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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Ti-containing 316L stainless steels with excellent tensile properties fabricated by directed energy deposition additive manufacturing | Additive manufacturing is used to produce complex shapes, and it has been actively investigated. In this study, 316L stainless steels with various amounts of Ti were fabricated using directed energy deposition. The addition of Ti changed the microstructure and significantly improved the tensile properties of austenitic stainless steels. The addition of Ti led to distinct microstructural evolutions, such as changes in the cellular structure, grain size and Ti-rich particle. Microstructural changes such as change in change to equiaxed cellular structure and grain refimenet were due to Ti-rich particles acting as new nucleation sites and suppressing the segregation of solute atoms. In particular, the yield strength, tensile strength, and elongation of the specimen with 2 wt% Ti were 637 MPa, 857 MPa, and 43%, respectively, which were considerably higher than those of 316L stainless steel without Ti. Therefore, the addition of Ti is a suitable strategy for improving the tensile properties of additively manu-factured 316L stainless steel. | Han, Soo Bin; Lee, Yoon Sun; Park, Sung Hyuk; Song, Hyejin | Korea Inst Ind Technol, Smart Mfg Technol R&D Grp, Daegu 72994, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea | ; Park, Sung-Hyuk/AAE-6726-2022 | 57996703700; 57202036132; 54786002500; 56707858600 | shyejin@kitech.re.kr; | MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING | MAT SCI ENG A-STRUCT | 0921-5093 | 1873-4936 | 862 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;NANOSCIENCE & NANOTECHNOLOGY | 2023 | 6.1 | 7.2 | 2.58 | 2025-06-25 | 23 | 23 | Additive manufacturing; Austenitic stainless steel; Microstructure; Mechanical properties | HIGH-ENTROPY ALLOY; DISLOCATION-STRUCTURES; YIELD STRENGTH; BEHAVIOR; MICROSTRUCTURE; DUCTILITY | Additive manufacturing; Austenitic stainless steel; Mechanical properties; Microstructure | 3D printers; Additives; Cellular automata; Deposition; Fabrication; Tensile strength; Textures; 316 L stainless steel; Cellular structure; Complex shapes; Directed energy; Energy depositions; Grainsize; Manufacturing IS; Microstructural changes; Nucleation sites; Solute atoms; Austenitic stainless steel | English | 2023 | 2023-01-18 | 10.1016/j.msea.2022.144414 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Crystal Structure and Functional Characterization of Acetylornithine Aminotransferase from Corynebacterium glutamicum | The amino acids l-arginine and l-ornithine are widely used in animal feed and as health supplements and pharmaceutical compounds. In arginine biosynthesis, acetylornithine aminotransferase (AcOAT) uses pyridoxal-5 '-phosphate (PLP) as a cofactor for amino group transfer. Here, we determined the crystal structures of the apo and PLP complex forms of AcOAT from Corynebacterium glutamicum (CgAcOAT). Our structural observations revealed that CgAcOAT undergoes an order-to-disorder conformational change upon binding with PLP. Additionally, we observed that unlike other AcOATs, CgAcOAT exists as a tetramer. Subsequently, we identified the key residues involved in PLP and substrate binding based on structural analysis and site-directed mutagenesis. This study might provide structural insights on CgAcOAT, which can be utilized for the development of improved l-arginine production enzymes. | Ki, Dongwoo; Hong, Hwaseok; Kim, Il-kwon; Kim, Kyung-Jin | Kyungpook Natl Univ, KNU Inst Microorganisms, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea | ; Kim, Hee/F-4594-2014 | 57219308133; 57208592877; 56547774100; 55510867400 | kkim@knu.ac.kr; | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | J AGR FOOD CHEM | 0021-8561 | 1520-5118 | 71 | 22 | SCIE | AGRICULTURE, MULTIDISCIPLINARY;CHEMISTRY, APPLIED;FOOD SCIENCE & TECHNOLOGY | 2023 | 5.7 | 7.3 | 0.16 | 2025-06-25 | 1 | 1 | l-arginine; acetylornithine aminotransferase; Corynebacterium glutamicum; crystal structure; pyridoxal-5 '-phosphate | AMINO-ACIDS; SUBSTRATE-SPECIFICITY; L-ARGININE; FERMENTATION; ENZYMES | acetylornithine aminotransferase; Corynebacterium glutamicum; crystal structure; l- arginine; pyridoxal-5′-phosphate | Arginine; Corynebacterium glutamicum; Crystallography, X-Ray; Mutagenesis, Site-Directed; Transaminases; Arginine; Biochemistry; Positive ions; aminotransferase; arginine; Acetylornithine aminotransferase; Amino-acids; Aminotransferase; Animal feed; Corynebacterium glutamicum; Crystals structures; Functional characterization; L-Arginine; Pyridoxal 5′-phosphate; Structure characterization; Corynebacterium glutamicum; genetics; metabolism; site directed mutagenesis; X ray crystallography; Crystal structure | English | 2023 | 2023-05-25 | 10.1021/acs.jafc.3c00659 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Structural and Biochemical Studies on Product Inhibition of S-Adenosylmethionine Synthetase from Corynebacterium glutamicum | S-Adenosylmethionine (SAM) acts as a methyl donor in living organisms, and S-adenosylmethionine synthetase (MetK) is an essential enzyme for cells, as it synthesizes SAM from methionine and adenosine triphosphate (ATP). This study determined the crystal structures of the apo form and adenosine/triphosphate complex form of MetK from Corynebacterium glutamicum (CgMetK). Results showed that CgMetK has an allosteric inhibitor binding site for the SAM product in the vicinity of the active site and is inhibited by SAM both competitively and