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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Pharmacokinetics and Intestinal Metabolism of Compound K in Rats and Mice | We aimed to investigate the plasma concentration, tissue distribution, and elimination of compound K following the intravenous administration of compound K (2 mg/kg) in rats and mice. The plasma concentrations of compound K in mice were much higher (about five-fold) than those in rats. In both rats and mice, compound K was mainly distributed in the liver and underwent biliary excretion. There was 28.4% fecal recovery of compound K in mice and 13.8% in rats, whereas its renal recovery was less than 0.1% in both rats and mice. Relative quantification of compound K and its metabolite protopanaxadiol (PPD) in rat bile and intestinal feces indicated that the metabolism from compound K into PPD occurred in the intestine but not in the plasma. Therefore, PPD detected in the plasma samples could have been absorbed from the intestine after metabolism in control rats, while PPD could not be detected in the plasma samples from bile duct cannulated rats. In conclusion, mice and rats shared common features such as exclusive liver distribution, major excretion pathway via biliary route, and intestinal metabolism to PPD. However, there were significant differences between rats and mice in the plasma concentrations of compound K and the fecal recovery of compound K and PPD. | Jeon, Ji-Hyeon; Kang, Bitna; Lee, Sowon; Jin, Sojeong; Choi, Min-Koo; Song, Im-Sook | Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Daegu 41566, South Korea; Dankook Univ, Coll Pharm, Cheonan 31116, South Korea | 57204685946; 57202867077; 57204650133; 57204690167; 8695781400; 7201564500 | kei7016@naver.com;qlcska8520@naver.com;okjin917@hanmail.net;astraea327@naver.com;minkoochoi@dankook.ac.kr;isssong@knu.ac.kr; | PHARMACEUTICS | PHARMACEUTICS | 1999-4923 | 12 | 2 | SCIE | PHARMACOLOGY & PHARMACY | 2020 | 6.321 | 10.3 | 0.79 | 2025-06-25 | 12 | 13 | compound K; protopanaxadiol (PPD); pharmacokinetics; biliary excretion; intestinal metabolism | ORAL BIOAVAILABILITY; MIXED MICELLES; GINSENOSIDES; 20(S)-PROTOPANAXADIOL; BIOTRANSFORMATION; ABSORPTION; PIPERINE; EXTRACT | Biliary excretion; Compound K; Intestinal metabolism; Pharmacokinetics; Protopanaxadiol (PPD) | compound K; ginsenoside; protopanaxadiol; unclassified drug; animal experiment; animal tissue; Article; biliary excretion; controlled study; drug blood level; drug distribution; drug elimination; drug excretion; drug feces level; drug metabolism; drug urine level; intestine; male; mouse; nonhuman; rat; tissue distribution | English | 2020 | 2020-02 | 10.3390/pharmaceutics12020129 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Recent progress in controlled nano/micro cracking as an alternative nano-patterning method for functional applications | Generally, cracking occurs for many reasons connected to uncertainties and to the non-uniformity resulting from intrinsic deficiencies in materials or the non-linearity of applied external (thermal, mechanical,etc.) stresses. However, recently, an increased level of effort has gone into analyzing the phenomenon of cracking and also into methods for controlling it. Sophisticated manipulation of cracking has yielded various cutting-edge technologies such as transparent conductors, mechanical sensors, microfluidics, and energy devices. In this paper, we present some of the recent progress that has been made in controlling cracking by giving an overview of the fabrication methods and working mechanisms used for various mediums. In addition, we discuss recent progress in the various applications of methods that use controlled cracking as an alternative to patterning tools. | Jung, Jinwook; Kim, Kyun Kyu; Suh, Young. D.; Hong, Sukjoon; Yeo, Junyeob; Ko, Seung Hwan | Seoul Natl Univ, Dept Mech Engn, Appl Nano & Thermal Sci Lab, 1 Gwanak Ro, Seoul 08826, South Korea; Kyungpook Natl Univ, Dept Phys, Novel Appl Nano Opt Lab, 80 Daehak Ro, Daegu 41566, South Korea; Hanyang Univ, Dept Mech Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea; Seoul Natl Univ, Inst Adv Machines & Design IAMD, Seoul 08826, South Korea; Seoul Natl Univ, Inst Engn Res, Seoul 08826, South Korea | Yeo, Junyeob/I-1287-2013; Ko, Seung Hwan/B-5448-2008; Ko, Seung Hwan/B-5448-2008; Kim, Kyun Kyu/GNP-5638-2022 | 57193111722; 57736986100; 56223230400; 34973077200; 58692645200; 8699527700 | junyeob@knu.ac.kr;maxko@snu.ac.kr; | NANOSCALE HORIZONS | NANOSCALE HORIZ | 2055-6756 | 2055-6764 | 5 | 7 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 10.989 | 10.3 | 0.25 | 2025-06-25 | 23 | 24 | ENVIRONMENTAL-STRESS CRACKING; STRAIN SENSORS; LARGE-AREA; TRANSPARENT; INITIATION; FABRICATION; FILMS; POLYETHYLENE; PROPAGATION; ELECTRODES | Nanosensors; Cutting edge technology; Fabrication method; Functional applications; Mechanical sensors; Non-uniformities; Patterning tools; Transparent conductors; Working mechanisms; review; Cracks | English | 2020 | 2020-07-01 | 10.1039/d0nh00241k | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Correction | Recent progress in controlled nano/micro cracking as an alternative nano-patterning method for functional applications (vol 74, pg 861, 2020) | Jung, Jinwook; Kim, Kyun Kyu; Suh, Young. D.; Hong, Sukjoon; Yeo, Junyeob; Ko, Seung Hwan | Seoul Natl Univ, Dept Mech Engn, Appl Nano & Thermal Sci Lab, 1 Gwanak Ro, Seoul 08826, South Korea; Hanyang Univ, Dept Mech Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Phys, Novel Appl Nano Opt Lab, 80 Daehak Ro, Daegu 41566, South Korea; Seoul Natl Univ, Inst Adv Machines & Design IAMD, Seoul 08826, South Korea; Seoul Natl Univ, Inst Engn Res, Seoul 08826, South Korea | Yeo, Junyeob/I-1287-2013; Kim, Kyun Kyu/GNP-5638-2022; Ko, Seung Hwan/B-5448-2008; Ko, Seung Hwan/B-5448-2008 | 57193111722; 57736986100; 56223230400; 34973077200; 58692645200; 8699527700 | junyeob@knu.ac.kr;maxko@snu.ac.kr; | NANOSCALE HORIZONS | NANOSCALE HORIZ | 2055-6756 | 2055-6764 | 5 | 7 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 10.989 | 10.3 | 0 | 2025-06-25 | 0 | 0 | erratum | English | 2020 | 2020-07-01 | 10.1039/d0nh90031a | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Research Note: Association of temporal expression of myostatin with hypertrophic muscle growth in different Japanese quail lines | Myostatin (MSTN) negatively regulates in muscle growth and development. Among alternative splicing isoforms of avian MSTN, MSTN-A has anti-myogenic activities and MSTN-B functions as a pro-myogenic factor. In this study, different lines of Japanese quail were used: a random bred control (RBC) and a heavy weight (HW) quail line with muscle hypertrophy. The objectives of the current study are to compare temporal expression of the MSTN isoforms in pectoralis major muscle (PM) between 2 quail lines and to relate MSTN expression with temporal changes in muscle growth and total amounts of DNA in PM. Gains of body weight (BW) and PM weight were greater until post -hatch day (D) 28 (P < 0.001), and the fold increases in total DNA contents of PM were greater in the HW line compared with the RBC line during D7 to D28 (P < 0.05). PCR analysis showed that MSTN-A expression was greater at 14 D (E14) of embryonic age (P < 0.01), D7 (P = 0.052), and D14 (P < 0.01) in the RBC line compared with the HW line. At D28 and D75, expression of MSTN-A was greater in the HW line compared with the RBC line (P < 0.05). MSTN-B expression was barely detectable from E14 to D14 and measurable from D28 to D75 in the muscle of both lines. Ratios of the MSTN-B/-A form ranging from 0.15 to 0.29 indicate a minor expression of the B form. Taken together, the lesser expression levels of MSTN-A at E14, D7, and D14 are associated with the fast growth of PM, and greater MSTN-A expression at D28 and D75 are associated with a slowdown of PM growth in the HW line. These data indicate a negative association of MSTN expression with PM growth and provide a scientific basis for potential usage of MSTN expression as a selection marker for greater muscle growth in poultry. | Kim, Dong-Hwan; Choi, Young Min; Suh, Yeunsu; Shin, Sangsu; Lee, Joonbum; Hwang, Seongsoo; Lee, Kichoon | Ohio State Univ, Dept Anim Sci, Columbus, OH 43210 USA; Kyungpook Natl Univ, Dept Anim Sci, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Anim Biotechnol, Sangju 37224, South Korea; Ohio State Univ, Interdisciplinary PhD Program Nutr, Columbus, OH 43210 USA; Natl Inst Anim Sci, RDA, Anim Biotechnol Div, Jeonbuk 55365, South Korea | ; Kim, Donghwan/LRC-0840-2024; Lee, Kichoon/G-2234-2012; Choi, Young/J-6027-2014 | 56621562800; 57226673843; 26430117900; 55490360000; 57194466213; 8725163200; 14123395400 | lee.2626@osu.edu; | POULTRY SCIENCE | POULTRY SCI | 0032-5791 | 1525-3171 | 99 | 6 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE | 2020 | 3.352 | 10.3 | 1.09 | 2025-06-25 | 9 | 9 | myostatin; hypertrophy; HW quail; muscle development; MSTN isoforms | ADIPOSE; PERFORMANCE; SELECTION; MUTATION; CLONING; WEIGHT; ACID; MYOD; MASS | HW quail; hypertrophy; MSTN isoforms; muscle development; myostatin | English | 2020 | 2020-06 | 10.1016/j.psj.2019.12.069 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Smart Microneedles with Porous Polymer Layer for Glucose-Responsive Insulin Delivery | A closed-loop system imitating the function of pancreatic cells, connected to microneedles (MNs) that automatically "release" insulin in response to the blood glucose (BG) levels would be highly satisfactory for improving the quality of life and health for diabetes patients. This paper describes an easy, fast and simple technique of coating a porous polymer layer on stainless steel (SS) MNs that release insulin in a glucose-responsive fashion. It was fabricated by sealing insulin, sodium bicarbonate (a pH-sensitive element [NaHCO3]) and glucose oxidase (glucose-specific enzymes [GOx]) into the pores of a porous polymer coating. Glucose can passively diffuse into the pores and become oxidized to gluconic acid by GOx, thereby causing a decrease in local pH. The subsequent reaction of protons with NaHCO(3)forms carbon dioxide (CO2) which creates pressure inside the pores, thereby rupturing the thin polymer film and releasing the encapsulated insulin. Field emission scanning electron microscopy (FE-SEM) images displayed that upon the exposure of MNs to glucose-free phosphate buffer saline (PBS) with pH 7.4, the pores of the porous MNs were closed, while in MNs exposed to a hyperglycemic glucose level, the pores were opened and the thin film burst. These MNs demonstrated both in vitro (in porcine skin and PBS) and in vivo (in diabetic rats) glucose-mediated insulin release under hyperglycemic conditions with rapid responsiveness. This study validated that the release of insulin from porous MNs was effectively correlated with glucose concentration. | Ullah, Asad; Choi, Hye Jin; Jang, Mijin; An, Sanghyun; Kim, Gyu Man | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 41061, South Korea | 56820305400; 57203969417; 57222997201; 57102583100; 55664733000 | sasadullah84@gmail.com;gbksj5@naver.com;mijin22@dgmif.re.kr;ash4235@dgmif.re.kr;gyuman.kim@knu.ac.kr; | PHARMACEUTICS | PHARMACEUTICS | 1999-4923 | 12 | 7 | SCIE | PHARMACOLOGY & PHARMACY | 2020 | 6.321 | 10.3 | 2.77 | 2025-06-25 | 36 | 39 | glucose-responsive; insulin delivery; porous coated-microneedles; sodium bicarbonate | DISSOLVING MICRONEEDLES; DIABETES-MELLITUS; RELEASE; MICROSPHERES; PATCHES; ARRAYS; PLGA; DRUGS; MODEL | Glucose-responsive; Insulin delivery; Porous coated-microneedles; Sodium bicarbonate | bicarbonate; carbon dioxide; gluconic acid; glucose; glucose oxidase; insulin; phosphate buffered saline; porous polymer; proton; stainless steel; animal experiment; animal model; animal tissue; Article; concentration (parameter); controlled drug release; controlled study; diabetes mellitus; drug delivery system; field emission scanning electron microscopy; glucose blood level; hyperglycemia; in vitro study; in vivo study; insulin release; male; nonhuman; pH; pig; rat; skin; streptozotocin-induced diabetes mellitus; thin film (procedure); treatment response | English | 2020 | 2020-07 | 10.3390/pharmaceutics12070606 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Strong and Selective Inhibitory Effects of the Biflavonoid Selamariscina A against CYP2C8 and CYP2C9 Enzyme Activities in Human Liver Microsomes | Like flavonoids, biflavonoids, dimeric flavonoids, and polyphenolic plant secondary metabolites have antioxidant, antibacterial, antiviral, anti-inflammatory, and anti-cancer properties. However, there is limited data on their effects on cytochrome P450 (P450) and uridine 5 '-diphosphoglucuronosyl transferase (UGT) enzyme activities. In this study we evaluate the inhibitory potential of five biflavonoids against nine P450 activities (P450s1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A) in human liver microsomes (HLMs) using cocktail incubation and liquid chromatography-tandem mass spectrometry (LC-MS/MS). The most strongly inhibited P450 activity was CYP2C8-mediated amodiaquine N-dealkylation with IC50 ranges of 0.019 similar to 0.123 mu M. In addition, the biflavonoids-selamariscina A, amentoflavone, robustaflavone, cupressuflavone, and taiwaniaflavone-noncompetitively