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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Photoinduced radical polymerization by methyl fluoresceins under visible light and the application to signal amplification of hydrogen peroxide | We investigate visible-light-induced radical polymerization initiated by methyl fluorescein and its derivatives (e.g., methyl ether of fluorescein, methyl ether ester of fluorescein, and methyl ester of fluorescein), which act as photoredox catalysts. The structural alterations of fluorescein noticeably affect their photoredox catalytic performance, which increases in the following order: methyl ether of fluorescein < methyl ether ester of fluorescein < methyl ester of fluorescein <= fluorescein. Particularly, the methylation on the phenolic hydroxyl group reduces their performance mainly due to the restraint of tautomerization. Based on this systematic investigation, we synthesize methyl ether fluorescein, bearing aryl boronate as an H2O2-selective photoredox catalyst and use it to amplify the signal of H2O2 through the photoinduced radical polymerization. In the presence of H2O2, this photoredox catalyst successfully initiates the polymerization of poly(ethylene glycol) diacrylate and N-vinyl-pyrrolidone, forming a polymeric hydrogel in 1 min under visible-light irradiation. For the naked-eye detection of H2O2, 10 mu M of the catalyst allows a successful detection of H2O2 down to 20 mu M. We envision that our strategy will be highlighted by mechanistic elucidation of photoredox catalysis and synthesis of multifunctional photoredox catalysts. Other benefits include biomedical applications such as colorimetric sensing of a target analyte, cell surface engineering, and cell therapy. | Nganga, Joseph B.; Jung, Young Jae; Si, Yunpei; Kim, Minyoung; Ko, Hyebin; Hwang, Gil Tae; Lee, Hye Jin; Lee, Hong-In; Lee, Jungkyu K. | Kyungpook Natl Univ, Dept Chem, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Greennano Mat Res Ctr, 80 Daehak Ro, Daegu 41566, South Korea | ; Hwang, Gil Tae/L-6502-2017; Lee, Hong-In/IXN-3185-2023 | 57226016306; 57211604984; 57203850418; 57223366791; 57444872900; 7202676087; 56569175200; 8509535000; 8312040000 | jkl@knu.ac.kr; | DYES AND PIGMENTS | DYES PIGMENTS | 0143-7208 | 1873-3743 | 200 | SCIE | CHEMISTRY, APPLIED;ENGINEERING, CHEMICAL;MATERIALS SCIENCE, TEXTILES | 2022 | 4.5 | 9.6 | 0.54 | 2025-06-25 | 8 | 7 | Polymerization-based amplification; Naked-eye detection; Photoinduced radical polymerization; Stimulus-selective turn-on photoredox catalyst | PHOTOPOLYMERIZATION; SURFACES; COATINGS | Naked-eye detection; Photoinduced radical polymerization; Polymerization-based amplification; Stimulus-selective turn-on photoredox catalyst | Alkylation; Catalysts; Detection; Esters; Ethers; Light; Performance; Polymerization; Alkylation; Atom transfer radical polymerization; Cell engineering; Cell membranes; Esters; Ethers; Eye protection; Light; Medical applications; Polyethylene glycols; Detection of H; Methyl esters; Methyl ethers; Naked-eye detection; Photoinduced radical polymerization; Polymerization-based amplification; Signal amplifications; Stimulus-selective turn-on photoredox catalyst; Visible light; ]+ catalyst; Catalysts | English | 2022 | 2022-04 | 10.1016/j.dyepig.2022.110163 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Preparation of blue and green fluorescent dyes based on thioxanthone and phenothiazine derivatives and their thermal-stability, quantum yield properties | Eight dyes were synthesized to connect carbazole or naphthalimidinyl groups with a thioxanthone central ring utilizing an acetylene bond. In this series of fluorescent dyes, a nitrogen atom of both carbazole and naphthalimidyl rings were substituted by an n-butyl or phenyl group to use as a dye intermediate, then coupled to the central ring in the final step. Eight dyes prepared were identified using by H-1 NMR, GC-Mass and elemental analyses. Main properties, such as the absorption maxima, emission maxima, molar extinction coefficient and thermal stabilities by TGA analysis of the fluorescent dyes prepared were examined. To optimize the structure of the dye molecules, calculations using a Density Functional Theory (DFT) and Time-Dependent DFT were performed for some dyes. In terms of absorption and emission maxima, six dyes from this series exhibited blue fluorescent emission those in the range of 443-457 nm, whereas two dyes substituted by either N-n-butyl-naphthalimide, or N-phenyl-naphthalimide group were red-shifted comparing to those of six dyes providing a green emission of 520 nm or 525 nm. The quantum yields for six dyes substituted by either N-n-Butyl-carbazole or N-phenyl-carbazole group were higher than those of analogous two dyes containing a naphthalimde group where all of six dyes exhibited 0.81-0.87 these were efficient compared to previous research. | Kang, E-J; Lee, Y-G; Choi, J-H | Kyungpook Natl Univ, Dept Text Syst Engn, Daegu 41566, South Korea | 57846605200; 57845931400; 56175157400 | jaehong@knu.ac.kr; | DYES AND PIGMENTS | DYES PIGMENTS | 0143-7208 | 1873-3743 | 206 | SCIE | CHEMISTRY, APPLIED;ENGINEERING, CHEMICAL;MATERIALS SCIENCE, TEXTILES | 2022 | 4.5 | 9.6 | 0.23 | 2025-06-25 | 2 | 3 | Thermal stability; Quantum yield; Naphthalimide; Thioxanthone; Phenothiazine | Naphthalimide; Phenothiazine; Quantum yield; Thermal stability; Thioxanthone | Absorption; Emission; Fluorescence; Fluorescent Dyes; Insecticides; Maxima; Rings; Stability; Density functional theory; Fluorescence; Insecticides; Polycyclic aromatic hydrocarbons; Red Shift; Thermodynamic stability; Absorption maxima; Emission maxima; Fluorescent dyes; Naphthalimide; Nitrogen atom; Phenothiazine; Phenothiazine derivatives; Synthesised; Thioxanthones; Yield properties; Quantum yield | English | 2022 | 2022-10 | 10.1016/j.dyepig.2022.110594 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Deacetylation kinetics of promising energy crops, hemp and kenaf, for cellulosic ethanol production | Lignocellulosic