noncompetitively. Through structure-guided protein engineering, the CgMetK(E68A) variant was developed that exhibited an almost complete release of inhibition by SAM with rather enhanced enzyme activity. The crystal structure of the CgMetK(E68A) variant revealed that the formation of a new hydrogen bond between Tyr66 and Glu102 by the E68A mutation disrupted the allosteric SAM binding site and also improved the protein thermal stability by strengthening the tetramerization of the enzyme. | Lee, Seunghwan; Kim, Seongmin; Kim, Il-kwon; Kim, Kyung-Jin | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Microorganisms, Daegu 41566, South Korea | Kim, Kyung-Jin/MVY-3405-2025 | 57202327400; 57204760454; 56547774100; 55510867400 | kkim@knu.ac.kr; | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | J AGR FOOD CHEM | 0021-8561 | 1520-5118 | 71 | 42 | SCIE | AGRICULTURE, MULTIDISCIPLINARY;CHEMISTRY, APPLIED;FOOD SCIENCE & TECHNOLOGY | 2023 | 5.7 | 7.3 | 0.49 | 2025-06-25 | 3 | 4 | S-adenosylmethionine synthetase; Corynebacterium glutamicum; allosteric inhibition; protein engineering | CRYSTAL-STRUCTURE; BIOSYNTHESIS; LYSINE; RNA | allosteric inhibition; Corynebacterium glutamicum; protein engineering; S-adenosylmethionine synthetase | Adenosine Triphosphate; Corynebacterium glutamicum; Methionine; Methionine Adenosyltransferase; S-Adenosylmethionine; Adenosinetriphosphate; Amino acids; Binding sites; Enzyme activity; Enzyme inhibition; Hydrogen bonds; ademetionine; adenosine triphosphate; methionine; methionine adenosyltransferase; Adenosine triphosphate; Allosteric inhibition; Binding-sites; Biochemical studies; Corynebacterium glutamicum; Crystals structures; Protein engineering; S-adenosylmethionine; S-adenosylmethionine synthetase; Structural studies; chemistry; Corynebacterium glutamicum; genetics; metabolism; Crystal structure | English | 2023 | 2023-10-17 | 10.1021/acs.jafc.3c05180 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Structure-Guided Protein Engineering of Glyceraldehyde-3-phosphate Dehydrogenase from Corynebacterium glutamicum for Dual NAD/NADP Cofactor Specificity | Since the discovery of l-glutamate-producing Corynebacterium glutamicum, it has evolved to be an industrial workhorse. For biobased chemical production, suppling sufficient amounts of the NADPH cofactor is crucial. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme that converts glyceraldehyde-3-phosphate (G3P) to 1,3-bisphosphoglycerate and produces NADH, is a major prospective solution for the cofactor imbalance issue. In this study, we determined the crystal structure of GAPDH from C. glutamicum ATCC13032 (CgGAPDH). Based on the structural information, we generated six CgGAPDH variants, CgGAPDH(L36S), CgGAPDH(L36S/T37K), CgGAPDH(L36S/T37K/P192S), CgGAPDH(L36S/T37K/F100V/P192S), CgGAPDH(L36S/T37K/F100L/P192S), and CgGAPDH(L36S/T37K/F100I/P192S), that can produce both NADH and NAPDH. The final CgGAPDH(L36S/T37K/F100V/P192S) variant showed a 212-fold increase in enzyme activity for NADP as well as 200% and 30% increased activity for the G3P substrate under NAD and NADP cofactor conditions, respectively. In addition, crystal structures of CgGAPDH variants in complex with NAD(P) permit the elucidation of differences between wild-type CgGAPDH and variants in relation to cofactor stabilization. | Son, Hyeoncheol Francis; Yu, Hyeonjeong; Hong, Jiyeon; Lee, Donghoon; Kim, Il-Kwon; Kim, Kyung-Jin | Korea Inst Sci & Technol, Clean Energy Res Ctr, Seoul 02792, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Four KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Microorganisms, Daegu 41566, South Korea; DAESANG Corp, Ingredient Business Unit, Seoul 07789, South Korea | Kim, Kyung-Jin/MVY-3405-2025 | 56015598000; 58260376000; 57205354591; 57207418964; 56547774100; 55510867400 | kkim@knu.ac.kr; | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | J AGR FOOD CHEM | 0021-8561 | 1520-5118 | 71 | 46 | SCIE | AGRICULTURE, MULTIDISCIPLINARY;CHEMISTRY, APPLIED;FOOD SCIENCE & TECHNOLOGY | 2023 | 5.7 | 7.3 | 0.49 | 2025-06-25 | 3 | 3 | glyceraldehyde-3-phosphate; cofactor specificity; protein engineering; cofactor imbalance; Corynebacterium glutamicum | LYSINE PRODUCTION; PATHWAY; MECHANISM; CRYSTAL; GENOME | cofactor imbalance; cofactor specificity; Corynebacterium glutamicum; glyceraldehyde-3-phosphate; protein engineering | Corynebacterium glutamicum; Glyceraldehyde-3-Phosphate Dehydrogenases; NAD; NADP; Prospective Studies; Protein Engineering; Biochemical engineering; Enzyme activity; Genetic engineering; glyceraldehyde 3 phosphate dehydrogenase; nicotinamide adenine dinucleotide; nicotinamide adenine dinucleotide phosphate; Biobased chemicals; Cofactor imbalance; Cofactor specificity; Cofactors; Corynebacterium glutamicum; Crystals structures; Glyceraldehyde-3-phosphate; Glyceraldehyde-3-phosphate dehydrogenase; L-glutamate; Protein engineering; Corynebacterium glutamicum; genetics; metabolism; prospective study; protein engineering; Crystal structure | English | 2023 | 2023-11-07 | 10.1021/acs.jafc.3c06176 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | CO-Induced TTP Activation Alleviates Cellular Senescence and Age-Dependent Hepatic Steatosis via Downregulation of PAI-1 | Aging can increase the risk of various hepatic diseases, especially non-alcoholic fatty liver disease (NAFLD). Although the mechanisms underlying the pathogenesis of age-related disorders such as NAFLD remain incompletely understood, recent studies have implicated the accumulation of senescent cells as a contributing factor. Here, we show that tristetraprolin (TTP) deficiency