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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Quantitative T2 Mapping Analysis With MRI of Talar Cartilage in Ankle Trauma: A Study Based on LaugeHansen Classification and Anatomical Locations | Objective: This study aimed to quantitatively assess abnormalities in the talar dome cartilage using MRI T2 mapping, with additional analyses based on the Lauge-Hansen (LH) classification and anatomical locations. Materials and Methods: This retrospective study analyzed 78 patients who underwent ankle MRI with T2 mapping for acute ankle trauma between January 2021 and October 2022. Patients were classified into the supination (S) and pronation (P) groups based on the LH classification, and then divided into subgroups based on posterior malleolus (PM) involvement. The T2 values for the talar cartilage were quantitatively measured in six anatomical regions defined by the combination of medial vs. lateral and anterior vs. central vs. posterior. The T2 mapping values in each region of the talus were compared between the S and P groups and between the PM and non-PM injury groups using t-tests. The T2 values were also compared between the medial and lateral sides within each group. Results: Among the 78 patients (mean age, 38.62 +/- 14.82 years; 47 male), 53 and 25 were in the S and P groups, respectively, and 53 patients showed PM involvement. In comparison with the P group, the S group exhibited higher T2 values in the medial portion (61.27 +/- 8.30 vs. 54.03 +/- 6.96; P < 0.001) and lower T2 values in the lateral talus (54.95 +/- 8.47 vs. 64.15 +/- 7.31; P < 0.001). The PM injury group showed higher T2 values in the posterior region than the non-PM injury group (P <= 0.011). Within the PM injury group, T2 values were higher in the anteromedial and posterolateral regions than on the opposite sides (P = 0.037 and 0.011, respectively). Conclusion: MRI T2 values demonstrated significant regional variations in the talar dome cartilage in acute ankle trauma, and the T2 values may reflect different ankle trauma mechanisms and PM involvement. Thus, T2 mapping can facilitate evaluation of talar cartilage alterations. | Khil, Eun Kyung; Cha, Jang Gyu; Kim, Sung Jae; Yoon, Yu Sung | Hallym Univ, Dongtan Sacred Heart Hosp, Dept Radiol, Hwaseong, South Korea; Soonchunhyang Univ, Coll Med, Grad Sch, Dept Radiol, Asan, South Korea; Fastbone Orthoped Hosp, Dept Radiol, Hwaseong, South Korea; Soonchunhyang Univ, Bucheon Hosp, Dept Radiol, Bucheon, South Korea; Hanyang Univ, Coll Med, Dept Orthoped Surg, Seoul, South Korea; Hanyang Univ, Guri Hosp, Dept Orthoped Surg, Foot & Ankle Div, Guri, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Radiol, Daegu, South Korea | ; Cha, Jang/U-3216-2019 | 56019764100; 59560320000; 57187257200; 57414392900 | mj4907@gmail.com; | KOREAN JOURNAL OF RADIOLOGY | KOREAN J RADIOL | 1229-6929 | 2005-8330 | 26 | 5 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2024 | 5.3 | 10.1 | N/A | 0 | 0 | Talar cartilage; T2 mapping; Magnetic resonance imaging; Lauge-Hansen classification; Posterior malleolus | LAUGE-HANSEN CLASSIFICATION; ARTICULAR-CARTILAGE; RELAXATION-TIME; INSTABILITY; ACCURACY; VALUES; JOINT | Lauge-Hansen classification; Magnetic resonance imaging; Posterior malleolus; T2 mapping; Talar cartilage | Adult; Ankle Injuries; Ankle Joint; Cartilage, Articular; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Retrospective Studies; Talus; adult; aged; anatomical location; ankle fracture; ankle injury; Article; cartilage; controlled study; emergency ward; female; human; imaging; interrater reliability; ligament injury; major clinical study; male; musculoskeletal imaging; musculoskeletal radiologist; nuclear magnetic resonance imaging; quantitative T2 mapping analysis; retrospective study; sagittal plane; talar cartilage; ankle joint; articular cartilage; diagnostic imaging; injury; middle aged; procedures; talus | English | 2025 | 2025-05 | 10.3348/kjr.2024.0773 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Multi-parameter prediction of oil palm fruit quality through near infrared spectroscopy combined with chemometric analysis | Early information concerning water, oil, and free fatty acid (FFA) content in palm fruit on-site is crucial in determining the commercial value of fresh fruit bunches (FFB) and maintaining oil palm quality. Conventional methods are destructive, labor-intensive, single-target, costly, and time-consuming. Therefore, this study aimed to develop a method for the multi-parameter prediction of oil palm fruit quality using near-infrared (NIR) spectroscopy. Empirical Wavelet Transform (EWT) and Gaussian Process Regression (GPR) were implemented as a novel chemometric method. A total of 750 fruit samples of the Tenera variety (Elaeis guineensis Jacq. var. tenera) with various maturity levels were collected from the Cikabayan Oil Palm Plantation. Each sample was scanned using an NIR instrument at 1000-1500 nm wavelengths to obtain absorbance data. The EWT was applied to decompose the NIR spectra into empirical modes, and GPR was used to build a regression model for fitting. Based on numerical analysis, the combination of EWT and GPR produced the root mean square error (RMSE) values of 2.877 f 0.900 % (R2 = 0.955 f 0.018), 1.256 f 0.543 % (R2 = 0.942 f 0.030), and 0.065 f 0.04 % (R2 = 0.964 f 0.044) for water, oil, and FFA content, respectively. The results showed that the model could accurately predict the internal quality of oil palm fruit without the need for solvents or reagents, supporting environmental sustainability. These were expected to enhance oil palm production management by improving quality control, optimizing harvest timing, and promoting sustainability across the value chain. | Nanda, Muhammad Achirul; Amaru, Kharistya; Rosalinda, S.; Novianty, Inna; Park, Tusan | Univ Padjadjaran, Fac Agroind Technol, Dept Agr & Biosyst Engn, Sumedang 45363, Indonesia; IPB Univ, Coll Vocat Studies, Comp Engn Technol Study Program, Bogor 16680, Indonesia; Kyungpook Natl Univ, Dept Smart Bioind Mech Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Smart Agr Innovat Ctr, Daegu 41566, South Korea | 57200192678; 57216288468; 57209024630; 57206896597; 57202780408 | m.achirul@unpad.ac.id; | SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | SPECTROCHIM ACTA A | 1386-1425 | 1873-3557 | 343 | SCIE | SPECTROSCOPY | 2024 | 4.6 | 10.2 | 0 | 2025-06-11 | 0 | 0 | Oil palm