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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Layer-resolved release of epitaxial layers in III-V heterostructure via a buffer-free mechanical separation technique | Layer-release techniques for producing freestanding III-V epitaxial layers have been actively developed for heterointegration of single-crystalline compound semiconductors with Si platforms. However, for the release of target epitaxial layers from III-V heterostructures, it is required to embed a mechanically or chemically weak sacrificial buffer beneath the target layers. This requirement severely limits the scope of processable materials and their epi-structures and makes the growth and layer-release process complicated. Here, we report that epitaxial layers in commonly used III-V heterostructures can be precisely released with an atomic-scale surface flatness via a buffer-free separation technique. This result shows that heteroepitaxial interfaces of a normal lattice-matched III-V heterostructure can be mechanically separated without a sacrificial buffer and the target interface for separation can be selectively determined by adjusting process conditions. This technique of selective release of epitaxial layers in III-V heterostructures will provide high fabrication flexibility in compound semiconductor technology. | Park, Honghwi; Won, Heungsup; Lim, Changhee; Zhang, Yuxuan; Han, Won Seok; Bae, Sung-Bum; Lee, Chang-Ju; Noh, Yeho; Lee, Junyeong; Lee, Jonghyung; Jung, Sunghwan; Choi, Muhan; Lee, Sunghwan; Park, Hongsik | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Appl Mat Korea Ltd, Cheongju 28378, Chungcheongbuk, South Korea; Purdue Univ, Sch Engn Technol, W Lafayette, IN 47907 USA; Elect & Telecommun Res Inst, Daejeon 34129, South Korea; Dankook Univ, Dept Mech Engn, Yongin 16890, Gyenggi Do, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | Park, Jung Hyun/HJA-3755-2022; Lee, Sunghwan/J-5424-2014; Lee, Chang-Ju/W-8546-2019; Park, Honghwi/KIC-1871-2024 | 57206811785; 57218567994; 57211605117; 57406888900; 7401900032; 7202714622; 8943234400; 57219441295; 57210867037; 57227779600; 56300483000; 7402093793; 57192514024; 35366976200 | hpark@ee.knu.ac.kr; | SCIENCE ADVANCES | SCI ADV | 2375-2548 | 8 | 3 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 13.6 | 8.9 | 0.85 | 2025-06-25 | 12 | 13 | SILICON INTEGRATED-CIRCUITS; INGAAS/INP SUPERLATTICES; HETEROGENEOUS INTEGRATION; RECENT PROGRESS; THIN SILICON; GAAS; GROWTH; STRAIN; PHOTOVOLTAICS; INP/INGAAS | Epitaxial growth; Semiconductor device manufacture; Separation; Atomic scale; Compound semiconductors; Crystalline compounds; Heteroepitaxial; Mechanical separation; Processable materials; Release process; Separation techniques; Single-crystalline; Surface flatness; Heterojunctions | English | 2022 | 2022-01 | 10.1126/sciadv.abl6406 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Platycodin D Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis by Blocking the Activation of Mitogen-Activated Protein Kinases and the Production of Interleukin-8 | Platycodin D is a major constituent in the root of Platycodon grandiflorwn and has diverse pharmacologic activities, including anti-inflammatory, anti-allergic, and antitumor activities. Vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) are potent angiogenic factors and contribute to tumor angiogenesis by directly and indirectly promoting angiogenic processes, including the proliferation, adhesion, migration, and tube formation of endothelial cells. Here, we found that platycodin D at noncytotoxic concentrations inhibited VEGF-induced proliferation, adhesion to the extracellular matrix proteins fibronectin and vitronectin, chemotactic motility, and tube formation of human umbilical vein endothelial cells (HUVECs). Platycodin D reduced the phosphorylation of extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) and the secretion of IL-8 in VEGF-stimulated HUVECs. Moreover, platycodin D inhibited tube formation and the phosphorylation of ERK and p38 in IL-8-stimulated HUVECs. The in vim) anti-angiogenic activity of platycodin D was confirmed by in vivo experimental models. Platycodin D inhibited the formation of new blood vessels into mouse Matrigel plugs with VEGF or IL-8. In mice injected with MDA-MB-231 human breast cancer cells, orally administered platycodin D inhibited tumor growth, the number of CD34(+) vessels, and the expression of VEGF and L-8. Taken together, platycodin D directly and indirectly prevents VEGF-induced and IL-8-induced angiogenesis by blocking the activation of mitogen-activated protein kinases (MAPKs). Platycodin D may be beneficial for the prevention or treatment of tumor angiogenesis and angiogenesis-related human diseases. | Son, Ju-Ah; Lee, Sun Kyoung; Park, Junhee; Jung, Min Ju; An, So-Eun; Yang, Hye Ji; Son, Seung Hwa; Kim, Ki Rim; Park, Kwang-Kyun; Chung, Won-Yoon | Yonsei Univ, Dept Oral Biol, Coll Dent, 50 Yonsei Ro, Seoul 03722, South Korea; Yonsei Univ, Oral Canc Res Inst, Coll Dent, Seoul 03722, South Korea; Yonsei Univ, BK21 Four Project, Coll Dent, Seoul 03722, South Korea; Yonsei Univ, Grad Sch, Dept Appl Life Sci, Seoul 03722, South Korea; Kyungpook Natl Univ, Coll Sci & Engn, Dept Dent Hyg, Sangju 37224, South Korea | ; Park, Junhee/ABI-3588-2020 | 35206736900; 37056867800; 57205667247; 57220088767; 57850067700; 57849116100; 24400193300; 35793746200; 57214310459; 7401983103 | wychung@yuhs.ac; | AMERICAN JOURNAL OF CHINESE MEDICINE | AM J CHINESE MED | 0192-415X | 1793-6853 | 50 | 06 | SCIE | INTEGRATIVE & COMPLEMENTARY MEDICINE;MEDICINE, GENERAL & INTERNAL | 2022 | 5.7 | 8.9 | 1.68 | 2025-06-25 | 8 | 9 | Platycodin D; Tumor Angiogenesis; VEGF; MAPKs; Interleukin-8 | CELL-MIGRATION; CANCER; APOPTOSIS; SUPPRESSION; AUTOPHAGY | Interleukin-8; MAPKs; Platycodin D; Tumor Angiogenesis; VEGF | Angiogenesis Inhibitors; Animals; Cell Movement; Extracellular Signal-Regulated MAP Kinases; Human Umbilical Vein Endothelial Cells; Humans; Interleukin-8; Mice; Neovascularization, Pathologic; Saponins; Triterpenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; 2 methoxyestradiol; angiogenesis inhibitor; CD34 antigen; fibronectin; interleukin 8; lactate dehydrogenase; mitogen activated protein kinase; mitogen activated protein kinase 1; platycodin d; scleroprotein; stress activated protein kinase; unclassified drug; vasculotropin; vasculotropin receptor 2; vitronectin; angiogenesis inhibitor; interleukin 8; mitogen activated protein kinase; platycodin D; saponin; triterpene; vasculotropin; vasculotropin A; angiogenesis; animal experiment; antiangiogenic activity; antineoplastic activity; Article; breast cancer; cancer inhibition; capillary endothelial cell; cell adhesion; cell migration; cell motility; cell proliferation; cell viability; chemotaxis; controlled study; cytotoxicity; DNA synthesis; enzyme linked immunosorbent assay; female; gene expression; human; human cell; immunohistochemistry; in vitro study; in vivo study; lactate dehydrogenase blood level; male; MDA-MB-231 cell line; microvasculature; mouse; nonhuman; protein expression; protein phosphorylation; tumor growth; tumor volume; tumor xenograft; umbilical vein endothelial cell; animal; cell