accelerates NAFLD during aging by enhancing the senescence-associated secretory phenotype (SASP) as well as several hallmarks of senescence. The sequestration of plasminogen activator inhibitor (PAI)-1, a mediator of cellular senescence, in stress granules, (SGs) inhibits cellular senescence. In our previous report, we have shown that carbon monoxide (CO), a small gaseous mediator, can induce the assembly of SGs via an integrated stress response. Here, we show that CO treatment promotes the assembly of SGs which can sequester PAI-1, resulting in the inhibition of etoposide (ETO)-induced cellular senescence. Notably, CO-induced TTP activation enhances PAI-1 degradation, leading to protection against ETO-induced cellular senescence. CO-dependent Sirt1 activation promotes the inclusion of TTP into SGs, leading to decreased PAI-1 levels. Therefore, our findings highlight the importance of TTP as a therapeutic target in age-related NAFLD and offer a potential new strategy to reduce the detrimental effects of senescent cells in hepatic disorders. | Park, Jeongmin; Chen, Yingqing; Kim, Jeongha; Hwang, Eunyeong; Park, Gyu Hwan; Yang, Chae Ha; Ryter, Stefan W.; Park, Jeong Woo; Chung, Hun Taeg; Joe, Yeonsoo | Univ Ulsan, Sch Biol Sci, Ulsan 44610, South Korea; Dalian Univ, Med Coll, Dept Pharmacol, Dalian, Peoples R China; Daegu Haany Univ, Coll Korean Med, Daegu 42158, South Korea; Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Daegu, South Korea; Proterris Inc, Boston, MA 02118 USA | 49763812900; 55961777500; 58309325600; 58257732200; 9939639300; 8904920600; 6602484026; 56540123400; 7404006898; 55114313900 | chung@ulsan.ac.kr;jcantibody@ulsan.ac.kr; | AGING AND DISEASE | AGING DIS | 2152-5250 | 14 | 2 | SCIE | GERIATRICS & GERONTOLOGY | 2023 | 7 | 7.4 | 1.67 | 2025-06-25 | 9 | 8 | aging; carbon monoxide; cellular senescence; non-alcoholic fatty liver diseases (NAFLD); stress granules; PAI-1; Sirt1; tristetraprolin | ESTER-INDUCED HYPERTENSION; DOUBLE-STRAND BREAKS; PROTEIN-KINASE; DNA-DAMAGE; INHIBITOR-1; STRESS; TRISTETRAPROLIN; INDUCTION; GRANULES; GENE | aging; carbon monoxide; cellular senescence; non-alcoholic fatty liver diseases (NAFLD); PAI-1; Sirt1; stress granules; tristetraprolin | alanine aminotransferase; aspartate aminotransferase; carbon monoxide; etoposide; interleukin 1beta; interleukin 6; plasminogen activator inhibitor 1; protein p16; protein p21; sirtuin 1; small interfering RNA; topotecan; triacylglycerol; tristetraprolin; tumor necrosis factor; AML12 cell line; animal cell; animal experiment; animal model; Article; bicinchoninic acid assay; cell aging; chemiluminescence immunoassay; controlled study; down regulation; drug distribution; enzyme activity; enzyme linked immunosorbent assay; fatty liver; female; fibroblast; genetic transfection; HEK293 cell line; hepatic damage assay; human; human cell; immunofluorescence assay; immunohistochemistry; Kruskal Wallis test; liver cell; liver dysfunction; liver tissue; luciferase assay; male; MEF cell line; mouse; mRNA expression level; nonalcoholic fatty liver; nonhuman; real time polymerase chain reaction; reverse transcription polymerase chain reaction; RNA isolation; senescence; senescence associated beta galactosidase staining; senescence-associated secretory phenotype; stress granule; Western blotting; WI-38 cell line | English | 2023 | 2023-04 | 10.14336/ad.2023.0120 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Downstream changes in floodplain sedimentation and their effects on channel avulsion in stream-dominated alluvial fans: The Cretaceous Duwon Formation in the southern Korean Peninsula | Stream-dominated alluvial fans are formed by the periodic channel avulsion running on their surfaces and are characterized by the downstream changes in hydrodynamics of stream flows and flood frequency. The spatial variations in hydrodynamics also control the sedimentation on the floodplain, which is important for sediment dispersal patterns on the stream-dominated alluvial fans as they feed back into channel avulsion processes. To understand the influence of downstream changes in hydrodynamics on the floodplain sedimentation and associated channel avulsion processes, we studied the Cretaceous Duwon Formation in the southern part of the Korean Peninsula. The Duwon Formation unconformably overlies the Paleoproterozoic basements and consists of gravelly braided stream deposits (FA-1), sandy braided stream deposits (FA-2), and calcretes-bearing flood -plain deposits (FA-3). Close to the basements, FA-1 shows the radial paleoflow patterns, and the size of sediments and the ratio of channel to floodplain deposits decrease downstream over a relatively short distance (<7 km). This indicates that the Duwon Formation was deposited in the stream-dominated alluvial fans under arid to semi-arid climatic conditions, which can be classified into the proximal, medial, and distal zones.In the medial zone, the floodplain deposits are composed of the underlying, purple-colored sandstones and the overlying, compensational stacked crevasse channel and splay deposits (ca. 19 m thick) with the unsystematic paleoflow directions, finally overlain by the sandy braided stream deposits. In contrast, in the distal zone, the floodplain fines are composed of homogeneous clay and silt with calcretes and vegetation traces. These flood -plain fines are interbedded with and overlain by the progradational stacked, coarsening-and thickening -upward trending, crevasse channel and splay deposits (ca. 18 m thick) with the constant paleoflow directions to those of the overlying sandy braided stream deposits. In