hydrolysates contain acetic acid derived from hemicellulose. Acetate released during acid pretreatment interferes with enzymatic saccharification of the biomass and inhibits yeast fermentation, caused by cellular oxidation and stress. This study used alkaline deacetylation prior to acid pretreatment and evaluated its influence on the fermentation performance of Saccharomyces cerevisiae using two different lignocellulosic biomasses, hemp (Cannabis sativa) and kenaf (Hibiscus cannabinus). They are valuable for biofuel production. The maximal acetate removal with minimal sugar loss was obtained with 1% (w/v) NaOH treatment for both biomasses. Deacetylation pretreatment under this condition was effective both in enzymatic saccharification and simultaneous saccharification and fermentation. This resulted in improved ethanol production by xylose-consuming yeast (S. cerevisiae SR8) by removing 4.7 g/L of acetate from hemp and 6.3 g/L from kenaf, thus resulting in the ethanol productivities of 0.79 and 0.67 g/L-h from hemp and kenaf, respectively. This suggests that strategies to overcome acetate inhibition are necessary to efficiently use the lignocellulosic biomass as a source for bioenergy production. | Ju, Yebin; Kim, In Jung; Kim, Suhyeung; Olawuyi, Ibukunoluwa Fola; Kim, Kyung-Min; Kim, Soo Rin | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu, South Korea | Kim, Soo Rin/X-2192-2019; Kim, Kyung-Min Kim/C-7007-2014; Olawuyi, Ibukunoluwa/H-1232-2018; kim, nayoung/IWV-4038-2023 | 57221630545; 57195531808; 57860897000; 57204471854; 34868260300; 36659584200 | kkm@knu.ac.kr;soorinkim@knu.ac.kr; | GLOBAL CHANGE BIOLOGY BIOENERGY | GCB BIOENERGY | 1757-1693 | 1757-1707 | 14 | 11 | SCIE | AGRONOMY;ENERGY & FUELS | 2022 | 5.6 | 9.7 | 0.53 | 2025-06-25 | 8 | 6 | acetic acid; cellulosic ethanol; hemp; kenaf; lignocellulosic biomass; Saccharomyces cerevisiae; xylose fermentation | HIBISCUS-CANNABINUS-L.; ACETIC-ACID; INDUSTRIAL HEMP; SACCHAROMYCES-CEREVISIAE; FERMENTATION; PRETREATMENT; BIOREFINERY; DEGRADATION; COMPOSITES; INHIBITORS | acetic acid; cellulosic ethanol; hemp; kenaf; lignocellulosic biomass; Saccharomyces cerevisiae; xylose fermentation | Acetic Acid; Biomass; Ethanol; Farm Crops; Fermentation; Ph; Acetic acid; Bioethanol; Biomass; Cellulosic ethanol; Crops; Ethanol; Fermentation; pH; Saccharification; Sodium hydroxide; Yeast; Acid pretreatment; Bio-energy; Deacetylation; Energy crops; Enzymatic saccharification; Ethanol production; Kenaf; Lignocellulosic biomass; Lignocellulosic hydrolysates; Xylose fermentation; acetic acid; biomass; crop production; energy crop; ethanol; fermentation; inhibition; reaction kinetics; Hemp | English | 2022 | 2022-11 | 10.1111/gcbb.12992 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice | Post-stroke vascular remodeling, including angiogenesis, facilitates functional recovery. Proper vascular repair is important for efficient post-stroke recovery; however, the underlying mechanisms coordinating the diverse signaling pathways involved in vascular remodeling remain largely unknown. Recently, axon guidance molecules were revealed as key players in injured vessel remodeling. One such molecule, Semaphorin 3E (Sema3E), and its receptor, Plexin-D1, control vascular development by regulating vascular endothelial growth factor (VEGF) signaling. In this study, using a mouse model of transient brain infarction, we aimed to investigate whether Sema3E-Plexin-D1 signaling was involved in cerebrovascular remodeling after ischemic injury. We found that ischemic damage rapidly induced Sema3e expression in the neurons of peri-infarct regions, followed by Plexin-D1 upregulation in remodeling vessels. Interestingly, Plexin-D1 reemergence was concurrent with brain vessels entering an active angiogenic process. In line with this, Plxnd1 ablation worsened neurological deficits, infarct volume, neuronal survival rate, and blood flow recovery. Furthermore, reduced and abnormal vascular morphogenesis was caused by aberrantly increased VEGF signaling. In Plxnd1 knockout mice, we observed significant extravasation of intravenously administered tracers in the brain parenchyma, junctional protein downregulation, and mislocalization in regenerating vessels. This suggested that the absence of Sema3E-Plexin-D1 signaling is associated with blood-brain barrier (BBB) impairment. Finally, the abnormal behavioral performance, aberrant vascular phenotype, and BBB breakdown defects in Plxnd1 knockout mice were restored following the inhibition of VEGF signaling during vascular remodeling. These findings demonstrate that Sema3E-Plexin-D1 signaling can promote functional recovery by downregulating VEGF signaling in the injured adult brain. | Yu, Ri; Kim, Nam-Suk; Li, Yan; Jeong, Jin-Young; Park, Sang-Joon; Zhou, Bin; Oh, Won-Jong | Korea Brain Res Inst, Neurovasc Biol Lab, Neurovasc Unit, Res Grp, Daegu 41062, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Dept Brain & Cognit Sci, Daegu 42988, South Korea; Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China | 55620701300; 54385382300; 57221624611; 57223332926; 7501825941; 57891872700; 8588864800 | ohwj@kbri.re.kr; | TRANSLATIONAL STROKE RESEARCH | TRANSL STROKE RES | 1868-4483 | 1868-601X | 13 | 1 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2022 | 6.9 | 9.7 | 2.09 | 2025-06-25 | 19 | 19 | Plexin-D1; Axon guidance; Stroke; Vascular recovery; Blood– brain barrier | ENDOTHELIAL GROWTH-FACTOR; MIDDLE CEREBRAL-ARTERY; BRAIN-BARRIER BREAKDOWN; NEUROVASCULAR INJURY; ISCHEMIC-STROKE; GENE-EXPRESSION; SEMAPHORIN 3E; ANGIOGENESIS; MECHANISMS; INHIBITION | Axon guidance; Blood–brain barrier; Plexin-D1; Stroke; Vascular recovery | Animals; Cell Adhesion Molecules; Cell Adhesion Molecules, Neuronal; Down-Regulation; Infarction; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Mice; Nerve Tissue Proteins; Semaphorins; Stroke; Vascular Endothelial Growth Factor A; Vascular Remodeling; claudin 5; occludin; plexin; protein ZO1; semaphorin; semaphorin 3E; semaxanib; tracer; unclassified