motion; metabolism; neovascularization (pathology) | English | 2022 | 2022 | 10.1142/s0192415x22500690 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The prevalence, risk of premature births, mortality and causes of death of cleft lip with or without palate in South Korea: a nationwide population-based cohort study | Background Very few recent nationwide studies have assessed the epidemiology of cleft lip with or without palate (CL/P). The purpose of this study was to identify the prevalence, risk of premature births, mortality and cause of death of CL/P. Methods This nationwide population-based cohort study evaluated all 5 747 830 live births in South Korea, including CL/P infants, from 2006 to 2018. The prevalence with trend analysis, risk of premature births, mortality and cause of death of CL/P with or without associated syndromes (non-syndromic, syndromic CL/P) and subgroups (cleft lip only, cleft palate only, cleft lip with palate) were evaluated. Results Among 5 747 830 live births, 11 284 children were identified as having CL/P during the study period. The annual prevalence was 1.96 per 1000 births. The prevalence ratio, which shows the trend during the period, was 1.021. Both non-syndromic and syndromic CL/P children had higher risk of premature births compared with children without CL/P (odds ratio: non-syndromic 1.43, syndromic 5.29). The mortality rates per 1000 person-years were 0.39 for children without CL/P, 0.98 for non-syndromic CL/P children and 12.20 for syndromic CL/P children. The causes of deaths were not different for children without CL/P in non-syndromic CL/P, but the most common cause of deaths was cardiovascular anomalies in syndromic CL/P. Conclusion The reported prevalence of 1.96 per 1000 births is one of the highest prevalences worldwide. CL/P children had high risks of premature births and risk of mortality. The most common cause of deaths was cardiovascular anomalies. | Ryu, Jeong Yeop; Park, Tae Hyun; Cho, Byung Chae; Choi, Kang Young | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 680 Gukchaebosanro, Daegu 41405, South Korea | ; Ryu, Jeong Yeop/GLQ-9419-2022 | 56366349400; 57223690181; 55662871100; 57203745682 | kychoi@knu.ac.kr; | INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | INT J EPIDEMIOL | 0300-5771 | 1464-3685 | 51 | 3 | SCIE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2022 | 7.7 | 8.9 | 1.83 | 2025-06-25 | 17 | 17 | Cleft lip; cleft palate; prevalence; premature birth; mortality; cause of death | TRENDS | cause of death; Cleft lip; cleft palate; mortality; premature birth; prevalence | Abnormalities, Multiple; Cause of Death; Child; Cleft Lip; Cleft Palate; Cohort Studies; Female; Genetic Diseases, X-Linked; Humans; Ichthyosiform Erythroderma, Congenital; Infant; Limb Deformities, Congenital; Palate; Pregnancy; Premature Birth; Prevalence; South Korea; birth rate; cause of death; cohort analysis; epidemiology; mortality; mortality risk; Article; cardiovascular malformation; cause of death; child; cleft lip; cleft lip palate; cleft lip with or without cleft palate; cleft palate; cohort analysis; controlled study; digestive system disease; endocrine disease; female; hematologic disease; human; live birth; major clinical study; male; metabolic disorder; mortality; mortality rate; neurologic disease; newborn; nonsyndromic cleft lip with or without cleft palate; nutritional disorder; parasitosis; perinatal morbidity; population research; prematurity; preschool child; prevalence; prevalence ratio; respiratory tract disease; risk; school child; solid malignant neoplasm; South Korea; trend study; vascular disease; cause of death; cleft lip; cleft palate; congenital ichthyosiform erythroderma; infant; limb malformation; multiple malformation syndrome; palate; pregnancy; prematurity; prevalence; X chromosome linked disorder | English | 2022 | 2022-06-13 | 10.1093/ije/dyac019 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Cold spray-based rapid and scalable production of printed flexible electronics | Flexible electronics (FE) is attracting great attention from both scientific and industrial communities, and plays a crucial role in smart device applications. Despite great promise, traditional printing approaches (e.g., screen printing, ink-jet printing, etc.) often need a high-temperature post-sintering process to produce FE with desired electrical conductivity and adhesion strength. The post-sintering processes, however, often lead to fast oxidation of the functional coating while limiting the use of low-thermal budget substrates. Exponential advance of FE in a large-scale and energy-efficient manner relies on rationally eliminating the post-sintering processes. To this end, with the aim of uncovering process-structure-properties relationships, we employ the emerging cold spray (CS) technique for rapid and scalable production of FE without a need for high-temperature post-sintering. In this regard, micron-scale Tin (Sn) particles are directly written on a flexible polymer substrate (PET) by cold spraying under ambient conditions. The effect of CS process parameters on the resultant coatings is comprehensively characterized in terms of microstructure, film thickness, electrical conductivity, linewidth, and adhesion strength. The resulting electrodes show excellent electrical conductivity (6.98 x 105 S m-1), adhesion strength, long-term stability, and flexibility without significant conductivity loss after 1000 bending cycles. By leveraging the CS operational settings, a resistive macro-heater (12 x 15 cm2) and an LED circuit (2.5 cm x 18 cm) are fabricated to demonstrate the applicability of the CS in printed FE. Moreover, to address the low-spatial reso-lution of CS writing, a case study on sequential CS and femtosecond laser machining is performed, which further led to ultra-high resolution (i.e., 30 mu m linewidth) custom-designed flexible electrodes. Thus, the present study reveals the immense potential of the CS technique for rapid and scalable production of FE without the need for post-sintering. | Akin, Semih; Lee, Seungjun; Jo, Seunghwan; Ruzgar, Duygu Gazioglu; Subramaniam, Karthick; Tsai, Jung -Ting; Jun, Martin Byung-Guk | Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA; Kyungpook Natl Univ, Sch Mech Engn Technol, Daegu 41566, South Korea; Bursa Tech Univ, Met & Mat Engn, TR-16310 Bursa, Turkey; Indian Inst Technol Indore, Dept Mech Engn, Mechatron & Instrumentat Lab, Indore 453552, Madhya Pradesh, India; Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA; Purdue Univ, Indiana Mfg Competitiveness Ctr IN MaC, W Lafayette, IN 47907 USA | Akin, Semih/JMC-7923-2023; Tsai, Jung-Ting/KIE-8368-2024; GAZIOGLU RUZGAR, Duygu/GZN-1718-2022; Akin, Ph.D., Semih/JMC-7923-2023; Subramaniam, Karthick/F-4784-2016 | 57218227618; 57210570019; 57200629533; 57193026952; 57216165076; 55382903500; 24587060000 | sakin@purdue.edu;lee4153@purdue.edu;jo30@purdue.edu;dgaziogl@purdue.edu;subram94@purdue.edu;tsai92@purdue.edu;mbgjun@purdue.edu; | ADDITIVE MANUFACTURING | ADDIT MANUF | 2214-8604 | 2214-7810 | 60 | SCIE | ENGINEERING, MANUFACTURING;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2022 | 11 | 9.0 | 1.53 | 2025-06-25 | 18 | 19 | Additive manufacturing; Cold spray; Printed electronics; Flexible