the medial zone, a relatively large volume of discharge of the stream floods resulted in the frequent overbank flooding via the multiple breaching points and the con-comitant growth of alluvial ridges by the combined effects of in-channel bed aggradation and compensational stacked crevasse channel and splay deposits resulted in a shift in the flow pathway of the sandy braided streams. In the distal zone, the floodplain fines containing calcretes and vegetation traces suggest the longer periods of non-deposition, providing sufficient time for the vegetation development. Once the channel levees collapsed, the vegetated channel levees stabilized the breaching point, and the breaching point progressively incised by the multiple flooding events, causing susceptibility to overbank flooding. Crevasse channel flows via the breaching point and associated overbank floodwaters led to a continuous supply of the coarse-grained sediments stacking on the cohesive, vegetated floodplain fines, with an increase in the cross-floodplain topographic gradient. As a result, crevasse channels were able to advance the distal floodplains, resulting in the development of progradational stacking pattern. With the cross-floodplain topographic gradient, the deposition of these erodible overbank flooding sediments on the cohesive, vegetated floodplain fines provided an alternative route for the parent channel, resulting in channel avulsion. Thus, this study suggests that downstream changes in hydrodynamics and associated floodplain sedimentation are important for channel avulsion and hence control the sediment dispersal patterns of coarse-grained sediments on the stream-dominated alluvial fans.(c) 2023 Published by Elsevier B.V. | Lee, Kyungjin; Gihm, Yong Sik | Kyungpook Natl Univ, Dept Geol, Daegu 41556, South Korea | 57277784000; 56025805300 | naress@knu.ac.kr; | SEDIMENTARY GEOLOGY | SEDIMENT GEOL | 0037-0738 | 1879-0968 | 456 | SCIE | GEOLOGY | 2023 | 2.7 | 7.4 | 0.86 | 2025-06-25 | 4 | 4 | Hydrodynamics; Compensational stacking pattern; Progradational stacking pattern; Crevasse channel and splay deposits; Alluvial ridge growth | DISTRIBUTIVE FLUVIAL SYSTEM; WILLIAMS FORK FORMATION; KICKING-HORSE-RIVER; U-PB AGES; KYONGSANG BASIN; JINDONG FORMATION; GYEONGSANG BASIN; FACIES ARCHITECTURE; NORTHWESTERN PART; PICEANCE BASIN | Alluvial ridge growth; Compensational stacking pattern; Crevasse channel and splay deposits; Hydrodynamics; Progradational stacking pattern | Korea; Banks (bodies of water); Buildings; Deposits; Erosion; Floods; Hydrodynamics; Ostwald ripening; Rivers; Sedimentation; Sedimentology; Sediments; Stream flow; Alluvial ridge growth; Channel avulsions; Compensational stacking; Compensational stacking pattern; Crevasse channel and splay deposit; Down-stream; Flood plains; Progradational stacking pattern; Stacking patterns; alluvial fan; avulsion; braided river; channel morphology; Cretaceous; crevasse; floodplain; hydrodynamics; overbank sediment; sediment transport; sedimentation; semiarid region; streamflow; topographic effect; Coarsening | English | 2023 | 2023-10 | 10.1016/j.sedgeo.2023.106473 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Loss of ACO4 in petunia improves abiotic stress tolerance by reducing the deleterious effects of stress-induced ethylene | To investigate the role of ethylene (ET) in abiotic stress tolerance in petunia cv. 'Mirage Rose', petunia plants in which the ET biosynthesis gene 1-aminocyclopropane-1-carboxylic acid oxidase 4 (ACO4) was knocked out (phaco4 mutants) and wild-type (WT) plants were exposed to heat and drought conditions. Loss of function of ACO4 significantly delayed leaf senescence and chlorosis under heat and drought stress by maintaining the SPAD values and the relative water content, indicating a greater stress tolerance of phaco4 mutants than that of WT plants. This tolerance was related to the lower ET and reactive oxygen species levels in the mutants than in WT plants. Furthermore, the stress-induced expression of genes related to ET signal transduction, antioxidant and proline activities, heat response, and biosynthesis of abscisic acid was higher in the mutants than in WT plants, indicating a greater stress tolerance in the former than in the latter. These results demonstrate the deleterious effects of stress-induced ET on plant growth and provide a better physiological and molecular understanding of the role of stress ET in the abiotic stress response of petunia. Because the loss of function of ACO4 in petunia improved stress tolerance, we suggest that ACO4 plays a vital role in stress-induced leaf senescence and acts as a negative regulator of abiotic stress tolerance. | Naing, Aung Htay; Baek, Sangcheol; Campol, Jova Riza; Kang, Hyunhee; Kim, Chang Kil | Kyungpook Natl Univ, Dept Hort Sci, Daegu 41566, South Korea | Naing, Aung Htay/AAF-4277-2019 | 37112768100; 58562307500; 57486378900; 57217681910; 7409880701 | ckkim@knu.ac.kr; | PLANT PHYSIOLOGY AND BIOCHEMISTRY | PLANT PHYSIOL BIOCH | 0981-9428 | 1873-2690 | 203 | SCIE | PLANT SCIENCES | 2023 | 6.1 | 7.4 | 0.16 | 2025-06-25 | 1 | 1 | Ethylene; Gene expression; Leaf senescence; Mutants; Reactive oxygen species; SPAD | CREEPING BENTGRASS; LEAF SENESCENCE; HEAT TOLERANCE; SALT-TOLERANCE; BIOSYNTHESIS; EXPRESSION; GENE; ACCUMULATION; RESPONSES; DROUGHT | Ethylene; Gene expression; Leaf senescence; Mutants; Reactive oxygen species; SPAD | English | 2023 | 2023-10 | 10.1016/j.plaphy.2023.107998 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Pantoea conspicua promoted sunflower growth and engulfed rhizospheric arsenate by secreting