inhibited CYP2C8 activity with respective K-i values of 0.018, 0.083, 0.084, 0.103, and 0.142 mu M. As selamariscina A showed the strongest effects, we then evaluated it against six UGT isoforms, where it showed weaker inhibition (UGTs1A1, 1A3, 1A4, 1A6, 1A9, and 2B7, IC50 > 1.7 mu M). Returning to the P450 activities, selamariscina A inhibited CYP2C9-mediated diclofenac hydroxylation and tolbutamide hydroxylation with respective K-i values of 0.032 and 0.065 mu M in a competitive and noncompetitive manner. However, it only weakly inhibited CYP1A2, CYP2B6, and CYP3A with respective K-i values of 3.1, 7.9, and 4.5 mu M. We conclude that selamariscina A has selective and strong inhibitory effects on the CYP2C8 and CYP2C9 isoforms. This information might be useful in predicting herb-drug interaction potential between biflavonoids and co-administered drugs mainly metabolized by CYP2C8 and CYP2C9. In addition, selamariscina A might be used as a strong CYP2C8 and CYP2C9 inhibitor in P450 reaction-phenotyping studies to identify drug-metabolizing enzymes responsible for the metabolism of new chemicals. | Park, So-Young; Phi-Hung Nguyen; Kim, Gahyun; Jang, Su-Nyeong; Lee, Ga-Hyun; Phuc, Nguyen Minh; Wu, Zhexue; Liu, Kwang-Hyeon | Kyungpook Natl Univ, BK21 Plus KNU Multiom Based Creat Drug Res Team, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Vietnam Acad Sci & Technol, Inst Nat Prod Chem, 18 Hoang Quoc Viet, Hanoi 100000, Vietnam; Vietnam Hightech Med & Pharmaceut JSC, Grp 11 Quang Minh Town, Hanoi 100000, Vietnam | 57211630074; 35185458300; 57216547646; 57211630666; 57202873792; 56522749600; 55523767300; 55768214700 | soyoung561021@gmail.com;nguyenphihung1002@gmail.com;hyunlove9137@naver.com;wts1424@naver.com;lgh2710@gmail.com;phucnguyen0606@gmail.com;wuzhexue527@gmail.com;dstlkh@knu.ac.kr; | PHARMACEUTICS | PHARMACEUTICS | 1999-4923 | 12 | 4 | SCIE | PHARMACOLOGY & PHARMACY | 2020 | 6.321 | 10.3 | 1.88 | 2025-06-25 | 19 | 20 | biflavonoid; cytochrome P450; drug interactions; selamariscina A; uridine 5 '-diphosphoglucuronosyl transferase | DRUG-DRUG INTERACTION; IN-VITRO; SELAGINELLA-TAMARISCINA; DEPENDENT INHIBITION; METABOLISM; FLAVONOIDS; RAT; BIOAVAILABILITY; POLYPHENOLS; NARINGENIN | Biflavonoid; Cytochrome P450; Drug interactions; Selamariscina A; Uridine 5'- diphosphoglucuronosyl transferase | amentoflavone; biflavonoid; cupressuflavone; cytochrome P450; cytochrome P450 1A2; cytochrome P450 2A6; cytochrome P450 2B6; cytochrome P450 2C19; cytochrome P450 2C8; cytochrome P450 2C9; cytochrome P450 2D6; cytochrome P450 2E1; cytochrome P450 3A; diclofenac; glucuronosyltransferase 1A1; glucuronosyltransferase 1A3; glucuronosyltransferase 1A4; glucuronosyltransferase 1A6; glucuronosyltransferase 1A9; glucuronosyltransferase 2B7; montelukast; robustaflavone; selamariscina A; taiwaniaflavone; tolbutamide; unclassified drug; Article; chemical reaction; controlled study; dealkylation; drug activity; drug selectivity; drug structure; enzyme inhibition; human; human cell; IC50; inhibition kinetics; liquid chromatography-mass spectrometry; liver microsome; molecular dynamics; phenotype; Selaginella tamariscina | English | 2020 | 2020-04 | 10.3390/pharmaceutics12040343 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The Development and Validation of a Novel "Dual Cocktail" Probe for Cytochrome P450s and Transporter Functions to Evaluate Pharmacokinetic Drug-Drug and Herb-Drug Interactions | This study was designed to develop and validate a 10 probe drug cocktail named "Dual Cocktail", composed of caffeine (Cyp1a2 in rat and CYP1A2 in human, 1 mg/kg), diclofenac (Cyp2c11 in rat and CYP2C9 in human, 2 mg/kg), omeprazole (Cyp2c11 in rat and CYP2C19 in human, 2 mg/kg), dextromethorphan (Cyp2d2 in rat and CYP2D6 in human, 10 mg/kg), nifedipine (Cyp3a1 in rat and CYP3A4 in human, 0.5 mg/kg), metformin (Oct1/2 in rat and OCT1/2 in human, 0.5 mg/kg), furosemide (Oat1/3 in rat and OAT1/3 in human, 0.1 mg/kg), valsartan (Oatp2 in rat and OATP1B1/1B3 in human, 0.2 mg/kg), digoxin (P-gp in rat and human, 2 mg/kg), and methotrexate (Mrp2 in rat and MRP2 in human, 0.5 mg/kg), for the evaluation of pharmacokinetic drug-drug and herb-drug interactions through the modulation of a representative panel of CYP enzymes or transporters in rats. To ensure no interaction among the ten probe substrates, we developed a 2-step evaluation protocol. In the first step, the pharmacokinetic properties of five individual CYP probe substrates and five individual transporter substrates were compared with the pharmacokinetics of five CYP cocktail or five transporters cocktails in two groups of randomly assigned rats. Next, a pharmacokinetic comparison was conducted between the CYP or transporter cocktail group and the dual cocktail group, respectively. None of the ten comparison groups was found to be statistically significant, indicating the CYP and transporter substrate sets or dual cocktail set could be concomitantly administered in rats. The "Dual Cocktail" was further validated by assessing the metabolism of nifedipine and omeprazole, which was significantly reduced by a single oral dose of ketoconazole (10 mg/kg); however, no changes were observed in the pharmacokinetic parameters of other probe substrates. Additionally, multiple oral doses of rifampin (20 mg/kg) reduced the plasma concentrations of nifedipine and digoxin, although not any of the other substrates. In conclusion, the dual cocktail can be used to characterize potential pharmacokinetic drug-drug interactions by simultaneously monitoring the activity of multiple CYP isoforms and transporters. | Kwon, Mihwa; Jeon, Ji-Hyeon; Choi, Min-Koo; Song, Im-Sook | Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Daegu 41566, South Korea; Dankook Univ, Coll Pharm, Cheonan 31116, South Korea; Kyungpook Natl Univ, Vessel Organ Interact Res Ctr VOICE, Daegu 41566, South Korea | 55964714000; 57204685946; 8695781400; 7201564500 | mihwa_k@naver.com;kei7016@naver.com;minkoochoi@dankook.ac.kr;isssong@knu.ac.kr; | PHARMACEUTICS | PHARMACEUTICS | 1999-4923 | 12 | 10 | SCIE | PHARMACOLOGY & PHARMACY | 2020 | 6.321 | 10.3 | 0.89 | 2025-06-25 | 16 | 15 | dual cocktail; pharmacokinetic drug-drug interaction; cytochrome P450 (CYP); transporter | COMPREHENSIVE IN-VIVO; P-GLYCOPROTEIN; PANAX-GINSENG; ORAL BIOAVAILABILITY; SPECIES-DIFFERENCES; BILIARY-EXCRETION; INHIBITION; METABOLISM; KETOCONAZOLE; BLOOD | Cytochrome P450 (CYP); Dual cocktail; Pharmacokinetic drug-drug interaction; Transporter | ABC transporter subfamily B; caffeine; carrier protein; cytochrome P450; cytochrome P450 1A2; cytochrome P450 2C11; cytochrome P450 2C19; cytochrome P450 