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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Evolution and Spread of Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Wild Birds, South Korea, 2022-2023 | During October 2022-March 2023, highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b virus caused outbreaks in South Korea, including 174 cases in wild birds. To understand the origin and role of wild birds in the evolution and spread of HPAI viruses, we sequenced 113 HPAI isolates from wild birds and performed phylogenetic analysis. We identified 16 different genotypes, indicating extensive genetic reassortment with viruses in wild birds. Phylodynamic analysis showed that the viruses were most likely introduced to the southern Gyeonggi-do/northern Chungcheongnamdo area through whooper swans (Cygnus cygnus) and spread southward. Cross-species transmission occurred between various wild bird species, including waterfowl and raptors, resulting in the persistence of HPAI in wild bird populations and further geographic spread as these birds migrated throughout South Korea. Enhanced genomic surveillance was an integral part of the HPAI outbreak response, aiding in timely understanding of the origin, evolution, and spread of the virus. | Seo, Ye-Ram; Cho, Andrew Y.; Si, Young-Jae; Lee, Song-I; Kim, Dong-Ju; Jeong, Hyesung; Kwon, Jung-Hoon; Song, Chang-Seon; Lee, Dong-Hun | Konkuk Univ, Coll Vet Med, Seoul, South Korea; Konkuk Univ, Seoul, South Korea; Natl Inst Wildlife Dis Control & Prevent, Gwangju, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea | ; Song, Chang-Seon/D-7282-2011; Lee, Sang-hun/JWA-2671-2024 | 58147230400; 57211355010; 56596215900; 57220668830; 58850798400; 57213935791; 55559800200; 55555239800; 57776535400 | donghunlee@konkuk.ac.kr; | EMERGING INFECTIOUS DISEASES | EMERG INFECT DIS | 1080-6040 | 1080-6059 | 30 | 2 | SCIE | IMMUNOLOGY;INFECTIOUS DISEASES | 2024 | 6.6 | 6.2 | 7.89 | 2025-05-07 | 15 | 15 | EMERGENCE; SURVEILLANCE; MIGRATION | Animals; Animals, Wild; Birds; Ducks; Humans; Influenza A Virus, H5N1 Subtype; Influenza in Birds; Influenza, Human; Phylogeny; Republic of Korea; hemagglutinin; Article; avian influenza (H5N1); bird; controlled study; disease transmission; gene sequence; genetic reassortment; genetic variation; genotype; geographic distribution; highly pathogenic avian influenza; human; Influenza A virus (H5N1); Korea; nonhuman; phylogeny; phylogeography; raptor (bird); South Korea; virus transmission; waterfowl; zoonotic transmission; animal; avian influenza; duck; genetics; influenza; Influenza A virus (H5N1); wild animal | English | 2024 | 2024-02 | 10.3201/eid3002.231274 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Highly Pathogenic Avian Influenza A(H5N1) Virus Infection in Cats, South Korea, 2023 | In July 2023, cases of highly pathogenic avian influenza (HPAI) were reported at 2 shelters for stray cats in Seoul, South Korea. The cause of infection was suspected to be improperly sterilized raw food made from domestic duck meat, which was manufactured in South Korea. All viruses isolated from cats at the shelters and from the raw food belonged to HPAI A(H5N1) clade 2.3.4.4b. The gene constellation of all viruses was most similar to that of viruses isolated in Korea in November 2022. Of note, the viruses isolated from infected cats harbored mutations E627K or D701N in polymerase basic 2, which are indicative of adaptation to mammals. Postmortem examination revealed systemic pathologic lesions and the presence of widespread virus in different tissues. Thus, consumption of raw duck meat contaminated with HPAI virus likely caused systemic symptoms and death in cats, indicating the introduction of mammal-adapted mutations of the virus. © 2024 Centers for Disease Control and Prevention (CDC). All rights reserved. | Kang, Yong-Myung; Heo, Gyeong-Beom; An, Se-Hee; Lee, Hyunho; Park, Eunhye; Cha, Ra Mi; Jang, Yun Yueng; Sagong, Mingeun; Kim, Ah-Young; Kim, Jongho; Lee, Eun-Kyoung; Kim, Seong Hee; Lee, Kyungki; Ku, Bokkyung; Lee, Youn-Jeong; Lee, Kyunghyun; Lee, Kwang-Nyeong | Animal and Plant Quarantine Agency, Gimcheon-si, South Korea, Seoul National University, Seoul, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea, Seoul Metropolitan Government Research Institute of Public Health and Environment, Gwacheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea, Seoul Metropolitan Government Research Institute of Public Health and Environment, Gwacheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea; Animal and Plant Quarantine Agency, Gimcheon-si, South Korea, Kyungpook National University, Daegu, South Korea | 57211580286; 57189089623; 57195539685; 59438747600; 59440712600; 57194199657; 57203534125; 57205461615; 7402063210; 57202162365; 25938359000; 34769762800; 38163138800; 9745131200; 55533095600; 35183367100; 35285884300 | leekwn@korea.kr;mylovehyun@korea.kr; | Emerging Infectious Diseases | EMERG INFECT DIS | 1080-6040 | 1080-6059 | 30 | 12 | SCIE | IMMUNOLOGY;INFECTIOUS DISEASES | 2024 | 6.6 | 6.2 | 0 | 2025-05-07 | 4 | Animals; Cat Diseases; Cats; Ducks; Influenza A Virus, H5N1 Subtype; Influenza in Birds; Mutation; Orthomyxoviridae Infections; Phylogeny; Republic of Korea; hemagglutinin; animal experiment; Article; avian influenza (H5N1); avian influenza virus; bloody diarrhea; Burkholderia mallei; Candida tropicalis; cat; dog; genetic analysis; highly pathogenic avian influenza; highly pathogenic avian influenza virus; histopathology; immunohistochemistry; influenza; interstitial pneumonia; microvascular thrombosis; nonhuman; raw food; reverse transcription polymerase chain reaction; South Korea; virus infection; waterfowl; animal; avian influenza; cat disease; duck; epidemiology; genetics; Influenza A virus (H5N1); isolation and purification; mutation; orthomyxovirus infection; pathogenicity; phylogeny; veterinary medicine; virology | English | Final | 2024 | 10.3201/eid3012.240154 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | Conference paper | In-situ Observation of Formation Mechanism of Infinite-layer Iron Oxide | [No abstract available] | Xing, Yaolong; Kim, Inhwan; Kang, Kyeong Tae; Choi, Woo Seok; Lee, Jaekwang; Oh, Sang Ho | Department of Energy Engineering, Institute for Energy Materials and Devices, Korea Institute of Energy Technology (KENTECH), Naju, South Korea; Department of Physics, Pusan National University, Busan, South Korea; Department of Physics, Kyungpook National University, Daegu, South Korea; Department of Physics, Sungkyunkwan University, Suwon, South Korea; Department of Physics, Pusan National University, Busan, South Korea; Department of Energy Engineering, Institute for Energy Materials and Devices, Korea Institute of Energy Technology (KENTECH), Naju, South Korea | 57220044509; 57226310158; 56002123900; 14031133800; 55888626200; 57558169000 | shoh@kentech.ac.kr; | Microscopy and Microanalysis | MICROSC MICROANAL | 1431-9276 | 1435-8115 | 30 | 2024 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;MICROSCOPY | 2024 | 3 | 6.2 | 0 | 2025-05-07 | 0 | English | Final | 2024 | 10.1093/mam/ozae044.800 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Information and Communications Technology-Based MonitoringService for Tailored Chronic Disease Management in PrimaryCare:Cost-Effectiveness Analysis Based on ICT-CM Trial Results | Background: Information and communications technology-based tailored management (TM) intervention is a novel automatic system in which a smartphone app for the management of patients with hypertension and diabetes, the provider web, and Bluetooth devices are linked. However, little evidence exists regarding the cost-effectiveness of the interventions using mobile apps. Objective: This study aimed to assess the cost-effectiveness of TM intervention for adult patients with hypertension or diabetes in primary care compared with usual care (UC). Methods: Cost-effectiveness analysis using a Markov model was conducted from the Korean health care system perspective. Based on 6-month outcome data from an information and communications technology-based tailored chronic disease management (ICT-CM) trial, effectiveness over a lifetime beyond the trial periods was extrapolated using a cardiovascular disease risk prediction model. Costs were estimated using ICT-CM trial data and national health insurance claims data. Health utility weights were obtained from the Korea National Health and Nutrition Examination Survey. Results: In the base-case analysis, compared with UC, TM was more costly (US $23,157 for TM vs US $22,391 for UC) and more effective (12.006 quality-adjusted life-years [QALYs] for TM vs 11.868 QALYs for UC). The incremental cost-effectiveness ratio was US $5556 per QALY gained. Probabilistic sensitivity analysis showed that the probability of TM being cost-effective compared with UC was approximately 97% at an incremental cost-effectiveness ratio threshold of US $26,515 (KRW 35 million) per QALY gained. Conclusions: Compared with UC, TM intervention is a cost-effective option for patients with hypertension or diabetes in primary care settings. The study results can assist policy makers in making evidence-based decisions when implementing accessible chronic disease management services. | Oh, Sung-Hee; Kang, Jae-Heon; Kwon, Jin-Won | Kyungpook Natl Univ, Coll Pharm, Brain Korea 21 Four Community Based Intelligent No, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, 80 Daehak Ro, Daegu 41566, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Coll Med, Dept Family Med, Seoul, South Korea | Kim, Il Young/LLK-4732-2024 | 57188550994; 57217443426; 16202951700 | jwkwon@knu.ac.kr; | JOURNAL OF MEDICAL INTERNET RESEARCH | J MED INTERNET RES | 1438-8871 | 26 | SCIE | HEALTH CARE SCIENCES & SERVICES;MEDICAL INFORMATICS | 2024 | 6 | 6.2 | 0 | 2025-05-07 | 0 | 0 | mHealth; mobile health; smartphone application; cost-effectiveness analysis; hypertension; diabetes mellitus; primary care;artificial intelligence; applications digital health; mobile phone | UKPDS RISK ENGINE; CARDIOVASCULAR RISK; ECONOMIC-EVALUATION; SELF-MANAGEMENT; HEALTH; PROFILE; STROKE | applications digital health; artificial intelligence; cost-effectiveness analysis; diabetes mellitus; hypertension; mHealth; mobile health; mobile phone; primary care; smartphone application | Adult; Aged; Chronic Disease; Cost-Benefit Analysis; Cost-Effectiveness Analysis; Diabetes Mellitus; Disease Management; Female; Humans; Hypertension; Male; Markov Chains; Middle Aged; Mobile Applications; Primary Health Care; Quality-Adjusted Life Years; Republic of Korea; antihypertensive agent; cholesterol; hemoglobin A1c; high density lipoprotein cholesterol; adult; aged; antihypertensive therapy; Article; cardiovascular disease; cardiovascular risk; cardiovascular risk factor; chronic disease; claims based algorithm; clinical outcome; cohort analysis; communication technology; comparative study; controlled study; cost effectiveness analysis; current smoker; diabetes mellitus; diabetic patient; diastolic blood pressure; female; Framingham risk score; gender; health care cost; health care system; human; hypertension; hypertensive patient; intervention study; major clinical study; male; medical informatics; middle aged; multicenter study (topic); national health insurance; patient care; predictive model; primary medical care; quality adjusted life year; quality of life; randomized controlled trial (topic); risk model; sensitivity analysis; South Korea; systolic blood pressure; tailored management; total cholesterol level; very elderly; chronic disease; cost benefit analysis; cost effectiveness analysis; diabetes mellitus; disease management; economics; hypertension; Markov chain; mobile application; primary health care; procedures; therapy | English | 2024 | 2024-10-11 | 10.2196/51239 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Sampled-Data-Based Iterative Cost-Learning Model Predictive Control for T-S Fuzzy Systems | In this article, an iterative cost-learning model predictive control (ICLMPC) is proposed for nonlinear networked control systems (NCSs) in the presence of aperiodic sampling. The proposed ICLMPC is useful not only to guarantee asymptotic stability of the closed-loop system with aperiodic sampling but also to improve control performance in the case of performing an iterative task. In the proposed method, the nonlinear system of NCSs is mathematically represented as an aperiodic sampled-data Takagi-Sugeno (T-S) fuzzy system. Based on this representation, the ICLMPC design is formulated in terms of a finite-horizon optimal control problem in which a new terminal cost function is considered. The terminal cost function is constructed by a Lyapunov function with a looped-functional and an iteratively minimized function (IMF). From the Lyapunov function with the looped-functional, it is possible to guarantee that the ICLMPC asymptotically stabilizes the aperiodic sampled-data T-S fuzzy system. To obtain an iteratively improved control performance, the IMF takes the minimized value among the integrals of the collected data at each iteration. The validity and effectiveness of the proposed method are illustrated by two practical examples in the simulation section. | Han, Seungyong; Park, Sejun; Lee, Sangmoon | Korea Atom Energy Res Inst, Dept Instrumentat & Control, Daejeon 34057, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | Park, Sejun/KUD-3460-2024; Lee, Sangmoon/C-4502-2018; Han, Seungyong/AAN-8632-2021 | 57200991395; 58097901300; 59510733500 | seungyong@kaeri.re.kr;sjpark@knu.ac.kr;moony@knu.ac.kr; | IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS | IEEE T SYST MAN CY-S | 2168-2216 | 2168-2232 | 54 | 8 | SCIE | AUTOMATION & CONTROL SYSTEMS;COMPUTER SCIENCE, CYBERNETICS | 2024 | 8.7 | 6.2 | 0.74 | 2025-04-16 | 4 | 4 | Stability analysis; Iterative methods; Task analysis; Costs; Predictive models; Optimal