exopolysaccharide | A rhizobacterium, Pantoea conspicua, was examined against sunflower seedlings' growth under arsenate stress. Sunflower upon exposure to arsenate resulted in compromised growth that might be due to the accumulation of higher concentrations of arsenate and reactive oxygen species (ROS) in seedlings' tissues. The deposited arsenate led to oxidative damage and electrolyte leakage, making the sunflower seedlings vulnerable to compromise its growth and development. However, inoculation of sunflower seedlings with P. conspicua alleviated arsenate stress in host by initiating a multilayered defence mechanism. In fact, P. conspicua filtered out 75.1% of the arsenate from growth medium that were available to the plant roots in the absence of the said strain. To accomplish such activity, P. conspicua secreted exopolysaccharides as well as altered lignification in host roots. The arsenate (24.9%) that made its way to plant tissues was countered by helping the host seedlings to produce higher levels of indole acetic acid, non enzymatic antioxidants (phenolics and flavonoids) and antioxidant en-zymes (catalase, ascorbte peroxidase, peroxidase, superoxide dismutase). As a result, ROS accumulation and electrolyte leakage were brought back to normal levels as observed in control seedlings. Hence, the rhizo-bacterium associated host seedlings achieved higher net assimilation (127.7%) and relative growth rate (113.5%) under 100 ppm of arsenate stress. The work concluded that P. conspicua alleviated arsenate stress in the host plants by imposing physical barrier as well as improving host seedlings' physiology and biochemistry. | Qadir, Muhammad; Hussain, Anwar; Shah, Mohib; Hamayun, Muhammad; Iqbal, Amjad; Irshad, Muhammad; Khan, Zafar Hayat; Islam, Badshah; Elansary, Hosam O.; Mahmoud, Eman A.; Lee, In -Jung | Abdul Wali Khan Univ, Dept Bot, Garden Campus, Mardan, Khyber Pakhtunk, Pakistan; Abdul Wali Khan Univ, Dept Food Sci & Technol, Garden Campus, Mardan, Khyber Pakhtunk, Pakistan; Abdul Wali Khan Univ, Dept Agron, Garden Campus, Mardan, Khyber Pakhtunk, Pakistan; Abdul Wali Khan Univ, Dept Hort, Garden Campus, Mardan, Khyber Pakhtunk, Pakistan; King Saud Univ, Coll Food & Agr Sci, Plant Prod Dept, POB 2455, Riyadh 11451, Saudi Arabia; Damietta Univ, Fac Agr, Dept Food Ind, Dumyat 34511, Egypt; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 702701, South Korea | Hussain, Anwar/N-1605-2019; Qadir, Muhammad/AFJ-3919-2022; Elansary, Hosam/E-3684-2019; Hamayun, Muhammad/B-1694-2010; Mahmoud, Prof. Eman/AAK-9113-2021; Khan, Zafar/GVT-3259-2022; Iqbal, Amjad/E-2010-2014; Lee, In-Jung/GLS-0432-2022; Irshad, Muhammad/JQW-6402-2023 | 57210988627; 35621772200; 56433799400; 59297330100; 10142205100; 57206301341; 56204722000; 57191855372; 35388049900; 56327094100; 16425830900 | drhussain@awkum.edu.pk;helansary@ksu.edu.sa;emanmail2005@yahoo.com; | PLANT PHYSIOLOGY AND BIOCHEMISTRY | PLANT PHYSIOL BIOCH | 0981-9428 | 1873-2690 | 201 | SCIE | PLANT SCIENCES | 2023 | 6.1 | 7.4 | 1.87 | 2025-06-25 | 11 | 12 | PGPR; Bioremediation; Arsenic uptake; Exopolysaccharide; Improved antioxidant system | GLUTATHIONE-REDUCTASE; RAPID-DETERMINATION; ORYZA-SATIVA; RESPONSES; PURIFICATION; TOXICITY; BACTERIA; STRESS; ENZYME; ROOTS | Arsenic uptake; Bioremediation; Exopolysaccharide; Improved antioxidant system; PGPR | Antioxidants; Arsenates; Helianthus; Oxidative Stress; Pantoea conspicua; Plant Roots; Reactive Oxygen Species; Seedlings; Superoxide Dismutase; antioxidant; arsenic acid; arsenic acid derivative; reactive oxygen metabolite; superoxide dismutase; metabolism; oxidative stress; plant root; seedling; sunflower | English | 2023 | 2023-08 | 10.1016/j.plaphy.2023.107826 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A genomic estimated breeding value-assisted reduction method of single nucleotide polymorphism sets: a novel approach for determining the cutoff thresholds in genome-wide association studies and best linear unbiased prediction | Traditionally, the p-value is the criterion for the cutoff threshold to determine significant markers in genome-wide association studies (GWASs). Choosing the best subset of markers for the best linear unbiased prediction (BLUP) for improved prediction ability (PA) has become an interesting issue. However, when dealing with many traits having the same marker information, the p-values' themselves cannot be used as an obvious solution for having a confidence in GWAS and BLUP. We thus suggest a genomic estimated breeding value-assisted reduction method of the single nucleotide polymorphism (SNP) set (GARS) to address these difficulties. GARS is a BLUP-based SNP set decision presentation. The samples were Landrace pigs and the traits used were back fat thickness (BF) and daily weight gain (DWG). The prediction abilities (PAs) for BF and DWG for the entire SNP set were 0.8 and 0.8, respectively. By using the correlation between genomic estimated breeding values (GEBVs) and phenotypic values, selecting the cutoff threshold in GWAS and the best SNP subsets in BLUP was plausible as defined by GARS method. 