2C9; cytochrome P450 2D6; cytochrome P450 3A1; cytochrome P450 3A4; dextromethorphan; diclofenac; digoxin; furosemide; ginseng extract; ketoconazole; metformin; methotrexate; nifedipine; omeprazole; organic anion transporter 1; organic anion transporter 3; organic cation transporter 1; organic cation transporter 2; rifampicin; solute carrier organic anion transporter 1B1; solute carrier organic anion transporter 1B3; valsartan; animal experiment; area under the curve; Article; controlled study; drug blood level; drug competition; drug disposition; drug excretion; drug exposure; drug metabolism; herb drug interaction; male; maximum plasma concentration; multiple drug dose; nonhuman; protein function; rat; single drug dose | English | 2020 | 2020-10 | 10.3390/pharmaceutics12100938 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Advanced characterization of IGCC slag by automated SEM-EDS analysis | Integrated gasification combined cycle (IGCC) is a highly efficient method for producing electricity but discharges a byproduct in the form of a glassy slag, similar to other electricity generation operations. Several technologies for recycling IGCC slag have been developed thus far, although the results obtained are not promising or universally applicable. We quantitatively characterized an IGCC slag by using various testing methods, including an automated scanning electron microscopy-energy dispersive spectrometry (SEM-EDS) system, to recognize its potential for recycling. The IGCC slag did not contain free CaO, and the absence of free lime would address a concern of volumetric expansion during hydration. Automated SEM-EDS analysis revealed that approximately 98% of the IGCC slag particles consisted of calcium-rich aluminosilicate materials. Obvious differences in the concentrations of Si, Al, and Ca between the amorphous phases and the average chemical bulk were recognized. The chemical composition of the amorphous Si-Al-Ca phases was similar to that of Class C fly ash, while the average bulk composition of the IGCC slag was in between that of Class C and Class F fly ashes. Considering this discrepancy, understanding the dissolution mechanism of the reactive amorphous fraction as well as an exact assessment of the reaction products based on the role of Ca in alkali-activated materials provides a new approach for the valorization of IGCC slag. (C) 2020 Elsevier Ltd. All rights reserved. | Lee, Bokyeong; Lee, Sujeong; Kim, Byoungkwan; Choi, Hyeonggil | Kyungpook Natl Univ, Intelligent Construct Automat Ctr, Daegu 41566, South Korea; Korea Inst Geosci & Mineral Resources, Mineral Resources Res Div, Daejeon 34132, South Korea; Univ Sci & Technol, Daejeon 34113, South Korea; Kyungpook Natl Univ, Sch Architecture, Daegu 41566, South Korea | ; Kim, Byoungkwan/JTT-2760-2023; Lee, sujeong/KUD-4735-2024 | 57075263600; 57192514164; 57210472032; 56430165800 | crysta12@kigam.re.kr;crystal2@kigam.re.kr; | WASTE MANAGEMENT | WASTE MANAGE | 0956-053X | 1879-2456 | 116 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES | 2020 | 7.145 | 10.4 | 0.13 | 2025-06-25 | 10 | 11 | Integrated gasification combined cycle slag; Automated SEM-EDS systems; Amorphous phase; Si-Al-Ca phases; Alkali-activated materials | BLAST-FURNACE SLAG; FLY-ASH; PORTLAND-CEMENT; STEEL SLAG; COAL; GASIFICATION; EXPANSION; CERAMICS; GLASS; LIME | Alkali-activated materials; Amorphous phase; Automated SEM-EDS systems; Integrated gasification combined cycle slag; Si-Al-Ca phases | Coal Ash; Microscopy, Electron, Scanning; Recycling; Amorphous silicon; Automation; C (programming language); Calcium oxide; Electric discharges; Electric power generation; Fly ash; Lime; Recycling; Scanning electron microscopy; Silicon; Slags; aluminum; calcium; silicon; Aluminosilicate materials; Average bulk compositions; Chemical compositions; Dissolution mechanism; Electricity generation; Energy dispersive spectrometry; Integrated gasification combined cycle; Volumetric expansion; chemical composition; concentration (composition); dissolution; electricity generation; hydration; recycling; scanning electron microscopy; slag; Article; automation; chemical composition; concentration (parameter); controlled study; dissolution; energy dispersive X ray spectroscopy; hydration; integrated gasification combined cycle slag; limit of detection; particle size; priority journal; process optimization; recycling; scanning electron microscopy; slag; waste management; fly ash; recycling; scanning electron microscopy; Combined cycle power plants | English | 2020 | 2020-10-01 | 10.1016/j.wasman.2020.08.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Behavioral evidence for geomagnetic imprinting and transgenerational inheritance in fruit flies | Certain long-distance migratory animals, such as salmon and sea turtles, are thought to imprint on the magnetic field of their natal area and to use this information to help them return as adults. Despite a growing body of indirect support for such imprinting, direct experimental evidence thereof remains elusive. Here, using the fruit fly as a magnetoreceptive model organism, we demonstrate that exposure to a specific geographic magnetic field during a critical period of early development affected responses to a matching magnetic field gradient later in life. Specifically, hungry flies that had imprinted on a specific magnetic field from 1 of 3 widely separated geographic locations responded to the imprinted field, but not other magnetic fields, by moving downward, a geotactic behavior associated with foraging. This same behavior occurred spontaneously in the progeny of the next generation: female progeny moved downward in response to the field on which their parents had imprinted, whereas male progeny did so only in the presence of these females. These results represent experimental evidence that organisms can learn and remember a magnetic field to which they were exposed during a critical period of development. Although the function of the behavior is not known, one possibility is that imprinting on the magnetic field of a natal area assists flies and their offspring in recognizing locations likely to be favorable for foraging and reproduction. | Oh, In-Taek; Kwon, Hye-Jin; Kim, Soo-Chan; Kim, Hyung-Jun; Lohmann, Kenneth J.; Chae, Kwon-Seok | Kyungpook Natl Univ, Dept Biol Educ, 41566, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Nanosci & Nanotechnol, Daegu 41566, South Korea; Hankyong Natl Univ, CDepartment Elect & Elect Engn, Anseong 17579, South Korea; KBRI, Dementia Res Grp, Daegu 41062, South Korea; Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41566, South Korea | 57195491418; 57213653536; 