, Jihoon; Song, Im-Sook; Lim, Dong Yu; Choi, Min-Koo; Yang-Ha Lee; Park, Cheol-Min; Wang, Ming; Jo, Jihoon; Kim, Hee-Jin; Kim, Seung Hyun; Schuchman, Edward H.; Jin, Hee Kyung; Bae, Jae-Sung | Kyungpook Natl Univ, KNU Alzheimers Dis Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Physiol, Daegu 41944, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Lab Anim Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr VOICE, BK21 Four Community Based Intelligent Novel Drug, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Dankook Univ, Coll Pharm, Cheonan 31116, South Korea; Ulsan Natl Inst Sci & Technol, Dept Chem, Ulsan 44919, South Korea; Chonnam Natl Univ, BioMed Sci Grad Program, Hwasun 58128, South Korea; Chonnam Natl Univ, Dept Biomed Sci, Med Sch, Gwangju 501757, South Korea; Chonnam Natl Univ, Dept Neurol, Med Sch, Gwangju 501757, South Korea; Hanyang Univ, Dept Neurol, Coll Med, Seoul 04763, South Korea; Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA | Park, Cheol-Min/G-2688-2010; Kim, Young/C-9839-2015; Kim, Young/T-8521-2019; Kim, Heejin/HII-8568-2022; WANG, MING/ABC-2861-2021; KIM, Seung Hyun/T-5133-2017; Bae, Jae-sung/AAM-8663-2021 | 55807755700; 57204158263; 57208899092; 57211890838; 57418719600; 57417768000; 57195979045; 7201564500; 57219057824; 8695781400; 57222387119; 19335557000; 57209397504; 10439910300; 58365187300; 55911799500; 7004364820; 8088145800; 35209510400 | hkjin@knu.ac.kr;jsbae@knu.ac.kr; | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | P NATL ACAD SCI USA | 0027-8424 | 1091-6490 | 119 | 3 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 11.1 | 10.3 | 1.28 | 2025-06-25 | 17 | 18 | Alzheimer's disease; ASM direct inhibitor; GHSR1 alpha agonist; memory improvement; small compound | TRANSGENIC MOUSE MODEL; ACID SPHINGOMYELINASE; GHRELIN; BRAIN; NEUROGENESIS; TRANSLATION; INHIBITORS; INNATE; ROLES; DEATH | Alzheimer's disease; ASM direct inhibitor; GHSR1 alpha agonist; Memory improvement; Small compound | Alzheimer Disease; Animals; Brain; Disease Models, Animal; Hippocampus; Memory; Mice; Neuronal Plasticity; Neurons; Neuropathology; Receptors, Ghrelin; Sphingomyelin Phosphodiesterase; enzyme inhibitor; kari 201; unclassified drug; ASMase, mouse; ghrelin receptor; Ghsr1a protein, mouse; sphingomyelin phosphodiesterase; Alzheimer disease; animal experiment; Article; controlled study; drug distribution; drug effect; memory; mouse; nerve cell plasticity; nervous system development; nervous system inflammation; neuropathology; nonhuman; Alzheimer disease; animal; brain; disease model; genetics; hippocampus; metabolism; nerve cell; neuropathology; pathology; procedures | English | 2022 | 2022-01-18 | 10.1073/pnas.2115082119 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Generation of genome-edited chicken and duck lines by adenovirus-mediated in vivo genome editing | Conventional avian genome editing is mediated by isolation, culture, and genome editing of primordial germ cells (PGCs); screening and propagating the genome-edited PGCs; and transplantation of the PGCs into recipient embryos. The PGC-mediated procedures, however, are technically difficult, and therefore, the conventional method has previously been utilized only in chickens. Here, we generated germline mosaic founder chicken and duck lines without the PGC-mediated procedures by injecting an adenovirus containing the CRISPR-Cas9 system into avian blastoderms. Genome-edited chicken and duck offspring produced from the founders carried different insertion or deletion mutations without mutations in the potential off-target sites. Our data demonstrate successful applications of the adenovirus-mediated method for production of genome-edited chicken and duck lines. | Lee, Joonbum; Kim, Dong-Hwan; Karolak, Madeline C.; Shin, Sangsu; Lee, Kichoon | Ohio State Univ, Dept Anim Sci, Columbus, OH 43210 USA; Kyungpook Natl Univ, Dept Anim Biotechnol, Sangju 37224, South Korea | ; Lee, Kichoon/G-2234-2012; Kim, Donghwan/LRC-0840-2024 | 57194466213; 56621562800; 57385294600; 55490360000; 14123395400 | lee.2626@osu.edu; | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | P NATL ACAD SCI USA | 0027-8424 | 1091-6490 | 119 | 45 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 11.1 | 10.3 | 1.07 | 2025-06-25 | 15 | 16 | adenovirus; CRISPR-Cas9; genome editing; chicken; duck | PRIMORDIAL GERM-CELLS; GENE; KNOCKOUT; VECTOR | adenovirus; chicken; CRISPR-Cas9; duck; genome editing | Adenoviridae; Animals; Chickens; CRISPR-Cas Systems; Ducks; Gene Editing; Germ Cells; Adenoviridae; animal cell; animal experiment; animal tissue; article; blastoderm; chicken; CRISPR-CAS9 system; duck; embryo; gene deletion; gene editing; germ line; in vivo study; nonhuman; primordial germ cell; progeny; Adenoviridae; animal; CRISPR Cas system; duck; genetics; germ cell; procedures | English | 2022 | 2022-11-08 | 10.1073/pnas.2214344119 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | LiNi0.5Mn1.5O4Cathode Microstructure for All-Solid-State Batteries | Solid-state batteries (SSBs) have received attention as a next-generation energy storage technology due to their potential to superior deliver energy density and safety compared to commercial Li-ion batteries. One of the main challenges limiting their practical implementation is the rapid capacity decay caused by the loss of contact between the cathode active material and the solid electrolyte upon cycling. Here, we use the promising high-voltage, low-cost LiNi0.5Mn1.5O4(LNMO) as a model system to demonstrate the importance of the cathode microstructure in SSBs. We design Al2O3-coated LNMO particles with a hollow microstructure aimed at suppressing electrolyte decomposition, minimizing volume change during cycling, and shortening the Li diffusion pathway to achieve maximum cathode utilization. When cycled with a Li6PS5Cl solid electrolyte, we demonstrate a capacity retention above 70% after 100 cycles, with an active material loading of 27 mg cm-2(2.2 mAh cm-2) at a current density of 0.8 mA cm-2 © 2022 American Chemical Society. All rights reserved. | Lee, Hyeon Jeong; Liu, Xiaoxiao; Chart, Yvonne; Tang, Peng; Bae, Jin-Gyu; Narayanan, Sudarshan; Lee, Ji Hoon; Potter, Richard J.; Sun, Yongming; Pasta, Mauro | Department of Materials, University of Oxford, Oxford, OX1 3PH, United Kingdom, The Faraday Institution, Harwell Campus, Quad One, Becquerel Avenue, Didcot, OX11 0RA, United Kingdom, Division of Chemical Engineering and Bioengineering, Kangwon National University, 1 Kangwondaehak-gil, Chuncheon, 24341, South Korea; Department of Materials, University of Oxford, Oxford, OX1 3PH, United Kingdom, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Luoyu Road 1037, Hubei, Wuhan, 430074, China; Department of Materials, University of Oxford, Oxford, OX1 3PH, United Kingdom, The Faraday Institution, Harwell Campus, Quad One, Becquerel Avenue, Didcot, OX11 0RA, United Kingdom; Department of Materials, University of Oxford, Oxford, OX1 3PH, United Kingdom; School of Materials Science and Engineering, Kyungpook National University, Daegu, 41566, South Korea; Department of Materials, University of Oxford, Oxford, OX1 3PH, United Kingdom, The Faraday Institution, Harwell Campus, Quad One, Becquerel Avenue, Didcot, OX11 0RA, United Kingdom; School of Materials Science and Engineering, Kyungpook National University, Daegu, 41566, South Korea; Department of Mechanical, Materials and Aerospace Engineering, University of Liverpool, Brownlow Street, Liverpool, L69 3GH, United Kingdom; Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Luoyu Road 1037, Hubei, Wuhan, 430074, China; Department of Materials, University of Oxford, Oxford, OX1 3PH, United Kingdom, The Faraday Institution, Harwell Campus, Quad One, Becquerel Avenue, Didcot, OX11 0RA, United Kingdom | 56711412600; 56400487000; 57209210397; 57209008862; 57487313300; 57224316999; 55689885200; 7202993130; 56441824000; 24503276200 | mauro.pasta@materials.ox.ac.uk; | Nano Letters | NANO LETT | 1530-6984 | 1530-6992 | 22 | 18 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2022 | 10.8 | 10.3 | 1.66 | 2025-06-25 | 21 | areal capacities; cathode microstructure; high-voltage cathodes; interfaces; solid-state batteries | Alumina; Aluminum oxide; Cathodes; Chlorine compounds; Interface states; Lithium compounds; Lithium-ion batteries; Manganese compounds; Microstructure; Nickel compounds; Solid state devices; Solid-State Batteries; All-solid-state battery; Areal capacity; Capacity decay; Cathode microstructure; Energy density; Energy safety; Energy storage technologies; High-voltage cathodes; LiNi0.5Mn1.5O4; Solid state batteries; Solid electrolytes | English | Final | 2022 | 10.1021/acs.nanolett.2c02426 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Noncanonical PDK4 action alters mitochondrial dynamics to affect the cellular respiratory status | Dynamic regulation of mitochondrial morphology provides cells with the flexibility required to adapt and respond to electron transport chain (ETC) toxins and mitochondrial DNA-linked disease mutations, yet the mechanisms underpinning the regulation of mitochondrial dynamics machinery by these stimuli is poorly understood. Here, we show that pyruvate dehydrogenase kinase 4 (PDK4) is genetically required for cells to undergo rapid mitochondrial fragmentation when challenged with ETC toxins. Moreover, PDK4 overexpression was sufficient to promote mitochondrial fission even in the absence of mitochondrial stress. Importantly, we observed that the PDK4-mediated regulation of mitochondrial fission was independent of its canonical function, i.e., inhibitory phosphorylation