fruit; Quality; Near-infrared spectroscopy; Nondestructive evaluation; Chemometric | NONDESTRUCTIVE MEASUREMENT; SPECTRAL KURTOSIS | Chemometric; Near-infrared spectroscopy; Nondestructive evaluation; Oil palm fruit; Quality | Damage detection; Fourier transform infrared spectroscopy; Human resource management; Lean production; Linear regression; Logistic regression; Model predictive control; Statistical process control; Chemometrices; Gaussian process regression; Infrared: spectroscopy; Multiparameters; Near Infrared; Near-infrared; Non destructive evaluation; Oil palm fruits; Quality; Wavelets transform; Near infrared spectroscopy | English | 2025 | 2025-12-15 | 10.1016/j.saa.2025.126505 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | CREB1 controls mitochondrial dysfunction in 1-nitropyrene-mediated apoptosis of human bronchial cells and lung injury | Airborne pollutants, particularly nitro-polycyclic aromatic hydrocarbons (nitro-PAHs), are significant contributors to respiratory diseases. Among these, 1-NP, a nitro-PAH prevalent in diesel exhaust particles (DEPs), is known to induce lung damage. While studies on the respiratory toxicity of 1-NP remain limited, the underlying molecular mechanisms, particularly the roles of mitochondrial dysfunction and toxicity-related gene expression in lung cell death, are even less understood. To address this gap, this study aims to elucidate the relationship between 1-NP-induced lung cell death, mitochondrial dysfunction, and gene expression. In vitro assays were used to assess mitochondrial dysfunction and apoptotic markers in human bronchial epithelial cells, while phosphoproteomic analysis and in vivo murine models were employed to investigate the role of CREB1 phosphorylation in 1-NP toxicity. This study demonstrated an increase in apoptotic cells using Annexin V/PI staining and the activation of apoptotic proteins, such as caspase-3 and PARP, following a 24-h exposure to 1-NP. Notably, the mitochondrial cristae disruption occurred, accompanied by elevated expression of cytochrome c and Bid. Additionally, exposure of human bronchial epithelial cells to 1-NP led to significant mitochondrial dysfunction, characterized by decreased oxygen consumption rate and membrane potential, increased mitochondrial reactive oxygen species (ROS), and upregulated voltage-dependent anion channel 1 (VDAC1) expression. Phosphoproteomic analysis revealed that CREB1 phosphorylation protects against 1-NP toxicity. In contrast, CREB1 knockdown exacerbated mitochondrial respiratory disruption and apoptotic cell death, rendering cells more susceptible to 1-NP exposure. Furthermore, intranasal exposure to 1-NP in a murine model significantly elevated chemokine CCL2 levels in bronchoalveolar lavage fluid along with IL-1β and CXCL1 expression in lung tissue compared to the controls. Additionally, 1-NP exposure induced lung collapse, fibrosis, and mucin hyperexpression, along with increased expression of CREB1, cleaved caspase-3, VDAC1, and 8-OHdG, indicating oxidative DNA damage. This study demonstrates that 1-NP exposure induces CREB1 phosphorylation, mitochondrial dysfunction, cell death, and lung pathologies, highlighting the potential of this model for developing pharmaceutical interventions targeting respiratory diseases. © 2025 Elsevier B.V. | Kim, Min Jeong; Choi, Hee Jung; Kang, Ha Yeong; Kim, Hee Soo; Jung, Chang Hwa; Jung, Sung Keun | School of Food Science and Biotechnology, Kyungpook National University, South Korea; School of Food Science and Biotechnology, Kyungpook National University, South Korea; School of Food Science and Biotechnology, Kyungpook National University, South Korea; Aging and Metabolism Research Group, Korea Food Research Institute, Jeollabuk-do, Wanju-gun, 55365, South Korea, Department of Food Biotechnology, University of Science and Technology, Jeollabuk-do, Wanju-gun, 55365, South Korea; Aging and Metabolism Research Group, Korea Food Research Institute, Jeollabuk-do, Wanju-gun, 55365, South Korea, Department of Food Biotechnology, University of Science and Technology, Jeollabuk-do, Wanju-gun, 55365, South Korea; School of Food Science and Biotechnology, Kyungpook National University, South Korea, Tailored Food Technology, Kyungpook National University, Daegu, 41566, South Korea | 57215818497; 58742906900; 57733176700; 58182385800; 15834712300; 35310491400 | skjung04@knu.ac.kr; | Science of the Total Environment | SCI TOTAL ENVIRON | 0048-9697 | 1879-1026 | 968 | SCIE | ENVIRONMENTAL SCIENCES | 2024 | 8 | 10.3 | 0 | 2025-05-07 | 1 | 1-Nitropyrene; Air pollution; Apoptosis; CREB1; Lung collapse; Mitochondrial dysfunction | Air Pollutants; Animals; Apoptosis; Bronchi; Cyclic AMP Response Element-Binding Protein; Epithelial Cells; Humans; Lung Injury; Mice; Mitochondria; Pyrenes; Biological organs; Bioremediation; Glycoproteins; Lung cancer; Mitochondria; Polycyclic aromatic hydrocarbons; Pulmonary diseases; Reactive oxygen species; 1 nitropyrene; 2 (2 amino 3 methoxyphenyl)chromone; 4 (4 fluorophenyl) 2 (4 hydroxyphenyl) 5 (4 pyridyl)imidazole; aluminum hydroxide; anthra[1,9 cd]pyrazol 6(2h) one; caspase 3; CXCL1 chemokine; cyclic AMP responsive element binding protein; cytochrome c; interleukin 1beta; isoflurane; monocyte chemotactic protein 1; mucin; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1; ovalbumin; oxygen; protein Bid; reactive oxygen metabolite; voltage dependent anion channel 1; 1-nitropyrene; CREB1 protein, human; cyclic AMP responsive element binding protein; pyrene derivative; 1-nitropyrene; CREB1; Genes expression; Human bronchial epithelial cells; Lung cells; Lung collapse; Mitochondrial dysfunction; Murine model; Nitropolycyclic aromatic hydrocarbons; Phosphoproteomics; apoptosis; atmospheric pollution; cell; gene expression; injury; mitochondrion; PAH; protein; rodent; toxicity; animal experiment; animal model; animal tissue; apoptosis; Article; atelectasis; bronchial cell; bronchoalveolar lavage fluid; bronchus; cell death; cell function; cells; confocal laser scanning microscopy; controlled study; diesel particulate matter; DNA damage; electron microscopy; enzyme linked immunosorbent assay; female; flow cytometry; gene expression; histology; human; human cell; immunofluorescence; lung fibrosis; lung injury; lung parenchyma; membrane potential; mitochondrial dysfunction; mouse; MTT assay; nonhuman; oxygen consumption rate; phoproteomic; protein expression; protein phosphorylation; proteomics; toxicity; tracheotomy; transmission