electronics; Direct writing; Sustainable repairing; Laser machining | PARTICLE-ACCELERATION; STANDOFF DISTANCE; COPPER COATINGS; DEPOSITION; PRESSURE; POWDERS | Additive manufacturing; Cold spray; Direct writing; Flexible electronics; Laser machining; Printed electronics; Sustainable repairing | 3D printers; Additives; Adhesion; Adhesives; Bond strength (materials); Budget control; Deposition rates; Electric conductivity; Electrodes; Energy efficiency; Light emitting diodes; Polyethylene terephthalates; Repair; Screen printing; Sintering; Substrates; Cold spray; Direct-writing; Electrical conductivity; Highest temperature; Laser machining; Post-sintering; Printed electronics; Scalable production; Sintering process; Sustainable repairing; Flexible electronics | English | 2022 | 2022-12 | 10.1016/j.addma.2022.103244 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of triethanolamine and sodium hexametaphosphate on formation, growth and breakdown of passive layer in concrete pore solution | In present study, 0.1 (M) triethanolamine (C6H15NO3: TEA) and 0.01 (M) sodium hexametaphosphate [(NaPO3)6: SHMP] have been dissolved in deionized water to synthesize the TS inhibitor solution. Different amounts such as 0.01, 0.10 and 0.25% of TS inhibitor have been taken to study the corrosion performance of steel rebar in 0.6 (M) NaCl contaminated concrete pore (CPNC) solution. The corrosion mechanism and kinetics of the steel rebars in presence of inhibitor have been studied by open circuit potential (OCP), electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDP) with exposure periods while the morphology and nature of passive film formed on rebar surface have been examined by scanning electron microscopy (SEM), atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS), after 192 h of immersion. The steel rebar immersed in without inhibitor solution (CPNC) has exhibited lowest film resistance (Rf) and charge transfer resistance (Rct) with pits formation in passive film. Alternatively, the steel rebars exposed to inhibitor added CPNC solutions show higher in Rf, Rct values, lowest corrosion current density (icorr), nobler OCP and cluster like morphology of the passive films. It is attributed to the adsorption of TEA molecules on the rebar surface by donating lone pair of electrons from N atom while PO3 4 ions (from SHMP) transform the Fe(OH)2 into FePO4. The corrosion inhibition efficiency of the inhibitor containing samples are increased with exposure periods and the maximum is found to be 97.57% by 0.10% TS after 192 h of exposure. | Mandal, Soumen; Singh, Jitendra Kumar; Mallapur, Srinivas; Lee, Dong-Eun; Park, Taejoon | Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak-ro, Daegu 41566, South Korea; Hanyang Univ, Innovat Durable Bldg & Infrastructure Res Ctr, Ctr Creat Convergence Educ, 1271 Sa3-dong, Ansan 15588, South Korea; REVA Univ, Dept Chem, Kattigenahalli, Bangalore 560024, Karnataka, India; Kyungpook Natl Univ, Sch Architecture Environm Civil & Energy, 1370,Sangyegk Dong, Daegu 702701, South Korea; Hanyang Univ, Dept Robot Engn, 55 Hanyangdaehak-ro, Ansan 15588, Gyeonggi do, South Korea | ; Mallapur, Srinivas/GSI-4519-2022; Mandal, Soumen/AAB-3917-2021; Singh, Jitendra/AAU-6579-2021 | 57214752240; 57197846307; 57190860098; 56605563300; 55717001200 | dolee@knu.ac.kr;taejoon@hanyang.ac.kr; | JOURNAL OF BUILDING ENGINEERING | J BUILD ENG | 2352-7102 | 59 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL | 2022 | 6.4 | 9.0 | 1.39 | 2025-06-25 | 13 | 16 | Steel; Corrosion; Inhibitor; Concrete pore solution; Passive film; Electrochemical impedance spectroscopy | RAY PHOTOELECTRON-SPECTROSCOPY; CARBON-STEEL; SIMULATED CONCRETE; CORROSION INHIBITION; MILD-STEEL; ELECTROCHEMICAL-BEHAVIOR; XPS CHARACTERIZATION; REINFORCING STEEL; CHLORIDE; PHOSPHATE | Concrete pore solution; Corrosion; Electrochemical impedance spectroscopy; Inhibitor; Passive film; Steel | Atomic force microscopy; Charge transfer; Deionized water; Electrochemical corrosion; Ethanolamines; Film growth; Iron compounds; Morphology; Scanning electron microscopy; Sodium chloride; Steel corrosion; Triethanolamine; X ray photoelectron spectroscopy; Concrete pore solutions; Electrochemical-impedance spectroscopies; Exposure period; Inhibitor; Open circuit potential; Passive films; Passive layer; Sodium hexametaphosphate; Steel rebars; Triethanolamines; Electrochemical impedance spectroscopy | English | 2022 | 2022-11-01 | 10.1016/j.jobe.2022.105113 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Utilization of phenol formaldehyde/Fe3O4 nanocomposite as microwave preheating amplifier in laminated veneer lumber (LVL) structure | In this study, Phenol Formaldehyde (PF) resin was modified with Fe3O4 nanoparticles (NPs) as microwave (MW) absorber nanocomposite in the LVL structure to accelerate MW preheating of the billet. The presence and distribution of Fe3O4-NPs in PF substrate was confirmed by Energy Dispersive X-Ray Spectroscopy (EDS) and Scanning Electron Microscopy (SEM). Differential Scanning Calorimetry (DSC) analysis also proved that existence of Fe3O4-NPs shortened the curing time of PF composite. According to Fourier Transform Infrared (FT-IR) analysis, Fe3O4-NPs had no effect on the functional groups of PF nanocomposite. Temperature variations throughout the microwave preheating process were used to monitor the MW absorption performance. Surprisingly, higher temperatures were recorded for samples containing Fe3O4-NPs. MW preheated LVL's with 3% Fe3O4-NPs were hot-pressed at a higher initial temperature, causing the core layer temperature to reach 100 degrees C faster. The shear strength and screw withdrawal resistance findings showed that the presence of Fe3O4-NPs had a greater impact on the core layers of LVLs than on the surface layers. Remarkably, MW preheated LVLs containing 2% of Fe3O4-NPs after 8 min of hot-pressing exhibited comparable mechanical characteristics to control samples after 12 min of hot-pressing. These findings show that the PF/Fe3O4-NPs composite improved MW absorption performance while also enhancing LVL mechanical characteristics. | Pour, Mohammad Farajollah; Khanjanzadeh, Hossein; Dorieh, Ali; Kiamahalleh, Mohammad Valizadeh; Hoseini, Kazem Doost | Univ Tehran, Fac Nat Resource, Dept Wood & Sci Technol, Karaj, Iran; Kyungpook Natl Univ, Dept Wood & Paper Sci, Daegu, South Korea; Arian Saeed Ind Grp, Div Res & Dev, Sari, Iran | Dorieh, Ali/AGH-8859-2022; Farajollah Pour, Mohammad/JNS-4294-2023; Khanjanzadeh, Hossein/B-7794-2018 | 57237576900; 37048874200; 57204469176; 57188836144; 55936888500 | Farajallahpour@ut.ac.ir; | JOURNAL OF BUILDING ENGINEERING | J BUILD ENG | 2352-7102 | 46 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL | 2022 | 6.4 | 9.0 | 0.83 | 2025-06-25 | 11 | 9 | Microwave preheating; Phenol formaldehyde; Fe3O4 nanoparticle; Microwave absorber; Physical and mechanical properties | TEMPERATURE BEHAVIOR; CARBON NANOTUBES; SHEAR-STRENGTH; RESIN; WOOD | Fe<sub>3</sub>O<sub>4</sub> nanoparticle; Microwave absorber; Microwave preheating; Phenol formaldehyde; Physical and mechanical properties | Formaldehyde; Heating; Hot Pressing; Microwaves; Phenols; Scanning Electron Microscopy; Differential scanning calorimetry; Energy