of the pyruvate dehydrogenase complex (PDC). Phosphoproteomic screen for PDK4 substrates, followed by nonphosphorylatable and phosphomimetic mutations of the PDK4 site revealed cytoplasmic GTPase, Septin 2 (SEPT2), as the key effector molecule that acts as a receptor for DRP1 in the outer mitochondrial membrane to promote mitochondrial fission. Conversely, inhibition of the PDK4-SEPT2 axis could restore the balance in mitochondrial dynamics and reinvigorates cellular respiration in mitochondrial fusion factor, mitofusin 2-deficient cells. Furthermore, PDK4-mediated mitochondrial reshaping limits mitochondrial bioenergetics and supports cancer cell growth. Our results identify the PDK4-SEPT2-DRP1 axis as a regulator of mitochondrial function at the interface between cellular bioenergetics and mitochondrial dynamics. | Thoudam, Themis; Chanda, Dipanjan; Sinam, Ibotombi Singh; Kim, Byung-Gyu; Kim, Mi-Jin; Oh, Chang Joo; Lee, Jung Yi; Kim, Min-Ji; Park, Soo Yeun; Lee, Shin Yup; Jung, Min-Kyo; Mun, Ji Young; Harris, Robert A.; Ishihara, Naotada; Jeon, Jae-Han; Lee, In-Kyu | Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu 41944, South Korea; Kyungpook Natl Univ, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu 41404, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea; Ulsan Natl Inst Sci & Technol UNIST, Inst Basic Sci IBS, Ctr Genom Integr CGI, Dept Biol Sci, Ulsan 44919, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Colorectal Surg, Daegu 41404, South Korea; Korea Brain Res Inst, Neural Circuit Res Grp, Daegu 41068, South Korea; Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA; Osaka Univ, Grad Sch Sci, Dept Biol Sci, Toyonaka, Osaka 5600043, Japan; Kurume Univ, Inst Life Sci, Dept Prot Biochem, Kurume, Fukuoka 8300011, Japan; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea | Lee, In-Kyu/AAR-6374-2021; Chanda, Dipanjan/AAU-3996-2021; Kim, Byung-Gyu/GYD-6151-2022; Mun, Jiyoung/IUN-3520-2023; thoudam, themis/ACM-3919-2022; Kim, Min-Ji/Z-5205-2019 | 57192905626; 16416525900; 57846985600; 55797167500; 56984392800; 14049080600; 57195563161; 57206189095; 40561578300; 49863712700; 55701234000; 8654053900; 58710709100; 7103146594; 36910340400; 36071537600 | jeonjh@knu.ac.kr;leei@knu.ac.kr; | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | P NATL ACAD SCI USA | 0027-8424 | 1091-6490 | 119 | 34 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 11.1 | 10.3 | 2.13 | 2025-06-25 | 28 | 30 | pyruvate dehydrogenase kinase 4; mitochondrial fission; dynamin-related protein 1; septin 2; OCR | PYRUVATE-DEHYDROGENASE KINASE; ACTIVATED PROTEIN-KINASE; FISSION; DRP1; FUSION; RECRUITMENT; AUTOPHAGY; GROWTH; SITES; MID51 | dynamin-related protein 1; mitochondrial fission; OCR; Pyruvate dehydrogenase kinase 4; septin 2 | Dynamins; GTP Phosphohydrolases; Mitochondria; Mitochondrial Dynamics; Protein Kinases; dynamin I; guanosine triphosphatase; mitofusin 2; pyruvate dehydrogenase complex; pyruvate dehydrogenase kinase 4; septin; dynamin; guanosine triphosphatase; protein kinase; pyruvate dehydrogenase kinase 4; Article; bioenergy; cancer growth; cell respiration; clinical article; controlled study; enzyme inhibition; human; human tissue; mitochondrial dynamics; mitochondrial membrane; oxygen consumption rate; phosphoproteomics; protein expression; protein function; respiratory chain; genetics; mitochondrion | English | 2022 | 2022-08-23 | 10.1073/pnas.2120157119 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Tuning Reaction Pathways of Electrochemical Conversion of CO2 by Growing Pd Shells on Ag Nanocubes | Y The electrochemical carbon dioxide reduction reaction (CO2RR) has been studied on Ag, Pd, Ag@Pd1-2L nanocubes using a combination of in situ characterization and density functional theory calculations. By manipulating the deposition and diffusion rates of Pd atoms on Ag nanocubes, Ag@Pd core-shell nanocubes with a shell thickness of 1-2 atomic layers have been successfully synthesized for CO2RR. Pd nanocubes produce CO with high selectivity due to the transformation of Pd to Pd hydride (PdH) during CO2RR. In contrast, PdH formation becomes more difficult in Ag@Pd1-2L core-shell nanocubes, which inhibits CO production from the *HOCO intermediate and thus tunes the reaction pathway toward HCOOH. Ag nanocubes exhibit high selectivity toward H-2, and there is no phase transition during CO2RR. The results demonstrate that the CO2RR reaction pathways can be manipulated through engineering the surface structure of Pd-based catalysts by allowing or preventing the formation of PdH. | Yang, Xuan; Lee, Ji Hoon; Kattel, Shyam; Xu, Bingjun; Chen, Jingguang G. | Columbia Univ, Dept Chem Engn, New York, NY 10027 USA; Univ Delaware, Dept Chem & Biomol Engn, Newark, DE 19716 USA; Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Mat