55974550600; 57191717907; 7005857056; 15743626400 | kschae@knu.ac.kr; | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | P NATL ACAD SCI USA | 0027-8424 | 117 | 2 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 11.205 | 10.4 | 0.59 | 2025-06-25 | 14 | 15 | magnetic imprinting; geomagnetic field; fruit fly; transgenerational inheritance; magnetoreception | LONG-DISTANCE MIGRATION; MAGNETIC ORIENTATION; DROSOPHILA; COMPASS; NEUROBIOLOGY; NAVIGATION; LIGHT; MAPS | Fruit fly; Geomagnetic field; Magnetic imprinting; Magnetoreception; Transgenerational inheritance | Animal Migration; Animals; Drosophila; Female; Homing Behavior; Imprinting, Psychological; Magnetic Fields; Male; Reproduction; adult; animal experiment; article; Drosophila; female; foraging; geography; imprinting (psychology); inheritance; magnetic field; male; nonhuman; progeny; animal; Drosophila; homing behavior; magnetic field; physiology; population migration; reproduction | English | 2020 | 2020-01-14 | 10.1073/pnas.1914106117 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Distinct roles of stereociliary links in the nonlinear sound processing and noise resistance of cochlear outer hair cells | Outer hair cells (OHCs) play an essential role in hearing by acting as a nonlinear amplifier which helps the cochlea detect sounds with high sensitivity and accuracy. This nonlinear sound processing generates distortion products, which can be measured as distortion-product otoacoustic emissions (DPOAEs). The OHC stereocilia that respond to sound vibrations are connected by three kinds of extracellular links: tip links that connect the taller stereocilia to shorter ones and convey force to the mechanoelectrical transduction channels, tectorial membrane-attachment crowns (TM-ACs) that connect the tallest stereocilia to one another and to the overlying TM, and horizontal top connectors (HTCs) that link adjacent stereocilia. While the tip links have been extensively studied, the roles that the other two types of links play in hearing are much less clear, largely because of a lack of suitable animal models. Here, while analyzing genetic combinations of tubby mice, we encountered models missing both HTCs and TM-ACs or HTCs alone. We found that the tubby mutation causes loss of both HTCs and TM-ACs due to a mislocalization of stereocilin, which results in OHC dysfunction leading to severe hearing loss. Intriguingly, the addition of the modifier allele modifier of tubby hearing 1 in tubby mice selectively rescues the TM-ACs but not the HTCs. Hearing is significantly rescued in these mice with robust DPOAE production, indicating an essential role of the TM-ACs but not the HTCs in normal OHC function. In contrast, the HTCs are required for the resistance of hearing to damage caused by noise stress. | Han, Woongsu; Shin, Jeong-Oh; Ma, Ji-Hyun; Min, Hyehyun; Jung, Jinsei; Lee, Jinu; Kim, Un-Kyung; Choi, Jae Young; Moon, Seok Jun; Moon, Dae Won; Bok, Jinwoong; Kim, Chul Hoon | Yonsei Univ, Coll Med, Dept Pharmacol, Seoul 03722, South Korea; Yonsei Univ, Coll Med, Brain Korea 21 Project Med Sci, Seoul 03722, South Korea; Yonsei Univ, Coll Med, Dept Anat, Seoul 03722, South Korea; Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Seoul 03722, South Korea; Yonsei Univ, Coll Med, Dept Otorhinolaryngol, Seoul 03722, South Korea; Yonsei Univ, Yonsei Inst Pharmaceut Sci, Coll Pharm, Incheon 21983, South Korea; Kyungpook Natl Univ, Dept Biol, Daegu 41566, South Korea; Yonsei Univ, Coll Dent, Dept Oral Biol, Seoul 03722, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Dept New Biol, Daegu 42988, South Korea | ; Bok, Jinwoong/B-8982-2016; Kim, You Sun/B-2881-2015; Choi, Hayoung/AAI-8638-2020; Jinsei, Jung/ADX-6032-2022; Kim, Ji/AAN-5655-2021 | 55865839500; 37361704500; 56566914700; 35201765400; 55546452200; 12783869000; 7102248968; 56145609500; 55463996200; 16433239500; 25222398800; 36065422100 | dwmoon@dgist.ac.kr;bokj@yuhs.ac;kimhoon@yuhs.ac; | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | P NATL ACAD SCI USA | 0027-8424 | 117 | 20 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 11.205 | 10.4 | 0.45 | 2025-06-25 | 19 | 15 | hearing loss; outer hair cell; stereocilia; tubby; stereocilin | TECTORIAL MEMBRANE; TUBBY PROTEINS; BUNDLE; GENE; TRAFFICKING; MUTATIONS; HOMOLOGY; MODELS; MICE; FAT | Hearing loss; Outer hair cell; Stereocilia; Stereocilin; Tubby | Acoustic Stimulation; Animals; Hair Cells, Auditory, Outer; Hearing Loss; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Models, Animal; Noise; Otoacoustic Emissions, Spontaneous; Sound; Stereocilia; Tectorial Membrane; membrane protein; stereocilin; unclassified drug; MAP1A protein, mouse; microtubule associated protein; signal peptide; Strc protein, mouse; acoustic stress; animal experiment; animal model; Article; auditory stimulation; auditory system function; controlled study; distortion product otoacoustic emission; gene; gene mutation; hearing acuity; hearing impairment; modifier gene; mouse; noise resistance; nonhuman; nonlinear sound processing; outer hair cell; pathogenesis; priority journal; protein localization; stereocilium; stimulus response; tubby gene; animal; C57BL mouse; cytology; genetics; hearing impairment; knockout mouse; noise; outer hair cell; physiology; sound; spontaneous otoacoustic emission; stereocilium; tectorial membrane | English | 2020 | 2020-05-19 | 10.1073/pnas.1920229117 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluating the employment impact of recycling performance in Florida | Recycling solid waste not only produces environmental and health benefits, but also generates economic benefit. This paper empirically evaluates the employment impact of Florida county recycling programs from 2000 through 2011, applying a fixed effects regression model. The results indicate that a one percentage point increase of county recycling rate leads to a 0.4% job growth in overall solid waste and recycling industry. However, the impact of recycling programs on green jobs are not uniform across the recycling subsectors: the effect is concentrated in the recycling processing sector while the solid waste collection sector and scrap materials businesses are unlikely to be influenced by county's recycling performance. (C) 2019 Elsevier Ltd. All rights reserved. | Liu, Yuan; Park, Sunjoo; Yi, Hongtao; Feiock, Richard | George Washington Univ, Trachtenberg Sch Publ Policy & Publ Adm, 805 21st St NW, Washington, DC 20052 USA; Kyungpook Natl Univ, Sch Publ Adm, 80 Daehak Ro, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Publ Affairs, 80 Daehak Ro, Daegu, South Korea; Ohio State Univ, John Glenn Coll Publ Affairs, 1810 