6,000 SNPs in BF and 4,000 SNPs in DWG were considered as adequate thresholds. Gene Ontology (GO) analysis using the GARS results of the BF indicated neuron projection development as the notable GO term, whereas for the DWG, the main GO terms were nervous system development and cell adhesion. | Lee, Young-Sup; Oh, Jae-Don; Lee, Jun-Yeong; Shin, Donghyun | Jeonbuk Natl Univ, Dept Anim Biotechnol, Jeonju, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Jeonbuk Natl Univ, Dept Agr Convergence Technol, Jeonju 54896, South Korea | 57203692244; 7402155301; 56428518900; 56591172300 | sdh1214@gmail.com; | ANIMAL CELLS AND SYSTEMS | ANIM CELLS SYST | 1976-8354 | 2151-2485 | 27 | 1 | SCIE | CELL BIOLOGY;ZOOLOGY | 2023 | 2.5 | 7.5 | 0.2 | 2025-06-25 | 0 | 1 | Correlation difference (CD); genomic estimated breeding value (GEBV)-assisted reduction method of SNP set (GARS); landrace pigs; prediction ability (PA) | BACKFAT THICKNESS; PORK QUALITY; LANDRACE; GWAS | Correlation difference (CD); genomic estimated breeding value (GEBV)-assisted reduction method of SNP set (GARS); landrace pigs; prediction ability (PA) | English | 2023 | 2023-12-11 | 10.1080/19768354.2023.2250841 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects of metaverse-based career mentoring for nursing students: a mixed methods study | BackgroundThere is a lack of studies on metaverse-based career mentoring for college students in both quantitative and qualitative research. This study aimed to examine the effect of metaverse-based career mentoring among nursing students and explore the experiences of mentors and mentees.MethodsThis study used a mixed methods design using both a survey for collecting quantitative data and focus group interviews for a qualitative one. A total of 8 mentors and 43 mentees participated in the metaverse-based career mentoring program. The program covered eight career fields and was delivered across eight sessions of 60 min each, over six days. Career decision-making self-efficacy among mentees and platform and program satisfaction were measured before and after the program. Afterwards, 7 mentors and 12 mentees participated in the focus group interviews to investigate their experience of participating in the metaverse-based career mentoring program. Quantitative data were analyzed using descriptive statistics, paired t-test, Wilcoxon signed-rank test, and Mann-Whitney U test. The qualitative data underwent thematic analysis.ResultsAfter the metaverse-based career mentoring program, mentees' career decision-making self-efficacy increased significantly compared to the baseline level. From the mentor-mentee focus group interviews, three key themes were derived: (i) communicating frankly and openly, (ii) being satisfied with realistic communication and program functions, and (iii) expecting an even more optimized program.ConclusionsA metaverse-based career mentoring program for nursing students can have a positive effect on their career decision-making self-efficacy. In addition, in terms of education, it is helpful as a non-face-to-face medium and feeling a sense of reality, so it is expected that it will be beneficial in education by applying various contents in the future. | Kim, Yujeong; Kim, Mi Young | Kyungpook Natl Univ, Res Inst Nursing Sci, Coll Nursing, Daegu, South Korea; Hanyang Univ, Coll Nursing, Seoul, South Korea | 57200941945; 57069194800 | miyoung0@hanyang.ac.kr; | BMC NURSING | BMC NURS | 1472-6955 | 22 | 1 | SCIE;SSCI | NURSING | 2023 | 3.1 | 7.5 | 2.87 | 2025-06-25 | 9 | 10 | Career Choice; Mentoring; Virtual reality; Self-efficacy; Nursing students | EMOTIONAL INTELLIGENCE; DECISION-MAKING; MEDIATING ROLE; EXPLORATION; EFFICACY | Career Choice; Mentoring; Nursing students; Self-efficacy; Virtual reality | article; controlled study; decision making; education; human; human experiment; interview; mentor; mentoring; nursing student; quantitative analysis; rank sum test; satisfaction; self concept; thematic analysis; virtual reality; Wilcoxon signed ranks test | English | 2023 | 2023-05-15 | 10.1186/s12912-023-01323-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Inhibition of ubiquitin specific peptidase 14 (USP14) promotes ER-phagy by inducing ER stress in human hepatoma HepG2 cells | Autophagy plays a critical role in regulating the quality and quantity of cellular compartments; however, the mechanisms governing endoplasmic reticulum (ER) autophagy (ER-phagy) are still largely undefined. In this study, we identified several inhibitors of USP14, a ubiquitin-specific protease, including IU1 and b-AP15, as novel ER-phagy inducers through chemical library screening. While USP14 is known to act as an ER stress inducer, its precise role in ER-phagy remains unclear. Our findings demonstrate that treatment with either IU1 or b-AP15 induces ER-phagy by increasing ER stress in HepG2 cells. Similarly, depletion of USP14 augments ER-phagy and the ER stress response. The blockage of autophagy using an ULK1 inhibitor, SBI0206965, impedes ER-phagy. Moreover, inhibition of ER stress with tauroursodeoxycholic acid reverses ER-phagy by alleviating ER stress in HepG2 cells. We also found that suppression of the stress kinase JNK inhibited ER-phagy in IU1-treated cells. In conclusion, the results of this study suggest that the inhibition of USP14 accelerates ER-phagy by enhancing ER stress and JNK activation in HepG2 cells. | Kim, Joon Bum; Bae, Ji-Eun; Park, Na Yeon; Jo, Doo Sin; Kim, Yong Hwan; Jeong, Kwiwan; Kim, Pansoo; Lee, Won-Ha; Yeom, Eunbyul; Cho, Dong-Hyung | Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat BioRes Grp BK21, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; ORGASIS Corp, Suwon 16229, South Korea; Bioind Dept, Gyeonggido Business & Sci Accelerator, Suwon, South Korea; Kyungpook Natl Univ, Sch Life Sci, 80 Daehakro, Daegu 41566, South Korea | Kim, Joon/ADP-8066-2022; Choi, Hye Rin/JDV-9065-2023 | 57190611030; 57190605352; 57190609826; 56335489800; 57204676401; 57197993212; 59548676400; 57205609794; 56058004100; 35093684400 | dhcho@knu.ac.kr; | ANIMAL CELLS AND SYSTEMS | ANIM CELLS SYST | 1976-8354 | 2151-2485 | 27 | 1 | SCIE | CELL BIOLOGY;ZOOLOGY | 2023 | 2.5 | 7.5 | 0.2 | 2025-06-25 | 1 | 1 | ER-phagy; USP14; IU1; b-AP15; ER stress | ENDOPLASMIC-RETICULUM TURNOVER; DEUBIQUITINATING ACTIVITY; AUTOPHAGY; PROTEASOME; RECEPTOR; PHOSPHORYLATION; PROTEIN; P53 | b-AP15; ER stress; ER-phagy; IU1; USP14 | English | 2023 | 2023-12-11 | 10.1080/19768354.2023.2285825 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Liquid crystalline elastomer actuators with dynamic covalent bonding: Synthesis, alignment, reprogrammability, and self-healing | Liquid crystalline elastomers (LCEs) have demonstrated tremendous potential in applications such as soft robotics, biomedical materials, electronics, sensors, and biomimetic systems. The physical properties of LCEs are controlled by the degree of crosslinking, nature of the mesogens, and mesogen orientation in the LCE network structure. A wide range of dynamic covalent bonds (DCBs) capable of dynamic bond exchange reactions (DBERs) have been introduced into LCE structures to obtain intelligent materials in recent decades. In this review article, we discuss the molecular constitution, macrostructure, morphing mechanism, recent advances in LCEs with dynamic covalent bonds, the influence of DCBs on self-healing, reprogramming and reprocessing properties of LCE actuators, and challenges and opportunities in incorporating dynamic chemistry in the field of LCE actuators. | Das, Gautam; Park, Soo-Young | Kyungpook Natl Univ, Sch Appl Chem Engn, Polymer Nanomat Lab, Daegu 41566, South Korea | park, soo-young/N-3170-2017 | 24358918500; 57194041850 | psy@knu.ac.kr; | CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE | CURR OPIN SOLID ST M | 1359-0286 | 1879-0348 | 27 | 3 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2023 | 12.2 | 7.5 | 0.72 | 2025-06-25 | 19 | 19 | Liquid crystalline elastomer; Dynamic covalent bonding; Actuators; Self-healing; Reprogrammability | POLYMER NETWORKS; VISIBLE-LIGHT; MECHANICAL-PROPERTIES; ARTIFICIAL MUSCLES; EPOXY NETWORKS; POLYURETHANE; SOFT; BEHAVIOR; MONODOMAIN; EXCHANGE | Actuators; Dynamic covalent bonding; Liquid crystalline elastomer; Reprogrammability; Self-healing | Biomimetic materials; Biomimetics; Covalent bonds; Crosslinking; Elastomers; Electroactive polymer actuators; Functional polymers; Plastics; Self-healing materials; Biomedical material; Covalent bonding; Dynamic covalent bonding; Electronic sensors; Liquid crystalline elastomers; Material systems; Mesogens; Re-programmability; Self-healing; Soft robotics; Dynamics | English | 2023 | 2023-06 | 10.1016/j.cossms.2023.101076 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Mitochondrial genome-based synthesis and timeline of Eurasian otter (Lutra lutra) phylogeography | Eurasian otters (Lutra lutra) have a broad distribution across Eurasia, but biogeographic data outside of western Europe is limited to disconnected pockets. Based on current subspecies designations, Asia appears to harbour a large proportion of the species' diversity, with 10 of 12 Eurasian otter subspecies found in Asia. Here we provide a range-wide synthesis of mitochondrial data, inferring a timeline and pattern of phylogeographic signals. Whole mitochondrial genomes of 27 Eurasian otters across 4 subspecies are presented from newly generated data (n = 6; 4 from Korea, 1 from Hong Kong and 2 from UK), assembled from the Sequence Read Archive (n = 4), and sourced from GenBank (n = 17). We then combined whole mitochondrial genome results with cytochrome b data to increase the sample size and contextualise our results with prior studies. We identified five distinct lineages that were discordant with current subspecies classification. Phylogenetic dating revealed that the earliest diverging lineage was the Japanese lineage, with remaining lineages diverging >= 0.08 million years ago. Mitochondrial diversity calculated by sample locations seemed mainly driven by the presence of multiple lineages. When grouping samples by lineage, genetic diversity was highest in Lineage 1 (primarily found in China and Laos), followed by Lineage 2 (primarily found in Korea), and lowest diversity identified in Lineage 3 (primarily found in Europe). Our findings highlight previously undetected lineage diversity within Eurasian otters, but also the need for further taxonomic and genomic evaluation of the species in Asia. The identified unique, distinct lineages of Eurasian otters also warrant urgent conservation attention. | du Plessis, Sarah J.; Hong, Sungwon; Lee, Boyoung; Koepfli, Klaus-Peter; Chadwick, Elizabeth A.; Hailer, Frank | Cardiff Univ, Sch Biosci Organisms & Environm, Cardiff, Wales; Kyungpook Natl Univ, Dept Horse Compan & Wild Anim Sci, Sangju, South Korea; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju, South Korea; George Mason Univ, Smithsonian Mason Sch Conservat, Front Royal, VA USA; Smithsonians Natl Zoo & Conservat Biol Inst, Ctr Species Survival, Washington, DC USA; Kyungpook Natl Univ, Dept Horse Compan & Wild Anim Sci, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea | Hailer, Frank/C-9114-2012; Koepfli, Klaus-Peter/AAT-9320-2020; Chadwick, Elizabeth/G-1793-2010; du Plessis, Sarah/JXN-9041-2024 | 58399968600; 56431586600; 58723032100; 6506265169; 8901887100; 12646402700 | shong@knu.ac.kr; | ANIMAL CELLS AND SYSTEMS | ANIM CELLS SYST | 1976-8354 | 2151-2485 | 27 | 1 | SCIE | CELL BIOLOGY;ZOOLOGY | 2023 | 2.5 | 7.5 | 1.02 | 2025-06-25 | 5 | 5 | Biogeography; cytochrome b; mitochondrial genome; phylogeography; subspecies | TAXONOMIC STATUS; CARNIVORA; POPULATION; MUSTELIDAE; PATTERNS; MAFFT | Biogeography; cytochrome b; mitochondrial