dispersive spectroscopy; Formaldehyde; Hot pressing; Magnetite; Microwave heating; Nanocomposites; Nanoparticles; Phenols; Preheating; Scanning electron microscopy; Absorption performance; Core layers; Fe3O4 nanoparticle; Laminated veneer lumber; Microwave absorbers; Microwave absorption; Microwave preheating; Phenol formaldehyde; Phenol-formaldehyde; Physical and mechanical properties; Microwaves | English | 2022 | 2022-04-01 | 10.1016/j.jobe.2021.103809 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Inhibition of cathepsin K sensitizes oxaliplatin-induced apoptotic cell death by Bax upregulation through OTUB1-mediated p53 stabilization in vitro and in vivo | Cathepsin K is highly expressed in various types of cancers. However, the effect of cathepsin K inhibition in cancer cells is not well characterized. Here, cathepsin K inhibitor (odanacatib; ODN) and knockdown of cathepsin K (siRNA) enhanced oxaliplatin-induced apoptosis in multiple cancer cells through Bax upregulation. Bax knockdown significantly inhibited the combined ODN and oxaliplatin treatment-induced apoptotic cell death. Stabilization of p53 by ODN played a critical role in upregulating Bax expression at the transcriptional level. Casein kinase 2 (CK2)-dependent phosphorylation of OTUB1 at Ser16 played a critical role in ODN- and cathepsin K siRNA-mediated p53 stabilization. Interestingly, ODN-induced p53 and Bax upregulation were modulated by the production of mitochondrial reactive oxygen species (ROS). Mitochondrial ROS scavengers prevented OTUB1-mediated p53 stabilization and Bax upregulation by ODN. These in vitro results were confirmed by in mouse xenograft model, combined treatment with ODN and oxaliplatin significantly reduced tumor size and induced Bax upregulation. Furthermore, human renal clear carcinoma (RCC) tissues revealed a strong correlation between phosphorylation of OTUB1(Ser16) and p53/Bax expression. Our results demonstrate that cathepsin K inhibition enhances oxaliplatin-induced apoptosis by increasing OTUB1 phosphorylation via CK2 activation, thereby promoting p53 stabilization, and hence upregulating Bax. | Seo, Seung Un; Woo, Seon Min; Kim, Shin; Park, Jong-Wook; Lee, Hyun-Shik; Bae, Young-Seuk; Kim, Sang Hyun; Im, Seung-Soon; Seo, Ji Hae; Min, Kyoung-Jin; Kwon, Taeg Kyu | Keimyung Univ, Sch Med, Dept Immunol, Daegu 42601, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Keimyung Univ, Sch Med, Dept Physiol, Daegu 42601, South Korea; Keimyung Univ, Sch Med, Dept Biochem, Daegu 42601, South Korea; Daegu Gyeongbuk Med Innovat Fdn DGMIF, New Drug Dev Ctr, Daegu 41061, South Korea; Keimyung Univ, Ctr Forens Pharmaceut Sci, Daegu 42601, South Korea | Kim, Shin/D-1669-2013; Park, Jung Hwan/AAA-1951-2022 | 57195411399; 57199873466; 57210866288; 55717085400; 16316010200; 8230659600; 57210450420; 57211749547; 56601533800; 7201466928; 7202206057 | kwontk@dsmc.or.kr; | ONCOGENE | ONCOGENE | 0950-9232 | 1476-5594 | 41 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY;GENETICS & HEREDITY;ONCOLOGY | 2022 | 8 | 9.1 | 1.31 | 2025-06-25 | 16 | 15 | TUMOR-SUPPRESSOR P53; MEMBRANE PERMEABILIZATION; EXPRESSION; BCL-2 | Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cathepsin K; Cell Death; Cell Line, Tumor; Humans; Mice; Oxaliplatin; Tumor Suppressor Protein p53; Up-Regulation; casein kinase II; cathepsin K; odanacatib; oxaliplatin; protein Bax; protein p53; reactive oxygen metabolite; antineoplastic agent; cathepsin K; oxaliplatin; protein Bax; protein p53; animal experiment; animal tissue; antineoplastic activity; apoptosis; Article; cancer inhibition; controlled study; correlational study; disease association; flow cytometry; gene expression regulation; gene knockdown; genetic transcription; human; human cell; human tissue; in vitro study; in vivo study; mouse; nonhuman; oncogene; OTUB1 gene; protein phosphorylation; protein stability; renal cell carcinoma; Ser16 gene; tumor volume; upregulation; animal; apoptosis; cell death; genetics; metabolism; tumor cell line | English | 2022 | 2022-01-21 | 10.1038/s41388-021-02088-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A dose-response relationship of renin-angiotensin system blockers and beta-blockers in patients with acute heart failure syndrome: a nationwide prospective cohort study | Aims It remains unclear if patients with acute heart failure syndrome (AHFS) need to reach the maximally tolerated doses of renin-angiotensin system blockers (RASBs) or beta-blockers (BBs) to obtain a survival benefit. This study evaluated the dose-response relationship between RASBs or BBs and survival in AHFS patients. Methods and results total, 5331 patients in the Korean Acute Heart Failure registry were analysed based on the doses of RASBs and BBs at discharge. In AHFS patients, RASB use at discharge was associated with a significant reduction in all-cause mortality risk. This effect was dose-dependent for heart failure with reduced ejection fraction (HFrEF) but did not attain statistical significance for heart failure with preserved ejection fraction (HFpEF). BB use at discharge was associated with reduced all-cause mortality in HFrEF patients but not in HFpEF patients. In an additional analysis of 4613 patients with dosage information at the first post discharge follow up visit, a significantly higher mortality risk was associated with the maintenance or withdrawal of RASBs compared with up titrating the dose in HFrEF patients. Conclusion Using RASBs or BBs at discharge was associated with improved survival. A dose-response relationship between RASBs and all-cause mortality was evident in AHFS patients with a reduced ejection fraction but not BBs. It is important to initiate and up titrate RASBs to the maximally tolerated dose in AHFS patients during the transition period, especially for patients with a reduced ejection fraction. | Kim, Kyung An; Kim, Eui-Soon; Youn, Jong-Chan; Lee, Hye Sun; Jeon, Soyoung; Lee, Hae-Young; Cho, Hyun-Jai; Choi, Jin-Oh; Jeon, Eun-Seok; Lee, Sang Eun; Kim, Min-Seok; Kim, Jae-Joong; Hwang, Kyung-Kuk; Cho, Myeong-Chan; Chae, Shung Chull; Kang, Seok-Min; Choi, Dong-Ju; Yoo, Byung-Su; Kim, Kye Hun; Oh, Byung-Hee; Baek, Sang Hong | Catholic Univ Korea, Catholic Res Inst Intractable Cardiovasc Dis, Seoul St Marys Hosp, Div Cardiol,Dept Internal Med,Coll Med, Banpo Daero 222, Seoul 06591, South Korea; Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon 34141, South Korea; Yonsei Univ, Biostat Collaborat Unit, Coll Med, Seoul 06229, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul 03080, South Korea; Sungkyunkwan Univ, Coll Med, Dept Internal Med, Seoul 06351, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul 05505, South Korea; Chungbuk Natl Univ, Dept Internal Med, Coll Med, Cheongju 28644, South Korea; Kyungpook Natl Univ, Coll Med, Dept Internal Med, Daegu 41944, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul 03722, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam 13620, South Korea; Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju 26413, South Korea; Chonnam Natl Univ, Dept Cardiovasc Med, Med Sch, Gwangju 61469, South Korea; Mediplex Sejong Hosp, Dept Internal Med, Incheon 14754, South Korea | Jeong, Gi/AAB-2830-2021; Youn, Jong-Chan/AAS-1405-2020; Lee, Hye/J-2154-2015; LEE, JI/L-6920-2013; Lee, Hye Sun/J-2154-2015; Oh, Byung-Hee/G-9875-2011; Choi, Dong-Ju/J-5686-2012; Choi, Joon/D-6140-2017 | 57872084600; 57220956934; 14070921900; 57208650357; 57223622373; 56151235500; 35285421400; 15848011800; 7004279641; 57207065107; 57212315719; 36065764100; 7402426370; 58092080500; 7101962036; 7405685375; 35274349200; 7102851884; 56150430800; 57216293873; 7201371594 | jong.chan.youn@gmail.com;whitesh@catholic.ac.kr; | EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY | EUR HEART J-CARD PHA | 2055-6837 | 2055-6845 | 8 | 6 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS;PHARMACOLOGY & PHARMACY | 2022 | 7.1 | 9.2 | 0.81 | 2025-06-25 | 4 | 6 | Acute heart failure syndrome; Renin-angiotensin system blocker; Beta-blocker; Dose-response relationship; Ejection fraction; Transition period | EJECTION FRACTION; CLINICAL CHARACTERISTICS; TEMPORAL TRENDS; MANAGEMENT; OUTCOMES; THERAPY; CARVEDILOL; GUIDELINES; WITHDRAWAL; MORTALITY | Acute heart failure syndrome; Beta-blocker; Dose–response relationship; Ejection fraction; Renin–angiotensin system blocker; Transition period | angiotensin receptor antagonist; beta adrenergic receptor blocking agent; candesartan; carvedilol; ramipril; renin angiotensin system blocker; renin inhibitor; unclassified drug; acute heart failure; aged; all cause mortality; Article; cohort analysis; controlled study; demographics; disease registry; dose response; drug dose reduction; drug dose titration; drug efficacy; drug information; drug megadose; drug tolerability; female; follow up; hazard ratio; heart ejection fraction; heart failure with reduced ejection fraction; heart left ventricle ejection fraction; high risk patient; hospital discharge; hospital mortality; human; Kaplan Meier method; maintenance therapy; major clinical study; male; mortality risk; multicenter study; observational study; phase transition; proportional hazards model; prospective study; renin angiotensin aldosterone system; risk reduction; statistical significance; survival rate; treatment response; treatment withdrawal; university hospital; very elderly | English | 2022 | 2022-09-03 | 10.1093/ehjcvp/pvac002 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | ??????????????Metal-Coordinated Phthalocyanines as Platform Molecules for Understanding Isolated Metal Sites in the Electrochemical Reduction of CO2 | Single-atom catalysts (SACs) of non-precious transition metals (TMs) often show unique electrochemical performance, including the electrochemical carbon dioxide reduction reaction (CO2RR). However, the inhomogeneity in their structures makes it difficult to directly compare SACs of different TM for their CO2RR activity, selectivity, and reaction mechanisms. In this study, the comparison of isolated TMs (Fe, Co, Ni, Cu, and Zn) is systematically investigated using a series of crystalline molecular catalysts, namely TM-coordinated phthalocyanines (TMPcs), to directly compare the intrinsic role of the TMs with identical local coordination environments on the CO2RR performance. The combined experimental measurements, in situ characterization, and density functional theory calculations of TM-Pc catalysts reveal a TM dependent CO2RR activity and selectivity, with the free energy difference of delta G(*HOCO) - delta G(*CO) being identified as a descriptor for predicting the CO2RR performance. | Chang, Qiaowan; Liu, Yumeng; Lee, Ju-Hyeon; Ologunagba, Damilola; Hwang, Sooyeon; Xie, Zhenhua; Kattel, Shyam; Lee, Ji Hoon; Chen, Jingguang G. | Columbia Univ, Dept Chem Engn, New York, NY 10027 USA; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Florida A&M Univ, Dept Phys, Tallahassee, FL 32307 USA; Brookhaven Natl Lab, Ctr Funct Nanomat, Upton, NY 11973 USA; Brookhaven Natl Lab, Chem Div, Upton, NY 11973 USA | Lee, Ji/AAU-7285-2021; Chen, Jingguang/ABX-2827-2022; Lee, Ji Hoon/T-4913-2017; liu, yumeng/KIJ-2697-2024; Lee, Ju/M-8764-2019; Kattel, Shyam/AAK-6985-2020; Xie, Zhenhua/HKV-7118-2023; Chang, Qiaowan/EHZ-6021-2022; Hwang, Sooyeon/H-8593-2012 | 56524911100; 57213602400; 57486987100; 57216687867; 36859249800; 56597268800; 36497069200; 55689885200; 57201541202 | shyam.kattel@famu.edu;jihoonlee@knu.ac.kr;jgchen@columbia.edu; | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | J AM CHEM SOC | 0002-7863 | 1520-5126 | 144 | 35 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2022 | 15 | 9.3 | 6.7 | 2025-06-25 | 120 | 117 | OXYGEN REDUCTION; EFFICIENT ELECTROREDUCTION; ELECTROCATALYTIC REDUCTION; CRYSTAL-STRUCTURE; SINGLE ATOMS; CATALYSTS; GRAPHENE; EXCHANGE; IRON; GAS | Carbon dioxide; Catalyst selectivity; Density functional theory; Electrolytic reduction; Free energy; Microcomputers; Pollution control; carbon dioxide; cobalt; copper; iron; metal; nickel; phthalocyanine; zinc; Carbon dioxide reduction; Electrochemical performance; Electrochemical reductions; Electrochemicals; Metal sites; Platform molecules; Reduction reaction; Single-atoms; ]+ catalyst; adsorption; Article; catalysis; catalyst; chemical composition; chemical reaction; chemical structure; chronoamperometry; crystallization; density functional theory; electrochemical analysis; metallation; prediction; reduction (chemistry); scanning electron microscopy; structure analysis; X ray diffraction; Transition metals | English | 2022 | 2022-09-07 | 10.1021/jacs.2c06953 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Determination of anthropogenic organics in dichlomethane extracts of aerosol particulate matter collected from four different locations in China and Republic of Korea by GC-MS and FTICR-MS | In this study, the hypothesis that particulate matter in east of Korea peninsula would be significantly influenced by particulate matter originated from east of China was evaluated. To test the hypothesis, water-insoluble com-pounds in particulate matter samples collected from three different locations in Korea and one in China were characterized by atmospheric pressure photoionization (APPI) coupled with Fourier transform ion cyclotron res-onance mass spectrometry (FTICR-MS) and gas chromatography mass spectrometry (GC-MS). Each sample was collected twice, in winter and in spring. The GC-MS data revealed the presence of high levels of polycyclic aro-matic hydrocarbons (PAHs), such as benzo[a]anthracene in the samples from Tianjin, China. The sample collected in the winter from Baengnyeong Island, which is the location in Korea that is geographically closest to the east coast of China was also rich in aromatic compounds. Meanwhile, the APPI FTICR-MS data showed that polycondensed PAHs and two-to four-ring PAHs with long alkyl chains were abundant in the winter samples from Tianjin and Baengnyeong Island which stems most likely from coal combustion in the eastern China. In con -trast, nonaromatic compounds with a biogenic origin were mostly observed in samples collected from islands lo-cated in eastern (Ulleung Island) and southern (Jeju Island) Korea. A principal component analysis by FTICR-MS and GC-MS also showed that the samples from Tianjin and those collected from Baengnyeong Island in the winter are strongly associated with coal combustion, whereas the other samples are mainly influenced by vehicle emissions. Therefore, it