electron microscopy; Western blotting; air pollutant; animal; drug effect; epithelium cell; metabolism; mitochondrion; Cell death | English | Final | 2025 | 10.1016/j.scitotenv.2025.178877 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | Article | Enhancing IoMT Security Using Large Multimodal Models | This paper explores the potential of Large Multi-modal Models (LMMs) in enhancing the security of Internet of Medical Things (IoMT) networks. As IoMT systems become more complex and generate vast amounts of sensitive data, traditional security measures are increasingly insufficient to address evolving cyber threats. The ability of LMMs to process and integrate diverse data types, such as sensor data, audio, and video, offers a powerful approach to detecting and mitigating security risks in real time. By focusing on key applications like anomaly detection through traffic prediction and improving Physical Layer Security (PLS), this work demonstrates how LMMs can significantly enhance the resilience of IoMT networks against a wide range of cyber threats. The integration of multimodal data enables more accurate traffic predictions and allows adaptive responses to emerging security challenges. Additionally, LMMs contribute to strengthening PLS by identifying vulnerabilities in communication channels and optimizing resource allocation. Through dynamic data fusion techniques, LMMs ensure that IoMT systems can respond to threats in real-time, while maintaining high security and minimizing impact on system performance. © 1986-2012 IEEE. | Jiao, Yan; Razaq, Mian Muaz; Peng, Limei; Ho, Pin-Han | University of Electronic Science and Technology of China, Shenzhen Institute for Advanced Study, Guangdong, China; Kyungpook National University, School of Computer Science and Engineering, Daegu, 41566, South Korea; University of Electronic Science and Technology of China, Shenzhen Institute for Advanced Study, Guangdong, China, Kyungpook National University, School of Computer Science and Engineering, Daegu, 41566, South Korea; University of Electronic Science and Technology of China, Shenzhen Institute for Advanced Study, Guangdong, China | 59488542400; 57221661906; 7201574271; 7402211578 | auroraplm@gmail.com; pinhanho71@gmail.com; | IEEE Network | IEEE NETWORK | 0890-8044 | 1558-156X | SCIE | COMPUTER SCIENCE, HARDWARE & ARCHITECTURE;ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS;COMPUTER SCIENCE, INFORMATION SYSTEMS | 2024 | 6.3 | 10.3 | 0 | 2025-05-07 | 0 | Internet of Medical Things; IoMT; Large Multimodal Models; LMMs | English | Article in press | 2025 | 10.1109/mnet.2025.3545692 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | Article | High-Energy-Density Li-Ion Batteries Employing Gradient Porosity LiFePO4 Electrode for Enhancing Li-Ion Kinetics and Electron Transfer | Lithium iron phosphate (LFP) cathodes are promising materials for energy storage device applications due to their thermal stability, chemical robustness, cost-effectiveness, and long lifespan. However, their low electronic and ionic conductivity, as well as challenges in achieving high packing density in thick electrodes, limit their practical implementation. In this study, a gradient porosity LFP electrode with a high areal capacity of 6.3 mAh cm−2 and an electrode density of 2.5 g cc−1 is proposed. In electrodes with gradient porosity, binder migration is mitigated, ensuring a uniform binder distribution that enhances Li-ion kinetics and adhesion strength between the electrode and aluminum current collector. Furthermore, by employing a particle with short charge carrier pathways in the bottom layer and a particle with a high tap density in the top layer, facile Li-ion and electron transfer and easier electrode processing can be achieved. The resulting gradient porosity electrode with a high areal capacity of 6.3 mAh cm−2 exhibits excellent cycle stability over 100 cycles in full-cell operation. These findings provide valuable insight into scalable strategies for high-energy-density, cost-effective LFP-based Li-ion batteries. © 2025 The Author(s). Small Structures published by Wiley-VCH GmbH. | Han, Seungmin; Lee, Hyungjun; Yang, Subi; Kim, Jaeik; Jeong, Jinwoo; Lee, Yeseung; Chun, Jinyoung; Roh, Kwang Chul; Kim, Patrick Joohyun; Lee, Dongsoo; Sun, Seho; Jeong, Woojin; Choi, Bogem; Paik, Ungyu; Song, Taeseup; Choi, Junghyun | Department of Energy Engineering, Hanyang University, 222 Wangsimni-ro, Seoul, 04763, South Korea; Department of Energy Engineering, Hanyang University, 222 Wangsimni-ro, Seoul, 04763, South Korea; Emerging Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, Jinju, 52851, South Korea, Department of Applied Chemistry, Kyungpook National University, Daegu, 41566, South Korea; Department of Energy Engineering, Hanyang University, 222 Wangsimni-ro, Seoul, 04763, South Korea; Department of Battery Engineering, Hanyang University, 222 Wangsimni-ro, Seoul, 04763, South Korea; Department of Battery Engineering, Hanyang University, 222 Wangsimni-ro, Seoul, 04763, South Korea; Emerging Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, Jinju, 52851, South Korea; Emerging Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, Jinju, 52851, South Korea; Department of Applied Chemistry, Kyungpook National University, Daegu, 41566, South Korea; School of Chemical, Biological and Battery Engineering, Gachon University, Seongnam-si, Gyeonggi-do, 13120, South Korea; School of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, South Korea; Department of Energy Engineering, Hanyang University, 222 Wangsimni-ro, Seoul, 04763, South Korea; Department of Battery Engineering, Hanyang University, 222 Wangsimni-ro, Seoul, 04763, South Korea; Department of Energy Engineering, Hanyang University, 222 Wangsimni-ro, Seoul, 04763, South Korea; Department of Energy Engineering, Hanyang University, 222 Wangsimni-ro, Seoul, 04763, South Korea, Department of Battery Engineering, Hanyang University, 222 Wangsimni-ro, Seoul, 04763, South Korea; School of Chemical, Biological and Battery Engineering, Gachon University, Seongnam-si, Gyeonggi-do, 13120, South Korea | 58619237900; 57209603170; 58817498700; 57222816593; 55441660500; 59750977600; 16177141700; 35175060800; 57195611779; 57201799820; 56799447300; 59750977700; 59751134200; 7006797606; 25825726200; 59883103900 | upaik@hanyang.ac.kr; tssong@hanyang.ac.kr; junghchoi@gachon.ac.kr; | Small Structures | SMALL STRUCT | N/A | 2688-4062 