control; Lyapunov methods; Iterative cost learning; model predictive control (MPC); sampled-data control systems; Takagi-Sugeno (T-S) fuzzy systems | Iterative cost learning; model predictive control (MPC); sampled-data control systems; Takagi–Sugeno (T–S) fuzzy systems | Asymptotic stability; Closed loop systems; Cost benefit analysis; Cost functions; Fuzzy systems; Learning systems; Lyapunov functions; Lyapunov methods; Model predictive control; Networked control systems; Optimal control systems; Sampled data control systems; Cost learning; Iterative cost learning; Lyapunov's methods; Model predictive control; Model-predictive control; Optimal controls; Predictive models; Sampled-data control system; Stability analyze; Takagi Sugeno fuzzy systems; Task analysis; Iterative methods | English | 2024 | 2024-08 | 10.1109/tsmc.2024.3388853 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Tho2-mediated escort of Nrd1 regulates the expression of aging-related genes | The relationship between aging and RNA biogenesis and trafficking is attracting growing interest, yet the precise mechanisms are unknown. The THO complex is crucial for mRNA cotranscriptional maturation and export. Herein, we report that the THO complex is closely linked to the regulation of lifespan. Deficiencies in Hpr1 and Tho2, components of the THO complex, reduced replicative lifespan (RLS) and are linked to a novel Sir2-independent RLS control pathway. Although transcript sequestration in hpr1 Delta or tho2 Delta mutants was countered by exosome component Rrp6, loss of this failed to mitigate RLS defects in hpr1 Delta. However, RLS impairment in hpr1 Delta or tho2 Delta was counteracted by the additional expression of Nrd1-specific mutants that interacted with Rrp6. This effect relied on the interaction of Nrd1, a transcriptional regulator of aging-related genes, including ribosome biogenesis or RNA metabolism genes, with RNA polymerase II. Nrd1 overexpression reduced RLS in a Tho2-dependent pathway. Intriguingly, Tho2 deletion mirrored Nrd1 overexpression effects by inducing arbitrary Nrd1 chromatin binding. Furthermore, our genome-wide ChIP-seq analysis revealed an increase in the recruitment of Nrd1 to translation-associated genes, known to be related to aging, upon Tho2 loss. Taken together, these findings underscore the importance of Tho2-mediated Nrd1 escorting in the regulation of lifespan pathway through transcriptional regulation of aging-related genes. Loss of Tho2 leads to an increase in Nrd1 recruitment to translation-associated genes, known as aging-related genes, thereby resulting in decreased expression of these genes. RLS impairment in tho2 Delta is counteracted by the disturbance of WT Nrd1 function due to the presence of Nrd1 mutants.image | Liu, Yan; Park, Jeong-Min; Lim, Suji; Duan, Ruxin; Lee, Do Yoon; Choi, Dahee; Choi, Dong Kyu; Rhie, Byung-Ho; Cho, Soo Young; Ryu, Hong-Yeoul; Ahn, Seong Hoon | Hanyang Univ, Coll Sci & Convergence Technol, Dept Mol & Life Sci, Ansan 15588, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Coll Nat Sci,KNU LAMP Res Ctr,KNU Inst Basic Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, Coll Nat Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu, South Korea | Choi, dongKyu/LKL-2959-2024 | 56940563800; 59136146100; 57222811485; 55901870500; 59136005700; 59135735300; 57215816624; 55890105100; 36482483000; 55889917800; 7401989611 | sooycho@hanyang.ac.kr;rhr4757@knu.ac.kr;hoon320@hanyang.ac.kr; | AGING CELL | AGING CELL | 1474-9718 | 1474-9726 | 23 | 8 | SCIE | CELL BIOLOGY;GERIATRICS & GERONTOLOGY | 2024 | 7.1 | 6.2 | 1.35 | 2025-05-07 | 3 | 3 | aging-related genes; Nrd1; replicative lifespan; THO complex; transcription | MESSENGER-RNA EXPORT; LIFE-SPAN; THO COMPLEX; SACCHAROMYCES-CEREVISIAE; HISTONE SUMOYLATION; QUALITY-CONTROL; YEAST NRD1; TRANSCRIPTION; TERMINATION; LONGEVITY | aging-related genes; Nrd1; replicative lifespan; THO complex; transcription | arginine; glutamine; heparanase; heparanase 1; lithium acetate; messenger RNA; nuclear RNA; PTB associated splicing factor; RNA polymerase II; serine; thorium dioxide; transcription factor; transcription factor nrd1; unclassified drug; 3' untranslated region; Article; binding site; carbohydrate metabolism; cell aging; chromatin; chromatin immunoprecipitation; chromatin immunoprecipitation sequencing; cluster analysis; colony forming unit; controlled study; daughter cell; differential gene expression; exosome; gene cluster; gene control; gene deletion; gene expression profiling; gene expression regulation; gene loss; gene ontology; gene overexpression; gene targeting; genetic association; genetic background; genome-wide association study; k means clustering; lifespan; mutant; nonhuman; nucleocytoplasmic transport; organelle biogenesis; paired end sequencing; PAR-CLIP; plasmid; promoter region; protein phosphorylation; replicative lifespan; ribosome; RNA degradation; RNA metabolism; RNA processing; RNA recognition motif; temperature sensitive mutant; transcription initiation; transcription initiation site; transcription regulation; transcription termination; yeast | English | 2024 | 2024-08 | 10.1111/acel.14203 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Wearable chemical gas sensors with color changeable functional dyes for detection of organophosphorus nerve agents | Wearable military chemical gas sensors were realized using 19 types of color-changeable functional dyes with great aggregative characteristics, and the optimal wearable sensor with the best detection performance was selected. The wearable sensor was designed to demonstrate color change, which exhibited high sensitivity to low concentrations of chemical warfare agent vapors at room temperature. The dyes were applied to textile substrates (cotton fabrics) of the wearable chemical gas sensors, and their sensing properties, performance, and mechanisms were examined for an organophosphorus simulant of nerve agents, dimethyl methyl phosphonate (DMMP). A color difference of almost 5 was obtained at 3 ppm within 10 min, and the spectrum exhibited hypsochromic and hyperchromic shifts. The sensing mechanism was found to depend on solvatochromism, aggregative characteristics of the dye molecules, and the adsorption amount of DMMP vapor on textile substrates. In addition, the reusability of the wearable sensor was tested for ten repeat cycles. | Lee, Junheon; Kim, Taekyeong | Kyungpook Natl Univ, Coll Engn, Dept Text Syst Engn, Daegu, South Korea | 57195904688; 24587275700 | taekyeong@knu.ac.kr; | CELLULOSE | CELLULOSE | 0969-0239 | 1572-882X | 31 | 6 | SCIE | MATERIALS SCIENCE, PAPER & WOOD;MATERIALS SCIENCE, TEXTILES;POLYMER SCIENCE | 2024 | 4.8 | 6.2 | 0.38 | 2025-05-07 | 1 | 1 | Organophosphorus nerve agent; Wearable sensor; Vapochromism; Aggregation; Dye | WARFARE; DMMP; CHEMOSENSORS; SIMULANT; DERIVATIVES; COMPLEXES; EMISSION; ACID | Aggregation; Dye; Organophosphorus nerve agent; Vapochromism; Wearable sensor | Chemicals; Colorimetry; Detection; Dyes; Gas; Sensors; Textiles; Chemical detection; Chemical sensors; Chemical warfare; Color; Colorimetry; Gas detectors; Reusability; Textiles; Chemical gas sensors; Color changes; Detection performance; Dimethyl methylphosphonate; Functional dyes; Nerve agents; Organophosphorus nerve agent; Sensing mechanism; Textile substrates; Vapochromism; Wearable sensors | English | 2024 | 2024-04 | 10.1007/s10570-024-05772-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparison of Metabarcoding and Microscopy Methodologies to Analyze Diatom Communities in Five Estuaries Along the Southern Coast of the Korean Peninsula | The study of microalgal communities is critical for understanding aquatic ecosystems. These communities primarily comprise diatoms (Heterokontophyta), with two methods commonly used to study them: Microscopy and metabarcoding. However, these two methods often deliver different results; thus, their suitability for analyzing diatom communities is frequently debated and evaluated. This study used these two methods to analyze the diatom communities in identical water samples and compare the results. The taxonomy of the species constituting the diatom communities was confirmed, and both methods showed that species belonging to the orders Bacillariales and Naviculales (class Bacillariophyceae) are the most diverse. In the lower taxonomic levels (family, genus, and species), microscopy tended to show a bias toward detecting diatom species (Nitzschia frustulum, Nitzschia inconspicua, Nitzschia intermedia, Navicula gregaria, Navicula perminuta, Navicula recens, Navicula sp.) belonging to the Bacillariaceae and Naviculaceae families. The results of the two methods differed in identifying diatom species in the communities and analyzing their structural characteristics. These results are consistent with the fact that diatoms belonging to the genera Nitzschia and Navicula are abundant in the communities; furthermore, only the Illumina MiSeq data showed the abundance of the Melosira and Entomoneis genera. The results obtained from microscopy were superior to those of Illumina MiSeq regarding species-level identification. Based on the results obtained via microscopy and Illumina MiSeq, it was revealed that neither method is perfect and that each has clear strengths and weaknesses. Therefore, to analyze diatom communities effectively and accurately, these two methods should be combined. | Kim, Young-Saeng; Yun, Hyun-Sik; Lee, Jae-Hak; Lee, Kyung-Lak; Choi, Jae-Sin; Won, Doo Hee; Kim, Yong Jae; Kim, Han-Soon; Yoon, Ho-Sung | Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Ulleung Do & Dok Do, Daegu 41566, South Korea; Kyungpook Natl Univ, Plus KNU Creat BioRes Grp BK21, Sch Life Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Adv Bioresource Res Ctr, Daegu 41566, South Korea; Natl Inst Environm Res, Water Environm Engn Res Div, Incheon 22689, South Korea; Korea Ecosyst Serv Inc, Doohee Inst Ecol Res, Ansan 15426, South Korea; Daejin Univ, Dept Biomed Sci, Pochon 11159, South Korea | 35798433500; 57215320824; 55690077600; 57201446081; 57199098900; 48661632300; 48661264400; 7410135359; 7402990205 | kimhsu@knu.ac.kr;hsy@knu.ac.kr; | MICROBIAL ECOLOGY | MICROB ECOL | 0095-3628 | 1432-184X | 87 | 1 | SCIE | ECOLOGY;MARINE & FRESHWATER BIOLOGY;MICROBIOLOGY | 2024 | 4 | 6.3 | 0 | 2025-05-07 | 1 | 1 | Heterokontophyta; Diatom community; Microalgal; Microscopy; Illumina MiSeq; Taxonomy | DNA EXTRACTION; DIVERSITY; WATER; REVEALS | Diatom community; Heterokontophyta; Illumina MiSeq; Microalgal; Microscopy; Taxonomy | Biodiversity; Diatoms; DNA Barcoding, Taxonomic; Ecosystem; Estuaries; Microscopy; Phylogeny; Republic of Korea; biodiversity; classification; comparative study; diatom; DNA barcoding; ecosystem; estuary; growth, development and aging; microscopy; phylogeny; procedures; South Korea | English | 2024 | 2024-12 | 10.1007/s00248-024-02396-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Bioimpedance-Guided Fluid Removal in Continuous KRT The VENUS Randomized Clinical Trial | Key PointsThis study, the sole randomized trial of its kind, proposes guidelines for fluid balance management in continuous KRT (CKRT) patients using bioimpedance.Despite this, bioimpedance analysis-guided volume management did not influence the proportion of patients achieving estimated euvolemia at 7 days into CKRT.Further investigation is needed to assess whether bioimpedance analysis guidance can facilitate rapid fluid removal in the early phase of CKRT for patients with AKI. BackgroundUltrafiltration with continuous KRT (CKRT) can be used to manage fluid balance in critically ill patients with AKI. We aimed to assess whether bioimpedance analysis (BIA)-guided volume management was more efficacious than conventional management for achieving estimated euvolemia (e-euvolemia) in CKRT-treated patients. MethodsIn a multicenter randomized controlled trial from July 2017 to July 2020, the patients with AKI requiring CKRT were eligible if the weight at the start of CKRT had increased by >= 5% compared with the weight at the time of admission or total body water (TBW)/height (H)(2) >= 13 L/m(2). We randomly assigned 208 patients to the control (conventional fluid management; n=103) and intervention groups (BIA-guided fluid management; n=105). The primary outcome was the proportion of attaining e-euvolemia 7 days postrandomization. E-euvolemia was defined as the difference between TBW/H-2 D7 and D0 was <-2.1 L/m2(2) or when TBW/H-2 measured on D-7 was <13 L/m(2). The 28-, 60-, and 90-day mortality rate were secondary outcomes. ResultsThe primary outcome occurred in 34 patients in the intervention group and 27 in the control group (47% versus 41%; P = 0.50). The mean value of TBW/H-2 measured on D-7 was the same at 13.9 L/m(2) in both groups. The differences between TBW/H-2 D-7 and D0 were -1.13 L/m(2) in the intervention group and -1.08 L/m(2) in the control group (P = 0.84). Patients in the intervention group had a significantly higher proportion of reaching e-euvolemia on D-1 than those in the control group (13% versus 4%, P = 0.02). Adverse events did not differ significantly between the groups. ConclusionsBIA-guided volume management did not affect the proportion of reaching the e-euvolemia at 7 days of the start of CKRT. Clinical Trial registry name and registration number:ClinicalTrials.gov, ID: NCT03330626 (Registered on November 6, 2017; seven study participants were retrospectively registered; nonetheless, Institutional Review Board approval of each institution was completed before study participant registration). | An, Jung Nam; Oh, Hyung Jung; Oh, Sohee; Rhee, Harin; Seong, Eun Young; Baek, Seon Ha; Ahn, Shin Young; Cho, Jang-Hee; Lee, Jung Pyo; Kim, Dong Ki; Ryu, Dong-Ryeol; Ahn, Soyeon; Kim, Sejoong | Hallym Univ, Sacred Heart Hosp, Dept Internal Med, Div Nephrol, Anyang, South Korea; Sheikh Khalifa Specialty Hosp, Dept Nephrol, Ras Al