is concluded that the atmosphere from east of China has significant influence over atmosphere in west of Korea peninsula. (C) 2021 Elsevier B.V. All rights reserved. | Kim, Donghwi; Kim, Sungjune; Yim, Un Hyuk; Ha, Sung Yong; An, Joon Geon; Loh, Andrew; Kim, Sunghwan | Korea Inst Ocean Sci & Technol, Oil & POPs Res Grp, Geoje 53201, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Mass Spectrometry Convergence Res Ctr, Daegu 41566, South Korea; Green Nano Mat Res Ctr, Daegu 41566, South Korea | ha, sung yong/AAZ-6200-2021; Yim, Un Hyuk/HLQ-2591-2023; Kim, Sunghwan/HKN-9812-2023 | 58839420600; 57221297786; 6602461626; 24329049500; 35174223700; 56471439700; 57203772967 | sunghwank@knu.ac.kr; | SCIENCE OF THE TOTAL ENVIRONMENT | SCI TOTAL ENVIRON | 0048-9697 | 1879-1026 | 805 | SCIE | ENVIRONMENTAL SCIENCES | 2022 | 9.8 | 9.3 | 0.39 | 2025-06-25 | 7 | 7 | Particulate matters; FT-ICR MS; GC-MS; PAH/NONPAH ratios; Principal component analysis | POLYCYCLIC AROMATIC-HYDROCARBONS; HUMIC-LIKE SUBSTANCES; BLACK CARBON EMISSIONS; LONG-RANGE TRANSPORT; RIVER DELTA REGION; FT-ICR MS; MOLECULAR CHARACTERIZATION; SOURCE APPORTIONMENT; AIRBORNE PARTICLES; AMBIENT AEROSOLS | FT-ICR MS; GC–MS; PAH/NONPAH ratios; Particulate matters; Principal component analysis | Aerosols; Air Pollutants; China; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Mass Spectrometry; Particulate Matter; Polycyclic Aromatic Hydrocarbons; Republic of Korea; Seasons; China; Korea; Tianjin; Atmospheric pressure; Coal; Coal combustion; Gas chromatography; Location; Particles (particulate matter); Polycyclic aromatic hydrocarbons; Principal component analysis; aromatic compound; benz[a]anthracene; dichlomethane; organic compound; polycyclic aromatic hydrocarbon; unclassified drug; polycyclic aromatic hydrocarbon; Atmospheric pressure photo ionization; Fourier transform ion cyclotron resonance mass spectrometry; Fourier-transform ion cyclotron resonance mass spectrometry; FT-ICR MS; Gaschromatography-mass spectrometry; Mass spectrometry data; Particulate Matter; Polycyclic aromatic hydrocarbon/NONPAH ratio; Principal-component analysis; Tianjin; aerosol; anthropogenic source; gas chromatography; mass spectrometry; PAH; particulate matter; principal component analysis; aerosol; Article; atmospheric pressure; chemical analysis; chemometric analysis; China; combustion; controlled study; data processing; fourier transform ion cyclotron resonance mass spectrometry; geographic distribution; ionization; mass fragmentography; particulate matter; principal component analysis; seasonal variation; South Korea; traffic pollution; aerosol; air pollutant; environmental monitoring; mass fragmentography; mass spectrometry; particulate matter; season; Mass spectrometry | English | 2022 | 2022-01-20 | 10.1016/j.scitotenv.2021.150230 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effects of face shield on an emitter during a cough process: A large-eddy simulation study | Face shield is a common personal protection equipment for pandemic. In the present work, three-dimensional computational fluid dynamic (CFD) method is used to simulate a cough jet from an emitter who wears a face shield. A realistic manikin model with a simplified mouth cavity is employed. A large eddy simulation with a dynamic structure subgrid scale model is applied to model the turbulence. An Eulerian-Lagrangian approach is adopted to model the two-phase flows, with which the droplets are represented by a cloud of particles. The droplet breakup, evaporation, dispersion, drag force, and wall impingement are considered in this model. An inlet velocity profile that is based on a variable mouth opening area is considered. Special attentions have been put the vortex structure and droplet re-distribution induced by the face shield. It is found that the multiple vortices are formed when the cough jet impinges on the face shield. Some droplets move backward and others move downward after the impinging. It is also found that a small modification of the face shield significantly modifies the flow field and droplet distribution. We conclude that face shield significantly reduces the risk factor in the front of the emitter, meanwhile the risk factor in the back of the emitter increases. When the receiver standing in front of the emitter is shorter than the emitter, the risk is still very high. More attentions should be paid on the design of the face field, clothes cleaning and floor cleaning of the emitters with face shields. Based on the predicted droplet trajectory, a conceptual model for droplet flux is proposed for the scenario with the face shield. | Ge, Haiwen; Zhao, Peng; Choi, Sanghun; Deng, Teng; Feng, Yaning; Cui, Xinguang | Texas Tech Univ, Dept Mech Engn, Lubbock, TX 79409 USA; Univ Tennessee, UT Space Inst, Dept Mech Aerosp & Biomed Engn, Knoxville, TN USA; Kyungpook Natl Univ, Sch Mech Engn, Daegu, South Korea; Huazhong Univ Sci & Technol, Sch Aerosp Engn, Wuhan, Peoples R China | Zhao, Peng/H-9028-2019; Choi, Sanghun/AGS-7430-2022; Ge, Hai-Wen/R-1604-2018; Ge, Haiwen/R-1604-2018 | 14421143900; 57915484600; 55847101000; 57577730800; 57222044936; 50261346800 | xinguang_cui@hust.edu.cn; | SCIENCE OF THE TOTAL ENVIRONMENT | SCI TOTAL ENVIRON | 0048-9697 | 1879-1026 | 831 | SCIE | ENVIRONMENTAL SCIENCES | 2022 | 9.8 | 9.3 | 0.39 | 2025-06-25 | 5 | 8 | Face shield; Respiratory droplet; Cough jet; CFD; Large-eddy simulation; Droplet-laden cough jets | PARTICLE DEPOSITION; CAVITATING FLOW; DROPLETS; SPREAD | CFD; Cough jet; Droplet-laden cough jets; Face shield; Large-eddy simulation; Respiratory droplet | Cough; COVID-19; Humans; Pandemics; Personal Protective Equipment; Protective Devices; Drag; Lagrange multipliers; Large eddy simulation; Two phase flow; Vortex flow; Computational fluid dynamics methods; Cough jet; Droplet-laden cough jet; Face shield; Large-eddy simulations; Personal protection equipments; Respiratory droplet; Risk factors; Simulation studies; Three dimensional computational fluid dynamics; computational fluid dynamics; droplet; jet flow; large eddy simulation; turbulence; two phase flow; vortex; algorithm; Article; cleaning; coughing; dispersion; dynamics; evaporation; human; mouth cavity; pandemic; respiratory droplets and aerosols; simulation; virus transmission; protective equipment; Computational fluid dynamics | English | 2022 | 2022-07-20 | 10.1016/j.scitotenv.2022.154856 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluation of potential toxicity of polyethylene microplastics on human derived cell lines | Microplastics bare of major concern for environmental conservation and animal welfare in recent years as its use has increased tremendously. Polyethylene microplastics (PE-MPs) are the most common microplastics and could get exposed to humans via different routes with oral>inhalation>dermal. Internalization of MPs through epithelial tissue could expose MPs to various cells such as dendritic cells, macrophages/monocytes, and/or T cells. In this study, we aimed at identifying the effects of two different sized (30.5 +/- 10.5 and 6.2 +/- 2.0 mu m) PE-MPs on different human cell lines representing different tissues or cells that get exposed to MPs directly or indirectly. Six cell lines were