Coll Rd, Columbus, OH 43210 USA; Florida State Univ, Askew Sch Publ Adm & Policy, 600 W Coll Ave, Tallahassee, FL 32306 USA | ; Yi, Hongtao/AAU-4740-2021 | 56613128700; 56965789700; 55598007400; 6602814751 | liuyuan1129@gwu.edu;sunjpark@knu.ac.kr;yi.201@osu.edu;rfeiock@fsu.edu; | WASTE MANAGEMENT | WASTE MANAGE | 0956-053X | 1879-2456 | 101 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES | 2020 | 7.145 | 10.4 | 0.66 | 2025-06-25 | 24 | 27 | Solid waste management; Recycling; Green job; Green economic development; Circular economy | SOLID-WASTE; GREEN JOBS; ECONOMY; INNOVATION; PROGRAMS; POLITICS; BUSINESS; GROWTH | Circular economy; Green economic development; Green job; Recycling; Solid waste management | Employment; Florida; Recycling; Solid Waste; Waste Management; Florida [United States]; United States; Economics; Recycling; Regression analysis; Scrap metal reprocessing; Solid wastes; Waste management; Circular economy; Economic benefits; Economic development; Fixed effects regression models; Green job; Recycling programs; Solid waste and recycling industry; Solid waste collection; cost-benefit analysis; economic development; environmental economics; green economy; performance assessment; recycling; solid waste; waste management; article; economic development; employment; Florida; recycling; solid waste management; employment; Florida; recycling; solid waste; waste management; Economic and social effects | English | 2020 | 2020-01 | 10.1016/j.wasman.2019.10.025 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN/GDF11 inhibitor, increases muscle mass but weakens bone | Growth and differentiation factor 11 (GDF11) and myostatin ( MSTN) are closely related transforming growth factor beta (TGF-beta) family members, but their biological functions are quite distinct. While MSTN has been widely shown to inhibit muscle growth, GDF11 regulates skeletal patterning and organ development during embryogenesis. Postnatal functions of GDF11, however, remain less clear and controversial. Due to the perinatal lethality of Gdf11 null mice, previous studies used recombinant GDF11 protein to prove its postnatal function. However, recombinant GDF11 and MSTN proteins share nearly identical biochemical properties, and most GDF11-binding molecules have also been shown to bind MSTN, generating the possibility that the effects mediated by recombinant GDF11 protein actually reproduce the endogenous functions of MSTN. To clarify the endogenous functions of GDF11, here, we focus on genetic studies and show that Gdf11 null mice, despite significantly down-regulating Mstn expression, exhibit reduced bone mass through impaired osteoblast (OB) and chondrocyte ( CH) maturations and increased osteoclastogenesis, while the opposite is observed in Mstn null mice that display enhanced bone mass. Mechanistically, Mstn deletion up-regulates Gdf11 expression, which activates bone morphogenetic protein (BMP) signaling pathway to enhance osteogenesis. Also, mice overexpressing follistatin (FST), a MSTN/GDF11 inhibitor, exhibit increased muscle mass accompanied by bone fractures, unlike Mstn null mice that display increased muscle mass without fractures, indicating that inhibition of GDF11 impairs bone strength. Together, our findings suggest that GDF11 promotes osteogenesis in contrast to MSTN, and these opposing roles of GDF11 and MSTN must be considered to avoid the detrimental effect of GDF11 inhibition when developing MSTN/GDF11 inhibitors for therapeutic purposes. | Suh, Joonho; Kim, Na-Kyung; Lee, Seung-Hoon; Eom, Je-Hyun; Lee, Youngkyun; Park, Joo-Cheol; Woo, Kyung Mi; Baek, Jeong-Hwa; Kim, Jung-Eun; Ryoo, Hyun-Mo; Lee, Se-Jin; Lee, Yun-Sil | Seoul Natl Univ, Sch Dent, Dept Mol Genet, Seoul 08826, South Korea; Seoul Natl Univ, Dent Res Inst, Seoul 08826, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Biochem, Daegu 41566, South Korea; Seoul Natl Univ, Sch Dent, Dept Oral Histol Dev Biol, Seoul 08826, South Korea; Jackson Lab Genom Med, Farmington, CT 06032 USA; Univ Connecticut, Sch Med, Dept Genet & Genome Sci, Farmington, CT 06030 USA | ; Woo, Kyung/A-2793-2009; Woo, Kyung Mi/A-2793-2009; Park, Joo Cheol/AGU-5020-2022; Baek, Jeong-Hwa/A-8628-2012; Ryoo, Hyun-Mo/D-5839-2012 | 57210638674; 57210646929; 59056027600; 57210635516; 36062942200; 57209640630; 34870805900; 14064416200; 57209054588; 7005485966; 7601392688; 57226670628 | yunlee@snu.ac.kr; | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | P NATL ACAD SCI USA | 0027-8424 | 117 | 9 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 11.205 | 10.4 | 1.67 | 2025-06-25 | 53 | 49 | GDF11; myostatin; follistatin; osteogenesis; BMP | DIFFERENTIATION FACTOR 11; DEVELOPING MOUSE LIMB; BETA SUPERFAMILY; MYOSTATIN ACTIVITY; GENE-THERAPY; ACTIVIN; GROWTH; AGE; EXPRESSION; MUTATION | BMP; Follistatin; GDF11; Myostatin; Osteogenesis | Animals; Bone and Bones; Bone Morphogenetic Proteins; Chondrocytes; Down-Regulation; Follistatin; Gene Expression Regulation, Developmental; Growth Differentiation Factors; Mice; Mice, Knockout; Muscle Development; Muscles; Myostatin; Osteoblasts; Osteogenesis; Signal Transduction; Transforming Growth Factor beta; bone morphogenetic protein; follistatin; growth differentiation factor; growth differentiation factor 11; myostatin; unclassified drug; bone morphogenetic protein; follistatin; Gdf11 protein, mouse; growth differentiation factor; Mstn protein, mouse; myostatin; transforming growth factor beta; adult; animal cell; animal experiment; animal tissue; Article; bone development; bone disease; bone strength; bone weakness; cell maturation; chondrocyte; controlled study; down regulation; embryo; fracture; gene deletion; gene expression; gene overexpression; mouse; Mstn gene; muscle mass; newborn; nonhuman; osteoblast; osteoclastogenesis; priority journal; protein function; signal transduction; upregulation; young adult; animal; bone; bone development; gene expression regulation; genetics; knockout mouse; metabolism; muscle; muscle development; pathology; physiology | English | 2020 | 2020-03-03 | 10.1073/pnas.1916034117 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Split-TurboID enables contact-dependent proximity labeling in cells | Proximity labeling catalyzed by promiscuous enzymes, such as TurboID, have enabled the proteomic analysis of subcellular regions difficult or impossible to access by conventional fractionation-based approaches. Yet some cellular regions, such as organelle contact sites, remain out of reach for current PL methods. To address this limitation, we split the enzyme TurboID into two inactive fragments that recombine when driven together by a protein-protein interaction