drug; vasculotropin; cell adhesion molecule; membrane protein; nerve cell adhesion molecule; nerve protein; plexin; Plxnd1 protein, mouse; Sema3e protein, mouse; semaphorin; signal peptide; vasculotropin A; angiogenesis; animal experiment; animal model; animal tissue; Article; axon guidance; binding assay; blood brain barrier; blood flow; blood vessel density; body weight loss; brain blood vessel; brain damage; brain infarction; brain ischemia; cerebrovascular accident; controlled study; down regulation; endothelium cell; extravasation; infarct volume; knockout mouse; lesion volume; male; molecular weight; mouse; mouse model; nonhuman; parenchyma; phenotype; protein expression; protein function; protein phosphorylation; remission; survival rate; T2 weighted imaging; upregulation; vascular remodeling; vascularization; VEGF signaling; animal; down regulation; genetics; infarction; metabolism; vascular remodeling | English | 2022 | 2022-02 | 10.1007/s12975-021-00914-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Editing of 1-aminocyclopropane-1-carboxylate oxidase genes negatively affects petunia seed germination | Key message Editing of ACO genes involved in ethylene biosynthesis pathway reduces ethylene production in petunia seeds and inhibits seed germination. Ethylene production in the seeds of Petunia hybrida cv. 'Mirage Rose' was associated with expression of 1-aminocyclopropane-1-carboxylic acid (ACC) oxidase (ACO) genes (PhACO1, PhACO3, and PhACO4). Suppression of their expression by ethylene inhibitor silver thiosulphate (STS) significantly reduced ethylene production and inhibited seed germination. When it was combined with ethylene precursor ACC, ethylene production was re-promoted via activation of the genes and higher seed germination was restored. This was confirmed using the mutants editing the genes and WT. In the present study, compared with wild type plants, three different mutants (phaco1, phaco3, and phaco4) showed significantly decreased germination percentages as well as delayed germination time and seedling growth. These reductions were associated with lighter seed weight, lower ACO transcript levels, and lower ethylene production in mutants. Inhibited seed germination owing to reduced ethylene production was further verified by the supplementation of exogenous ACC and gibberellic acid (GA(3)) to growth medium, which restored high seed germination activity in all mutants via enhanced ethylene production. In this study, we reported a key regulatory role of ethylene in seed germination mechanisms in petunia. Further, we highlighted on need to consider the negative effects of ethylene reduction in seed germination and plant growth when editing genes in the ethylene biosynthesis pathway for the maintenance of postharvest fruit, vegetable, and flower quality. | Naing, Aung Htay; Xu, Junping; Kim, Chang Kil | Kyungpook Natl Univ, Dept Hort, Daegu 41566, South Korea; Natl Inst Hort & Herbal Sci, Floriculture Res Div, Rural Dev Adm, Wonju 55365, South Korea | Naing, Aung Htay/AAF-4277-2019 | 37112768100; 56677024300; 7409880701 | ckkim@knu.ac.kr; | PLANT CELL REPORTS | PLANT CELL REP | 0721-7714 | 1432-203X | 41 | 1 | SCIE | PLANT SCIENCES | 2022 | 6.2 | 9.8 | 1.68 | 2025-06-25 | 14 | 15 | 1-Aminocyclopropane-1-carboxylic acid; Ethylene production; Gibberellic acid; Gene expression; Seedling growth | TOPS BRASSICA-RAPA; ABSCISIC-ACID; ETHYLENE PRODUCTION; FINAL STEP; OXIDASE; EXPRESSION; L.; BIOSYNTHESIS; DORMANCY; ACC | 1-Aminocyclopropane-1-carboxylic acid; Ethylene production; Gene expression; Gibberellic acid; Seedling growth | Amino Acid Oxidoreductases; Ethylenes; Gene Editing; Germination; Petunia; Plant Proteins; Seeds; 1-aminocyclopropane-1-carboxylic acid oxidase; ethylene; ethylene derivative; oxidoreductase; plant protein; enzymology; gene editing; genetics; germination; metabolism; Petunia; physiology; plant seed | English | 2022 | 2022-01 | 10.1007/s00299-021-02802-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | On W²,p-estimates for solutions of obstacle problems for fully nonlinear elliptic equations with oblique boundary conditions | This paper concerns fully nonlinear elliptic obstacle problems with oblique boundary conditions. We investigate the existence, uniqueness and W-2,W-p-regularity results by finding approximate non-obstacle problems with the same oblique boundary condition and then making a suitable limiting process. | Byun, Sun-Sig; Han, Jeongmin; Oh, Jehan | Seoul Natl Univ, Dept Math Sci, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Math, Seoul 08826, South Korea; Univ Jyvaskyla, Dept Math & Stat, Jyvaskyla 40014, Finland; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea | 8350569400; 57211057723; 56673305300 | byun@snu.ac.kr;jehan@jyu.fi;jehan.oh@knu.ac.kr; | CALCULUS OF VARIATIONS AND PARTIAL DIFFERENTIAL EQUATIONS | CALC VAR PARTIAL DIF | 0944-2669 | 1432-0835 | 61 | 5 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2022 | 2.1 | 9.8 | 0.68 | 2025-06-25 | 3 | 4 | DERIVATIVE PROBLEMS; REGULARITY | English | 2022 | 2022-10 | 10.1007/s00526-022-02259-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Overexpression of acdS gene encoding 1-aminocyclopropane-1-carboxylic acid deaminase enzyme in petunia negatively affects seed germination | Key message Overexpression ofacdSin petunia negatively affects seed germination by suppression of ethylene biosynthesis and signaling genes and induction of abscisic acid biosynthesis genes in the seeds. The acdS gene, which encodes 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase, has been overexpressed in horticultural crops to improve their tolerance to abiotic stress. However, the role of acdS in the germination of crop seeds has not been investigated, despite its suppression of ethylene production. In this study, acdS overexpression significantly reduced seed weight and germination rate in transgenic petunia cv. Merage Rose (T5, T7, and T12) relative to wild type via the suppression of ethylene biosynthesis