Chem Energy Convers & Storage, Wuhan 430074, Peoples R China; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Florida A&M Univ, Dept Phys, Tallahassee, FL 32307 USA; Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China | Chen, Jingguang/ABX-2827-2022; Kattel, Shyam/AAK-6985-2020; Lee, Ji/AAU-7285-2021; Lee, Ji Hoon/T-4913-2017 | 57113830800; 55689885200; 36497069200; 56205352500; 57201541202 | shyam.kattel@famu.edu;b_xu@pku.edu.cn;jgchen@columbia.edu; | NANO LETTERS | NANO LETT | 1530-6984 | 1530-6992 | 22 | 11 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2022 | 10.8 | 10.3 | 2.52 | 2025-06-25 | 33 | 32 | carbon dioxide reduction reaction; palladium hydride; core-shell structure; strain effect; density functional theory | ELECTROCATALYTIC REDUCTION; ENHANCED ACTIVITY; ELECTROREDUCTION; DURABILITY | carbon dioxide reduction reaction; core-shell structure; density functional theory; palladium hydride; strain effect | Density functional theory; Hydrides; Palladium compounds; Pollution control; Reaction intermediates; Reduction; Shells (structures); Silver; Silver compounds; Surface structure; Ag nanocubes; Carbon dioxide reduction; Carbon dioxide reduction reaction; Core shell structure; Density-functional-theory; Nanocubes; Palladium hydride; Reaction pathways; Reduction reaction; Strain effect; Carbon dioxide | English | 2022 | 2022-06-08 | 10.1021/acs.nanolett.2c01667 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Accuracy of digitally fabricated drilling guide to form screw-access channels in cement-retained implant prostheses: A randomized clinical trial | Statement of problem. Accurate intraoral preparation of screw channels in cement-retained implant prostheses could be a treatment challenge for tilted or badly positioned implants.Purpose. The purpose of this randomized clinical trial was to evaluate screw channel accuracy for retrieving cement-retained implant prostheses by using a digitally fabricated drilling guide.Material and methods. Twenty-four participants requiring removal of cement-retained implant prostheses were recruited and consecutively assigned to 1 of 2 groups. In the first group, drilling guides were fabricated by using an intraoral scan, computer-aided design (CAD), and 3D printing to facilitate screw channel preparation (guide group). In the second group, screw channel preparation was based on panoramic radiographs without a drilling guide (freehand group). Screw channel accuracy was evaluated with a 3D analysis and subsequently compared with the ideal shape of the screw channel for linear deviation at coronal and apical levels, angular deviation, surface loss deviation, and volume loss deviation. The ideal shape of the screw-access channel was based on the O2.2-mm cylinder image marked along the long axis of the implant. The Mann-Whitney U and Kruskal-Wallis tests were used for statistical analyses (a=.05).Results. The drilling guide group showed higher dimensional accuracy than the freehand group for angular deviation (9.45 degrees versus 15.69 degrees; P=.014) and surface loss deviation (7.40 mm versus 9.53 mm; P=.001), especially when the implant was tilted more than 30 degrees. The deviation values of the screw channels were not significantly different according to implant tilt in either group (P>.05).Conclusions. Digitally fabricated drilling guides for intraoral preparation of screw channels in cement-retained implant prostheses can improve accuracy and provide a less-destructive screw channel. (J Prosthet Dent 2022;128:1282.e1-e8) | Bae, Soohyun; Mai, Hang-Nga; Lee, Du-Hyeong | Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu, South Korea; Kyungpook Natl Univ, Inst Translat Res Dent, Daegu, South Korea; Hanoi Univ Business & Technol, Dent Sch, Hanoi, Vietnam; Kyungpook Natl Univ, Inst Translat Res Dent, Sch Dent, Dept Prosthodont, Daegu, South Korea; Kyungpook Natl Univ, Inst Translat Res Dent, Sch Dent, Dept Prosthodont, 2175 Dalgubeoldae Ro, Daegu 41940, South Korea | ; Mai, Hang-Nga/Q-9865-2018 | 57219625904; 56964780900; 35770948000 | deweylee@knu.ac.kr; | JOURNAL OF PROSTHETIC DENTISTRY | J PROSTHET DENT | 0022-3913 | 1097-6841 | 128 | 6 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2022 | 4.6 | 10.4 | 0.4 | 2025-06-25 | 1 | 2 | ABUTMENT SCREW; TEMPLATE; POSITION; SUPERIMPOSITION; RESTORATIONS; LOCATE; COMPLICATIONS; ANGULATION | Bone Screws; Computer-Aided Design; Dental Cements; Dental Implants; Dental Prosthesis, Implant-Supported; Glass Ionomer Cements; Humans; glass ionomer; tooth cement; bone screw; computer aided design; controlled study; human; implant-supported denture; randomized controlled trial; tooth implant | English | 2022 | 2022-12 | 10.1016/j.prosdent.2022.07.015 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Editorial Material | Chairside fabrication