or membrane-membrane apposition. At endoplasmic reticulum-mitochondria contact sites, reconstituted TurboID catalyzed spatially restricted biotinylation, enabling the enrichment and identification of >100 endogenous proteins, including many not previously linked to endoplasmic reticulum-mitochondria contacts. We validated eight candidates by biochemical fractionation and overexpression imaging. Overall, split-TurboID is a versatile tool for conditional and spatially specific proximity labeling in cells. | Cho, Kelvin F.; Branon, Tess C.; Rajeev, Sanjana; Svinkina, Tanya; Udeshi, Namrata D.; Thoudam, Themis; Kwak, Chulhwan; Rhee, Hyun-Woo; Lee, In-Kyu; Carr, Steven A.; Ting, Alice Y. | Stanford Univ, Canc Biol Program, Stanford, CA 94305 USA; Stanford Univ, Dept Genet, Stanford, CA 94305 USA; Stanford Univ, Dept Biol, Stanford, CA 94305 USA; Stanford Univ, Dept Chem, Stanford, CA 94305 USA; MIT, Dept Chem, Cambridge, MA 02139 USA; Broad Inst MIT & Harvard, Cambridge, MA 02142 USA; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu 37224, South Korea; Seoul Natl Univ, Dept Chem, Seoul 08826, South Korea; Ulsan Natl Inst Sci & Technol, Dept Chem, Ulsan 44919, South Korea; Seoul Natl Univ, Sch Biol Sci, Seoul 08826, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu 41944, South Korea; Chan Zuckerberg Biohub, San Francisco, CA 94158 USA | Carr, Steven/C-4924-2013; Udeshi, Namrata/HCH-2222-2022; thoudam, themis/ACM-3919-2022; Rhee, Hyun-Woo/AAS-3508-2021; Branon, Tess/HSB-8317-2023; Rajeev, Sanjana/NJS-1016-2025 | 57208241167; 57194769122; 57217038606; 55614527300; 23029149600; 57192905626; 35940010600; 35734943800; 36071537600; 7202363695; 7102858567 | ayting@stanford.edu; | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | P NATL ACAD SCI USA | 0027-8424 | 1091-6490 | 117 | 22 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 11.205 | 10.4 | 5.75 | 2025-06-25 | 230 | 203 | proximity labeling; ER-mitochondria contacts; split-TurboID | ENDOPLASMIC-RETICULUM; PROTEOMIC ANALYSIS; PROTEIN INTERACTIONS; BIOTIN REPRESSOR; LIVING CELLS; ER MEMBRANES; MITOCHONDRIAL; PEROXIDASE; FORM; BIOTINYLATION | ER-mitochondria contacts; Proximity labeling; Split-TurboID | Biotinylation; Endoplasmic Reticulum; HEK293 Cells; Humans; Membrane Proteins; Mitochondria; Mitochondrial Membranes; Proteome; Staining and Labeling; membrane protein; proteome; analytic method; Article; binding affinity; biochemistry; biotinylation; cell organelle; controlled study; endoplasmic reticulum; enzyme reconstitution; enzyme specificity; human; human cell; lipogenesis; mitochondrial membrane; mitochondrion; priority journal; protein analysis; protein domain; protein protein interaction; proteomics; proximity labeling; split TurboID method; synapse; HEK293 cell line; metabolism; staining | English | 2020 | 2020-06-02 | 10.1073/pnas.1919528117 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The 2019 Revised Version of Association Research Circulation Osseous Staging System of Osteonecrosis of the Femoral Head | Background: The Association Research Circulation Osseous (ARCO) presents the 2019 revised staging system of osteonecrosis of the femoral head (ONFH) based on the 1994 ARCO classification. Methods: In October 2018, ARCO established a task force to revise the staging system of ONFH. The task force involved 29 experts who used a web-based survey for international collaboration. Content validity ratios for each answer were calculated to identify the levels of agreement. For the rating queries, a consensus was defined when more than 70% of the panel members scored a 4 or 5 rating on a 5-point scale. Results: Response rates were 93.1%-100%, and through the 4-round Delphi study, the 1994 ARCO classification for ONFH was successfully revised. The final consensus resulted in the following 4-staged system: stage I-X-ray is normal, but either magnetic resonance imaging or bone scan is positive; stage II-X-ray is abnormal (subtle signs of osteosclerosis, focal osteoporosis, or cystic change in the femoral head) but without any evidence of subchondral fracture, fracture in the necrotic portion, or flattening of the femoral head; stage III-fracture in the subchondral or necrotic zone as seen on X-ray or computed tomography scans. This stage is further divided into stage IIIA (early, femoral head depression 2 mm); and stage IV-X-ray evidence of osteoarthritis with accompanying joint space narrowing, acetabular changes, and/or joint destruction. This revised staging system does not incorporate the previous subclassification or quantitation parameters, but the panels agreed on the future development of a separate grading system for predicting disease progression. Conclusion: A staging system has been developed to revise the 1994 ARCO classification for ONFH by an expert panel-based Delphi survey. ARCO approved and recommends this revised system as a universal staging of ONFH. (C) 2019 Published by Elsevier Inc. | Yoon, Byung-Ho; Mont, Michael A.; Koo, Kyung-Hoi; Chen, Chung-Hwan; Cheng, Edward Y.; Cui, Quanjun; Drescher, Wolf; Gangji, Valerie; Goodman, Stuart B.; Ha, Yong-Chan; Hernigou, Philippe; Hungerford, Marc W.; Iorio, Richard; Jo, Woo-Lam; Jones, Lynne C.; Khanduja, Vikas; Kim, Harry K. W.; Kim, Shin-Yoon; Kim, Tae-Young; Lee, Hee Young; Lee, Mel S.; Lee, Young-Kyun; Lee, Yun Jong; Nakamura, Junichi; Parvizi, Javad; Sakai, Takashi; Sugano, Nobuhiko; Takao, Masaki; Yamamoto, Takuaki; Zhao, De-Wei | Inje Univ, Seoul Paik Hosp, Coll Med, Dept Orthopaed Surg, Seoul, South Korea; Lenox Hill Hosp, Northwell Hlth, Dept Orthopaed Surg, New York, NY 10021 USA; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Orthopaed Surg, 166 Gumi Ro,KS009, Seongnam 463707, South Korea; Kaoshiung Med Univ Hosp, Dept Orthopaed Surg, Kaohsiung, Taiwan; Univ Minnesota, Dept Orthopaed Surg, Sch Med, Minneapolis, MN 55455 USA; Univ Virginia, Sch Med, Dept Orthopaed Surg, Charlottesville, VA 22908 USA; Rhein Westfal TH Aachen, Dept Orthoped & Trauma Surg, Aachen, Germany; Univ Libre Bruxelles, Hop Erasme, Dept Rheumatol & Phys Med, Brussels, Belgium; Stanford Univ, Dept Orthopaed Surg, Sch Med, Redwood City, CA USA; Chung Ang Univ, Dept Orthopaed Surg, Coll Med, Seoul, South Korea; Hop Henri Mondor, Creteil, France; Mercy Med Ctr, Dept Orthoped Surg, Baltimore, MD USA; Brigham & Womens Hosp, Dept Orthopaed Surg, 75 Francis St, Boston, MA 02115 USA; Catholic Univ Korea, Seoul St Marys Hosp, Dept Orthopaed Surg, Coll Med, Seoul, South Korea; Johns Hopkins Univ, Sch Med, Ctr Metab & Obes Res, Dept Orthopaed Surg, Baltimore, MD USA; Cambridge Univ Hosp, Dept Trauma & Orthopaed, Cambridge, England; UT Southwestern Med