and signaling genes and induction of abscisic acid (ABA) biosynthesis genes. The germination rate of T7 was significantly lower than those of T5 and T12, which was linked to higher expression of acdS in the former than the latter. The addition of exogenous ACC and gibberellic acid (GA(3)) to the germination medium improved the germination rate of T5 seeds and GA(3) promoted the germination rate of T12 seeds. However, neither ACC nor GA(3) promoted the germination rate of T7 seeds. The improved germination rates in T5 and T12 were associated with the transcriptional regulation of ethylene biosynthesis genes, particularly that of the ACO1 gene, signaling genes, and ABA biosynthesis genes. In this study, we discovered a negative role of acdS in seed germination in petunia. Thus, we highlight the need to consider the negative effect of acdS on seed germination when overexpressing the gene in horticultural crops to improve tolerance to abiotic stress. | Naing, Aung Htay; Campol, Jova Riza; Jeong, Hui Yeong; Chung, Mi Young; Kim, Won-Chan; Kim, Chang Kil | Kyungpook Natl Univ, Dept Hort Sci, Daegu, South Korea; NIFoS, Forest Med Resources Res Ctr, Yeongju, South Korea; Sunchon Natl Univ, Dept Agr Educ, Sunchon, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea | KIM, WON/AAJ-4506-2020; Naing, Aung Htay/AAF-4277-2019 | 37112768100; 57486378900; 57218898962; 24821361600; 55492085000; 7409880701 | ckkim@knu.ac.kr; | PLANT CELL REPORTS | PLANT CELL REP | 0721-7714 | 1432-203X | 41 | 11 | SCIE | PLANT SCIENCES | 2022 | 6.2 | 9.8 | 0.22 | 2025-06-25 | 2 | 2 | 1-Aminocyclopropane-1-carboxylic acid; Gibberellic acid; Gene expression; Seed weight; Seed germination | TOPS BRASSICA-RAPA; ABSCISIC-ACID; ETHYLENE BIOSYNTHESIS; ACC DEAMINASE; FINAL STEP; EXPRESSION; DORMANCY; GIBBERELLINS; PEA; OXIDASE | 1-Aminocyclopropane-1-carboxylic acid; Gene expression; Gibberellic acid; Seed germination; Seed weight | Abscisic Acid; Ethylenes; Gene Expression Regulation, Plant; Germination; Petunia; Seeds; 1-aminocyclopropane-1-carboxylic acid; abscisic acid; ethylene derivative; gene expression regulation; genetics; germination; metabolism; Petunia; plant seed | English | 2022 | 2022-11 | 10.1007/s00299-022-02916-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Anti-angiogenesis revisited: reshaping the treatment landscape of advanced non-small cell lung cancer | Although anti-angiogenic agents have been of limited use in the treatment of non-small cell lung cancer (NSCLC) until recently, further roles for the use of angiogenesis inhibition have emerged in the era of targeted therapy and immune checkpoint blockade. Given the shared common downstream signals of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) with their complementary roles in tumorigenesis and tumor angiogenesis, the dual inhibition of EGFR and VEGF pathways represents a rational strategy to maximize clinical efficacy and overcome resistance in the treatment of EGFR-mutant NSCLC. VEGF-driven angiogenesis is a potent driver of immunosuppressive tumor microenvironment (TME), with the recruited immunosuppressive cells driving angiogenesis, highlighting the interplay between the tumor vasculature and the anticancer immunity. Anti-angiogenic therapy can normalize the tumor vasculature and reprogram the TME from immunosuppressive into immunosupportive. Intensive research is under way to utilize the anti-angiogenic combination therapy to its full potential in diverse clinical settings in urgent unmet needs for the treatment of NSCLC. In this review, we present an overview of tumor angiogenesis and summarize the scientific background and preclinical and clinical evidence of anti-angiogenic therapy in combination with target therapy and immunotherapy for the treatment of NSCLC. | Choi, Sun Ha; Yoo, Seung Soo; Lee, Shin Yup; Park, Jae Yong | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Lung Canc Ctr, Chilgok Hosp, Daegu 41404, South Korea; Kyungpook Natl Univ, Vessel Organ Interact Res Ctr, Daegu 41566, South Korea | Choi, Sun Ha/HPD-7234-2023 | 57199723585; 56479781600; 49863712700; 58360293800 | shinyup@knu.ac.kr; | ARCHIVES OF PHARMACAL RESEARCH | ARCH PHARM RES | 0253-6269 | 1976-3786 | 45 | 4 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2022 | 6.7 | 9.9 | 0.82 | 2025-06-25 | 21 | 20 | Angiogenesis; Anti-angiogenic therapy; Combination; Targeted therapy; Immunotherapy | ENDOTHELIAL GROWTH-FACTOR; FACTOR RECEPTOR EGFR; PHASE-III TRIAL; TUMOR ANGIOGENESIS; VESSEL NORMALIZATION; PLUS BEVACIZUMAB; 1ST-LINE THERAPY; DOUBLE-BLIND; T-CELLS; IN-VIVO | Angiogenesis; Anti-angiogenic therapy; Combination; Immunotherapy; Targeted therapy | Angiogenesis Inhibitors; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Humans; Immunotherapy; Lung Neoplasms; Neovascularization, Pathologic; Tumor Microenvironment; Vascular Endothelial Growth Factor A; afatinib; angiopoietin; angiopoietin receptor; bevacizumab; catequentinib; cytotoxic T lymphocyte antigen 4; epidermal growth factor receptor; epidermal growth factor receptor kinase inhibitor; erlotinib; fibroblast growth factor 2; gefitinib; hypoxia inducible factor 1; immune checkpoint inhibitor; intercellular adhesion molecule 1; interleukin 8; nintedanib; osimertinib; placental growth factor; platelet derived growth factor; programmed death 1 receptor; ramucirumab; rivoceranib; transforming growth factor beta; vascular cell adhesion molecule 1; vasculotropin; angiogenesis inhibitor; vasculotropin A; antiangiogenic therapy; cancer combination chemotherapy; cancer immunotherapy; carcinogenesis; CD8+ T lymphocyte; cytotoxic T lymphocyte; drug efficacy; drug safety; EGFR signaling; extracellular matrix; hypertension; hypoxia; immunoregulation; molecularly targeted therapy; non small cell lung cancer; overall response rate; overall survival; progression free survival; protein expression; proteinuria; Review; tumor immunity; tumor microenvironment; tumor vascularization; tumor-associated macrophage; human; immunotherapy; lung tumor; metabolism; neovascularization (pathology) | English | 2022 | 2022-04 | 10.1007/s12272-022-01382-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Assessment of artificial neural network to identify compositional differences in ultrahigh-resolution mass spectra acquired from coal mine affected soils | This study assessed the applicability of artificial neural networks (ANNs) as a tool to identify compounds contributing to compositional differences in coal-contaminated soils. An artificial neural network model was constructed from laser desorption ionization ultrahigh-resolution mass spectra obtained from coal contaminated soils. A good correlation (R-2 = 1.00 for model and R-2 = 0.99 for test) was observed between the measured and predicted values, thus validating the constructed model. To identify chemicals contributing to the coal contents of the soils, the weight values of the constructed model were evaluated. Condensed hydrocarbon and low oxygen containing compounds were found to have larger weight values and hence they were the main contributors to the coal contents of soils. In contrast, compounds identified as lignin did not contribute to the coal contents of soils. These findings were consistent with the conventional knowledge on coal and results from the conventional partial least square method. Therefore, we concluded that the weight interpretation following ANN analysis presented herein can be used to identify compounds that contribute to the compositional differences of natural organic matter (NOM) samples. | Solihat, Nissa Nurfajrin; Son, Seungwoo; Williams, Elizabeth K.; Ricker, Matthew C.; Plante, Alain F.; Kim, Sunghwan | Natl Res & Innovat Agcy BRIN, Res Ctr Biomat, Cibinong 16911, Indonesia; Kyungpook Natl Univ, Dept Chem, 80 Daehak Ro, Daegu 41566, South Korea; Univ Penn, Philadelphia, PA 19104 USA; North Carolina State Univ, Raleigh, NC USA; Mass Spectrometry Convergence Res Ctr, Daegu 41566, South Korea; Green Nano Mat Res Ctr, Daegu 41566, South Korea | ; Plante, Alain/C-3498-2008; Kim, Sunghwan/HKN-9812-2023; Solihat, Nissa/GVT-7174-2022 | 57199653322; 57206473214; 56447684400; 23767682300; 7003888675; 57203772967 | sunghwank@knu.ac.kr; | TALANTA | TALANTA | 0039-9140 | 1873-3573 | 248 | SCIE | CHEMISTRY, ANALYTICAL | 2022 | 6.1 | 9.9 | 0.69 | 2025-06-25 | 9 | 10 | Natural organic matter; Weight; FT-ICR MS; Neural network; Soil | DISSOLVED ORGANIC-MATTER; PARTIAL LEAST-SQUARES; FT-ICR-MS; VARIABLE SELECTION; CRUDE-OIL; SPECTROMETRY; PREDICTION; NUMBERS; CARBON | FT-ICR MS; Natural organic matter; Neural network; Soil; Weight | Coal; Desorption; Mass Spectra; Mass Spectrometers; Organic Compounds; Weight; Coal; Environmental Monitoring; Mass Spectrometry; Neural Networks, Computer; Soil; Soil Pollutants; Coal; Coal mines; Desorption; Least squares approximations; Mass spectrometers; Mass spectrometry; Organic compounds; Soil pollution; Soils; coal; Coal content; Compositional difference; Contaminated soils; FT-ICR MS; Mass spectra; Natural organic matters; Neural-networks; Ultrahigh resolution; Weight; Weight values; chemistry; environmental monitoring; mass spectrometry; soil; soil pollutant; Neural networks | English | 2022 | 2022-10-01 | 10.1016/j.talanta.2022.123623 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Crosstalk between angiogenesis and immune regulation in the tumor microenvironment | Cancer creates a complex tumor microenvironment (TME) composed of immune cells, stromal cells, blood vessels, and various other cellular and extracellular elements. It is essential for the development of anti-cancer combination therapies to understand and overcome this high heterogeneity and complexity as well as the dynamic interactions between them within the TME. Recent treatment strategies incorporating immune-checkpoint inhibitors and anti-angiogenic agents have brought many changes and advances in clinical cancer treatment. However, there are still challenges for immune suppressive tumors, which are characterized by a lack of T cell infiltration and treatment resistance. In this review, we will investigate the crosstalk between immunity and angiogenesis in the TME. In addition, we will look at strategies designed to enhance anti-cancer immunity, to convert "immune suppressive tumors" into "immune activating tumors," and the mechanisms by which these strategies enhance effector immune cell infiltration. | Kim, Hei Jung; Ji, Young Rae; Lee, You Mie | Kyungpook Natl Univ, Vessel Organ Interact Res Ctr, VOICE MRC, 80 Daehak Ro, Daegu 41566, South Korea; Natl Inst Deafness & Other Commun Disorders, NIH, Bethesda, MD USA; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Dept Mol Pathophysiol, 80 Daehak Ro, Daegu 41566, South Korea | ; Ji, Youngrae/AAK-9724-2021; Lee, Kyung-Soo/C-9016-2011 | 24461681100; 59290241700; 8230508600 | lym@knu.ac.kr; | ARCHIVES OF PHARMACAL RESEARCH | ARCH PHARM RES | 0253-6269 | 1976-3786 | 45 | 6 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2022 | 6.7 | 9.9 | 2.57 | 2025-06-25 | 62 | 63 | Tumor microenvironment; Angiogenesis; Immune suppressive tumor; Tumor-associated macrophage; Treg cells | ENDOTHELIAL GROWTH-FACTOR; CD8(+) T-CELLS; HYPOXIA-INDUCIBLE FACTORS; NATURAL-KILLER-CELLS; SUPPRESSOR-CELLS; DENDRITIC CELLS; NK CELLS; B-CELLS; PERIPHERAL-BLOOD; VESSEL NORMALIZATION | Angiogenesis; Immune suppressive tumor; Treg cells; Tumor microenvironment; Tumor-associated macrophage | Humans; Neoplasms; Tumor Microenvironment; angiogenesis; cell infiltration; human; human cell; immunocompetent cell; immunoregulation; regulatory T lymphocyte; review; T lymphocyte; tumor immunity; tumor microenvironment; tumor-associated macrophage; neoplasm; pathology; physiology | English | 2022 | 2022-06 | 10.1007/s12272-022-01389-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Enhanced bioavailability and hepatoprotective effect of silymarin by preparing silymarin-loaded solid dispersion formulation using freeze-drying method | This study aimed to develop a solid dispersion formulation of silymarin (Silymarin-SD) using freeze-drying method to enhance its oral bioavailability (BA) by inhibiting the intestinal first-pass effect and increasing its solubility and permeability. Silymarin-SD formulation (i.e., silymarin:tween 80:hydroxypropyl cellulose (HPC) = 1:1:3 (w/w/w) significantly increased silymarin permeability in the duodenum, jejunum, and ileum by decreasing the efflux ratio of silymarin and by inhibiting silymarin-glucuronidation activity, in which tween 80 played a crucial role. As a result, orally administered Silymarin-SD formulation increased plasma silymarin concentrations and decreased silymarin-glucuronide in rats compared with silymarin alone and silymmarin:d-alpha-tocopherol polyethylene glycol 1000 succinate (1:1, w/w) formulation. In addition to modulating intestinal first-pass effect, Silymarin-SD formulation showed a significantly higher cumulative dissolution for 120 min compared with that of silymarin from the physical mixture (PM) of the same composition as Silymarin-SD and silymarin alone; the relative BA of silymarin-SD increased to 215% and 589% compared with silymarin-PM and silymarin alone, respectively. This could be attributed to the amorphous status of the Silymarin-SD formulation without chemical interaction with excipients, such as tween 80 and HPC. Moreover, the hepatoprotective effect of Silymarin-SD in acetaminophen-induced acute hepatotoxicity, as estimated from the alanine aminotransferase and aspartate aminotransferase values, was superior to that of silymarin. In conclusion, the increase in the dissolution rate and intestinal permeability of silymarin, and the inhibition of silymarin-glucuronidation by the Silymarin-SD formulation, prepared using tween 80 and HPC, increased its plasma concentration and resulted in a superior hepatoprotective effect compared to silymarin. | Lim, Dong Yu; Pang, Minyeong; Lee, Jaehyeok; Lee, Jihoon; Jeon, Ji-Hyeon; Park, Jin-Hyang; Choi, Min-Koo; Song, Im-Sook | Dankook Univ, Coll Pharm, Cheonan 31116, South Korea; Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr VOICE, Res Inst Pharmaceut Sci,BK21 FOUR Community Based, Daegu 41566, South Korea | 57219057824; 57488599500; 57219980183; 57195979045; 57204685946; 57267338300; 8695781400; 7201564500 | minkoochoi@dankook.ac.kr;isssong@knu.ac.kr; | ARCHIVES OF PHARMACAL RESEARCH | ARCH PHARM RES | 0253-6269 | 1976-3786 | 45 | 10 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2022 | 6.7 | 9.9 | 1.48 | 2025-06-25 | 15 | 15 | Silymarin; Solid dispersion formulation; Tween 80; Intestinal first-pass effect; Relative bioavailability; Hepatoprotective effect | PHARMACOKINETICS; ABSORPTION; FLAVONOLIGNANS; NANOPARTICLES; DISSOLUTION; PERMEATION; SOLUBILITY; PROTECTION; SILIBININ; PLASMA | Hepatoprotective effect; Intestinal first-pass effect; Relative bioavailability; Silymarin; Solid dispersion formulation; Tween 80 | alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; polysorbate 80; silymarin; animal experiment; animal tissue; Article; bioavailability; blood sampling; controlled study; differential scanning calorimetry; dispersion; drug metabolism; Fourier transform infrared spectroscopy; freeze drying; high performance liquid chromatography; histopathology; liquid chromatography-mass spectrometry; liver protection; liver toxicity; male; nonhuman; pharmacokinetics; rat; scanning electron microscopy; solid dispersion; thermography; urea blood level; X ray diffraction | English | 2022 | 2022-10 | 10.1007/s12272-022-01407-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Isothermal amplification-mediated lateral flow biosensors for in vitro diagnosis of gastric cancer-related microRNAs | MicroRNAs (miRNAs) are important diagnostic and prognostic biomarkers for various tumors. Currently, many diagnostic systems have been developed to detect miRNAs, but simple techniques for detecting miRNAs are still required. Recently, we reported that the expression of miRNA-135b is upregulated in gastric epithelial cells during gastric inflammation and carcinogenesis. Our aim was to develop an in vitro diagnostic platform to analyze the expression of gastric cancer-related biomarkers in the blood. The diagnostic platform comprised an isothermal amplification-based lateral flow biosensor (IA-LFB) that enables easy diagnosis of gastric cancer through visual observation. In this platform, trace amounts of biomarkers are isothermally amplified through rolling circle amplification (RCA), and the amplified product is grafted to the LFB. The performance of the IA-LFB was confirmed using RNAs extracted from in vitro and in vivo models. The platform could detect target miRNAs within 3 h with excellent sensitivity and selectivity. In particular, the IA-LFB could detect the overexpression of gastric cancer-related markers (miRNA-135b and miRNA-21) in RNAs extracted from the blood of patients with various stages (stages 1-4) of gastric cancer compared to that in healthy volunteers. Therefore, IA-LFB is a simple and sensitive in vitro diagnostic system for detecting gastric cancer-related biomarkers and can contribute to the early diagnosis and prognosis monitoring of gastric cancer. Furthermore, this technology can be applied to systems that can detect multiple biomarkers related to various diseases (such as infectious and genetic diseases). | Seo, Seung Beom; Hwang, Jin-Seong; Kim, Eunjung; Kim, Kyujung; Roh, Seokbeom; Lee, Gyudo; Lim, Jaewoo; Kang, Byunghoon; Jang, Soojin; Son, Seong Uk; Kang, Taejoon; Jung, Juyeon; Kim, Jang-Seong; Keun-Hur; Han, Tae-Su; Lim, Eun-Kyung | Bionanotechnol Res Ctr, Korea Res Inst Bioscience & Biotechnol KRIBB, Daejeon 34141, South Korea; Pusan Natl Univ, Dept Cogno Mech Engn, Pusan 46241, South Korea; Biotherapeut Translat Res Ctr, KRIBB, Daejeon 34141, South Korea; Univ Sci & Technol UST, KRIBB Sch Biotechnol, Dept Funct Genom, Daejeon 34113, South Korea; Incheon Natl Univ, Dept Bioengineering Nano bioengineering, Incheon 22012, South Korea; Incheon Natl Univ, Div Bioengineering, Incheon 22012, South