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 11.3 | 10.3 | 0 | 2025-05-07 | 0 | gradient porosity; Li-ion batteries; lithium iron phosphate; microstructure engineering; thick film electrode | English | Article in press | 2025 | 10.1002/sstr.202500093 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Pathological Characterization of African Swine Fever Viruses With Genetic Deletions Detected in South Korea | African swine fever virus (ASFV) genotype II has been circulating in South Korea, causing substantial economic losses to the Korean pig industry since 2019. Genetic epidemiological investigations using whole-genome sequencing have been conducted to track the genetic evolution of ASFV. Two ASFV strains were detected in domestic pig farms in South Korea, one with a large deletion in the MGF 360-6L gene and the other in the MGF 360-21R gene. Phylogenetic analysis indicated that all Korean isolates belonged to the Asian subgroup of ASFV genotype II and were further divided into distinct subclusters of Korean African swine fever (ASF) group I. To identify the pathological changes caused by the deletion of MGF 360-6L and MGF 360-21R genes, we evaluated their pathogenicity in experimentally infected domestic pigs. No significant changes in pathogenicity were observed compared to other viruses evaluated in our previous studies. All inoculated pigs died 7-10 days post-inoculation (dpi), showing acute forms of illness with common pathological lesions. These results highlight that large genetic deletions can occur naturally in ASFV, but the deletions in MGF 360-6L and MGF 360-21R genes did not alter pathogenicity in domestic pigs. Further research is needed to understand the roles of these genes, especially in viral replication and pathogenicity in wild boars and ticks. | Hong, Seong-Keun; Cho, Ki-Hyun; Kwon, Jung-Hoon; Kim, Da-Won; Kim, Jongho; Kim, Da-Young; Kang, Hae-Eun; Lee, Jong-Soo; Kim, Yeon-Hee | Anim & Plant Quarantine Agcy, Foreign Anim Dis Div, Gimcheon 39660, South Korea; Chungnam Natl Univ, Coll Vet Med, Daejeon 34134, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Anim & Plant Quarantine Agcy, Anim Dis Diagnost Div, Gimcheon 39660, South Korea | Cho, Ki-Hyun/LFR-7256-2024 | 57216438886; 57195330480; 55559800200; 57299949900; 57202162365; 57195573426; 7404071354; 56042332000; 57203809456 | jongsool@cnu.ac.kr; vetyh@korea.kr; | TRANSBOUNDARY AND EMERGING DISEASES | TRANSBOUND EMERG DIS | 1865-1674 | 1865-1682 | 2025 | 1 | SCIE | INFECTIOUS DISEASES;VETERINARY SCIENCES | 2024 | 3 | 10.3 | N/A | 0 | 0 | African swine fever; animal experiment; genetic characterization; next-generation sequencing; pig farms; South Korea; virulence | DOMESTIC PIGS; VIRULENCE; STRAINS; P72; REPLICATION; GENOTYPES | African swine fever; animal experiment; genetic characterization; next-generation sequencing; pig farms; South Korea; virulence | African Swine Fever; African Swine Fever Virus; Animals; Gene Deletion; Phylogeny; Republic of Korea; Sequence Deletion; Sus scrofa; Swine; Virulence; African swine fever; African swine fever virus; agricultural land; animal cell; animal experiment; animal model; animal tissue; Article; controlled study; domestic pig; European wild boar; gene deletion; genotype; high throughput sequencing; inoculation; nonhuman; pathogenicity; pathology; pig; South Korea; virus replication; whole genome sequencing; African swine fever; animal; epidemiology; genetics; pathology; phylogeny; South Korea; virology; virulence | English | 2025 | 2025 | 10.1155/tbed/9917280 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | An evaluation approach to PM2.5 policy effectiveness over South Korea based on a newly proposed scalable spatial decomposition method | Air quality management policies often exhibit spatial inconsistencies in effectiveness due to the diverse spatial scales of air pollution variability, which result from source characteristics as well as geographical and meteorological factors. To address this, the present study proposes a scalable spatial decomposition method to separate spatiotemporal air pollution data into background (nationwide), intercity-scale (tens of kilometers), and neighborhood-scale (several kilometers) components. This decomposition was achieved by introducing spatially varying effective ranges for intercity-scale variability at each station, based on the correlation coefficient distance of the background-removed component. Applying this approach to hourly fine particulate matter (PM2.5) concentrations from 535 monitoring stations across South Korea for 2021-2022, we evaluated the effectiveness of PM2.5 management policies. During the polluted cold season (December to March), the intercity-scale component contributed an average of approximately 18% of the total PM2.5 concentration in the Seoul Metropolitan Area (SMA) and Central Area (CA), which are densely populated and industrialized regions. In contrast, this component helped reduce PM2.5 levels in southeastern coastal areas, where high winds facilitate dispersion. The neighborhood-scale component contributed positively to PM2.5 levels near industrial complexes and ports but negatively in residential and commercial areas. The results demonstrate the effectiveness of central government-led intercity-scale regulations on total emissions allowances in the SMA and CA and highlight the need for additional local management targeting individual point sources near industrial complexes and ports. This study provides intuitive spatial decomposition tools for understanding PM2.5 pollution across spatial scales and offers policymakers a foundation for developing multi-scale mitigation strategies. | Seo, Jihoon; Lee, Ahreum; Park, Doo-Sun R.; Youn, Daeok; Kim, Kyung Hwan; Park, Chang-Eui; Kim, Jin Young | Korea Inst Sci & Technol, Climate & Environm Res Inst, Seoul, South Korea; Seoul Natl Univ, Dept Environm Planning, Seoul, South Korea; Kyungpook Natl Univ, Dept Earth Sci Educ, Daegu, South Korea; Kyungpook Natl Univ, Dept Atmospher Sci, Weather Extremes Educ & Res Team, Daegu, South Korea; Kyungpook Natl Univ, Ctr Atmospher Remote Sensing, Daegu, South Korea; Chungbuk Natl Univ, Dept Earth Sci Educ, Cheongju, South Korea | Youn, Daeok/D-1905-2009; Kim, Kyung/E-4225-2018; park, doo-soon/AAM-7730-2020; Seo, Jihoon/A-9499-2013 | 36515557700; 57207487524; 37117659000; 56234518300; 57202763070; 45661599100; 56714895000 | jykim@kist.re.kr; | ENVIRONMENTAL RESEARCH LETTERS | ENVIRON RES LETT | 1748-9326 | 20 | 1 | SCIE | ENVIRONMENTAL SCIENCES;METEOROLOGY & ATMOSPHERIC SCIENCES | 2024 | 5.6 | 10.4 | 0 | 2025-05-07 | 0 | 0 | PM2.5; spatial decomposition; intercity-scale; neighborhood-scale; policy effectiveness | AIR-QUALITY; REGIONAL CONTRIBUTIONS; SOURCE APPORTIONMENT; POLLUTION; EMISSIONS; SEOUL; CHINA; VARIABILITY; IMPROVEMENT; TRENDS | intercity-scale; neighborhood-scale; PM<sub>2.5</sub>; policy effectiveness; spatial decomposition | Seoul [South Korea]; South Korea; Air pollution control; Bioremediation; Information management; Total quality management; Decomposition methods; Intercity-scale; Management policy; Neighborhood-scale; Neighbourhood; PM 2.5; Policy effectiveness; South Korea; Spatial decompositions; Spatial scale; air quality; atmospheric pollution; decomposition analysis; mitigation; particulate matter; policy implementation; pollution monitoring; scale effect; seasonal variation; spatial distribution; Air quality | English | 2025 | 2025-01-01 | 10.1088/1748-9326/ada2b2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Boosted energy harvesting performance of magneto-mechano-electric generator via photon flash annealing for self-powered IoT sensors | In this paper, we demonstrate a boosted output magneto-mechano-electric (MME) generator consisting of piezoelectric Pb(Mg1/3Nb2/3)O-3-Pb(Zr,Ti)O-3 (PMN-PZT) single crystal and laminated FeBSi alloy (Metglas) prepared by employing photon flash annealing (PFA) treatment. The high-temperature PFA treatment with millisecond-level short pulse irradiation on the Metglas sheet induces surface nanocrystallization, enhances magnetostrictive and mechanical responses. The PFA-treated Metglas-based MME generator exhibits a strong magnetoelectric coupling coefficient of 215 V/cm center dot Oe, an open-circuit root mean square (RMS) voltage of 26 V, and RMS output power of 3 mW at an AC magnetic field of 8 Oe. These values are noticeably larger (similar to 100 % enhancement for output power) than those of pristine Metglas-based MME generators due to the enhanced piezomagnetic coefficient and mechanical quality factor of PFA Metglas. Finally, the output electric energy of the PFA-treated MME generator is utilized to drive an Internet of Things (IoT) device by integrating the MME generator with a power management circuit, a storage capacitor, and an IoT temperature sensor. | Song, Hyunseok; Pattipaka, Srinivas; Hwang, Yun Sik; Peddigari, Mahesh; Min, Yuho; Chung, Kyeongwoon; Park, Jung Hwan; Jeong, Chang Kyu; Lee, Han Eol; Jang, Jongmoon; Park, Kwi-Il; Kim, Sung-Dae; Jeong, Jaewon; Yoon, Woon-Ha; Ryu, Jungho; Hwang, Geon-Tae | Yeungnam Univ, Sch Mat Sci & Engn, Gyongsan Si 38541, Gyeongsangbuk D, South Korea; Pukyong Natl Univ, Dept Mat Sci & Engn, 45 Yongso Ro, Busan 48513, South Korea; Kumoh Natl Inst Technol, Dept Mech Engn, Dept Aeronaut Mech & Elect Convergence Engn, 61 Daehak Ro, Gumi 39177, Gyeongbuk, South Korea; Indian Inst Technol Hyderabad, Dept Phys, Kandi 502284, Telangana, India; Kyungpook Natl Univ, Sch Mat Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Biofibers & Biomat Sci, Daegu 41566, South Korea; Jeonbuk Natl Univ, Div Adv Mat Engn, Jeonju, Jeonbuk, South Korea; Yeungnam Univ, Dept Elect Engn, Gyongsan 38541, South Korea; Korea Inst Mat Sci KIMS, 797 Changwondaero, Chang Won 51508, Gyeongnam, South Korea | Jeong, Chang Kyu/ADT-8127-2022; Pattipaka, Srinivas/P-2993-2019 | 57216365707; 57189258366; 58408973000; 56316365700; 36782804100; 56416916000; 55716954000; 59916311600; 56415504500; 55851287300; 35280874200; 59916582500; 59820940500; 15833577200; 57201603501; 36704574900 | jhryu@ynu.ac.kr; gthwang@pknu.ac.kr; | MATERIALS TODAY PHYSICS | MATER TODAY PHYS | 2542-5293 | 55 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2024 | 9.7 | 10.4 | 0 | 2025-06-11 | 0 | 0 | Magnetoelectric; Magneto-mechano-electric conversion; Energy harvesting; Photon flash annealing; Self-powered IoT sensor | HEAT-TREATMENT; INTERNET; THINGS | Energy harvesting; Magneto-mechano-electric conversion; Magnetoelectric; Photon flash annealing; Self-powered IoT sensor | Crystal whiskers; Lead alloys; Magnetostrictive devices; Annealing treatments; Electric conversion; Energy; Flash annealing; Magneto-mechano-electric conversion; Magnetoelectrics; Photon flash annealing; Root Mean Square; Self-powered; Self-powered internet of thing sensor; AC generator motors | English | 2025 | 2025-06 | 10.1016/j.mtphys.2025.101758 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Impacts of unilateral US carbon policies on agricultural sector greenhouse gas emissions and commodity markets | This article analyzes the consequences of the United States implementing unilateral policies to reduce greenhouse gas (GHG) emissions from agriculture. The policy representation is based loosely on current and past policy initiatives that have subsidized GHG reductions and considered special treatment for sectors heavily involved in trade. To do so, our first step is to generate new estimates of key parameters, elasticities of demand and supply, that are critical to understanding interactions among agricultural commodities, such as between livestock and crop products, in this area of research and more broadly. We apply these parameters in a widely used economic model that estimates the effects of a unilateral U.S. agricultural GHG policy on both domestic and foreign markets as well as global GHG emissions. Livestock effects dominate, driving most U.S. livestock product consumer prices higher and causing mixed crop and crop product price effects. A unilateral policy increases food costs in the implementing country and, if applied to all supplies, domestic and imported, tends to raise prices elsewhere as well. Alternative implementation strategies, such as not imposing the costs on exports or not imposing the costs on imports, can lead to lower food prices and greater consumption in other countries, as well as have important implications for the overall GHG reductions achieved by the unilateral effort. | Adenauer, Marcel; Adjemian, Michael K.; Arita, Shawn; Brorsen, Wade; Cooper, Joseph; Goh, Gyuhyeong; Karali, Berna; Mallory, Mindy Lyn; Thompson, Wyatt; Yu, Jisang | Org Econ Cooperat & Dev, Paris, France; Univ Georgia, Athens, GA USA; USDA, Off Chief Economist, Washington, DC USA; Oklahoma State Univ, Stillwater, OK USA; Kyungpook Natl Univ, Daegu, South Korea; Purdue Univ, W Lafayette, IN USA; Univ Missouri, Columbia, MO 65211 USA; Kansas