Ctr, Scottish Rite Hosp Children, Ctr Excellence Hip Disorders, Dallas, TX USA; Kyungpook Natl Univ, Grad Sch Med, Dept Orthoped Surg, Daegu, South Korea; KonKuk Univ, Dept Orthoped Surg, Med Ctr, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Ctr Prevent Med & Publ Hlth, Seongnam, South Korea; Kaohsiung Chang Gung Mem Hosp, Dept Orthopaed Surg, Kaohsiung, Taiwan; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Seoul Natl Univ, Coll Med, Seongnam, South Korea; Chiba Univ, Grad Sch Med, Dept Orthopaed Surg, Chiba, Japan; Rothman Orthopaed Inst, Dept Orthoped Surg, Philadelphia, PA USA; Osaka Univ, Grad Sch Med, Dept Orthopaed Surg, Suita, Osaka, Japan; Osaka Univ, Grad Sch Med, Dept Orthopaed Med Engn, Suita, Osaka, Japan; Fukuoka Univ, Fac Med, Dept Orthopaed Surg, Jonan Ku, Fukuoka, Japan; Dalian Univ, Affiliated Zhongshan Hosp, Dept Orthoped, Dalian, Peoples R China | ; Kim, Soo/J-5411-2012; Kim, Harry/AAE-1892-2020; Chen, Chung-Hwan/D-4036-2009; Sugano, Nobuhiko/AAA-3359-2020; Goodman, Stuart/AAZ-7499-2020; Zhao, Dewei/G-8369-2016; Koo, Kyung-Hoi/D-7053-2012; Kim, Tae/C-1272-2009; Lee, Young-Kyun/D-6175-2012; Yamamoto, Takuaki/AAR-6242-2020; lee, hy/GRS-0797-2022; Khanduja, Vikas/U-9318-2017 | 15078729100; 7005154075; 23488849400; 57203937692; 7201743350; 7103080108; 7004289286; 6602320265; 7402115472; 7102444576; 7005153893; 6603546349; 7006242982; 57040633000; 25625068200; 11339699000; 27171955900; 26663842900; 57049785800; 7501482409; 34971445900; 15044971000; 56584775600; 35473800400; 57210238808; 55176978800; 7101688414; 58617101500; 8069263600; 13104086400 | JOURNAL OF ARTHROPLASTY | J ARTHROPLASTY | 0883-5403 | 1532-8406 | 35 | 4 | SCIE | ORTHOPEDICS | 2020 | 4.757 | 10.4 | 16.27 | 2025-06-25 | 219 | 227 | staging; hip; osteonecrosis; avascular necrosis; Delphi | TOTAL HIP-ARTHROPLASTY; NONTRAUMATIC OSTEONECROSIS; ROTATIONAL OSTEOTOMY; AVASCULAR NECROSIS; ASYMPTOMATIC OSTEONECROSIS; CLASSIFICATION-SYSTEM; NATURAL-HISTORY; REPRODUCIBILITY; INTEROBSERVER; COLLAPSE | avascular necrosis; Delphi; hip; osteonecrosis; staging | Femur Head; Femur Head Necrosis; Humans; Magnetic Resonance Imaging; Radiography; Tomography, X-Ray Computed; Article; Association Research Circulation Osseous 2019 revised version; bone scintiscanning; computer assisted tomography; content validity; disease classification; femur head necrosis; nuclear magnetic resonance imaging; osteoporosis; osteosclerosis; radiography; diagnostic imaging; femoral head; femur head necrosis; human; x-ray computed tomography | English | 2020 | 2020-04 | 10.1016/j.arth.2019.11.029 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Binary B2O3-Bi2O3 glasses: scrutinization of directly and indirectly ionizing radiations shielding abilities | For five B2O3-Bi2O3 glasses, detailedly, gamma, neutron, & proton, alpha, and electron (charged particles) shielding efficacies were assessed in this work. The crucial photon attenuating (interaction probabilities) parameter i.e., mass attenuation coefficient (mu/rho) was calculated by Phy-X/PSD software and procured mu/rho results have been verified through MCNPX, Geant4, & FLUKA codes mu/rho findings from which a quality unanimity among them was noticed over an energy range of 15 KeV-15 MeV. Following mu/rho & linear attenuation coefficient (mu) outcomes, Z(eff), N-eff, HVL, TVL, and MFP have been reckoned and found that all mu/rho, Zeff, Neff, HVL, TVL, & MFP highly rest on glass chemical contents & photon energy. Z(eq) and by applying geometric progression (G-P) fitting parameters (a, b, c, d, & X-k coefficients) EBFs & EABFs were appraised at ten specific penetration depths up to 40 mfp, at energy range of 0.015-15 MeV. The inferred RPE quantities confirmed all chosen glasses quintessential absorption competence for lower energy gamma-rays. Utilizing SRIM code the mass stopping powers (MSPs) & projected ranges (PRs) for protons ((Psi(P))&(Phi(P))) and alpha particles (Psi(A))&(Psi(A)), and with the help of ESTAR database, electron MSP (Psi(E)) & continuous slowing down approximation (CSDA) ranges for electrons have been approximated at 0.015 -15 MeV KE. The fast neutron removal cross-sections (Sigma(R)) were estimated and obtained Sigma(R) was diversified at 0.10978-0.12144 cm(-1) range relying on Bi2O3 inclusion in glasses. Based on all acquired outputs, 57.5B(2)O(3)-42.5Bi(2)O(3) (mol%) glass possesses superior attenuation capacity for gamma-rays and fast neutrons as well as charged particles. (C) 2020 The Author(s). Published by Elsevier B.V. | Lakshminarayana, G.; Kumar, Ashok; Tekin, H. O.; Issa, Shams A. M.; Al-Buriahi, M. S.; Lee, Dong-Eun; Yoon, Jonghun; Park, Taejoon | Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea; Univ Coll, Dept Phys, Dhuri, Punjab, India; Univ Sharjah, Coll Hlth Sci, Med Diagnost Imaging Dept, Sharjah 27272, U Arab Emirates; Univ Tabuk, Fac Sci, Dept Phys, Tabuk, Saudi Arabia; Al Azhar Univ, Fac Sci, Phys Dept, Assiut 71452, Egypt; Sakarya Univ, Dept Phys, Sakarya, Turkey; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy, 1370 Sangyeok Dong, Daegu 702701, South Korea; Hanyang Univ, Dept Mech Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea; Hanyang Univ, Dept Robot Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea | ; Kumar, Ashok/A-7742-2012; Tekin, Huseyin Ozan/J-9611-2016; Tekin, Huseyin/J-9611-2016; Issa, Shams/M-6825-2017; Al-Buriahi, M.S./HKW-2385-2023 | 57194637883; 57307625500; 56971130700; 55336154700; 57191693608; 56605563300; 56449838900; 55717001200 | gandham@knu.ac.kr;dolee@knu.ac.kr;yooncsmd@gmail.com;taejoon@hanyang.ac.kr; | JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T | J MATER RES TECHNOL | 2238-7854 | 2214-0697 | 9 | 6 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2020 | 5.039 | 10.6 | 3.25 | 2025-06-25 | 86 | 86 | B2O3-Bi2O3 glass; Geant4 code; Phy-X/PSD program; Charged particles projected range; Fast neutron removal cross-sections; Mass attenuation coefficient | GAMMA-RAY; STOPPING POWER; FEATURES; GEANT4 | B<sub>2</sub>O<sub>3</sub>–Bi<sub>2</sub>O<sub>3</sub> glass; Charged particles projected range; Fast neutron removal cross-sections; Geant4 code; Mass attenuation coefficient; Phy-X/PSD program | Bismuth compounds; Charged particles; Gamma rays; Glass; Photons; Radiation shielding; B2O3–bi2O3 glass; Charged particle projected range; Energy ranges; Fast neutron removal cross-section; Fast neutrons; GEANT4 code; Mass attenuation coefficients; Neutron removal; Phy-X/PSD program; Projected range; Neutrons | English | 2020 | 2020 (NOV-DEC) | 10.1016/j.jmrt.2020.10.019 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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