Khaymah, U Arab Emirates; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Biostat, Seoul, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, Div Nephrol, Busan, South Korea; Hallym Univ, Dongtan Sacred Heart Hosp, Dept Internal Med, Div Nephrol, Hwaseong, South Korea; Korea Univ, Guro Hosp, Dept Internal Med, Div Nephrol, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Nephrol, Daegu, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Div Nephrol, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Div Nephrol, Seoul, South Korea; Ewha Womans Univ, Sch Med, Dept Internal Med, Div Nephrol, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Med Res Collaborating Ctr, Seongnam, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Div Nephrol, Seongnam, South Korea | Ahn, Soyeon/NES-1216-2025; Cho, Jang-hee/ABD-3534-2020 | 55286660300; 8931430000; 55509767900; 25951613200; 15726817400; 54957359000; 55313081300; 7403536291; 56028990400; 23479259100; 56669926200; 57219957528; 58758248900 | sejoong@snubh.org; | CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | CLIN J AM SOC NEPHRO | 1555-9041 | 1555-905X | 19 | 12 | SCIE | UROLOGY & NEPHROLOGY | 2024 | 7.1 | 6.4 | 0.64 | 2025-05-07 | 1 | 1 | ACUTE KIDNEY INJURY; BIOELECTRICAL-IMPEDANCE ANALYSIS; RENAL REPLACEMENT THERAPY; CRITICALLY-ILL PATIENTS; CONTINUOUS VENOVENOUS HEMOFILTRATION; SEPTIC PATIENTS; MANAGEMENT; BALANCE; INITIATION; MORTALITY | AKI | alanine aminotransferase; aspartate aminotransferase; creatinine; lactic acid; acute kidney failure; aged; Article; artificial ventilation; bioelectrical impedance analysis; body mass; Charlson Comorbidity Index; chronic kidney failure; continuous hemodiafiltration; continuous renal replacement therapy; controlled study; coronary artery disease; critically ill patient; emergency ward; estimated glomerular filtration rate; female; fluid balance; fluid resuscitation; heart failure; hemodiafiltration; hemodialysis; human; hypertension; impedance; intensive care unit; kidney function; liver disease; major clinical study; male; mortality rate; multicenter study; outcome assessment; peritoneal dialysis; potassium blood level; prospective study; quality control; randomized controlled trial; renal replacement therapy; resuscitation; retrospective study; risk assessment; Sequential Organ Failure Assessment Score; total body water; ultrafiltration; urine volume; adult; article; bioelectrical impedance analysis; continuous renal replacement therapy; fluid balance; special situation for pharmacovigilance | English | 2024 | 2024-12 | 10.2215/cjn.0000000000000557 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Homology-independent targeted insertion-mediated derivation of M1-biased macrophages harbouring Megf10 and CD31; 1; from human pluripotent stem cells | Background Macrophages engineered with chimeric antigen receptors (CAR) are suitable for immunotherapy based on their immunomodulatory activity and ability to infiltrate fi ltrate solid tumours. However, the production and application of genetically edited, highly effective, and mass-produced CAR-modified fi ed macrophages (CAR-Ms) are challenging. Methods Here, we used homology-independent targeted insertion (HITI) for site-directed CAR integration into the safe-harbour region of human pluripotent stem cells (hPSCs). This approach, together with a simple differentiation protocol, produced stable and highly effective CAR-Ms without heterogeneity. Findings These engineered cells phagocytosed cancer cells, leading to significant fi cant inhibition of cancer-cell proliferation in vitro and in vivo. . Furthermore, the engineered CARs, which incorporated a combination of CD31; 1; and Megf10 (referred to as FRP5M1;), M 1; ), markedly enhanced the antitumour effect of CAR-Ms by promoting M1, but not M2, polarisation. FRP5M1; M 1; promoted M1 polarisation via nuclear factor kappa B (NF-KB), K B), ERK, and STAT1 signalling, and concurrently inhibited STAT3 signalling even under M2 conditions. These features of CAR-Ms modulated the tumour microenvironment by activating inflammatory fl ammatory signalling, inducing M1 polarisation of bystander non-CAR macrophages, and enhancing the infiltration fi ltration of T cells in cancer spheroids. Interpretation Our fi ndings suggest that CAR-Ms have promise as immunotherapeutics. In conclusion, the guided insertion of CAR containing CD31; 1; and Megf10 domains is an effective strategy for the immunotherapy of solid tumours. | Zhen, Xing; Kim, Jieun; Kang, Jong Soon; Choi, Byeong Jo; Park, Ki Hwan; Lee, Dong-Seok; Hong, Seok-Ho; Lee, Jong-Hee | Korea Res Inst Biosci & Biotechnol KRIBB, Natl Primate Res Ctr NPRC, Cheongju 28116, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Nanosci & Nanotechnol, Daegu 41566, South Korea; Univ Sci & Technol UST, KRIBB Sch Biosci, Dept Funct Genom, Daejeon 34113, South Korea; Catholic Univ Korea, Coll Med, Dept Med Life Sci, Seoul 06591, South Korea; Catholic Univ Korea, Coll Med, Dept Biomed & Hlth Sci, Seoul 06591, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Lab Anim Resource & Res Ctr, Cheongju 28116, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Kangwon Natl Univ, Sch Med, Dept Internal Med, Chunchon 24341, South Korea; KW Bio Co Ltd, Chunchon 24252, South Korea | 57221725411; 57221729863; 55541273300; 57218287860; 57190061399; 57210068061; 34769814700; 57203736066 | jonglee@kribb.re.kr;zhenxing93@kribb.re.kr;jieun622@kribb.re.kr;byung127@kribb.re.kr;kanjon@kribb.re.kr;brightnessd@kribb.re.kr;shhong@kangwon.ac.kr;lee1@knu.ac.kr; | EBIOMEDICINE | EBIOMEDICINE | 2352-3964 | 109 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 10.8 | 6.4 | 0.93 | 2025-05-07 | 4 | 4 | Immunotherapy; Chimeric antigen receptor (CAR)-Modified fi ed macrophage; Human pluripotent stem cell (hPSC); Homology-independent targeted insertion (HITI); CD31; Megf10 | T-CELLS; CANCER; DESIGN | CD3ζ; Chimeric antigen receptor (CAR)-Modified macrophage; Homology-independent targeted insertion (HITI); Human pluripotent stem cell (hPSC); Immunotherapy; Megf10 | Animals; CD3 Complex; Cell Differentiation; Cell Line, Tumor; Humans; Macrophages; Mice; Pluripotent Stem Cells; Receptors, Chimeric Antigen; Signal Transduction; Tumor Microenvironment; CD28 antigen; CD3 antibody; epidermal growth factor receptor 2; gamma interferon; granulocyte colony stimulating factor; immunoglobulin enhancer binding protein; interleukin 13; octamer transcription factor 4; secreted frizzled related protein 5; STAT3 protein; T lymphocyte receptor; transcription factor NANOG; transcription factor Sox2; transforming growth factor beta; vasculotropin; CD3 antigen; CD3 antigen, zeta chain; chimeric antigen receptor; animal cell; antineoplastic activity; apoptosis; Article; AU565 cell line; breast cancer; cancer immunotherapy; carcinogenesis; cell differentiation; cell differentiation assay; cell infiltration; cell invasion; cell proliferation; cell separation; controlled study; CRISPR-CAS9 