State Univ, Manhattan, KS USA | Yu, Jisang/MZQ-5402-2025; Adjemian, Michael/X-3833-2019 | 28067590100; 25031396500; 55661853200; 59553005100; 57216359833; 55964615700; 28067896700; 35409816600; 16305550100; 57200406920 | thompsonw@missouri.edu; | ENVIRONMENTAL RESEARCH LETTERS | ENVIRON RES LETT | 1748-9326 | 20 | 2 | SCIE | ENVIRONMENTAL SCIENCES;METEOROLOGY & ATMOSPHERIC SCIENCES | 2024 | 5.6 | 10.4 | 0 | 2025-05-07 | 1 | 1 | agricultural emissions; border adjustments; climate policy; elasticities; greenhouse gas; agricultural trade | agricultural emissions; agricultural trade; border adjustments; climate policy; elasticities; greenhouse gas | United States; Agricultural economics; Low emission; Agricultural emissions; Agricultural sector; Agricultural trade; Border adjustment; Carbon policy; Climate policy; Commodities market; Greenhouse gas emissions; Greenhouse gas reductions; Greenhouses gas; agricultural emission; commodity; economic conditions; emissions trading; environmental policy; greenhouse gas; price determination; spatiotemporal analysis; Greenhouse gas emissions | English | 2025 | 2025-02-01 | 10.1088/1748-9326/ada2ac | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Isoquercitrin Suppresses Esophageal Squamous Cell Carcinoma (ESCC) by Inducing Excessive Autophagy and Promoting Apoptosis via the AKT/mTOR Signaling Pathway | Esophageal squamous cell carcinoma (ESCC), one of the most frequent malignant tumors of the digestive system, is marked by a poor prognosis and high mortality rate. There is a critical need for effective therapeutic strategies with minimal side effects. Isoquercitrin (IQ) is a natural compound with potent antioxidant properties in cancer and cardiovascular diseases. However, its specific effects and mechanisms in ESCC remain largely unexplored. This study aims to investigate the effects of IQ in ESCC cells and elucidate the mechanisms underlying its therapeutic effects. Specifically, its impact on cell proliferation, colony formation, migration, and invasion was assessed using cell viability assay, morphology, transwell, and colony formation assays. The effects on apoptosis were evaluated by flow cytometry, while immunofluorescence (IF) staining and Western blotting were performed to confirm the underlying mechanisms. The in vivo anti-cancer effects of IQ were then evaluated using a xenograft tumor model. Our results demonstrate that IQ inhibits ESCC cell growth and colony formation while promoting its apoptosis by enhancing caspase activation and downregulating Bcl-2 expression. Furthermore, IQ suppresses cell migration by modulating the epithelial-mesenchymal transition-related proteins. Additionally, IQ induces excessive autophagy by promoting reactive oxygen species accumulation and inhibiting the AKT/mTOR signaling pathway. Importantly, IQ effectively reduces tumor growth in vivo, highlighting its potential as a therapeutic agent for ESCC. | Liu, Zhibin; Huang, Ke; Huang, Hai; Kim, Eungyung; Kim, Hyeonjin; Kim, Chae Yeon; Kim, Dong Joon; Lee, Sang In; Kim, Sangsik; Kim, Do Yoon; Liu, Kangdong; Ryoo, Zae Young; Lee, Mee-Hyun; Ma, Lei; Kim, Myoung Ok | Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Dept Anim Sci & Biotechnol, Sangju Si 37224, Gyeongsangbuk D, South Korea; Henan Univ Chinese Med, Tradit Chinese Med Zhong Jing Sch, Henan Int Joint Lab TCM Syndrome & Prescript Signa, Zhengzhou 450046, Peoples R China; Univ Texas Hlth Sci Ctr San Antonio, Sch Dent, Dept Oral & Maxillofacial Surg, San Antonio, TX 78229 USA; Dankook Univ, Coll Med, Dept Microbiol, Cheonan 31116, Chungcheongnam, South Korea; Kyungpook Natl Univ, Dept Energy Chem Engn, Sangju Si 37224, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Convergence Res Ctr Mech & Chem Engn, 2559 Gyeongsang Daero, Sangju Si 37224, Gyeongsangbuk D, South Korea; Gyeongsangbukdo Livestock Res Inst, Yeongju 36052, Gyeongsangbuk D, South Korea; China US Henan Hormel Canc Inst, Zhengzhou 450008, Peoples R China; Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat Biores Grp BK21, Daegu 41566, Gyeongsangbuk D, South Korea; Dongshin Univ, Coll Korean Med, Korean Med Res Ctr Biwi Control Based Gut Brain Sy, Naju Si 58245, Jeollanam Do, South Korea | ; Kim, Dong Joon/KDN-8414-2024; RYOO, ZAEYOUNG/AAQ-1573-2020; Liu, Zhibin/AAL-6838-2021 | 58640210100; 58639636600; 57215021952; 57217871658; 57343180400; 57966906800; 57203012616; 57203597336; 56158171800; 57223194600; 56890019100; 59510682500; 58960253600; 57217867673; 8934745900 | liuzhibin1124@naver.com; hk842767619@gmail.com; huanghai1227@126.com; wjddn5460@naver.com; jenus4@naver.com; yyok1012@naver.com; djkim@hci-cn.org; silee78@knu.ac.kr; sangsik@knu.ac.kr; kdy51311@korea.kr; kdliu@zzu.edu.cn; jaewoong64@knu.ac.kr; mhlee@dsu.ac.kr; leima7597@knu.ac.kr; ok4325@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 14 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2024 | 6.6 | 10.4 | 0 | 0 | esophageal squamous cell carcinoma; AKT/mTOR; anti-cancer; excessive autophagy; apoptosis | OXIDATIVE STRESS; CANCER; DEATH; TRANSDUCTION; EPIDEMIOLOGY; INHIBITION; MECHANISMS | AKT/mTOR; anti-cancer; apoptosis; esophageal squamous cell carcinoma; excessive autophagy | English | 2025 | 2025-06-08 | 10.3390/antiox14060694 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Macroporous Resin Recovery of Antioxidant Polyphenol Compounds from Red Onion (Allium cepa L.) Peel | In this study, polyphenols in the crude extract (CE) from red onion peel were recovered by macroporous resin, and their antioxidant and anti-inflammatory activities were evaluated. Among the four resins screened (SP850, XAD2, XAD7HP, and XAD16N), XAD7HP showed the highest desorption and recovery ratios, and it was used to optimize polyphenol recovery through single-factor experiments. The optimal conditions were established as 1 g resin, pH 4, 25 degrees C, 7 h for adsorption, followed by desorption with 70% ethanol for 1 h at 25 degrees C. These conditions achieved 85.00% adsorption ratio, 87.10% desorption ratio, and 20.9% yield of the macroporous resin-recovered extract (MRE) from the CE. HPLC analysis revealed that rosmarinic acid, quercetin, and myricetin were major compounds in the MRE, with the content of these compounds higher (about 7-fold) compared to the CE, confirming enhanced recovery of polyphenols by macroporous resin. Moreover, FT-IR and H-1-NMR analysis confirmed the successful recovery of these polyphenol compounds in the MRE. Furthermore, the MRE