of a tooth reduction guide to ensure adequate occlusal clearance | Lee, Ju-Hyoung | Kyungpook Natl Univ, Dept Predoctoral Clin Educ, Sch Dent, Daegu, South Korea; Kyungpook Natl Univ Dent Hosp, Daegu Dent Clin Ctr Disabled, Daegu, South Korea | 53866763700 | jus2u@knu.ac.kr; | JOURNAL OF PROSTHETIC DENTISTRY | J PROSTHET DENT | 0022-3913 | 1097-6841 | 127 | 3 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2022 | 4.6 | 10.4 | 0 | 2025-06-25 | 0 | 0 | Denture Design; Tooth; denture design; tooth | English | 2022 | 2022-03 | 10.1016/j.prosdent.2020.08.048 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Clinical evaluation of the fit of lithium disilicate crowns fabricated with three different CAD-CAM systems | Statement of problem: The fit and performance of prostheses fabricated using various computer-aided design and computer-aided manufacturing (CAD-CAM) systems have been evaluated. However, most studies were conducted in vitro, and relatively few have addressed gingival parameters and prosthesis fit under clinical conditions. Purpose: This clinical study aimed to compare the fit of lithium disilicate crowns produced using 3 CAD-CAM systems and evaluate clinical results up to 6 months after delivery. Material and methods: Forty participants requiring a single crown were recruited. Three monolithic lithium disilicate crowns were fabricated per participant by using 3 different CAD-CAM systems (intraoral scanners, CAD software, and milling machines): CEREC group (CEREC Bluecam, CEREC AC, CEREC MC); EZIS group (EZIS PO, EZIS VR, EZIS HM); and TRIOS group (TRIOS 3, EXO-CAD, ARUM-4X). The fit of the prostheses was assessed via a silicone replica technique, and the most acceptable crown was delivered; 12 were selected from the CEREC group, 16 from the EZIS group, and 12 from the TRIOS group. Follow-up clinical examinations were performed at 1, 3, and 6 months after delivery. The Kruskal-Wallis test with the post hoc Mann-Whitney U test was conducted to analyze significant differences in crown fit and periodontal conditions among the groups (alpha=.05). Results: The marginal gap of the CEREC group was significantly higher than that of the EZIS group, and the occlusal gap of the EZIS group was significantly lower than those of the CEREC and TRIOS groups (P.05). Conclusions: The lithium disilicate crowns of all groups showed clinically acceptable fit. No significant differences were found among the groups in terms of periodontal conditions after 6 months. | Ahn, Jong-Ju; Bae, Eun-Bin; Lee, Jin-Ju; Choi, Jae-Won; Jeon, Young-Chan; Jeong, Chang-Mo; Yun, Mi-Jung; Lee, So-Hyoun; Lee, Kyu-Bok; Huh, Jung-Bo | Pusan Natl Univ, Dept Prosthodont, Inst Translat Dent Sci, Dent Res Inst,Sch Dent,BK21 PLUS Project, Yangsan, South Korea; Pusan Natl Univ, Dept Prosthodont, Dent Res Inst, Inst Translat Dent Sci,Sch Dent, 20 Geumo Ro, Yangsan 50612, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu, South Korea | Choi, Jae-Won/AAA-1453-2022; Bae, Eun-Bin/AAB-4095-2022 | 57204975220; 57190943615; 57195318670; 59890149800; 7201888408; 7102419311; 55351181900; 56104490500; 15925571200; 8424312600 | huhjb@pusan.ac.kr; | JOURNAL OF PROSTHETIC DENTISTRY | J PROSTHET DENT | 0022-3913 | 1097-6841 | 127 | 2 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2022 | 4.6 | 10.4 | 2.17 | 2025-06-25 | 11 | 12 | DIGITAL IMPRESSION TECHNIQUE; MARGINAL FIT; INTERNAL FIT; CONVENTIONAL IMPRESSIONS; CAD/CAM TECHNOLOGY; CERAMIC CROWNS; ADAPTATION; ACCURACY; RESTORATIONS; THICKNESS | Computer-Aided Design; Crowns; Dental Marginal Adaptation; Dental Porcelain; Dental Prosthesis Design; Humans; dental porcelain; lithia disilicate; computer aided design; dental marginal adaptation; human; procedures; prosthesis design; tooth crown | English | 2022 | 2022-02 | 10.1016/j.prosdent.2020.06.031 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Comparison of microstructures and mechanical properties of 3 cobalt-chromium alloys fabricated with soft metal milling technology | Statement of problem. Although several manufacturers market soft metal milling blanks and systems, comprehensive comparative studies of differences in properties across commercially available soft metal milling alloys are lacking. Purpose. The purpose of this in vitro study was to compare the microstructures and mechanical properties of 3 soft metal milling cobalt-chromium (Co-Cr) alloys (Ceramill Sintron, Soft Metal, and Sintermetall). Material and methods. Disk-shaped specimens (for surface characterization and hardness test) and dumbbell-shaped specimens (for tensile test as per International Organization for Standardization (ISO) 22674) were prepared by following each soft metal milling manufacturer's instructions. The crystal structures and microstructures of the 3 alloys were evaluated with optical