system; cytokine release; cytotoxicity; cytotoxicity assay; endothelial progenitor cell; enzyme linked immunosorbent assay; female; flow cytometry; fluorescence microscopy; gene expression; homology independent targeted insertion; human; human cell; immune response; immunocytochemistry; immunofluorescence assay; immunosuppressive treatment; immunotherapy; Jurkat cell line; Jurkat E6.1 cell line; karyotyping; macrophage; MDA-MB-231 cell line; mouse; natural killer cell; phagocytosis; phenotype; pluripotent stem cell; polyacrylamide gel electrophoresis; protein expression; real time polymerase chain reaction; reverse transcription polymerase chain reaction; sequence homology; SK-OV-3 cell line; T lymphocyte; transwell assay; tumor growth; tumor microenvironment; tumor spheroid; tumor volume; Western blotting; animal; cytology; genetics; immunology; metabolism; signal transduction; tumor cell line | English | 2024 | 2024-11 | 10.1016/j.ebiom.2024.105390 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | IL-1 receptor 1 signaling shapes the development of viral antigen-specific fi c CD4+ | Background The innate immune cytokine interleukin (IL)-1 can affect T cell immunity, a critical factor in host defense. In a previous study, we identified fi ed a subset of human CD4+ + T cells which express IL-1 receptor 1 (IL-1R1). However, the expression of such receptor by viral antigen-specific fi c CD4+ + T cells and its biological implication remain largely unexplored. This led us to investigate the implication of IL-1R1 in the development of viral antigen-specific fi c CD4+ + T cell responses in humans, including healthy individuals and patients with primary antibody deficiency fi ciency (PAD), and animals. Methods We characterized CD4+ + T cells specific fi c for SARS-CoV-2 spike (S) protein, influenza fl uenza virus, and cytomegalovirus utilizing multiplexed single cell RNA-seq, mass cytometry and fl ow cytometry followed by an animal study. Findings In healthy individuals, CD4+ + T cells specific fi c for viral antigens, including S protein, highly expressed IL-1R1. IL-1 beta beta promoted interferon (IFN)-gamma gamma expression by S protein-stimulated CD4+ + T cells, supporting the functional implication of IL-1R1. Following the 2nd dose of COVID-19 mRNA vaccines, S protein-specific fi c CD4+ + T cells with high levels of IL-1R1 increased, likely reflecting fl ecting repetitive antigenic stimulation. The expression levels of IL-1R1 by such cells correlated with the development of serum anti-S protein IgG antibody. A similar fi nding of increased expression of IL-1R1 by S protein-specific fi c CD4+ + T cells was also observed in patients with PAD following COVID-19 mRNA vaccination although the expression levels of IL-1R1 by such cells did not correlate with the levels of serum anti-S protein IgG antibody. In mice immunized with COVID-19 mRNA vaccine, neutralizing IL-1R1 decreased IFN-gamma gamma expression by S protein-specific fi c CD4+ + T cells and the development of anti-S protein IgG antibody. Interpretation Our results demonstrate the significance fi cance of IL-1R1 expression in CD4+ + T cells for the development of viral antigen-specific fi c CD4+ + T cell responses, contributing to humoral immunity. This provides an insight into the regulation of adaptive immune responses to viruses via the IL-1 and IL-1R1 interface. Funding Moderna to HJP, National Institutes of Health (NIH) 1R01AG056728 and R01AG055362 to IK and KL2 TR001862 to JJS, Quest Diagnostics to IK and RB, and the Mathers Foundation to RB. | Park, Hong-Jai; Shin, Min Sun; Shin, Junghee J.; Kim, Hyoungsu; Kang, Byunghyun; Par-Young, Jennefer; Unlu, Serhan; Afinogenova, Yuliya; Catanzaro, Jason; Young, Juan; Kim, Minhyung; Lee, Sang Jin; Jeon, Sangchoon; You, Sungyong; Racke, Michael K.; Bucala, Richard; Kang, Insoo | Yale Univ, Sch Med, Dept Internal Med, Sect Rheumatol Allergy & Immunol, New Haven, CT 06520 USA; Hallym Univ, Sch Med, Dept Internal Med, Nanobio Regenerat Med Inst, Chunchon 24252, Gangwon Do, South Korea; NIH, NIAID, Mucosal Immunol Sect, Lab Mol Immunol, Bethesda, MD 20892 USA; Yale Univ, Sch Med, Dept Pediat, Sect Pulm Allergy Immunol & Sleep Med, New Haven, CT 06520 USA; Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA; Cedars Sinai Med Ctr, Dept Surg, Los Angeles, CA 90048 USA; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Yale Univ, Sch Nursing, West Haven, CT 06516 USA; Quest Diagnost, 500 Plaza Dr, Secaucus, NJ 07094 USA | ; Jeon, Sangchoon/E-3800-2013; You, Sungyong/AAJ-7372-2020 | 56233299400; 56568662300; 57216785578; 59704987600; 57217433477; 57270991600; 57270667000; 55270238300; 57202978318; 58025614100; 57203466485; 57192516055; 7203005741; 24069443900; 7006285738; 57203070150; 7203062711 | insoo.kang@yale.edu; | EBIOMEDICINE | EBIOMEDICINE | 2352-3964 | 103 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 10.8 | 6.4 | 0.31 | 2025-05-07 | 2 | 2 | T-CELLS; IL-1-BETA PRODUCTION; EFFECTOR; EXPRESSION; MONOCYTES; RESPONSES; NAIVE | Antigen-specific T cells; COVID-19; IL-1 receptors; IL-1β; mRNA vaccines; Primary antibody deficiency | Animals; Antibodies, Viral; Antigens, Viral; CD4-Positive T-Lymphocytes; COVID-19; COVID-19 Vaccines; Female; Humans; Interferon-gamma; Mice; mRNA Vaccines; Receptors, Interleukin-1 Type I; SARS-CoV-2; Signal Transduction; Spike Glycoprotein, Coronavirus; Vaccination; cisplatin; coronavirus spike glycoprotein; elasomeran; gamma interferon; immunoglobulin G antibody; interleukin 1; interleukin 1 receptor 1; interleukin 1beta; interleukin receptor; neutralizing antibody; SARS-CoV-2 vaccine; tozinameran; unclassified drug; virus antigen; coronavirus spike glycoprotein; gamma interferon; interleukin 1 receptor type I; RNA vaccine; SARS-CoV-2 vaccine; virus antibody; virus antigen; adult; animal experiment; Article; CD4+ T lymphocyte; coronavirus disease 2019; enzyme linked immunosorbent assay; female; flow cytometry; gene set enrichment analysis; human; human cell; human experiment; humoral immune deficiency; immune response; immune system; Influenza virus; interleukin signaling; male; mass cytometry; mouse; nonhuman; normal human; peripheral blood mononuclear cell; protein expression; RNA sequence; single cell RNA seq; vaccination; animal; blood; coronavirus disease 2019; genetics; immunology; metabolism; Severe acute respiratory syndrome coronavirus 2; signal transduction; vaccination | English | 2024 | 2024-05 | 10.1016/j.ebiom.2024.105114 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Meeting Abstract | mRECIST Outcomes in EMERALD-1: A Phase 3, Randomized, Placebo-Controlled Study of Transarterial Chemoembolization plus Durvalumab with or without Bevacizumab in Participants with Embolization-Eligible Hepatocellular Carcinoma | Sangro, B.; Kudo, M.; Erinjeri, J. P.; Qin, S.; Ren, Z.; Chan, S.; Arai, Y.; Heo, J.; Mai, A.; Penagos, F. E.; Chuken, Y. A. Lopez; Yoon, J. H.; Tak, W. Y.; Suttichaimongkol, T.; Bouattour, M.; Lin, S. M.; Zotkiewicz, M.; Ai, S.; Cohen, G. J.; Lencioni, R. | Clin