cultured with different concentrations of PE-MPs and cell viability, intracellular reactive oxygen species (ROS), nitric oxide (NO), and cytokines were measured. PE-MPs did not substantially lower the cell viability of cells however highest concentration (1000 mu g/mL) of both sized MPs slightly reduced cell viability in intestinal epithelial Caco-2 and lung epithelial A549 cells. Both sized PE-MPs induced higher NO in all the cell lines and upregulation of ROS generation was demonstrated at THP-1, Jurkat, and U937 immune cell lines. A pro-inflammatory cytokine response was seen in HaCaT keratinocyte cells when cultured with PE-MPs whereas the opposite effect was observed in THP-1 and U937 cells except with THP-1 cells cultured with larger-sized MPs. We found that the PE-MPs do not have the same effects on all kinds of cells and tissues exposed and the immune modulation is not necessarily inflammatory. Thus, this study gives insight into why more detailed studies focused on exposure routes and organ-specific effects of different MPs need to be carried out. | Gautam, Ravi; Jo, JiHun; Acharya, Manju; Maharjan, Anju; Lee, DaEun; Bahadur, K. C. Pramod; Kim, ChangYul; Kim, KilSoo; Kim, HyoungAh; Heo, Yong | Daegu Catholic Univ, Coll Bio & Med Sci, Dept occupat Hlth, Gyongsan 38430, South Korea; Daegu Catholic Univ, Grad Sch Dept Toxicol, Gyongsan 38430, South Korea; Daegu Gyeongbuk Med Innovat Ctr, Preclin Res Ctr, Daegu 41061, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Catholic Univ Korea, Coll Med, Dept Prevent Med, Seoul 06591, South Korea; Daegu Catholic Univ, Coll Bio & Med Sci, Dept Occupat Hlth, 13-13 Hayang Ro, Gyongsan 38430, Gyeongbuk, South Korea; Childrens Hosp Philadelphia, Philadelphia, PA USA | KC, Remant/AAT-8069-2020; Gautam, Ravi/AHA-0753-2022 | 57193066897; 57212005375; 57207357125; 57210824805; 57241720300; 57261174100; 56590694800; 35272034300; 56507727300; 36087239900 | gautamr@chop.edu;cykim0813@cu.ac.kr;kskim728@knu.ac.kr;kimha@catholic.ac.kr;yheo@cu.ac.kr; | SCIENCE OF THE TOTAL ENVIRONMENT | SCI TOTAL ENVIRON | 0048-9697 | 1879-1026 | 838 | SCIE | ENVIRONMENTAL SCIENCES | 2022 | 9.8 | 9.3 | 7.04 | 2025-06-25 | 119 | 130 | Microplastics; Polyethylene; Reactive oxygen species; Nitric oxide | NITRIC-OXIDE; OXIDATIVE STRESS; AIRBORNE MICROPLASTICS; CYTOKINE EXPRESSION; IN-VITRO; NANOPARTICLES; INDUCTION; SIZE; NANOPLASTICS; INFLAMMATION | Microplastics; Nitric oxide; Polyethylene; Proinflammatory cytokines; Reactive oxygen species | Animals; Caco-2 Cells; Humans; Microplastics; Plastics; Polyethylene; Reactive Oxygen Species; Water Pollutants, Chemical; Cell culture; Cells; Histology; Nitric oxide; Oxygen; Tissue; cytokine; microplastic; nitric oxide; polyethylene; reactive oxygen metabolite; plastic; polyethylene; reactive oxygen metabolite; Animal welfare; Cell lines; Cell viability; Environmental conservation; Epithelial tissue; Exposed to; Microplastics; Proinflammatory cytokines; Reactive oxygen species; THP-1 cells; cell organelle; nitric oxide; plastic; polymer; reactive oxygen species; toxicity; Article; Caco-2 cell line; cell viability; controlled study; dendritic cell; environmental protection; human; human cell; immunocompetent cell; immunomodulation; intestine epithelium cell; Jurkat cell line; macrophage; monocyte; pollution; T lymphocyte; toxicity; U-937 cell line; animal; water pollutant; Polyethylenes | English | 2022 | 2022-09-10 | 10.1016/j.scitotenv.2022.156089 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Hazardous elements present in coal nanoparticles in a Caribbean port region in Colombia | Scientific works examining coal-derived nanoparticles (NPs) containing potentially toxic elements (PTEs) confined in marine suspended sediments (MSSs) in port regions worldwide is an understudied topic, despite the fact that coal NPs have tremendous negative impacts on marine estuaries. The general objective of this study is to analyze the NP levels of coal, including PTEs, contained within MSSs in the general vicinity of the largest Caribbean port in Colombia. The morphology, size, chemical composition, and agglomeration states of NPs within MSSs of the sampled beaches were calculated through modern electron microscopy. The methodology used to detect chemical elements, unfortunately with EDS, it is not possible to precisely specify the chemical elements of low atomic weight (e.g. H, O, F, etc.) Therefore, with the EDS available today, it is only possible to have an idea of the chemical composition of each detected particle. Thus, it was possible to obtain the average frequency of the chemical elements identified in the 23 analyzed sampling points. Through the results, more than one thousand particles were detected in the most abundant phases, thus, the most frequent particles in the results of this manuscript were described. Sample point 8, located closest to the coal export port, had a higher concentration of nano-toxic elements (Al, Fe, Si, K, Mg, K) most concerning for human health in addition to being harmful to marine life. This study suggests that public policies dealing with MSS pollution need to be discussed by public managers to avoid further and sustained environmental degradation. The need to create projects will subsidize legacy liabilities generated by coal in seaports in other regions of the world. | Neckel, Alcindo; Osorio-Martinez, Jorge; Pinto, Diana; Bodah, Brian W.; Adelodun, Bashir; Silva, Luis F. O. | IMED, Fac Merid, 304, BR-99070220 Passo Fundo, RS, Brazil; Univ Costa, Dept Civil & Environm Engn, Calle 58 55-66, Barranquilla 080002, Colombia; Fed Univ St Maria UFSM, Chem Engn Dept, 1000 Roraima Ave, BR-97105900 Santa Maria, RS, Brazil; Yakima Valley Coll, Workforce Educ & Appl Baccalaureate Programs, South16th Ave & Nob Hill Blvd, Yakima, WA 98902 USA; Thaines & Bodah Ctr Educ & Dev, 840 South Meadowlark Lane, Othello, WA 99344 USA; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin 240103, Nigeria; Kyungpook Natl Univ, Dept Agr Civil Engn, Daegu 41566, South Korea | ; Silva, Luis/S-9681-2017; Pinto, Diana/D-5446-2015; Neckel, Alcindo/AAN-4623-2020; Adelodun, Bashir/O-2941-2018 | 56973887600; 57222401995; 57195677095; 56586983300; 57193774482; 57192545865 | alcindo.neckel@imed.edu.br;lsilva8@cuc.edu.co; | SCIENCE OF THE TOTAL ENVIRONMENT | SCI TOTAL ENVIRON | 0048-9697 | 1879-1026 | 838 | SCIE | ENVIRONMENTAL SCIENCES | 2022 | 9.8 | 9.3 | 0.44 | 2025-06-25 | 8 | 8 | Export of coal; Nanoparticles; Contamination risks; Marine pollution; Future public policies | HEAVY-METALS; SEDIMENTS; POLLUTION; WATER; RIVER; TRACE; CONTAMINATION; NANOMINERALS; REJECTS; IMPACT | Contamination risks; Export of coal; Future public policies; Marine pollution; Nanoparticles | Coal; Colombia; Environmental Monitoring; Geologic Sediments; Humans; Nanoparticles; Colombia; Chemical analysis; Coal; Degradation; Marine pollution; Particle size analysis; Public policy; Suspended sediments; aluminum; aluminum hydroxide; aluminum sulfate; arsenic; arsenopyrite; carbon nanotube; coal nanoparticle; ferric hydroxide; fullerene; iron; lead sulfide; magnesium; nanoparticle; potassium; potentially toxic element; pyrite; pyrrhotite; silicon; toxic substance; unclassified drug; coal; nanoparticle; Atomic weights; Average