microscopy, X-ray diffractometry (XRD), and scanning electron microscopy with electron backscattered diffraction (EBSD). The mechanical properties were investigated with a tensile test and Vickers hardness test (n=6). The results of the mechanical (tensile and hardness) tests were analyzed with 1-way ANOVA and the post hoc Tukey multiple comparison test (alpha=.05). Results. The Sintermetall specimen showed a finer microstructure and more porosity than the other 2 alloys. The XRD and EBSD analyses showed that the g (face-centered cubic, fcc) matrix phase was predominant in the Ceramill Sintron alloy and the e (hexagonal close-packed, hcp) matrix phase was predominant in the Soft Metal alloy. The Sintermetall alloy showed a slightly higher amount of e phase than g phase, with more chromium carbide formation than the other 2 alloys. The Ceramill Sintron alloy showed a significantly higher tensile strength than the other 2 alloys (P<.05), but a significantly lower 2% offset yield strength than the other 2 alloys (P<.05). The highest elongation was found in the Ceramill Sintron alloy, followed by the Sintermetall and Soft Metal alloys. The elastic modulus was the highest in the Sintermetall alloy, followed by the Soft Metal and Ceramill Sintron alloys. No significant differences in Vickers hardness values were detected among the 3 alloys (P=.263). Conclusions. The different commercially available soft metal milling blanks and systems produced dissimilar alloys in terms of crystal structures and microstructures and, as a result, different mechanical properties. | Hong, Min-Ho; Lee, Du-Hyeong; Hanawa, Takao; Kwon, Tae-Yub | Catholic Univ Pusan, Coll Hlth Sci, Dept Dent Lab Sci, Busan, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu, South Korea; Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Dept Metall Mat, Tokyo, Japan; Kyungpook Natl Univ, Sch Dent, Dept Dent Biomat, 2177 Dalgubeol Daero, Daegu 41940, South Korea | 57192705343; 35770948000; 55532801000; 7202206084 | tykwon@knu.ac.kr; | JOURNAL OF PROSTHETIC DENTISTRY | J PROSTHET DENT | 0022-3913 | 1097-6841 | 127 | 3 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2022 | 4.6 | 10.4 | 2.17 | 2025-06-25 | 8 | 12 | FIXED DENTAL PROSTHESES; CR-MO ALLOYS; MARGINAL FIT; AS-CAST; BEHAVIOR | Alloys; Chromium Alloys; Materials Testing; Metal Ceramic Alloys; Surface Properties; Technology; Tensile Strength; alloy; chromium derivative; metal ceramic alloy; chemistry; materials testing; surface property; technology; tensile strength | English | 2022 | 2022-03 | 10.1016/j.prosdent.2020.07.037 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Conducting polymer based visible light photocatalytic composites for pollutant removal: Progress and prospects | Conducting polymers (CPs) have been proved to be instrumental in enhancing photocatalytic efficacy owing to their unique physicochemical properties and energy levels. In this regard, titanium dioxide (TiO2) has been investigated in transdisciplinary research areas (like catalysis, energy technologies, health, and environment) due to its desirable characteristics. In the process of developing advanced photocatalysts, novel inorganic-organic heterojunction design based materials have been explored and developed in contrast to conventional, inorganic-inorganic type semiconducting photocatalysts (SCPs). In this context, hybrid/composite SCPs comprising CPs and TiO2, have received significant attention for enhancing photocatalytic efficacy in terms of activity as well as visible light activation. The synergistic contribution from CPs (here we focus only on polyaniline (PANI) and polypyrrole (PPy)) and TiO2 have been proved to enhance light-absorption capability in the visible region, photogenerated extraction, and higher stability. Importantly, the published literature (before 2015) on the photocatalysis of TiO2-CP composites mainly discusses in terms of the sensitizing aspects of CP for TiO2. However, there is a critical need to review the literature (beyond 2015) to explore the state of art progress concerning the mechanism of photocatalytic performances as phenomenal parallel developments and knowledge gaps have been addressed on new kinds of heterojunction formation (like S-Scheme over traditional ones), band tuning and interfacial contact effects between two SCPs. In particular, this topical review aims to capture and highlight the current advancements (2016-2021) in relevance to the visible light photocatalytic performance of CP-TiO2 functional composites, which include nanostructures and multi-components. The predominantly available literature over the last five years on the application of CPs-TiO2 functional composites for monitoring or removal of pollutants under visible light activation is reviewed giving importance to revealing the role of