genome; phylogeography; subspecies | English | 2023 | 2023-12-11 | 10.1080/19768354.2023.2283763 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | NAA10 Hypomethylation is associated with particulate matter exposure and worse prognosis for patients with non-small cell lung cancer | Airborne particulate matter (PM) is a major health hazard worldwide and is a key factor in lung cancer, which remains the most common type of malignancy and the leading cause of cancer-related deaths. DNA methylation is a critical mechanism underlying the detrimental effects of PM, however, the molecular link between PM exposure and lung cancer remains to be elucidated. N-a-acetyltransferase 10 (NAA10) is involved in the cell cycle, migration, apoptosis, differentiation, and proliferation. In order to investigate the role of NAA10 in PM-induced pathogenesis processes leading to lung cancer, we determined the expression and methylation of NAA10 in normal human bronchial epithelial (NHBE) cells treated with PM10, PM10-polycyclic aromatic hydrocarbons (PAH), and PM2.5 and evaluated the prognostic value of the NAA10 methylation status in lung cancer patients. Exposure to all PM types significantly increased the expression of NAA10 mRNA and decreased the methylation of the NAA10 promoter in NHBE cells compared with the mock-treated control. NAA10 hypomethylation was observed in 9.3% (13/140) of lung cancer tissue samples and correlated with NAA10 transcriptional upregulation. Univariate and multivariate analyses revealed that NAA10 hypomethylation was associated with decreased survival of patients with lung cancer. Therefore, these results suggest that PM-induced hypomethylation of the NAA10 may play an important role in the pathogenesis of lung cancer and may be used as a potential prognostic biomarker for lung cancer progression. Further studies with large numbers of patients are warranted to confirm our findings. | Lee, Ji Yun; Lee, Su Man; Lee, Won Kee; Park, Jae Yong; Kim, Dong Sun | BK21 Plus Biomed Convergence Program, Dept Anat, Daegu, South Korea; Hanyang Univ, Dept Grad Sch Biomed Sci & Engn, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea | Kim, Dae/AAJ-7518-2021 | 37124481700; 59631205000; 22953484700; 58360293800; 58378868400 | doskim@knu.ac.kr;jaeyong@knu.ac.kr; | ANIMAL CELLS AND SYSTEMS | ANIM CELLS SYST | 1976-8354 | 2151-2485 | 27 | 1 | SCIE | CELL BIOLOGY;ZOOLOGY | 2023 | 2.5 | 7.5 | 1.43 | 2025-06-25 | 7 | 7 | Particulate matter; human bronchial epithelial cells; lung cancer; DNA methylation; N-alpha-acetyltransferase 10 | BRONCHIAL EPITHELIAL-CELLS; AIR-POLLUTION; DNA METHYLATION; TRANSCRIPTOME; METHYLOME; RISK | DNA methylation; human bronchial epithelial cells; lung cancer; N-α-acetyltransferase 10; Particulate matter | English | 2023 | 2023-12-11 | 10.1080/19768354.2023.2189934 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Suppressive effects of (-)-tubaic acid on RANKL-induced osteoclast differentiation and bone resorption | Regulation of osteoclastogenesis and bone-resorbing activity can be an efficacious strategy for treating bone loss diseases because excessive osteoclastic bone resorption leads to the development of such diseases. Here, we investigated the role of (-)-tubaic acid, a thermal degradation product of rotenone, in osteoclast formation and function in an attempt to identify alternative natural compounds. (-)-Tubaic acid significantly inhibited receptor activator of nuclear factor-kappa B ligand (RANKL)-mediated osteoclast differentiation at both the early and late stages, suggesting that (-)-tubaic acid affects the commitment and differentiation of osteoclast progenitors as well as the cell-cell fusion of mononuclear osteoclasts. (-)-Tubaic acid attenuated the activation of extracellular signal-regulated kinase (ERK) and expression of nuclear factor of activated T-cells cytoplasmic 1 (NFATc1) and its target genes in response to RANKL. Furthermore, a pit-formation assay revealed that (-)-tubaic acid significantly impaired the bone-resorbing activity of osteoclasts. Our results demonstrated that (-)-tubaic acid exhibits anti-osteoclastogenic and anti-resorptive effects, indicating its therapeutic potential in the management of osteoclast-related bone diseases. | Lim, Soomin; Ihn, Hye Jung; Kim, Ju Ang; Bae, Jong-Sup; Kim, Jung-Eun; Bae, Yong Chul; Shin, Hong-In; Kim, Tae Hoon; Park, Eui Kyun | Kyungpook Natl Univ, Sch Dent, Dept Oral Pathol & Regenerat Med, IHBR, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst CMRI, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, CMRI, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, CMRI, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Anat & Neurobiol, Daegu, South Korea; Daegu Univ, Dept Food Sci & Biotechnol, Gyongsan, South Korea | Bae, Jong-Sup/AAU-9724-2020; Kim, Ju Ang/LWI-0914-2024 | 57202647759; 56421724400; 55991948000; 16021543200; 57209054588; 56377838800; 24377179200; 56906394500; 37071072400 | skyey7@daegu.ac.kr;epark@knu.ac.kr; | ANIMAL CELLS AND SYSTEMS | ANIM CELLS SYST | 1976-8354 | 2151-2485 | 27 | 1 | SCIE | CELL BIOLOGY;ZOOLOGY | 2023 | 2.5 | 7.5 | 0.41 | 2025-06-25 | 2 | 2 | (-)-tubaic acid; osteoclast; bone resorption; nuclear factor of activated T-cells cytoplasmic 1 (NFATc1) | RECEPTOR ACTIVATOR; FUSION; LIGAND; BENZOFURAN; INHIBITORS; KINASE; POTENT | (-)-tubaic acid; bone resorption; nuclear factor of activated T-cells cytoplasmic 1 (NFATc1); osteoclast | English | 2023 | 2023-12-11 | 10.1080/19768354.2023.2166107 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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