displayed significantly improved antioxidant activities (DPPH, ABTS, and FRAP) and anti-inflammatory activities (inhibition of nitric oxide synthesis and reactive oxygen species production) compared to the CE. In summary, our findings suggest that macroporous resin can effectively recover polyphenol compounds from red onion peel extract and enhance their biological activities. | Aliya, Khanafina; Cho, Ha-Seong; Olawuyi, Ibukunoluwa Fola; Park, Ju-Hwi; Nam, Ju-Ock; Lee, Won-Young | Kyungpook Natl Univ, Sch Food Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea | Olawuyi, Ibukunoluwa/H-1232-2018; Lee, Wonyoung/AAL-2780-2021 | 59517640200; 58188941600; 57204471854; 59073815500; 7201496105; 57195940408 | khanafinaaliya@gmail.com; hasung31694@knu.ac.kr; ifolawuyi@knu.ac.kr; qkrwn9809@gmail.com; namjo@knu.ac.kr; wonyoung@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 14 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2024 | 6.6 | 10.4 | 0 | 2025-05-07 | 1 | 1 | red onion peel; polyphenol compounds; macroporous resin; recovery; antioxidant and anti-inflammatory activities | PHENOLIC CONTENT; ROSMARINIC ACID; PURIFICATION; ADSORPTION; EXTRACTS; FLAVONOIDS; SEPARATION; QUERCETIN; LEAVES; NMR | antioxidant and anti-inflammatory activities; macroporous resin; polyphenol compounds; recovery; red onion peel | English | 2025 | 2025-02 | 10.3390/antiox14020145 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Metabolic Profiling of Fermented Products of the Ethanolic Extract of Acanthopanax sessiliflorus Fruit and Evaluation of Its Immune Enhancement Effect in RAW 264.7 Macrophages and BV2 Microglia | In this study, we sought to evaluate the potential availability of 30% ethanol extract of Acanthopanax sessiliflorus fruit (ASE) as a prebiotic and compare the immune enhancement effect of ASE and its fermented products, which were fermented with three probiotic bacteria, namely, Lactobacillus plantarum (ASE-LPF), Streptococcus thermophilus (ASE-STF), and Lactobacillus helveticus (ASE-LHF). RAW264.7 and BV2 cells were treated with various concentrations of ASE and its fermented products. The level of nitric oxide was evaluated using a Griess reagent, and the levels of inflammatory cytokines were determined through an enzyme-linked immunosorbent assay. Western blot analysis was employed to determine the expression of various proteins related to immune responses. Our results show that fermentation with ASE significantly improved the probiotic growth of S. thermophilus and L. helveticus. Compared with ASE, treatment with only ASE-LHF increased the level of nitric oxide. Compared with ASE, treatment with ASE-LHF augmented the expression of inducible nitric oxide synthase, cyclooxygenase-2, and the production of inflammatory cytokines. It was confirmed that these enhancement effects were due to the activation of the nuclear factor kappa B and extracellular signal-regulated kinase mitogen-activated protein kinase signaling pathways. Additionally, secondary metabolite profiling of ASE and its fermented products was performed using UPLC-QTOF/MS to identify ASE's promising compounds. Through metabolomic analysis, 23 metabolites showing significant differences between ASE and its fermented products were compared. Therefore, this study demonstrates the possibility of ASE-LHF as a potential material for immune-enhancing agents. | Kim, Kwan-Woo; Choi, Bo-Ram; Shin, Woo-Cheol; Jang, Jin-Kyu; Lee, Young-Seob; Yoon, Dahye; Lee, Dae Young | Rural Dev Adm, Natl Inst Hort & Herbal Sci, Dept Herbal Crop Res, Eumsung 27709, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea | 57188988057; 57194340567; 57212601607; 58756632600; 37030914700; 55855383700; 57750904900 | dylee80@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 14 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2024 | 6.6 | 10.4 | 0 | 2025-05-07 | 0 | 0 | Acanthopanax sessiliflorus fruit; fermentation; prebiotics; fermented product; immune enhancement effect; macrophage; microglia | PERFORMANCE LIQUID-CHROMATOGRAPHY; NF-KAPPA-B; NITRIC-OXIDE; ROOT BARK; CONSTITUENTS; CYTOKINES; PREBIOTICS; MICROBIOTA; INNATE; ALPHA | Acanthopanax sessiliflorus fruit; fermentation; fermented product; immune enhancement effect; macrophage; microglia; prebiotics | English | 2025 | 2025-03-27 | 10.3390/antiox14040397 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Protective Effects of Atractylodis Rhizoma Extracts on Lung Injury Induced by Particulate Matter 2.5 in Mice | This study investigated the lung-protective effects of Atractylodis Rhizoma extracts (the root of Atractylodes japonica Koidz. ex Kitam), known as AJ extracts, in mitigating subacute pulmonary injuries caused by particulate matter 2.5 (PM2.5) exposure in Balb/c mice. AJ was given orally at concentrations of 400, 200, and 100 mg/kg, demonstrating a promising impact by mitigating oxidative stress and inflammation associated with phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and p38 mitogen-activated protein kinase alpha (p38 MAPK alpha) pathways and reducing mucus overproduction. These protective effects were achieved through the downregulation of p38 MAPK alpha and PI3K/Akt mRNA expressions, enhanced anti-inflammatory and antioxidant activities, and increased mucolytic expectorant effects arbitrated by elevated lung acetylcholine (ACh) and substance P levels, along with decreased mRNA expressions of MUC5AC and MUC5B. Importantly, these outcomes occurred without significant hepatotoxicity. While all AJ dosages provided dose-dependent pulmonary protection, their effects were less pronounced than those of dexamethasone (DEXA) at 0.75 mg/kg. However, AJ uniquely exhibited mucolytic expectorant activities absent in DEXA-treated mice. The results indicate that A. japonica may serve as a potential candidate for creating alternative treatments for respiratory conditions or as an ingredient in functional foods. | Yun, Eun-Hee; Bashir, Khawaja Muhammad Imran; Lee, Jeongjun; Chung, Hunsuk; Kwon, Young-Sam; Choi, Jae-Suk; Ku, Sae-Kwang | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Surg, Daegu 41566, South Korea; Gyeongsang Natl Univ, Inst Marine Ind, Dept Seafood Sci & Technol, Tongyeong 53064, South Korea; German Engn Res & Dev Ctr Life Sci Technol Med & E, Busan 46742, South Korea; GAPI BIO Co Ltd, Hwaseong 18622, South Korea; Daegu Haany Univ, Coll Korean Med, Dept Anat & Histol, Gyongsan 38610, South Korea | BASHIR, KHAWAJA MUHAMMAD IMRAN/J-9192-2018 | 59654503800; 