CP in concurrent enhancement in both visible light activation and photocatalytic performances. Finally, we elaborate on the challenges and future outlook for advanced research and development in this area. (c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Saianand, Gopalan; Gopalan, Anantha-Iyengar; Wanga, Liang; Venkatramanan, K.; Roy, Vellaisamy A. L.; Sonar, Prashant; Lee, Dong-Eun; Naidu, Ravi | Univ Newcastle, Coll Engn Sci & Environm, Global Ctr Environm Remediat GCER, Callaghan, NSW 2308, Australia; Cooperat Res Ctr Contaminat Assessment & Remediat, CRC CARE, Callaghan, NSW 2308, Australia; Kyungpook Natl Univ, Intelligent Construct Automat Ctr, Daegu 41566, South Korea; SCSVMV Deemed Univ, Dept Phys, Kanchipuram 631561, Tamil Nadu, India; Univ Glasgow, James Watt Sch Engn, Glasgow G12 8QQ, Scotland; Queensland Univ Technol QUT, Sch Chem & Phys, Ctr Mat Sci, 2 George St, Brisbane, Qld 4001, Australia; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, 80 Daehakro, Daegu 41566, South Korea | ; VELLAISAMY, Arul Lenus Roy/NDY-9741-2025; Sonar, Prashant/E-8827-2011; kannan, venkatramanan/N-4628-2016; Naidu, Ravi/F-5927-2012; Gopalan, Saianand/J-6000-2019 | 38362265400; 57191999779; 55954305500; 57218952492; 7005870324; 8523056200; 56605563300; 7102091779 | SaiAnand.Gopalan@newcastle.edu.au;Dolee@knu.ac.kr;Ravi.Naidu@newcastle.edu.au; | ENVIRONMENTAL TECHNOLOGY & INNOVATION | ENVIRON TECHNOL INNO | 2352-1864 | 28 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES | 2022 | 7.1 | 10.4 | 1.39 | 2025-06-25 | 35 | 43 | Conducting polymers; Inorganic semiconductors; Visible light mediation; Photocatalysis | TITANIUM-DIOXIDE; MODIFIED TIO2; FACILE SYNTHESIS; HOLLOW PHOTOCATALYST; ORGANIC POLLUTANTS; ZNO NANOPARTICLES; EFFICIENT REMOVAL; METHYLENE-BLUE; OXYGEN VACANCY; BISPHENOL-A | Conducting polymers; Inorganic semiconductors; Photocatalysis; Visible light mediation | Chemical activation; Heterojunctions; Light; Light absorption; Photocatalytic activity; Physicochemical properties; Pollution; Polyaniline; Polypyrroles; Functional composites; Inorganic semiconductors; Inorganics; Photo-catalytic; Photocatalytic performance; Pollutants removal; Polymer based; Visible light; Visible light activations; Visible light mediation; Titanium dioxide | English | 2022 | 2022-11 | 10.1016/j.eti.2022.102698 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Editorial Material | Design concept to facilitate the positioning of a custom abutment on an implant | Lee, Ju-Hyoung | Kyungpook Natl Univ, Sch Dent, Dept Predoctoral Clin Educ, Daegu, South Korea; Kyungpook Natl Univ Dent Hosp, Daegu Dent Clin Ctr Disabled, Daegu, South Korea | 53866763700 | jus2u@knu.ac.kr; | JOURNAL OF PROSTHETIC DENTISTRY | J PROSTHET DENT | 0022-3913 | 1097-6841 | 127 | 3 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2022 | 4.6 | 10.4 | 0.2 | 2025-06-25 | 1 | 1 | Dental Abutments; Dental Implant-Abutment Design; Dental Implants; dental abutment; tooth implant | English | 2022 | 2022-03 | 10.1016/j.prosdent.2020.09.044 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Digital approach to fabricating a retrofitted abutment for reuse of an existing implant-supported fixed partial denture after the failure of an implant | The failure of an implant that supports an implant-supported fixed partial denture (ISFPD) may result in a failure of the prosthesis. Although fabricating a new ISFPD after replacing the implant is ideal, patients may hope to reuse the existing ISFPD because of financial constraints. A technique for rescuing a 6-unit metal-ceramic ISFPD with computer-aided design and computer aided manufacturing (CAD-CAM) technology is described. | Lee, Ju-Hyoung | Kyungpook Natl Univ, Sch Dent, Dept Predoctoral Clin Educ, Daegu, South Korea; Kyungpook Natl Univ Dent Hosp, Daegu Dent Clin Ctr Disabled, Daegu, South Korea | 53866763700 | jus2u@knu.ac.kr; | JOURNAL OF PROSTHETIC DENTISTRY | J PROSTHET DENT | 0022-3913 | 1097-6841 | 127 | 2 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2022 | 4.6 | 10.4 | 0.2 | 2025-06-25 | 1 | 1 | TITANIUM ABUTMENTS; SOFT-TISSUE; ACCURACY; CROWN; TECHNOLOGY; SURVIVAL; VERIFY | Ceramics; Computer-Aided Design; Dental Implants; Dental Prosthesis, Implant-Supported; Denture, Partial, Fixed; Humans; ceramics; computer aided design; fixed partial denture; human; implant-supported denture; tooth implant | English | 2022 | 2022-02 | 10.1016/j.prosdent.2020.08.027 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Asymptotic homology of graph braid groups | We give explicit formulas for the asymptotic Betti numbers of the unordered configuration spaces of an arbitrary finite graph over an arbitrary field. © The Authors. | An, Byung Hee; Drummond-Cole, Gabriel C.; Knudsen, Ben | Department of Mathematics Education, Teachers