frequency; Chemical compositions; Colombia; Contamination risks; Export of coal; Future public policy; Hazardous elements; Potentially toxic elements; Sampling points; coal seam; coal supply; export; marine pollution; nanoparticle; risk assessment; suspended sediment; analytic method; Article; Caribbean; chemical composition; coal mining; Colombia; contamination; dangerous goods; electron microscopy; energy dispersive X ray spectroscopy; field emission scanning electron microscopy; high resolution transmission electron microscopy; inductively coupled plasma mass spectrometry; marine suspended sediment; modern electron microscopy; morphology; nonhuman; sampling; sea pollution; sediment; X ray diffraction; chemistry; environmental monitoring; human; procedures; sediment; Nanoparticles | English | 2022 | 2022-09-10 | 10.1016/j.scitotenv.2022.156363 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Microglial phagocytosis of polystyrene microplastics results in immune alteration and apoptosis in vitro and in vivo | The remarkable increase in plastic usage and widespread microplastic (MP) pollution has emerged as a substantial concern today. Many recent studies have revealed MPs as potentially hazardous substances in mammals. Despite several reports on the impact of small MPs in the brain and behaviors in aquatic animals, it is still unclear how small MPs affect the brain and its underlying cellular physiology in terrestrial animals. In this study, we investigated the accumulation of polystyrene MPs (PS-MPs) in mouse brain after oral treatment using three types of fluorescent PS-MPs of different sizes (0.2,2 and 10 mu m). We found that PS-MPs were deposited in microglial cells of the brain. Following differential treatment of PS-MPs in human microglial HMC-3 cells, we identified changes in cellular morphology, immune responses, and microglial apoptosis induced by phagocytosis of 0.2 and 2 mu m PS-MPs. By analyzing the PS-MP-treated HMC-3 cell transcriptome, we showed that PS-MPs treatment altered the expression of clusters of immune response genes, immunoglobulins, and several related microRNAs. In addition, we confirmed alterations in microglial differentiation marker expression with the activation of NF KB, pro-inflammatory cytokines and apoptotic markers in PS-MP-treated human microglial cells and in mouse brain. Our findings suggest a potential risk of small PS-MPs in microglial immune activation, which leads to microglial apoptosis in murine and human brains. (c) 2021 Published by Elsevier B.V. | Kwon, Wookbong; Kim, Daehwan; Kim, Hee-Yeon; Jeong, Sang Won; Lee, Se-Guen; Kim, Hyun-Chul; Lee, Young-Jae; Kwon, Mi Kyung; Hwang, Jun-Seong; Han, Jee Eun; Park, Jin-Kyu; Lee, Sung-Jun; Choi, Seong-Kyoon | DGIST, Div Biotechnol, Daegu 42988, South Korea; DGIST, Core Prot Resources Ctr, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea | 57139843600; 57212363780; 58368914700; 57037609100; 8673372800; 57214326521; 57199021765; 57150067700; 57189033977; 57214671240; 35213723500; 57207065225; 55505432500 | schrisj@dgist.ac.kr;cskbest@dgist.ac.kr; | SCIENCE OF THE TOTAL ENVIRONMENT | SCI TOTAL ENVIRON | 0048-9697 | 1879-1026 | 807 | SCIE | ENVIRONMENTAL SCIENCES | 2022 | 9.8 | 9.3 | 7.65 | 2025-06-25 | 138 | 140 | Polystyrene microplastics; Mouse; Brain; Microglia; Immune response; Apoptosis | Apoptosis; Brain; Immune response; Microglia; Mouse; Polystyrene microplastics | Animals; Apoptosis; Mice; Microglia; Microplastics; Phagocytosis; Plastics; Polystyrenes; Mammalia; Murinae; Antigen-antibody reactions; Chemical activation; Immune system; Mammals; Microplastic; Polystyrenes; Toxicity; antigen; baculoviral IAP repeat containing protein 5; beta actin; caspase 3; caspase 8; CD16 antigen; CD206 antigen; CD68 antigen; cytokine; Iba1 protein; immunoglobulin; immunoglobulin enhancer binding protein; interleukin 1beta; membrane protein; microplastic; microRNA; monocyte chemotactic protein 1; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; polystyrene; protein Bax; STAT3 protein; transcriptome; transforming growth factor beta; unclassified drug; plastic; polystyrene derivative; Hazardous substances; Immune response; In-vitro; Microglia; Microglial cells; Microplastics; Mouse; Mouse brain; Polystyrene microplastic; Vitro and in vivo; apoptosis; brain; cell; gene expression; immune response; mammal; plastic waste; protein; risk assessment; terrestrial ecosystem; animal experiment; animal tissue; apoptosis; Article; bioaccumulation; cell cycle; cell phagocytosis; cell structure; cell viability; controlled study; gene; gene expression; human; human cell; immune response; in vitro study; in vivo study; infant; live cell imaging; microglia; mouse; nerve cell differentiation; nonhuman; real time polymerase chain reaction; Western blotting; animal; apoptosis; microglia; phagocytosis; Cell death | English | 2022 | 2022-02-10 | 10.1016/j.scitotenv.2021.150817 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Optical Cavity Manipulation and Nonlinear UV Molecular Spectroscopy of Conical Intersections in Pyrazine | Optical cavities provide a versatile platform for manipulating the excited-state dynamics of molecules via stronglight-matter coupling. We employ optical absorption and two-multidimensional electronic spectroscopy simulations to investigatethe effect of optical cavity coupling in the nonadiabatic dynamics ofphotoexcited pyrazine. We observe the emergence of a novelpolaritonic conical intersection (PCI) between the electronic darkstate and photonic surfaces as the cavity frequency is tuned. The PCIcould significantly change the nonadiabatic dynamics of pyrazine bydoubling the decay rate constant of the S2state population. Moreover, the absorption spectrum and excited-state dynamics could besystematically manipulated by tuning the strong light-matter interaction, e.g., the cavity frequency and cavity coupling strength. We propose that a tunable optical cavity-molecule system may provide promising approaches for manipulating the photophysical properties of molecules | Cho, Daeheum; Gu, Bing; Mukamel, Shaul | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea; Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA; Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA | Cho, Daeheum/D-9235-2018 | 55263218400; 55587749300; 35473361700 | daeheumc@knu.ac.kr;bingg@uci.edu;smukamel@uci.edu; | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | J AM CHEM SOC | 0002-7863 | 1520-5126 | 144 | 17 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2022 | 15 | 9.3 | 0.76 | 2025-06-25 | 13 | 13 | ENERGY-TRANSFER; DYNAMICS; CHEMISTRY | Absorption spectroscopy; Decay (organic); Excited states; Light absorption; Molecular spectroscopy; Rate constants; pyrazine; Cavity frequency; Conical intersection; Dark state; Electronic spectroscopy; Excited-state dynamics; Light-matter coupling; Non-adiabatic dynamics; Optical cavities; Polaritonics; Pyrazines; absorption; Article; concentration (parameter); electric field; electron; reaction analysis; surface property; ultraviolet spectroscopy; Molecules | English | 2022 | 2022-05-04 | 10.1021/jacs.2c00921 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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