Univ Navarra, Liver Unit, Pamplona, Spain; Clin Univ Navarra, HPB Oncol Area, Pamplona, Spain; CIBEREHD, Pamplona, Spain; Kindai Univ, Dept Gastroenterol & Hepatol, Fac Med, Osaka, Japan; Mem Sloan Kettering Canc Ctr, lntervent Radiol Serv, New York, NY USA; Jinling Hosp, Canc Ctr Nanjing, Nanjing, Peoples R China; Fudan Univ, Liver Canc Inst, Zhongshan Hosp, Dept Hepat Oncol, Shanghai, Peoples R China; Chinese Univ Hong Kong, Dept Clin Oncol, State Key Lab Translat Oncol, Sir Yue Kong Pao Ctr Canc, Hong Kong, Peoples R China; Natl Canc Ctr, Dept Diagnost Radiol, Chuo Ku, Tokyo, Japan; Pusan Natl Univ, Dept Internal Med, Coll Med, Busan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea; Nhan Dan Gia Dinh Hosp, Gen Surg Dept, Ho Chi Minh City, Vietnam; Hosp San Lucas Cardiol Sureste, Chiapas, Mexico; I Can Oncol Ctr, New Leon, Mexico; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Liver Res Inst, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Khon Kaen Univ, Dept Med, Div Gastroenterol & Hepatol, Fac Med, Khon Kaen, Thailand; Hop Beaujon, AP HP, Med Oncol, Paris, France; Chang Gung Mem Hosp, Linkou Med Ctr, Dept Internal Med, Taoyuan, Taiwan; AstraZeneca, Late Oncol Stat, Oncol Biometr, Warsaw, Poland; AstraZeneca, Late Dev Oncol, Cambridge, England; AstraZeneca, Global Med Dev, Gaithersburg, MD USA; Univ Pisa, Dept Diagnost & Intervent Radiol, Sch Med, Pisa, Italy | Heo, Jeong/MHQ-1390-2025; Yoon, Jeong Hee/ABA-5127-2021; Sangro, Bruno/AFW-4106-2022; Kudo, Masatoshi/AAA-9744-2019 | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | INT J RADIAT ONCOL | 0360-3016 | 1879-355X | 120 | 2 | SCIE | ONCOLOGY;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2024 | 6.5 | 6.4 | 0 | English | 2024 | 2024-10-01 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | Prevalence and Outcomes of Chronic Kidney Disease-Associated Pruritus | Key PointsCKD-associated pruritus is highly prevalent among peritoneal dialysis patients.Pruritus is associated with reduced health-related quality of life, and the composite of mortality and transfer to hemodialysis for peritoneal dialysis patients.Efforts to better identify and manage pruritus in this population are needed.BackgroundPruritus is common in hemodialysis patients. Less is known about the prevalence and outcomes of pruritus among patients receiving peritoneal dialysis (PD). Herein, we describe the prevalence of pruritus and its associations with patient-reported outcomes (PROs) and mortality/transfer to hemodialysis.MethodsWe analyzed a multicenter, international cohort of PD patients enrolled in the PD Outcomes and Practice Patterns Study from 2014 to 2022. Pruritus was assessed at entry into the PD Outcomes and Practice Patterns Study with a single-question Likert Scale capturing the extent to which patients were bothered by itch ranging from 1: not at all to 5: extremely. The kidney disease quality of life-36 and the Center for Epidemiological Studies Depression Scale assessed various PROs. Moderate-to-extreme pruritus was defined as a Likert scale score >= 3. The associations of pruritus with PROs were assessed using linear/logistic regression where appropriate. Death or hemodialysis transfer was assessed using multivariable Cox regression models.ResultsOverall, 5535 patients from eight countries were included; 43% had moderate-to-extreme pruritus which was the highest in Thailand (50%) and the lowest in the United States (33%). The adjusted odds ratios of moderate-to-extreme pruritus were higher for diabetes, low albumin, and elevated phosphorus but lower for residual urine volume (adjusted odds ratio, 0.98 per 200 ml increase in 24-hour urine volume; 95% confidence interval, 0.96 to 1.00; P = 0.05). Patients with extreme pruritus had the lowest mental and physical health component scores and a higher burden of other PROs including restless legs and disturbed sleep. Overall, 921 patients died and 1150 were transferred to hemodialysis. Patients with moderate-to-extreme pruritus were at higher adjusted risk for death or hemodialysis transfer (adjusted hazard ratio, 1.12; 95% confidence interval, 1.02 to 1.23; P = 0.02) with similar point estimates for each subcomponent of the composite outcome.ConclusionsPruritus is highly prevalent in PD and associated with poor health outcomes. Efforts to better identify and manage pruritus should be considered in this population. | Tennankore, Karthik K.; Mccullough, Keith; Bieber, Brian; Cho, Yeoungjee; Johnson, David W.; Kanjanabuch, Talerngsak; Kawanishi, Hideki; Kim, Yong-Lim; Lambie, Mark; Rigatto, Claudio; Shen, Jenny; Schreiber, Martin; Perl, Jeffrey; Pisoni, Ronald L. | Dalhousie Univ, Dept Med, Halifax, NS, Canada; Arbor Res Collaborat Hlth, Ann Arbor, MI USA; Princess Alexandra Hosp, Dept Kidney & Transplant Serv, Brisbane, Qld, Australia; Univ Queensland, Ctr Hlth Serv Res, Australasian Kidney Trials Network, Brisbane, Qld, Australia; Translat Res Inst, Brisbane, Qld, Australia; Chulalongkorn Univ, Fac Med, Dept Med, Div Nephrol, Bangkok, Thailand; Chulalongkorn Univ, Fac Med, Ctr Excellence Kidney Metab Disorders, Bangkok, Thailand; Tsuchiya Gen Hosp, Dept Artificial Organs, Hiroshima, Japan; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Nephrol, Daegu, South Korea; Keele Univ, Sch Med, Stoke On Trent, England; Univ Hosp North Midlands, Renal Unit, Stoke On Trent, England; Univ Manitoba, Chron Dis Innovat Ctr, Winnipeg, MB, Canada; Harbor UCLA Med Ctr, Lundquist Inst, Torrance, CA USA; DaVita Integrated Kidney Care, Denver, CO USA; Univ Toronto, Dept Med, Div Gastroenterol, Div Nephrol,Unity Hlth, Toronto, ON, Canada | Kim, Yong-Lim/AGK-3172-2022; Johnson, David/F-2897-2011; Cho, Yeoungjee/G-6176-2013; Rigatto, Claudio/JNS-0494-2023; Lambie, Mark/AAA-9104-2020; Tennankore, Karthik/K-6600-2019; Perl, Jeffrey/HKW-4066-2023 | 40462442800; 57197188719; 53982698300; 35182599800; 34975083900; 13609834900; 7103248513; 55633533600; 17135424200; 6601967319; 55207588700; 57201514473; 57192120457; 7004217145 | KarthikK.Tennankore@nshealth.ca; | CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | CLIN J AM SOC NEPHRO | 1555-9041 | 1555-905X | 19 | 12 | SCIE | UROLOGY & NEPHROLOGY | 2024 | 7.1 | 6.4 | 0.64 | 2025-05-07 | 1 | 2 | clinical epidemiology; dialysis; patient self-assessment; patient-centered care; peritoneal dialysis; quality of life; survival | QUALITY-OF-LIFE; PERITONEAL-DIALYSIS OUTCOMES; SELF-REPORTED PRURITUS; PRACTICE PATTERNS; UREMIC PRURITUS; GLOBAL OUTCOMES; BURDEN; IMPACT; SCALE; CKD | clinical epidemiology; dialysis; patient self-Assessment; patient-centered care; peritoneal dialysis; quality of life; survival | albumin; antihistaminic agent; gabapentin; nalfurafine; phosphorus; potassium; pregabalin; adult; aged; Article; Center for Epidemiological Studies Depression Scale; chronic kidney failure; clinical outcome; cohort analysis; depression; diabetes