College, Kyungpook National University, Daegu, South Korea; Center for Geometry and Physics, Institute for Basic Science (IBS) Pohang, South Korea; Mathematics Department, Northeastern University, Boston, MA, United States | 36599927400; 55260653700; 57195227248 | Geometry and Topology | GEOM TOPOL | 1465-3060 | 1364-0380 | 26 | 4 | SCIE | MATHEMATICS | 2022 | 2 | 10.5 | 0 | 2025-06-25 | 0 | English | Final | 2022 | 10.2140/gt.2022.26.1745 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Associations between game use and mental health in early adulthood: A nationwide study in Korea | Background: : The number of digital game users is increasing, and so is attention to digital gaming's effects on mental health. We aimed to reveal if risky (game addiction) and usual game use (non-risky) are associated with mental health in early adulthood. Methods: : Using data from the nationwide cross-sectional Korean Epidemic Catchment Area study for psychiatric disorders, 415 participants aged 18-30 years were divided into "non-game," "usual game," and "risky game" user groups based on the previous month's game use and cut-off value of game overuse screening questionnaire. Multiple linear and logistic regressions revealed the association between game use groups, perceived mental health, and lifetime prevalence of clinical mental disorders including suicidal ideation. Results: : Among the 415 participants, 167 were non-game users, 175, usual game users, and 73, risky game users. Risky game users self-reported decreased satisfaction and happiness, and a significantly higher lifetime prevalence of major depressive disorder, alcohol dependence, and suicidal ideation. Usual game users were significantly associated with higher lifetime prevalence of alcohol dependence and suicidal ideation. Self-reported happiness partially mediated between game use and lifetime suicidal ideation in risky, but not usual game users. Limitations: : This study is a cross-sectional observational study which was not possible to define the temporal relationship. Conclusions: : Both risky and usual game use are associated with mental health problems in early adulthood, indicating the need for careful mental health screening on not only risky game users but also usual game users. | Byeon, Gihwan; Park, Jee Eun; Jeon, Hong Jin; Seong, Su Jeong; Lee, Dong-Woo; Cho, Seong-Jin; Chang, Sung Man; Kim, Byung-Soo; Hahm, Bong-Jin; Hong, Jin Pyo; Park, Jong-Ik | Kangwon Natl Univ Hosp, Dept Neuropsychiat, 156 Baengnyeong Ro, Chuncheon Si 24289, Gangwon Do, South Korea; Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul, South Korea; Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Dept Psychiat, Seoul, South Korea; Samsung Med Ctr, Dept Psychiat, Seoul, South Korea; Kangdong Sacred Heart Hosp, Dept Psychiat, Seoul, South Korea; Inje Univ, Dept Psychiat, Coll Med, Seoul, South Korea; Gachon Med Sch, Dept Psychiat, Incheon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, D, Daegu, South Korea; Kangwon Natl Univ, Dept Psychiat, Coll Med, Chunchon, South Korea | ; Hahm, Bong-Jin/J-5714-2012; Kim, Byung-Soo/H-4047-2013; Lee, Dong/H-2427-2012 | 57218598213; 56119414400; 35195917400; 55079714000; 57212667898; 57199760447; 23092756400; 57323398100; 6601908426; 55729426400; 15036290300 | lugar@kangwon.ac.kr; | JOURNAL OF AFFECTIVE DISORDERS | J AFFECT DISORDERS | 0165-0327 | 1573-2517 | 297 | SCIE;SSCI | CLINICAL NEUROLOGY;PSYCHIATRY | 2022 | 6.6 | 10.6 | 0.87 | 2025-06-25 | 8 | 8 | Game addiction; Mental health; Early adulthood | INTERNET GAMING DISORDER; VIDEO-GAME; INTERNATIONAL CONSENSUS; PSYCHIATRIC-DISORDERS; GENDER-DIFFERENCES; ADDICTION; PREVALENCE; SUICIDE; VIOLENT; JAPAN | Early adulthood; Game addiction; Mental health | Adult; Cross-Sectional Studies; Depressive Disorder, Major; Humans; Mental Health; Republic of Korea; Risk Factors; Suicidal Ideation; adult; adulthood; alcoholism; Article; catchment area; controlled study; cross-sectional study; female; game addiction; human; lifetime prevalence; logistic regression analysis; major clinical study; major depression; male; mental disease; mental health; observational study; suicidal ideation; epidemiology; major depression; risk factor; South Korea | English | 2022 | 2022-01-15 | 10.1016/j.jad.2021.10.064 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | Combined treatment with interleukin-4 receptor-targeted cytotoxic peptide and PD-L1-blocking peptide efficiently induces immunogenic cell death of tumor cells and activates T-cell activity | Park, Nawon; Lee, Byungheon; Lee, Hyunsu | Kyungpook Natl Univ, Sch Med, Daegu, South Korea | CANCER RESEARCH | CANCER RES | 0008-5472 | 1538-7445 | 82 | 12 | SCIE | ONCOLOGY | 2022 | 11.2 | 10.6 | 0 | English | 2022 | 2022-06-15 | 바로가기 | 바로가기 |
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