Korea; Korea Univ, Dept Biotechnol & Bioinformat, Sejong 30019, South Korea; Korea Univ, Interdisciplinary Grad Program Artificial Intelli, Sejong 30019, South Korea; KRIBB Sch Biotechnol, Dept Nanobiotechnol, UST, Daejeon 34113, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea | Kim, Eunjung/AAE-6382-2020; Lee, Gyudo/AHA-3183-2022; KIM, EUNJUNG/KFC-0377-2024; Kang, Taejoon/AAS-1967-2020; Lim, Eun-Kyung/AAR-8644-2020 | 57208347981; 57205178697; 36064163200; 35290573900; 57222630993; 36004836000; 57199151226; 55521413200; 57208347215; 57199167411; 12041363300; 35104985000; 7601388220; 57668822700; 26424339800; 35230166700 | tshan@kribb.re.kr;eklim1112@kribb.re.kr; | TALANTA | TALANTA | 0039-9140 | 1873-3573 | 246 | SCIE | CHEMISTRY, ANALYTICAL | 2022 | 6.1 | 9.9 | 0.97 | 2025-06-25 | 14 | 14 | Gastric cancer; microRNAs Lateral flow biosensor; Rolling circle amplification; In vitro diagnosis | BIOMARKERS; PATHWAYS | Gastric cancer; In vitro diagnosis; Lateral flow biosensor; microRNAs; Rolling circle amplification | Biosensing Techniques; Humans; MicroRNAs; Nucleic Acid Amplification Techniques; Stomach Neoplasms; Biomarkers; Biosensors; Blood; Diseases; Isotherms; Pathology; RNA; microRNA; Diagnostic systems; Flow biosensors; Gastric cancers; In vitro diagnose; In-vitro; Isothermal amplifications; Lateral Flow; Lateral flow biosensor; Rolling circle amplifications; Simple++; genetic procedures; genetics; human; nucleic acid amplification techniques; procedures; stomach tumor; Diagnosis | English | 2022 | 2022-08-15 | 10.1016/j.talanta.2022.123502 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Predictive biomarkers for molecularly targeted therapies and immunotherapies in breast cancer | Globally, breast cancer is the most common malignancy in women. Substantial efforts have been made to develop novel therapies, including targeted therapies and immunotherapies, for patients with breast cancer who do not respond to standard therapies. Consequently, new targeted therapies, such as cyclin-dependent kinase 4 and 6 inhibitors, poly (ADP-ribose) polymerase inhibitors, phosphoinositide 3-kinase inhibitor, and antibody-drug conjugates targeting human epidermal growth factor receptor 2 or trophoblast cell surface antigen-2, and immune checkpoint inhibitor targeting programmed cell death-1, have been developed and are now in clinical use. However, only some patients have benefited from these novel therapies; therefore, the identification and validation of reliable or more accurate biomarkers for predicting responses to these agents remain a major challenge. This review summarizes the currently available predictive biomarkers for breast cancer and describes recent efforts undertaken to identify potential predictive markers for molecularly targeted therapies and immune checkpoint inhibitors. | Kwon, Mi Jeong | Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea | 35278164800 | mjkwon94@knu.ac.kr; | ARCHIVES OF PHARMACAL RESEARCH | ARCH PHARM RES | 0253-6269 | 1976-3786 | 45 | 9 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2022 | 6.7 | 9.9 | 0.37 | 2025-06-25 | 9 | 9 | Breast cancer; Predictive biomarker; Molecularly targeted therapies; Immune checkpoint inhibitors | PATHOLOGICAL COMPLETE RESPONSE; TUMOR-INFILTRATING LYMPHOCYTES; EVENT-FREE SURVIVAL; PIK3CA MUTATIONS; OPEN-LABEL; PHASE-II; SACITUZUMAB GOVITECAN; HOMOLOGOUS RECOMBINATION; TRASTUZUMAB EMTANSINE; EVEROLIMUS EFFICACY | Breast cancer; Immune checkpoint inhibitors; Molecularly targeted therapies; Predictive biomarker | abemaciclib; alpelisib; biological marker; BRCA1 protein; BRCA2 protein; circulating tumor DNA; cyclin D1; cyclin dependent kinase 4; cyclin dependent kinase 4 inhibitor; cyclin dependent kinase 6 inhibitor; cyclin dependent kinase inhibitor; epidermal growth factor receptor 2; epidermal growth factor receptor antibody; estrogen receptor; everolimus; immune checkpoint inhibitor; Ki 67 antigen; lapatinib; mammalian target of rapamycin; margetuximab; messenger RNA; neratinib; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1; palbociclib; pembrolizumab; pertuzumab; phosphatidylinositol 3 kinase; phosphatidylinositol 3 kinase inhibitor; programmed death 1 receptor; retinoblastoma protein; ribociclib; sacituzumab govitecan; trastuzumab; trastuzumab deruxtecan; trastuzumab emtansine; tucatinib; unclassified drug; antigen expression; breast cancer; cancer immunotherapy; cancer prognosis; drug targeting; fluorescence in situ hybridization; gene amplification; gene overexpression; immunohistochemistry; in situ hybridization; microsatellite instability; mismatch repair; molecularly targeted therapy; prediction; protein expression; reliability; Review; treatment response; tumor associated leukocyte; tumor mutational burden | English | 2022 | 2022-09 | 10.1007/s12272-022-01402-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | S100A14: A novel negative regulator of cancer stemness and immune evasion by inhibiting STAT3-mediated programmed death-ligand 1 expression in colorectal cancer | Background Programmed death-ligand 1 (PD-L1) has functional roles in cancer stem-like cell (CSC) phenotypes and chemoresistance besides immune evasion. Chemotherapy is a common treatment choice for colorectal cancer (CRC) patients; however, chemoresistance limits its effectiveness of treatment. Methods We examined the role of S100A14 (SA14) in CRC by adopting PD-L1(high) subpopulations within CRC cell lines and patient tumours, by establishing PD-L1(high) chemoresistant CRC sublines through prolonged exposure to 5-fluorouracil/oxaliplatin-based chemotherapy in vitro and in vivo, and by analysing a public database. Results We identified a novel function of SA14 as a regulator of immune surveillance, major CSC phenotypes, and survival capacity under hostile microenvironments, including those harbouring chemotherapeutics, and as a prognostic biomarker in CRC. Mechanistically, SA14 inhibits PD-L1 expression by directly interacting with signal transducer and activator of transcription 3 (STAT3) and inducing its proteasome-mediated degradation. While gain-of-SA14 causes loss of PD-L1 expression and tumourigenic potential and sensitisation to chemotherapy-induced apoptosis in chemoresistant CRC cells, loss-of-SA14 causes increases in PD-L1 expression, tumourigenic potential, and chemoresistance in vitro and in vivo. We further show that a combinatorial treatment with chemotherapy and recombinant SA14 protein effectively induces apoptosis in PD-L1(high) chemoresistant CRC cells. Conclusions Our results suggest that SA14-based therapy is an effective strategy to prevent tumour progression and that SA14 is a predictive biomarker for anti-PD-L1 immunotherapy and chemotherapy in combination. | Min, Hye-Young; Cho, Jaebeom; Sim, Jeong Yeon; Boo, Hye-Jin; Lee, Ji-Sun; Lee, Seon-Boon; Lee, Young-Jin; Kim, Sung Joo; Kim, Kyu-Pyo; Park, In-Ja; Hong, Seung-Mo; Zhang, Xue-Li; Zhang, Zhi-Gang; Park, Rang-Woon; Lee, Ho-Young | Seoul Natl Univ, Coll Pharm, Creat Res Initiat Ctr Concurrent Control Emphysem, Seoul, South Korea; Seoul Natl Univ, Coll Pharm & Res, Inst Pharmaceut Sci, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Biochem & Cell Biol, Daegu, South Korea; Univ Ulsan, Asan Med Ctr, Dept Pathol, Coll Med, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Oncol, Coll Med, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Surg, Coll Med, Seoul, South Korea; Shanghai Jiao Tong Univ, Ren Ji Hosp, Shanghai Canc Inst, Sch Med,State Key Lab Oncoge Nes & Related Genes, Shanghai, Peoples R China | Lee, Sun-Ho/AAD-6712-2022; Park, In/U-2371-2019; LEE, Ji-Sun Lee/HTO-6715-2023; Kim, In-Ryoung/AGF-2385-2022; Zhang, Xueli/KOC-3503-2024; Kim, Sung/C-9604-2011 | hylee135@snu.ac.kr; | CLINICAL AND TRANSLATIONAL MEDICINE | CLIN TRANSL MED | 2001-1326 | 12 | 7 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL;ONCOLOGY | 2022 | 10.6 | 9.9 | 13 | cancer stem-like cells; colorectal cancer; PD-L1; STAT3 | CHECKPOINT INHIBITORS; DRUG-RESISTANCE; CHEMOTHERAPY; PROTEINS; PD-L1; TUMOR; CELLS; DIFFERENTIATION; 5-FLUOROURACIL; PERSPECTIVE | English | 2022 | 2022-07 | 10.1002/ctm2.986 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Acute and developmental toxic effects of mono-halogenated and halomethyl naphthalenes on zebrafish (Danio rerio) embryos: Cardiac malformation after 2-bromomethyl naphthalene exposure | Polyhalogenated polycyclic aromatic hydrocarbons (HPAHs) represent a major environmental concern due to their persistency and toxicity. Among them, mono-halogenated (HNs) and halomethyl naphthalenes (HMNs) are not well-studied, and the toxicity of many HNs to fishes has not been reported. In this study, we exposed zebrafish (Danio rerio) embryos to naphthalene and five HNs at concentrations ranging from 0.25 to 2.0 mg L-1 to assess acute toxicities and developmental effects. Among them, 2-bromomethyl naphthalene (2-BMN) produced moderate lethal effects (96-h LC50 = 1.4 mg L-1) and significantly reduced hatchability. Abnormal phenotypes, including pericardial edema, spine curvature, and shortened body length, were also induced by 2-BMN (96-h EC50 = 0.45 mg L-1). Treatments of 0.5-2.0 mg L-1 2-BMN evoked cardiac malformations via significant downregulation of the cacna1c gene, which codes the voltage-dependent calcium channel, at 72 hpf and up-regulation of the nppa gene, responsible for the expression of natriuretic peptides, at 96 hpf in zebrafish. One presumable toxic photo-dissociated metabolite of 2-BMN, the 2-naphthylmethyl radical, may be responsible for the toxic effect on zebrafish embryos. HPAHs must be monitored and managed due to their adverse effects on living organisms at low concentrations. | Park, Jungeun; Kim, Yurim; Jeon, Hwang-Ju; Kim, Kyeongnam; Kim, Chaeeun; Lee, Seungki; Son, Jino; Lee, Sung-Eun | Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Natl Inst Biol Resources, Biol & Genet Resources Assessment Div, Incheon 22689, South Korea | Kim, Kyeongnam/KSM-2719-2024; Jeon, Hwangju/JDW-9035-2023 | 58363479900; 57397370800; 56328792200; 57191364349; 57200245142; 57201994784; 12445463300; 55890041600 | selpess@knu.ac.kr; | ENVIRONMENTAL POLLUTION | ENVIRON POLLUT | 0269-7491 | 1873-6424 | 297 | SCIE | ENVIRONMENTAL SCIENCES | 2022 | 8.9 | 10.0 | 1.2 | 2025-06-25 | 14 | 15 | Halogenated naphthalenes; 2-Bromomethyl naphthalene; Pericardial edema; Cardiac malformation; Cacnalc and nppa genes | POLYCYCLIC AROMATIC-HYDROCARBONS; COHO SALMON FRY; POLYCHLORINATED NAPHTHALENES; REFRACTIVE-INDEX; BIPHENYLS; KINETICS; POTENCY; MINNOWS; TOLUENE; ISOMER | 2-Bromomethyl naphthalene; Cacnalc and nppa genes; Cardiac malformation; Halogenated naphthalenes; Pericardial edema | Animals; Embryo, Nonmammalian; Lethal Dose 50; Naphthalenes; Water Pollutants, Chemical; Zebrafish; Genes; Halogenation; Metabolites; Polycyclic aromatic hydrocarbons; Toxicity; 2 bromomethyl naphthalene; halomethyl naphthalene; naphthalene; natriuretic factor; unclassified drug; voltage gated calcium channel; naphthalene; naphthalene derivative; 2-bromomethyl naphthalene; Acute toxicity; Cacnalc and nppa gene; Cardiac malformation; Environmental concerns; Halogenated naphthalene; Lethal effects; Pericardial edema; Toxic effect; Zebrafish danio rerio; chemical compound; concentration (composition); cyprinid; dose-response relationship; embryo; genotoxicity; metabolite; naphthalene; PAH; pollution effect; pollution exposure; toxicity; acute toxicity; adverse outcome; Article; body height; cacna1c gene; concentration (parameter); congenital heart malformation; controlled study; developmental toxicity; down regulation; embryo; embryo development; exposure; gene; halogenation; hatchability; heart edema; LC50; nonhuman; nppa gene; pericardial edema; protein expression; spine disease; upregulation; zebra fish; animal; LD50; nonmammalian embryo; toxicity; water pollutant; zebra fish; Naphthalene | English | 2022 | 2022-03-15 | 10.1016/j.envpol.2021.118786 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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