56488376400; 57214357024; 59403883000; 7403459426; 35104615200; 7006331005 | jsc1008@gnu.ac.kr; gucci200@dhu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 14 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2024 | 6.6 | 10.4 | 0 | 2025-05-07 | 0 | 0 | antioxidant defense system; Atractylodes japonica; dexamethasone; natural respiratory refinement medicinal food ingredient; pulmonary protective effect | HOSPITAL ADMISSIONS; ATRACTYLENOLIDE-III; OXIDATIVE STRESS; EPITHELIAL-CELLS; AIR-POLLUTION; MUC5B MUCINS; PM2.5; INFLAMMATION; EXPRESSION; MECHANISM | antioxidant defense system; Atractylodes japonica; dexamethasone; natural respiratory refinement medicinal food ingredient; pulmonary protective effect | English | 2025 | 2025-02 | 10.3390/antiox14020127 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Restoring Glutathione Homeostasis in Glycation-Related Eye Diseases: Mechanistic Insights and Therapeutic Interventions Beyond VEGF Inhibition | Advanced glycation end-products (AGEs) and oxidative stress are recognized as central contributors to the pathogenesis of age-related or diabetic cataracts, diabetic retinopathy (DR), and age-related macular degeneration (AMD). These glycation-related diseases are characterized by impaired redox balance and decreased glutathione (GSH) levels. This review aims to examine the mechanistic links between AGEs and GSH depletion across ocular tissues by integrating in vitro, ex vivo, in vivo, and clinical studies relevant to this topic. The multiple levels of evidence highlight GSH homeostasis as both a biomarker and therapeutic target in glycation-related ocular disorders. Therapeutic strategies aimed at restoring GSH homeostasis under glycation stress are categorized into four mechanistic domains: (I) promoting GSH supply and synthesis, (II) enhancing GSH recycling, (III) mitigating glycation stress, and (IV) reducing oxidative and nitrosative stress. Most of these strategies have been explored via different approaches, and experimental findings with various interventions have shown promise in restoring GSH balance and mitigating AGE-induced damage. A pathological link between GSH depletion and vascular endothelial growth factor (VEGF) overexpression is observed in DR and wet AMD. GSH-centered interventions act upstream to modulate redox homeostasis while anti-VEGF therapies target downstream angiogenesis. This study supports the rationale for a dual-targeting strategy that combines redox-based interventions with VEGF inhibition in glycation-related ocular diseases. | Boo, Yong Chool | Kyungpook Natl Univ, Sch Med, Dept Mol Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea | 6602899130 | ycboo@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 14 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2024 | 6.6 | 10.4 | 0 | 0 | advanced glycation end-products; glutathione; oxidative stress; cataracts; diabetic retinopathy; age-related macular degeneration; aldose reductase inhibitors; glyoxalase; redox homeostasis | FUNGAL METABOLITE NIGERLOXIN; OXIDATIVE STRESS; END-PRODUCTS; INDUCED CYTOTOXICITY; LENS ABNORMALITIES; MAILLARD REACTIONS; DIABETIC-CATARACT; ALPHA-CRYSTALLIN; AGE; DAMAGE | advanced glycation end-products; age-related macular degeneration; aldose reductase inhibitors; cataracts; diabetic retinopathy; glutathione; glyoxalase; oxidative stress; redox homeostasis | English | 2025 | 2025-06-14 | 10.3390/antiox14060731 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Review | Synthetic and Natural Agents Targeting Advanced Glycation End-Products for Skin Anti-Aging: A Comprehensive Review of Experimental and Clinical Studies | Advanced glycation end-products (AGEs) cause blood vessel damage and induce diabetic complications in various organs, such as the eyes, kidneys, nerves, and skin. As glycation stress causes aesthetic, physical, and functional changes in the skin, glycation-targeting skin anti-aging strategies are attracting attention in cosmetology and dermatology. The primary goal of this review is to understand the significance of glycation-induced skin aging and to examine the therapeutic potential of glycation-targeting strategies. This study covers experimental and clinical studies exploring various interventions to attenuate glycation-induced skin aging. Glycation stress decreases the viability of cells in culture media, the cell-mediated contraction of collagen lattices in reconstructed skin models, and the expression of fibrillin-1 at the dermo-epidermal junction in the skin explants. It also increases cross-links in tail tendon collagen in animals, prolonging its breakdown time. However, these changes are attenuated by several synthetic and natural agents. Animal and clinical studies have shown that dietary or topical administration of agents with antiglycation or antioxidant activity can attenuate changes in AGE levels (measured by skin autofluorescence) and skin aging parameters (e.g., skin color, wrinkles, elasticity, hydration, dermal density) induced by chronological aging, diabetes, high-carbohydrate diets, ultraviolet radiation, or oxidative stress. Therefore, the accumulating experimental and clinical evidence supports that dietary supplements or topical formulations containing one or more synthetic and natural antiglycation agents may help mitigate skin aging induced by AGEs. | Choi, Joon Yong; Ha, Nam Gyoung; Lee, Weon Ju; Boo, Yong Chool | Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Dermatol, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea | 57576409100; 57772600900; 24474659000; 6602899130 | halo134679@knu.ac.kr; mkolp0515@gmail.com; weonju@knu.ac.kr; ycboo@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 14 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2024 | 6.6 | 10.4 | 0 | 2025-05-07 | 1 | 1 | advanced glycation end-products; skin aging; anti-aging; antiglycation; antioxidant; cosmetics; dermatology; plant extract; phytochemical; glycation inhibitor | COLLAGEN CROSS-LINKING; OXIDIZED PROTEIN HYDROLASE; IN-VITRO; OXIDATIVE STRESS; ANTI-GLYCATION; RECONSTRUCTED-SKIN; NONINVASIVE MEASUREMENT; OXIDANT STRESS; TAIL COLLAGEN; FACIAL SKIN | advanced glycation end-products; anti-aging; antiglycation; antioxidant; cosmetics; dermatology; glycation inhibitor; phytochemical; plant extract; skin aging | English | 2025 | 2025-04-20 | 10.3390/antiox14040498 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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