mellitus; disease severity; face validity; female; follow up; hemodialysis; human; KDQOL-36; Likert scale; major clinical study; male; mortality; multicenter study; patient-reported outcome; peritoneal dialysis; postvoid residual urine volume; prevalence; prospective study; pruritus; questionnaire; restless legs syndrome; sensitivity analysis; sleep disorder; sleep quality; treatment failure; article; chronic kidney failure; controlled study; pruritus | English | 2024 | 2024-12 | 10.2215/cjn.0000000000000537 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Voltammetric Aptamer-Based Biochip Featuring Poly Gallic Acid/SnO2-MoO3 Nanocomposite for Selective Tryptophan Detection: Potential Application in Alzheimer's Diagnosis | Tryptophan (Trp) levels are associated with Alzheimer's disease (AD), suggesting its utility as a diagnostic marker in AD patients. In this study, a disposable screen-printed carbon electrode modified with an aptamer, poly gallic acid, and SnO2-MoO3 nanoparticles (Apt/p-GA/SnO2-MoO3/SPCE) was demonstrated for voltammetric selective detection of Trp in clinical plasma samples. X-ray photoelectron and impedance spectroscopy, along with cyclic voltammetry, revealed that SnO2-MoO3 nanoparticles enlarged an effective surface area, while p-GA enhanced aptamer immobilization leading to selectivity for target molecules. The synergistic effects of these components promote excellent electron transfer to Trp. Differential pulse voltammetric measurements for Trp oxidation with Apt/p-GA/SnO2-MoO3/SPCE provided a wide linear range (0.5-100 mu M) and a low limit of detection (0.189 mu M) with a reasonable sensitivity (0.352 mu A mu M-1 cm(-2)), comparable to the reported single metal oxide-based composite electrodes. Further application of the aptasensor to clinical plasma samples from healthy individuals and AD patients revealed an effective reduction of matrix effects during Trp analysis. The sample analysis results were also closely correlated with those obtained using the enzyme-linked immunosorbent assay, highlighting the accuracy and practical utility of the sensor for clinical assessment. | Lee, Seung Hyeon; Nde, Dieudonne Tanue; Li, Jingjing; Koh, Eunchan; Lu, Jiaran; Lee, Myungseob; Karuppiah, Chelladurai; Lee, Hye Jin | Kyungpook Natl Univ, Dept Chem & Green Nano Mat, Res Ctr, 80 Daehakro, Daegu City 41566, South Korea | Karuppiah, Chelladurai/H-7068-2019; LEE, HYEJIN/W-1345-2018 | 59391330000; 57240825500; 57222707218; 59391498700; 59390988900; 59303042200; 55910716400; 56569175200 | kcdurai.rmd@gmail.com;hyejinlee@knu.ac.kr; | BIOCHIP JOURNAL | BIOCHIP J | 1976-0280 | 2092-7843 | 18 | 4 | SCIE | BIOCHEMICAL RESEARCH METHODS;CHEMISTRY, ANALYTICAL;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 6.1 | 6.4 | 0 | 2025-05-07 | 0 | 0 | Binary metal oxides; Electrochemical aptasensor; Tryptophan; Electropolymerization; DNA aptamer; Alzheimer's disease | SERUM; SENSOR | Alzheimer's disease; Binary metal oxides; DNA aptamer; Electrochemical aptasensor; Electropolymerization; Tryptophan | Electropolymerization; Gallium compounds; Nanoparticles; X ray photoelectron spectroscopy; Alzheimers disease; Aptamers; Binary metal oxides; Dna aptamer; Electrochemical aptasensor; Electropolymerisation; MoO 3; SnO 2; Tryptophan; Voltammetric; Cyclic voltammetry | English | 2024 | 2024-12 | 10.1007/s13206-024-00175-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | A review of metal-organic framework-based membranes for the removal of emerging contaminants from water | Metal-organic frameworks (MOFs) have shown significant promise in the removal of contaminants of emerging concern (CECs) from water. The integration of MOFs into forward osmosis (FO), nanofiltration (NF), and ultrafiltration (UF) membranes can reduce membrane fouling, improve the removal of CECs, and enhance water permeability. Thus, the use of MOF-based membranes in water purification has been reviewed in several recent studies, which covered both conventional and emerging contaminants. However, to comprehensively understand how MOF-based membranes work for the removal of emerging contaminants, a systematic review must be conducted in this regard as the removal of emerging contaminants depends heavily on compound properties, water chemistry, membrane properties, and operating conditions. In this review, we focused mainly on various types of MOFs used in FO, NF, and UF membranes. Overall findings have shown that the removal of CECs by MOF-based membranes could be improved by modifying/enhancing the properties of membrane such as porosity/pore structure, surface roughness, hydrophilicity, mechanical strength, chemical stability, fouling resistance, and/or adsorption capacity, while the removal degree and the permeance of the membranes could still vary depending on target compounds and water quality conditions. The main objective of this study was to investigate the contaminant/membrane properties of different MOF-based membranes and their preparation methods and purification performance. This study also briefly discussed potential research areas where knowledge gaps still exist. | Choi, Jong Soo; Jung, Bongyeon; Kim, Hak-Hyeon; Heo, Jiyong; Park, Chang Min; Jang, Min; Nam, Seong-Nam; Huang, Yi; Jun, Byung-Moon; Yoon, Yeomin | Ewha Womans Univ, Dept Environm Sci & Engn, 52 Ewhayeodae Gil, Seoul 03760, South Korea; Korea Army Acad Yeongcheon, Mil Environm Res Ctr, 495 Hoguk Ro, Yeongcheon Si 38900, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kwangwoon Univ, Dept Environm Engn, 447-1 Wolgye Dong Nowon Gu, Seoul, South Korea; Univ Edinburgh, Inst Mat & Proc, Sch Engn, Robert Stevenson Rd, Edinburgh EH9 3FB, Scotland; Kyung Hee Univ, Dept Environm Sci & Engn, 1732 Deogyeong Daero, Yongin 17104, Gyeonggi Do, South Korea; Ctr SEBIS Strateg Solut Environm Blindspots Intere, 52 Ewhayeodae Gil, Seoul 03760, South Korea | Jang, Min/M-6690-2018; Jang, Min/J-2230-2012; Nam, Seong-Nam/ABT-9415-2022; Kim, Hak-Hyeon/ABE-1614-2021; Yoon, Yeomin/KDP-2253-2024; Jun, Byung-Moon/Y-2134-2019; Park, Chang Min/CAA-8506-2022 | 57202287234; 57211690823; 56683717600; 42461338400; 57209588953; 36762550700; 57226757907; 55717272000; 55326699900; 7402126688 | jbm9101@khu.ac.kr;yoony@ewha.ac.kr; | JOURNAL OF WATER PROCESS ENGINEERING | J WATER PROCESS ENG | 2214-7144 | 68 | SCIE | ENGINEERING, CHEMICAL;WATER RESOURCES;ENGINEERING, ENVIRONMENTAL | 2024 | 6.7 | 6.5 | 0 | 2025-05-07 | 1 | 1 | Metal-organic frameworks; Membrane; Contaminants of emerging concern; Water treatment | THIN-FILM NANOCOMPOSITE; PERSONAL CARE PRODUCTS; COMPOSITE MEMBRANES; WASTE-WATER; OSMOSIS MEMBRANE; REVERSE-OSMOSIS; GRAPHENE OXIDE; CARBON NANOTUBES; PHARMACEUTICAL COMPOUNDS; ANTIFOULING PROPERTIES | Contaminants of emerging concern; Membrane; Metal-organic frameworks; Water treatment | English | 2024 | 2024-12 | 10.1016/j.jwpe.2024.106456 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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